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Branchial cleft cyst - Wikipedia

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cyst</a>)</span></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Branchial cyst</th></tr><tr><th scope="row" class="infobox-label">Other names</th><td class="infobox-data">Branchial arch fistula<br />Benign cervical lymphoepithelial cyst<br />Pharyngeal arch cyst</td></tr><tr style="background-color: #f8f9fa;"><td colspan="2" class="infobox-full-data"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Bilateral_Branchial_Cleft_Sinus_fistulography_right.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/72/Bilateral_Branchial_Cleft_Sinus_fistulography_right.jpg/220px-Bilateral_Branchial_Cleft_Sinus_fistulography_right.jpg" decoding="async" width="220" height="179" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/72/Bilateral_Branchial_Cleft_Sinus_fistulography_right.jpg/330px-Bilateral_Branchial_Cleft_Sinus_fistulography_right.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/72/Bilateral_Branchial_Cleft_Sinus_fistulography_right.jpg/440px-Bilateral_Branchial_Cleft_Sinus_fistulography_right.jpg 2x" data-file-width="1093" data-file-height="887" /></a></span></td></tr><tr><td colspan="2" class="infobox-full-data">Fistulogram (sinogram) of a right branchial cleft sinus.</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Medical_genetics" title="Medical genetics">Medical genetics</a>&#160;<span class="penicon autoconfirmed-show"><span class="mw-valign-text-top" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q2246002?uselang=en#P1995" title="Edit this on Wikidata"><img alt="Edit this on Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Signs_and_symptoms" title="Signs and symptoms">Symptoms</a></th><td class="infobox-data">Painless, firm mass lateral to midline, usually anterior to the <a href="/wiki/Sternocleidomastoid_muscle" title="Sternocleidomastoid muscle">SCM</a>, which does not move with swallowing</td></tr><tr><th scope="row" class="infobox-label">Causes</th><td class="infobox-data">Family history</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Differential_diagnosis" title="Differential diagnosis">Differential diagnosis</a></th><td class="infobox-data"><a href="/wiki/Vascular_anomaly" title="Vascular anomaly">Vascular anomaly</a>, <a href="/wiki/Dermoid_cyst" title="Dermoid cyst">dermoid cyst</a>, <a href="/wiki/Thymus#Cervical_thymic_cyst" title="Thymus">thymic cyst</a>, <a href="/wiki/Lymphadenopathy" title="Lymphadenopathy">lymphadenopathy</a>, <a href="/wiki/Lymphoma" title="Lymphoma">lymphoma</a>, <a href="/wiki/HPV-related_oropharyngeal_cancer" class="mw-redirect" title="HPV-related oropharyngeal cancer">HPV-related oropharyngeal cancer</a></td></tr><tr><th scope="row" class="infobox-label">Treatment</th><td class="infobox-data">Conservative, <a href="/wiki/Surgical_excision" class="mw-redirect" title="Surgical excision">surgical excision</a></td></tr></tbody></table> <p>A <b>branchial cleft cyst</b> or simply <b>branchial cyst</b> is a <a href="/wiki/Cyst" title="Cyst">cyst</a> as a swelling in the upper part of neck anterior to <a href="/wiki/Sternocleidomastoid" class="mw-redirect" title="Sternocleidomastoid">sternocleidomastoid</a>. It can, but does not necessarily, have an opening to the skin surface, called a <a href="/wiki/Fistula" title="Fistula">fistula</a>. The cause is usually a <a href="/wiki/Developmental_abnormality" class="mw-redirect" title="Developmental abnormality">developmental abnormality</a> arising in the early prenatal period, typically failure of obliteration of the second, third, and fourth <a href="/wiki/Pharyngeal_groove" title="Pharyngeal groove">branchial cleft</a>, i.e. failure of fusion of the second <a href="/wiki/Pharyngeal_arch" title="Pharyngeal arch">branchial arches</a> and epicardial ridge in lower part of the neck. Branchial cleft cysts account for almost 20% of neck masses in children.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Less commonly, the cysts can develop from the first, third, or fourth clefts, and their location and the location of associated fistulas differs accordingly. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Symptoms_and_signs">Symptoms and signs</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Branchial_cleft_cyst&amp;action=edit&amp;section=1" title="Edit section: Symptoms and signs"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Most branchial cleft cysts present in late childhood or early adulthood as a solitary, painless mass, which went previously unnoticed, that has now become <a href="/wiki/Infection" title="Infection">infected</a> (typically after an <a href="/wiki/Upper_respiratory_tract_infection" title="Upper respiratory tract infection">upper respiratory tract infection</a>). Fistulas, if present, are <a href="/wiki/Asymptomatic" title="Asymptomatic">asymptomatic</a> until infection arises.