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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9bfb813590bd81fd05291268884b87cd7cd5840a-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9bfb813590bd81fd05291268884b87cd7cd5840a-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9bfb813590bd81fd05291268884b87cd7cd5840a-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-contain" loading="lazy"/></noscript></span></a></div><div class="border-t-gray-100 border-t-2 flex-auto py-2 "><span class="text-sm text-gray-500 py-2">April 8th 2025</span><div class="py-3"><a class="lg:text-[20px] text-[19px] font-[500]" href="/view/worse-ctd-pah-prognosis-seen-with-higher-hfa-peff-score">Worse CTD-PAH Prognosis Seen With Higher HFA-PEFF Score</a></div><div class="pb-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/maggie-l-shaw"><i>Maggie L. Shaw</i></a></span></div></div><a href="/view/worse-ctd-pah-prognosis-seen-with-higher-hfa-peff-score"><a href="/view/worse-ctd-pah-prognosis-seen-with-higher-hfa-peff-score"><p class="mt-1 text-gray-800 text-[13px] line-clamp-6 text-hidden">The findings from this single-center retrospective study compare outcomes between 2 groups of patients living with connective tissue disease–associated pulmonary arterial hypertension (CTD-PAH) stratified by their Heart Failure Association–preserved ejection fraction (HFA-PEFF) algorithm score.</p></a></a></div></div><div class="flex-wrap w-[60%] flex "><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/burden-of-pah-weighs-heavy-worldwide"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="lg:object-cover object-contain " style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F7ec2f32190953478f27240757f4f4505b99f97c1-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F7ec2f32190953478f27240757f4f4505b99f97c1-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F7ec2f32190953478f27240757f4f4505b99f97c1-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F7ec2f32190953478f27240757f4f4505b99f97c1-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F7ec2f32190953478f27240757f4f4505b99f97c1-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F7ec2f32190953478f27240757f4f4505b99f97c1-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F7ec2f32190953478f27240757f4f4505b99f97c1-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F7ec2f32190953478f27240757f4f4505b99f97c1-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F7ec2f32190953478f27240757f4f4505b99f97c1-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="lg:object-cover object-contain " loading="lazy"/></noscript></span></div><div class="border-t-gray-100 border-t-2 pt-2 pb-2 flex-auto "><a href="/view/burden-of-pah-weighs-heavy-worldwide"><span class="text-sm text-gray-500">April 4th 2025</span></a><div><a class="text-[14px]" href="/view/burden-of-pah-weighs-heavy-worldwide"><p class="line-clamp-4 text-hidden font-[500]">Burden of PAH Weighs Heavy Worldwide</p></a></div><div class="py-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/maggie-l-shaw"><i>Maggie L. 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style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-cover" loading="lazy"/></noscript></span></div><div class="jsx-187450181 content-wrap"><span class="jsx-187450181 py-3 text-sm text-gray-500 text-left"><i class="jsx-187450181">May 6th 2024</i></span><div class="jsx-187450181 w-full h-fit mb-4"><p class="jsx-187450181 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Breaking Down the PAH Cost Burden</p></div></div></div></a><a target="" style="scroll-snap-align:center;text-decoration:none" class="jsx-609564708 sm:w-[280px] xs:w-[240px] w-[65%] h-auto flex flex-col space-y-3 flex-none select-none no-underline" href="/view/overcoming-limitations-and-barriers-associated-with-treating-pulmonary-arterial-hypertension"><div class="jsx-609564708 w-full h-full flex flex-col overflow-hidden relative bg-white text-center"><div class="jsx-609564708 relative w-full shadow-md shadow-grey-800 aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="object-cover" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F30b023bf97fd9d2e2d35ad9acda5dd83a0de246a-1920x1080.png%2FPrestonHS.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, 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class="jsx-609564708">May 3rd 2024</i></span><div class="jsx-609564708 w-full h-fit mb-4"><p class="jsx-609564708 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Overcoming Limitations and Barriers Associated with Treating Pulmonary Arterial Hypertension</p></div></div></div></a></div></div></div><div class="flex items-center space-x-4 border-0 border-b border-secondary select-none py-1"><h2 class="text-3xl text-primary">More News</h2></div><div class="flex flex-wrap w-full pb-4"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/pulmonary-hypertension-subtypes-show-distinct-pa-flow-hemodynamics"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/abacbfe95fc42fa3cf67fc7a9986403492534dec-1200x673.jpg?fit=crop&auto=format" alt="Patients with PAH had distinct PA flow characteristics compared with those with PH-HFpEF. | Image credit: Thirawat - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 21st 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/pulmonary-hypertension-subtypes-show-distinct-pa-flow-hemodynamics">Pulmonary Hypertension Subtypes Show Distinct PA Flow Hemodynamics</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/pulmonary-hypertension-subtypes-show-distinct-pa-flow-hemodynamics"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Investigators used 4D flow cardiovascular magnetic resonance imaging to search for differences between pulmonary artery (PA) remodeling in pulmonary arterial hypertension and other types of pulmonary hypertension.