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(PDF) Sex and Deleterious Mutations | Isabel Gordo - Academia.edu
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window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":26891598,"created_at":"2016-07-11T03:45:32.139-07:00","from_world_paper_id":155358270,"updated_at":"2024-11-13T02:10:04.806-08:00","_data":{"grobid_abstract":"The evolutionary advantage of sexual reproduction has been considered as one of the most pressing questions in evolutionary biology. While a pluralistic view of the evolution of sex and recombination has been suggested by some, here we take a simpler view and try to quantify the conditions under which sex can evolve given a set of minimal assumptions. Since real populations are finite and also subject to recurrent deleterious mutations, this minimal model should apply generally to all populations. We show that the maximum advantage of recombination occurs for an intermediate value of the deleterious effect of mutations. Furthermore we show that the conditions under which the biggest advantage of sex is achieved are those that produce the fastest fitness decline in the corresponding asexual population and are therefore the conditions for which Muller's ratchet has the strongest effect. We also show that the selective advantage of a modifier of the recombination rate depends on its strength. The quantification of the range of selective effects that favors recombination then leads us to suggest that, if in stressful environments the effect of deleterious mutations is enhanced, a connection between sex and stress could be expected, as it is found in several species.","publication_date":"2008,,","publication_name":"Genetics","grobid_abstract_attachment_id":"47156002"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Sex and Deleterious Mutations","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [50895848]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" 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translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Sex and Deleterious Mutations</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="50895848" href="https://gulbenkian.academia.edu/IGordo"><img alt="Profile image of Isabel Gordo" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Isabel Gordo</a></div><p class="ds-work-card--detail ds2-5-body-sm">2008, Genetics</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" 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class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="18454289" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18454289/Evolutionary_traction_the_cost_of_adaptation_and_the_evolution_of_sex">Evolutionary traction: the cost of adaptation and the evolution of sex</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8981820" href="https://stanford.academia.edu/MarcusFeldman">Marcus Feldman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Evolutionary Biology, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evolutionary traction: the cost of adaptation and the evolution of sex","attachmentId":40072262,"attachmentType":"pdf","work_url":"https://www.academia.edu/18454289/Evolutionary_traction_the_cost_of_adaptation_and_the_evolution_of_sex","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18454289/Evolutionary_traction_the_cost_of_adaptation_and_the_evolution_of_sex"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="26891594" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26891594/Adaptive_Evolution_of_Asexual_Populations_Under_Mullers_Ratchet">Adaptive Evolution of Asexual Populations Under Muller's Ratchet</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50895848" href="https://gulbenkian.academia.edu/IGordo">Isabel Gordo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Evolution, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Adaptive Evolution of Asexual Populations Under Muller's 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href="https://www.academia.edu/59536963/Mutation_Accumulation_May_Only_Be_a_Minor_Force_in_Shaping_Life_History_Traits_Even_when_Reproduction_Is_Sexual">Mutation Accumulation May Only Be a Minor Force in Shaping Life-History Traits, Even when Reproduction Is Sexual</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="45761022" href="https://independent.academia.edu/MaciejJanDa%C5%84ko">Maciej Jan Dańko</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mutation Accumulation May Only Be a Minor Force in Shaping Life-History Traits, Even when Reproduction Is Sexual","attachmentId":73408848,"attachmentType":"pdf","work_url":"https://www.academia.edu/59536963/Mutation_Accumulation_May_Only_Be_a_Minor_Force_in_Shaping_Life_History_Traits_Even_when_Reproduction_Is_Sexual","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/59536963/Mutation_Accumulation_May_Only_Be_a_Minor_Force_in_Shaping_Life_History_Traits_Even_when_Reproduction_Is_Sexual"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="24989501" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24989501/The_evolution_of_obligate_sex_the_roles_of_sexual_selection_and_recombination">The evolution of obligate sex: the roles of sexual selection and recombination</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="48172313" href="https://uci.academia.edu/MayaKleiman">Maya Kleiman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Ecology and Evolution, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">The evolution of sex is one of the greatest mysteries in evolutionary biology. An even greater mystery is the evolution of obligate sex, particularly when competing with facultative sex and not with complete asexuality. Here, we develop a stochastic simulation of an obligate allele invading a facultative population, where males are subject to sexual selection. We identify a range of parameters where sexual selection can contribute to the evolution of obligate sex: Especially when the cost of sex is low, mutation rate is high, and the facultative individuals do not reproduce sexually very often. The advantage of obligate sex becomes larger in the absence of recombination. Surprisingly, obligate sex can take over even when the population has a lower mean fitness as a result. We show that this is due to the high success of obligate males that can compensate the cost of sex.