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pathophysiology">Pathophysiology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Branchial_cleft_cyst&amp;action=edit&amp;section=2" title="Edit section: Pathophysiology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:PharyngealArchHuman.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/56/PharyngealArchHuman.jpg/220px-PharyngealArchHuman.jpg" decoding="async" width="220" height="233" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/56/PharyngealArchHuman.jpg/330px-PharyngealArchHuman.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/56/PharyngealArchHuman.jpg/440px-PharyngealArchHuman.jpg 2x" data-file-width="600" data-file-height="636" /></a><figcaption>The <a href="/wiki/Pharyngeal_arches" class="mw-redirect" title="Pharyngeal arches">pharyngeal arches</a> as seen during <a href="/wiki/Embryonic_development" class="mw-redirect" title="Embryonic development">embryonic development</a></figcaption></figure> <p>Branchial cleft cysts are remnants of <a href="/wiki/Embryonic_development" class="mw-redirect" title="Embryonic development">embryonic development</a> and result from a failure of obliteration of one of the branchial clefts, which are <a href="/wiki/Homology_(biology)" title="Homology (biology)">homologous</a> to the structures in <a href="/wiki/Fish" title="Fish">fish</a> that develop into <a href="/wiki/Gills" class="mw-redirect" title="Gills">gills</a>.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Pathology">Pathology</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Branchial_cleft_cyst&amp;action=edit&amp;section=3" title="Edit section: Pathology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The cyst wall is composed of squamous <a href="/wiki/Epithelium" title="Epithelium">epithelium</a> (90%), columnar cells with or without <a href="/wiki/Cilium" title="Cilium">cilia</a>, or a mixture of both, with lymphoid infiltrate, often with prominent <a href="/wiki/Germinal_center" title="Germinal center">germinal centers</a> and few subcapsular lymph sinuses. The cyst is typically surrounded by lymphoid tissue that has attenuated or absent overlying epithelium due to inflammatory changes.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Branchial_cleft_cyst&amp;action=edit&amp;section=4" title="Edit section: Diagnosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <a href="/wiki/Diagnosis" title="Diagnosis">diagnosis</a> of branchial cleft cysts is typically done clinically due to their relatively consistent location in the neck, typically anterior to the <a href="/wiki/Sternocleidomastoid_muscle" title="Sternocleidomastoid muscle">sternocleidomastoid muscle</a>. For masses presenting in <a href="/wiki/Adult" title="Adult">adulthood</a>, the presumption should be a <a href="/wiki/Malignancy" title="Malignancy">malignancy</a> until proven otherwise, since carcinomas of the tonsil, tongue base and thyroid may all present as cystic masses of the neck.<sup id="cite_ref-:1_6-0" class="reference"><a href="#cite_note-:1-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> Unlike a thyroglossal duct cyst, when swallowing, the mass should not move up or down.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Types">Types</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Branchial_cleft_cyst&amp;action=edit&amp;section=5" title="Edit section: Types"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Bilateral_Branchial_Cleft_Sinus_intraoperative.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7b/Bilateral_Branchial_Cleft_Sinus_intraoperative.jpg/220px-Bilateral_Branchial_Cleft_Sinus_intraoperative.jpg" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7b/Bilateral_Branchial_Cleft_Sinus_intraoperative.jpg/330px-Bilateral_Branchial_Cleft_Sinus_intraoperative.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7b/Bilateral_Branchial_Cleft_Sinus_intraoperative.jpg/440px-Bilateral_Branchial_Cleft_Sinus_intraoperative.jpg 2x" data-file-width="2592" data-file-height="1944" /></a><figcaption>Bilateral branchial cleft sinuses during surgery.</figcaption></figure><p>Four branchial clefts (also called "grooves") form during the development of a human embryo. The first cleft normally develops into the <a href="/wiki/External_Auditory_Canal" class="mw-redirect" title="External Auditory Canal">external auditory canal</a>,<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup> but the remaining three arches are obliterated and have no persistent structures in normal development. Persistence or abnormal formation of these four clefts can all result in branchial cleft cysts which may or may not drain via sinus tracts. </p><ul><li>First branchial cleft cysts - These are also known as periauricular because of their position near the ear. They are always in or adjacent to the <a href="/wiki/Parotid_gland" title="Parotid gland">parotid gland</a>. These account for 8% of the sinuses and cysts of the neck. They are lateral to the <a href="/wiki/Facial_nerve" title="Facial nerve">facial nerve</a> and run parallel to the external auditory canal.