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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9d6916e6d1c04c5bd3340cbec88ae0d3bb38a9bf-8037x5358.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9d6916e6d1c04c5bd3340cbec88ae0d3bb38a9bf-8037x5358.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9d6916e6d1c04c5bd3340cbec88ae0d3bb38a9bf-8037x5358.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9d6916e6d1c04c5bd3340cbec88ae0d3bb38a9bf-8037x5358.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9d6916e6d1c04c5bd3340cbec88ae0d3bb38a9bf-8037x5358.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9d6916e6d1c04c5bd3340cbec88ae0d3bb38a9bf-8037x5358.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-contain" loading="lazy"/></noscript></span></a></div><div class="border-t-gray-100 border-t-2 flex-auto py-2 "><span class="text-sm text-gray-500 py-2">February 18th 2025</span><div class="py-3"><a class="lg:text-[20px] text-[19px] font-[500]" href="/view/ovarian-cancer-outcomes-linked-to-preoperative-immunonutritional-status">Ovarian Cancer Outcomes Linked to Preoperative Immunonutritional Status</a></div><div class="pb-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/brooke-mccormick"><i>Brooke McCormick</i></a></span></div></div><a href="/view/ovarian-cancer-outcomes-linked-to-preoperative-immunonutritional-status"><a href="/view/ovarian-cancer-outcomes-linked-to-preoperative-immunonutritional-status"><p class="mt-1 text-gray-800 text-[13px] line-clamp-6 text-hidden">In patients with early-stage ovarian cancer, a high prognostic nutritional index improved survival, while a high systemic immune-inflammation index worsened it. In advanced stages, both affected overall survival but not progression-free survival.</p></a></a></div></div><div class="flex-wrap w-[60%] flex "><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/high-prevalence-of-sarcopenia-identified-in-patients-with-ovarian-endometrial-cancer"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="lg:object-cover object-contain " style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="" sizes="100vw" 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loading="lazy"/></noscript></span></div><div class="jsx-2915913710 content-wrap"><span class="jsx-2915913710 py-3 text-sm text-gray-500 text-left"><i class="jsx-2915913710">February 3rd 2025</i></span><div class="jsx-2915913710 w-full h-fit mb-4"><p class="jsx-2915913710 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden"> Olaparib Leads PARP Inhibitors in Boosting OS for Platinum-Sensitive Recurrent Ovarian Cancer</p></div><div class="jsx-2915913710 pb-2 text-left ]"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/brooke-mccormick"><i>Brooke McCormick</i></a></span></div></div></div></div></a><a target="" style="scroll-snap-align:center;text-decoration:none" class="jsx-2363373513 sm:w-[280px] xs:w-[240px] w-[65%] h-auto flex flex-col space-y-3 flex-none select-none no-underline" href="/view/niraparib-extends-pfs-time-to-next-treatment-in-patients-with-eoc-especially-brca-mutated-cases"><div class="jsx-2363373513 w-full h-full flex flex-col overflow-hidden relative bg-white text-center"><div class="jsx-2363373513 relative w-full shadow-md shadow-grey-800 aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="object-cover" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="" sizes="100vw" 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loading="lazy"/></noscript></span></div><div class="jsx-2363373513 content-wrap"><span class="jsx-2363373513 py-3 text-sm text-gray-500 text-left"><i class="jsx-2363373513">January 28th 2025</i></span><div class="jsx-2363373513 w-full h-fit mb-4"><p class="jsx-2363373513 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden"> Niraparib Extends PFS, Time to Next Treatment in Patients With EOC, Especially BRCA-Mutated Cases</p></div><div class="jsx-2363373513 pb-2 text-left ]"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/brooke-mccormick"><i>Brooke McCormick</i></a></span></div></div></div></div></a></div></div></div></div></div><div class="py-8 border-b-[2px] border-[#EEE]"><div class="relative w-full h-full max-w-[984px] rounded-md mx-auto"><div class="flex flex-col-reverse lg:flex-row items-center justify-center mx-auto rounded-md"><div class="w-full lg:w-[610px] xl:w-3/4 h-[280px] xs:h-[260px] sm:h-[250px] lg:h-[243px] xl:h-[311px] pb-[90px] pt-2 sm:pt-4 lg:pt-3 xl:pt-4 pl-3 xs:pl-4 sm:pl-6 pr-3 rounded-tl-none lg:rounded-tl-md rounded-bl-md rounded-br-md lg:rounded-br-none" style="background:var(--primary)"><h2 class="text-md sm:text-lg xl:text-xl leading-tight lg:leading-none xl:sleading-tight text-white font-bold font-lora my-2">Ovarian Cancer Guideline Updates 2024</h2><p class=" font-light font-rubik text-white text-xs xl:text-sm">Ronald D. Alvarez, MD, MBA, analyzes recent changes to NCCN guidelines for ovarian cancer care and provides updates on the latest clinical trial data.</p><div style="color:var(--primary)"><a class="font-bold font-rubik text-xs flex items-center gap-2 mt-2.5 xs:mt-4 lg:mt-2.5 xl:mt-3.5 py-2 px-3 cursor-pointer max-w-fit bg-white hover:bg-gray-300 rounded-md" href="https://bit.ly/4eRUHgx">Visit Now</a></div></div><div class="w-full max-h-[385px] lg:max-h-[243px] xl:max-h-[311px] overflow-hidden flex justify-center items-center rounded-br-none rounded-tr-md rounded-tl-md lg:rounded-r-md lg:rounded-tl-none pointer-events-none"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%27959%27%20height=%27539.5%27/%3e"/></span><img alt="Ronald D. 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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa7cdc93847d14bd04f1142ef907c75b3d94752a8-643x361.png%2FMonk3.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa7cdc93847d14bd04f1142ef907c75b3d94752a8-643x361.png%2FMonk3.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa7cdc93847d14bd04f1142ef907c75b3d94752a8-643x361.png%2FMonk3.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa7cdc93847d14bd04f1142ef907c75b3d94752a8-643x361.png%2FMonk3.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa7cdc93847d14bd04f1142ef907c75b3d94752a8-643x361.png%2FMonk3.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa7cdc93847d14bd04f1142ef907c75b3d94752a8-643x361.png%2FMonk3.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa7cdc93847d14bd04f1142ef907c75b3d94752a8-643x361.png%2FMonk3.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-cover" loading="lazy"/></noscript></span></div><div class="jsx-609564708 content-wrap"><span class="jsx-609564708 py-3 text-sm text-gray-500 text-left"><i class="jsx-609564708">December 24th 2020</i></span><div class="jsx-609564708 w-full h-fit mb-4"><p class="jsx-609564708 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Dr Bradley Monk on Multidisciplinary Care With PARP Inhibitors</p></div></div></div></a></div></div></div><div class="flex items-center space-x-4 border-0 border-b border-secondary select-none py-1"><h2 class="text-3xl text-primary">More News</h2></div><div class="flex flex-wrap w-full pb-4"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/real-world-study-highlights-parp-inhibitor-challenges-in-ovarian-cancer-care"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/51a9cd51ca636c64f5f4816707684ec6300edc2e-4500x3000.jpg?fit=crop&auto=format" alt="Ovarian cancer awareness illustration | Image Credit: Queenmoonlite Studio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 23rd 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/real-world-study-highlights-parp-inhibitor-challenges-in-ovarian-cancer-care">Real-World Study Highlights PARP Inhibitor Challenges in Ovarian Cancer Care</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/real-world-study-highlights-parp-inhibitor-challenges-in-ovarian-cancer-care"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Nearly half of patients with advanced ovarian cancer treated with first-line poly-ADP-ribose polymerase (PARP) inhibitors experienced recurrence in this real-world study, emphasizing the need for enhanced strategies to optimize postrecurrence treatment. