CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Università degli Studi di Napoli "Federico II" | Chimica delle Sostanze Naturali - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "departments", 'action': "show_works", 'controller_action': 'departments#show_works', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="MlWrqhr5ehW1+6vd6uGjAADL0N8Z9PfvsvKcgPGFEQ0LW+xkg4vvheeiTPIiYa30AXPCep4U9FgLiPGnSOcVGg==" /> <link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="description" content="Academia.edu is the platform to share, find, and explore 50 Million research papers. Join us to accelerate your research needs & academic interests." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'departments'; var $action_name = "show_works"; var $rails_env = 'production'; var $app_rev = '0192aed340bff0301971519c3416a67fe8da52c1'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15260,"monthly_visitors":"114 million","monthly_visitor_count":114645693,"monthly_visitor_count_in_millions":114,"user_count":278061576,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1733347869000); window.Aedu.timeDifference = new Date().getTime() - 1733347869000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-bdb9e8c097f01e611f2fc5e2f1a9dc599beede975e2ae5629983543a1726e947.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-bad3fa1257b860f4633ff1db966aa3ae7dfe1980708675f3e2488742c1a0d941.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-1c1498a5b24f10d2247f356d96ae785336598a8a91e69dfad306a1225e0ddaa3.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://unina.academia.edu/Departments/Chimica_delle_Sostanze_Naturali/Documents" /> </head>   <body class='c-departments a-show_works logged_out u-bgColorWhite'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav no-xs no-sm no-md"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://medium.com/@academia">Blog</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <div class="DesignSystem" style="margin-top:-40px"><div class="PageHeader"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><div class="u-floatLeft u-fs24 u-tcGrayDarkest"><span class="PageHeader-title u-m0x u-fw700 u-mr5x u-pr5x u-borderColorGrayLight u-borderRight1"><a href="https://unina.academia.edu/"><span class="u-linkUnstyled u-tcGrayDarkest">Università degli Studi di Napoli "Federico II"</span></a></span><h1 class="u-m0x u-fw300 u-fs24 u-displayInline">Chimica delle Sostanze Naturali</h1></div><div class="u-floatRight u-mt1x"></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline"><li class="u-floatLeft u-pr5x u-mr5x u-borderColorGrayLight u-borderRight1"><a href="https://unina.academia.edu/"><span><i class="fa fa-arrow-left"></i>  All Departments</span></a></li><li class="u-floatLeft active"><a href="https://unina.academia.edu/Departments/Chimica_delle_Sostanze_Naturali/Documents">75 Papers</a></li><li class="u-floatLeft"><a href="https://unina.academia.edu/Departments/Chimica_delle_Sostanze_Naturali">5 Researchers</a></li></ul></div></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="u-ph0x"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_1212764" data-work_id="1212764" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/1212764/Synthesis_and_pharmacological_evaluation_of_potent_and_highly_selective_D3_receptor_ligands_inhibition_of_cocaine_seeking_behavior_and_the_role_of_dopamine_D3_D2_">Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 …</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/1212764" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="eea8b9cca43ec127e77c373d3f61125b" rel="nofollow" data-download="{"attachment_id":51059090,"asset_id":1212764,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51059090/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_1212764 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="1212764"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 1212764, container: ".js-paper-rank-work_1212764", }); });</script></li><li class="js-percentile-work_1212764 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 1212764; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_1212764"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_1212764 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="1212764"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 1212764; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=1212764]").text(description); $(".js-view-count-work_1212764").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_1212764").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="1212764"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="531" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2375" href="https://www.academia.edu/Documents/in/Medicinal_Chemistry">Medicinal Chemistry</a>, <script data-card-contents-for-ri="2375" type="text/json">{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6947" href="https://www.academia.edu/Documents/in/Medical_Microbiology">Medical Microbiology</a>, <script data-card-contents-for-ri="6947" type="text/json">{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="13841" href="https://www.academia.edu/Documents/in/Drug_development">Drug development</a><script data-card-contents-for-ri="13841" type="text/json">{"id":13841,"name":"Drug development","url":"https://www.academia.edu/Documents/in/Drug_development","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=1212764]'), work: {"id":1212764,"title":"Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 …","created_at":"2012-01-10T04:58:17.017-08:00","owner_id":1110486,"url":"https://www.academia.edu/1212764/Synthesis_and_pharmacological_evaluation_of_potent_and_highly_selective_D3_receptor_ligands_inhibition_of_cocaine_seeking_behavior_and_the_role_of_dopamine_D3_D2_","slug":"Synthesis_and_pharmacological_evaluation_of_potent_and_highly_selective_D3_receptor_ligands_inhibition_of_cocaine_seeking_behavior_and_the_role_of_dopamine_D3_D2_","dom_id":"work_1212764","summary":null,"publication":"Journal of medicinal …","publication_with_fallback":"Journal of medicinal …","downloadable_attachments":[{"id":51059090,"asset_id":1212764,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/51059090/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/51059090/Synthesis_and_pharmacological_evaluation20161226-18956-6vryp9-libre.pdf?1482750629=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_pharmacological_evaluation.pdf\u0026Expires=1732525151\u0026Signature=RBBtEIHzCgLYMzDZ2FkURdjhYZZsvhTB4i7ty7CTh7UpXQe4BkZ9f1aibPVJJ72NL-~yMmkJ9ZZoxaw~OIHGX0rG4rBgNL2rosFXSYkokARiBXbroVWb4csyffxvNwMql3pKFNQvPSht0oOm5C3Gg~t2lc1DnvxyTHzotrFwcW6nK-bVgDKLpv9UaHcRQbzozSxFrv8OPFMKxK~YKCliuDpfKtqJ8NQlHOAJZfjn~NdZU6G5lPdCpEBFgFk7q~yfst1W1G8ZOqxgQqTsz01EkEntVGtJFri2Y5CX1qznGNRyhlqCqlTjEErXfeFuohLOzrv40KbMzLxJrzkVaNZYJQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/51059090/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/51059090/mini_magick20190126-22423-1w41num.png?1548542807"}],"downloadable_attachments_with_full_thumbnails":[{"id":51059090,"asset_id":1212764,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/51059090/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/51059090/Synthesis_and_pharmacological_evaluation20161226-18956-6vryp9-libre.pdf?1482750629=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_pharmacological_evaluation.pdf\u0026Expires=1732525151\u0026Signature=RBBtEIHzCgLYMzDZ2FkURdjhYZZsvhTB4i7ty7CTh7UpXQe4BkZ9f1aibPVJJ72NL-~yMmkJ9ZZoxaw~OIHGX0rG4rBgNL2rosFXSYkokARiBXbroVWb4csyffxvNwMql3pKFNQvPSht0oOm5C3Gg~t2lc1DnvxyTHzotrFwcW6nK-bVgDKLpv9UaHcRQbzozSxFrv8OPFMKxK~YKCliuDpfKtqJ8NQlHOAJZfjn~NdZU6G5lPdCpEBFgFk7q~yfst1W1G8ZOqxgQqTsz01EkEntVGtJFri2Y5CX1qznGNRyhlqCqlTjEErXfeFuohLOzrv40KbMzLxJrzkVaNZYJQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/51059090/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/51059090/mini_magick20190126-22423-1w41num.png?1548542807"}],"has_pdf":true,"has_fulltext":true,"page_count":6,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false},{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry","nofollow":false},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology","nofollow":false},{"id":13841,"name":"Drug development","url":"https://www.academia.edu/Documents/in/Drug_development","nofollow":false},{"id":151951,"name":"Animal Model","url":"https://www.academia.edu/Documents/in/Animal_Model"},{"id":394778,"name":"Sodium channel","url":"https://www.academia.edu/Documents/in/Sodium_channel"},{"id":446162,"name":"Medicinal","url":"https://www.academia.edu/Documents/in/Medicinal"},{"id":728493,"name":"Bioorganic and medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Bioorganic_and_medicinal_Chemistry"},{"id":747113,"name":"Chronic Inflammation","url":"https://www.academia.edu/Documents/in/Chronic_Inflammation"},{"id":951639,"name":"Murine Model","url":"https://www.academia.edu/Documents/in/Murine_Model"}],"publication_year":2003,"publication_year_with_fallback":2003,"paper_rank":null,"all_time_views":19,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_1212765" data-work_id="1212765" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/1212765/Neuronal_high_affinity_sodium_dependent_glutamate_transporters_EAATs_targets_for_the_development_of_novel_therapeutics_against_neurodegenerative_diseases">Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/1212765" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5dda6d152ceea7ca547b5cb4a9c66ea0" rel="nofollow" data-download="{"attachment_id":7551246,"asset_id":1212765,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/7551246/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_1212765 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="1212765"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 1212765, container: ".js-paper-rank-work_1212765", }); });</script></li><li class="js-percentile-work_1212765 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 1212765; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_1212765"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_1212765 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="1212765"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 1212765; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=1212765]").text(description); $(".js-view-count-work_1212765").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_1212765").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="1212765"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">21</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2513" href="https://www.academia.edu/Documents/in/Molecular_Biology">Molecular Biology</a>, <script data-card-contents-for-ri="2513" type="text/json">{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="37848" href="https://www.academia.edu/Documents/in/Neurodegenerative_Diseases">Neurodegenerative Diseases</a>, <script data-card-contents-for-ri="37848" type="text/json">{"id":37848,"name":"Neurodegenerative Diseases","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Diseases","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="42973" href="https://www.academia.edu/Documents/in/Amyotrophic_Lateral_Sclerosis">Amyotrophic Lateral Sclerosis</a>, <script data-card-contents-for-ri="42973" type="text/json">{"id":42973,"name":"Amyotrophic Lateral Sclerosis","url":"https://www.academia.edu/Documents/in/Amyotrophic_Lateral_Sclerosis","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="61233" href="https://www.academia.edu/Documents/in/Glutamate">Glutamate</a><script data-card-contents-for-ri="61233" type="text/json">{"id":61233,"name":"Glutamate","url":"https://www.academia.edu/Documents/in/Glutamate","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=1212765]'), work: {"id":1212765,"title":"Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases","created_at":"2012-01-10T04:58:17.080-08:00","owner_id":1110486,"url":"https://www.academia.edu/1212765/Neuronal_high_affinity_sodium_dependent_glutamate_transporters_EAATs_targets_for_the_development_of_novel_therapeutics_against_neurodegenerative_diseases","slug":"Neuronal_high_affinity_sodium_dependent_glutamate_transporters_EAATs_targets_for_the_development_of_novel_therapeutics_against_neurodegenerative_diseases","dom_id":"work_1212765","summary":null,"publication":"Current …","publication_with_fallback":"Current …","downloadable_attachments":[{"id":7551246,"asset_id":1212765,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/7551246/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/7551246/eaat_review-libre.pdf?1390852038=\u0026response-content-disposition=attachment%3B+filename%3DNeuronal_high_affinity_sodium_dependent.pdf\u0026Expires=1733320512\u0026Signature=OP4dDSd7vmviPkZ20GpbQDJs30MCU2KQbQfcVphOmZkUHaaAOmSRyZ0abfTZjAdpCqAMhqdRIu2vsMYf9S0WONGgSeyRSi1Bxj7wwo7sL~D6CmnJK5ZTMXF2xXH4pCuR1qqmj9VPqnuU1zDYxbdZPtNIWDXDBqH7dV-kRrquuMAeOcwQmLkteABVVdYnF29SfxkJNlX0cXeLUojViobtnwaVe~lBzRpUnV5CFSEwdxilGp4~cWdi9m3C1tXB1SkD-yYw2pKG1dWege211ewBYsqA9UCvKrfYfhat8goMrj~ZKdzyQqVjC0NDETMO2hDCzRjJGVhibh~3MkVBbl2B-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/7551246/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/7551246/mini_magick20190427-11750-86ex1c.png?1556364131"}],"downloadable_attachments_with_full_thumbnails":[{"id":7551246,"asset_id":1212765,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/7551246/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/7551246/eaat_review-libre.pdf?1390852038=\u0026response-content-disposition=attachment%3B+filename%3DNeuronal_high_affinity_sodium_dependent.pdf\u0026Expires=1733320512\u0026Signature=OP4dDSd7vmviPkZ20GpbQDJs30MCU2KQbQfcVphOmZkUHaaAOmSRyZ0abfTZjAdpCqAMhqdRIu2vsMYf9S0WONGgSeyRSi1Bxj7wwo7sL~D6CmnJK5ZTMXF2xXH4pCuR1qqmj9VPqnuU1zDYxbdZPtNIWDXDBqH7dV-kRrquuMAeOcwQmLkteABVVdYnF29SfxkJNlX0cXeLUojViobtnwaVe~lBzRpUnV5CFSEwdxilGp4~cWdi9m3C1tXB1SkD-yYw2pKG1dWege211ewBYsqA9UCvKrfYfhat8goMrj~ZKdzyQqVjC0NDETMO2hDCzRjJGVhibh~3MkVBbl2B-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/7551246/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/7551246/mini_magick20190427-11750-86ex1c.png?1556364131"}],"has_pdf":true,"has_fulltext":true,"page_count":27,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology","nofollow":false},{"id":37848,"name":"Neurodegenerative Diseases","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Diseases","nofollow":false},{"id":42973,"name":"Amyotrophic Lateral Sclerosis","url":"https://www.academia.edu/Documents/in/Amyotrophic_Lateral_Sclerosis","nofollow":false},{"id":61233,"name":"Glutamate","url":"https://www.academia.edu/Documents/in/Glutamate","nofollow":false},{"id":89802,"name":"Glutamate receptors","url":"https://www.academia.edu/Documents/in/Glutamate_receptors"},{"id":120789,"name":"Drug Design","url":"https://www.academia.edu/Documents/in/Drug_Design"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System"},{"id":176503,"name":"Synaptic Transmission","url":"https://www.academia.edu/Documents/in/Synaptic_Transmission"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons"},{"id":300829,"name":"Protein Sequence Analysis","url":"https://www.academia.edu/Documents/in/Protein_Sequence_Analysis"},{"id":386342,"name":"Sodium","url":"https://www.academia.edu/Documents/in/Sodium"},{"id":389152,"name":"Current","url":"https://www.academia.edu/Documents/in/Current"},{"id":527780,"name":"Neurodegenerative Disease","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Disease"},{"id":649537,"name":"Molecular Conformation","url":"https://www.academia.edu/Documents/in/Molecular_Conformation"},{"id":1120234,"name":"Alzheimer Disease","url":"https://www.academia.edu/Documents/in/Alzheimer_Disease"},{"id":1222191,"name":"Ligands","url":"https://www.academia.edu/Documents/in/Ligands"},{"id":1292998,"name":"Glutamic Acid","url":"https://www.academia.edu/Documents/in/Glutamic_Acid"},{"id":1703757,"name":"Glutamate Transporter","url":"https://www.academia.edu/Documents/in/Glutamate_Transporter"},{"id":1724844,"name":"Molecular Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure"},{"id":1953419,"name":"Neuroprotective Agents","url":"https://www.academia.edu/Documents/in/Neuroprotective_Agents"},{"id":2468093,"name":"Cell Membrane","url":"https://www.academia.edu/Documents/in/Cell_Membrane"}],"publication_year":2003,"publication_year_with_fallback":2003,"paper_rank":null,"all_time_views":49,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13332738 coauthored" data-work_id="13332738" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13332738/Development_of_piperazine_tethered_heterodimers_as_potent_antimalarials_against_chloroquine_resistant_P_falciparum_strains_Synthesis_and_molecular_modeling">Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13332738" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="536bca87f2f183e734d4d1f56bbc197e" rel="nofollow" data-download="{"attachment_id":45455969,"asset_id":13332738,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45455969/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32572439" href="https://independent.academia.edu/StefaniaButini">Stefania Butini</a><script data-card-contents-for-user="32572439" type="text/json">{"id":32572439,"first_name":"Stefania","last_name":"Butini","domain_name":"independent","page_name":"StefaniaButini","display_name":"Stefania Butini","profile_url":"https://independent.academia.edu/StefaniaButini","photo":"https://0.academia-photos.com/32572439/24534962/23427205/s65_stefania.butini.