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The modes of reproduction examined are biparental (bisexual," /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/114250031/Accumulation_of_mutations_in_sexual_and_asexual_populations" /> <meta property="og:title" content="Accumulation of mutations in sexual and asexual populations" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="SummaryThe accumulation of beneficial and harmful mutations in a genome is studied by using analytical methods as well as computer simulation for different modes of reproduction. The modes of reproduction examined are biparental (bisexual," /> <meta property="article:author" content="https://independent.academia.edu/WenhsiungLi" /> <meta name="description" content="SummaryThe accumulation of beneficial and harmful mutations in a genome is studied by using analytical methods as well as computer simulation for different modes of reproduction. The modes of reproduction examined are biparental (bisexual," /> <title>(PDF) Accumulation of mutations in sexual and asexual populations | Wen-hsiung Li - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/114250031/Accumulation_of_mutations_in_sexual_and_asexual_populations" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732444282000); window.Aedu.timeDifference = new Date().getTime() - 1732444282000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"SummaryThe accumulation of beneficial and harmful mutations in a genome is studied by using analytical methods as well as computer simulation for different modes of reproduction. The modes of reproduction examined are biparental (bisexual, hermaphroditic), uniparental (selfing, automictic, asexual) and mixed (partial selfing, mixture of hermaphroditism and parthenogenesis). It is shown that the rates of accumulation of both beneficial and harmful mutations with weak selection depend on the within-population variance of the number of mutant genes per genome. Analytical formulae for this variance are derived for neutral mutant genes for hermaphroditic, selfing and asexual populations; the neutral variance is largest in a selfing population and smallest in an asexual population. Directional selection reduces the population variance in most cases, whereas recombination partially restores the reduced variance. Therefore, biparental organisms accumulate beneficial mutations at the highest...","author":[{"@context":"https://schema.org","@type":"Person","name":"Wen-hsiung Li"}],"contributor":[],"dateCreated":"2024-01-30","dateModified":"2024-01-30","datePublished":"1987-01-01","headline":"Accumulation of mutations in sexual and asexual populations","inLanguage":"en","keywords":["Genetics","Reproduction","Biology","Medicine","Population","Parthenogenesis","Mutation","Female","Animals","Male","Selfing","GENETICAL","Analysis of Variance","Asexual Reproduction","Genetic Recombination"],"locationCreated":null,"publication":"Genetical Research","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Hindawi Limited"},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/114250031/Accumulation_of_mutations_in_sexual_and_asexual_populations","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F114250031%2FAccumulation_of_mutations_in_sexual_and_asexual_populations%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F114250031%2FAccumulation_of_mutations_in_sexual_and_asexual_populations%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":110997259,"identifier":"Attachment_110997259","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":114250031,"created_at":"2024-01-30T05:50:24.365-08:00","from_world_paper_id":249072010,"updated_at":"2024-01-30T06:51:37.829-08:00","_data":{"abstract":"SummaryThe accumulation of beneficial and harmful mutations in a genome is studied by using analytical methods as well as computer simulation for different modes of reproduction. The modes of reproduction examined are biparental (bisexual, hermaphroditic), uniparental (selfing, automictic, asexual) and mixed (partial selfing, mixture of hermaphroditism and parthenogenesis). It is shown that the rates of accumulation of both beneficial and harmful mutations with weak selection depend on the within-population variance of the number of mutant genes per genome. Analytical formulae for this variance are derived for neutral mutant genes for hermaphroditic, selfing and asexual populations; the neutral variance is largest in a selfing population and smallest in an asexual population. Directional selection reduces the population variance in most cases, whereas recombination partially restores the reduced variance. Therefore, biparental organisms accumulate beneficial mutations at the highest...","publisher":"Hindawi Limited","publication_date":"1987,,","publication_name":"Genetical Research"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Accumulation of mutations in sexual and asexual populations","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [34594348]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":110997259,"attachmentType":"pdf"}"><img alt="First page of “Accumulation of mutations in sexual and asexual populations”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/110997259/mini_magick20240130-1-cpnbe4.png?1706624683" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Accumulation of mutations in sexual and asexual populations</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="34594348" href="https://independent.academia.edu/WenhsiungLi"><img alt="Profile image of Wen-hsiung Li" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Wen-hsiung Li</a></div><p class="ds-work-card--detail ds2-5-body-sm">1987, Genetical Research</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">SummaryThe accumulation of beneficial and harmful mutations in a genome is studied by using analytical methods as well as computer simulation for different modes of reproduction. The modes of reproduction examined are biparental (bisexual, hermaphroditic), uniparental (selfing, automictic, asexual) and mixed (partial selfing, mixture of hermaphroditism and parthenogenesis). It is shown that the rates of accumulation of both beneficial and harmful mutations with weak selection depend on the within-population variance of the number of mutant genes per genome. Analytical formulae for this variance are derived for neutral mutant genes for hermaphroditic, selfing and asexual populations; the neutral variance is largest in a selfing population and smallest in an asexual population. Directional selection reduces the population variance in most cases, whereas recombination partially restores the reduced variance. Therefore, biparental organisms accumulate beneficial mutations at the highest...