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/gynecologic-oncology-practices-evolve-with-surgical-de-escalation-trends"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/7a4e9320fea64b1c6d9c3b4c5c3fdc80fa1d506b-5328x3552.jpg?fit=crop&auto=format" alt="Surgeon team performing an operation | Image Credit: Georgii - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 21st 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/gynecologic-oncology-practices-evolve-with-surgical-de-escalation-trends">Gynecologic Oncology Practices Evolve With Surgical De-Escalation Trends</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/gynecologic-oncology-practices-evolve-with-surgical-de-escalation-trends"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Researchers identified a 15-year shift toward surgical de-escalation in gynecologic oncology, marked by fewer surgical interventions, increased adoption of minimally invasive techniques, and a greater focus on fertility preservation and sentinel lymph node procedures.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/ai-outperforms-traditional-methods-in-predicting-ovarian-cancer-surgery-outcomes"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a1ac1ae65e3b131f710371a3f6ca36f8c6b07400-8984x3760.jpg?fit=crop&auto=format" alt="AI illustration | Image Credit: putilov_denis - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 19th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/ai-outperforms-traditional-methods-in-predicting-ovarian-cancer-surgery-outcomes">AI Outperforms Traditional Methods in Predicting Ovarian Cancer Surgery Outcomes</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/ai-outperforms-traditional-methods-in-predicting-ovarian-cancer-surgery-outcomes"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Artificial intelligence (AI) models, particularly artificial neural networks and machine learning, outperform traditional methods in predicting post–complete cytoreduction outcomes in patients with ovarian cancer, including overall survival, no residual disease, and postoperative complications. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/high-hsp60-expression-signals-poor-prognosis-aggressive-tumors-in-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ddd14ebd63edf0da6fdaebf551326f4821fc5491-3840x2160.jpg?fit=crop&auto=format" alt="Ovarian cancer animation | Image Credit: MohammedElAmine - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 16th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/high-hsp60-expression-signals-poor-prognosis-aggressive-tumors-in-ovarian-cancer">High HSP60 Expression Signals Poor Prognosis, Aggressive Tumors in Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/high-hsp60-expression-signals-poor-prognosis-aggressive-tumors-in-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">High heat shock protein 60 (HSP60) expression in patients with ovarian cancer is associated with larger tumors, advanced stages, and worse survival outcomes, highlighting its potential as a prognostic biomarker.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/niraparib-improves-outcomes-in-patients-with-stage-iii-eoc-no-visible-residual-disease"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a278bd0722aa52ec86e89be6263a0a27d7017fb9-4241x2829.jpg?fit=crop&auto=format" alt=" Physician holding niraparib box | Image Credit: luchschenF - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 14th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/niraparib-improves-outcomes-in-patients-with-stage-iii-eoc-no-visible-residual-disease">Niraparib Improves Outcomes in Patients With Stage III EOC, No Visible Residual Disease</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/niraparib-improves-outcomes-in-patients-with-stage-iii-eoc-no-visible-residual-disease"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with stage III epithelial ovarian cancer (EOC) and no visible residual disease after primary cytoreductive surgery had significantly longer real-world progression-free survival and time to next treatment when treated with first-line maintenance niraparib compared with those with higher-risk disease.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nomogram-predicts-overall-survival-in-patients-with-ovarian-cancer-liver-metastases"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/36eab7a94b6d17fc0eb189ea3161c764d52a759b-6000x4000.jpg?fit=crop&auto=format" alt="Ovarian cancer animation | Image Credit: Dr_Microbe - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 9th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nomogram-predicts-overall-survival-in-patients-with-ovarian-cancer-liver-metastases">Nomogram Predicts Overall Survival in Patients With Ovarian Cancer, Liver Metastases</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nomogram-predicts-overall-survival-in-patients-with-ovarian-cancer-liver-metastases"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Researchers developed and validated a nomogram to predict 1-, 2-, and 3-year overall survival (OS) in patients with ovarian cancer and liver metastases (OCLM), outperforming an external model in stability and accuracy.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/global-trends-in-ovarian-cancer-incidence-highlight-regional-histological-variations"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/91ded8cb03a23911020dad818f791a733eb5869e-5000x2813.jpg?fit=crop&auto=format" alt="Image depicting the global population | Image Credit: flashmovie - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 7th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/global-trends-in-ovarian-cancer-incidence-highlight-regional-histological-variations">Global Trends in Ovarian Cancer Incidence Highlight Regional, Histological Variations</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/global-trends-in-ovarian-cancer-incidence-highlight-regional-histological-variations"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Between 1988 and 2017, there were significant global variations and trends in ovarian cancer incidence and its subtypes, influenced by genetic, reproductive, and socioeconomic factors.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-ovarian-cancer-content-of-2024"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/365a67fb85ac0e36e5238b7fccca3f4a45a2d9f3-3187x1625.png?fit=crop&auto=format" alt="TOP 5 ovarian cancer articles of 2024 | Image Credit: Venngage" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-ovarian-cancer-content-of-2024">Top 5 Most-Read Ovarian Cancer Content of 2024</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-ovarian-cancer-content-of-2024"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The top 5 ovarian cancer articles of 2024 covered topics such as the impact of air pollution on ovarian cancer risk, treatment strategies for patients with liver metastases, and the benefits of early diagnosis through symptom-triggered testing.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/exercise-may-benefit-chemotherapy-induced-peripheral-neuropathy-in-patients-with-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ce528ffc3a9f408d3524b0394f6df6d68937baf5-4481x3347.jpg?fit=crop&auto=format" alt="Healthy lifestyle illustration | Image Credit: SkyLine - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/exercise-may-benefit-chemotherapy-induced-peripheral-neuropathy-in-patients-with-ovarian-cancer"> Exercise May Benefit Chemotherapy-Induced Peripheral Neuropathy in Patients With Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/exercise-may-benefit-chemotherapy-induced-peripheral-neuropathy-in-patients-with-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Exercise interventions may help manage chemotherapy-induced peripheral neuropathy (CIPN) in patients with ovarian cancer through improved physical activity and muscle function, but evidence remains limited. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/addressing-ovarian-cancer-outcome-disparities-with-cultural-understanding-disaggregated-research"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/13e1ec1625db5863f6d97127e5e832db51a4d56d-2880x1552.png?fit=crop&auto=format" alt="Dr Alice Lee" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/addressing-ovarian-cancer-outcome-disparities-with-cultural-understanding-disaggregated-research">Addressing Ovarian Cancer Outcome Disparities With Cultural Understanding, Disaggregated Research</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/addressing-ovarian-cancer-outcome-disparities-with-cultural-understanding-disaggregated-research"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In the final part of our interview, Alice W. Lee, PhD, MPH, highlights the importance of addressing ovarian cancer care disparities and beyond by understanding cultural and behavioral factors and adopting a more disaggregated approach to research.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/uncovering-factors-driving-survival-in-hawaiian-pacific-islander-asian-indian-pakistani-patients-with-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/13e1ec1625db5863f6d97127e5e832db51a4d56d-2880x1552.png?fit=crop&auto=format" alt="Dr Alice Lee" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/uncovering-factors-driving-survival-in-hawaiian-pacific-islander-asian-indian-pakistani-patients-with-ovarian-cancer">Uncovering Factors Driving Survival in Hawaiian/Pacific Islander, Asian Indian/Pakistani Patients With Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/uncovering-factors-driving-survival-in-hawaiian-pacific-islander-asian-indian-pakistani-patients-with-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In part 2 of our interview, Alice W. Lee, PhD, MPH, of California State University, Fullerton, examines survival disparities between Hawaiian/Pacific Islander and Asian Indian/Pakistani patients with ovarian cancer and suggests areas for further research.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/revealing-ovarian-cancer-survival-gaps-among-asian-american-subgroups"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/13e1ec1625db5863f6d97127e5e832db51a4d56d-2880x1552.png?fit=crop&auto=format" alt="Dr Alice Lee" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 11th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/revealing-ovarian-cancer-survival-gaps-among-asian-american-subgroups">Revealing Ovarian Cancer Survival Gaps Among Asian American Subgroups</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/revealing-ovarian-cancer-survival-gaps-among-asian-american-subgroups"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Alice W. Lee, PhD, MPH, of California State University, Fullerton, discusses her study on ovarian cancer survival disparities among disaggregated Asian American subgroups, emphasizing the need for a subgroup-specific approach in cancer research.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/individualized-niraparib-starter-dosing-cuts-ae-costs-in-ovarian-cancer-by-48-"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9061fa91e0f58ab9704b813e03eb84939657fc9c-7000x6000.jpg?fit=crop&auto=format" alt="3D illustration of ovarian cancer | Image Credit: Lars Neumann - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 9th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/individualized-niraparib-starter-dosing-cuts-ae-costs-in-ovarian-cancer-by-48-">Individualized Niraparib Starter Dosing Cuts AE Costs in Ovarian Cancer by 48% </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/individualized-niraparib-starter-dosing-cuts-ae-costs-in-ovarian-cancer-by-48-"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Implementing an individualized starting dose (ISD) of niraparib (Zejula; GSK) reduced severe hematologic adverse event (AE) management costs by 48% compared with a fixed starting dose (FSD) in US patients with ovarian cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/european-commission-approves-mirvetuximab-soravtansine-for-fr-platinum-resistant-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2a7e6da13cd54f8f4d50bf5103d47fe5ad2d6d36-7952x5304.jpg?fit=crop&auto=format" alt="European Commission headquarters | Image Credit: Andrzej - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 28th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/european-commission-approves-mirvetuximab-soravtansine-for-fr-platinum-resistant-ovarian-cancer">European Commission Approves Mirvetuximab Soravtansine for FRα+ Platinum-Resistant Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/caroline-seymour">Caroline Seymour</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/european-commission-approves-mirvetuximab-soravtansine-for-fr-platinum-resistant-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The European Commission has approved mirvetuximab soravtansine for select patients with pretreated folate receptor–alpha (FRα)-positive, platinum-resistant ovarian cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/27d488950c5a56c184f46ca9ccce51baadec1a29-5607x3738.jpg?fit=crop&auto=format" alt="FDA headquarters | Image Credit: Grandbrothers - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application">Avutometinib With Defactinib for Recurrent KRAS Mutant LGSOC Completes Rolling New Drug Application</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gillian-mcgovern">Gillian McGovern</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/avutometinib-with-defactinib-for-recurrent-kras-mutant-lgsoc-completes-rolling-new-drug-application"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">If approved, the combination regimen would be the first FDA-approved treatment for adults with recurrent KRAS mutant low-grade serous ovarian cancer (LGSOC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/early-palliative-care-linked-to-better-end-of-life-outcomes-in-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/10079312e506a633cf4fcc09d893a56878bf8769-3407x2272.jpg?fit=crop&auto=format" alt="Palliative care | Image Credit: Chinnapong - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/early-palliative-care-linked-to-better-end-of-life-outcomes-in-ovarian-cancer">Early Palliative Care Linked to Better End-of-Life Outcomes in Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/early-palliative-care-linked-to-better-end-of-life-outcomes-in-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Initiating palliative care more than 3 months before death improves end-of-life outcomes for patients with ovarian cancer, highlighting the need for earlier interventions.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/ovarian-cancer-survival-varies-widely-among-asian-american-subgroups"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6f2fc8a9e7a252b4baa794ee22a2366320113ddc-4875x3254.jpg?fit=crop&auto=format" alt="Female Asian patient at doctor | Image Credit: DragonImages - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/ovarian-cancer-survival-varies-widely-among-asian-american-subgroups">Ovarian Cancer Survival Varies Widely Among Asian American Subgroups</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/ovarian-cancer-survival-varies-widely-among-asian-american-subgroups"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Researchers found significant differences in ovarian cancer survival among Asian American subgroups, emphasizing the importance of analyzing these groups separately.