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-13332738">+3</span><div class="hidden js-additional-users-13332738"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/DonatellaTaramelli">Donatella Taramelli</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://unina.academia.edu/Catalanotti">bruno Catalanotti</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-13332738'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-13332738').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_13332738 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13332738"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13332738, container: ".js-paper-rank-work_13332738", }); });</script></li><li class="js-percentile-work_13332738 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13332738; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13332738"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13332738 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13332738"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13332738; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13332738]").text(description); $(".js-view-count-work_13332738").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13332738").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13332738"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="531" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23390" href="https://www.academia.edu/Documents/in/Pharmaceutical_Chemistry">Pharmaceutical Chemistry</a>, <script data-card-contents-for-ri="23390" type="text/json">{"id":23390,"name":"Pharmaceutical Chemistry","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="32927" href="https://www.academia.edu/Documents/in/Molecular_modeling">Molecular modeling</a>, <script data-card-contents-for-ri="32927" type="text/json">{"id":32927,"name":"Molecular modeling","url":"https://www.academia.edu/Documents/in/Molecular_modeling","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="102583" href="https://www.academia.edu/Documents/in/Drug_Resistance">Drug Resistance</a><script data-card-contents-for-ri="102583" type="text/json">{"id":102583,"name":"Drug Resistance","url":"https://www.academia.edu/Documents/in/Drug_Resistance","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13332738]'), work: {"id":13332738,"title":"Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling","created_at":"2015-06-26T15:08:20.486-07:00","owner_id":32572439,"url":"https://www.academia.edu/13332738/Development_of_piperazine_tethered_heterodimers_as_potent_antimalarials_against_chloroquine_resistant_P_falciparum_strains_Synthesis_and_molecular_modeling","slug":"Development_of_piperazine_tethered_heterodimers_as_potent_antimalarials_against_chloroquine_resistant_P_falciparum_strains_Synthesis_and_molecular_modeling","dom_id":"work_13332738","summary":null,"publication":"Bioorganic \u0026 Medicinal Chemistry Letters","publication_with_fallback":"Bioorganic \u0026 Medicinal Chemistry Letters","downloadable_attachments":[{"id":45455969,"asset_id":13332738,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/45455969/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/45455969/Development_of_piperazine-tethered_heter20160508-26809-6kcmq3-libre.pdf?1462734407=\u0026response-content-disposition=attachment%3B+filename%3DDevelopment_of_piperazine_tethered_heter.pdf\u0026Expires=1733320512\u0026Signature=KAGSY6QZObPQIXiY-6OuvmoXBKVNWsYJ0vw55Oo2nyN1Tub3h1ETOhAnknmXHD3bVHRbSJYIwnIvS4GG1K8qX9IFcUliMRA9cwSnIK~tsPxowcbUPazBpZuUjeehv-p~myVdphU9wiAiAA2h7TO70Z8XD3mL2qLjmTsuVxS6ijimfUsss0n506RT~ZJsf3haMUyDjp32J7gp3pNC1JHG0Dbgceuy1PHWHmlvLg5M5ImM43wouLr1EbAU7TG0AoYN0dX2uFleYWl3ujOsczSKqBqwmfa5yGbhNjI5XFAOIziDoeY8Q3TlsuleglKL-S4JLaNA~uoVAkJbc2-M6pWKUQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/45455969/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/45455969/mini_magick20190212-27160-1ejrhy.png?1549964248"}],"downloadable_attachments_with_full_thumbnails":[{"id":45455969,"asset_id":13332738,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/45455969/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/45455969/Development_of_piperazine-tethered_heter20160508-26809-6kcmq3-libre.pdf?1462734407=\u0026response-content-disposition=attachment%3B+filename%3DDevelopment_of_piperazine_tethered_heter.pdf\u0026Expires=1733320512\u0026Signature=KAGSY6QZObPQIXiY-6OuvmoXBKVNWsYJ0vw55Oo2nyN1Tub3h1ETOhAnknmXHD3bVHRbSJYIwnIvS4GG1K8qX9IFcUliMRA9cwSnIK~tsPxowcbUPazBpZuUjeehv-p~myVdphU9wiAiAA2h7TO70Z8XD3mL2qLjmTsuVxS6ijimfUsss0n506RT~ZJsf3haMUyDjp32J7gp3pNC1JHG0Dbgceuy1PHWHmlvLg5M5ImM43wouLr1EbAU7TG0AoYN0dX2uFleYWl3ujOsczSKqBqwmfa5yGbhNjI5XFAOIziDoeY8Q3TlsuleglKL-S4JLaNA~uoVAkJbc2-M6pWKUQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/45455969/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/45455969/mini_magick20190212-27160-1ejrhy.png?1549964248"}],"has_pdf":true,"has_fulltext":true,"page_count":5,"ordered_authors":[{"id":32572439,"first_name":"Stefania","last_name":"Butini","domain_name":"independent","page_name":"StefaniaButini","display_name":"Stefania Butini","profile_url":"https://independent.academia.edu/StefaniaButini","photo":"https://0.academia-photos.com/32572439/24534962/23427205/s65_stefania.butini.jpg"},{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"},{"id":36869933,"first_name":"Donatella","last_name":"Taramelli","domain_name":"independent","page_name":"DonatellaTaramelli","display_name":"Donatella Taramelli","profile_url":"https://independent.academia.edu/DonatellaTaramelli","photo":"/images/s65_no_pic.png"},{"id":21109383,"first_name":"bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"Catalanotti","display_name":"bruno Catalanotti","profile_url":"https://unina.academia.edu/Catalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false},{"id":23390,"name":"Pharmaceutical Chemistry","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Chemistry","nofollow":false},{"id":32927,"name":"Molecular modeling","url":"https://www.academia.edu/Documents/in/Molecular_modeling","nofollow":false},{"id":102583,"name":"Drug Resistance","url":"https://www.academia.edu/Documents/in/Drug_Resistance","nofollow":false},{"id":120789,"name":"Drug Design","url":"https://www.academia.edu/Documents/in/Drug_Design"},{"id":158597,"name":"Iron","url":"https://www.academia.edu/Documents/in/Iron"},{"id":255058,"name":"Metals","url":"https://www.academia.edu/Documents/in/Metals"},{"id":454230,"name":"Plasmodium falciparum","url":"https://www.academia.edu/Documents/in/Plasmodium_falciparum"},{"id":454707,"name":"Antimalarials","url":"https://www.academia.edu/Documents/in/Antimalarials"},{"id":590943,"name":"Metal ion","url":"https://www.academia.edu/Documents/in/Metal_ion"},{"id":649537,"name":"Molecular Conformation","url":"https://www.academia.edu/Documents/in/Molecular_Conformation"},{"id":728493,"name":"Bioorganic and medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Bioorganic_and_medicinal_Chemistry"},{"id":919274,"name":"Chloroquine","url":"https://www.academia.edu/Documents/in/Chloroquine"},{"id":1257974,"name":"Ions","url":"https://www.academia.edu/Documents/in/Ions"},{"id":1809037,"name":"Dimerization","url":"https://www.academia.edu/Documents/in/Dimerization"},{"id":2106543,"name":"Clotrimazole Uk","url":"https://www.academia.edu/Documents/in/Clotrimazole_Uk"},{"id":2356820,"name":"Clotrimazole","url":"https://www.academia.edu/Documents/in/Clotrimazole"}],"publication_year":2007,"publication_year_with_fallback":2007,"paper_rank":null,"all_time_views":13,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19424368 coauthored" data-work_id="19424368" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19424368/Specific_Targeting_Highly_Conserved_Residues_in_the_HIV_1_Reverse_Transcriptase_Primer_Grip_Region_Design_Synthesis_and_Biological_Evaluation_of_Novel_Potent_and_Broad_Spectrum_NNRTIs_with_Antiviral_Activity">Specific Targeting Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. Design, Synthesis, and Biological Evaluation of Novel, Potent, and Broad Spectrum NNRTIs with Antiviral Activity</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19424368" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d6e48a61b5c829167bac7e93b2474889" rel="nofollow" data-download="{"attachment_id":40613047,"asset_id":19424368,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40613047/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39697271" href="https://unisa-it.academia.edu/ManuelaRodriquez">Manuela Rodriquez</a><script data-card-contents-for-user="39697271" type="text/json">{"id":39697271,"first_name":"Manuela","last_name":"Rodriquez","domain_name":"unisa-it","page_name":"ManuelaRodriquez","display_name":"Manuela Rodriquez","profile_url":"https://unisa-it.academia.edu/ManuelaRodriquez","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-19424368">+2</span><div class="hidden js-additional-users-19424368"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/StefaniaButini">Stefania Butini</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-19424368'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-19424368').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_19424368 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19424368"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 19424368, container: ".js-paper-rank-work_19424368", }); });</script></li><li class="js-percentile-work_19424368 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19424368; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_19424368"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_19424368 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="19424368"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19424368; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19424368]").text(description); $(".js-view-count-work_19424368").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_19424368").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="19424368"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="531" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2375" href="https://www.academia.edu/Documents/in/Medicinal_Chemistry">Medicinal Chemistry</a>, <script data-card-contents-for-ri="2375" type="text/json">{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="17491" href="https://www.academia.edu/Documents/in/Macrophages">Macrophages</a>, <script data-card-contents-for-ri="17491" type="text/json">{"id":17491,"name":"Macrophages","url":"https://www.academia.edu/Documents/in/Macrophages","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="39978" href="https://www.academia.edu/Documents/in/HIV">HIV</a><script data-card-contents-for-ri="39978" type="text/json">{"id":39978,"name":"HIV","url":"https://www.academia.edu/Documents/in/HIV","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=19424368]'), work: {"id":19424368,"title":"Specific Targeting Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. Design, Synthesis, and Biological Evaluation of Novel, Potent, and Broad Spectrum NNRTIs with Antiviral Activity","created_at":"2015-12-03T11:12:51.420-08:00","owner_id":39697271,"url":"https://www.academia.edu/19424368/Specific_Targeting_Highly_Conserved_Residues_in_the_HIV_1_Reverse_Transcriptase_Primer_Grip_Region_Design_Synthesis_and_Biological_Evaluation_of_Novel_Potent_and_Broad_Spectrum_NNRTIs_with_Antiviral_Activity","slug":"Specific_Targeting_Highly_Conserved_Residues_in_the_HIV_1_Reverse_Transcriptase_Primer_Grip_Region_Design_Synthesis_and_Biological_Evaluation_of_Novel_Potent_and_Broad_Spectrum_NNRTIs_with_Antiviral_Activity","dom_id":"work_19424368","summary":null,"publication":"Journal of Medicinal Chemistry","publication_with_fallback":"Journal of Medicinal Chemistry","downloadable_attachments":[{"id":40613047,"asset_id":19424368,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/40613047/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/40613047/Specific_targeting_highly_conserved_resi20151203-30145-x93z9i-libre.pdf?1449170313=\u0026response-content-disposition=attachment%3B+filename%3DSpecific_Targeting_Highly_Conserved_Resi.pdf\u0026Expires=1733320512\u0026Signature=IUGl3ilKtADtnt9b8Rk8cnlClEieAv6VWaY3qygMoXw3gdDGo-4NbL0z8eSopbdwPLl8tNR9Ckl~AsC2EWty1S2UzSsiORAJ5l7~uktMcfC3eVEtHf-4a3227aAEwpFa9fyAuBhOW5yMPubbQAKTUWeO46HM73CSRv7cZWtmKyzDbvx6a0~VyGsQDyzwZcN5X13Zd0fQMW48G7EFrdOnNw1vKfGWpLaZOZ7RVUfpzJTS5YExZPg8lPDPU1AG9~9buVbb6tVFqEsT6r1~Pl-fXQHc9jnULqQwRcuyjo6rmSdv2p5oZKWGKP3lshv0c-WxBfSw7zEUXXos1fDvhEhetA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/40613047/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/40613047/mini_magick20220703-27679-1n0ksxb.png?1656857656"}],"downloadable_attachments_with_full_thumbnails":[{"id":40613047,"asset_id":19424368,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/40613047/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/40613047/Specific_targeting_highly_conserved_resi20151203-30145-x93z9i-libre.pdf?1449170313=\u0026response-content-disposition=attachment%3B+filename%3DSpecific_Targeting_Highly_Conserved_Resi.pdf\u0026Expires=1733320512\u0026Signature=IUGl3ilKtADtnt9b8Rk8cnlClEieAv6VWaY3qygMoXw3gdDGo-4NbL0z8eSopbdwPLl8tNR9Ckl~AsC2EWty1S2UzSsiORAJ5l7~uktMcfC3eVEtHf-4a3227aAEwpFa9fyAuBhOW5yMPubbQAKTUWeO46HM73CSRv7cZWtmKyzDbvx6a0~VyGsQDyzwZcN5X13Zd0fQMW48G7EFrdOnNw1vKfGWpLaZOZ7RVUfpzJTS5YExZPg8lPDPU1AG9~9buVbb6tVFqEsT6r1~Pl-fXQHc9jnULqQwRcuyjo6rmSdv2p5oZKWGKP3lshv0c-WxBfSw7zEUXXos1fDvhEhetA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/40613047/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/40613047/mini_magick20220703-27679-1n0ksxb.png?1656857656"}],"has_pdf":true,"has_fulltext":true,"page_count":13,"ordered_authors":[{"id":39697271,"first_name":"Manuela","last_name":"Rodriquez","domain_name":"unisa-it","page_name":"ManuelaRodriquez","display_name":"Manuela