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/managing-pulmonary-hypertension-in-pregnancy"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a262f93cf247468963c7cfc985442126b8e04ded-1200x738.jpg?fit=crop&auto=format" alt="Measuring BP in pregnancy | Image Credit: ©Mediteraneo-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 18th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/managing-pulmonary-hypertension-in-pregnancy">Managing Pulmonary Hypertension in Pregnancy</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/managing-pulmonary-hypertension-in-pregnancy"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Pulmonary arterial hypertension (PAH) can be a challenging complication to manage during pregnancy; women with PAH who are pregnant are considered a high-risk population, and they face higher rates of maternal and fetal complications. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/pah-treatment-benefits-extend-to-patients-with-repaired-congenital-heart-disease"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6282615f1aff2ee6e737e536f2d2daf253168cf2-1200x738.jpg?fit=crop&auto=format" alt="Congenital heart disease | Image Credit: © ibreakstock-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 14th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/pah-treatment-benefits-extend-to-patients-with-repaired-congenital-heart-disease">PAH Treatment Benefits Extend to Patients With Repaired Congenital Heart Disease </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/pah-treatment-benefits-extend-to-patients-with-repaired-congenital-heart-disease"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Historical data show the prevalence of pulmonary arterial hypertension (PAH) in adult patients with congenital heart disease ranges from 4% to 28%, according to studies from the US and Europe—and that the prevalence of these comorbid condition is on the rise. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/high-uric-acid-appears-to-have-causal-role-in-pah"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/c8602c793d0ee860dce20e3b1d74f73c83dc7aa3-1198x799.jpg?fit=crop&auto=format" alt="Hyperuricemia may be an important risk factor for pulmonary arterial hypertension. | Image credit: jarun011 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 3rd 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/high-uric-acid-appears-to-have-causal-role-in-pah">High Uric Acid Appears to Have Causal Role in PAH</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/high-uric-acid-appears-to-have-causal-role-in-pah"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A Mendelian analysis supports the idea that hyperuricemia may be an important risk factor for pulmonary arterial hypertension (PAH). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/people-with-pah-report-higher-symptom-burden-than-their-physicians"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b7e48a9b1e2b67931327db42c03f879a57f62b3a-8256x4644.jpg?fit=crop&auto=format" alt="A new report suggests that patients with PAH consistently report higher symptom burden than their physicians do for their condition | image credit: bongkarn - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/people-with-pah-report-higher-symptom-burden-than-their-physicians">People With PAH Report Higher Symptom Burden Than Their Physicians </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/people-with-pah-report-higher-symptom-burden-than-their-physicians"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients and physicians agree about which symptoms have the biggest impact on patients’ quality of life.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-pah-articles-of-2024"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/24eb75914017d2e4344c7aed43a80ac74a8166ba-3187x1625.png?fit=crop&auto=format" alt="Top 5 PAH Articles of 2024" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-pah-articles-of-2024">Top 5 Most-Read PAH Articles of 2024</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/julia-bonavitacola">Julia Bonavitacola</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-pah-articles-of-2024"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The top articles about pulmonary arterial hypertension (PAH) in 2024 included FDA approvals, the effect of salt substitutes on hypertension, and how diagnosis time affects outcomes.