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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">News</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2023-11-14T16:22:48.496">November 14, 2023</time></div><h1 class="text-[26px] font-medium leading-8">What We’re Reading: Medicaid Coverage Errors; Gender Disparities in Health Research; Improved Lung Cancer Survival Rates</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/ajmc-staff">AJMC Staff</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title="What We’re Reading: Medicaid Coverage Errors; Gender Disparities in Health Research; Improved Lung Cancer Survival Rates" aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 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class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#cb2128"></circle><path d="M32,16c-8.8,0-16,7.2-16,16c0,6.6,3.9,12.2,9.6,14.7c0-1.1,0-2.5,0.3-3.7 c0.3-1.3,2.1-8.7,2.1-8.7s-0.5-1-0.5-2.5c0-2.4,1.4-4.1,3.1-4.1c1.5,0,2.2,1.1,2.2,2.4c0,1.5-0.9,3.7-1.4,5.7 c-0.4,1.7,0.9,3.1,2.5,3.1c3,0,5.1-3.9,5.1-8.5c0-3.5-2.4-6.1-6.7-6.1c-4.9,0-7.9,3.6-7.9,7.7c0,1.4,0.4,2.4,1.1,3.1 c0.3,0.3,0.3,0.5,0.2,0.9c-0.1,0.3-0.3,1-0.3,1.3c-0.1,0.4-0.4,0.6-0.8,0.4c-2.2-0.9-3.3-3.4-3.3-6.1c0-4.5,3.8-10,11.4-10 c6.1,0,10.1,4.4,10.1,9.2c0,6.3-3.5,11-8.6,11c-1.7,0-3.4-0.9-3.9-2c0,0-0.9,3.7-1.1,4.4c-0.3,1.2-1,2.5-1.6,3.4 c1.4,0.4,3,0.7,4.5,0.7c8.8,0,16-7.2,16-16C48,23.2,40.8,16,32,16z" fill="white"></path></svg></button><button aria-label="email" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#7f7f7f"></circle><path d="M17,22v20h30V22H17z M41.1,25L32,32.1L22.9,25H41.1z M20,39V26.6l12,9.3l12-9.3V39H20z" fill="white"></path></svg></button><a class="print-wrap flex justify-center items-center cursor-pointer"><svg id="print" xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="currentColor" class="print bi bi-printer" viewBox="0 0 16 16"> <path d="M2.5 8a.5.5 0 1 0 0-1 .5.5 0 0 0 0 1z"></path> <path d="M5 1a2 2 0 0 0-2 2v2H2a2 2 0 0 0-2 2v3a2 2 0 0 0 2 2h1v1a2 2 0 0 0 2 2h6a2 2 0 0 0 2-2v-1h1a2 2 0 0 0 2-2V7a2 2 0 0 0-2-2h-1V3a2 2 0 0 0-2-2H5zM4 3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1v2H4V3zm1 5a2 2 0 0 0-2 2v1H2a1 1 0 0 1-1-1V7a1 1 0 0 1 1-1h12a1 1 0 0 1 1 1v3a1 1 0 0 1-1 1h-1v-1a2 2 0 0 0-2-2H5zm7 2v3a1 1 0 0 1-1 1H5a1 1 0 0 1-1-1v-3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1z"></path></svg></a></div><style> .print-wrap { width: 32px; height: 32px; background: #7F7F7F; border-radius: 100%; } .print { background: #7F7F7F; color: white; padding: 2px; border-radius: 100%; } </style></div></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><p class="py-2 mb-2 text-sm italic text-gray-600">Up to 30 million individuals could lose Medicaid coverage; a new initiative demands increased focus on women's health issues; survey reports increased 5-year lung cancer survival rates from 2015 to 2019.</p><div class="py-2"><div class="blockText_blockContent__TbCXh"><h3 class="text-xl pb-4 pt-2"><strong>Millions of America's Poorest at Risk of Losing Medicaid Coverage</strong></h3><p class="pb-2">A report from Avalere reveals that up to 30 million of the most vulnerable Americans may lose Medicaid coverage due to flawed state reviews, with issues ranging from prolonged wait times in Florida to confusing paperwork in Arkansas, <a rel="nofollow noreferrer noopener" target="_blank" href="https://apnews.com/article/medicaid-eligibility-texas-florida-disenrollments-fe7c10276e86ab909060dd6fbea60328">according to The Associated Press</a>. Despite warnings from poverty experts, the Biden administration is accused of not effectively intervening. Advocates fear systemic problems are being ignored, pointing to procedural disenrollments, erroneous removals, and a lack of transparency in the reevaluation process.</p><p class="pb-2"></p><h3 class="text-xl pb-4 pt-2"><strong>Administration Seeks to Address Gender Disparities in Health Research</strong></h3><p class="pb-2">The Biden administration, led by First Lady Jill Biden, is launching a new initiative to address the longstanding neglect of women's health in research, giving officials 45 days to propose specific actions for improvement, <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.usatoday.com/story/news/politics/2023/11/13/jill-biden-research-womens-health-issues-menopause/71569223007/">according to USA Today</a>. Carolyn M. Mazure, PhD, a renowned expert in women's health from Yale University, will lead the initiative, focusing on critical areas such as heart attacks and menopause. Despite progress since the establishment of the National Institutes of Health's Office of Research on Women’s Health in 1990, significant gaps persist, with conditions like Alzheimer disease and heart disease disproportionately affecting women but receiving inadequate research funding.