Rodriquez","profile_url":"https://unisa-it.academia.edu/ManuelaRodriquez","photo":"/images/s65_no_pic.png"},{"id":32572439,"first_name":"Stefania","last_name":"Butini","domain_name":"independent","page_name":"StefaniaButini","display_name":"Stefania Butini","profile_url":"https://independent.academia.edu/StefaniaButini","photo":"https://0.academia-photos.com/32572439/24534962/23427205/s65_stefania.butini.jpg"},{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false},{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry","nofollow":false},{"id":17491,"name":"Macrophages","url":"https://www.academia.edu/Documents/in/Macrophages","nofollow":false},{"id":39978,"name":"HIV","url":"https://www.academia.edu/Documents/in/HIV","nofollow":false},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":120789,"name":"Drug Design","url":"https://www.academia.edu/Documents/in/Drug_Design"},{"id":321836,"name":"Spectrum","url":"https://www.academia.edu/Documents/in/Spectrum"},{"id":446162,"name":"Medicinal","url":"https://www.academia.edu/Documents/in/Medicinal"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence"},{"id":902999,"name":"Antiviral Activity","url":"https://www.academia.edu/Documents/in/Antiviral_Activity"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship"}],"publication_year":2005,"publication_year_with_fallback":2005,"paper_rank":null,"all_time_views":30,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42024669" data-work_id="42024669" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42024669/2_DEOXY_8_PROPYN_1_YL_ADENOSINE_CONTAINING_Oligonucleotides_Effects_on_Stability_of_Duplex_and_Quadruplex_Structures">2′-DEOXY-8-(PROPYN-1-YL)ADENOSINE-CONTAINING Oligonucleotides: Effects on Stability of Duplex and Quadruplex Structures</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42024669" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="76dbe33050c400cc31c3b55df299cc1c" rel="nofollow" data-download="{"attachment_id":62149840,"asset_id":42024669,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/62149840/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_42024669 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42024669"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42024669, container: ".js-paper-rank-work_42024669", }); });</script></li><li class="js-percentile-work_42024669 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42024669; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_42024669"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_42024669 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="42024669"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42024669; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42024669]").text(description); $(".js-view-count-work_42024669").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42024669").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="42024669"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="531" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="21732" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy">Magnetic Resonance Spectroscopy</a>, <script data-card-contents-for-ri="21732" type="text/json">{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="48057" href="https://www.academia.edu/Documents/in/DNA">DNA</a>, <script data-card-contents-for-ri="48057" type="text/json">{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="61232" href="https://www.academia.edu/Documents/in/Adenosine">Adenosine</a><script data-card-contents-for-ri="61232" type="text/json">{"id":61232,"name":"Adenosine","url":"https://www.academia.edu/Documents/in/Adenosine","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=42024669]'), work: {"id":42024669,"title":"2′-DEOXY-8-(PROPYN-1-YL)ADENOSINE-CONTAINING Oligonucleotides: Effects on Stability of Duplex and Quadruplex Structures","created_at":"2020-02-20T03:27:02.844-08:00","owner_id":1110486,"url":"https://www.academia.edu/42024669/2_DEOXY_8_PROPYN_1_YL_ADENOSINE_CONTAINING_Oligonucleotides_Effects_on_Stability_of_Duplex_and_Quadruplex_Structures","slug":"2_DEOXY_8_PROPYN_1_YL_ADENOSINE_CONTAINING_Oligonucleotides_Effects_on_Stability_of_Duplex_and_Quadruplex_Structures","dom_id":"work_42024669","summary":null,"publication":"Bioorganic \u0026 Medicinal Chemistry Letters","publication_with_fallback":"Bioorganic \u0026 Medicinal Chemistry Letters","downloadable_attachments":[{"id":62149840,"asset_id":42024669,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149840/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149840/s0960-894x_2800_2900381-420200220-17565-1sb1nyv-libre.pdf?1582199235=\u0026response-content-disposition=attachment%3B+filename%3D2_DEOXY_8_PROPYN_1_YL_ADENOSINE_CONTAINI.pdf\u0026Expires=1733320512\u0026Signature=GlL8WibJ6Gl5xdHZeQ5X2zmXGXY8VSBUNfYJF2fknTWD1OmUWc306vE1egQgzkmyHw~jsY3~mxQ4GmQWMsqYe3ZOgZhuaEgoJotqE~QnGNZ-Ichogn2vlRUfvPKmb8n~Dm-XH-gYFczihUFgZ5NNw-F32E2yYG7tx8oCJaHSWt724gGWWBiXOMbGI8RKBjGRvZ7IFvJfws3fRwEn-MVC3oPKtQrUly~gWT-UkywOVib4RHADOcpimCff8ns5GvIMnIQ-O~9xDrvni0W7WXlG2DvrJynk0sRyM8uw4lSStebsVaD~0OvXZ2SaP4ONUAsE8xPnlfv2SyIDVxz0bVtrSA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149840/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149840/mini_magick20200220-17565-6ne4wy.png?1582198357"}],"downloadable_attachments_with_full_thumbnails":[{"id":62149840,"asset_id":42024669,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149840/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149840/s0960-894x_2800_2900381-420200220-17565-1sb1nyv-libre.pdf?1582199235=\u0026response-content-disposition=attachment%3B+filename%3D2_DEOXY_8_PROPYN_1_YL_ADENOSINE_CONTAINI.pdf\u0026Expires=1733320512\u0026Signature=GlL8WibJ6Gl5xdHZeQ5X2zmXGXY8VSBUNfYJF2fknTWD1OmUWc306vE1egQgzkmyHw~jsY3~mxQ4GmQWMsqYe3ZOgZhuaEgoJotqE~QnGNZ-Ichogn2vlRUfvPKmb8n~Dm-XH-gYFczihUFgZ5NNw-F32E2yYG7tx8oCJaHSWt724gGWWBiXOMbGI8RKBjGRvZ7IFvJfws3fRwEn-MVC3oPKtQrUly~gWT-UkywOVib4RHADOcpimCff8ns5GvIMnIQ-O~9xDrvni0W7WXlG2DvrJynk0sRyM8uw4lSStebsVaD~0OvXZ2SaP4ONUAsE8xPnlfv2SyIDVxz0bVtrSA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149840/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149840/mini_magick20200220-17565-6ne4wy.png?1582198357"}],"has_pdf":true,"has_fulltext":true,"page_count":5,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy","nofollow":false},{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA","nofollow":false},{"id":61232,"name":"Adenosine","url":"https://www.academia.edu/Documents/in/Adenosine","nofollow":false},{"id":69825,"name":"Negative Affect","url":"https://www.academia.edu/Documents/in/Negative_Affect"},{"id":76407,"name":"Circular Dichroism","url":"https://www.academia.edu/Documents/in/Circular_Dichroism"},{"id":389180,"name":"Thermal Stability","url":"https://www.academia.edu/Documents/in/Thermal_Stability"},{"id":728493,"name":"Bioorganic and medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Bioorganic_and_medicinal_Chemistry"},{"id":1362652,"name":"Nucleic Acid Conformation","url":"https://www.academia.edu/Documents/in/Nucleic_Acid_Conformation"}],"publication_year":2000,"publication_year_with_fallback":2000,"paper_rank":null,"all_time_views":2,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42024684" data-work_id="42024684" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42024684/Synthesis_of_5_METHYLAMINO_2_DEOXYURIDINE_Derivatives">Synthesis of 5-METHYLAMINO-2′-DEOXYURIDINE Derivatives</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42024684" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="491a882c3863b2ed867bb7007ab4d994" rel="nofollow" data-download="{"attachment_id":62149821,"asset_id":42024684,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/62149821/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_42024684 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42024684"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42024684, container: ".js-paper-rank-work_42024684", }); });</script></li><li class="js-percentile-work_42024684 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42024684; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_42024684"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_42024684 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="42024684"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42024684; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42024684]").text(description); $(".js-view-count-work_42024684").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42024684").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="42024684"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="21732" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy">Magnetic Resonance Spectroscopy</a>, <script data-card-contents-for-ri="21732" type="text/json">{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="83838" href="https://www.academia.edu/Documents/in/Amines">Amines</a>, <script data-card-contents-for-ri="83838" type="text/json">{"id":83838,"name":"Amines","url":"https://www.academia.edu/Documents/in/Amines","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="178906" href="https://www.academia.edu/Documents/in/Nucleic_Acids">Nucleic Acids</a>, <script data-card-contents-for-ri="178906" type="text/json">{"id":178906,"name":"Nucleic Acids","url":"https://www.academia.edu/Documents/in/Nucleic_Acids","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="963360" href="https://www.academia.edu/Documents/in/Nucleosides">Nucleosides</a><script data-card-contents-for-ri="963360" type="text/json">{"id":963360,"name":"Nucleosides","url":"https://www.academia.edu/Documents/in/Nucleosides","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=42024684]'), work: {"id":42024684,"title":"Synthesis of 5-METHYLAMINO-2′-DEOXYURIDINE Derivatives","created_at":"2020-02-20T03:27:04.223-08:00","owner_id":1110486,"url":"https://www.academia.edu/42024684/Synthesis_of_5_METHYLAMINO_2_DEOXYURIDINE_Derivatives","slug":"Synthesis_of_5_METHYLAMINO_2_DEOXYURIDINE_Derivatives","dom_id":"work_42024684","summary":null,"publication":"Nucleosides, Nucleotides and Nucleic Acids","publication_with_fallback":"Nucleosides, Nucleotides and Nucleic Acids","downloadable_attachments":[{"id":62149821,"asset_id":42024684,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149821/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149821/Synthesis_of_5-methylamino-2_-deoxyurid20200220-17573-1woorbr.pdf?1582198233=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_of_5_METHYLAMINO_2_DEOXYURIDIN.pdf\u0026Expires=1733320513\u0026Signature=cjO0~FBC~3QpvrO-vxrUvWbOhWoFYxCcu~Ds6~sG7gDiQDv-wE7foSdR9qowIVQ0Ke4yqhpqBsRo6xnANLeEiVvYMNtR0nwrFsdqMhhKo6bnkR5Tl2-fT8OF6kcEYRON-ZXJXNwyxyXHTUw3Z8idxEoetz3UrPsJwRftgEh~U3B5AFJ2sfkFhHN1lcJB8VF0rGBq6UZPnG5CHpI1xAS6bUpCz4o2T4S2Mzf3qbvpoozGt2AQ5nojVqFBIy~~92NC9JeiXXWYKrthE9sLt6aWlsR4U6d5d0k5YS78oQbKOzW90ifWI1S0CrovIp8pwkHh4VmJ560yARbhpwr1CdHwOw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149821/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149821/mini_magick20200220-17573-1ev9eag.png?1582198373"}],"downloadable_attachments_with_full_thumbnails":[{"id":62149821,"asset_id":42024684,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149821/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149821/Synthesis_of_5-methylamino-2_-deoxyurid20200220-17573-1woorbr.pdf?1582198233=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_of_5_METHYLAMINO_2_DEOXYURIDIN.pdf\u0026Expires=1733320513\u0026Signature=cjO0~FBC~3QpvrO-vxrUvWbOhWoFYxCcu~Ds6~sG7gDiQDv-wE7foSdR9qowIVQ0Ke4yqhpqBsRo6xnANLeEiVvYMNtR0nwrFsdqMhhKo6bnkR5Tl2-fT8OF6kcEYRON-ZXJXNwyxyXHTUw3Z8idxEoetz3UrPsJwRftgEh~U3B5AFJ2sfkFhHN1lcJB8VF0rGBq6UZPnG5CHpI1xAS6bUpCz4o2T4S2Mzf3qbvpoozGt2AQ5nojVqFBIy~~92NC9JeiXXWYKrthE9sLt6aWlsR4U6d5d0k5YS78oQbKOzW90ifWI1S0CrovIp8pwkHh4VmJ560yARbhpwr1CdHwOw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149821/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149821/mini_magick20200220-17573-1ev9eag.png?1582198373"}],"has_pdf":true,"has_fulltext":true,"page_count":12,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy","nofollow":false},{"id":83838,"name":"Amines","url":"https://www.academia.edu/Documents/in/Amines","nofollow":false},{"id":178906,"name":"Nucleic Acids","url":"https://www.academia.edu/Documents/in/Nucleic_Acids","nofollow":false},{"id":963360,"name":"Nucleosides","url":"https://www.academia.edu/Documents/in/Nucleosides","nofollow":false},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":2506577,"name":" Deoxyuridine.","url":"https://www.academia.edu/Documents/in/Deoxyuridine"}],"publication_year":2001,"publication_year_with_fallback":2001,"paper_rank":null,"all_time_views":4,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42024685" data-work_id="42024685" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42024685/Oligonucleotides_Containing_an_Acridine_Group_Covalently_Bonded_to_the_Nucleotide_Flanking_the_3_3_Phosphodiester_Junction_for_Alternate_Strand_Triple_Helix_Formation">Oligonucleotides Containing an Acridine Group Covalently Bonded to the Nucleotide Flanking the 3′-3′ Phosphodiester Junction for Alternate Strand Triple Helix Formation</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42024685" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fef853df85354a7e620f92de326f3bd8" rel="nofollow" data-download="{"attachment_id":62149829,"asset_id":42024685,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/62149829/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_42024685 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42024685"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42024685, container: ".js-paper-rank-work_42024685", }); });</script></li><li class="js-percentile-work_42024685 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42024685; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_42024685"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_42024685 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="42024685"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42024685; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42024685]").text(description); $(".js-view-count-work_42024685").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42024685").