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/researchers-characterize-limitations-with-methods-of-determining-ivs-flattening-in-ph"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/cb6c8b644f8a554ba8b07e492d6a83ef19029c1b-3840x2160.jpg?fit=crop&auto=format" alt="Heart | Image credit: appledesign - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/researchers-characterize-limitations-with-methods-of-determining-ivs-flattening-in-ph">Researchers Characterize Limitations With Methods of Determining IVS Flattening in PH</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-contributor">AJMC Contributor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/researchers-characterize-limitations-with-methods-of-determining-ivs-flattening-in-ph"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Based on their findings, the researchers suggest the integration of automated measures to identify interventricular septal (IVS) flattening in these patients.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/new-study-evaluates-quality-of-life-instruments-for-patients-with-pah"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/893f95a83a615fdabf1515ea6ac5b26014f89086-1200x738.jpg?fit=crop&auto=format" alt="PAH | Image Credit: © Kiattisak-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 12th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/new-study-evaluates-quality-of-life-instruments-for-patients-with-pah">New Study Evaluates Quality-of-Life Instruments for Patients With PAH</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kimberly-rath-pharmd">Kimberly Rath, PharmD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/new-study-evaluates-quality-of-life-instruments-for-patients-with-pah"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A systematic review of quality-of-life tools available specifically for pulmonary arterial hypertension (PAH) reveals that although several instruments demonstrate strong psychometric properties and reliability, significant gaps remain in these tools' validation and methodological rigor.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nanoparticle-delivery-holds-promise-for-treatment-of-pah"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/1dbaf49dcb9f19b92d18dc7e7b85bd779513e4ed-6144x3072.jpg?fit=crop&auto=format" alt="Lung analysis concept | image credit: Shahidah - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 8th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nanoparticle-delivery-holds-promise-for-treatment-of-pah">Nanoparticle Delivery Holds Promise for Treatment of PAH </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nanoparticle-delivery-holds-promise-for-treatment-of-pah"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Aerosolized vascular endothelial growth factor/stromal cell-derived factor-1α (VEGFNP/SDFNP) led to a lower pulmonary arterial pressure and prevented right ventricular hypertrophy after monocrotaline (MCT) injection in rats.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/slow-steady-advances-noninvasive-diagnosis-of-ph-in-ild-populations"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ef14eae02e6f30f8900edd20120b541d220c85d2-2438x2994.jpg?fit=crop&auto=format" alt="Chest X-ray for lung health assessment | image credit: Radiographys - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 5th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/slow-steady-advances-noninvasive-diagnosis-of-ph-in-ild-populations">Slow, Steady Advances: Noninvasive Diagnosis of PH in ILD Populations</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gayle-turim-dickstein">Gayle Turim Dickstein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/slow-steady-advances-noninvasive-diagnosis-of-ph-in-ild-populations"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Many roadblocks exist to detecting and assessing pulmonary hypertension (PH) in patients with interstitial lung disease (ILD), but creative thinking and artificial intelligence (AI) may soon help improve the landscape. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/communication-can-boost-medication-persistence-in-pah"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3ced4458e3d985cfb967a200a91ac26fcd8e1247-6720x3780.jpg?fit=crop&auto=format" alt="patient taking pills | Image Credit: © fizkes - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/communication-can-boost-medication-persistence-in-pah">Communication Can Boost Medication Persistence in PAH</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/communication-can-boost-medication-persistence-in-pah"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients continued taking their medications for pulmonary arterial hypertension (PAH) when symptoms appeared to improve, according to a new survey.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/why-right-heart-catheterization-confirming-pah-diagnosis-may-be-underperformed"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f790c06e47da30e93dd39ee83236edd8a871cc66-1200x724.jpg?fit=crop&auto=format" alt="Doctor with hands holding an image of lungs | Image credit: Orawan - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/why-right-heart-catheterization-confirming-pah-diagnosis-may-be-underperformed">Why Right Heart Catheterization Confirming PAH Diagnosis May Be Underperformed</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gayle-turim-dickstein">Gayle Turim Dickstein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/why-right-heart-catheterization-confirming-pah-diagnosis-may-be-underperformed"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Professional guidelines say that when pulmonary arterial hypertension (PAH) is diagnosed, right heart catheterization should be performed, but a quarter of the time, it isn’t—so investigators set out to discover why.