</p><p class="pb-2"></p><h3 class="text-xl pb-4 pt-2"><strong>Encouraging Trends in Lung Cancer Survival Rates for Marginalized Communities</strong></h3><p class="pb-2">A recent survey by the American Lung Association indicates a positive shift in lung cancer survival rates, particularly among historically marginalized communities, despite ongoing racial disparities in health care, <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.npr.org/sections/health-shots/2023/11/14/1212801700/lung-cancer-survival-rates-rise-but-low-screening-rates-leave-many-people-at-ris">according to NPR</a>. The 5-year survival rate for lung cancer increased by 22% from 2015 to 2019, reaching 26.6% across all racial and ethnic groups. Notably, people of color experienced a 17% improvement in survival rates between 2017 and 2019, now standing at 23.7%. Despite the progress, disparities persist, with varying survival rates among different racial groups, highlighting the need for continued efforts to address health care inequities.</p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/navigating-healthcare-access-and-decision-making"><div class="w-full shadow-md shadow-gray-800 overflow-hidden 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src="https://cdn.sanity.io/images/0vv8moc6/ajmc/75f5ad09048956408787303005237932f9707c3c-5433x2890.jpg?fit=crop&auto=format" alt="MDS wooden blocks held by hand in glove | Image Credit: © Sviatlana - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/venetoclax-may-be-an-option-for-children-with-r-r-aml-mds?utm_source=www.ajmc.com&utm_medium=relatedContent">Venetoclax May Be an Option for Children With R/R AML, MDS </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/venetoclax-may-be-an-option-for-children-with-r-r-aml-mds?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The single-center report showed the therapy had a favorable safety profile and manageable side effects in children with relapsed or refractory (R/R) acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent">Breaking the Cycle: The Importance of Early Intervention in Hidradenitis Suppurativa</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Prompt care supports mental well-being, as hidradenitis suppurativa is often associated with depression and anxiety due to its physical and social challenges.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6bd0e6a5c734135abb6fa97501b6375dc31df9c2-5600x3733.jpg?fit=crop&auto=format" alt="Medicare enrollment model | image credit: Vitalii Vodolazskyi - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent">New Proposal Aims to Expand Medicaid and Medicare Coverage for Obesity Drugs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">If made official, the proposed rule would give Part D and Medicaid beneficiaries expanded coverage to antiobesity drugs starting in 2026. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/bridging-the-vaccination-gap-insights-on-global-immunization-challenges?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b3866b436b03effec592f24f29d5abcdde5990a8-2500x2500.jpg?fit=crop&auto=format" alt="Managed Care Cast Logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/bridging-the-vaccination-gap-insights-on-global-immunization-challenges?utm_source=www.ajmc.com&utm_medium=relatedContent">Bridging the Vaccination Gap: Insights on Global Immunization Challenges</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/bridging-the-vaccination-gap-insights-on-global-immunization-challenges?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with Jeffery A. Goad, PharmD, MPH, 2024-2025 president of the National Foundation for Infectious Diseases, on the recent report from the World Health Organization and UNICEF on public immunization rates, with national and global health implications.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3e5c760c89948ea062bc8055186b9134ab330099-3498x2332.jpg?fit=crop&auto=format" alt="Lonely patient | Image Credit: amazing studio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent">Social Isolation Linked to Increased Mortality in Patients With COPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Social isolation significantly increases the risk of mortality in patients with chronic obstructive pulmonary disease (COPD), highlighting the need for targeted interventions to address this issue.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/patients-with-hcc-may-avoid-additional-treatment-after-complete-response?