Premade Library based Binder Discovery Services

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We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects. </p> <b class="Highlights_tit">Highlights</b> <ul class="HighlightsArea"> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Abouts-menu-lights-pic-1.jpg" srcset="static/images/Abouts-menu-lights-pic-1.webp 1x" width="200" height="131" loading="lazy"><a href="aboutus.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>About CBL </a> </li> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Abouts-menu-lights-pic-2.jpg" srcset="static/images/Abouts-menu-lights-pic-2.webp 1x" width="200" height="131" loading="lazy"><a href="contactus.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>Contact Us </a> </li> </ul> </li> </ul> </div> </div> </li> </ul> <script> window.addEventListener('load',function(){ var arr = ['/drug-discovery/therapeutics/','/bioconjugation/','/adc/']; $('.mennav ul li a').each(function(){ var $this = $(this); var href = $this.attr("href").toLocaleLowerCase(); $.each(arr, function(index, value) { if (href && href.startsWith(value)) { $this.attr('target', '_blank'); } }); }); }); </script> </div> <div class="top-search search-group"> <div class="col-md-5 col-sm-6"> <label class="radio-inline"><input type="radio" name="search" class="rdo_productsearch" value="product" data-type="product" placeholder="Please input cat#, product name, abbr, or keywords."> Product</label> <label class="radio-inline"><input type="radio" name="search" class="rdo_servicesearch" value="service" data-type="service" placeholder="Please input your keywords."> Service</label> <label class="radio-inline"><input type="radio" name="search" class="rdo_googlesearch" value="google" data-type="google" placeholder="Please input your keywords." checked="checked"> Keyword</label> </div> <div class="col-md-7 col-sm-6 search-div"> <input id="keys" name="keys" placeholder="Please input your keywords." class="search-input"> <div class="selectItems"></div> <span class="search_btn"><i class="fa fa-search"></i></span> </div> </div> </div> <div class="searchShow"> <div class="searchtopbg"></div> <span class="searchclosed"><i class="fa fa-times"></i>Close</span> <div class="addsearch search-group"></div> </div> <div class="banner_inpage services_bg_2"> <div class="auto-container small_content-width about_container"> <ul class="bread-crumb clearfix"> <li><a href="/">Home</a></li> <li><a href="javascrpt:void(0)">Discovery</a></li><li><a href="javascrpt:void(0)">By Technology</a></li> <li>Premade Library based Binder Discovery</li> </ul> <p>"Creative Biolabs is committed to providing highly customized comprehensive solutions with the best quality to advance our global clients’ projects."</p> </div> </div> <script> window.addEventListener('load', function () { if (($('.bread-crumb li:last-child').text()) == "Peer-Reviewed Publications") { $(".banner_inpage").addClass("peer-reviewed-publications_bg").removeClass("services_bg_2"); } if ($(window).hasClass('bread-crumb')) { if ($(".bread-crumb").html().indexOf("RESOURCE") > -1) { $(".pronote").hide(); } if ($(".bread-crumb").html().indexOf("Careers") > -1) { $(".pronote").hide(); } } }); </script> <div class="small_content-width services-container"> <div class="col-md-9"> <div class="inpage_section_title"> <h1>Premade Library based Binder Discovery Services</h1> </div> <div class="page-tab"> <span onclick="window.location.href=window.location.pathname+'#tab1'">Premade Libraries</span> <span onclick="window.location.href=window.location.pathname+'#tab2'">Screening Services</span> <span onclick="window.location.href=window.location.pathname+'#tab3'">Approaches</span> <span onclick="window.location.href=window.location.pathname+'#tab4'">Advantages</span> <span onclick="window.location.href=window.location.pathname+'#tab5'">Cases</span> </div> <script> window.addEventListener('load',function(){ page_tab_margin() page_tab_css(); })</script> <p> <strong>Creative Biolabs</strong> has constructed a variety of peptide and antibody libraries. These premade libraries accelerate the process of developing peptide and antibody detection reagents and drugs for our customers. </p> <h2 class="h2_tit page_tab_margin" id="tab1"> Premade