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/poor-sleep-quality-associated-with-pulmonary-arterial-hypertension"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/c64aba3fe6a6af601ec52548d146d692aca94792-6000x4000.jpg?fit=crop&auto=format" alt="Patients with PAH may experience issues with sleep | image credit: princeoflove - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 14th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/poor-sleep-quality-associated-with-pulmonary-arterial-hypertension">Poor Sleep Quality Associated With Pulmonary Arterial Hypertension </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/poor-sleep-quality-associated-with-pulmonary-arterial-hypertension"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Most patients with pulmonary arterial hypertension (PAH) suffered from poor sleep quality, and dyspnea was a significant predictor of sleep quality, independent of disease severity, according to this study. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/refinements-to-european-strategy-can-improve-pah-chd-stratification"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/691ecebc9ecf2884c4a59c490d9e0a67cdbf995f-5388x3592.jpg?fit=crop&auto=format" alt="patient and doctor - Halfpoint - stock.adobe.com.jpeg" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 6th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/refinements-to-european-strategy-can-improve-pah-chd-stratification">Refinements to European Strategy Can Improve PAH-CHD Stratification</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-contributor">AJMC Contributor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/refinements-to-european-strategy-can-improve-pah-chd-stratification"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">When patients were re-classified based on the adjusted thresholds of N-terminal pro-brain natriuretic peptide and 6-minute walk distance and the inclusion of TAPSE rather than right atria area, classification of patients improved significantly. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/pah-treatment-outcomes-similar-regardless-of-diagnosis-time"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a2168958a2d447b082e5ce3b2261fe93ea2a415e-1200x738.jpg?fit=crop&auto=format" alt="Pulmonary hypertension | Image Credit: © Designpics - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 1st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/pah-treatment-outcomes-similar-regardless-of-diagnosis-time">PAH Treatment Outcomes Similar Regardless of Diagnosis Time</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-contributor">AJMC Contributor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/pah-treatment-outcomes-similar-regardless-of-diagnosis-time"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The study findings underscore the importance of early initiation of macitentan and tadalafil among patients who have pulmonary arterial hypertension (PAH), and represent a shift in understanding of prognosis based on diagnosis timing. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/early-use-of-triple-oral-therapy-may-lower-hospitalizations-for-pah"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/0b83ef12615db4036e511cced4db562b28988436-5376x3584.jpg?fit=crop&auto=format" alt="PAH concept | image credit: Ahmad - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/early-use-of-triple-oral-therapy-may-lower-hospitalizations-for-pah">Early Use of Triple Oral Therapy May Lower Hospitalizations for PAH </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-contributor">AJMC Contributor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/early-use-of-triple-oral-therapy-may-lower-hospitalizations-for-pah"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The comparative effectiveness study found that the addition of selexipag (Uptravi) to double oral therapy (DOT) reduced the risk of patients being hospitalized or having their disease progress. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/certain-immune-cells-may-increase-decrease-pah-risk"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f790c06e47da30e93dd39ee83236edd8a871cc66-1200x724.jpg?fit=crop&auto=format" alt="Doctor holds lung model representing PAH | Image Credit: © Orawan - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/certain-immune-cells-may-increase-decrease-pah-risk">Certain Immune Cells May Increase, Decrease PAH Risk</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gayle-turim-dickstein">Gayle Turim Dickstein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/certain-immune-cells-may-increase-decrease-pah-risk"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Using Mendelian randomization analysis, researchers found evidence that 2 small groups of immunophenotypes are linked to either greater or lesser odds of developing pulmonary arterial hypertension (PAH). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/a-call-for-consistent-digital-mobility-measurement-protocols-in-pah"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/cb513dead47dcfcfe22eebd5dd2bde53c2bddc57-5504x3669.jpg?fit=crop&auto=format" alt="Mobility reduction may be an early sign of PAH | image credit: PrusarooYakk - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 9th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/a-call-for-consistent-digital-mobility-measurement-protocols-in-pah">A Call for Consistent Digital Mobility Measurement Protocols in PAH</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gayle-turim-dickstein">Gayle Turim Dickstein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/a-call-for-consistent-digital-mobility-measurement-protocols-in-pah"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">As more researchers utilize digital technology to measure mobility in pulmonary arterial hypertension (PAH), a team calls for consistent protocols to make outcomes as meaningful as possible to patients and clinicians </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/complementary-therapies-improve-quality-of-life-in-ph"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/03c85c5bc15beeceebf80f56ae77fe37cbc0ca88-1200x728.jpg?fit=crop&auto=format" alt="Carboard cutout of lungs with a stethoscope and the words Pulmonary Hypertension | Image credit: Dzmitry - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 4th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/complementary-therapies-improve-quality-of-life-in-ph">Complementary Therapies Improve Quality of Life in PH</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gwen-mergian">Gwen Mergian</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/complementary-therapies-improve-quality-of-life-in-ph"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Initial evidence suggests alternative approaches such as exercise, dietary modification, and psychosocial therapies may enhance traditional management of pulmonary hypertension.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/combined-chemotherapy-and-immunotherapy-improves-outcomes-in-pah"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/34a595461e45614e9e2c58af2bb2d0a24df38fa6-3600x2400.jpg?fit=crop&auto=format" alt="Human lungs on scientific background | Image Credit: © Crystal light - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/combined-chemotherapy-and-immunotherapy-improves-outcomes-in-pah">Combined Chemotherapy and Immunotherapy Improves Outcomes in PAH </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gwen-mergian">Gwen Mergian</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/combined-chemotherapy-and-immunotherapy-improves-outcomes-in-pah"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">An adult patient with pulmonary arterial hypertension (PAH) and metastatic lung adenocarcinoma showed significant clinical improvement when chemotherapy and immunotherapy were added to PAH triple therapy. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/comorbidities-require-special-treatment-consideration-for-pah"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/c7f265d6b135af4626c69fa8c0a7761d72ef4ac3-5926x3951.jpg?fit=crop&auto=format" alt="Man holding paper model of lungs | Image credit: Elena - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/comorbidities-require-special-treatment-consideration-for-pah">Comorbidities Require Special Treatment Consideration for PAH</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-contributor">AJMC Contributor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/comorbidities-require-special-treatment-consideration-for-pah"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In addition to being diagnosed more frequently in older patients, pulmonary arterial hypertension (PAH) is more frequently diagnosed in patients with cardio-pulmonary comorbidities, which poses challenges to the optimal treatment of PAH, explained the researchers.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/sotatercept-gains-european-approval-for-pah-for-use-with-other-treatments"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/aa6736b495b1425dc2eb1563b15a586acd757c14-6000x4000.jpg?fit=crop&auto=format" alt="Months after the FDA's approval of sotatercept for treating PAH, the drug has gained European approval | image credit: wladimir1804 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 11th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/sotatercept-gains-european-approval-for-pah-for-use-with-other-treatments">Sotatercept Gains European Approval for PAH for Use With Other Treatments </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-contributor">AJMC Contributor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/sotatercept-gains-european-approval-for-pah-for-use-with-other-treatments"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The European approval comes months after the FDA’s approval of the first-of-its-kind treatment for pulmonary arterial hypertension (PAH). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/inhaled-pah-therapy-gets-tentative-go-ahead-from-fda"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/c95ae87950c4cb9432fb0ac0f5c782e6bde6edb3-4600x2944.jpg?fit=crop&auto=format" alt="FDA | image credit: Araki Illustrations - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 5th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/inhaled-pah-therapy-gets-tentative-go-ahead-from-fda">Inhaled PAH Therapy Gets Tentative Go-Ahead From FDA </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/inhaled-pah-therapy-gets-tentative-go-ahead-from-fda"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The tentative approval cannot take effect because a competing product was granted market exclusivity. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/cpap-treatment-can-significantly-reduce-hypertensive-adverse-outcomes-in-pregnancy"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/464a58d6276d89c16a484f91d2a27668f28e531e-5624x3749.jpg?fit=crop&auto=format" alt="CPAP therapy can reduce the risk of hypertension during pregnancy | image credit: sokko_natalia - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/cpap-treatment-can-significantly-reduce-hypertensive-adverse-outcomes-in-pregnancy">CPAP Treatment Can Significantly Reduce Hypertensive Adverse Outcomes in Pregnancy</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gayle-turim-dickstein">Gayle Turim Dickstein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/cpap-treatment-can-significantly-reduce-hypertensive-adverse-outcomes-in-pregnancy"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">When women with obstructive sleep apnea (OSA) carrying high-risk pregnancies collaborate with their health care providers to find the best individualized continuous positive airway pressure (CPAP) treatment, their risks of gestational hypertension and preeclampsia may drop appreciably</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/circulating-hmgb1-not-a-reliable-biomarker-in-pediatric-pah"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4a206763b4a225c8f01ad56f7d20f2332834bcba-3030x2018.jpg?fit=crop&auto=format" alt="Clinician listening to child's heartbeat | image credit: Maria Sbytova - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/circulating-hmgb1-not-a-reliable-biomarker-in-pediatric-pah">Circulating HMGB1 Not a Reliable Biomarker in Pediatric PAH</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/circulating-hmgb1-not-a-reliable-biomarker-in-pediatric-pah"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Though circulating high mobility group box-1 levels appear to be a biomarker for pulmonary arterial hypertension (PAH) in adults with congenital heart disease, the same is not true in pediatric patients.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fruit-and-vegetables-outperform-medication-and-baking-soda-to-treat-hypertension"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/09611c2abe336f9106591bacc303fa1b4bb261b5-7036x3958.jpg?fit=crop&auto=format" alt="Fruits and vegetable intake provides proven benefits for patients with hypertension | image credit: peangdao - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fruit-and-vegetables-outperform-medication-and-baking-soda-to-treat-hypertension">Fruit and Vegetables Outperform Medication and Baking Soda to Treat Hypertension </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fruit-and-vegetables-outperform-medication-and-baking-soda-to-treat-hypertension"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with hypertension-related chronic kidney disease who increased daily fruit and vegetable consumption showed improved cardiovascular health and reduced blood pressure compared with participants who added baking soda to their diet or who received pharmacological-only treatment. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/hypertensive-disorders-of-pregnancy-on-the-rise-in-canada"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/337a366c21fa614d1a9dc429594023c300aed68a-1200x800.jpg?fit=crop&auto=format" alt="hypertension in pregnancy | Image Credit: peopleimages.com-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 4th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/hypertensive-disorders-of-pregnancy-on-the-rise-in-canada">Hypertensive Disorders of Pregnancy on the Rise in Canada</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gayle-turim-dickstein">Gayle Turim Dickstein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/hypertensive-disorders-of-pregnancy-on-the-rise-in-canada"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Researchers don’t fully understand why these disorders are increasing, but they declare that finding out should be a top priority. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/early-treatment-may-help-prevent-pah-in-high-risk-patients"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e3284e83dcf7872473c93b62f55efdea0e892835-1200x738.jpg?fit=crop&auto=format" alt="representation of pulmonary hypertension | Image Credit: Angelov-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 31st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/early-treatment-may-help-prevent-pah-in-high-risk-patients">Early Treatment May Help Prevent PAH in High-Risk Patients</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-contributor">AJMC Contributor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/early-treatment-may-help-prevent-pah-in-high-risk-patients"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">New data from the single-center, open-label extension EDITA-ON study suggest that early treatment for pulmonary arterial hypertension (PAH) could benefit patients with systemic sclerosis and early pulmonary vascular disease.