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/144b5eb40a7906769a0da9c1a955868df95b72e1-7008x3942.jpg?fit=crop&auto=format" alt="Man holding liver illustration - SewcreamStudio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-hcc-may-avoid-additional-treatment-after-complete-response?utm_source=www.ajmc.com&utm_medium=relatedContent">Patients With HCC May Avoid Additional Treatment After Complete Response</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-hcc-may-avoid-additional-treatment-after-complete-response?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with locally advanced hepatocellular carcinoma (HCC) who achieve a complete response after locoregional therapy and immunotherapy may be able to follow a watch-and-wait protocol.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/venetoclax-may-be-an-option-for-children-with-r-r-aml-mds?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/75f5ad09048956408787303005237932f9707c3c-5433x2890.jpg?fit=crop&auto=format" alt="MDS wooden blocks held by hand in glove | Image Credit: © Sviatlana - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/venetoclax-may-be-an-option-for-children-with-r-r-aml-mds?utm_source=www.ajmc.com&utm_medium=relatedContent">Venetoclax May Be an Option for Children With R/R AML, MDS </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/venetoclax-may-be-an-option-for-children-with-r-r-aml-mds?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The single-center report showed the therapy had a favorable safety profile and manageable side effects in children with relapsed or refractory (R/R) acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent">Breaking the Cycle: The Importance of Early Intervention in Hidradenitis Suppurativa</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Prompt care supports mental well-being, as hidradenitis suppurativa is often associated with depression and anxiety due to its physical and social challenges.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6bd0e6a5c734135abb6fa97501b6375dc31df9c2-5600x3733.jpg?fit=crop&auto=format" alt="Medicare enrollment model | image credit: Vitalii Vodolazskyi - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent">New Proposal Aims to Expand Medicaid and Medicare Coverage for Obesity Drugs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">If made official, the proposed rule would give Part D and Medicaid beneficiaries expanded coverage to antiobesity drugs starting in 2026. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/bridging-the-vaccination-gap-insights-on-global-immunization-challenges?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b3866b436b03effec592f24f29d5abcdde5990a8-2500x2500.jpg?fit=crop&auto=format" alt="Managed Care Cast Logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/bridging-the-vaccination-gap-insights-on-global-immunization-challenges?utm_source=www.ajmc.com&utm_medium=relatedContent">Bridging the Vaccination Gap: Insights on Global Immunization Challenges</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/bridging-the-vaccination-gap-insights-on-global-immunization-challenges?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with Jeffery A. Goad, PharmD, MPH, 2024-2025 president of the National Foundation for Infectious Diseases, on the recent report from the World Health Organization and UNICEF on public immunization rates, with national and global health implications.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3e5c760c89948ea062bc8055186b9134ab330099-3498x2332.jpg?fit=crop&auto=format" alt="Lonely patient | Image Credit: amazing studio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent">Social Isolation Linked to Increased Mortality in Patients With COPD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/social-isolation-linked-to-increased-mortality-in-patients-with-copd?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Social isolation significantly increases the risk of mortality in patients with chronic obstructive pulmonary disease (COPD), highlighting the need for targeted interventions to address this issue.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/patients-with-hcc-may-avoid-additional-treatment-after-complete-response?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/144b5eb40a7906769a0da9c1a955868df95b72e1-7008x3942.jpg?fit=crop&auto=format" alt="Man holding liver illustration - SewcreamStudio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-hcc-may-avoid-additional-treatment-after-complete-response?utm_source=www.ajmc.com&utm_medium=relatedContent">Patients With HCC May Avoid Additional Treatment After Complete Response</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-hcc-may-avoid-additional-treatment-after-complete-response?