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/hpv-16-and-18-linked-to-ovarian-cancer-risk"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/de86d9810f29d894a160698aa1f04cff5ef864b5-4496x2998.jpg?fit=crop&auto=format" alt="HPV written in blocks | Image Credit: Iana Alter - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/hpv-16-and-18-linked-to-ovarian-cancer-risk">HPV 16 and 18 Linked to Ovarian Cancer Risk</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/celeste-krewson">Celeste Krewson</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/hpv-16-and-18-linked-to-ovarian-cancer-risk"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In a recent meta-analysis, the prevalence of human papillomavirus (HPV), especially types 16 and 18, was significantly increased among patients with ovarian cancer (OC) vs controls.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/prediagnosis-diet-improves-survival-in-black-women-with-deadly-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/95ae94b6929d8af813dcc28387af844f6495d93c-6000x4000.jpg?fit=crop&auto=format" alt="Balanced diet | Image Credit: nadianb - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/prediagnosis-diet-improves-survival-in-black-women-with-deadly-ovarian-cancer">Prediagnosis Diet Improves Survival in Black Women With Deadly Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/prediagnosis-diet-improves-survival-in-black-women-with-deadly-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Moderate prediagnosis adherence to dietary guidelines was associated with improved survival rates among Black women with high-grade serous ovarian cancer, the most common and lethal type of ovarian cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/neoadjuvant-chemotherapy-becomes-leading-initial-treatment-for-advanced-epithelial-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/5215a9b6df28ab95e4de190587970b47a6927095-8185x3936.jpg?fit=crop&auto=format" alt="Patient with ovarian cancer | Image Credit: Kiattisak - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/neoadjuvant-chemotherapy-becomes-leading-initial-treatment-for-advanced-epithelial-ovarian-cancer">Neoadjuvant Chemotherapy Becomes Leading Initial Treatment for Advanced Epithelial Ovarian Cancer </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/neoadjuvant-chemotherapy-becomes-leading-initial-treatment-for-advanced-epithelial-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">By 2021, neoadjuvant chemotherapy followed by interval cytoreductive surgery became the most common initial treatment for patients with advanced epithelial ovarian cancer, overtaking primary cytoreductive surgery.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/increased-ovarian-cancer-risk-linked-to-elevated-nitrogen-dioxide-exposure-study-finds"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/85852efeae284c814aaa87aaadbccc2183c0ab37-2600x1733.jpg?fit=crop&auto=format" alt="Air pollution | Image Credit: hramovnick - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/increased-ovarian-cancer-risk-linked-to-elevated-nitrogen-dioxide-exposure-study-finds">Increased Ovarian Cancer Risk Linked to Elevated Nitrogen Dioxide Exposure, Study Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/increased-ovarian-cancer-risk-linked-to-elevated-nitrogen-dioxide-exposure-study-finds"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Higher levels of ambient nitrogen dioxide may be linked to an increased incidence of ovarian cancer, while associations with other pollutants remain inconclusive.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/mirvetuximab-soravtansine-effective-in-patients-with-fr-platinum-sensitive-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/07297585bd1fa6181311a0dc2828096ac827fadb-6000x4000.jpg?fit=crop&auto=format" alt="3D ovarian cancer illustration | Image Credit: Dr_Microbe - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/mirvetuximab-soravtansine-effective-in-patients-with-fr-platinum-sensitive-ovarian-cancer">Mirvetuximab Soravtansine Effective in Patients With FRα+, Platinum-Sensitive Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/mirvetuximab-soravtansine-effective-in-patients-with-fr-platinum-sensitive-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The phase 2 PICCOLO trial demonstrated that mirvetuximab soravtansine (Elahere; AbbVie) is effective and tolerable in heavily pre-treated patients with folate receptor alpha-positive (FRα+), platinum-sensitive ovarian cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/high-alternate-mediterranean-diet-scores-tied-to-better-survival-in-patients-with-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/95ff982357e851e86816466724299ef212f58a20-7000x5250.jpg?fit=crop&auto=format" alt="Mediterranean diet | Image Credit: fascinadora - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 4th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/high-alternate-mediterranean-diet-scores-tied-to-better-survival-in-patients-with-ovarian-cancer">High Alternate Mediterranean Diet Scores Tied to Better Survival in Patients With Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/high-alternate-mediterranean-diet-scores-tied-to-better-survival-in-patients-with-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Higher pre- and postdiagnosis Alternate Mediterranean Diet (AMED) scores are associated with improved overall survival in patients with ovarian cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/ovarian-cancer-awareness-month-prioritizing-early-detection-bridging-equity-gaps"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/0fdf8b60d36502346dad640d968b240abb6a107e-5123x2928.jpg?fit=crop&auto=format" alt="National Ovarian Cancer Awareness Month | Image Credit: Rabin - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/ovarian-cancer-awareness-month-prioritizing-early-detection-bridging-equity-gaps">Ovarian Cancer Awareness Month: Prioritizing Early Detection, Bridging Equity Gaps</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/ovarian-cancer-awareness-month-prioritizing-early-detection-bridging-equity-gaps"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">September marked Ovarian Cancer Awareness Month, highlighting the importance of early detection and the need for equitable treatment access.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/5-things-to-know-about-low-grade-serous-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a767af953b34b0714628e821b0b22bf5543b8087-5204x3469.jpg?fit=crop&auto=format" alt="Ovarian cancer awareness ribbon | Image credit: SewcreamStudio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/5-things-to-know-about-low-grade-serous-ovarian-cancer">5 Things to Know About Low-Grade Serous Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/5-things-to-know-about-low-grade-serous-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The first-ever Low-Grade Serous Ovarian Cancer (LGSOC) Awareness Day is dedicated to raising awareness, providing resources, and advocating for more research into this rare and recurrent form of ovarian cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nxp800-gains-fda-orphan-drug-status-in-arid1a-deficient-ovarian-cancers"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e5c3b74160b66d0f5dc4a49c43067efffada497d-6000x4000.jpg?fit=crop&auto=format" alt="FDA office building | Image Credit: JHVEPhoto - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nxp800-gains-fda-orphan-drug-status-in-arid1a-deficient-ovarian-cancers">NXP800 Gains FDA Orphan Drug Status in ARID1a-Deficient Ovarian Cancers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jordyn-sava">Jordyn Sava</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nxp800-gains-fda-orphan-drug-status-in-arid1a-deficient-ovarian-cancers"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">NXP800 was granted orphan drug designation from the FDA in ARID1a-deficient ovarian, fallopian tube, and primary peritoneal cancers.