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The evolution of obligate sex: the roles of sexual selection and recombination","attachmentId":45682645,"attachmentType":"pdf","work_url":"https://www.academia.edu/24989501/The_evolution_of_obligate_sex_the_roles_of_sexual_selection_and_recombination","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/24989501/The_evolution_of_obligate_sex_the_roles_of_sexual_selection_and_recombination"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="13440514" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13440514/Mutational_Meltdowns_in_Sexual_Populations">Mutational Meltdowns in Sexual Populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32663232" href="https://univie.academia.edu/ReinhardB%C3%BCrger">Reinhard Bürger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Evolution, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mutational Meltdowns in Sexual Populations","attachmentId":45340415,"attachmentType":"pdf","work_url":"https://www.academia.edu/13440514/Mutational_Meltdowns_in_Sexual_Populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13440514/Mutational_Meltdowns_in_Sexual_Populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="48045330" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/48045330/On_the_evolutionary_advantage_of_fitness_associated_recombination">On the evolutionary advantage of fitness-associated recombination</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="46180595" href="https://independent.academia.edu/LilachHadany">Lilach Hadany</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Genetics, 2003</p><p class="ds-related-work--abstract ds2-5-body-sm">The adaptive value of recombination remains something of a puzzle. One of the basic problems is that recombination not only creates new and advantageous genetic combinations, but also breaks down existing good ones. A negative correlation between the fitness of an individual and its recombination rate would result in prolonged integrity of fitter genetic combinations while enabling less fit ones to produce new combinations. Such a correlation could be mediated by various factors, including stress responses, age, or direct DNA damage. For haploid population models, we show that an allele for such fitness-associated recombination (FAR) can spread both in asexual populations and in populations reproducing sexually at any uniform recombination rate. FAR also carries an advantage for the population as a whole, resulting in a higher average fitness at mutation-selection balance. These results are demonstrated in populations adapting to new environments as well as in well-adapted populatio...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"On the evolutionary advantage of fitness-associated recombination","attachmentId":66861038,"attachmentType":"pdf","work_url":"https://www.academia.edu/48045330/On_the_evolutionary_advantage_of_fitness_associated_recombination","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/48045330/On_the_evolutionary_advantage_of_fitness_associated_recombination"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="74156557" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74156557/Natural_selection_promotes_the_evolution_of_recombination_2_during_the_process_of_natural_selection_">Natural selection promotes the evolution of recombination 2: during the process of natural selection*</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50566687" href="https://independent.academia.edu/PGerrish">Philip Gerrish</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2021</p><p class="ds-related-work--abstract ds2-5-body-sm">The ubiquity of sex and recombination in nature has eluded unified explanation since the time of Darwin. Conditions that promote the evolution of recombination, broadly defined as any form of genetic mixing, are fairly well understood: it is favored when genomes tend to contain more selectively mismatched combinations of alleles than can be explained by chance alone. Yet, while a variety of theoretical approaches have been put forth to explain why such conditions would prevail in natural populations, each has turned out to be of limited scope and applicability. Here, we show, simply and surprisingly, that natural selection acting on standing heritable variation always creates conditions favoring the evolution of recombination, in expectation. Specifically, we find that, in expectation: 1) the mean selective advantage of recombinants is non-negative, 2) the mean selective advantage of a recombination-competent modifier is non-negative, and 3) the asymptotic frequency of a recombinati...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Natural selection promotes the evolution of recombination 2: during the process of natural selection*","attachmentId":82407889,"attachmentType":"pdf","work_url":"https://www.academia.edu/74156557/Natural_selection_promotes_the_evolution_of_recombination_2_during_the_process_of_natural_selection_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74156557/Natural_selection_promotes_the_evolution_of_recombination_2_during_the_process_of_natural_selection_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="29511324" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/29511324/The_evolutionary_role_of_recombinational_repair_and_sex">The evolutionary role of recombinational repair and sex</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33935606" href="https://universityofarizona.academia.edu/RichardEMichod">Richard E Michod</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International review of cytology, 1985</p><p class="ds-related-work--abstract ds2-5-body-sm">We have argued that sexual reproduction arose very early in the evolution of life as a way of overcoming informational damage or loss through recombinational repair. As organisms became more complex and genome information content expanded, diploidy, at first transient, became the predominant way of coping with increased vulnerability to mutation. This allowed further genome expansion. Once such expansion had occurred, however, diploidy became essentially irreversible, since reversion to haploidy would lead to expression of accumulated deleterious recessive alleles. This expression of recessive alleles also imposes a stiff penalty on organisms that experiment with close inbreeding forms of recombinational repair. A consequence of sex is that fitness (defined as per capita rate of increase) is density dependent. At low population density, fitness declines due to increased costs of finding a mate. This fundamental constraint on population increase can inhibit evolutionary success of th...