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with locally advanced hepatocellular carcinoma (HCC) who achieve a complete response after locoregional therapy and immunotherapy may be able to follow a watch-and-wait protocol.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"What We’re Reading: Medicaid Coverage Errors; Gender Disparities in Health Research; Improved Lung Cancer Survival Rates","datePublished":"2023-11-14T16:22:48.496Z","dateModified":"2023-11-14T16:23:04Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/703de894e882d8a6da8c19964dc1ca71b969d30c-2000x1046.png?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/what-we-re-reading-medicaid-coverage-errors-gender-disparities-in-health-research-improved-lung-cancer-survival-rates"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"medicaid coverage errors,women's health initiative,healthcare disparities,lung cancer survival trends,Biden Administration health initiatives","articleBody":"Millions of America's Poorest at Risk of Losing Medicaid Coverage\n\nA report from Avalere reveals that up to 30 million of the most vulnerable Americans may lose Medicaid coverage due to flawed state reviews, with issues ranging from prolonged wait times in Florida to confusing paperwork in Arkansas, according to The Associated Press. Despite warnings from poverty experts, the Biden administration is accused of not effectively intervening. Advocates fear systemic problems are being ignored, pointing to procedural disenrollments, erroneous removals, and a lack of transparency in the reevaluation process.\n\n\n\nAdministration Seeks to Address Gender Disparities in Health Research\n\nThe Biden administration, led by First Lady Jill Biden, is launching a new initiative to address the longstanding neglect of women's health in research, giving officials 45 days to propose specific actions for improvement, according to USA Today. Carolyn M. Mazure, PhD, a renowned expert in women's health from Yale University, will lead the initiative, focusing on critical areas such as heart attacks and menopause. Despite progress since the establishment of the National Institutes of Health's Office of Research on Women’s Health in 1990, significant gaps persist, with conditions like Alzheimer disease and heart disease disproportionately affecting women but receiving inadequate research funding.\n\n\n\nEncouraging Trends in Lung Cancer Survival Rates for Marginalized Communities\n\nA recent survey by the American Lung Association indicates a positive shift in lung cancer survival rates, particularly among historically marginalized communities, despite ongoing racial disparities in health care, according to NPR. The 5-year survival rate for lung cancer increased by 22% from 2015 to 2019, reaching 26.6% across all racial and ethnic groups. Notably, people of color experienced a 17% improvement in survival rates between 2017 and 2019, now standing at 23.7%. Despite the progress, disparities persist, with varying survival rates among different racial groups, highlighting the need for continued efforts to address health care inequities.","description":"Up to 30 million individuals could lose Medicaid coverage; a new initiative demands increased focus on women's health issues; survey reports increased 5-year lung cancer survival rates from 2015 to 2019.","author":[{"@type":"Person","name":"AJMC Staff"}]}</script></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto 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The 5-year survival rate for lung cancer increased by 22% from 2015 to 2019, reaching 26.6% across all racial and ethnic groups. Notably, people of color experienced a 17% improvement in survival rates between 2017 and 2019, now standing at 23.7%. 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The report was ","_key":"a1ac0c58f3930"},{"_type":"span","marks":["738e3e3a1fff"],"text":"published in the ","_key":"a1ac0c58f3931"},{"_type":"span","marks":["f1d5a281df7f","em"],"text":"British Journal of Haemaotology","_key":"a1ac0c58f3932"},{"_type":"span","marks":[],"text":".","_key":"a1ac0c58f3933"},{"_type":"span","marks":["superscript"],"text":"1","_key":"1dfc28099771"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"There is no universal standard of care in R/R AML, noted corresponding author Sophie Cousson, MD, of the Robert Debré Academic Hospital, in Paris, and colleagues. The BCL-2 inhibitor venetoclax has become a first-line option in combination with hypomethylating agents (HMAs) or low-dose cytarabine in certain adults with newly diagnosed AML, gaining FDA approval in 2018.","_key":"57cf581bdb5d0"}],"_type":"block","style":"normal","_key":"86dab1b1cf4e"},{"alignment":"right","disableTextWrap":false,"disableLightBox":true,"imgcaption":[{"children":[{"_type":"span","marks":[],"text":"More