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="42024685"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="35637" href="https://www.academia.edu/Documents/in/Molecular_Mechanics">Molecular Mechanics</a>, <script data-card-contents-for-ri="35637" type="text/json">{"id":35637,"name":"Molecular Mechanics","url":"https://www.academia.edu/Documents/in/Molecular_Mechanics","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="95266" href="https://www.academia.edu/Documents/in/Triple_Helix">Triple Helix</a>, <script data-card-contents-for-ri="95266" type="text/json">{"id":95266,"name":"Triple Helix","url":"https://www.academia.edu/Documents/in/Triple_Helix","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="178906" href="https://www.academia.edu/Documents/in/Nucleic_Acids">Nucleic Acids</a>, <script data-card-contents-for-ri="178906" type="text/json">{"id":178906,"name":"Nucleic Acids","url":"https://www.academia.edu/Documents/in/Nucleic_Acids","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="541785" href="https://www.academia.edu/Documents/in/Phosphates">Phosphates</a><script data-card-contents-for-ri="541785" type="text/json">{"id":541785,"name":"Phosphates","url":"https://www.academia.edu/Documents/in/Phosphates","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=42024685]'), work: {"id":42024685,"title":"Oligonucleotides Containing an Acridine Group Covalently Bonded to the Nucleotide Flanking the 3′-3′ Phosphodiester Junction for Alternate Strand Triple Helix Formation","created_at":"2020-02-20T03:27:04.310-08:00","owner_id":1110486,"url":"https://www.academia.edu/42024685/Oligonucleotides_Containing_an_Acridine_Group_Covalently_Bonded_to_the_Nucleotide_Flanking_the_3_3_Phosphodiester_Junction_for_Alternate_Strand_Triple_Helix_Formation","slug":"Oligonucleotides_Containing_an_Acridine_Group_Covalently_Bonded_to_the_Nucleotide_Flanking_the_3_3_Phosphodiester_Junction_for_Alternate_Strand_Triple_Helix_Formation","dom_id":"work_42024685","summary":null,"publication":"Nucleosides, Nucleotides and Nucleic Acids","publication_with_fallback":"Nucleosides, Nucleotides and Nucleic Acids","downloadable_attachments":[{"id":62149829,"asset_id":42024685,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149829/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149829/chin.20040618620200220-17570-r9m27l-libre.pdf?1582199238=\u0026response-content-disposition=attachment%3B+filename%3DOligonucleotides_Containing_an_Acridine.pdf\u0026Expires=1733320513\u0026Signature=KAinICjgEZ9MSsHX~2VspRp5fc5S6bpXeZYKzjf08mjbBB~6wWR5cCJYfmrErikv7cGQ~QdxLCmcv6GsKFCPlf41IxyMBdpodUSQgqanJhQuCfCFFotjKWHNysqMzWrUQo0Hk6lXbhSDyv5XY5c5-D8SQ9dhlA0CW~ZTx6k8rDptJ0csRpmt35Uc0rudK78pNrf1dDrMi0N-1diuBixCrndNTfJAfvhWs6xpOH7z4Pb~sPAGDa3Wxj5ewAJZzi1u7KgQXH3JXToaQxQ7Y2RVXoeuqsylN91JxEG83qCyqFPIKFhVEZjfqdLbFQHHrCQU0b58otxuBZUdDw1bEwpcAQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149829/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149829/mini_magick20200220-17570-qebceu.png?1582198343"}],"downloadable_attachments_with_full_thumbnails":[{"id":62149829,"asset_id":42024685,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149829/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149829/chin.20040618620200220-17570-r9m27l-libre.pdf?1582199238=\u0026response-content-disposition=attachment%3B+filename%3DOligonucleotides_Containing_an_Acridine.pdf\u0026Expires=1733320513\u0026Signature=KAinICjgEZ9MSsHX~2VspRp5fc5S6bpXeZYKzjf08mjbBB~6wWR5cCJYfmrErikv7cGQ~QdxLCmcv6GsKFCPlf41IxyMBdpodUSQgqanJhQuCfCFFotjKWHNysqMzWrUQo0Hk6lXbhSDyv5XY5c5-D8SQ9dhlA0CW~ZTx6k8rDptJ0csRpmt35Uc0rudK78pNrf1dDrMi0N-1diuBixCrndNTfJAfvhWs6xpOH7z4Pb~sPAGDa3Wxj5ewAJZzi1u7KgQXH3JXToaQxQ7Y2RVXoeuqsylN91JxEG83qCyqFPIKFhVEZjfqdLbFQHHrCQU0b58otxuBZUdDw1bEwpcAQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149829/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149829/mini_magick20200220-17570-qebceu.png?1582198343"}],"has_pdf":true,"has_fulltext":true,"page_count":1,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":35637,"name":"Molecular Mechanics","url":"https://www.academia.edu/Documents/in/Molecular_Mechanics","nofollow":false},{"id":95266,"name":"Triple Helix","url":"https://www.academia.edu/Documents/in/Triple_Helix","nofollow":false},{"id":178906,"name":"Nucleic Acids","url":"https://www.academia.edu/Documents/in/Nucleic_Acids","nofollow":false},{"id":541785,"name":"Phosphates","url":"https://www.academia.edu/Documents/in/Phosphates","nofollow":false},{"id":649537,"name":"Molecular Conformation","url":"https://www.academia.edu/Documents/in/Molecular_Conformation"},{"id":1362652,"name":"Nucleic Acid Conformation","url":"https://www.academia.edu/Documents/in/Nucleic_Acid_Conformation"},{"id":1597877,"name":"Nucleotides","url":"https://www.academia.edu/Documents/in/Nucleotides"},{"id":1649745,"name":"Oligonucleotides","url":"https://www.academia.edu/Documents/in/Oligonucleotides"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":2205703,"name":"Oligonucleotide","url":"https://www.academia.edu/Documents/in/Oligonucleotide"}],"publication_year":2003,"publication_year_with_fallback":2003,"paper_rank":null,"all_time_views":3,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42024686" data-work_id="42024686" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42024686/Insight_into_the_mechanism_of_action_of_plakortins_simple_1_2_dioxane_antimalarials">Insight into the mechanism of action of plakortins, simple 1,2-dioxane antimalarials</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42024686" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fd83b4d686820f40966fd1f6cae26305" rel="nofollow" data-download="{"attachment_id":62149822,"asset_id":42024686,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/62149822/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_42024686 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42024686"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42024686, container: ".js-paper-rank-work_42024686", }); });</script></li><li class="js-percentile-work_42024686 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42024686; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_42024686"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_42024686 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="42024686"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42024686; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42024686]").text(description); $(".js-view-count-work_42024686").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42024686").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="42024686"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="531" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="24567" href="https://www.academia.edu/Documents/in/Porifera">Porifera</a>, <script data-card-contents-for-ri="24567" type="text/json">{"id":24567,"name":"Porifera","url":"https://www.academia.edu/Documents/in/Porifera","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="157521" href="https://www.academia.edu/Documents/in/Quantitative_Structure_Activity_Relationship">Quantitative Structure Activity Relationship</a>, <script data-card-contents-for-ri="157521" type="text/json">{"id":157521,"name":"Quantitative Structure Activity Relationship","url":"https://www.academia.edu/Documents/in/Quantitative_Structure_Activity_Relationship","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="454230" href="https://www.academia.edu/Documents/in/Plasmodium_falciparum">Plasmodium falciparum</a><script data-card-contents-for-ri="454230" type="text/json">{"id":454230,"name":"Plasmodium falciparum","url":"https://www.academia.edu/Documents/in/Plasmodium_falciparum","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=42024686]'), work: {"id":42024686,"title":"Insight into the mechanism of action of plakortins, simple 1,2-dioxane antimalarials","created_at":"2020-02-20T03:27:04.394-08:00","owner_id":1110486,"url":"https://www.academia.edu/42024686/Insight_into_the_mechanism_of_action_of_plakortins_simple_1_2_dioxane_antimalarials","slug":"Insight_into_the_mechanism_of_action_of_plakortins_simple_1_2_dioxane_antimalarials","dom_id":"work_42024686","summary":null,"publication":"Organic \u0026 Biomolecular Chemistry","publication_with_fallback":"Organic \u0026 Biomolecular Chemistry","downloadable_attachments":[{"id":62149822,"asset_id":42024686,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149822/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149822/Insight_into_the_mechanism_of_action_of_20200220-17573-1fm3dpm.pdf?1582198234=\u0026response-content-disposition=attachment%3B+filename%3DInsight_into_the_mechanism_of_action_of.pdf\u0026Expires=1733320513\u0026Signature=ROtChSeC~ZbLxgphQnsyUXomGkvwaBpGV9mA7Lsw7lpI1WSDF0Duj6v4iVwkC4ItbqSVKosPf4~2qN9BJfcZykUGAIMK2pJrw0Mq46GZZtKSnb~UdV5USpcZoPfyHjiuhtYcYdcw1WuBnBBeXBw7yYksUNSMSzd8LpH8Ho7MVM8hYfED8jXeNYgEOwG53ngr-ie5SM~yzQZNffzAh5VBCQJCpaIP1iiHR7CVadiSGctj15OiEc1dOJ62H3Nd~IPW2YjUAooBloq1ibdK2shD2t5pEhne96mfrlKi2h7PPhe780mxRu0Yt1utQMrPmN1vU8ZCDoWcd2xKLqJb0~T48Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149822/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149822/mini_magick20200220-17565-u4oiii.png?1582198381"}],"downloadable_attachments_with_full_thumbnails":[{"id":62149822,"asset_id":42024686,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149822/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149822/Insight_into_the_mechanism_of_action_of_20200220-17573-1fm3dpm.pdf?1582198234=\u0026response-content-disposition=attachment%3B+filename%3DInsight_into_the_mechanism_of_action_of.pdf\u0026Expires=1733320513\u0026Signature=ROtChSeC~ZbLxgphQnsyUXomGkvwaBpGV9mA7Lsw7lpI1WSDF0Duj6v4iVwkC4ItbqSVKosPf4~2qN9BJfcZykUGAIMK2pJrw0Mq46GZZtKSnb~UdV5USpcZoPfyHjiuhtYcYdcw1WuBnBBeXBw7yYksUNSMSzd8LpH8Ho7MVM8hYfED8jXeNYgEOwG53ngr-ie5SM~yzQZNffzAh5VBCQJCpaIP1iiHR7CVadiSGctj15OiEc1dOJ62H3Nd~IPW2YjUAooBloq1ibdK2shD2t5pEhne96mfrlKi2h7PPhe780mxRu0Yt1utQMrPmN1vU8ZCDoWcd2xKLqJb0~T48Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149822/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149822/mini_magick20200220-17565-u4oiii.png?1582198381"}],"has_pdf":true,"has_fulltext":true,"page_count":11,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false},{"id":24567,"name":"Porifera","url":"https://www.academia.edu/Documents/in/Porifera","nofollow":false},{"id":157521,"name":"Quantitative Structure Activity Relationship","url":"https://www.academia.edu/Documents/in/Quantitative_Structure_Activity_Relationship","nofollow":false},{"id":454230,"name":"Plasmodium falciparum","url":"https://www.academia.edu/Documents/in/Plasmodium_falciparum","nofollow":false},{"id":454707,"name":"Antimalarials","url":"https://www.academia.edu/Documents/in/Antimalarials"},{"id":725615,"name":"Mechanism of action","url":"https://www.academia.edu/Documents/in/Mechanism_of_action"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship"},{"id":1771072,"name":"Dioxins","url":"https://www.academia.edu/Documents/in/Dioxins"}],"publication_year":2010,"publication_year_with_fallback":2010,"paper_rank":null,"all_time_views":5,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42024687" data-work_id="42024687" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42024687/Full_relative_stereochemistry_assignment_and_conformational_analysis_of_13_19_didesmethyl_spirolide_C_via_NMR_and_molecular_modeling_based_techniques_A_step_towards_understanding_spirolide_s_mechanism_of_action">Full relative stereochemistry assignment and conformational analysis of 13,19-didesmethyl spirolide C via NMR- and molecular modeling-based techniques. A step towards understanding spirolide’s mechanism of action</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42024687" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3ec139aedc804fadd255dfd981cab826" rel="nofollow" data-download="{"attachment_id":62149823,"asset_id":42024687,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/62149823/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_42024687 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42024687"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42024687, container: ".js-paper-rank-work_42024687", }); });</script></li><li class="js-percentile-work_42024687 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42024687; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_42024687"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_42024687 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="42024687"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42024687; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42024687]").text(description); $(".js-view-count-work_42024687").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42024687").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="42024687"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="531" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="21732" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy">Magnetic Resonance Spectroscopy</a>, <script data-card-contents-for-ri="21732" type="text/json">{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="32927" href="https://www.academia.edu/Documents/in/Molecular_modeling">Molecular modeling</a>, <script data-card-contents-for-ri="32927" type="text/json">{"id":32927,"name":"Molecular modeling","url":"https://www.academia.edu/Documents/in/Molecular_modeling","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="597890" href="https://www.academia.edu/Documents/in/Conformational_Analysis">Conformational Analysis</a><script data-card-contents-for-ri="597890" type="text/json">{"id":597890,"name":"Conformational Analysis","url":"https://www.academia.edu/Documents/in/Conformational_Analysis","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=42024687]'), work: {"id":42024687,"title":"Full relative stereochemistry assignment and conformational analysis of 13,19-didesmethyl spirolide C via NMR- and molecular modeling-based techniques. A step towards understanding spirolide’s mechanism of action","created_at":"2020-02-20T03:27:04.485-08:00","owner_id":1110486,"url":"https://www.academia.edu/42024687/Full_relative_stereochemistry_assignment_and_conformational_analysis_of_13_19_didesmethyl_spirolide_C_via_NMR_and_molecular_modeling_based_techniques_A_step_towards_understanding_spirolide_s_mechanism_of_action","slug":"Full_relative_stereochemistry_assignment_and_conformational_analysis_of_13_19_didesmethyl_spirolide_C_via_NMR_and_molecular_modeling_based_techniques_A_step_towards_understanding_spirolide_s_mechanism_of_action","dom_id":"work_42024687","summary":null,"publication":"Organic \u0026 Biomolecular Chemistry","publication_with_fallback":"Organic \u0026 Biomolecular Chemistry","downloadable_attachments":[{"id":62149823,"asset_id":42024687,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149823/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149823/Full_relative_stereochemistry_assignment20200220-17573-14qdwsc.pdf?1582198235=\u0026response-content-disposition=attachment%3B+filename%3DFull_relative_stereochemistry_assignment.pdf\u0026Expires=1733320513\u0026Signature=gBDXATUDlR67p96h66QnHKFSGK48T7eB8mN43xY~eOLe4KbuUxHiIYb2fichIIIN~kYzsA~zil1IOIperdh53E~xQv-6gYqf2fLeQfPaZMmMvL~80ry9w6R9og~EMTr8pjxppN5mQrFf19QaEbUBWukyMUUj2lVI~0ciFTu-JQpTkZbNn0KUoRxty~xuz~F4gkFbqlzZNYgL39mDb2sVUoPgYrnJWeXkPGzc1uT8XqLxjvfk0hDpVG~azJgNeneHniuDAbm~D4cnVDT8UbKtgcIBWUkLfZjBX7uCer6iPrC-BvvDjFrRX8K1FjvG9I3Uqc5027mJ134wewLVEkh5Mw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149823/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149823/mini_magick20200220-17565-na3gk7.png?1582198359"}],"downloadable_attachments_with_full_thumbnails":[{"id":62149823,"asset_id":42024687,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149823/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149823/Full_relative_stereochemistry_assignment20200220-17573-14qdwsc.pdf?1582198235=\u0026response-content-disposition=attachment%3B+filename%3DFull_relative_stereochemistry_assignment.pdf\u0026Expires=1733320513\u0026Signature=gBDXATUDlR67p96h66QnHKFSGK48T7eB8mN43xY~eOLe4KbuUxHiIYb2fichIIIN~kYzsA~zil1IOIperdh53E~xQv-6gYqf2fLeQfPaZMmMvL~80ry9w6R9og~EMTr8pjxppN5mQrFf19QaEbUBWukyMUUj2lVI~0ciFTu-JQpTkZbNn0KUoRxty~xuz~F4gkFbqlzZNYgL39mDb2sVUoPgYrnJWeXkPGzc1uT8XqLxjvfk0hDpVG~azJgNeneHniuDAbm~D4cnVDT8UbKtgcIBWUkLfZjBX7uCer6iPrC-BvvDjFrRX8K1FjvG9I3Uqc5027mJ134wewLVEkh5Mw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149823/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149823/mini_magick20200220-17565-na3gk7.png?1582198359"}],"has_pdf":true,"has_fulltext":true,"page_count":9,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy","nofollow":false},{"id":32927,"name":"Molecular modeling","url":"https://www.academia.edu/Documents/in/Molecular_modeling","nofollow":false},{"id":597890,"name":"Conformational Analysis","url":"https://www.academia.edu/Documents/in/Conformational_Analysis","nofollow":false},{"id":649537,"name":"Molecular Conformation","url":"https://www.academia.edu/Documents/in/Molecular_Conformation"},{"id":725615,"name":"Mechanism of action","url":"https://www.academia.edu/Documents/in/Mechanism_of_action"}],"publication_year":2009,"publication_year_with_fallback":2009,"paper_rank":null,"all_time_views":10,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42024688" data-work_id="42024688" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42024688/ChemInform_Abstract_Syntheses_of_1_15N_2_Deoxyinosine_4_15N_2_DeoxyAICAR_and_1_15N_2_Deoxyguanosine">ChemInform Abstract: Syntheses of [1-15N]-2′-Deoxyinosine, [4-15N]-2′-DeoxyAICAR, and [1-15N]-2′-Deoxyguanosine</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42024688" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="71f187a0b105622fc3ad18c8ffb758a7" rel="nofollow" data-download="{"attachment_id":62149842,"asset_id":42024688,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/62149842/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_42024688 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42024688"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42024688, container: ".js-paper-rank-work_42024688", }); });</script></li><li class="js-percentile-work_42024688 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42024688; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_42024688"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_42024688 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="42024688"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42024688; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42024688]").text(description); $(".js-view-count-work_42024688").