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/chmp-recommends-mirvetuximab-soravtansine-for-fr-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/800a7f3626117d1e471f1d66d87bd7091a407077-6000x6000.jpg?fit=crop&auto=format" alt="EMA logo | Image Credit: Ricochet64 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 25th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/chmp-recommends-mirvetuximab-soravtansine-for-fr-ovarian-cancer">CHMP Recommends Mirvetuximab Soravtansine for FRα+ Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ashling-wahner">Ashling Wahner</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/chmp-recommends-mirvetuximab-soravtansine-for-fr-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The European Medicines Agency's (EMA’s) Committee for Medicinal Products for Human Use (CHMP) has recommended the marketing authorization of mirvetuximab soravtansine (Elahere; AbbVie) for folate receptor alpha–positive (FRα+), platinum-resistant epithelial ovarian cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/olaparib-cediranib-misses-survival-end-points-in-relapsed-ovarian-cancer-trial"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/30d9c16a3ae4dc1331caff4950bdfeb772fae092-7680x4320.jpg?fit=crop&auto=format" alt="Ovarian cancer animation | Image Credit: Nuchjaree - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/olaparib-cediranib-misses-survival-end-points-in-relapsed-ovarian-cancer-trial">Olaparib/Cediranib Misses Survival End Points in Relapsed Ovarian Cancer Trial</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ashley-chan">Ashley Chan</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/olaparib-cediranib-misses-survival-end-points-in-relapsed-ovarian-cancer-trial"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Treatment with maintenance olaparib/cediranib demonstrated similar survival vs olaparib alone in platinum-sensitive relapsed ovarian cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/pan-immune-inflammation-based-nomogram-predicts-os-pfs-in-epithelial-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d1312f66d05666129741dc7a1167a0670000f8bb-7000x6000.jpg?fit=crop&auto=format" alt="ovarian cancer animation | Image Credit: Lars Neumann - stock.adobe.com " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/pan-immune-inflammation-based-nomogram-predicts-os-pfs-in-epithelial-ovarian-cancer">Pan-Immune-Inflammation–Based Nomogram Predicts OS, PFS in Epithelial Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/pan-immune-inflammation-based-nomogram-predicts-os-pfs-in-epithelial-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Researchers developed a pan-immune-inflammation–based nomogram to accurately predict overall survival (OS) and progression-free survival (PFS) in patients with epithelial ovarian cancer</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-bevacizumab-significantly-improves-progression-free-survival-in-patients-with-epithelial-ovarian-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a04261458b7c1c4b2c3c97643dbedb5a3b45b2fc-10000x6600.jpg?fit=crop&auto=format" alt="3D illustration of ovarian cancer cells | Image Credit: LASZLO - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 11th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-bevacizumab-significantly-improves-progression-free-survival-in-patients-with-epithelial-ovarian-cancer">Bevacizumab Significantly Improves Progression-Free Survival in Patients With Epithelial Ovarian Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-bevacizumab-significantly-improves-progression-free-survival-in-patients-with-epithelial-ovarian-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Adding bevacizumab to the combination therapy of carboplatin and paclitaxel significantly improved progression-free survival (PFS) in patients with epithelial ovarian cancer (EOC) but not overall survival (OS).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/ovarian-cancer?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/ovarian-cancer?page=2">2</a><a class="px-4 py-2 border-y border-r " href="/compendium/ovarian-cancer?page=3">3</a><a class="px-4 py-2 border-y border-r " href="/compendium/ovarian-cancer?page=4">4</a><a class="px-4 py-2 border-y border-r " href="/compendium/ovarian-cancer?page=5">5</a><a class="px-4 py-2 border-y border-r " href="/compendium/ovarian-cancer?page=6">6</a><a class="px-4 py-2 border-y border-r" href="/compendium/ovarian-cancer?page=2">></a></div></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div class="bg-[#00598D] xl:w-[70%] w-[70%] py-12 pl-auto"><div class="xxl:w-[75%] w-[90%] 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","_key":"fb691436bc82"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"bd448af30e39","markDefs":[],"children":[{"marks":[],"text":"","_key":"51d8a5bb34c6","_type":"span"}]},{"_type":"block","style":"normal","_key":"b1778c83eb06","markDefs":[{"_key":"fed90e20b256","nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/ovarian-cancer"}],"children":[{"_type":"span","marks":[],"text":"Looking ahead, Qin discusses how health care providers can leverage the insights from her study to address racial disparities in ","_key":"0c5bf757fac8"},{"marks":["fed90e20b256"],"text":"ovarian cancer","_key":"934fce55fe84","_type":"span"},{"_type":"span","marks":[],"text":" survival. She also emphasizes the need for further research to enhance our understanding of modifiable lifestyle factors that could improve ovarian cancer survival rates.","_key":"78bd5307b01e"}]},{"children":[{"text":"","_key":"9da3bfcc6f66","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"c8e884867825","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"f4bc8aca7710"}],"_type":"block","style":"normal","_key":"9b6a9d482e91"},{"_type":"block","style":"normal","_key":"e0a99476f8d2","markDefs":[],"children":[{"marks":["strong","underline"],"text":"","_key":"38fe3c17d22b","_type":"span"}]},{"markDefs":[],"children":[{"marks":["strong"],"text":"What factors may influence adherence to dietary guidelines?","_key":"fd2222ae09c00","_type":"span"}],"_type":"block","style":"normal","_key":"10db178205b6"},{"_type":"block","style":"normal","_key":"0a3d78ee5823","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In our study, we found that participants with higher education levels were more likely to adhere closely to dietary guidelines, but our study did not specifically assess the social factors influencing adherence to dietary guidelines. ","_key":"99a7005d651b0"}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"0c5fecf20e76"}],"_type":"block","style":"normal","_key":"ea2fd161d524","markDefs":[]},{"_type":"block","style":"normal","_key":"68224a309704","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We know that maintaining a high-quality diet is often a privilege. From many other existing studies, we know that higher dietary quality has been associated with higher individual socioeconomic status and access to healthy foods, which is also relevant at the community level. ","_key":"3d10f12a17ef"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b2d497c27783"}],"_type":"block","style":"normal","_key":"ffad0e8ac00d"},{"children":[{"_type":"span","marks":[],"text":"In our study, the associations we observed between diet and ovarian cancer survival were independent of individual-level socioeconomic status because we carefully