research is needed to understand molecular determinants of response to venetoclax-based regimens. | Image Credit: © Sviatlana - stock.adobe.com","_key":"f901064811f90"}],"_type":"block","style":"normal","_key":"c572e73ad2c3","markDefs":[]}],"_key":"56f364ca54a5","_type":"figure","alt":"MDS wooden blocks held by hand in glove | Image Credit: © Sviatlana - stock.adobe.com","asset":{"_ref":"image-75f5ad09048956408787303005237932f9707c3c-5433x2890-jpg","_type":"reference"},"widthP":30},{"children":[{"_type":"span","marks":[],"text":"“This authorization has sparked interest in exploring venetoclax-based regimens for pediatric R/R leukemia,” Cousson and colleagues wrote.","_key":"6e968680d42f0"}],"_type":"block","style":"normal","_key":"6349b0d21481","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"They noted that a ","_key":"2b3d498342980"},{"_type":"span","marks":["c1e73108c11d"],"text":"2020 report","_key":"2b3d498342981"},{"_type":"span","marks":[],"text":" found venetoclax plus chemotherapy led to an overall response rate (ORR) of 80% (95% CI, 56%-94%) and a complete response (CR) rate of 70% (95% CI, 46%-88%) in pediatric patients with heavily relapsed and refractory AML treated with the recommended phase 2 dose of venetoclax of 360 mg/m","_key":"2b3d498342982"},{"marks":["superscript"],"text":"2","_key":"a52a59124b49","_type":"span"},{"_type":"span","marks":[],"text":".","_key":"8972e5760b0e"},{"_type":"span","marks":["superscript"],"text":"2","_key":"57da985937ce"}],"_type":"block","style":"normal","_key":"4ab476724e6f","markDefs":[{"_type":"link","href":"https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30060-7/fulltext","_key":"c1e73108c11d","nofollow":true,"blank":true}]},{"_key":"134d54202d28","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Subsequent research into pediatric use of venetoclax has shown that the therapy works best when combined with other therapeutic agents, has a favorable safety profile, and could be used as a bridge to allogeneic hematopoietic stem cell transplantation (allo-HSCT), Cousson and colleagues said.","_key":"e8685b012ae00"},{"_type":"span","marks":["superscript"],"text":"1","_key":"1c63a8f814ef"}],"_type":"block","style":"normal"},{"_key":"499084483a59","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In the new report, the investigators analyzed the cases of 12 patients, ranging in age from 2 to 12 years, who were given venetoclax-based regimens for R/R myeloid malignancies. Eight of the patients had previously experienced relapse, 5 patients were given venetoclax after allo-HSCT, and 3 patients had refractory AML, the authors said. One patient had MDS-related AML (MDS-AML), and the remainder had R/R AML.","_key":"0cc685bed3420"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"bac6a2e353d5","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The patients received either venetoclax plus HMAs (5 patients) or chemotherapy (5 patients) or venetoclax alone (2 patients). At a median follow-up of 11 months, the investigators said the ORR for the cohort was 41.6% and 33% of patients achieved CR.","_key":"4ca0bd0b76b30"}]},{"markDefs":[],"children":[{"text":"The CR rate was best (60%) in patients who received venetoclax plus cytotoxic agents. In those receiving venetoclax plus HMAs, just 1 patient achieved a complete response with incomplete recovery. Neither of the 2 patients on venetoclax monotherapy responded.","_key":"098b783de5ab0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"1b15ab29139a"},{"_key":"2bcb5a1bc0ba","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The 1-year overall survival rate was 50% (95% CI, 28%-88%), and 1-year event-free survival rate was 25% (95% CI, 9.4%-67%).","_key":"d5e6fbff6b0d0"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"By the end of follow-up, 11 patients had died. Most of the patients died as a result of progression or relapse (10 patients), but 1 patient died due to an infection associated with transplantation.","_key":"356bcb4614cc0","_type":"span"}],"_type":"block","style":"normal","_key":"fbbce19c3922"},{"markDefs":[],"children":[{"marks":[],"text":"Cousson and colleagues said the single-center nature of the study limits the conclusions that can be drawn from it, but they said the data still provide valuable insights. For instance, they noted that 4 patients achieved CR without using anthracyclines, and 3 of those patients were able to undergo HSCT.","_key":"554021fdf4ba0","_type":"span"}],"_type":"block","style":"normal","_key":"b2dca6780a6e"},{"_type":"block","style":"normal","_key":"db9a3c464d62","markDefs":[],"children":[{"_key":"6cc384cdf0520","_type":"span","marks":[],"text":"“This regimen could be particularly beneficial for heavily pretreated patients, allowing for less intensive treatment options,” they wrote."