<sup id="cite_ref-Quintanilla_2018_9-0" class="reference"><a href="#cite_note-Quintanilla_2018-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup></li> <li>Second branchial cleft cysts - These account for 90 to 95% of the neck cysts. Anterior to sternocleidomastoid muscle, posterior to <a href="/wiki/Submandibular_gland" title="Submandibular gland">submandibular gland</a>, lateral to carotid sheath. They are medial to the facial nerve at the anterior neck and above the hyoid bone. Skin pit can be found in this location. However, if skin pits are found on both sides of the neck, then, <a href="/wiki/Branchio-oto-renal_syndrome" title="Branchio-oto-renal syndrome">branchio-oto-renal syndrome</a> should be ruled out. Infection of the cysts in this region can compress <a href="/wiki/Trachea" title="Trachea">trachea</a>, causing respiratory problems, or it can compress the <a href="/wiki/Oesophagus" class="mw-redirect" title="Oesophagus">oesophagus</a>, causing <a href="/wiki/Dysphagia" title="Dysphagia">dysphagia</a>, and irritating the sternocleidomastoid muscle, causing <a href="/wiki/Torticollis" title="Torticollis">torticollis</a>.<sup id="cite_ref-Quintanilla_2018_9-1" class="reference"><a href="#cite_note-Quintanilla_2018-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup></li> <li>Third branchial cleft cysts - These are rare and located in the posterior triangle of the upper neck or the anterior triangle in the lower neck.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">&#91;</span>10<span class="cite-bracket">&#93;</span></a></sup></li> <li>Fourth branchial cleft abnormalities are not technically cysts, and so are referred to as branchial arch anomalies. They consist of a sinus tract or fistula extending from apex of pyriform sinus to anterior lower neck, usually adjacent to left thyroid lobe. If infected, they can cause <a href="/wiki/Acute_infectious_thyroiditis" title="Acute infectious thyroiditis">acute infectious thyroiditis</a> in children and if enlarge rapidly, can cause tracheal compression in children.<sup id="cite_ref-Quintanilla_2018_9-2" class="reference"><a href="#cite_note-Quintanilla_2018-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Branchial_cleft_cyst&amp;action=edit&amp;section=6" title="Edit section: Treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Conservative (i.e. no treatment), or <a href="/wiki/Surgical_excision" class="mw-redirect" title="Surgical excision">surgical excision</a>. With surgical excision, recurrence is common, usually due to incomplete excision. Often, the tracts of the cyst will pass near important structures, such as the <a href="/wiki/Internal_jugular_vein" title="Internal jugular vein">internal jugular vein</a>, <a href="/wiki/Common_carotid_artery" title="Common carotid artery">carotid artery</a>, or <a href="/wiki/Facial_nerve" title="Facial nerve">facial nerve</a>, making complete excision impractical due to the high risk of complications.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">&#91;</span>11<span class="cite-bracket">&#93;</span></a></sup> </p><p>An alternative and less invasive treatment is ultrasound-guided <a href="/wiki/Sclerotherapy" title="Sclerotherapy">sclerotherapy</a>.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">&#91;</span>12<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Branchial_cleft_cyst&amp;action=edit&amp;section=7" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Cutaneous_columnar_cyst" title="Cutaneous columnar cyst">Cutaneous columnar cyst</a></li> <li><a href="/wiki/Cystic_hygroma" title="Cystic hygroma">Cystic hygroma</a></li> <li><a href="/wiki/Gingival_cyst" title="Gingival cyst">Gingival cyst</a></li> <li><a href="/wiki/Mucocele" title="Mucocele">Mucocele</a></li> <li><a href="/wiki/Ranula" title="Ranula">Ranula</a></li> <li><a href="/wiki/Thyroglossal_duct_cyst" class="mw-redirect" title="Thyroglossal duct cyst">Thyroglossal duct cyst</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Branchial_cleft_cyst&amp;action=edit&amp;section=8" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFPincus2001" class="citation journal cs1">Pincus RL (2001). "Congenital neck masses and cysts". <i>Head &amp; Neck Surgery - Otolaryngology</i> (3&#160;ed.). 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<i>Ultrasonography</i>. <b>33</b> (2): 83–90. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.14366%2Fusg.13026">10.14366/usg.13026</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058977">4058977</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24936500">24936500</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Ultrasonography&amp;rft.atitle=Ultrasound-guided+sclerotherapy+for+benign+non-thyroid+cystic+mass+in+the+neck&amp;rft.volume=33&amp;rft.issue=2&amp;rft.pages=83-90&amp;rft.date=2014-04&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4058977%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F24936500&amp;rft_id=info%3Adoi%2F10.14366%2Fusg.13026&amp;rft.aulast=Kim&amp;rft.aufirst=J&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4058977&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3ABranchial+cleft+cyst" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Branchial_cleft_cyst&amp;action=edit&amp;section=9" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://www.ghorayeb.com/BranchialCleft.html">Pictures and Imaging of Branchial Cleft Cysts</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox,.mw-parser-output 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margin:0.5em 0 0.5em 0;;padding:3px"><table class="nowraplinks navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q2246002" class="extiw" title="d:Q2246002">D</a></div><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/ICD-10" title="ICD-10">10</a></b>: Q18.0 (<a href="/wiki/ILDS" class="mw-redirect" title="ILDS">ILDS</a> Q18.020)</li><li><b><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></b>: <a rel="nofollow" class="external text" href="https://omim.org/entry/113600">113600</a></li><li><b><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></b>: <a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D001935">D001935</a></li><li><b><a href="/wiki/Diseases_Database" title="Diseases Database">DiseasesDB</a></b>: <a rel="nofollow" class="external text" href="http://www.diseasesdatabase.com/ddb1588.htm">1588</a></li></ul></div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">External resources</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></b>: <a rel="nofollow" class="external text" href="https://www.nlm.nih.gov/medlineplus/ency/article/001396.htm">001396</a></li><li><b><a href="/wiki/EMedicine" title="EMedicine">eMedicine</a></b>: <a rel="nofollow" class="external text" href="https://emedicine.medscape.com/derm/61-overview">derm/61</a> <a rel="nofollow" class="external text" href="https://www.emedicine.com/radio/topic107.htm#">radio/107</a></li></ul></div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Congenital_malformations_and_deformations_of_face_and_neck" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Congenital_malformations_and_deformations_of_face_and_neck" title="Template:Congenital malformations and deformations of face and neck"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Congenital_malformations_and_deformations_of_face_and_neck" title="Template talk:Congenital malformations and deformations of face and neck"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Congenital_malformations_and_deformations_of_face_and_neck" title="Special:EditPage/Template:Congenital malformations and deformations of face and neck"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Congenital_malformations_and_deformations_of_face_and_neck" style="font-size:114%;margin:0 4em"><a href="/wiki/Congenital_disorder" class="mw-redirect" title="Congenital disorder">Congenital</a> malformations and deformations of <a href="/wiki/Face" title="Face">face</a> and <a href="/wiki/Neck" title="Neck">neck</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Face" title="Face">Face</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Jaw" title="Jaw">jaw</a>:</i> <a href="/wiki/Otocephaly" title="Otocephaly">Otocephaly</a></li></ul> <ul><li><i><a href="/wiki/Human_mouth" title="Human mouth">mouth</a>:</i> <a href="/wiki/Macrostomia" title="Macrostomia">Macrostomia</a></li> <li><a href="/wiki/Microstomia" title="Microstomia">Microstomia</a></li></ul> <ul><li><i><a href="/wiki/Lip" title="Lip">lip</a>:</i> <a href="/wiki/Macrocheilia" title="Macrocheilia">Macrocheilia</a></li> <li><a href="/wiki/Microcheilia" title="Microcheilia">Microcheilia</a></li></ul> <ul><li><i><a href="/wiki/Chin" title="Chin">chin</a>:</i> <a href="/wiki/Microgenia" title="Microgenia">Microgenia</a></li></ul> <ul><li><i>multiple/other:</i> <a href="/wiki/Hallermann%E2%80%93Streiff_syndrome" title="Hallermann–Streiff syndrome">Hallermann–Streiff syndrome</a></li> <li><a class="mw-selflink selflink">Branchial cleft cyst</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Neck" title="Neck">Neck</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Webbed_neck" title="Webbed neck">Webbed neck</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Ungrouped</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Preauricular_sinus_and_cyst" title="Preauricular sinus and cyst">Preauricular sinus and cyst</a></li></ul> </div></td></tr></tbody></table></div> <!-- NewPP limit report Parsed by mw‐web.codfw.main‐f69cdc8f6‐j7v4x Cached time: 20241122142433 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 0.465 seconds Real time usage: 0.631 seconds Preprocessor visited node count: 1544/1000000 Post‐expand include size: 41931/2097152 bytes Template argument size: 1434/2097152 bytes Highest expansion depth: 13/100 Expensive parser function count: 1/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 59286/5000000 bytes Lua time usage: 0.296/10.000 seconds Lua memory usage: 5985282/52428800 bytes Number of Wikibase entities loaded: 1/400 --> <!-- Transclusion expansion time report 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