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The evolutionary role of recombinational repair and sex","attachmentId":49948814,"attachmentType":"pdf","work_url":"https://www.academia.edu/29511324/The_evolutionary_role_of_recombinational_repair_and_sex","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/29511324/The_evolutionary_role_of_recombinational_repair_and_sex"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="74156553" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74156553/Natural_selection_and_the_advantage_of_recombination">Natural selection and the advantage of recombination</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50566687" href="https://independent.academia.edu/PGerrish">Philip Gerrish</a></div><p class="ds-related-work--abstract ds2-5-body-sm">The ubiquity of sex and recombination in nature is widely viewed as enigmatic, despite an abundance of limited-scope explanations. Natural selection, it seems, should amplify well-matched combinations of genes. Recombination would break up these well-matched combinations and should thus be suppressed. We show, to the contrary, that natural selection amplifies poorly-matched gene combinations and creates negative associations in the process. Recombination breaks up these poorly-matched combinations, neutralizes the negative associations, and should thus be passively and universally favored.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Natural selection and the advantage of recombination","attachmentId":82407926,"attachmentType":"pdf","work_url":"https://www.academia.edu/74156553/Natural_selection_and_the_advantage_of_recombination","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74156553/Natural_selection_and_the_advantage_of_recombination"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="48019831" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/48019831/Sexual_selection_and_the_evolution_of_evolvability">Sexual selection and the evolution of evolvability</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="54239503" href="https://independent.academia.edu/GilRoberts1">Gilbert Roberts</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Heredity, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Sexual selection and the evolution of evolvability","attachmentId":66848567,"attachmentType":"pdf","work_url":"https://www.academia.edu/48019831/Sexual_selection_and_the_evolution_of_evolvability","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/48019831/Sexual_selection_and_the_evolution_of_evolvability"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":47156002,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":47156002,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_47156002" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="18454208" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18454208/POPULATION_GENETIC_PERSPECTIVES_ON_THE_EVOLUTION_OF_RECOMBINATION">POPULATION GENETIC PERSPECTIVES ON THE EVOLUTION OF RECOMBINATION</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8981820" href="https://stanford.academia.edu/MarcusFeldman">Marcus Feldman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Annual Review of Genetics, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"POPULATION GENETIC PERSPECTIVES ON THE EVOLUTION OF 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href="https://www.academia.edu/17352107/The_red_queen_coupled_with_directional_selection_favours_the_evolution_of_sex">The red queen coupled with directional selection favours the evolution of sex</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37073031" href="https://independent.academia.edu/HodgsonEmma">Emma E Hodgson</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Evolutionary Biology, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The red queen coupled with directional selection favours the evolution of sex","attachmentId":39461598,"attachmentType":"pdf","work_url":"https://www.academia.edu/17352107/The_red_queen_coupled_with_directional_selection_favours_the_evolution_of_sex","alternativeTracking":true}"><span 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data-author-id="4639383" href="https://univ-rennes1.academia.edu/JeanS%C3%A9bastienPierre">Jean-Sébastien Pierre</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PLOS ONE, 2022</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The advantage of sex: Reinserting fluctuating selection in the pluralist approach","attachmentId":107278698,"attachmentType":"pdf","work_url":"https://www.academia.edu/109041684/The_advantage_of_sex_Reinserting_fluctuating_selection_in_the_pluralist_approach","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34111935" href="https://independent.academia.edu/SolAckerman">Sol Ackerman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Heredity, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Finite Populations, Finite Resources, and the Evolutionary Maintenance of Genetic Recombination","attachmentId":51426934,"attachmentType":"pdf","work_url":"https://www.academia.edu/390596/Finite_Populations_Finite_Resources_and_the_Evolutionary_Maintenance_of_Genetic_Recombination","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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href="https://mtsu.academia.edu/RStephenSteveHoward">R. Stephen (Steve) Howard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The maintenance of sex by parasitism and mutation accumulation under epistatic fitness functions","attachmentId":30714360,"attachmentType":"pdf","work_url":"https://www.academia.edu/2738664/The_maintenance_of_sex_by_parasitism_and_mutation_accumulation_under_epistatic_fitness_functions","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/2738664/The_maintenance_of_sex_by_parasitism_and_mutation_accumulation_under_epistatic_fitness_functions"><span 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18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="18" data-entity-id="25057233" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25057233/Evolution_of_genetic_variability_and_the_advantage_of_sex_and_recombination_in_changing_environments">Evolution of genetic variability and the advantage of sex and recombination in changing environments</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32663232" href="https://univie.academia.edu/ReinhardB%C3%BCrger">Reinhard Bürger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="19" data-entity-id="13440541" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13440541/The_Mutational_Meltdown_in_Asexual_Populations">The Mutational Meltdown in Asexual Populations</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32663232" href="https://univie.academia.edu/ReinhardB%C3%BCrger">Reinhard Bürger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Mutational Meltdown in Asexual 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href="https://www.academia.edu/74156533/Beneficial_mutations_and_the_dynamics_of_adaptation_in_asexual_populations">Beneficial mutations and the dynamics of adaptation in asexual populations</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50566687" href="https://independent.academia.edu/PGerrish">Philip Gerrish</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Philosophical Transactions of the Royal Society B: Biological Sciences, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Beneficial mutations and the dynamics of adaptation in asexual 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