Idiotype Specific Antibody Discovery Services

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Anti-ID Abs play a vital role in the development of drugs. On the one hand, anti-ID Abs can serve as a valuable reference for immunogenicity analysis. On the other hand, they are also vital tools for pharmacokinetic/pharmacodynamics (PK/PD) studies. Creative Biolabs offers unparalleled anti-ID Abs production and downstream testing services. We are committed to developing anti-ID Abs with high specificity, high affinity and high sensitivity from different species, such as rabbit, chicken, cow, sheep, mice, rats and humans to meet your unique needs. </p> <p class="ServiceShowPic"> <img src="static/img/1-5-anti-idiotype-antibody-production-services-1.jpg" width="600" height="180" loading="lazy" alt="1-5-anti-idiotype-antibody-production-services-1.jpg" /> Fig.4 The structure of antibody. (Creative Biolabs Original) </p> <h2 id="tab2" class="h2_tit page_tab_margin"> Types of Anti-ID Abs </h2> <div class="table-responsive"> <table border="1" cellspacing="0" cellpadding="0" class=" tablecontentshow" width="100%"> <tbody> <tr> <td width="33%" style="text-align:center;"> <img src="static/img/1-5-anti-idiotype-antibody-production-services-2.jpg" width="200" height="177" loading="lazy" alt="1-5-anti-idiotype-antibody-production-services-2.jpg" /> </td> <td width="33%" style="text-align:center;"> <img src="static/img/1-5-anti-idiotype-antibody-production-services-3.jpg" width="250" height="177" loading="lazy" alt="1-5-anti-idiotype-antibody-production-services-3.jpg" /> </td> <td width="33%" style="text-align:center;"> <img src="static/img/1-5-anti-idiotype-antibody-production-services-4.jpg" width="250" height="177" loading="lazy" alt="1-5-anti-idiotype-antibody-production-services-4.jpg" /> </td> </tr> <tr> <td bgcolor="#9CB5F5"> <strong>Antigen Blocking Type</strong> </td> <td bgcolor="#9CB5F5"> <strong>Antigen Non-blocking Type</strong> </td> <td bgcolor="#9CB5F5"> <strong>Drug-target Complex Specific Abs</strong> </td> </tr> <tr> <td> <strong>Antigen binding</strong>: Inhibitory / neutralizing </td> <td> <strong>Antigen binding</strong>: Non-inhibitory </td> <td> <strong>Antigen binding</strong>: Non-inhibitory </td> </tr> <tr> <td> <strong>Applications</strong>: Detection of free Ab drug and partially bound antibody drugs </td> <td> <strong>Applications</strong>: Detection of total Ab drug </td> <td> <strong>Applications</strong>: Detection of bound Ab drug only </td> </tr> </tbody> </table> </div> <h2 id="tab3" class="h2_tit page_tab_margin"> Anti-ID Ab Development Summary </h2> <div class="table-responsive"> <table border="1" cellspacing="0" cellpadding="0" class=" tablecontentshow" width="100%"> <tbody> <tr> <td bgcolor="#9CB5F5" width="45%"> <strong>Services</strong> </td> <td bgcolor="#9CB5F5" width="40%"> <strong>Delivery</strong> </td> <td bgcolor="#9CB5F5" width="15%"> <strong>Lead time</strong> </td> </tr> <tr> <td> <strong>Anti-ID Rabbit Polyclonal Ab Preparation Service</strong> </td> <td> Purified Ab;<br /> Ab QC Report </td> <td> 3.5 months </td> </tr> <tr> <td> <strong>Anti-ID Mouse Monoclonal Ab Preparation Service</strong> </td> <td> Compete and/or non-compete purified Abs; Ab QC Report; Hybridoma cell line </td> <td> 5 months </td> </tr> <tr> <td> <strong>Phage Displayed Library Screening of Anti-ID Ab</strong> </td> <td> Purified Ab; Plasmid; Strain; Ab sequences, Ab QC Report </td> <td> 4 months </td> </tr> <tr> <td> <strong>Development of Immunogenicity Detection Kits</strong> </td> <td> Kit; Manual; R&D report </td> <td> 3.5 months </td> </tr> <tr> <td> <strong>Development of PK Detection Kits</strong> </td> <td> Kit; Manual; R&D report </td> <td> 3.5 months </td> </tr> </tbody> </table> </div> <h2> Featured Anti-ID Ab Services </h2> <div class="table-responsive"> <table border="0" cellspacing="0" cellpadding="0" class=" tablecontentshow ke-zeroborder" width="100%"> <tbody> <tr> <td width="50%"> <a href="/Anti-Idiotypic-Antibodies-Production-service-detecting-FREE-antibodies.html">FREE Antibodies</a> </td> <td width="50%"> <a href="/Murine-Anti-Idiotypic-Antibodies-Production-service.html">Murine Anti-idiotypic Antibody</a> </td> </tr> <tr> <td> <a href="/Anti-Idiotypic-Antibodies-Prodution-detecting-TOTAL-antibodiese.html">TOTAL