Libraries </h2> <p> With years of experience in molecular biology operations and primer design, Creative Biolabs has built various high-quality libraries of multiple species and fragment types. We can use these libraries to provide screening services to our customers or license some of these libraries as products. </p> <p class="show-center"> <img src="static/img/1-1-3-premade-library-based-binder-discovery-1.jpg" width="600" height="216" loading="lazy" alt="Fig. 1 A figure to show different formats of antibody fragments. (Creative Biolabs Original)" /> </p> <h3 class="h3_tit"> Antibody Libraries </h3> <div class="provide-box-con"> <div class="tab_nav"> <span class="tab_choosebg">Human</span><span>Mouse</span><span>Rabbit</span><span>Chicken</span> <span>V<sub>H</sub>H (Camel, Llama, Alpaca)</span> <span>Humanized V<sub>H</sub>H</span> </div> <div class="tab_cont" style="display:block;">  <div class="table-responsive"> <table class="table-bordered service-table"> <tbody> <tr> <td> <strong>Antibody</strong> <strong>Library ID</strong> </td> <td> <strong>Display Technology</strong> </td> <td> <strong>Library Format</strong> </td> <td> <strong>Library Size</strong> </td> </tr> <tr> <td> <strong>HuScL-6</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve scFv </td> <td> 2.1×10<sup>11</sup> </td> </tr> <tr> <td> <strong>HuScL-7</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve scFv </td> <td> 1.1×10<sup>10</sup> </td> </tr> <tr> <td> <strong>HuScL-3S</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Semi-synthetic scFv </td> <td> >1.0×10<sup>11</sup> </td> </tr> <tr> <td> <strong>HuFabL-4</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve Fab </td> <td> 1.9×10<sup>10</sup> </td> </tr> <tr> <td> <strong>HuFabL-5</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve Fab </td> <td> 1.1×10<sup>10</sup> </td> </tr> <tr> <td> <strong>HuFabssL-1</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve & synthetic Fab </td> <td> 1.8×10<sup>10</sup> </td> </tr> <tr> <td> <strong>HuscL-YDP-3</strong> </td> <td> Yeast Display </td> <td> Naïve scFv </td> <td> 1.9×108 </td> </tr> </tbody> </table> </div>  </div> <div class="tab_cont">  <div class="table-responsive"> <table class="table-bordered service-table"> <tbody> <tr> <td> <strong>Antibody</strong> <strong>Library ID</strong> </td> <td> <strong>Display Technology</strong> </td> <td> <strong>Library Format</strong> </td> <td> <strong>Library Size</strong> </td> </tr> <tr> <td> <strong>MuScL-2</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve scFv </td> <td> 5.3×10<sup>10</sup> </td> </tr> <tr> <td> <strong>MuFabL-2</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve Fab </td> <td> 1.2×10<sup>10</sup> </td> </tr> </tbody> </table> </div>  </div> <div class="tab_cont">  <div class="table-responsive"> <table class="table-bordered service-table"> <tbody> <tr> <td> <strong>Antibody</strong> <strong>Library ID</strong> </td> <td> <strong>Display Technology</strong> </td> <td> <strong>Library Format</strong> </td> <td> <strong>Library Size</strong> </td> </tr> <tr> <td> <strong>RaFabL-1</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve Fab </td> <td> 7.5×10<sup>9</sup> </td> </tr> <tr> <td> <strong>RaFabL-2</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve Fab </td> <td> 1.2×10<sup>10</sup> </td> </tr> </tbody> </table> </div>  </div> <div class="tab_cont">  <div class="table-responsive"> <table class="table-bordered service-table"> <tbody> <tr> <td> <strong>Antibody</strong> <strong>Library ID</strong> </td> <td> <strong>Display Technology</strong> </td> <td> <strong>Library Format</strong> </td> <td> <strong>Library Size</strong> </td> </tr> <tr> <td> <strong>Chicken-ScL-2</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve scFv </td> <td> 1.1×10<sup>10</sup> </td> </tr> </tbody> </table> </div>  </div> <div class="tab_cont">  <div class="table-responsive"> <table class="table-bordered service-table"> <tbody> <tr> <td> <strong>Antibody</strong> <strong>Library ID</strong> </td> <td> <strong>Display Technology</strong> </td> <td> <strong>Library Format</strong> </td> <td> <strong>Library Size</strong> </td> </tr> <tr> <td> <strong>CaV<sub>H</sub>HL-4</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve V<sub>H</sub>H </td> <td> 2.63×10<sup>10</sup> </td> </tr> <tr> <td> <strong>CaV<sub>H</sub>HL-5</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve V<sub>H</sub>H </td> <td> 3.0×10<sup>10</sup> </td> </tr> <tr> <td> <strong>CaV<sub>H</sub>HL-6</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve V<sub>H</sub>H </td> <td> 2.43×10<sup>9</sup> </td> </tr> <tr> <td> <strong>LlaV<sub>H</sub>HL-1</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve V<sub>H</sub>H </td> <td> 2.0×10<sup>9</sup> </td> </tr> <tr> <td> <strong>LlaV<sub>H</sub>HL-2</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve V<sub>H</sub>H </td> <td> &emsp;1.8×10<sup>10</sup> </td> </tr> <tr> <td> <strong>AlV<sub>H</sub>HL-1</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve V<sub>H</sub>H </td> <td> 1.35×10<sup>10</sup> </td> </tr> <tr> <td> <strong>AlV<sub>H</sub>HL-2</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Naïve V<sub>H</sub>H </td> <td> 1.5×10<sup>11</sup> </td> </tr> <tr> <td> <strong>LlaV<sub>H</sub>HL-S1</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Synthetic V<sub>H</sub>H </td> <td> 1.5×10<sup>11</sup> </td> </tr> <tr> <td> <strong>CaV<sub>H</sub>HL-S2</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Synthetic V<sub>H</sub>H </td> <td> 5.4×10<sup>10</sup> </td> </tr> <tr> <td> <strong>CaV<sub>H</sub>HL-S3</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Synthetic V<sub>H</sub>H </td> <td> 2.2×10<sup>10</sup> </td> </tr> <tr> <td> <strong>CaV<sub>H</sub>HL-S4</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Semi-synthetic V<sub>H</sub>H </td> <td> 5.3×10<sup>10</sup> </td> </tr> </tbody> </table> </div>  </div> <div class="tab_cont">  <div class="table-responsive"> <table class="table-bordered service-table"> <tbody> <tr> <td> <strong>Antibody</strong> <strong>Library ID</strong> </td> <td> <strong>Display Technology</strong> </td> <td> <strong>Library Format</strong> </td> <td> <strong>Library Size</strong> </td> </tr> <tr> <td> <strong>HuV<sub>H</sub>HL-S1</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Synthetic V<sub>H</sub>H </td> <td> >1.0×10<sup>11</sup> </td> </tr> <tr> <td> <strong>HuV<sub>H</sub>HL-S2</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Semi-synthetic V<sub>H</sub>H </td> <td> >1.0×10<sup>10</sup> </td> </tr> </tbody> </table> </div>  </div> <h3 class="h3_tit"> Peptide Libraries </h3> <div class="tab-box-con"> <div class="tab_nav"> <span class="tab_choosebg">Linear</span><span>Cyclic</span><span>Others</span> </div> <div class="tab_cont" style="display:block;">  <div class="table-responsive"> <table class="table-bordered service-table"> <tbody> <tr> <td> <strong>Peptide Library ID</strong> </td> <td> <strong>Phage Display</strong> </td> <td> <strong>Library Format</strong> </td> <td> <strong>Library Size</strong> </td> </tr> <tr> <td> <strong>TriCo-16</strong> </td> <td> pIII-fusion, True Phage Display </td> <td> 16-mer peptide library </td> <td> 1.1×10<sup>10</sup> </td> </tr> <tr> <td> <strong>TriCo-20</strong> </td> <td> pIII-fusion, True Phage Display </td> <td> 20-mer peptide library </td> <td> 1.3×10<sup>10</sup> </td> </tr> </tbody> </table> </div>  </div> <div class="tab_cont">  <div class="table-responsive"> <table class="table-bordered service-table"> <tbody> <tr> <td> <strong>Peptide Library ID</strong> </td> <td> <strong>Phage Display</strong> </td> <td> <strong>Library Format</strong> </td> <td> <strong>Library Size</strong> </td> </tr> <tr> <td> <strong>TriCo-C9</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Cyclic 9-mer peptide library </td> <td> 1.10×10<sup>10</sup> </td> </tr> <tr> <td> <strong>TriCo-C9L</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> Cyclic 9-mer peptide library </td> <td> 6.8×10<sup>10</sup> </td> </tr> </tbody> </table> </div>  </div> <div class="tab_cont">  <div class="table-responsive"> <table class="table-bordered service-table"> <tbody> <tr> <td> <strong>Peptide Library ID</strong> </td> <td> <strong>Phage Display</strong> </td> <td> <strong>Library Format</strong> </td> <td> <strong>Library Size</strong> </td> </tr> <tr> <td> <strong>Protease-10A</strong> </td> <td> pIII-fusion, Phagemid Phage Display </td> <td> HiAffi tagged 10 mer