adjusted for potential confounders in the model. However, the strategies to improve dietary quality may need to target social barriers, such as affordability and access to healthy foods.","_key":"ad1103eb57b1"}],"_type":"block","style":"normal","_key":"f8764b17da66","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"793d15250149"}],"_type":"block","style":"normal","_key":"f07cce2ab4c9"},{"markDefs":[],"children":[{"marks":["strong"],"text":"How can health care providers use your findings to address racial disparities in ovarian cancer survival?","_key":"22bdf3ca44fb0","_type":"span"}],"_type":"block","style":"normal","_key":"71d2905e9dd1"},{"_type":"block","style":"normal","_key":"c7bfc39fa140","markDefs":[],"children":[{"marks":["strong"],"text":"","_key":"a08aab6c2545","_type":"span"}]},{"_key":"9938ca13bbbf","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Our findings suggest that future dietary interventions should target women with the lowest dietary quality and that even moderate adherence to dietary guidelines may be associated with improved survival after high-grade serous ovarian cancer diagnosis among Black women. What are the components of the dietary guidelines? I think I should mention that. ","_key":"d6bf4e77ff130"}],"_type":"block","style":"normal"},{"_key":"e1fa4d1c95c5","markDefs":[],"children":[{"marks":[],"text":"","_key":"ed842a4e462d","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The dietary guidelines evaluated in this study include the current dietary guidelines for Americans. So, foods recommended for higher consumption for health benefits include fruits, vegetables, grains and beans, whole grains, dairy, total protein foods, seafood and plant proteins, and a higher ratio of unsaturated to saturated fats. Foods and dietary elements to limit for better health include refined grain, sodium, added sugars, and saturated fats.","_key":"950d54942de3"}],"_type":"block","style":"normal","_key":"425da4e138bc"},{"children":[{"_type":"span","marks":[],"text":"","_key":"58caa419e372"}],"_type":"block","style":"normal","_key":"9061f0140137","markDefs":[]},{"children":[{"_type":"span","marks":["strong"],"text":"What further research is needed to expand our understanding of modifiable lifestyle factors that could improve ovarian cancer survival rates?","_key":"1d13c0e197dd0"}],"_type":"block","style":"normal","_key":"5e9834b36757","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"","_key":"f03b6af1239c"}],"_type":"block","style":"normal","_key":"7dbd38239f9d"},{"style":"normal","_key":"0780dfeb8177","markDefs":[],"children":[{"_type":"span","marks":[],"text":"First, to validate our findings, more studies on this topic are needed. Second, although we were also interested in post-diagnosis dietary quality, the potential dietary quality changes since diagnosis, and how they affect ovarian cancer survival among Black women, we cannot answer these questions from the current study design; we encourage further research for these questions. 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","_key":"01d7f4f7e9a0"},{"_key":"bc66e65ce0f8","_type":"span","marks":["03b4ea81bd41"],"text":"high-grade serous ovarian cancer"},{"_type":"span","marks":[],"text":" diagnosis.","_key":"ab6a1d1f09c9"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"50069d8a6a8d","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"37a2896c79ee"},{"style":"normal","_key":"21cd18a9c4b5","markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"This transcript has been lightly edited for clarity.","_key":"21ea68253076"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9504b8382255"}],"_type":"block","style":"normal","_key":"e1bece7ebbcd"},{"_type":"block","style":"normal","_key":"2e6034c7331e","markDefs":[],"children":[{"marks":["strong","underline"],"text":"Transcript","_key":"292fecb43b4b","_type":"span"}]},{"_type":"block","style":"normal","_key":"8d5308f06501","markDefs":[],"children":[{"text":"Could you first discuss the survival disparities among Black women with ovarian cancer and the factors contributing to their higher mortality rates?","_key":"75f449f208610","_type":"span","marks":["strong"]}]},{"_type":"block","style":"normal","_key":"90aa23240800","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The 5-year relative survival rate for ovarian cancer is 51% overall. For Black women, it is 42%, which is lower than for other racial and ethnic groups. The causes of this survival disparity are likely multilevel and multifactorial, including socioeconomic factors, adherence to treatment guidelines, lifestyle factors, comorbid conditions, and more. ","_key":"2916473f09820"}]},{"style":"normal","_key":"2f4dde532e50","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f85d335e2f5c"}],"_type":"block"},{"_key":"64f851eb1de5","markDefs":[{"href":"https://aaces.emory.edu/","_key":"ba0e43272d2c","nofollow":true,"blank":true,"_type":"link"}],"children":[{"_type":"span","marks":[],"text":"However, we don't know much yet about multilevel factors affecting ovarian cancer survival among Black women, which really motivates the African American Cancer Epidemiology Study, ","_key":"cf099c6fe92e"},{"text":"AACES","_key":"e38180073497","_type":"span","marks":["ba0e43272d2c"]},{"_type":"span","marks":[],"text":". AACES is a multisite, population-based study aimed at better understanding the causes and survival of ovarian cancer among African American and Black women in the US. ","_key":"2d2432bc92c7"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"32ff08f329bc"}],"_type":"block","style":"normal","_key":"77967146e5ad"},{"children":[{"_type":"span","marks":[],"text":"The study's contact PI [principal investigator] is Dr Joellen Schildkraut at Emory University, and it includes many talented, dedicated researchers. This current work is based on data collected from AACES.","_key":"401dedd94f76"}],"_type":"block","style":"normal","_key":"2f5a26c51396","markDefs":[]},{"children":[{"text":"","_key":"abc5f4b9c59f","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"d85fb92de63b","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Next, could you summarize the objective of your study? What inspired you to investigate this topic?","_key":"35bcf45bfd860"}],"_type":"block","style":"normal","_key":"2566a1193c38"},{"_key":"0aec4cff7106","markDefs":[],"children":[{"text":"","_key":"89c39b92f91e","_type":"span","marks":["strong"]}],"_type":"block","style":"normal"},{"style":"normal","_key":"292471a1559f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The objective of this study is to examine associations between prediagnosis dietary patterns and survival among Black women diagnosed with epithelial ovarian cancer. As we just talked about, ovarian cancer survival among Black women is the lowest across all racial and ethnic groups. Therefore, identifying strategies, including modifiable lifestyle factors, to improve ovarian cancer survival, especially for Black women, is imperative. ","_key":"14655679d5fa0"}],"_type":"block"},{"_type":"block","style":"normal","_key":"b7cdec175005","markDefs":[],"children":[{"_key":"9fb9240ed5fa","_type":"span","marks":[],"text":""}]},{"children":[{"text":"We know poor dietary quality disproportionately affects Black populations, but its association with ovarian cancer survival among Black women remains largely unknown. This strongly motivated us to investigate this topic.","_key":"0b6d349cbe34","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"b7780871b9f1","markDefs":[]},{"markDefs":[],"children":[{"_key":"30f923985128","_type":"span","marks":["strong"],"text":""}],"_type":"block","style":"normal","_key":"4d76bd072fe1"},{"_type":"block","style":"normal","_key":"df6f054af633","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Based on your findings, what is the connection between prediagnosis dietary adherence and survival rates among Black women with high-grade serous ovarian cancer?","_key":"67c36f08e53c0"}]},{"style":"normal","_key":"fda51e3aeca9","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"","_key":"60c7b9862f84"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"In our study of 483 Black women diagnosed with epithelial ovarian cancer, we found no significant difference in overall mortality by diet for the full sample. 