Antibodies</a> </td> <td> <a href="/Rabbit-Anti-Idiotypic-Antibodies-Production-service.html">Rabbit Anti-idiotypic Antibody</a> </td> </tr> <tr> <td> <a href="/Anti-Idiotypic-Antibodies-Production-service-detecting-BOUND-antibodies.html">BOUND Antibodies</a> </td> <td> <a href="/Chicken-Anti-Idiotypic-Antibodies-Production-service.html">Chicken Anti-idiotypic Antibody</a> </td> </tr> <tr> <td> <a href="/Anti-Idiotypic-Antibodies-Production-service-detecting-T-cell-receptors.html">T Cell Receptors</a> </td> <td> <a href="/generation-of-bsab-specific-anti-idiotypic-antibody.html">Anti-idiotypic Antibody Production of BsAb</a> </td> </tr> <tr> <td> <a href="camel-anti-idiotypic-antibodies-sdabs-production-service.html">Single Domain Anti-idiotypic Antibody</a> </td> <td> <a href="/anti-idiotypic-antibody-production-for-ada-assay.html">Anti-idiotypic Antibody Production for ADA Assay</a> </td> </tr> <tr> <td> <a href="/anti-idiotypic-antibody-production-for-pk-assay.html">Anti-idiotypic Antibody Production for PK Assay</a> </td> <td> </td> </tr> </tbody> </table> </div> <h2> Featured Technology Platforms </h2> <div class="table-responsive"> <table border="1" cellspacing="0" cellpadding="0" class=" tablecontentshow" width="100%"> <tbody> <tr> <td bgcolor="#9CB5F5" width="33%"> <strong>Hybridoma Platform</strong> </td> <td bgcolor="#9CB5F5" width="33%"> <strong>Phage Display & Antibody Library</strong> </td> <td bgcolor="#9CB5F5" width="33%"> <strong>Polyclonal Antibody Development</strong> </td> </tr> <tr> <td style="text-align:center;"> <img src="static/img/1-5-anti-idiotype-an7ibody-production-services-14.jpg" width="300" height="187" loading="lazy" alt="1-5-anti-idiotype-antibody-production-services-14.jpg" /> <br /> Fig.8 Hybridoma platform. (Saeed, et al., 2017) </td> <td style="text-align:center;"> <img src="static/img/1-5-anti-idiotype-an7ibody-production-services-15.jpg" width="300" height="157" loading="lazy" alt="1-5-anti-idiotype-antibody-production-services-15.jpg" /> <br /> Fig.9 Phage display & antibody library. (Wu, et al., 2016) </td> <td style="text-align:center;"> <img src="static/img/1-5-anti-idiotype-an7ibody-production-services-16.jpg" width="200" height="187" loading="lazy" alt="1-5-anti-idiotype-antibody-production-services-16.jpg" /> <br /> Fig.10 Polyclonal antibody development. (Garcia-Calvo, et al.,2020) </td> </tr> </tbody> </table> </div> <h2 id="tab4" class="h2_tit page_tab_margin"> Services Highlight </h2> <ul class="ullist"> <li> <strong>High-quality Abs</strong><br /> High specificity and sensitivity Abs against your targets of interest. </li> <li> <strong>Fast turnaround time</strong><br /> The fastest production cycle is about 3.5 months. </li> <li> <strong>Applicable to multiple drugs</strong><br /> Applicable drugs include but are not limited to: monoclonal antibody, polypeptide, protein, compound, cell line, DNA and so on. </li> <li> <strong>One-stop service</strong><br /> Provide one-stop technical services, from antibody development to preclinical research of therapeutic Abs. </li> <li> <strong>Customizable service</strong><br /> Provide customized experimental solutions according to your specific needs, saving you time and cost. </li> </ul> <h2 id="tab5" class="h2_tit page_tab_margin"> <a href="/resource/pdf/com/case-study/A20-Case-Study-Anti-ID-antibody-development.pdf">Case Study - Anti-ID antibody development <img src="static/images/iconpng.png" width="25" height="25" loading="lazy" /> </a> </h2> <p style="text-align:center;"> Case A </p> <p class="ServiceShowPic"> <img src="static/img/1-5-anti-idiotype-antibody-production-services-5.jpg" width="386" height="313" loading="lazy" alt="Ab Structure Analysis. (Creative Biolabs Original)" />Fig. 1 Anti-ID monoclonal Ab has no cross reaction with isotype human IgG and total human IgG. </p> <p style="text-align:center;"> Case B </p> <p class="ServiceShowPic"> <img src="static/img/1-5-anti-idiotype-antibody-production-services-6.jpg" width="588" height="156" loading="lazy" alt="Antigen blocking type. (Creative Biolabs Original)" />Fig. 2 Competition ELISA of Anti-ID monoclonal Ab. </p> <p style="text-align:center;"> Case C </p> <p class="ServiceShowPic"> <img src="static/img/1-5-anti-idiotype-an7ibody-production-services-7.jpg" width="588" height="166" loading="lazy" alt="Fig.3 Antigen