peptide library </td> <td> 1.10×10<sup>10</sup> </td> </tr> </tbody> </table> </div>  </div> </div> <script> window.addEventListener('load',function(){ // $(function () { Tab_("provide-box-con") Tab_("tab-box-con"); // }) }); </script> <h2 class="h2_tit page_tab_margin" id="tab2"> Premade Library based Screening Services </h2> <p> The high-quality premade libraries constructed by Creative Biolabs facilitate the discovery of peptide and antibody drugs. We can provide premade library screening services for different target types, such as peptides, proteins, and cells. In addition, thanks to many years of screening experience and multiple screening strategies, we can offer peptide and antibody drug development services targeting precise epitopes, such as receptor and ligand binding epitopes, TCR-like epitopes, and idiotypic epitopes. These screened binders are suitable for a variety of immunotherapies, such as CAR-T, bifunctional antibodies, ADC, and immune checkpoints. </p> <h3 class="h3_tit"> <a href="/premade-phage-display-antibody-library-screening-service.html">Premade Antibody Library Screening Services</a> </h3> <div class=" tabpro_show" style="display:block;"> <ul> <li> <a href="/functional-human-antibody-discovery-from-premade-phage-displayed-human-antibody-library.html">Functional Human Antibody Discovery</a> </li> <li> Various types of premade human antibody libraries<br /> Diverse genetic materials, high diversity libraries<br /> Large library capacity, >2.1x10<sup>11</sup><br /> High affinity, from 10-7 to 10-9 M </li> </ul> <ul> <li> <a href="/anti-peptide-protein-antibody-discovery-from-premade-phage-displayed-antibody-library.html">Anti-Peptide/Protein Antibody Discovery</a> </li> <li> For purified proteins, protein segments, synthetic peptide, Toxic proteins, poorly immunogenic proteins </li> </ul> <ul> <li> <a href="/anti-cell-based-target-antibody-discovery-from-premade-phage-displayed-antibody-library.html">Anti-Cell-Based Target Antibody Discovery</a> </li> <li> For anti-membrane protein antibody discovery, such as GPCRs, transporter Proteins, and ion channel proteins.<br /> For Cell internalization antibody screening </li> </ul> <ul> <li> <a href="/bifunctional-antibodies-discovery-from-premade-phage-displayed-antibody-library.html">Bifunctional Antibodies Discovery</a> </li> <li> Various types of premade libraries suitable for a variety of targets </li> </ul> <ul> <li> <a href="/anti-epitope-antibody-discovery-from-premade-phage-displayed-antibody-library.html">Anti-Epitope Antibody Discovery</a> </li> <li> <a href="/tcr-like-antibody-discovery-from-premade-phage-displayed-antibody-library.html">TCR-like antibody</a><br /> <a href="/anti-idiotype-antibody-discovery-from-premade-phage-displayed-antibody-library.html">Anti-idiotype antibody discovery</a><br /> <a href="/anti-ptm-antibody-discovery-from-premade-phage-displayed-antibody-library.html">Anti-PTM antibody</a><br /> Receptor and ligand binding epitope antibodies </li> </ul> <ul> <li> <a href="/anti-disease-specific-target-antibody-discovery-from-premade-phage-displayed-antibody-library.html">Anti-Disease-specific Target Antibody Discovery</a> </li> <li> <a href="/anti-tumor-specific-target-antibody-discovery-from-premade-phage-displayed-antibody-library.html">Tumors</a>, <a href="/anti-infectious-diseases-specific-antibody-discovery-from-premade-phage-displayed-antibody-library.html">infectious diseases</a>, <a href="/anti-inflammation-diseases-specific-antibody-discovery-from-premade-phage-displayed-antibody-library.html">inflammation diseases</a>, <a href="/anti-autoimmune-disorders-specific-antibody-discovery-from-premade-phage-displayed-antibody-library.html">autoimmune disorders</a>, and <a href="/anti-allograft-rejection-specific-antibody-discovery-from-premade-phage-displayed-antibody-library.html">allograft rejection</a>. </li> </ul> <ul> <li> <a href="/antibody-discovery-for-immunotherapy-from-premade-phage-displayed-antibody-library.html">Antibody Discovery for Immunotherapy</a> </li> <li class="ap-abbreviations"> <a href="/antibody-discovery-for-car-t-therapy-from-premade-phage-displayed-antibody-library.html">CAR-T therapy</a><br /> <a href="/antibody-discovery-for-immune-checkpoint-from-premade-phage-displayed-antibody-library.html">Immune