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What current or potential clinical strategies can mitigate this resistance?","_key":"7893c42ae8110"}],"_type":"block","style":"normal","_key":"4ce9b881e112"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"This is definitely a concern we have as we're moving forward in ovarian cancer treatment in the future. What we've found from current data is that patients who are most likely to benefit from PARP inhibitors are those with a pathogenic ","_key":"e507b918d0e10"},{"_type":"span","marks":["em"],"text":"BRCA","_key":"e507b918d0e11"},{"_key":"e507b918d0e12","_type":"span","marks":[],"text":" mutation or other homologous recombination deficiencies. We do know that the "},{"marks":["em"],"text":"BRCA","_key":"e507b918d0e13","_type":"span"},{"_type":"span","marks":[],"text":" reversion is a possibility that can make these patients actually less susceptible to the benefits of PARP inhibitors. As we move forward, it will be important to figure out other ways to actually overcome PARP inhibitor resistance with these different reversions.","_key":"e507b918d0e14"}],"_type":"block","style":"normal","_key":"e294043c89f9"},{"children":[{"marks":["strong"],"text":"What do you see on the horizon for PARP inhibitors in ovarian cancer treatment, whether in novel therapies/combinations or in regulatory changes?","_key":"ea52524231ef0","_type":"span"}],"_type":"block","style":"normal","_key":"572a08995aa8","markDefs":[]},{"style":"normal","_key":"a0fbd5da55b3","markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think the next steps in PARP inhibitor development include identifying additional biomarkers that may indicate which patients will benefit the most from this class of therapies. There are currently several clinical trials looking into combining PARP inhibitors with other types of therapies, such as immunotherapy or other anti-angiogenics to see if there's a synergistic effect with these combinations. It'll also be interesting to see the efficacy of PARP inhibitors used after prior PARP inhibitor use. And inevitably, there'll be more information on this topic as we start to increase PARP inhibitor use in frontline treatments.","_key":"23acffc42fc50"}],"_type":"block"},{"_key":"93a2981f3261","markDefs":[],"children":[{"_key":"fa150dbbd66d0","_type":"span","marks":["strong"],"text":"Any final thoughts?"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"6731a45422bf","markDefs":[],"children":[{"_key":"6fb3b99fdc5d0","_type":"span","marks":[],"text":"PARP inhibitors are so amazing in ovarian cancer, because we haven't had anything like this in 20 years that's actually been able to almost “cure” some types of ovarian cancers—like if a patient has a platinum response and then she gets put on a PARP inhibitor with these "},{"_key":"6fb3b99fdc5d1","_type":"span","marks":["em"],"text":"BRCA "},{"marks":[],"text":"mutations. They're on it for like 2 years, and then some of them don't recur. And that's unheard of in our field before, so it's a very exciting time for us.","_key":"6fb3b99fdc5d2","_type":"span"}]}],"link":"/view/dr-whitney-goldsberry-on-the-future-of-parp-inhibitors"},{"taxonomyMapping":[{"parent":{"_ref":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","_type":"reference"},"perKeywordMapping":["Gynecologic Cancer","Health Equity Diversity \u0026 Inclusion"],"name":"Ovarian Cancer","identifier":"ovarian-cancer","_createdAt":"2020-11-06T18:46:32Z","_rev":"lr42ZkL95YwmOo7eXMlKXl","_type":"taxonomy","_id":"6a2edd2a-0a01-4a76-a275-5e9152ffa52c","_updatedAt":"2023-11-03T18:14:23Z","cmeType":"per"}],"_updatedAt":"2021-02-05T22:51:12Z","body":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e837081b5b63"}],"_type":"block","style":"normal","_key":"8e394e13335e"},{"_type":"video","videoID":"6229608129001","source":"brightcove","_key":"f6587b60914c"},{"children":[{"text":"Whitney Goldsberry, MD, a fellow at the University of Alabama's Division of Gynecologic Oncology in the Department of Obstetrics and Gynecology, discusses findings from her and colleagues' ","_key":"f1a72da30398","_type":"span","marks":[]},{"_type":"span","marks":["63ae87f21aeb"],"text":"recent analysis ","_key":"b11f0ae718f9"},{"_type":"span","marks":[],"text":"of cost-sharing trends for PARP inhibitors in ovarian cancer treatment. ","_key":"5abf8765ef3b"}],"_type":"block","style":"normal","_key":"664a819061e7","markDefs":[{"_type":"link","href":"https://pubmed.ncbi.nlm.nih.gov/33414026/","_key":"63ae87f21aeb","blank":true}]},{"style":"normal","_key":"2b6eba2b3584","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"03db251994e0"}],"_type":"block"},{"style":"normal","_key":"94a7a1e57932","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Payers had the highest cost in your analysis, but nearly half of the patients in the study utilized financial assistance programs to gain access to PARP inhibitors. What does this say in terms of co-pays being a potential financial barrier to these therapies?","_key":"28b9c6a79daa"}],"_type":"block"},{"_type":"block","style":"normal","_key":"f5007dd5510a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Fortunately, we found that patient out-of-pocket costs were actually generally low. About 75% of patients paid less than $5 a month for their prescriptions. And there were outliers—there was one patient in our study who paid over $3,000 for just a one-month supply. Therefore, in the ability of patients to access [these drugs], co-pays could be a potential financial barrier. To aid in that, we utilize specialty pharmacists who actually assist in obtaining financial assistance for patients, which could include things like co-pay assistance, or sometimes even a free drug from different manufacturers.","_key":"febe85a1af06"}]},{"markDefs":[],"children":[{"text":"PARP inhibitors have seen several new indications since they were first approved for ovarian cancer treatment in 2014. What trends did you see in cost over time?","_key":"a3cfabe63c5c","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"0b67593cf7ff"},{"_type":"block","style":"normal","_key":"8a7c2afd0cca","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Although our study was limited by a small number, we didn't note a few general patterns. The overall monthly cost of PARP inhibitors appeared to actually decrease from 2017 to 2019. Similarly, the monthly costs covered by payers appeared to decrease slightly, reflecting a decrease in the overall cost. Through this, thankfully, the out-of-pocket cost actually remained very low. We did notice that the contribution of financial assistance programs did increase over time, which may reflect improved utilization of existing financial assistance programs. These trends will be very important as we move forward in the broader applications of these drugs.","_key":"ee82eec217f2"}]}],"title":"Dr Whitney Goldsberry on Cost-Sharing Trends in PARP Inhibitors for Ovarian 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They're approved in 4 tumor types—breast, there are 2 of them; pancreatic; and then in prostate, there are also 2 of them. And in those breast, pancreatic and prostate, there are molecularly defined populations. I'd like to talk to you about the ovarian cancer indications. ","_key":"9199b14e722f"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"We have 9 PARP inhibitor indications in ovarian cancer. I can kind of put them into groups. The first PARP approved in treatment, that first group, was called olaparib in December of 2014. So we've been sort of using PARP inhibitors in the clinic for 6 years. And olaparib was an accelerated approval, as were the others: rucaparib, and also niraparib. And again, in the treatment setting of later lines of therapy. They're all molecularly defined populations. 