}]},{"markDefs":[],"children":[{"marks":[],"text":"They said their experience suggests a venetoclax-cytarabine-based regimen is a favorable bridging strategy to HSCT. In addition, they argued that more research is needed to understand molecular determinants of response to venetoclax-based regimens, and they said resistance-management strategies will need to be developed.","_key":"2b014e2005e30","_type":"span"}],"_type":"block","style":"normal","_key":"b3b7469cc2a1"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"“BLC2-inhibitors like venetoclax are promising targeted therapy in treating R/R myeloid disorders but significant research efforts and multicenter clinical trials are warranted to refine treatment strategies in these patients,” they concluded.","_key":"c3d8e9aae86f0"}],"_type":"block","style":"normal","_key":"1f96fb0b8058"},{"style":"normal","_key":"604c29ba8012","markDefs":[],"children":[{"_key":"300462bca79f0","_type":"span","marks":[],"text":""}],"_type":"block"},{"_type":"block","style":"normal","_key":"e979031f02b0","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"26ec3e41f5f80"}]},{"children":[{"_type":"span","marks":[],"text":"Cousson S, Calvo C, Goldwirt L, et al. Monocentric experience of venetoclax-based regimen in paediatric refractory and relapsed AML/MDS. ","_key":"e6974c0a598b0"},{"_type":"span","marks":["em"],"text":"Br J Haematol","_key":"2c108af9e70a"},{"_type":"span","marks":[],"text":". Published online October 24, 2024. doi:10.1111/bjh.19849","_key":"080f468bdc92"}],"level":1,"_type":"block","style":"normal","_key":"fef5e0247da6","listItem":"number","markDefs":[]},{"listItem":"number","markDefs":[],"children":[{"text":"Karol SE, Alexander TB, Budhraja A, et al. Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study. 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A single-center study involving 12 patients demonstrated an overall response rate of 41.6% and a complete response rate of 33%. The combination of venetoclax with cytotoxic agents yielded the highest complete response rate of 60%. The study highlights venetoclax's potential as a bridging therapy to hematopoietic stem cell transplantation. However, further research and multicenter trials are necessary to optimize treatment strategies and understand resistance mechanisms.","title":"Venetoclax May Be an Option for Children With R/R AML, MDS ","ExcludeFromPubMedXML":false,"articleType":"News","_rev":"qMZkEXqBAV3IRERLMAmluU","_updatedAt":"2024-11-22T21:22:17Z","authorMapping":[{"_type":"author","_id":"author_18c68a1fd690db471eba0e0da3b8e979","biography":[{"children":[{"marks":[],"text":"Jared is a freelance writer for The American Journal of Managed Care® (AJMC®), and previously worked as a senior editor for HCPLive® at MJH Life Sciences®.","_key":"e9f80bd7687c0","_type":"span"}],"_type":"block","style":"normal","_key":"75ff381b2d42","markDefs":[{"_type":"link","href":"https://www.linkedin.com/in/jaredkalt/","_key":"30c8f5445624"}]},{"style":"normal","_key":"a90d9599d615","markDefs":[{"blank":true,"_type":"link","href":"https://www.linkedin.com/in/jaredkalt/","_key":"30c8f5445624","nofollow":true}],"children":[{"_type":"span","marks":[],"text":"He has an MA from University of Sioux Falls. You can connect with Jared on ","_key":"95b8dd3e29db"},{"_type":"span","marks":["30c8f5445624"],"text":"LinkedIn","_key":"e9f80bd7687c1"},{"_type":"span","marks":[],"text":".","_key":"e9f80bd7687c2"}],"_type":"block"}],"_updatedAt":"2022-08-30T13:26:44Z","url":{"current":"jared-kaltwasser","_type":"slug"},"displayName":"Jared Kaltwasser","_createdAt":"2020-05-05T10:50:04Z","_rev":"0TowddpnSMVYA5OKF42uAM"}],"documentGroup":null,"documentGroupMapping":null,"summary":"The single-center report showed the therapy had a favorable safety profile and manageable side effects in children with relapsed or refractory (R/R) acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). 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Ahmad NN, Robinson S, Kennedy-Martin T, Poon JL, Kan H. Clinical outcomes associated with anti-obesity medications in real-world practice: a systematic literature review. ","_key":"3281cf8c1909"},{"_key":"53e3517b9e561","_type":"span","marks":["em"],"text":"Obes Rev"},{"_type":"span","marks":[],"text":". 