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42024688").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42024689" data-work_id="42024689" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42024689/Exploitation_of_a_very_small_peptide_nucleic_acid_as_a_new_inhibitor_of_miR_509_3p_involved_in_the_regulation_of_cystic_fibrosis_disease_gene_expression">Exploitation of a very small peptide nucleic acid as a new inhibitor of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Computational techniques, and in particular molecular dynamics (MD) simulations, have been successfully used as a complementary technique to predict and analyse the structural behaviour of nucleic acids, including peptide nucleic acid-... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_42024689" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Computational techniques, and in particular molecular dynamics (MD) simulations, have been successfully used as a complementary technique to predict and analyse the structural behaviour of nucleic acids, including peptide nucleic acid- (PNA-) RNA hybrids. This study shows that a 7-base long PNA complementary to the seed region of miR-509-3p, one of the miRNAs involved in the posttranscriptional regulation of the CFTR disease-gene of Cystic Fibrosis, and bearing suitable functionalization at its N- and C-ends aimed at improving its resistance to nucleases and cellular uptake, is able to revert the expression of the luciferase gene containing the 3&#39;UTR of the gene in A549 human lung cancer cells, in agreement with the MD results that pointed at the formation of a stable RNA/PNA heteroduplex notwithstanding the short sequence of the latter. The here reported results widen the interest towards the use of small PNAs as effective anti-miRNA agents.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42024689" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="24495ef5d1f98be7f49ad688cbb4fce8" rel="nofollow" data-download="{"attachment_id":62149827,"asset_id":42024689,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/62149827/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_42024689 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42024689"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42024689, container: ".js-paper-rank-work_42024689", }); });</script></li><li class="js-percentile-work_42024689 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42024689; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_42024689"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_42024689 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="42024689"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42024689; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42024689]").text(description); $(".js-view-count-work_42024689").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42024689").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="42024689"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="923" href="https://www.academia.edu/Documents/in/Technology">Technology</a>, <script data-card-contents-for-ri="923" type="text/json">{"id":923,"name":"Technology","url":"https://www.academia.edu/Documents/in/Technology","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2736" href="https://www.academia.edu/Documents/in/Molecular_Dynamics_Simulation">Molecular Dynamics Simulation</a>, <script data-card-contents-for-ri="2736" type="text/json">{"id":2736,"name":"Molecular Dynamics Simulation","url":"https://www.academia.edu/Documents/in/Molecular_Dynamics_Simulation","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6946" href="https://www.academia.edu/Documents/in/Cystic_Fibrosis">Cystic Fibrosis</a>, <script data-card-contents-for-ri="6946" type="text/json">{"id":6946,"name":"Cystic Fibrosis","url":"https://www.academia.edu/Documents/in/Cystic_Fibrosis","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a><script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=42024689]'), work: {"id":42024689,"title":"Exploitation of a very small peptide nucleic acid as a new inhibitor of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression","created_at":"2020-02-20T03:27:04.680-08:00","owner_id":1110486,"url":"https://www.academia.edu/42024689/Exploitation_of_a_very_small_peptide_nucleic_acid_as_a_new_inhibitor_of_miR_509_3p_involved_in_the_regulation_of_cystic_fibrosis_disease_gene_expression","slug":"Exploitation_of_a_very_small_peptide_nucleic_acid_as_a_new_inhibitor_of_miR_509_3p_involved_in_the_regulation_of_cystic_fibrosis_disease_gene_expression","dom_id":"work_42024689","summary":"Computational techniques, and in particular molecular dynamics (MD) simulations, have been successfully used as a complementary technique to predict and analyse the structural behaviour of nucleic acids, including peptide nucleic acid- (PNA-) RNA hybrids. This study shows that a 7-base long PNA complementary to the seed region of miR-509-3p, one of the miRNAs involved in the posttranscriptional regulation of the CFTR disease-gene of Cystic Fibrosis, and bearing suitable functionalization at its N- and C-ends aimed at improving its resistance to nucleases and cellular uptake, is able to revert the expression of the luciferase gene containing the 3\u0026#39;UTR of the gene in A549 human lung cancer cells, in agreement with the MD results that pointed at the formation of a stable RNA/PNA heteroduplex notwithstanding the short sequence of the latter. The here reported results widen the interest towards the use of small PNAs as effective anti-miRNA agents.","publication":"BioMed research international","publication_with_fallback":"BioMed research international","downloadable_attachments":[{"id":62149827,"asset_id":42024689,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149827/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149827/Exploitation_of_a_Very_Small_Peptide_Nuc20200220-17570-vrwzhe.pdf?1582198237=\u0026response-content-disposition=attachment%3B+filename%3DExploitation_of_a_very_small_peptide_nuc.pdf\u0026Expires=1733320513\u0026Signature=Vejzq8dUNjjsMinAHKHhnx6DyatnLFFbICjbFzR1550z3M0q1IwaPRWcMaZj7H70Nal5kHqImgIi9KIZ0~c6uLH3YvMS350ujWaan8JMcGKG7o376jHdJpreDraghgWdznRL5rdlroJV-XHxXkNekb-uxfYPR4GTJ3qo1L~jfWxtkRCbMft6xm4mkvoZQ~yrWJ1adFwOLRaoDx5vFjn9DYLkiy5vvz5~GPwhGJoQ-5Av0yMWbnAeZkg7wBQmjpXrfH~-iPUeyZCBuo-QZVtrPtH7qS46v1oBELzXzKq7hv-KTdxUE1rYVxer-373WLToK9JQV15M92VPDsjp4yJPWA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149827/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149827/mini_magick20200220-17573-11p4dx9.png?1582198387"}],"downloadable_attachments_with_full_thumbnails":[{"id":62149827,"asset_id":42024689,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149827/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149827/Exploitation_of_a_Very_Small_Peptide_Nuc20200220-17570-vrwzhe.pdf?1582198237=\u0026response-content-disposition=attachment%3B+filename%3DExploitation_of_a_very_small_peptide_nuc.pdf\u0026Expires=1733320513\u0026Signature=Vejzq8dUNjjsMinAHKHhnx6DyatnLFFbICjbFzR1550z3M0q1IwaPRWcMaZj7H70Nal5kHqImgIi9KIZ0~c6uLH3YvMS350ujWaan8JMcGKG7o376jHdJpreDraghgWdznRL5rdlroJV-XHxXkNekb-uxfYPR4GTJ3qo1L~jfWxtkRCbMft6xm4mkvoZQ~yrWJ1adFwOLRaoDx5vFjn9DYLkiy5vvz5~GPwhGJoQ-5Av0yMWbnAeZkg7wBQmjpXrfH~-iPUeyZCBuo-QZVtrPtH7qS46v1oBELzXzKq7hv-KTdxUE1rYVxer-373WLToK9JQV15M92VPDsjp4yJPWA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149827/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149827/mini_magick20200220-17573-11p4dx9.png?1582198387"}],"has_pdf":true,"has_fulltext":true,"page_count":11,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":923,"name":"Technology","url":"https://www.academia.edu/Documents/in/Technology","nofollow":false},{"id":2736,"name":"Molecular Dynamics Simulation","url":"https://www.academia.edu/Documents/in/Molecular_Dynamics_Simulation","nofollow":false},{"id":6946,"name":"Cystic Fibrosis","url":"https://www.academia.edu/Documents/in/Cystic_Fibrosis","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false},{"id":76407,"name":"Circular Dichroism","url":"https://www.academia.edu/Documents/in/Circular_Dichroism"},{"id":111973,"name":"Peptide Nucleic Acids","url":"https://www.academia.edu/Documents/in/Peptide_Nucleic_Acids"},{"id":222543,"name":"Biomed","url":"https://www.academia.edu/Documents/in/Biomed"},{"id":295854,"name":"microRNAs","url":"https://www.academia.edu/Documents/in/microRNAs"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"},{"id":3005391,"name":"Ultraviolet Rays","url":"https://www.academia.edu/Documents/in/Ultraviolet_Rays"}],"publication_year":2014,"publication_year_with_fallback":2014,"paper_rank":null,"all_time_views":9,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42024690" data-work_id="42024690" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42024690/ChemInform_Abstract_Synthetic_Polynucleotides_and_Analogues_as_Models_for_Studies_Concerning_DNA">ChemInform Abstract: Synthetic Polynucleotides and Analogues as Models for Studies Concerning DNA</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42024690" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="71d1e83cb4d586e0e04b75072b65c23b" rel="nofollow" data-download="{"attachment_id":62149825,"asset_id":42024690,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/62149825/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_42024690 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42024690"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42024690, container: ".js-paper-rank-work_42024690", }); });</script></li><li class="js-percentile-work_42024690 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42024690; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_42024690"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_42024690 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="42024690"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42024690; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42024690]").text(description); $(".js-view-count-work_42024690").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42024690").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42024691" data-work_id="42024691" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42024691/Structural_Model_of_the_hUbA1_UbcH10_Quaternary_Complex_In_Silico_and_Experimental_Analysis_of_the_Protein_Protein_Interactions_between_E1_E2_and_Ubiquitin">Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42024691" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b04e92c68ff0b1da8a74c4cf69c106e0" rel="nofollow" data-download="{"attachment_id":62149844,"asset_id":42024691,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/62149844/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_42024691 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42024691"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42024691, container: ".js-paper-rank-work_42024691", }); });</script></li><li class="js-percentile-work_42024691 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42024691; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_42024691"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_42024691 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="42024691"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42024691; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42024691]").text(description); $(".js-view-count-work_42024691").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42024691").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="42024691"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="48" href="https://www.academia.edu/Documents/in/Engineering">Engineering</a>, <script data-card-contents-for-ri="48" type="text/json">{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="146" href="https://www.academia.edu/Documents/in/Bioinformatics">Bioinformatics</a>, <script data-card-contents-for-ri="146" type="text/json">{"id":146,"name":"Bioinformatics","url":"https://www.academia.edu/Documents/in/Bioinformatics","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="498" href="https://www.academia.edu/Documents/in/Physics">Physics</a>, <script data-card-contents-for-ri="498" type="text/json">{"id":498,"name":"Physics","url":"https://www.academia.edu/Documents/in/Physics","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="523" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a><script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=42024691]'), work: {"id":42024691,"title":"Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin","created_at":"2020-02-20T03:27:04.865-08:00","owner_id":1110486,"url":"https://www.academia.edu/42024691/Structural_Model_of_the_hUbA1_UbcH10_Quaternary_Complex_In_Silico_and_Experimental_Analysis_of_the_Protein_Protein_Interactions_between_E1_E2_and_Ubiquitin","slug":"Structural_Model_of_the_hUbA1_UbcH10_Quaternary_Complex_In_Silico_and_Experimental_Analysis_of_the_Protein_Protein_Interactions_between_E1_E2_and_Ubiquitin","dom_id":"work_42024691","summary":null,"publication":"PLoS ONE","publication_with_fallback":"PLoS