non-blocking type. (Creative Biolabs Original)" />Fig. 3 Anti-ID polyclonal Ab-good specificity, little cross-reactivity with human IgG. </p> <h2 id="tab6" class="h2_tit page_tab_margin"> Applications </h2> <div class="table-responsive"> <table border="0" cellspacing="0" cellpadding="0" class=" tablecontentshow ke-zeroborder" width="100%"> <tbody> <tr> <td width="33%" style="text-align:center;" valign="top"> <img src="static/img/1-5-anti-idiotype-an7ibody-production-services-8.jpg" width="262" height="175" loading="lazy" alt="Ab drug-target complex specific. (Creative Biolabs Original)" style="margin-bottom:15px;" /><br /> PK and PD Analysis of Ab Drugs </td> <td width="33%" style="text-align:center;" valign="top"> <img src="static/img/1-5-anti-idiotype-an7ibody-production-services-9.jpg" width="262" height="175" loading="lazy" alt="Anti-ID monoclonal Ab has no cross reaction with isotype human IgG and total human IgG. (Creative Biolabs Original)" style="margin-bottom:15px;" /><br /> Immunogenicity study of Ab drugs </td> <td width="33%" style="text-align:center;" valign="top"> <img src="static/img/1-5-anti-idiotype-an7ibody-production-services-10.jpg" width="262" height="175" loading="lazy" alt="Competition ELISA of Anti-ID monoclonal Ab. (Creative Biolabs Original)" style="margin-bottom:15px;" /><br /> Preclinical research of therapeutic Abs </td> </tr> <tr> <td style="text-align:center;" valign="top"> <img src="static/img/1-5-anti-idiotype-an7ibody-production-services-11.jpg" width="262" height="175" loading="lazy" alt="Anti-ID polyclonal Ab -good specificity, little cross-reactivity with human IgG. (Creative Biolabs Original)" style="margin-bottom:15px;" /><br /> Controls in Ab blocking assays </td> <td style="text-align:center;" valign="top"> <img src="static/img/1-5-anti-idiotype-an7ibody-production-services-12.jpg" width="262" height="175" loading="lazy" alt="PK and PD Analysis of Ab Drugs. (Creative Biolabs Authorized)" style="margin-bottom:15px;" /><br /> Controls in ligand binding neutralizing assays </td> <td style="text-align:center;" valign="top"> <img src="static/img/1-5-anti-idiotype-an7ibody-production-services-13.jpg" width="262" height="175" loading="lazy" alt="Immunogenicity study of Ab drugs. (Creative Biolabs Authorized)" style="margin-bottom:15px;" /><br /> Suitable for high-throughput detection of specific Ab drug content in the blood </td> </tr> </tbody> </table> </div> <p> If you are interested in our anti- ID Ab production services, please <a href="/contactus.html">contact us</a> in time to get a detailed quotation. </p> <p class="Reference"> <strong>References</strong> </p> <ol class="ollist decimal Reference"> <li> Saeed, Abdullah FUH, et al. "Antibody engineering for pursuing a healthier future."<em> Frontiers in microbiology</em> (2017): 495.<strong> </strong> </li> <li> Wu, Chien-Hsun, et al. "Advancement and applications of peptide phage display technology in biomedical science." <em>Journal of biomedical science</em> 23.1 (2016): 1-14. </li> <li> Garcia-Calvo, Eduardo, et al. "From polyclonal sera to recombinant antibodies: A review of immunological detection of gluten in foodstuff." <em>Foods</em> 10.1 (2020): 66. </li> </ol><br> <p class="pronote"><i class="fa fa-exclamation-triangle"></i>All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.</p> <div class="related-sections"> <b>Related Sections</b> <b>Services</b> <ul class="related-sections-ul"> <li><a href="/phage-display-library-construction.html" >Phage Display Library Construction Services</a></li> <li><a href="/phage-display-library-screening.html" >Phage Display Library Screening Services</a></li> <li><a href="/Native-TM-Antibody-Discovery-Service.html" >Single B Cell Sorting based Native™ Antibody Discovery Services</a></li> <li><a href="/monoclonal-antibody-production-rat-mouse.html" >Mouse Hybridoma based Antibody Discovery Service</a></li> <li><a href="/antibody-characterization.html" >What is Antibody Characterization?</a></li> <li><a href="/antibody-affinity-maturation.html" >Affinity Maturation Services</a></li> <li><a href="/Antibody-Stability-Improvement.html" >Stability Improvement Service</a></li> <li><a href="/Screening-for-Internalizing-Antibodies-and-Peptides.html" >Internalizing Antibody 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