2021;22(11):e13326. doi:10.1111/obr.13326","_key":"53e3517b9e562"}],"_type":"block","style":"normal","_key":"e53125d8e311"},{"style":"normal","_key":"095a182857ff","markDefs":[{"_type":"link","href":"https://www.kff.org/health-costs/poll-finding/kff-health-tracking-poll-may-2024-the-publics-use-and-views-of-glp-1-drugs/","_key":"0da77b3db3e3","nofollow":true,"blank":true}],"children":[{"_type":"span","marks":[],"text":"4. Montero A, Sparks G, Presiado M, Hamel L. KFF Health Tracking Poll May 2024: the public’s use and views of GLP-1 drugs. KFF. May 10, 2024. Accessed November 26, 2024. 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Also, about 1 in 5 people with COPD experience social isolation, which is about twice as much as older adults overall. The researchers attributed this increase in social isolation to disease features, like breathlessness and reduced physical function.","_key":"f3dab0502db60"}],"_type":"block","style":"normal","_key":"aaccb6b585f1","markDefs":[]},{"style":"normal","_key":"0a7af4acb511","markDefs":[],"children":[{"text":"","_key":"4751709591650","_type":"span","marks":[]}],"_type":"block"},{"style":"normal","_key":"d76bb7775fab","markDefs":[],"children":[{"marks":[],"text":"However, the association of social isolation in COPD with downstream outcomes, like mortality, has not been examined. 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Those with 3 points or more were classified as experiencing social isolation. The researchers noted that participants were included at the first available wave in which they self-reported COPD and answered at least 3 questions related to social isolation.","_key":"774bce287f390","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"36b241a75d00","markDefs":[]},{"markDefs":[],"children":[{"text":"","_key":"fe2f81665c4c0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"b08eb8c285c6"},{"children":[{"_type":"span","marks":[],"text":"All-cause mortality was determined using HRS date-of-death measures. Cox proportional hazard models were then used to determine the association between social isolation and all-cause mortality, adjusting for age, race, sex, and ethnicity, which have previously been associated with social isolation.","_key":"df4927f8fef80"}],"_type":"block","style":"normal","_key":"8ccf59deb9bb","markDefs":[]},{"_type":"block","style":"normal","_key":"dd06cf11b8c2","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"4ade442bd8d00"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The study population consisted of 1241 participants, with a mean (SD) age of 68.4 (9.8) years; the majority was female (59.3%). Of these participants, 293 (23.6%) reported experiencing social isolation. Additionally, 539 participants (43.4%) died after a median follow-up of 4.4 years (range, 0.1-14.6 years).","_key":"48351ba598330"}],"_type":"block","style":"normal","_key":"06ad69063af8"},{"style":"normal","_key":"56dae2dd0f40","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"894f2dfd41e70"}],"_type":"block"},{"_type":"block","style":"normal","_key":"9f7adc54e414","markDefs":[],"children":[{"marks":[],"text":"Those with COPD and social isolation were at an increased risk of death (unadjusted HR, 1.35; 95% CI, 1.08-169; adjusted HR, 1.35; 95% CI, 1.04-1.75) than those without social isolation. Therefore, median survival time was lower among socially isolated participants (7.0 years; 95% CI, 5.8-8.2) vs those not socially isolated (9.1 years; 95% CI, 8.3-10.4). Similarly, the 5-year survival rate among socially isolated participants (62.9%; 95% CI, 56.6-68.6) was lower than that of those not socially isolated (71.1%; 95% CI, 67.7-74.1).","_key":"9bfcb9e368860","_type":"span"}]},{"style":"normal","_key":"b9a96716f5b5","markDefs":[],"children":[{"marks":[],"text":"","_key":"8262dc6900c20","_type":"span"}],"_type":"block"},{"_type":"block","style":"normal","_key":"b625550b3317","markDefs":[],"children":[{"marks":[],"text":"“We hypothesize that social isolation may increase mortality risk in COPD by limiting access to necessary support and resources for managing debilitating symptoms such as breathlessness, functional limitations, and complex medical regimens, particularly after hospital or intensive care unit stays,” the authors wrote.","_key":"4046d8b0951f0","_type":"span"}]},{"style":"normal","_key":"80b317da5ebe","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"0d7d57967c140"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Consequently, the researchers emphasized that addressing social isolation through expanded interdisciplinary efforts could improve well-being and provide resources to help proactively plan for health crises. 