ONE","downloadable_attachments":[{"id":62149844,"asset_id":42024691,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149844/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149844/Structural_Model_of_the_hUbA1-UbcH10_Qua20200220-17570-1dxxx1q.pdf?1582198313=\u0026response-content-disposition=attachment%3B+filename%3DStructural_Model_of_the_hUbA1_UbcH10_Qua.pdf\u0026Expires=1733320514\u0026Signature=ZpfxUIvIdZw3PcVUkSWeIM3d-ijAdDTTIY3Hj0UknCMEVdiDL-7sOL3pH3daL8itxgy8I92HQOCk-KTlhVDK6CO2lhnRrhoAoz7azy8YGuzbVQFV3~Hkg6cQKY590TSG76yCf2ty4ql9QX95uZtruMGE8B63HkUpM8MyjjnVmZ5RbUq70DLn8fN0cX56K1cmxLWdvdNtA8mL-NwHVufZdVqPR8qmvCr4vxuPasbjbzd8vmyHdiFCoOGrrgZVoDSk-UJdArUaskFw9hN-nO~k9CoPNtMNNpwde7TsLetWWGpSCqN2u3VZ-I6E8t9a6nc84cgN7ETDumSSN~IZNTENVw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149844/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149844/mini_magick20220709-2498-1wcpd96.png?1657354144"}],"downloadable_attachments_with_full_thumbnails":[{"id":62149844,"asset_id":42024691,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149844/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149844/Structural_Model_of_the_hUbA1-UbcH10_Qua20200220-17570-1dxxx1q.pdf?1582198313=\u0026response-content-disposition=attachment%3B+filename%3DStructural_Model_of_the_hUbA1_UbcH10_Qua.pdf\u0026Expires=1733320514\u0026Signature=ZpfxUIvIdZw3PcVUkSWeIM3d-ijAdDTTIY3Hj0UknCMEVdiDL-7sOL3pH3daL8itxgy8I92HQOCk-KTlhVDK6CO2lhnRrhoAoz7azy8YGuzbVQFV3~Hkg6cQKY590TSG76yCf2ty4ql9QX95uZtruMGE8B63HkUpM8MyjjnVmZ5RbUq70DLn8fN0cX56K1cmxLWdvdNtA8mL-NwHVufZdVqPR8qmvCr4vxuPasbjbzd8vmyHdiFCoOGrrgZVoDSk-UJdArUaskFw9hN-nO~k9CoPNtMNNpwde7TsLetWWGpSCqN2u3VZ-I6E8t9a6nc84cgN7ETDumSSN~IZNTENVw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149844/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149844/mini_magick20220709-2498-1wcpd96.png?1657354144"}],"has_pdf":true,"has_fulltext":true,"page_count":14,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering","nofollow":false},{"id":146,"name":"Bioinformatics","url":"https://www.academia.edu/Documents/in/Bioinformatics","nofollow":false},{"id":498,"name":"Physics","url":"https://www.academia.edu/Documents/in/Physics","nofollow":false},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false},{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":2736,"name":"Molecular Dynamics Simulation","url":"https://www.academia.edu/Documents/in/Molecular_Dynamics_Simulation"},{"id":4233,"name":"Computational Biology","url":"https://www.academia.edu/Documents/in/Computational_Biology"},{"id":4600,"name":"Protein Structure Prediction","url":"https://www.academia.edu/Documents/in/Protein_Structure_Prediction"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":33441,"name":"Macromolecular X-Ray Crystallography","url":"https://www.academia.edu/Documents/in/Macromolecular_X-Ray_Crystallography"},{"id":55266,"name":"Ubiquitin","url":"https://www.academia.edu/Documents/in/Ubiquitin"},{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation"},{"id":151086,"name":"Peptides","url":"https://www.academia.edu/Documents/in/Peptides"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"},{"id":557718,"name":"Multienzyme complexes","url":"https://www.academia.edu/Documents/in/Multienzyme_complexes"},{"id":956752,"name":"Protein Quaternary Structure","url":"https://www.academia.edu/Documents/in/Protein_Quaternary_Structure"},{"id":2898895,"name":"binding sites","url":"https://www.academia.edu/Documents/in/binding_sites"}],"publication_year":2014,"publication_year_with_fallback":2014,"paper_rank":null,"all_time_views":230,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42024698" data-work_id="42024698" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42024698/Oligonucleotides_Containing_an_Acridine_Group_Covalently_Bonded_to_the_Nucleotide_Flanking_the_3_3_Phosphodiester_Junction_for_Alternate_Strand_Triple_Helix_Formation">Oligonucleotides Containing an Acridine Group Covalently Bonded to the Nucleotide Flanking the 3′-3′ Phosphodiester Junction for Alternate Strand Triple Helix Formation</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42024698" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7e640afd60fd6a68a9fc4de3f766c6c5" rel="nofollow" data-download="{"attachment_id":62149830,"asset_id":42024698,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/62149830/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_42024698 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="42024698"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 42024698, container: ".js-paper-rank-work_42024698", }); });</script></li><li class="js-percentile-work_42024698 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42024698; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_42024698"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_42024698 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="42024698"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42024698; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42024698]").text(description); $(".js-view-count-work_42024698").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_42024698").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="42024698"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="35637" href="https://www.academia.edu/Documents/in/Molecular_Mechanics">Molecular Mechanics</a>, <script data-card-contents-for-ri="35637" type="text/json">{"id":35637,"name":"Molecular Mechanics","url":"https://www.academia.edu/Documents/in/Molecular_Mechanics","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="95266" href="https://www.academia.edu/Documents/in/Triple_Helix">Triple Helix</a>, <script data-card-contents-for-ri="95266" type="text/json">{"id":95266,"name":"Triple Helix","url":"https://www.academia.edu/Documents/in/Triple_Helix","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="541785" href="https://www.academia.edu/Documents/in/Phosphates">Phosphates</a>, <script data-card-contents-for-ri="541785" type="text/json">{"id":541785,"name":"Phosphates","url":"https://www.academia.edu/Documents/in/Phosphates","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="649537" href="https://www.academia.edu/Documents/in/Molecular_Conformation">Molecular Conformation</a><script data-card-contents-for-ri="649537" type="text/json">{"id":649537,"name":"Molecular Conformation","url":"https://www.academia.edu/Documents/in/Molecular_Conformation","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=42024698]'), work: {"id":42024698,"title":"Oligonucleotides Containing an Acridine Group Covalently Bonded to the Nucleotide Flanking the 3′-3′ Phosphodiester Junction for Alternate Strand Triple Helix Formation","created_at":"2020-02-20T03:27:05.642-08:00","owner_id":1110486,"url":"https://www.academia.edu/42024698/Oligonucleotides_Containing_an_Acridine_Group_Covalently_Bonded_to_the_Nucleotide_Flanking_the_3_3_Phosphodiester_Junction_for_Alternate_Strand_Triple_Helix_Formation","slug":"Oligonucleotides_Containing_an_Acridine_Group_Covalently_Bonded_to_the_Nucleotide_Flanking_the_3_3_Phosphodiester_Junction_for_Alternate_Strand_Triple_Helix_Formation","dom_id":"work_42024698","summary":null,"publication":"Nucleosides Nucleotides and Nucleic Acids","publication_with_fallback":"Nucleosides Nucleotides and Nucleic Acids","downloadable_attachments":[{"id":62149830,"asset_id":42024698,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149830/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149830/chin.20040618620200220-17573-1sfttrx-libre.pdf?1582199237=\u0026response-content-disposition=attachment%3B+filename%3DOligonucleotides_Containing_an_Acridine.pdf\u0026Expires=1733320514\u0026Signature=KiUkE4wpcqlc6Ik2oiqddRjFUnfTiA-4fdIJ6fJFfl-gF9VJ7h3YhiAEMNacqvwEjoWlItB7Pozu-xIhGd0-NIOY-OrKrjLhoGUT5~9bRWEUMeyuT4M7~gSOXAtjhFJtBCgQhGHGKd7NFXVAFXpBAYUfbXeWyrI1vFWV-YiX8oKYW~V6nxB6uD~AHo85jWfESHVU75jBtdW9U8e-vDLQhvI4zuZfhT~9pJmsRFd~oo4GNFhEA~50wwAldIt76ZiFYdvKbxity8r2FVn7Baxhz0G37KBeWbE~mA3dMwBiIEWf5Nw3ZbgZ6hSodOfiIWZK~RMH0~u4y2gq0nnw7-jcyw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149830/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149830/mini_magick20200220-17570-1g2crua.png?1582198340"}],"downloadable_attachments_with_full_thumbnails":[{"id":62149830,"asset_id":42024698,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/62149830/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/62149830/chin.20040618620200220-17573-1sfttrx-libre.pdf?1582199237=\u0026response-content-disposition=attachment%3B+filename%3DOligonucleotides_Containing_an_Acridine.pdf\u0026Expires=1733320514\u0026Signature=KiUkE4wpcqlc6Ik2oiqddRjFUnfTiA-4fdIJ6fJFfl-gF9VJ7h3YhiAEMNacqvwEjoWlItB7Pozu-xIhGd0-NIOY-OrKrjLhoGUT5~9bRWEUMeyuT4M7~gSOXAtjhFJtBCgQhGHGKd7NFXVAFXpBAYUfbXeWyrI1vFWV-YiX8oKYW~V6nxB6uD~AHo85jWfESHVU75jBtdW9U8e-vDLQhvI4zuZfhT~9pJmsRFd~oo4GNFhEA~50wwAldIt76ZiFYdvKbxity8r2FVn7Baxhz0G37KBeWbE~mA3dMwBiIEWf5Nw3ZbgZ6hSodOfiIWZK~RMH0~u4y2gq0nnw7-jcyw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/62149830/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/62149830/mini_magick20200220-17570-1g2crua.png?1582198340"}],"has_pdf":true,"has_fulltext":true,"page_count":1,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":35637,"name":"Molecular Mechanics","url":"https://www.academia.edu/Documents/in/Molecular_Mechanics","nofollow":false},{"id":95266,"name":"Triple Helix","url":"https://www.academia.edu/Documents/in/Triple_Helix","nofollow":false},{"id":541785,"name":"Phosphates","url":"https://www.academia.edu/Documents/in/Phosphates","nofollow":false},{"id":649537,"name":"Molecular Conformation","url":"https://www.academia.edu/Documents/in/Molecular_Conformation","nofollow":false},{"id":1362652,"name":"Nucleic Acid Conformation","url":"https://www.academia.edu/Documents/in/Nucleic_Acid_Conformation"},{"id":1597877,"name":"Nucleotides","url":"https://www.academia.edu/Documents/in/Nucleotides"},{"id":1649745,"name":"Oligonucleotides","url":"https://www.academia.edu/Documents/in/Oligonucleotides"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":2205703,"name":"Oligonucleotide","url":"https://www.academia.edu/Documents/in/Oligonucleotide"}],"publication_year":2006,"publication_year_with_fallback":2006,"paper_rank":null,"all_time_views":3,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_64708022" data-work_id="64708022" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/64708022/Exploring_the_fatty_acid_amide_hydrolase_and_cyclooxygenase_inhibitory_properties_of_novel_amide_derivatives_of_ibuprofen">Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/64708022" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6fee1fa225604fa9fe322cbdc75b1f3a" rel="nofollow" data-download="{"attachment_id":76620174,"asset_id":64708022,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76620174/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_64708022 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="64708022"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 64708022, container: ".js-paper-rank-work_64708022", }); });</script></li><li class="js-percentile-work_64708022 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 64708022; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_64708022"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_64708022 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="64708022"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 64708022; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=64708022]").text(description); $(".js-view-count-work_64708022").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_64708022").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="64708022"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="523" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1681026" href="https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology">Biochemistry and cell biology</a><script data-card-contents-for-ri="1681026" type="text/json">{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=64708022]'), work: {"id":64708022,"title":"Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen","created_at":"2021-12-16T22:46:57.489-08:00","owner_id":1110486,"url":"https://www.academia.edu/64708022/Exploring_the_fatty_acid_amide_hydrolase_and_cyclooxygenase_inhibitory_properties_of_novel_amide_derivatives_of_ibuprofen","slug":"Exploring_the_fatty_acid_amide_hydrolase_and_cyclooxygenase_inhibitory_properties_of_novel_amide_derivatives_of_ibuprofen","dom_id":"work_64708022","summary":null,"publication":"Journal of Enzyme Inhibition and Medicinal Chemistry","publication_with_fallback":"Journal of Enzyme Inhibition and Medicinal Chemistry","downloadable_attachments":[{"id":76620174,"asset_id":64708022,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/76620174/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/76620174/14756366.2020-libre.pdf?1639761230=\u0026response-content-disposition=attachment%3B+filename%3DExploring_the_fatty_acid_amide_hydrolase.pdf\u0026Expires=1733320514\u0026Signature=UFwrHIFa2It1VurVHlbkIqWQMpUz4FvcUKwX2qIl3KF~WSKtyP3l5BiggtpOKgbqOdQcgC7n~3JcZ8Be8~eZvVzpuD4teBr6BGHkzzoymXGpUnfoX~osn85OG9ObvAZy4~wU2nYXRu7tYOp4E5s3npzKgMAGVXf6EOZqk-Ehie-j51M6YMShg~0hT0Gzyvvt4Tu6l22I6OLvA8lehbSx3k7IuhaSQXKujiwwm7k~sV70CCBWkVKF7vfUt4hbIMRmLYPoKhtXk9AAbWSlvXaDFwdRS6G4a~Y7M9CbeWUXcfvxd8JGlm41UO5JaJXMFIayQnKpBu~0OKsW162cjkx0DA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/76620174/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/76620174/mini_magick20211216-19124-pipuwz.png?1639724270"}],"downloadable_attachments_with_full_thumbnails":[{"id":76620174,"asset_id":64708022,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/76620174/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/76620174/14756366.2020-libre.pdf?1639761230=\u0026response-content-disposition=attachment%3B+filename%3DExploring_the_fatty_acid_amide_hydrolase.pdf\u0026Expires=1733320514\u0026Signature=UFwrHIFa2It1VurVHlbkIqWQMpUz4FvcUKwX2qIl3KF~WSKtyP3l5BiggtpOKgbqOdQcgC7n~3JcZ8Be8~eZvVzpuD4teBr6BGHkzzoymXGpUnfoX~osn85OG9ObvAZy4~wU2nYXRu7tYOp4E5s3npzKgMAGVXf6EOZqk-Ehie-j51M6YMShg~0hT0Gzyvvt4Tu6l22I6OLvA8lehbSx3k7IuhaSQXKujiwwm7k~sV70CCBWkVKF7vfUt4hbIMRmLYPoKhtXk9AAbWSlvXaDFwdRS6G4a~Y7M9CbeWUXcfvxd8JGlm41UO5JaJXMFIayQnKpBu~0OKsW162cjkx0DA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/76620174/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/76620174/mini_magick20211216-19124-pipuwz.png?1639724270"}],"has_pdf":true,"has_fulltext":true,"page_count":10,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology","nofollow":false}],"publication_year":null,"publication_year_with_fallback":null,"paper_rank":null,"all_time_views":3,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_86455310" data-work_id="86455310" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/86455310/Synthesis_and_Biological_Evaluation_of_a_New_Structural_Simplified_Analogue_of_cADPR_a_Calcium_Mobilizing_Secondary_Messenger_Firstly_Isolated_from_Sea_Urchin_Eggs">Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/86455310" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="da77f8faf8eb1eaa2437ca40717dbeea" rel="nofollow" data-download="{"attachment_id":90904742,"asset_id":86455310,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/90904742/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_86455310 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="86455310"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 86455310, container: ".js-paper-rank-work_86455310", }); });</script></li><li class="js-percentile-work_86455310 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 86455310; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_86455310"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_86455310 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="86455310"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 86455310; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=86455310]").text(description); $(".js-view-count-work_86455310").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_86455310").