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Monk, MD, FACOG, FACS, professor at the University of Arizona and Creighton University in Phoenix and clinician at Arizona Oncology, discusses the ovarian cancer patients most likely to respond well to PARP inhibition.","_key":"d84f90121493"}]},{"markDefs":[],"children":[{"text":"Transcript","_key":"b2c84a1a89dc","_type":"span","marks":["strong","underline"]}],"_type":"block","style":"normal","_key":"c372175c7ea9"},{"_key":"8ef494f6652b","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"In your experience, who are the patients who fare best with PARP inhibitors for ovarian cancer?","_key":"2edaee2a318d"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The first randomized trials to show efficacy of PARP inhibitors were these 3 maintenance treatments in recurrent ovarian cancer, and olaparib has 2 studies, Study 19 and SOLO2; niraparib of has one, NOVA; and then rucaparib has 1, ARIEL3. And so you can now use PARP inhibitors in treatment in recurrent ovarian cancer based on level 1 randomized trial data, if the patient responds to platinum, across all biomarker subgroups, because response to platinum in the recurrent setting is the biomarker. So again, if you treat a patient in platinum-sensitive relapse with carboplatin-paclitaxel, or carboplatin-liposomal doxorubicin, or even carboplatin-gemcitabine, if she responds, you can keep her in response with either olaparib, rucaparib, or niraparib without sort of ruining the patient experience. All of those studies have no decrement in patient reported outcomes, and no new safety signals identified.","_key":"ba024c0b660c"}],"_type":"block","style":"normal","_key":"d9f76edb084a"}],"contentCategory":{"name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory"},"updatedOn":null,"source":null,"factCheckAuthorMapping":null,"url":{"current":"dr-bradley-monk-on-response-to-parp-inhibitors-in-ovarian-cancer","_type":"slug"},"_updatedAt":"2021-01-01T01:15:47Z","seoTag":["PARP inhibitors","olaparib","ovarian cancer"],"published":"2020-12-28T15:00:00.000Z","_id":"dfd33a5f-46ae-4392-ac43-ed4fd80e624a","_type":"article","taxonomyMapping":[{"perKeywordMapping":["Gynecologic Cancer","Health Equity Diversity \u0026 Inclusion"],"name":"Ovarian 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developments in the regulatory landscape of PARP inhibitors since they were first approved in ovarian cancer in 2014?","_key":"d12acdda0cab","_type":"span"}],"_type":"block","style":"normal","_key":"65fa3390e22e"},{"_type":"block","style":"normal","_key":"ccc9fa7dd257","markDefs":[],"children":[{"text":"The most recent advancement in PARP inhibitors has been the use of PARP inhibitors in frontline, newly diagnosed advanced ovarian cancer. The first really amazing study was SOLO1, published in the ","_key":"7ee5c0d6b32d","_type":"span","marks":[]},{"marks":["em"],"text":"New England Journal of Medicine","_key":"22dbc9827cb1","_type":"span"},{"_type":"span","marks":[],"text":". The first author, of course, is Kathleen Moore. And that showed in maintenance frontline—again, now in the molecularly defined population of BRCA only—had a dramatic improvement in progression-free survival. And we're hoping that someday, frontline, PARP inhibition in newly diagnosed advanced ovarian cancer in BRCA patients will improve overall survival. ","_key":"53880327b53a"}]},{"markDefs":[],"children":[{"_key":"b00cf18680ab","_type":"span","marks":[],"text":"SOLO1 was a practice-changing, licensing enabling, reimbursement sort of definitive trial, but only in patients with BRCA-mutated, newly diagnosed advanced ovarian cancer that responded to chemotherapy. The challenge, though, was it was in a very well-defined but small patient population, those that had somatic or germline BRCA mutations. So somatic mutations, tumor tests, maybe 5%-10%; in germline, maybe 15%-20%. So it was only about a quarter of the patients. So then what happened is we launched this international collaboration to go beyond BRCA-mutated patients. And there is a molecular signature that I've sort of alluded to, homologous recombination repair deficiency [HRD], which can be ordered either through Foundation Medicine or through Myriad, which identifies BRCA-like genes where there might be a broader opportunity for PARP inhibition. "}],"_type":"block","style":"normal","_key":"d89e9e33a8f4"},{"children":[{"_type":"span","marks":[],"text":"We launched that study collaborating with the GOG in the European Network, and we showed that we could utilize PARP inhibitors beyond BRCA, this time niraparib in a study called PRIMA published in the ","_key":"cf37871858cb"},{"marks":["em"],"text":"New England Journal of Medicine","_key":"b86bb190b621","_type":"span"},{"_type":"span","marks":[],"text":" in December of 2019. [It was] FDA approved on April 29, 2020, beyond BRCA.In fact, it works so well that the FDA said not only can you use it in BRCA, but BRCA-like genes, and HRD. You can use it in all comers. And the study personalized the dose, and niraparib is the only once-daily PARP inhibitor, so a very distinguishing quality. 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That will sort of depend on your scenario. It could include a physician's assistant or a nurse practitioner, patient navigator, or even a pharmacist. But together, monitoring is important. We monitor the blood counts once a week generally, especially in niraparib if the platelet count begins to fall less than 100, we stop and recover. We also monitor for GI disturbances, and certainly fatigue. GI disturbances are something that you're very familiar with, you can sort of mitigate the nausea or the diarrhea. But if your land subpoena ondansetron or imodium is not working, you should stop, and recover, and then dose reduce. Fatigue is a little bit more complicated because fatigue can be due to lots of things—sleep deprivation, depression, malnutrition, dehydration, hypothyroidism, and anemia. You've got to make sure that you have the attribution, the cause of the fatigue, right before you treat it. So we have an algorithm that can inform that. But I think you have to have an understanding of monitoring the adverse reactions and the mitigation strategies of these very active, particularly in the molecularly defined subsets, oral anti-cancer therapies.","_key":"09b5c676203c"}],"_type":"block","style":"normal","_key":"b0355fd6700c"},{"children":[{"_type":"span","marks":[],"text":"","_key":"fd2f79ce7b72"}],"_type":"block","style":"normal","_key":"71afc60faae1","markDefs":[]}],"source":null,"_createdAt":"2020-12-24T02:00:18Z","contentCategory":{"_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos"},"title":"Dr Bradley Monk on Multidisciplinary Care With PARP Inhibitors","is_visible":true,"_id":"1a6249fc-ac18-495c-aaf9-89c6ac7f9282","updatedOn":null,"url":{"current":"dr-bradley-monk-on-multidisciplanary-care-with-parp-inhibitors","_type":"slug"},"_updatedAt":"2021-01-01T01:15:37Z","_rev":"XEMMD7weYl30gMqowKGTCE","factCheckAuthorMapping":null,"published":"2020-12-24T16:00:00.000Z","summary":"Bradley Monk, MD, FACOG, FACS, clinician at Arizona Oncology, shares his experience mitigating the potential side effects of PARP inhibitors in ovarian cancer treatment. 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