checkpoint</a><br /> <a href="/antibody-discovery-for-adc-therapy-from-premade-phage-displayed-antibody-library.html">ADC therapy</a> </li> </ul> </div> <h3 class="h3_tit"> <a href="/premade-phage-display-peptide-library-screening-service.html">Premade Peptide Library Screening Service</a> </h3> <ul class=" ullist"> <li> <a href="/particulate-matter-binding-peptides-identification-service.html">Particulate Matter Binding Peptide Screening Service</a> </li> <li> <a href="/soft-matter-binding-peptides-identification-services.html">Soft Matter Binding Peptide Screening Services</a> </li> <li> <a href="/cell-selective-peptides-discovery-service.html">Cell-Selective Peptide Discovery Service</a> </li> <li> <a href="/disease-specific-peptides-discovery-service.html">Disease-Specific Peptide Discovery Service</a> </li> </ul> <h2 class="h2_tit page_tab_margin" id="tab3"> Screening Approaches </h2> <p> With decades of experience, scientists at Creative Biolabs specialize in library screening projects. We have established a variety of screening strategies to achieve customized goals best: </p> <ul class=" ullist"> <li> <a href="/solid-phase-library-screening.html">Solid-Phase Screening</a> </li> <li> <a href="/solution-sorting-library-screening.html">Solution-Sorting Screening</a> </li> <li> <a href="/cell-based-library-screening.html">Cell-based Screening</a> </li> <li> <a href="/In-vivo-Phage-Display-Service.htm"><em>In Vivo</em> Screening</a> </li> <li> <a href="/Ex-vivo-Phage-Display-Services.htm"><em>Ex Vivo</em> Screening</a> </li> </ul> <h2 class="h2_tit page_tab_margin" id="tab4"> Advantages of Premade Library </h2> <p> Compared to other approaches, premade libraries offer several advantages: </p> <p> <strong>Time Efficiency</strong> - Creative Biolabs provides customers with a rich selection of ready-to-use premade libraries. It saves time on sample collection and library construction. This speeds up the development process of ideal binders and allows you to focus more on the unique aspects of your application. </p> <p> <strong>High Quality & Reliability</strong> – Creative Biolabs can construct large-capacity and high-diversity libraries and conduct strict quality control and batch management on the libraries, thereby improving the screening success rate. </p> <p> <strong>Cost-Effectiveness</strong> - Using premade libraries can reduce the cost of building libraries, thereby reducing development costs. </p> <p> <strong>Species Suitability</strong> - Human-derived premade antibody library avoids the subsequent humanization process. And the antibodies obtained from the naïve antibody library have good developability. </p> <h2 class="h2_tit page_tab_margin" id="tab5"> Cases </h2> <h3 class="h3_tit page_tab_margin"> Case 1- Internalization Antibody Discovery from a Premade Phage Display Human Antibody Library </h3> <p class="show-center"> <img src="static/img/1-1-3-premade-library-based-binder-discovery-2.jpg" width="443" height="423" loading="lazy" alt="Fig. 2 A FACS data indicates an internalization antibody discovered from a premade phage display human antibody library was observed to internalize into both human and mouse target cells specifically. (Creative Biolabs Original)" /> </p> <h3> Results </h3> <p> The selected candidate antibody from a premade human antibody library was observed to internalize into both human and mouse target cells specifically, indicating that the discovery of internalization antibody was successful. </p> <h3 class="h3_tit page_tab_margin"> Case 2 - Premade Antibody Library Screening for MHC-Peptide Complex </h3> <p class="show-center"> <img src="static/img/1-1-3-premade-library-based-binder-discovery-3.jpg" width="520" height="264" loading="lazy" alt="Fig. 3 A ELISA data shows there are 7 unique clones identified from premade libarary to recognize the target MHC-peptide positively. (Creative Biolabs Original)" /> </p> <h3> Results </h3> <p> 7 unique clones were identified to recognize the target MHC-peptide positively. </p> </div><br> <p class="pronote"><i class="fa fa-exclamation-triangle"></i>All listed services and products are For Research Use Only. 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