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="86455310"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="523" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9534" href="https://www.academia.edu/Documents/in/Calcium">Calcium</a>, <script data-card-contents-for-ri="9534" type="text/json">{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="560354" href="https://www.academia.edu/Documents/in/Sea_Urchin">Sea Urchin</a><script data-card-contents-for-ri="560354" type="text/json">{"id":560354,"name":"Sea Urchin","url":"https://www.academia.edu/Documents/in/Sea_Urchin","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=86455310]'), work: {"id":86455310,"title":"Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs","created_at":"2022-09-11T07:31:29.341-07:00","owner_id":1110486,"url":"https://www.academia.edu/86455310/Synthesis_and_Biological_Evaluation_of_a_New_Structural_Simplified_Analogue_of_cADPR_a_Calcium_Mobilizing_Secondary_Messenger_Firstly_Isolated_from_Sea_Urchin_Eggs","slug":"Synthesis_and_Biological_Evaluation_of_a_New_Structural_Simplified_Analogue_of_cADPR_a_Calcium_Mobilizing_Secondary_Messenger_Firstly_Isolated_from_Sea_Urchin_Eggs","dom_id":"work_86455310","summary":null,"publication":"Marine Drugs","publication_with_fallback":"Marine Drugs","downloadable_attachments":[{"id":90904742,"asset_id":86455310,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/90904742/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/90904742/pdf-libre.pdf?1662910903=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_Biological_Evaluation_of_a.pdf\u0026Expires=1733320514\u0026Signature=Uan-1IwKeOor-YQxHXJAhmjyLeR5Av2gpvky1JQOgiL7zlZcDIfjpVuaccxPt70N2v81H2rECAgHmKvj7QzjOQlXp3R~n5VmtP6gX995VaZwqdLDCXuhGyUDt6VMc5wR~s-h3vNYdLpLaIoMN1KwEIkQpBaC6dYTZdT1k8bNt-urfZoKRYwpBSB~3Tgh8NqYoKAEhvHC5eM6bxSQNGk8agfpVpI1C9PlVGBvgheCBcWlZ1noVi~gGJ536qtM3-RaQ0zx9WXxiRSIDiOACD9nnwHtR1gMKqz0Wbhsty5L9ztXhuWRB4Yft0tIIulBDIflVFAqanUFA~XKYEx1FOLioA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/90904742/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/90904742/mini_magick20220911-1-14k3vik.png?1662911015"}],"downloadable_attachments_with_full_thumbnails":[{"id":90904742,"asset_id":86455310,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/90904742/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/90904742/pdf-libre.pdf?1662910903=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_Biological_Evaluation_of_a.pdf\u0026Expires=1733320514\u0026Signature=Uan-1IwKeOor-YQxHXJAhmjyLeR5Av2gpvky1JQOgiL7zlZcDIfjpVuaccxPt70N2v81H2rECAgHmKvj7QzjOQlXp3R~n5VmtP6gX995VaZwqdLDCXuhGyUDt6VMc5wR~s-h3vNYdLpLaIoMN1KwEIkQpBaC6dYTZdT1k8bNt-urfZoKRYwpBSB~3Tgh8NqYoKAEhvHC5eM6bxSQNGk8agfpVpI1C9PlVGBvgheCBcWlZ1noVi~gGJ536qtM3-RaQ0zx9WXxiRSIDiOACD9nnwHtR1gMKqz0Wbhsty5L9ztXhuWRB4Yft0tIIulBDIflVFAqanUFA~XKYEx1FOLioA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/90904742/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/90904742/mini_magick20220911-1-14k3vik.png?1662911015"}],"has_pdf":true,"has_fulltext":true,"page_count":14,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false},{"id":560354,"name":"Sea Urchin","url":"https://www.academia.edu/Documents/in/Sea_Urchin","nofollow":false},{"id":1448161,"name":"Marine Drugs","url":"https://www.academia.edu/Documents/in/Marine_Drugs"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"publication_year":2018,"publication_year_with_fallback":2018,"paper_rank":null,"all_time_views":2,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_88102760" data-work_id="88102760" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/88102760/Discovery_of_a_AhR_flavonoid_agonist_that_counter_regulates_ACE2_expression_in_rodent_models_of_inflammation_and_attenuates_ACE2_SARS_CoV2_interaction_in_vitro">Discovery of a AhR flavonoid agonist that counter-regulates ACE2 expression in rodent models of inflammation and attenuates ACE2-SARS-CoV2 interaction in vitro</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The severe acute respiratory syndrome (SARS)-CoV-2, a newly emerged coronavirus first identified in 2019, is the pathogenetic agent od Corona Virus Induced Disease (COVID)19. The virus enters the human cells after binding to the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_88102760" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The severe acute respiratory syndrome (SARS)-CoV-2, a newly emerged coronavirus first identified in 2019, is the pathogenetic agent od Corona Virus Induced Disease (COVID)19. The virus enters the human cells after binding to the angiotensin converting enzyme (ACE) 2 receptor in target tissues. ACE2 expression is induced in response to inflammation. The colon expression of ACE2 is upregulated in patients with inflammatory bowel disease (IBD), highlighting a potential risk of intestinal inflammation in promoting viral entry in the human body. Because mechanisms that regulate ACE2 expression in the intestine are poorly understood and there is a need of anti-SARS-CoV2 therapies, we have settled to investigate whether natural flavonoids might regulate the expression of ACE2 in intestinal models of inflammation. The results of these studies demonstrated that pelargonidin, a natural flavonoid bind and activates the Aryl hydrocarbon Receptor (AhR) in vitro and reverses intestinal inflammati...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/88102760" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b9cbf056af06780d671c98db3eaf6666" rel="nofollow" data-download="{"attachment_id":92144609,"asset_id":88102760,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/92144609/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_88102760 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="88102760"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 88102760, container: ".js-paper-rank-work_88102760", }); });</script></li><li class="js-percentile-work_88102760 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 88102760; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_88102760"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_88102760 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="88102760"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 88102760; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=88102760]").text(description); $(".js-view-count-work_88102760").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_88102760").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="88102760"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="9334" href="https://www.academia.edu/Documents/in/Inflammation">Inflammation</a>, <script data-card-contents-for-ri="9334" type="text/json">{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="238007" href="https://www.academia.edu/Documents/in/Aryl_Hydrocarbon_Receptor">Aryl Hydrocarbon Receptor</a>, <script data-card-contents-for-ri="238007" type="text/json">{"id":238007,"name":"Aryl Hydrocarbon Receptor","url":"https://www.academia.edu/Documents/in/Aryl_Hydrocarbon_Receptor","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="555007" href="https://www.academia.edu/Documents/in/Receptor">Receptor</a><script data-card-contents-for-ri="555007" type="text/json">{"id":555007,"name":"Receptor","url":"https://www.academia.edu/Documents/in/Receptor","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=88102760]'), work: {"id":88102760,"title":"Discovery of a AhR flavonoid agonist that counter-regulates ACE2 expression in rodent models of inflammation and attenuates ACE2-SARS-CoV2 interaction in vitro","created_at":"2022-10-08T01:00:37.700-07:00","owner_id":1110486,"url":"https://www.academia.edu/88102760/Discovery_of_a_AhR_flavonoid_agonist_that_counter_regulates_ACE2_expression_in_rodent_models_of_inflammation_and_attenuates_ACE2_SARS_CoV2_interaction_in_vitro","slug":"Discovery_of_a_AhR_flavonoid_agonist_that_counter_regulates_ACE2_expression_in_rodent_models_of_inflammation_and_attenuates_ACE2_SARS_CoV2_interaction_in_vitro","dom_id":"work_88102760","summary":"The severe acute respiratory syndrome (SARS)-CoV-2, a newly emerged coronavirus first identified in 2019, is the pathogenetic agent od Corona Virus Induced Disease (COVID)19. The virus enters the human cells after binding to the angiotensin converting enzyme (ACE) 2 receptor in target tissues. ACE2 expression is induced in response to inflammation. The colon expression of ACE2 is upregulated in patients with inflammatory bowel disease (IBD), highlighting a potential risk of intestinal inflammation in promoting viral entry in the human body. Because mechanisms that regulate ACE2 expression in the intestine are poorly understood and there is a need of anti-SARS-CoV2 therapies, we have settled to investigate whether natural flavonoids might regulate the expression of ACE2 in intestinal models of inflammation. The results of these studies demonstrated that pelargonidin, a natural flavonoid bind and activates the Aryl hydrocarbon Receptor (AhR) in vitro and reverses intestinal inflammati...","publication":null,"publication_with_fallback":"bioRxiv (Cold Spring Harbor Laboratory)","downloadable_attachments":[{"id":92144609,"asset_id":88102760,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/92144609/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/92144609/2021.02.24.432203.full-libre.pdf?1665218645=\u0026response-content-disposition=attachment%3B+filename%3DDiscovery_of_a_AhR_flavonoid_agonist_tha.pdf\u0026Expires=1733320514\u0026Signature=NkCVU6TaN5PbJ0cM0ATN0I35f1GJOwXAafWnZpPM5yCzR28KzeKn1gUoGiv0IN5VVBS~N7VJofbGZhCqmU~X0LRqXw5emf0PeZf9sqCUBqQrADXqVVX3bR0u8h8soK40rC72Nrb2Dvl9pQwy0YdN1qcpLmtniiocGXq2NSB~jx2lynueA1OGKbSwGq3ammRwwg88FPvOeJNVWQ-zl8pKnKlf3bj~YIDsU7yif19Ljc0Uy2omOveBYHyokp2-g7s~IJBnc6QDOhzFW68O4YAybHipHDuj34BPZ9kmRbpg4wsMN4u3Iez2P4S8zebLCB6n5YrV3zsKPuu7Oy4OjTdr9w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/92144609/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/92144609/mini_magick20221008-1-1cpicz0.png?1665216198"}],"downloadable_attachments_with_full_thumbnails":[{"id":92144609,"asset_id":88102760,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/92144609/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/92144609/2021.02.24.432203.full-libre.pdf?1665218645=\u0026response-content-disposition=attachment%3B+filename%3DDiscovery_of_a_AhR_flavonoid_agonist_tha.pdf\u0026Expires=1733320515\u0026Signature=ClDWRgwZ8p15Rpy7BDVBtEPXiXM7ZFOWyxmCwiQ2TROl4mfhuR6Qo7ilZ7uYDCMA-I5ftwxmqo7Hp4LCPweRoJkhYqKUqZ-PYk78jav6WMlTkUJvJHPdJ0Jh7pAP6cot68igXUfTIk6gBRJMSoa-ifn7QvVT0xGj6qpOKmSabNGMczceSnY8b0yxQIDHmMNi1lmUY8LP6OPXDNyu-nCyb~sZRZmJ7e8ifWkiHCyigcHEY1MqcVI43kAyPASqH9IE-A5CvK4BtpyHZt6UAnu9VfR-5gjZE3BvQHoo99A2Q50z~foAyR2ozDth-4cKdcK7hUQfEHrrmf~3ztpFOIe7KQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/92144609/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/92144609/mini_magick20221008-1-1cpicz0.png?1665216198"}],"has_pdf":true,"has_fulltext":true,"page_count":36,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation","nofollow":false},{"id":238007,"name":"Aryl Hydrocarbon Receptor","url":"https://www.academia.edu/Documents/in/Aryl_Hydrocarbon_Receptor","nofollow":false},{"id":555007,"name":"Receptor","url":"https://www.academia.edu/Documents/in/Receptor","nofollow":false}],"publication_year":2021,"publication_year_with_fallback":2021,"paper_rank":null,"all_time_views":2,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_88102821" data-work_id="88102821" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/88102821/Development_of_piperazine_tethered_heterodimers_as_potent_antimalarials_against_chloroquine_resistant_P_falciparum_strains_Synthesis_and_molecular_modeling">Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/88102821" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1886cb0f3d3d28426a74b436a3aa2536" rel="nofollow" data-download="{"attachment_id":92144682,"asset_id":88102821,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/92144682/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_88102821 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="88102821"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 88102821, container: ".js-paper-rank-work_88102821", }); });</script></li><li class="js-percentile-work_88102821 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 88102821; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_88102821"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_88102821 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="88102821"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 88102821; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=88102821]").text(description); $(".js-view-count-work_88102821").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_88102821").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="88102821"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="523" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="531" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="32927" href="https://www.academia.edu/Documents/in/Molecular_modeling">Molecular modeling</a><script data-card-contents-for-ri="32927" type="text/json">{"id":32927,"name":"Molecular modeling","url":"https://www.academia.edu/Documents/in/Molecular_modeling","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=88102821]'), work: {"id":88102821,"title":"Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling","created_at":"2022-10-08T01:01:28.613-07:00","owner_id":1110486,"url":"https://www.academia.edu/88102821/Development_of_piperazine_tethered_heterodimers_as_potent_antimalarials_against_chloroquine_resistant_P_falciparum_strains_Synthesis_and_molecular_modeling","slug":"Development_of_piperazine_tethered_heterodimers_as_potent_antimalarials_against_chloroquine_resistant_P_falciparum_strains_Synthesis_and_molecular_modeling","dom_id":"work_88102821","summary":null,"publication":"Bioorganic \u0026 Medicinal Chemistry Letters","publication_with_fallback":"Bioorganic \u0026 Medicinal Chemistry Letters","downloadable_attachments":[{"id":92144682,"asset_id":88102821,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/92144682/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/92144682/j.bmcl.2007.04.07720221008-1-vge0vb-libre.pdf?1665218640=\u0026response-content-disposition=attachment%3B+filename%3DDevelopment_of_piperazine_tethered_heter.pdf\u0026Expires=1733320515\u0026Signature=X5~neiucsZQ091JTC6bd7Y8lKIJE48EiW0KpghgRpFVO3vWrGC2YsDf7Qj-PbzYnQ~Pez8wZhbVs2-l6qX2lRxSZkwpWshgV12hP4vM38wydRsBkxEGdYDjTPjdN5OS4MbqFgMwngImN5ZLV9AcMNatqgLfcuzZ-SaksWzC04sJAg7mk7RrzYzNoALknyjpuec84JJa~L6-Z8dcBvdMlzNOUodJgKrutk7lXC6128rQ17LSGFbGJyIfWfMIPIBRzS~7l1EqIyhhH~HSkPB7OvAr2qRZVHX-eCpU1h~rNVz8DH1QYGkwYGZbcJKOd-LdKVdv78D9QV2IghnDrcYRpyg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/92144682/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/92144682/mini_magick20221008-1-xmhqgl.png?1665216236"}],"downloadable_attachments_with_full_thumbnails":[{"id":92144682,"asset_id":88102821,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/92144682/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/92144682/j.bmcl.2007.04.07720221008-1-vge0vb-libre.pdf?1665218640=\u0026response-content-disposition=attachment%3B+filename%3DDevelopment_of_piperazine_tethered_heter.pdf\u0026Expires=1733320515\u0026Signature=X5~neiucsZQ091JTC6bd7Y8lKIJE48EiW0KpghgRpFVO3vWrGC2YsDf7Qj-PbzYnQ~Pez8wZhbVs2-l6qX2lRxSZkwpWshgV12hP4vM38wydRsBkxEGdYDjTPjdN5OS4MbqFgMwngImN5ZLV9AcMNatqgLfcuzZ-SaksWzC04sJAg7mk7RrzYzNoALknyjpuec84JJa~L6-Z8dcBvdMlzNOUodJgKrutk7lXC6128rQ17LSGFbGJyIfWfMIPIBRzS~7l1EqIyhhH~HSkPB7OvAr2qRZVHX-eCpU1h~rNVz8DH1QYGkwYGZbcJKOd-LdKVdv78D9QV2IghnDrcYRpyg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/92144682/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/92144682/mini_magick20221008-1-xmhqgl.png?1665216236"}],"has_pdf":true,"has_fulltext":true,"page_count":5,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false},{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false},{"id":32927,"name":"Molecular