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":110997259,"attachmentType":"pdf","workUrl":"https://www.academia.edu/114250031/Accumulation_of_mutations_in_sexual_and_asexual_populations"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":110997259,"attachmentType":"pdf","workUrl":"https://www.academia.edu/114250031/Accumulation_of_mutations_in_sexual_and_asexual_populations"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="110997259" data-landing_url="https://www.academia.edu/114250031/Accumulation_of_mutations_in_sexual_and_asexual_populations" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="94012927" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/94012927/The_Evolution_of_Mutation_Rate_in_Finite_Asexual_Populations">The Evolution of Mutation Rate in Finite Asexual Populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="251526311" href="https://independent.academia.edu/JeanBaptisteAndr%C3%A92">Jean-Baptiste André</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Genetics, 2005</p><p class="ds-related-work--abstract ds2-5-body-sm">In this article, we model analytically the evolution of mutation rate in asexual organisms. Three selective forces are present. First, everything else being equal, individuals with higher mutation rate have a larger fitness, thanks to the energy and time saved by not replicating DNA accurately. Second, as a flip side, the genome of these individuals is replicated with errors that may negatively affect fitness. Third, and conversely, replication errors have a potential benefit if beneficial mutations are to be generated. Our model describes the fate of modifiers of mutation rate under the three forces and allows us to predict the long-term evolutionary trajectory of mutation rate. We obtain three major results. First, in asexuals, the needs for both adaptation and genome preservation are not evolutionary forces that can stabilize mutation rate at an intermediate optimum. When adaptation has a significant role, it primarily destabilizes mutation rate and yields the emergence of strong...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Evolution of Mutation Rate in Finite Asexual Populations","attachmentId":96590680,"attachmentType":"pdf","work_url":"https://www.academia.edu/94012927/The_Evolution_of_Mutation_Rate_in_Finite_Asexual_Populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/94012927/The_Evolution_of_Mutation_Rate_in_Finite_Asexual_Populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="17478895" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17478895/Diminishing_Returns_from_Mutation_Supply_Rate_in_Asexual_Populations">Diminishing Returns from Mutation Supply Rate in Asexual Populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37236119" href="https://independent.academia.edu/BlanchardJeffrey">Jeffrey Blanchard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Science, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Diminishing Returns from Mutation Supply Rate in Asexual Populations","attachmentId":39533030,"attachmentType":"pdf","work_url":"https://www.academia.edu/17478895/Diminishing_Returns_from_Mutation_Supply_Rate_in_Asexual_Populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17478895/Diminishing_Returns_from_Mutation_Supply_Rate_in_Asexual_Populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="29468883" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/29468883/The_effect_of_the_reproductive_system_on_mutation_load">The effect of the reproductive system on mutation load</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33935606" href="https://universityofarizona.academia.edu/RichardEMichod">Richard E Michod</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Theoretical Population Biology - THEOR POP BIOL, 1988</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The effect of the reproductive system on mutation load","attachmentId":49910815,"attachmentType":"pdf","work_url":"https://www.academia.edu/29468883/The_effect_of_the_reproductive_system_on_mutation_load","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/29468883/The_effect_of_the_reproductive_system_on_mutation_load"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="74728995" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74728995/Distribution_of_fixed_beneficial_mutations_and_the_rate_of_adaptation_in_asexual_populations">Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="194511207" href="https://independent.academia.edu/IgorRouzine">Igor Rouzine</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Proceedings of the National Academy of Sciences, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">When large asexual populations adapt, competition between simultaneously segregating mutations slows the rate of adaptation and restricts the set of mutations that eventually fix. This phenomenon of interference arises from competition between mutations of different strengths as well as competition between mutations that arise on different fitness backgrounds. Previous work has explored each of these effects in isolation, but the way they combine to influence the dynamics of adaptation remains largely unknown. Here, we describe a theoretical model to treat both aspects of interference in large populations. We calculate the rate of adaptation and the distribution of fixed mutational effects accumulated by the population. We focus particular attention on the case when the effects of beneficial mutations are exponentially distributed, as well as on a more general class of exponential-like distributions. In both cases, we show that the rate of adaptation and the influence of genetic bac...