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/high-costs-hospitalizations-linked-to-ph-ild"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg?fit=crop&auto=format" alt="doc reviewing lung report | Image Credit: meeboonstudio-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 28th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/high-costs-hospitalizations-linked-to-ph-ild">High Costs, Hospitalizations Linked to PH, ILD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/high-costs-hospitalizations-linked-to-ph-ild"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The hospitalization rate for patients with pulmonary hypertension (PH) and interstitial lung disease (ILD) doubled over a 2-year period, and total health care costs more than doubled over the same period. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/cteph-treatment-management-varies-widely-across-globe"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/03c85c5bc15beeceebf80f56ae77fe37cbc0ca88-1200x728.jpg?fit=crop&auto=format" alt="pulmonary hypertension graphic | Image Credit: Dzmitry - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/cteph-treatment-management-varies-widely-across-globe">CTEPH Treatment, Management Varies Widely Across Globe</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/cteph-treatment-management-varies-widely-across-globe"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A new report shows wide variability in terms of which patients with chronic thromboembolic pulmonary hypertension (CTEPH) are deemed eligible for pulmonary endarterectomy and balloon pulmonary angioplasty.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/pah?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/pah?page=2">2</a><a class="px-4 py-2 border-y border-r " href="/compendium/pah?page=3">3</a><a class="px-4 py-2 border-y border-r " href="/compendium/pah?page=4">4</a><a class="px-4 py-2 border-y border-r " href="/compendium/pah?page=5">5</a><a class="px-4 py-2 border-y border-r " href="/compendium/pah?page=6">6</a><a class="px-4 py-2 border-y border-r " href="/compendium/pah?page=7">7</a><a class="px-4 py-2 border-y border-r " href="/compendium/pah?page=8">8</a><div class="px-4 py-2 border-y border-r">...</div><a class="px-4 py-2 border-y border-r" href="/compendium/pah?page=9">9</a><a class="px-4 py-2 border-y border-r" href="/compendium/pah?page=2">></a></div></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div class="bg-[#00598D] xl:w-[70%] w-[70%] py-12 pl-auto"><div class="xxl:w-[75%] w-[90%] ml-auto"><div><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span 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At a median follow-up of 10.6 months, 17.4% of patients on sotatercept experienced serious events, compared with 54.7% in the placebo group."}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"c179f05dbb18","markDefs":[],"children":[{"text":"","_key":"0f0782b1c300","_type":"span","marks":[]}]},{"_type":"block","style":"normal","_key":"11c4fb25c542","markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"This transcript was lightly edited; captions were auto-generated.","_key":"2a61b60808fa"}]},{"_key":"723244903b97","markDefs":[],"children":[{"_key":"418a257a81bc","_type":"span","marks":["strong","underline"],"text":"Transcript"}],"_type":"block","style":"normal"},{"style":"normal","_key":"356668f8ba33","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"The ZENITH trial was stopped early due to overwhelming efficacy. Can you share the key findings that led to this decision?","_key":"caf6431de2c7"}],"_type":"block"},{"_key":"30b795f36ec2","markDefs":[],"children":[{"marks":[],"text":"It is very important in the ZENITH trial to bear in mind that there was an interim analysis after 59, plus or minus 3, events. Thanks to this interim analysis, it appeared very clear that the primary end point was very much improved on sotatercept as compared to placebo. And based on that and for ethical reasons, the study was terminated. It is really the first time in our field that a phase 3 randomized controlled trial is terminated for efficacy at interim analysis.","_key":"2a94bce299c7","_type":"span"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"5019e7fccf6c","markDefs":[],"children":[{"text":"","_key":"4c234b7b061b","_type":"span","marks":[]}]},{"_key":"2a8c3aff9987","markDefs":[],"children":[{"_key":"48628390912b","_type":"span","marks":["strong"],"text":"Given the success of ZENITH, what are the next steps for sotatercept in terms of regulatory approval and potential clinical use?"}],"_type":"block","style":"normal"},{"children":[{"_key":"eb3689d3f926","_type":"span","marks":[],"text":"It's important to bear in mind that sotatercept is currently approved for PAH, but in some regions, people with advanced PAH are not really in the focus of the label. Thanks to that study, it will certainly be possible to extend the label for patients with advanced PAH and a higher risk of death. Now, there are many studies on sotatercept trying to cover the full landscape of PAH situations, and we know from the first phase 3 trial that this drug is important and improves exercise capacity and delays time to clinical worsening in people with functional class 2 or 3 of PAH. 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