modeling","url":"https://www.academia.edu/Documents/in/Molecular_modeling","nofollow":false},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro"},{"id":102583,"name":"Drug Resistance","url":"https://www.academia.edu/Documents/in/Drug_Resistance"},{"id":120789,"name":"Drug Design","url":"https://www.academia.edu/Documents/in/Drug_Design"},{"id":158597,"name":"Iron","url":"https://www.academia.edu/Documents/in/Iron"},{"id":255058,"name":"Metals","url":"https://www.academia.edu/Documents/in/Metals"},{"id":454707,"name":"Antimalarials","url":"https://www.academia.edu/Documents/in/Antimalarials"},{"id":590943,"name":"Metal ion","url":"https://www.academia.edu/Documents/in/Metal_ion"},{"id":649537,"name":"Molecular Conformation","url":"https://www.academia.edu/Documents/in/Molecular_Conformation"},{"id":728493,"name":"Bioorganic and medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Bioorganic_and_medicinal_Chemistry"},{"id":919274,"name":"Chloroquine","url":"https://www.academia.edu/Documents/in/Chloroquine"},{"id":1257974,"name":"Ions","url":"https://www.academia.edu/Documents/in/Ions"},{"id":1809037,"name":"Dimerization","url":"https://www.academia.edu/Documents/in/Dimerization"},{"id":2095314,"name":"Linker","url":"https://www.academia.edu/Documents/in/Linker"},{"id":2106543,"name":"Clotrimazole Uk","url":"https://www.academia.edu/Documents/in/Clotrimazole_Uk"},{"id":2356820,"name":"Clotrimazole","url":"https://www.academia.edu/Documents/in/Clotrimazole"}],"publication_year":2007,"publication_year_with_fallback":2007,"paper_rank":null,"all_time_views":2,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_88102824" data-work_id="88102824" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/88102824/Specific_Targeting_Highly_Conserved_Residues_in_the_HIV_1_Reverse_Transcriptase_Primer_Grip_Region_Design_Synthesis_and_Biological_Evaluation_of_Novel_Potent_and_Broad_Spectrum_NNRTIs_with_Antiviral_Activity">Specific Targeting Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. Design, Synthesis, and Biological Evaluation of Novel, Potent, and Broad Spectrum NNRTIs with Antiviral Activity</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/88102824" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="54ef4ec88991955819075a6bd906814c" rel="nofollow" data-download="{"attachment_id":92144681,"asset_id":88102824,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/92144681/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_88102824 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="88102824"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 88102824, container: ".js-paper-rank-work_88102824", }); });</script></li><li class="js-percentile-work_88102824 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 88102824; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_88102824"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_88102824 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="88102824"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 88102824; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=88102824]").text(description); $(".js-view-count-work_88102824").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_88102824").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="88102824"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="523" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="531" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2375" href="https://www.academia.edu/Documents/in/Medicinal_Chemistry">Medicinal Chemistry</a>, <script data-card-contents-for-ri="2375" type="text/json">{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="17491" href="https://www.academia.edu/Documents/in/Macrophages">Macrophages</a><script data-card-contents-for-ri="17491" type="text/json">{"id":17491,"name":"Macrophages","url":"https://www.academia.edu/Documents/in/Macrophages","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=88102824]'), work: {"id":88102824,"title":"Specific Targeting Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. Design, Synthesis, and Biological Evaluation of Novel, Potent, and Broad Spectrum NNRTIs with Antiviral Activity","created_at":"2022-10-08T01:01:31.549-07:00","owner_id":1110486,"url":"https://www.academia.edu/88102824/Specific_Targeting_Highly_Conserved_Residues_in_the_HIV_1_Reverse_Transcriptase_Primer_Grip_Region_Design_Synthesis_and_Biological_Evaluation_of_Novel_Potent_and_Broad_Spectrum_NNRTIs_with_Antiviral_Activity","slug":"Specific_Targeting_Highly_Conserved_Residues_in_the_HIV_1_Reverse_Transcriptase_Primer_Grip_Region_Design_Synthesis_and_Biological_Evaluation_of_Novel_Potent_and_Broad_Spectrum_NNRTIs_with_Antiviral_Activity","dom_id":"work_88102824","summary":null,"publication":"Journal of Medicinal Chemistry","publication_with_fallback":"Journal of Medicinal Chemistry","downloadable_attachments":[{"id":92144681,"asset_id":88102824,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/92144681/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/92144681/JMedChem2005-libre.pdf?1665218642=\u0026response-content-disposition=attachment%3B+filename%3DSpecific_Targeting_Highly_Conserved_Resi.pdf\u0026Expires=1733320515\u0026Signature=VILe~vh35y-2rljOPNKtowbnMIZnA0c6CQ3TJj2ZRAYpdDrswnFLXzmCXxfWg-yDqed4oqHJ1sYovTmktfkdxuaeALQU359SSUFHCypwOlfnnsW6GPqaCG-H8AWjv1T~-8epGaWsiZ0JEJ7T9Ziz5kJevpx17EUTfXCiMJkyQtuCR0569hLombu3rJyf4iqYLr3a3Mmd9usg5p0y06yIIPEhc1~uWNWs9M9D990OpKpeTE2PfrOwaj8JfY6eIbDbPHOF2pUTAdyZs783nCUh1e-az0SK1ylOQsKSx4T3eBVmmSXnIvDpuDrMmN2n8PP1-VQ2kSskKQ5L2YFxn78gdA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/92144681/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/92144681/mini_magick20221008-1-31ist3.png?1665216250"}],"downloadable_attachments_with_full_thumbnails":[{"id":92144681,"asset_id":88102824,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/92144681/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/92144681/JMedChem2005-libre.pdf?1665218642=\u0026response-content-disposition=attachment%3B+filename%3DSpecific_Targeting_Highly_Conserved_Resi.pdf\u0026Expires=1733320515\u0026Signature=VILe~vh35y-2rljOPNKtowbnMIZnA0c6CQ3TJj2ZRAYpdDrswnFLXzmCXxfWg-yDqed4oqHJ1sYovTmktfkdxuaeALQU359SSUFHCypwOlfnnsW6GPqaCG-H8AWjv1T~-8epGaWsiZ0JEJ7T9Ziz5kJevpx17EUTfXCiMJkyQtuCR0569hLombu3rJyf4iqYLr3a3Mmd9usg5p0y06yIIPEhc1~uWNWs9M9D990OpKpeTE2PfrOwaj8JfY6eIbDbPHOF2pUTAdyZs783nCUh1e-az0SK1ylOQsKSx4T3eBVmmSXnIvDpuDrMmN2n8PP1-VQ2kSskKQ5L2YFxn78gdA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/92144681/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/92144681/mini_magick20221008-1-31ist3.png?1665216250"}],"has_pdf":true,"has_fulltext":true,"page_count":13,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false},{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false},{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry","nofollow":false},{"id":17491,"name":"Macrophages","url":"https://www.academia.edu/Documents/in/Macrophages","nofollow":false},{"id":39978,"name":"HIV","url":"https://www.academia.edu/Documents/in/HIV"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":120789,"name":"Drug Design","url":"https://www.academia.edu/Documents/in/Drug_Design"},{"id":321836,"name":"Spectrum","url":"https://www.academia.edu/Documents/in/Spectrum"},{"id":446162,"name":"Medicinal","url":"https://www.academia.edu/Documents/in/Medicinal"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence"},{"id":902999,"name":"Antiviral Activity","url":"https://www.academia.edu/Documents/in/Antiviral_Activity"},{"id":973494,"name":"Reverse Transcriptase","url":"https://www.academia.edu/Documents/in/Reverse_Transcriptase"},{"id":2898895,"name":"binding sites","url":"https://www.academia.edu/Documents/in/binding_sites"},{"id":3545627,"name":"Drug synergism","url":"https://www.academia.edu/Documents/in/Drug_synergism"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"},{"id":3853201,"name":"reverse transcriptase inhibitors","url":"https://www.academia.edu/Documents/in/reverse_transcriptase_inhibitors"},{"id":3889175,"name":"stereoisomerism","url":"https://www.academia.edu/Documents/in/stereoisomerism"}],"publication_year":2005,"publication_year_with_fallback":2005,"paper_rank":null,"all_time_views":2,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_88102831" data-work_id="88102831" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/88102831/Peptide_Nucleic_Acids_as_miRNA_Target_Protectors_for_the_Treatment_of_Cystic_Fibrosis">Peptide Nucleic Acids as miRNA Target Protectors for the Treatment of Cystic Fibrosis</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/88102831" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="20fb429f69131379283410804fb765a8" rel="nofollow" data-download="{"attachment_id":92144607,"asset_id":88102831,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/92144607/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1110486" href="https://unina.academia.edu/BrunoCatalanotti">Bruno Catalanotti</a><script data-card-contents-for-user="1110486" type="text/json">{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_88102831 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="88102831"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 88102831, container: ".js-paper-rank-work_88102831", }); });</script></li><li class="js-percentile-work_88102831 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 88102831; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_88102831"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_88102831 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="88102831"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 88102831; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=88102831]").text(description); $(".js-view-count-work_88102831").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_88102831").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="88102831"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="531" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5490" href="https://www.academia.edu/Documents/in/MicroRNA">MicroRNA</a>, <script data-card-contents-for-ri="5490" type="text/json">{"id":5490,"name":"MicroRNA","url":"https://www.academia.edu/Documents/in/MicroRNA","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6946" href="https://www.academia.edu/Documents/in/Cystic_Fibrosis">Cystic Fibrosis</a>, <script data-card-contents-for-ri="6946" type="text/json">{"id":6946,"name":"Cystic Fibrosis","url":"https://www.academia.edu/Documents/in/Cystic_Fibrosis","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a><script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=88102831]'), work: {"id":88102831,"title":"Peptide Nucleic Acids as miRNA Target Protectors for the Treatment of Cystic Fibrosis","created_at":"2022-10-08T01:01:35.791-07:00","owner_id":1110486,"url":"https://www.academia.edu/88102831/Peptide_Nucleic_Acids_as_miRNA_Target_Protectors_for_the_Treatment_of_Cystic_Fibrosis","slug":"Peptide_Nucleic_Acids_as_miRNA_Target_Protectors_for_the_Treatment_of_Cystic_Fibrosis","dom_id":"work_88102831","summary":null,"publication":"Molecules","publication_with_fallback":"Molecules","downloadable_attachments":[{"id":92144607,"asset_id":88102831,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/92144607/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/92144607/pdf-libre.pdf?1665218651=\u0026response-content-disposition=attachment%3B+filename%3DPeptide_Nucleic_Acids_as_miRNA_Target_Pr.pdf\u0026Expires=1733320515\u0026Signature=KfxmrcwTxsSNh97Z1-9lONr-tusrVLBwW~ibDT2vSvXfE1EU~JzHMK58I-NBkaptRc72yAQHRQtTSuxEtNBfe5pGPKkRzsvXqoJzphx-rhguSCbpD1l5azC3wl4NP5T0AXkxXidRBRo1XJ0mXcFCCZl9I1hLemKoX6HO9iRZlxLNyZoZ3LzG3hY-n4Zy8-SsSStxxWqLFoVQ36LJ0dUvgCahpNph~rJSPUhBPSGtIjFCR0Zeym4L6tCvRDPU8B0lpLMSp236i5ZWxleSuFQUF4je9Ku8nDtqk13Wj6BO6Ot1jFoiphOf9YbSFjxLnA61mEQAP38iuvTIrDGeEVEeoQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/92144607/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/92144607/mini_magick20221008-1-1wxp1hb.png?1665216172"}],"downloadable_attachments_with_full_thumbnails":[{"id":92144607,"asset_id":88102831,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/92144607/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/92144607/pdf-libre.pdf?1665218651=\u0026response-content-disposition=attachment%3B+filename%3DPeptide_Nucleic_Acids_as_miRNA_Target_Pr.pdf\u0026Expires=1733320515\u0026Signature=KfxmrcwTxsSNh97Z1-9lONr-tusrVLBwW~ibDT2vSvXfE1EU~JzHMK58I-NBkaptRc72yAQHRQtTSuxEtNBfe5pGPKkRzsvXqoJzphx-rhguSCbpD1l5azC3wl4NP5T0AXkxXidRBRo1XJ0mXcFCCZl9I1hLemKoX6HO9iRZlxLNyZoZ3LzG3hY-n4Zy8-SsSStxxWqLFoVQ36LJ0dUvgCahpNph~rJSPUhBPSGtIjFCR0Zeym4L6tCvRDPU8B0lpLMSp236i5ZWxleSuFQUF4je9Ku8nDtqk13Wj6BO6Ot1jFoiphOf9YbSFjxLnA61mEQAP38iuvTIrDGeEVEeoQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/92144607/download_file?st=MTczMzM0Nzg2OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/92144607/mini_magick20221008-1-1wxp1hb.png?1665216172"}],"has_pdf":true,"has_fulltext":true,"page_count":16,"ordered_authors":[{"id":1110486,"first_name":"Bruno","last_name":"Catalanotti","domain_name":"unina","page_name":"BrunoCatalanotti","display_name":"Bruno Catalanotti","profile_url":"https://unina.academia.edu/BrunoCatalanotti","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry","nofollow":false},{"id":5490,"name":"MicroRNA","url":"https://www.academia.edu/Documents/in/MicroRNA","nofollow":false},{"id":6946,"name":"Cystic Fibrosis","url":"https://www.academia.edu/Documents/in/Cystic_Fibrosis","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation"},{"id":111973,"name":"Peptide Nucleic Acids","url":"https://www.academia.edu/Documents/in/Peptide_Nucleic_Acids"},{"id":295854,"name":"microRNAs","url":"https://www.academia.edu/Documents/in/microRNAs"},{"id":328449,"name":"Molecules","url":"https://www.academia.edu/Documents/in/Molecules"},{"id":620070,"name":"Transfection","url":"https://www.academia.edu/Documents/in/Transfection"},{"id":1727314,"name":"Nucleic Acid","url":"https://www.academia.edu/Documents/in/Nucleic_Acid"}],"publication_year":2017,"publication_year_with_fallback":2017,"paper_rank":null,"all_time_views":3,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div></div></div><div class="u-taCenter Pagination"><ul class="pagination "> <li class="page active"> <a href="/Departments/Chimica_delle_Sostanze_Naturali/Documents">1</a> </li> <li class="page"> <a rel="next" href="/Departments/Chimica_delle_Sostanze_Naturali/Documents?page=2">2</a> </li> <li class="page"> <a href="/Departments/Chimica_delle_Sostanze_Naturali/Documents?page=3">3</a> </li> <li class="page"> <a href="/Departments/Chimica_delle_Sostanze_Naturali/Documents?page=4">4</a> </li> <li class="next_page"> <a rel="next" href="/Departments/Chimica_delle_Sostanze_Naturali/Documents?page=2">Next &rsaquo;</a> </li> <li class="last next"> <a href="/Departments/Chimica_delle_Sostanze_Naturali/Documents?page=4">Last »</a> </li> </ul> </div></div></div></div></div></div></div> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "e4c498ba4fd307dce48008602b3c9776733118ba8ca1b3572316ba8fce059405", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="QZtl4oMxZ1uodFsfl5cttiJY4vbHp96gRWQFsWLaCeJ4lSIsGkPyy/otvDBfFyNCI+DwU0BH3Rf8HmiW27gN9Q==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://unina.academia.edu/Departments/Chimica_delle_Sostanze_Naturali/Documents" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="pQLGVZWYgwAbLEXhgJdfkd3UcbUbcKQYFZT+t0C/i7+cDIGbDOoWkEl1os5IF1Fl3GxjEJyQp6+s7pOQ+d2PqA==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style=""><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style=""><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>