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations","attachmentId":82774193,"attachmentType":"pdf","work_url":"https://www.academia.edu/74728995/Distribution_of_fixed_beneficial_mutations_and_the_rate_of_adaptation_in_asexual_populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74728995/Distribution_of_fixed_beneficial_mutations_and_the_rate_of_adaptation_in_asexual_populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="74156533" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74156533/Beneficial_mutations_and_the_dynamics_of_adaptation_in_asexual_populations">Beneficial mutations and the dynamics of adaptation in asexual populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50566687" href="https://independent.academia.edu/PGerrish">Philip Gerrish</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Philosophical Transactions of the Royal Society B: Biological Sciences, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">We discuss the dynamics of adaptive evolution in asexual (clonal) populations. The classical ‘periodic selection’ model of clonal evolution assumed that beneficial mutations are very rare and therefore substitute unfettered into populations as occasional, isolated events. Newer models allow for the possibility that beneficial mutations are sufficiently common to coexist and compete for fixation within populations. Experimental evolution studies in microbes provide empirical support for stochastic models in which both selection and mutation are strong effects and clones compete for fixation; however, the relative importance of competition among clones bearing mutations of different selective effects versus competition among clones bearing multiple mutations remains unresolved. We provide some new theoretical results, moreover, suggesting that population dynamics consistent with the periodic selection model can arise even in a deterministic model that can accommodate a very high benef...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Beneficial mutations and the dynamics of adaptation in asexual populations","attachmentId":83655782,"attachmentType":"pdf","work_url":"https://www.academia.edu/74156533/Beneficial_mutations_and_the_dynamics_of_adaptation_in_asexual_populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74156533/Beneficial_mutations_and_the_dynamics_of_adaptation_in_asexual_populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="74156501" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74156501/The_fate_of_competing_beneficial_mutations_in_an_asexual_population">The fate of competing beneficial mutations in an asexual population</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50566687" href="https://independent.academia.edu/PGerrish">Philip Gerrish</a></div><p class="ds-related-work--metadata ds2-5-body-xs">1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The fate of competing beneficial mutations in an asexual population","attachmentId":83654715,"attachmentType":"pdf","work_url":"https://www.academia.edu/74156501/The_fate_of_competing_beneficial_mutations_in_an_asexual_population","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74156501/The_fate_of_competing_beneficial_mutations_in_an_asexual_population"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="26891598" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26891598/Sex_and_Deleterious_Mutations">Sex and Deleterious Mutations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50895848" href="https://gulbenkian.academia.edu/IGordo">Isabel Gordo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Genetics, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Sex and Deleterious Mutations","attachmentId":47156002,"attachmentType":"pdf","work_url":"https://www.academia.edu/26891598/Sex_and_Deleterious_Mutations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26891598/Sex_and_Deleterious_Mutations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="85169247" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/85169247/The_population_genetics_of_mutations_good_bad_and_indifferent">The population genetics of mutations: good, bad and indifferent</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="127986434" href="https://wisc.academia.edu/LaurenceLoewe">Laurence Loewe</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Philosophical Transactions of the Royal Society B: Biological Sciences, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Population genetics is fundamental to our understanding of evolution, and mutations are essential raw materials for evolution. In this introduction to more detailed papers that follow, we aim to provide an oversight of the field. We review current knowledge on mutation rates and their harmful and beneficial effects on fitness and then consider theories that predict the fate of individual mutations or the consequences of mutation accumulation for quantitative traits. Many advances in the past built on models that treat the evolution of mutations at each DNA site independently, neglecting linkage of sites on chromosomes and interactions of effects between sites (epistasis). We review work that addresses these limitations, to predict how mutations interfere with each other. An understanding of the population genetics of mutations of individual loci and of traits affected by many loci helps in addressing many fundamental and applied questions: for example, how do organisms adapt to chan...