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However, the study authors note, “This promising response presents a new challenge for clinicians regarding the optimal treatment” after patients achieve a complete response due to the lack of long-term outcomes data for these patients. The researchers conducted a post hoc analysis of the outcomes for these patients with HCC who received the combination of LRT and I/O. Patients in their study were diagnosed and treated at Queen Mary Hospital in Hong Kong, China; Tuen Mun Hospital, also in Hong Kong, China; or the University of Hong Kong-Shenzhen Hospital, in Shenzhen, China.","_key":"d396509285aa0"}],"_type":"block","style":"normal","_key":"516273fdddf6"},{"children":[{"_type":"span","marks":[],"text":"","_key":"70b5fe855f610"}],"_type":"block","style":"normal","_key":"a84852457a00","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"Patients were treated with transarterial chemoembolization (TACE) on day 1 followed by 5 fractions of stereotactic body radiotherapy (SBRT) on day 28 and I/O 14 days after SBRT and for every 2 weeks after. Patients were placed on close surveillance without surgical treatment if they achieved CR, and they underwent CT or MRI of the abdomen every 3 months and CT of the thorax every 4 to 6 months. Every 3 months, patients underwent a physical examination.","_key":"37b90965356b0","_type":"span"}],"_type":"block","style":"normal","_key":"d4b18a7e47e3"},{"children":[{"text":"","_key":"025ac964f28e0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"0fa6e4a7bf22","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"A total of 63 patients were included, with the majority (92.1%) being men and a median age of 69 years (range, 18-90 years). The median follow-up time was 34.7 months. There were 33 patients who received a combination of sequential TACE and SBRT followed by I/O; 16 patients who received combined TACE, SBRT, and I/O; and 14 patients who received SBRT combined with I/O.","_key":"e18bb6298e010"}],"_type":"block","style":"normal","_key":"d30e2c8b9242"},{"_key":"c4e5260b4a7f","markDefs":[],"children":[{"_key":"24a8d86661820","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Almost half (46.0%) of patients treated achieved a complete response, 28.6% achieved a partial response, 9.5% achieved stable disease, and 15.9% experienced disease progression. The median time to achieving a complete response was 5.4 months (95% CI, 4.7-7.3 months) and the median duration of the complete response was 25.7 months (95% CI, 23-6-36.3 months).","_key":"e2bbf16e06480"}],"_type":"block","style":"normal","_key":"cf6b44f7fcfc"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"82f86e4386820"}],"_type":"block","style":"normal","_key":"23bb993cd11e"},{"_type":"block","style":"normal","_key":"a6be43b56990","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Of the patients who achieved a complete response:","_key":"c54ebc62a7980"}]},{"_key":"5ade1401b983","listItem":"bullet","markDefs":[],"children":[{"_type":"span","marks":[],"text":"20.7% died due to HCC progression (n = 2), COVID-19 (n = 1), cardiac arrhythmia (n = 2), and cirrhosis (n = 1)","_key":"aef4a86e70890"}],"level":1,"_type":"block","style":"normal"},{"listItem":"bullet","markDefs":[],"children":[{"_type":"span","marks":[],"text":"34.5% of patients relapsed","_key":"bf0d138d65a10"}],"level":1,"_type":"block","style":"normal","_key":"7fae98eec5e6"},{"listItem":"bullet","markDefs":[],"children":[{"_type":"span","marks":[],"text":"6 patients had solitary intrahepatic disease relapse and received curative surgical treatment","_key":"0544763fab470"}],"level":2,"_type":"block","style":"normal","_key":"27e338839b20"},{"_key":"99d3c8f2b874","listItem":"bullet","markDefs":[],"children":[{"_type":"span","marks":[],"text":"4 patients had multifocal or disseminated disease and were treated with palliative intent","_key":"3d09e57cf7d00"}],"level":2,"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"Overall, the survival was “satisfactory” among the patients who achieved a complete response, the authors noted. The heterogeneity in the choice of LRT and I/O was one limitation of the study, as well as the lack of a control group. In addition, the generalizability of the study may be limited since 69.8% of the patients had hepatitis B–related HCC.","_key":"6f2d330f81430","_type":"span"}],"_type":"block","style":"normal","_key":"ec359c1dd5c5"},{"_key":"6e54a53f0a2f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The findings of this study indicate additional randomized clinical trials are warranted, they concluded.","_key":"2bf000b8ca370"}],"_type":"block","style":"normal"},{"_key":"c75f48cb5978","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"b7c5183508800"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"1. Chiang CL, Chan KSK, Chiu KWH, et al. Complete response to locoregional therapy plus immunotherapy for hepatocellular carcinoma. 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