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The population genetics of mutations: good, bad and indifferent","attachmentId":89951463,"attachmentType":"pdf","work_url":"https://www.academia.edu/85169247/The_population_genetics_of_mutations_good_bad_and_indifferent","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" 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data-collection-position="9" data-entity-id="13440514" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13440514/Mutational_Meltdowns_in_Sexual_Populations">Mutational Meltdowns in Sexual Populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32663232" href="https://univie.academia.edu/ReinhardB%C3%BCrger">Reinhard Bürger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Evolution, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mutational Meltdowns in Sexual Populations","attachmentId":45340415,"attachmentType":"pdf","work_url":"https://www.academia.edu/13440514/Mutational_Meltdowns_in_Sexual_Populations","alternativeTracking":true}"><span 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Holsinger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Proceedings of the National …, 1983</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Modifiers of mutation rate: Evolutionary optimum with complete selfing","attachmentId":5691440,"attachmentType":"pdf","work_url":"https://www.academia.edu/933563/Modifiers_of_mutation_rate_Evolutionary_optimum_with_complete_selfing","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/933563/Modifiers_of_mutation_rate_Evolutionary_optimum_with_complete_selfing"><span class="ds2-5-text-link__content">View PDF</span><span 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href="https://www.academia.edu/122635992/Limitations_of_the_inference_of_the_distribution_of_fitness_effects_of_new_mutations_in_partially_selfing_populations_with_linkage"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="10392343" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/10392343/Mutator_dynamics_in_sexual_and_asexual_experimental_populations_of_yeast">Mutator dynamics in sexual and asexual experimental populations of yeast</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="25552300" href="https://upenn.academia.edu/MatthewGazzara">Matthew Gazzara</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BMC Evolutionary Biology, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mutator dynamics in sexual and asexual experimental populations of yeast","attachmentId":47414981,"attachmentType":"pdf","work_url":"https://www.academia.edu/10392343/Mutator_dynamics_in_sexual_and_asexual_experimental_populations_of_yeast","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/10392343/Mutator_dynamics_in_sexual_and_asexual_experimental_populations_of_yeast"><span class="ds2-5-text-link__content">View PDF</span><span 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data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Using Numerical Simulation to Test the “Mutation-Count” Hypothesis","attachmentId":108281564,"attachmentType":"pdf","work_url":"https://www.academia.edu/110475909/Using_Numerical_Simulation_to_Test_the_Mutation_Count_Hypothesis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/110475909/Using_Numerical_Simulation_to_Test_the_Mutation_Count_Hypothesis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="90341127" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90341127/Fixation_of_Mutators_in_Asexual_Populations_The_Role_of_Genetic_Drift_and_Epistasis">Fixation of Mutators in Asexual Populations: The Role of Genetic Drift and Epistasis</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="236537127" href="https://independent.academia.edu/ApoorvaNagar">Apoorva Nagar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Evolution, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Fixation of Mutators in Asexual Populations: The Role of Genetic Drift and 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ds2-5-body-link" href="https://www.academia.edu/31625249/The_Fixation_Probability_of_Rare_Mutators_in_Finite_Asexual_Populations">The Fixation Probability of Rare Mutators in Finite Asexual Populations</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32605520" href="https://independent.academia.edu/DavidKessler3">David S Kessler</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Genetics, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Fixation Probability of Rare Mutators in Finite Asexual Populations","attachmentId":51950472,"attachmentType":"pdf","work_url":"https://www.academia.edu/31625249/The_Fixation_Probability_of_Rare_Mutators_in_Finite_Asexual_Populations","alternativeTracking":true}"><span class="material-symbols-outlined" 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data-author-id="54239503" href="https://independent.academia.edu/GilRoberts1">Gilbert Roberts</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Heredity, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Sexual selection and the evolution of evolvability","attachmentId":66848567,"attachmentType":"pdf","work_url":"https://www.academia.edu/48019831/Sexual_selection_and_the_evolution_of_evolvability","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/48019831/Sexual_selection_and_the_evolution_of_evolvability"><span class="ds2-5-text-link__content">View PDF</span><span 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class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Spatial structure inhibits the rate of invasion of beneficial mutations in asexual populations","attachmentId":46088643,"attachmentType":"pdf","work_url":"https://www.academia.edu/12558887/Spatial_structure_inhibits_the_rate_of_invasion_of_beneficial_mutations_in_asexual_populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/12558887/Spatial_structure_inhibits_the_rate_of_invasion_of_beneficial_mutations_in_asexual_populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" 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Stephen (Steve) Howard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The maintenance of sex by parasitism and mutation accumulation under epistatic fitness functions","attachmentId":30714360,"attachmentType":"pdf","work_url":"https://www.academia.edu/2738664/The_maintenance_of_sex_by_parasitism_and_mutation_accumulation_under_epistatic_fitness_functions","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/2738664/The_maintenance_of_sex_by_parasitism_and_mutation_accumulation_under_epistatic_fitness_functions"><span 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data-collection-position="20" data-entity-id="19030762" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19030762/EVOLUTIONARILY_STABLE_SEX_RATIOS_AND_MUTATION_LOAD">EVOLUTIONARILY STABLE SEX RATIOS AND MUTATION LOAD</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39193783" href="https://independent.academia.edu/SimoneImmler">Simone Immler</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Evolution, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"EVOLUTIONARILY STABLE SEX RATIOS AND MUTATION 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