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Maternal hyperglycemia affects cell proliferation signalling and stromal organization in the prostate of neonatal and juvenile rat offspring. <em class='incite-journal-name' onclick='ShowInCiteJournal(828);'>Acta Histochem</em> 2024;<b>126</b>:152193. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39244868' target='_blank'>39244868</a> DOI: <a href='https://dx.doi.org/10.1016/j.acthis.2024.152193' target='_blank'>10.1016/j.acthis.2024.152193</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.acthis.2024.152193','39244868', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.acthis.2024.152193' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(828);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.acthis.2024.152193" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Gestational diabetes mellitus is a common medical complication during pregnancy. It creates a hyperglycemic environment and impacts offspring development, increasing the risk of long-term complications, including obesity, impaired glucose metabolism and cardiovascular disease. The impact of gestational diabetes on the prostates of adult offspring has already been described; however, it is not known whether these effects are due only to the maternal condition or whether the offspring develop them throughout life. This investigation evaluated the prostates of neonatal and juvenile offspring of hyperglycemic rats due to diabetes. Diabetes was induced with streptozotocin (50 mg/kg, ip) in pregnant Wistar rats and the prostates of 7- or 30-day-old pups from healthy (PC7, PC30) or diabetic (PD7, PD30) mothers were evaluated. We found reduced body weight in pups of PD7 and PD30 and prostate weight in PD30. Prostate branching was not affected, but a reduction in apoptotic levels was associated with impaired acinar bud canalization in neonates. Additionally, PD7 presented reduced ERK1/2 phosphorylation, cell proliferation and collagen, but fibroblasts were increased. In PD30, there was a reduction in the area of the secretory epithelium and stroma, but the luminal area was increased. Moreover, fibroblasts, smooth muscle cells, collagen and metalloproteinase 2 were decreased in these juvenile pups. These data indicate that maternal hyperglycemia inactivates an important cell proliferation signaling pathway in the prostate in the first postnatal days (which is restored in the juvenile period), but it was not sufficient to avoid epithelial and stromal atrophy. This effect on postnatal gland development may impact the reproductive capacity of the prostate in adult life. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Development</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gestational+diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gestational diabetes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostate</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pregnancy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pregnancy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostate%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostate/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostate%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostate/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostate%2fgrowth+%26amp%3b+development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostate/growth & development</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%2c+Newborn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals, Newborn</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes%2c+Gestational%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes, Gestational/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes%2c+Gestational%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes, Gestational/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prenatal+Exposure+Delayed+Effects%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prenatal Exposure Delayed Effects/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prenatal+Exposure+Delayed+Effects%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prenatal Exposure Delayed Effects/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Sabatini S</b>, Sen P, Carli F, Pezzica S, Rosso C, Lembo E, Verrastro O, Daly A, Govaere O, Cockell S, Hyötyläinen T, Mingrone G, Bugianesi E, Anstee QM, Orešič M, Gastaldelli A. Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis. <em class='incite-journal-name' onclick='ShowInCiteJournal(171780);'>Cell Rep Med</em> 2024;<b>5</b>:101820. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39566466' target='_blank'>39566466</a> DOI: <a href='https://dx.doi.org/10.1016/j.xcrm.2024.101820' target='_blank'>10.1016/j.xcrm.2024.101820</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.xcrm.2024.101820','39566466', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.xcrm.2024.101820' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(171780);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/25/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.xcrm.2024.101820" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are associated with a high prevalence of type 2 diabetes (T2D). Individuals with MASLD exhibit insulin resistance (IR) and hyperglycemia, but it is unclear whether hepatic glucose production (HGP) is increased with MASLD severity. We evaluated HGP in a cohort of histologically characterized individuals with MASL/MASH using stable isotope infusion (6,6-2H2-glucose, U-2H5-glycerol) and liver-specific genome-scale metabolic models (GEMs). Tracer-measured HGP is increased with liver fibrosis and inflammation, but not steatosis, and is associated with lipolysis and IR. The GEM-derived gluconeogenesis is elevated due to high glucogenic/energy metabolite uptakes (lactate, glycerol, and free fatty acid [FFA]), and the expression of insulin action genes (IRS1, IRS2, and AKT2) is reduced in MASH with fibrosis F2-F4, with/without T2D, suggesting these as putative mechanisms for increased fasting HGP and hyperglycemia. In conclusion, elevated HGP, lipolysis, and IR help to explain the mechanisms for the increased risk of hyperglycemia and T2D in MASH. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MASH%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MASH</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MASLD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MASLD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NASH%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22insulin+resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">insulin resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22liver+fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">liver fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22type+2+diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">type 2 diabetes</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a 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Substrate Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Insulin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Insulin/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Chen S</b>, Sun D, Zhang S, Xu L, Wang N, Li H, Xu X, Wei F. TIN2 modulates FOXO1 mitochondrial shuttling to enhance oxidative stress-induced apoptosis in retinal pigment epithelium under hyperglycemia. <em class='incite-journal-name' onclick='ShowInCiteJournal(4600);'>Cell Death Differ</em> 2024;<b>31</b>:1487-1505. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39080375' target='_blank'>39080375</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519896' target='_blank'>PMC11519896</a> DOI: <a href='https://dx.doi.org/10.1038/s41418-024-01349-8' target='_blank'>10.1038/s41418-024-01349-8</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41418-024-01349-8','39080375', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(3);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41418-024-01349-8' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4600);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/30/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1038/s41418-024-01349-8" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Progressive dysfunction of the retinal pigment epithelium (RPE) and the adjacent photoreceptor cells in the outer retina plays a pivotal role in the pathogenesis of diabetic retinopathy (DR). Here, we observed a marked increase in oxidative stress-induced apoptosis in parallel with higher expression of telomeric protein TIN2 in RPE cells under hyperglycemia in vivo and in vitro. Delving deeper, we confirm that high glucose-induced elevation of mitochondria-localized TIN2 compromises mitochondrial activity and weakens the intrinsic antioxidant defense, thereby leading to the activation of mitochondria-dependent apoptotic pathways. Mechanistically, mitochondrial TIN2 promotes the phosphorylation of FOXO1 and its relocation to the mitochondria. Such translocation of transcription factor FOXO1 not only promotes its binding to the D-loop region of mitochondrial DNA-resulting in the inhibition of mitochondrial respiration-but also hampers its availability to nuclear target DNA, thereby undermining the intrinsic antioxidant defense. Moreover, TIN2 knockdown effectively mitigates oxidative-induced apoptosis in diabetic mouse RPE by preserving mitochondrial homeostasis, which concurrently prevents secondary photoreceptor damage. Our study proposes the potential of TIN2 as a promising molecular target for therapeutic interventions for diabetic retinopathy, which emphasizes the potential significance of telomeric proteins in the regulation of metabolism and mitochondrial function. Created with BioRender ( https://www.biorender.com/ ). </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22experimental+models+of+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">experimental models of disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">diseases</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retinal+Pigment+Epithelium%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retinal Pigment Epithelium/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retinal+Pigment+Epithelium%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retinal Pigment Epithelium/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Forkhead+Box+Protein+O1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Forkhead Box Protein O1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Retinopathy%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Retinopathy/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Retinopathy%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Retinopathy/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China+(National+Science+Foundation+of+China)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Grant No.81970812 National Natural Science Foundation of China (National Science Foundation of China)</a></li></ul> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Cui G</b>, Moustafa DA, Zhao S, Cegla AV, Lyles JT, Goldberg JB, Chandler JD, McCarty NA. Chronic hyperglycemia aggravates lung function in a <i>Scnn1b</i>-Tg murine model. <em class='incite-journal-name' onclick='ShowInCiteJournal(169367);'>Am J Physiol Lung Cell Mol Physiol</em> 2024;<b>327</b>:L473-L486. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39010826' target='_blank'>39010826</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11482466' target='_blank'>PMC11482466</a> DOI: <a href='https://dx.doi.org/10.1152/ajplung.00279.2023' target='_blank'>10.1152/ajplung.00279.2023</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1152/ajplung.00279.2023','39010826', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(4);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1152/ajplung.00279.2023' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/05/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/17/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1152/ajplung.00279.2023" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cystic fibrosis-related diabetes (CFRD), the most common comorbidity in cystic fibrosis (CF), leads to increased mortality by accelerating the decline in lung function. Scnn1b-Tg transgenic mice overexpressing the epithelial sodium channel β subunit exhibit spontaneous CF-like lung disease, including airway mucus obstruction and chronic inflammation. Here, we established a chronic CFRD-like model using Scnn1b-Tg mice made diabetic by injection of streptozotocin (STZ). In Ussing chamber recordings of the trachea, Scnn1b-Tg mice exhibited larger amiloride-sensitive currents and forskolin-activated currents, without a difference in adenosine triphosphate (ATP)-activated currents compared with wild-type (WT) littermates. Both diabetic WT (WT-D) and diabetic Scnn1b-Tg (Scnn1b-Tg-D) mice on the same genetic background exhibited substantially elevated blood glucose at 8 wk; glucose levels also were elevated in bronchoalveolar lavage fluid (BALF). Bulk lung RNA-seq data showed significant differences between WT-D and Scnn1b-Tg-D mice. Neutrophil counts in BALF were substantially increased in Scnn1b-Tg-D lungs compared with controls (Scnn1b-Tg-con) and compared with WT-D lungs. Lung histology data showed enhanced parenchymal destruction, alveolar wall thickening, and neutrophilic infiltration in Scnn1b-Tg-D mice compared with WT-D mice, consistent with the development of a spontaneous lung infection. We intranasally administered Pseudomonas aeruginosa to induce lung infection in these mice for 24 h, which led to severe lung leukocytic infiltration and an increase in pro-inflammatory cytokine levels in the BALF. In summary, we established a chronic CFRD-like lung mouse model using the Scnn1b-Tg mice. The model can be used for future studies toward understanding the mechanisms underlying the lung pathophysiology associated with CFRD and developing novel therapeutics.NEW & NOTEWORTHY We established a chronic CFRD-like mouse model using the Scnn1b-Tg transgenic mice overexpressing the epithelial sodium channel β subunit made diabetic by injection of streptozotocin. The results underscore the urgent need to develop novel therapeutics for CF lung disease. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pseudomonas+aeruginosa%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pseudomonas aeruginosa</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cystic+fibrosis-related+diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cystic fibrosis-related diabetes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lung+infection%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lung infection</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22streptozotocin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">streptozotocin</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelial+Sodium+Channels%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelial Sodium Channels/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelial+Sodium+Channels%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelial Sodium Channels/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Transgenic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Transgenic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cystic+Fibrosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cystic Fibrosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cystic+Fibrosis%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cystic Fibrosis/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cystic+Fibrosis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cystic Fibrosis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bronchoalveolar+Lavage+Fluid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bronchoalveolar Lavage Fluid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neutrophils%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neutrophils/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; 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text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Guo L</b>, Zong Y, Yang W, Lin Y, Feng Q, Yu C, Liu X, Li C, Zhang W, Wang R, Li L, Pei Y, Wang H, Liu D, Niu H, Nie L. DCBLD2 deletion increases hyperglycemia and induces vascular remodeling by inhibiting insulin receptor recycling in endothelial cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(9119);'>FEBS J</em> 2024;<b>291</b>:4076-4095. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38872483' target='_blank'>38872483</a> DOI: <a href='https://dx.doi.org/10.1111/febs.17198' target='_blank'>10.1111/febs.17198</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/febs.17198','38872483', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(5);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/febs.17198' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9119);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/22/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1111/febs.17198" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Discoidin, CUB, LCCL domain-containing 2 (DCBLD2) is a type I transmembrane protein with a similar structure to neuropilin, which acts as a co-receptor for certain receptor tyrosine kinases (RTKs). The insulin receptor is an RTK and plays a critical role in endothelial cell function and glycolysis. However, how and whether DCBLD2 regulates insulin receptor activity in endothelial cells is poorly understood. Diabetes was induced through treatment of Dcbld2 global-genome knockout mice and endothelium-specific knockout mice with streptozotocin. Vascular ultrasound, vascular tension test, and hematoxylin and eosin staining were performed to assess endothelial function and aortic remodeling. Glycolytic rate assays, real-time PCR and western blotting were used to investigate the effects of DCBLD2 on glycolytic activity and insulin receptor (InsR)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway in endothelial cells. Co-immunoprecipitation was used to assess the effects of DCBLD2 on insulin receptor endocytosis and recycling. Membrane and cytoplasmic proteins were isolated to determine whether DCBLD2 could affect the localization of the insulin receptor. We found that Dcbld2 deletion exacerbated endothelial dysfunction and vascular remodeling in diabetic mice. Both Dcbld2 knockdown and Dcbld2 deletion inhibited glycolysis and the InsR/PI3K/Akt signaling pathway in endothelial cells. Furthermore, Dcbld2 deletion inhibited insulin receptor recycling. Taken together, Dcbld2 deficiency exacerbated diabetic endothelial dysfunction and vascular remodeling by inhibiting the InsR/PI3K/Akt pathway in endothelial cells through the inhibition of Rab11-dependent insulin receptor recycling. Our data suggest that DCBLD2 is a potential therapeutic target for diabetes and cardiovascular diseases. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DCBLD2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DCBLD2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22endothelial+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">endothelial cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glycolysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glycolysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22insulin+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">insulin receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22vascular+remodeling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">vascular remodeling</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Insulin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Insulin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Insulin%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Insulin/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a 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YAP1-mediated dysregulation of ACE-ACE2 activity augments cardiac fibrosis upon induction of hyperglycemic stress. <em class='incite-journal-name' onclick='ShowInCiteJournal(168095);'>Biochim Biophys Acta Gen Subj</em> 2024;<b>1868</b>:130666. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38955313' target='_blank'>38955313</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbagen.2024.130666' target='_blank'>10.1016/j.bbagen.2024.130666</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbagen.2024.130666','38955313', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbagen.2024.130666' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168095);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.bbagen.2024.130666" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Diabetic stress acts on the cardiac tissue to induce cardiac hypertrophy and fibrosis. Diabetes induced activated renin angiotensin system (RAS) has been reported to play a critical role in mediating cardiac hypertrophy and fibrosis. Angiotensin converting enzyme (ACE) in producing Angiotensin-II, promotes cardiomyocyte hypertrophy and fibrotic damage. ACE2, a recently discovered molecule structurally homologous to ACE, has been reported to be beneficial in reducing the effect of RAS driven pathologies. </div><div class="abstract-label">METHODS</div><div class="abstract-content">In vivo diabetic mouse model was used and co-labelling immunostaining assay have been performed to analyse the fibrotic remodeling and involvement of associated target signaling molecules in mouse heart tissue. For in vitro analyses, qPCR and western blot experiments were performed in different groups for RNA and protein expression analyses. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Fibrosis markers were observed to be upregulated in the diabetic mouse heart tissue as well as in high glucose treated fibroblast and cardiomyocyte cells. Hyperglycemia induced overexpression of YAP1 leads to increased expression of β-catenin (CTNNB1) and ACE with downregulated ACE2 expression. The differential expression of ACE/ACE2 promotes TGFB1-SMAD2/3 pathway in the hyperglycemic cardiomyocyte and fibroblast resulting in increased cardiac fibrotic remodeling. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">In the following study, we have reported YAP1 modulates the RAS signaling pathway by inducing ACE and inhibiting ACE2 activity to augment cardiomyocyte hypertrophy and fibrosis in hyperglycemic condition. Furthermore, we have shown that hyperglycemia induced dysregulation of ACE-ACE2 activity by YAP1 promotes cardiac fibrosis through β-catenin/TGFB1 dependent pathway. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ACE%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ACE</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ACE2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ACE2</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Renin-Angiotensin+System%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Renin-Angiotensin System</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22beta+Catenin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">beta Catenin/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Barco VS</b>, Gallego FQ, Miranda CA, Souza MR, Volpato GT, Damasceno DC. Hyperglycemia influences the cell proliferation and death of the rat endocrine pancreas in the neonatal period. <em class='incite-journal-name' onclick='ShowInCiteJournal(16199);'>Life Sci</em> 2024;<b>351</b>:122854. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38901688' target='_blank'>38901688</a> DOI: <a href='https://dx.doi.org/10.1016/j.lfs.2024.122854' target='_blank'>10.1016/j.lfs.2024.122854</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.lfs.2024.122854','38901688', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.lfs.2024.122854' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16199);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.lfs.2024.122854" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">AIMS</div><div class="abstract-content">To evaluate the cell proliferation and death, and structural morphology of the pancreatic islet cells of the rats with hyperglycemia in the first month of life and compare to those of the control rats. </div><div class="abstract-label">MAIN METHODS</div><div class="abstract-content">Female Sprague-Dawley newborn rats received Streptozotocin (a beta-cytotoxic drug) at birth for diabetes induction. Control and hyperglycemic animals were euthanized on different days of life: 5, 10, 15, and 30. The pancreas was collected and processed for immunohistochemical analysis of cleaved Caspase-3 (cell death), Ki-67 (cell proliferation), PDX-1 (transcription factor responsible for insulin synthesis), and endocrine hormones (insulin, glucagon, and somatostatin). </div><div class="abstract-label">KEY FINDINGS</div><div class="abstract-content">Control females showed a higher percentage (%) of Ki-67-positive(+) cells on D10 and D15, a higher % of insulin+ and somatostatin+ cells on D15 and D30, a lower % of PDX-1+ cells on D10, and a higher % of glucagon+ cells on D10 and D30. Hyperglycemic females showed a lower % of Ki-67+ cells on D15, a higher % of cleaved Caspase-3+ cells on D15, and insulin+ cells on D15 and D30. In the comparison among the experimental groups, the hyperglycemic females showed an increased % of cleaved Caspase-3+ and Ki-67+ cells and a lower % of PDX-1+ cells. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">This study enabled a better understanding of the abnormal pancreas development regarding cellular proliferation, apoptosis, and hormonal synthesis in the neonatal period. Thus, the pancreatic islets of hyperglycemic rats do not reestablish the normal endocrine cell population, and cellular apoptosis overcame the proliferative activity of these cells. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Islet+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Islet cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Murines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Murines</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Newborn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Newborn</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pancreas%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pancreas</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Remodeling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Remodeling</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%2c+Newborn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals, Newborn</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Islets+of+Langerhans%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Islets of Langerhans/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Islets+of+Langerhans%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Islets of Langerhans/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Death%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Death</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucagon%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucagon/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Insulin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Insulin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ki-67+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ki-67 Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caspase+3%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Caspase 3/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Somatostatin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Somatostatin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Trans-Activators%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Trans-Activators</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Homeodomain+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Homeodomain Proteins</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Cázares-Preciado JA</b>, López-Arredondo A, Cruz-Cardenas JA, Luévano-Martínez LA, García-Rivas G, Prado-Garcia H, Brunck MEG. Metabolic features of neutrophilic differentiation of HL-60 cells in hyperglycemic environments. <em class='incite-journal-name' onclick='ShowInCiteJournal(157868);'>BMJ Open Diabetes Res Care</em> 2024;<b>12</b>:e004181. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39122366' target='_blank'>39122366</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11409339' target='_blank'>PMC11409339</a> DOI: <a href='https://dx.doi.org/10.1136/bmjdrc-2024-004181' target='_blank'>10.1136/bmjdrc-2024-004181</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1136/bmjdrc-2024-004181','39122366', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1136/bmjdrc-2024-004181' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(157868);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/bmjdrc' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/12/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1136/bmjdrc-2024-004181" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">INTRODUCTION</div><div class="abstract-content">Chronic hyperglycemia affects neutrophil functions, leading to reduced pathogen killing and increased morbidity. This impairment has been directly linked to increased glycemia, however, how this specifically affects neutrophils metabolism and their differentiation in the bone marrow is unclear and difficult to study. </div><div class="abstract-label">RESEARCH DESIGN AND METHODS</div><div class="abstract-content">We used high-resolution respirometry to investigate the metabolism of resting and activated donor neutrophils, and flow cytometry to measure surface CD15 and CD11b expression. We then used HL-60 cells differentiated towards neutrophil-like cells in standard media and investigated the effect of doubling glucose concentration on differentiation metabolism. We measured the oxygen consumption rate (OCR), and the enzymatic activity of carnitine palmitoyl transferase 1 (CPT1) and citrate synthase during neutrophil-like differentiation. We compared the surface phenotype, functions, and OCR of neutrophil-like cells differentiated under both glucose concentrations. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Donor neutrophils showed significant instability of CD11b and OCR after phorbol 12-myristate 13-acetate stimulation at 3 hours post-enrichment. During HL-60 neutrophil-like cell differentiation, there was a significant increase in surface CD15 and CD11b expression together with the loss of mitochondrial mass. Differentiated neutrophil-like cells also exhibited higher CD11b expression and were significantly more phagocytic. In higher glucose media, we measured a decrease in citrate synthase and CPT1 activities during neutrophil-like differentiation. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">HL-60 neutrophil-like differentiation recapitulated known molecular and metabolic features of human neutrophil differentiation. Increased glucose concentrations correlated with features described in hyperglycemic donor neutrophils including increased CD11b and phagocytosis. We used this model to describe metabolic features of neutrophil-like cell differentiation in hyperglycemia and show for the first time the downregulation of CPT1 and citrate synthase activity, independently of mitochondrial mass. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Type+2+Diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Type 2 Diabetes</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neutrophils%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neutrophils/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HL-60+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HL-60 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD11b+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD11b Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucose%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucose/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carnitine+O-Palmitoyltransferase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carnitine O-Palmitoyltransferase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxygen+Consumption%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxygen Consumption</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lewis+X+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lewis X Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Citrate+(si)-Synthase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Citrate (si)-Synthase/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Goh AR</b>, Park J, Sim AY, Koo BN, Lee YH, Kim JY, Lee JE. Modulating monocyte-derived macrophage polarization in cerebral ischemic injury with hyperglycemia. <em class='incite-journal-name' onclick='ShowInCiteJournal(9062);'>Exp Neurol</em> 2024;<b>378</b>:114824. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38777250' target='_blank'>38777250</a> DOI: <a href='https://dx.doi.org/10.1016/j.expneurol.2024.114824' target='_blank'>10.1016/j.expneurol.2024.114824</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.expneurol.2024.114824','38777250', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.expneurol.2024.114824' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9062);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/25/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.expneurol.2024.114824" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Ischemic stroke (IS), characterized by high mortality rate, occurs owing to diminished or blocked blood flow to the brain. Hyperglycemia (HG) is a major contributor to the risk of IS. HG induces augmented oxidative stress and Blood-Brain Barrier breakdown, which increases the influx of blood-derived myeloid cells into the brain parenchyma. In cerebral ischemia, infiltrating monocytes undergo differentiation into pro-inflammatory or anti-inflammatory macrophages, having a large effect on outcomes of ischemic stroke. In addition, interleukin-4 (IL-4) and interleukin-13 (IL-13) engage in post-ischemia repair by polarizing the infiltrating monocytes into an anti-inflammatory phenotype. In this study, we aimed to determine the effect of phenotypic polarization of monocyte-derived macrophages on the prognosis of IS with HG (HG-IS). We first established a hyperglycemic mouse model using streptozotocin (150 mg/kg) and induced transient middle cerebral artery occlusion. We observed that blood-brain barrier permeability increased in HG-IS mice, as per two-photon live imaging and Evans blue staining. We also confirmed the increased infiltration of monocyte-derived macrophages and the downregulation of anti-inflammatory macrophages related to tissue remodeling after inflammation in HG-IS mice through immunohistochemistry, western blotting, and flow cytometry. We observed phenotypic changes in monocyte-derived macrophages, alleviated infarct volume, and improved motor function in HG-IS mice treated with IL-4 and IL-13. These findings suggest that the modulation of phenotypic changes in monocyte-derived macrophages following IS in hyperglycemic mice may influence ischemic recovery. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-inflammatory+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-inflammatory cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ischemic+stroke%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ischemic stroke</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Monocyte-derived+macrophages%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Monocyte-derived macrophages</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotypical+changes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotypical changes</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Ischemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Ischemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infarction%2c+Middle+Cerebral+Artery%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infarction, Middle Cerebral Artery/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Monocytes%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Monocytes/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Monocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Monocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Monocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Monocytes/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>El-Demerdash FM</b>, Naoom AY, Ghanem NF, Abdel-Daim MM, Kang W. Kiwifruit (Actinidia deliciosa) aqueous extract improves hyperglycemia, testicular inflammation, apoptosis, and tissue structure induced by Streptozotocin via oxidative stress inhibition. <em class='incite-journal-name' onclick='ShowInCiteJournal(22759);'>Tissue Cell</em> 2024;<b>88</b>:102426. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38833941' target='_blank'>38833941</a> DOI: <a href='https://dx.doi.org/10.1016/j.tice.2024.102426' target='_blank'>10.1016/j.tice.2024.102426</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.tice.2024.102426','38833941', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.tice.2024.102426' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(22759);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.tice.2024.102426" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Diabetes mellitus (DM) is a well-known hyperglycemic metabolic condition identified by oxidative stress and biological function disruption. Kiwifruit is a valuable source of polyphenols and vitamin C with great antioxidant, nutritional, and health-promoting effects. Therefore, this study was initiated to explore the antioxidant and anti-hyperglycemic effects of kiwifruit aqueous extract (KFE) against oxidative injury and testis dysfunction in rats with diabetes. Twenty-four male Wistar Albino rats (160-170 g) were divided into four groups: Group 1 served as the control, Group 2 supplemented orally with kiwifruit extract (KFE; 1 g/kg/day) for one month, Group 3 was treated with a single streptozotocin dose (STZ; 50 mg/kg ip), and Group 4 where the diabetic rats were administered with KFE, respectively. According to the results, the GC-MS analysis of KFE revealed several main components with strong antioxidant properties. In diabetic rats, lipid peroxidation and hyperglycemia were accompanied by perturbations in hormone levels and sperm characteristics. Antioxidant enzymes, glutathione content, aminotransferase, phosphatase activities, and protein content were decreased. Furthermore, histology, immunohistochemical PCNA expression, and histochemical analysis of collagen, DNA, RNA, and total protein. were altered in rat testis sections, supporting the changes in biochemistry. Furthermore, diabetic rats supplemented with KFE manifested considerable amendment in all the tested parameters besides improved tissue structure and gene expressions (NF-kB, p53, IL-1β, Bax, IL-10, and Bcl2) relative to the diabetic group. In conclusion, KFE has beneficial effects as it can improve glucose levels and testis function, so it might be used as a complementary therapy in DM. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Actinidia+deliciosa%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Actinidia deliciosa</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biochemical%2fmolecular+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biochemical/molecular analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+peroxidation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid peroxidation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Testicular+dysfunction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Testicular dysfunction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+structure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue structure</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Actinidia%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Actinidia/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Testis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Testis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Testis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Testis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Testis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Testis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Streptozocin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Streptozocin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antioxidants%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antioxidants/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Predheepan D</b>, Salian SR, Uppangala S, Lakshmi R V, Kalthur G, Kovačič B, Adiga SK. Embryos from Prepubertal Hyperglycemic Female Mice Respond Differentially to Oxygen Tension In Vitro. <em class='incite-journal-name' onclick='ShowInCiteJournal(4807);'>Cells</em> 2024;<b>13</b>:954. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38891086' target='_blank'>38891086</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11171876' target='_blank'>PMC11171876</a> DOI: <a href='https://dx.doi.org/10.3390/cells13110954' target='_blank'>10.3390/cells13110954</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/cells13110954','38891086', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(11);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/cells13110954' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4807);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/21/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.3390/cells13110954" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Reduced oxygen during embryo culture in human ART prevents embryo oxidative stress. Oxidative stress is also the major mechanism by which maternal diabetes impairs embryonic development. This study employed induced hyperglycemia prepubertal mice to mimic childhood diabetes to understand the effects of varying oxygen tension during in vitro embryonic development. The oocytes were fertilized and cultured at low (≈5%) oxygen (LOT) or atmospheric (≈20%) oxygen tension (HOT) for up to 96 h. Embryo development, apoptosis in blastocysts, inner cell mass (ICM) outgrowth proliferation, and Hif1α expression were assessed. Though the oocyte quality and meiotic spindle were not affected, the fertilization rate (94.86 ± 1.18 vs. 85.17 ± 2.81), blastocyst rate (80.92 ± 2.92 vs. 69.32 ± 2.54), and ICM proliferation ability (51.04 ± 9.22 vs. 17.08 ± 3.05) of the hyperglycemic embryos were significantly higher in the LOT compared to the HOT group. On the other hand, blastocysts from the hyperglycemic group, cultured at HOT, had a 1.5-fold increase in apoptotic cells compared to the control and lower Hif1α transcripts in ICM outgrowths compared to the LOT. Increased susceptibility of embryos from hyperglycemic mice to higher oxygen tension warrants the need to individualize the conditions for embryo culture systems in ART clinics, particularly when an endogenous maternal pathology affects the ovarian environment. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22embryo+development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">embryo development</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22oxygen+tension%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">oxygen tension</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prepubertal+hyperglycemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prepubertal hyperglycemia</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxygen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxygen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxygen%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxygen/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Embryonic+Development%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Embryonic Development/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blastocyst%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blastocyst/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypoxia-Inducible+Factor+1%2c+alpha+Subunit%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypoxia-Inducible Factor 1, alpha Subunit/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypoxia-Inducible+Factor+1%2c+alpha+Subunit%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypoxia-Inducible Factor 1, alpha Subunit/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Embryo%2c+Mammalian%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Embryo, Mammalian/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+and+Engineering+Research+Board%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">EMR/2016/005737 Science and Engineering Research Board</a></li></ul> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Lee KS</b>, Yoon SH, Hwang I, Ma JH, Yang E, Kim RH, Kim E, Yu JW. Hyperglycemia enhances brain susceptibility to lipopolysaccharide-induced neuroinflammation via astrocyte reprogramming. <em class='incite-journal-name' onclick='ShowInCiteJournal(14647);'>J Neuroinflammation</em> 2024;<b>21</b>:137. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38802820' target='_blank'>38802820</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131277' target='_blank'>PMC11131277</a> DOI: <a href='https://dx.doi.org/10.1186/s12974-024-03136-1' target='_blank'>10.1186/s12974-024-03136-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s12974-024-03136-1','38802820', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(12);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s12974-024-03136-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14647);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/17/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/29/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1186/s12974-024-03136-1" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Hyperglycemia has been shown to modulate the immune response of peripheral immune cells and organs, but the impact of hyperglycemia on neuroinflammation within the brain remains elusive. In the present study, we provide evidences that streptozotocin (STZ)-induced hyperglycemic condition in mice drives a phenotypic switch of brain astrocytes to a proinflammatory state, and increases brain vulnerability to mild peripheral inflammation. In particular, we found that hyperglycemia led to a significant increase in the astrocyte proliferation as determined by flow cytometric and immunohistochemical analyses of mouse brain. The increased astrocyte proliferation by hyperglycemia was reduced by Glut1 inhibitor BAY-876. Transcriptomic analysis of isolated astrocytes from Aldh1l1CreERT2;tdTomato mice revealed that peripheral STZ injection induced astrocyte reprogramming into proliferative, and proinflammatory phenotype. Additionally, STZ-induced hyperglycemic condition significantly enhanced the infiltration of circulating myeloid cells into the brain and the disruption of blood-brain barrier in response to mild lipopolysaccharide (LPS) administration. Systemic hyperglycemia did not alter the intensity and sensitivity of peripheral inflammation in mice to LPS challenge, but increased the inflammatory potential of brain microglia. In line with findings from mouse experiments, a high-glucose environment intensified the LPS-triggered production of proinflammatory molecules in primary astrocyte cultures. Furthermore, hyperglycemic mice exhibited a significant impairment in cognitive function after mild LPS administration compared to normoglycemic mice as determined by novel object recognition and Y-maze tasks. Taken together, these results demonstrate that hyperglycemia directly induces astrocyte reprogramming towards a proliferative and proinflammatory phenotype, which potentiates mild LPS-triggered inflammation within brain parenchymal regions. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Astrocytes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Astrocytes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+function%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive function</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA-sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA-sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Astrocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Astrocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Astrocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Astrocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Astrocytes%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Astrocytes/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/pathology</a></li><li><a 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effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellular+Reprogramming%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellular Reprogramming/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Transgenic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Transgenic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2022R1A2C2007569 National Research Foundation of Korea</a></li></ul> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Zang L</b>, Saitoh S, Katayama K, Zhou W, Nishimura N, Shimada Y. A zebrafish model of diabetic nephropathy shows hyperglycemia, proteinuria and activation of the PI3K/Akt pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(7809);'>Dis Model Mech</em> 2024;<b>17</b>:dmm050438. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38747698' target='_blank'>38747698</a> DOI: <a href='https://dx.doi.org/10.1242/dmm.050438' target='_blank'>10.1242/dmm.050438</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1242/dmm.050438','38747698', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(13);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1242/dmm.050438' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7809);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/03/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/30/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1242/dmm.050438" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Diabetic nephropathy (DN), as a complication of diabetes, is a substantial healthcare challenge owing to the high risk of morbidity and mortality involved. Although significant progress has been made in understanding the pathogenesis of DN, more efficient models are required to develop new therapeutics. Here, we created a DN model in zebrafish by crossing diabetic Tg(acta1:dnIGF1R-EGFP) and proteinuria-tracing Tg(l-fabp::VDBP-GFP) lines, named zMIR/VDBP. Overfed adult zMIR/VDBP fish developed severe hyperglycemia and proteinuria, which were not observed in wild-type zebrafish. Renal histopathology revealed human DN-like characteristics, such as glomerular basement membrane thickening, foot process effacement and glomerular sclerosis. Glomerular dysfunction was restored upon calorie restriction. RNA sequencing analysis demonstrated that DN zebrafish kidneys exhibited transcriptional patterns similar to those seen in human DN pathogenesis. Notably, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was activated, a phenomenon observed in the early phase of human DN. In addition, metformin improved hyperglycemia and proteinuria in DN zebrafish by modulating Akt phosphorylation. Our results indicate that zMIR/VDBP fish are suitable for elucidating the mechanisms underlying human DN and could be a powerful tool for therapeutic discovery. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+nephropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic nephropathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glomerular+hypertrophy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glomerular hypertrophy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proteinuria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proteinuria</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Type+2+diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Type 2 diabetes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zebrafish%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zebrafish</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zebrafish%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zebrafish</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proteinuria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proteinuria</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphatidylinositol+3-Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphatidylinositol 3-Kinases/metabolism</a></li><li><a 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for the Promotion of Science</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mie+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mie University</a></li></ul> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Ren X</b>, Cui Z, Zhang Q, Su Z, Xu W, Wu J, Jiang H. JunB condensation attenuates vascular endothelial damage under hyperglycemic condition. <em class='incite-journal-name' onclick='ShowInCiteJournal(14506);'>J Mol Cell Biol</em> 2024;<b>15</b>:mjad072. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38140943' target='_blank'>38140943</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11080659' target='_blank'>PMC11080659</a> DOI: <a href='https://dx.doi.org/10.1093/jmcb/mjad072' target='_blank'>10.1093/jmcb/mjad072</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/jmcb/mjad072','38140943', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(14);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1093/jmcb/mjad072' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14506);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/20/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/23/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/22/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/24/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1093/jmcb/mjad072" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Endothelial damage is the initial and crucial factor in the occurrence and development of vascular complications in diabetic patients, contributing to morbidity and mortality. Although hyperglycemia has been identified as a damaging effector, the detailed mechanisms remain elusive. In this study, identified by ATAC-seq and RNA-seq, JunB reverses the inhibition of proliferation and the promotion of apoptosis in human umbilical vein endothelial cells treated with high glucose, mainly through the cell cycle and p53 signaling pathways. Furthermore, JunB undergoes phase separation in the nucleus and in vitro, mediated by its intrinsic disordered region and DNA-binding domain. Nuclear localization and condensation behaviors are required for JunB-mediated proliferation and apoptosis. Thus, our study uncovers the roles of JunB and its coacervation in repairing vascular endothelial damage caused by high glucose, elucidating the involvement of phase separation in diabetes and diabetic endothelial dysfunction. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22JunB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">JunB</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22endothelial+damage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">endothelial damage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hyperglycemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hyperglycemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22phase+separation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">phase separation</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Cycle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Cycle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Nucleus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Nucleus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endothelium%2c+Vascular%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endothelium, Vascular/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endothelium%2c+Vascular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endothelium, Vascular/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucose%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucose/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucose%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucose/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Human+Umbilical+Vein+Endothelial+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Human Umbilical Vein Endothelial Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Suppressor+Protein+p53%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Suppressor Protein p53/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">32090043 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Key+Research+and+Development+Program+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2017YFC0840101 National Key Research and Development Program of China</a></li></ul> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Vélez EJ</b>, Schnebert S, Goguet M, Balbuena-Pecino S, Dias K, Beauclair L, Fontagné-Dicharry S, Véron V, Depincé A, Beaumatin F, Herpin A, Seiliez I. Chaperone-mediated autophagy protects against hyperglycemic stress. <em class='incite-journal-name' onclick='ShowInCiteJournal(3190);'>Autophagy</em> 2024;<b>20</b>:752-768. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37798944' target='_blank'>37798944</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11062381' target='_blank'>PMC11062381</a> DOI: <a href='https://dx.doi.org/10.1080/15548627.2023.2267415' target='_blank'>10.1080/15548627.2023.2267415</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1080%2f15548627.2023.2267415%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1080%2f15548627.2023.2267415')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15548627.2023.2267415','37798944', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15548627.2023.2267415' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3190);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/04/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/02/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/07/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1080/15548627.2023.2267415" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homeostasis and metabolism, and whose defects have been associated with several human pathologies. While CMA has been well described in mammals, functional evidence has only recently been documented in fish, opening up new perspectives to tackle this function under a novel angle. Now we propose to explore CMA functions in the rainbow trout (RT, Oncorhynchus mykiss), a fish species recognized as a model organism of glucose intolerance and characterized by the presence of two paralogs of the CMA-limiting factor Lamp2A (lysosomal associated membrane protein 2A). To this end, we validated a fluorescent reporter (KFERQ-PA-mCherry1) previously used to track functional CMA in mammalian cells, in an RT hepatoma-derived cell line (RTH-149). We found that incubation of cells with high-glucose levels (HG, 25 mM) induced translocation of the CMA reporter to lysosomes and/or late endosomes in a KFERQ- and Lamp2A-dependent manner, as well as reduced its half-life compared to the control (5 mM), thus demonstrating increased CMA flux. Furthermore, we observed that activation of CMA upon HG exposure was mediated by generation of mitochondrial reactive oxygen species, and involving the antioxidant transcription factor Nfe2l2/Nrf2 (nfe2 like bZIP transcription factor 2). Finally, we demonstrated that CMA plays an important protective role against HG-induced stress, primarily mediated by one of the two RT Lamp2As. Together, our results provide unequivocal evidence for CMA activity existence in RT and highlight both the role and regulation of CMA during glucose-related metabolic disorders.Abbreviations: AREs: antioxidant response elements; CHC: α-cyano -4-hydroxycinnamic acid; Chr: chromosome; CMA: chaperone-mediated autophagy; CT: control; DMF: dimethyl fumarate; Emi: endosomal microautophagy; HG: high-glucose; HMOX1: heme oxygenase 1; H2O2: hydrogen peroxide; KFERQ: lysine-phenylalanine-glutamate-arginine-glutamine; LAMP1: lysosomal associated membrane protein 1; LAMP2A: lysosomal associated membrane protein 2A; MCC: Manders' correlation coefficient; Manders' correlation coefficient Mo: morpholino oligonucleotide; NAC: N-acetyl cysteine; NFE2L2/NRF2: NFE2 like bZIP transcription factor 2; PA-mCherry: photoactivable mCherry; PCC: Pearson's correlation coefficient; ROS: reactive oxygen species; RT: rainbow trout; siRNAs: small interfering RNAs; SOD: superoxide dismutase; Tsg101: tumor susceptibility 101; TTFA: 2-thenoyltrifluoroacetone; WGD: whole-genome duplication. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CMA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CMA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lamp2A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lamp2A</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NFE2L2%2fNRF2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NFE2L2/NRF2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22fish%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">fish</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glucose+intolerance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glucose intolerance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metabolism</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chaperone-Mediated+Autophagy%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chaperone-Mediated Autophagy/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chaperone-Mediated+Autophagy%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chaperone-Mediated Autophagy/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chaperone-Mediated+Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chaperone-Mediated Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lysosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lysosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lysosomes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lysosomes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oncorhynchus+mykiss%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oncorhynchus mykiss/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucose%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucose/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lysosomal-Associated+Membrane+Protein+2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lysosomal-Associated Membrane Protein 2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lysosomal-Associated+Membrane+Protein+2%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lysosomal-Associated Membrane Protein 2/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Chaperones%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Chaperones/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Wang F</b>, Han S, Fang L, Lin X. A fetal rat model of ventricular noncompaction caused by intrauterine hyperglycemia. <em class='incite-journal-name' onclick='ShowInCiteJournal(4646);'>Cardiovasc Pathol</em> 2024;<b>69</b>:107601. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38072092' target='_blank'>38072092</a> DOI: <a href='https://dx.doi.org/10.1016/j.carpath.2023.107601' target='_blank'>10.1016/j.carpath.2023.107601</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.carpath.2023.107601','38072092', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.carpath.2023.107601' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4646);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/cvp/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/07/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/17/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/05/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/25/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1016/j.carpath.2023.107601" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">This study aims to develop a fetal rat model of ventricular noncompaction (NVM) using streptozotocin (STZ)-induced gestational hyperglycemia and compare it with a retinoic acid (RA) model. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Female SD rats were categorized into STZ, RA, and normal control (NC) groups. The STZ group was given a high-fat diet pre-pregnancy and 35 mg/kg of 2% STZ postpregnancy. The RA group received a 90 mg/kg dose of RA on day 13 postpregnancy. Embryonic myocardial morphology was analyzed through HE staining, and embryonic cardiomyocyte ultrastructures were studied using electron microscopy. Diagnoses of NVM were based on a ratio of noncompact myocardium (N) to compact myocardium (C) >1.4, accompanied by thick myocardial trabeculae and a thin myocardial compaction layer. Kruskal-Wallis test determined N/C ratio differences among groups. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Both STZ and RA groups displayed significant NVM characteristics. The left ventricular (LV) N/C in the STZ, RA, and NC groups were 1.983 (1.423-3.527), 1.640 (1.197-2.895), and 0.927 (0.806-1.087), respectively, with a statistically significant difference (P<0.001). The right ventricular (RV) N/C in the STZ, RA, and NC groups were 2.097 (1.364-3.081), 1.897 (1.337-2.662), and 0.869 (0.732-1.022), respectively, with a significant difference (P<0.001). Electron microscopy highlighted marked endoplasmic reticulum swelling in embryonic cardiomyocytes from both STZ and RA groups. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Our model underscores the pivotal role of an adverse intrauterine developmental environment in the onset of NVM. This insight holds significant implications for future studies exploring the pathogenesis of NVM. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animal+model%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animal model</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Heart+development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Heart development</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Maternal+hyperglycemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Maternal hyperglycemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retinoic+acid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retinoic acid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Streptozotocin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Streptozotocin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22noncompaction+of+ventricular+myocardium%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">noncompaction of ventricular myocardium</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pregnancy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pregnancy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Heart+Ventricles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Heart Ventricles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardium%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardium/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tretinoin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tretinoin</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Ozaki T</b>, Fu HY, Onishi K, Yokoyama S, Fujita T, Tobiume A, Sofue T, Akimitsu K, Minamino T. Partial replacement of d-glucose with d-allose ameliorates peritoneal injury and hyperglycaemia induced by peritoneal dialysis fluid in rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(169440);'>Perit Dial Int</em> 2024;<b>44</b>:125-132. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37525525' target='_blank'>37525525</a> DOI: <a href='https://dx.doi.org/10.1177/08968608231184354' target='_blank'>10.1177/08968608231184354</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1177/08968608231184354','37525525', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1177/08968608231184354' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169440);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/02/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1177/08968608231184354" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Peritoneal dialysis (PD) is a crucial dialysis method for treating end-stage kidney disease. However, its use is restricted due to high glucose-induced peritoneal injury and hyperglycaemia, particularly in patients with diabetes mellitus. In this study, we investigated whether partially replacing d-glucose with the rare sugar d-allose could ameliorate peritoneal injury and hyperglycaemia induced by peritoneal dialysis fluid (PDF). </div><div class="abstract-label">METHODS</div><div class="abstract-content">Rat peritoneal mesothelial cells (RPMCs) were exposed to a medium containing d-glucose or d-glucose partially replaced with different concentrations of d-allose. Cell viability, oxidative stress and cytokine production were evaluated. Sprague-Dawley (SD) rats were administrated saline, a PDF containing 4% d-glucose (PDF-G4.0%) or a PDF containing 3.6% d-glucose and 0.4% d-allose (PDF-G3.6%/A0.4%) once a day for 4 weeks. Peritoneal injury and PD efficiency were assessed using immuno-histological staining and peritoneal equilibration test, respectively. Blood glucose levels were measured over 120 min following a single injection of saline or PDFs to 24-h fasted SD rats. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">In RPMCs, the partial replacement of d-glucose with d-allose increased cell viability and decreased oxidative stress and cytokine production compared to d-glucose alone. Despite the PDF-G3.6%/A0.4% having a lower d-glucose concentration compared to PDF-G4.0%, there were no significant changes in osmolality. When administered to SD rats, the PDF-G3.6%/A0.4% suppressed the elevation of peritoneal thickness and blood d-glucose levels induced by PDF-G4.0%, without impacting PD efficiency. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Partial replacement of d-glucose with d-allose ameliorated peritoneal injury and hyperglycaemia induced by high concentration of d-glucose in PDF, indicating that d-allose could be a potential treatment option in PD. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22d-Allose%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">d-Allose</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22peritoneal+dialysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">peritoneal dialysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rare+sugar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rare sugar</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peritoneal+Dialysis%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peritoneal Dialysis/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peritoneal+Dialysis%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peritoneal Dialysis/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dialysis+Solutions%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dialysis Solutions/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peritoneum%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peritoneum/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucose%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucose</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Li SY</b>, Zhao N, Wei D, Pu N, Hao XN, Huang JM, Peng GH, Tao Y. Ferroptosis in the ageing retina: A malevolent fire of diabetic retinopathy. <em class='incite-journal-name' onclick='ShowInCiteJournal(1615);'>Ageing Res Rev</em> 2024;<b>93</b>:102142. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38030091' target='_blank'>38030091</a> DOI: <a href='https://dx.doi.org/10.1016/j.arr.2023.102142' target='_blank'>10.1016/j.arr.2023.102142</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.arr.2023.102142','38030091', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.arr.2023.102142' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(1615);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/02/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/08/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/01/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.arr.2023.102142" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Ageing retina is prone to ferroptosis due to the iron accumulation and impaired efficiency of intracellular antioxidant defense system. Ferroptosis acts as a cell death modality that is characterized by the iron-dependent accumulation of lipid peroxidation. Ferroptosis is distinctively different from other types of regulated cell death (RCD) at the morphological, biochemical, and genetic levels. Diabetic retinopathy (DR) is a common microvascular complication of diabetes. Its prevalence and severity increase progressively with age. Recent reports have shown that ferroptosis is implicated in the pathophysiology of DR. Under hyperglycemia condition, the endothelial cell and retinal pigment epithelium (RPE) cell will undergo ferroptosis, which contributes to the increased vascular permeability and the disrupted blood retinal barrier (BRB). The underlying etiology of DR can be attributed to the impaired BRB integrity and subsequent damages of the neurovascular units. In the absence of timely intervention, the compromised BRB can ultimately cause profound visual impairments. In particular, the ageing retina is vulnerable to ferroptosis, and hyperglycemia will accelerate the progression of this pathological process. In this article, we discuss the contributory role of ferroptosis in DR pathogenesis, and summarize recent therapeutic trials that targeting the ferroptosis. Further study on the ferroptosis mediated damage would enrich our knowledge of DR pathology, and promote the development of clinical treatment for this degenerative retinopathy. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ageing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ageing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+retinopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic retinopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retinal+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retinal degeneration</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Retinopathy%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Retinopathy/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Retinopathy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Retinopathy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Retinopathy%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Retinopathy/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Iron%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Iron/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retina%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retina/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Sun D</b>, Li S, Chen S, Zhang S, Gu Q, Shen Y, Wei F, Wang N. TRIM25 inhibition attenuates inflammation, senescence, and oxidative stress in microvascular endothelial cells induced by hyperglycemia. <em class='incite-journal-name' onclick='ShowInCiteJournal(9892);'>Graefes Arch Clin Exp Ophthalmol</em> 2024;<b>262</b>:81-91. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37367995' target='_blank'>37367995</a> DOI: <a href='https://dx.doi.org/10.1007/s00417-023-06160-8' target='_blank'>10.1007/s00417-023-06160-8</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00417-023-06160-8','37367995', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(19);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00417-023-06160-8' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9892);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/18/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/06/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/28/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1007/s00417-023-06160-8" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">PURPOSES</div><div class="abstract-content">This work aimed to assess the possible role of TRIM25 in regulating hyperglycemia-induced inflammation, senescence, and oxidative stress in retinal microvascular endothelial cells, all of which exert critical roles in the pathological process of diabetic retinopathy. </div><div class="abstract-label">METHODS</div><div class="abstract-content">The effects of TRIM25 were investigated using streptozotocin-induced diabetic mice, human primary retinal microvascular endothelial cells cultured in high glucose, and adenoviruses for TRIM25 knockdown and overexpression. TRIM25 expression was evaluated by western blot and immunofluorescence staining. Inflammatory cytokines were detected by western blot and quantitative real-time PCR. Cellular senescence level was assessed by detecting senescent marker p21 and senescence-associated-β-galactosidase activity. The oxidative stress state was accessed by detecting reactive oxygen species and mitochondrial superoxide dismutase. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">TRIM25 expression is elevated in the endothelial cells of the retinal fibrovascular membrane from diabetic patients compared with that of the macular epiretinal membrane from non-diabetic patients. Moreover, we have also observed a significant increase in TRIM25 expression in diabetic mouse retina and retinal microvascular endothelial cells under hyperglycemia. TRIM25 knockdown suppressed hyperglycemia-induced inflammation, senescence, and oxidative stress in human primary retinal microvascular endothelial cells while TRIM25 overexpression further aggregates those injuries. Further investigation revealed that TRIM25 promoted the inflammatory responses mediated by the TNF-α/NF-κB pathway and TRIM25 knockdown improved cellular senescence by increasing SIRT3. However, TRIM25 knockdown alleviated the oxidative stress independent of both SIRT3 and mitochondrial biogenesis. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Our study proposed TRIM25 as a potential therapeutic target for the protection of microvascular function during the progression of diabetic retinopathy. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+retinopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic retinopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Senescence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Senescence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TRIM25%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TRIM25</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" 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Ligases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ubiquitin-Protein+Ligases%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ubiquitin-Protein Ligases/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+and+Technology+Research+Project+of+Songjiang+District%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2020SJ300 Science and Technology Research Project of Songjiang District</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Key+R%26D+Program+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2016YFC0904800 National Key R&D Program of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Key+R%26D+Program+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2019YFC0840607 National Key R&D Program of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Science+and+Technology+Major+Project+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2017ZX09304010 National Science and Technology Major Project of China</a></li></ul> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Muhammed TM</b>, Jalil AT, Taher WM, Aminov Z, Alsaikhan F, Ramírez-Coronel AA, Ramaiah P, Farhood B. The Effects of Apigenin in the Treatment of Diabetic Nephropathy: A Systematic Review of Non-clinical Studies. <em class='incite-journal-name' onclick='ShowInCiteJournal(16958);'>Mini Rev Med Chem</em> 2024;<b>24</b>:341-354. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38282447' target='_blank'>38282447</a> DOI: <a href='https://dx.doi.org/10.2174/1389557523666230811092423' target='_blank'>10.2174/1389557523666230811092423</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.2174/1389557523666230811092423','38282447', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(20);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.2174/1389557523666230811092423' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16958);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/08/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.2174/1389557523666230811092423" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">PURPOSE</div><div class="abstract-content">Diabetes is one of the important and growing diseases in the world. Among the most common diabetic complications are renal adverse effects. The use of apigenin may prevent the development and progression of diabetes-related injuries. The current study aims to review the effects of apigenin in the treatment of diabetic nephropathy. </div><div class="abstract-label">METHODS</div><div class="abstract-content">In this review, a systematic search was performed based on PRISMA guidelines for obtaining all relevant studies on "the effects of apigenin against diabetic nephropathy" in various electronic databases up to September 2022. Ninety-one articles were obtained and screened in accordance with the predefined inclusion and exclusion criteria. Seven eligible articles were finally included in this review. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The experimental findings revealed that hyperglycemia led to the decreased cell viability of kidney cells and body weight loss and an increased kidney weight of rats; however, apigenin administration had a reverse effect on these evaluated parameters. It was also found that hyperglycemia could induce alterations in the biochemical and renal function-related parameters as well as histopathological injuries in kidney cells or tissue; in contrast, the apigenin administration could ameliorate the hyperglycemia-induced renal adverse effects. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The results indicated that the use of apigenin could mitigate diabetes-induced renal adverse effects, mainly through its antioxidant, anti-apoptotic, and anti-inflammatory activities. Since the findings of this study are based on experimental studies, suggesting the use of apigenin (as a nephroprotective agent) against diabetic nephropathy requires further clinical studies. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apigenin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apigenin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">diabetes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nephropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nephropathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22oxidative+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">oxidative stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22systematic+review.%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">systematic review.</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Nephropathies%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Nephropathies/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apigenin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apigenin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apigenin%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apigenin/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apigenin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apigenin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/prevention & control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prince+Satam+bin+Abdulaziz+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PSAU/2023/R/1444 Prince Satam bin Abdulaziz University</a></li></ul> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Bao C</b>, Liu X, Li Y, Yang J, Wei F, Gong Y, Ma Z, Liu J. Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study. <em class='incite-journal-name' onclick='ShowInCiteJournal(8384);'>Endocr J</em> 2023;<b>70</b>:1131-1140. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37914275' target='_blank'>37914275</a> DOI: <a href='https://dx.doi.org/10.1507/endocrj.ej23-0211' target='_blank'>10.1507/endocrj.ej23-0211</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1507/endocrj.ej23-0211','37914275', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1507/endocrj.ej23-0211' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8384);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/endocrj' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/03/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1507/endocrj.ej23-0211" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">To examine the association between prediabetes/type 2 diabetes mellitus (T2DM) and hippocampal subfields and to investigate the effects of glycemic control (HbA1c and FBG)/diabetes duration on the volume of hippocampal subfields in T2DM patients. This cross-sectional study included 268 participants from Tianjin Union Medical Center between August 2019 and July 2022. The participants were divided into three groups: T2DM, prediabetes and no diabetes. All participants underwent brain MRI examination on a 3T MRI scanner. FreeSurfer was performed to segment hippocampus automatically based on T1 MPRAGE images. The relationships between glycemic status/glycemic control/diabetes duration and hippocampal subfield volumes were estimated by multiple linear regression analysis/generalized additive modeling (GAM). Among all participants, 76 (28.36%) had prediabetes, and 96 (35.82%) had T2DM. In multi-adjusted linear regression models, those with prediabetes had a significantly lower volume of bilateral parasubiculum (βright = -5.540; βleft = -6.497). Those with diabetes had lower volume of parasubiculum (βleft = -7.868), presubiculum-head (βleft = -6.244) and fimbria (βleft = -7.187). We did not find relationship between diabetes duration and hippocampal subfield volumes. In stratified analysis, long duration with high FBG related with lower volume of right fimbria (βright = -15.583). Long duration with high HbA1c related with lower volume of presubiculum-head (βright = -19.693), subiculum-head (βright = -28.303), subiculum-body (βleft = -38.599), CA1-head (βright = -62.300, βleft = -47.922), CA1-body (βright = -19.043), CA4-body (βright = -14.392), GC-ML-DG-head (βright = -20.521), GC-ML-DG-body (βright = -16.293, βleft = -12.799), molecular_layer_HP-head (βright = -44.202, βleft = -26.071) and molecular_layer_HP-body, (βright = -31.368), hippocampal_tail (βleft = -80.073). Prediabetes related with lower bilateral parasubiculum volume, and T2DM related with lower left parasubiculum, presubiculum-head and fimbria. T2DM with chronic poor glycemic control had lower volume in multiple hippocampal subregions. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucose+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucose control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Regional+hippocampus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Regional hippocampus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Type+2+diabetes+mellitus+(T2DM)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Type 2 diabetes mellitus (T2DM)</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cross-Sectional+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cross-Sectional Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Type+2%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Type 2/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Type+2%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Type 2/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prediabetic+State%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prediabetic State/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prediabetic+State%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prediabetic State/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycated+Hemoglobin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycated Hemoglobin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycemic+Control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycemic Control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atrophy%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atrophy/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Shen T</b>, Zhao J, Li W, Wang X, Gao Y, Wang Z, Hu S, Cai J. Hypertension and hyperglycaemia are positively correlated with local invasion of early cervical cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(9342);'>Front Endocrinol (Lausanne)</em> 2023;<b>14</b>:1280060. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38152132' target='_blank'>38152132</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10752498' target='_blank'>PMC10752498</a> DOI: <a href='https://dx.doi.org/10.3389/fendo.2023.1280060' target='_blank'>10.3389/fendo.2023.1280060</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fendo.2023.1280060','38152132', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(22);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fendo.2023.1280060' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fendo.2023.1280060');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9342);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.frontiersin.org/people/login' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/19/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/28/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/29/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.3389/fendo.2023.1280060" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">Metabolic disorders are involved in the development of numerous cancers, but their association with the progression of cervical cancer is unclear. This study aims to investigate the association between metabolic disorders and the pathological risk factors and survival in patients with early cervical cancer. </div><div class="abstract-label">Methods</div><div class="abstract-content">Patients with FIGO IB1 (2009) primary cervical cancer who underwent radical hysterectomy and systematic pelvic lymph node dissection at our institution from October 2014 to December 2017 were included retrospectively. Clinical data regarding the metabolic syndrome and surgical pathology of the patient were collected. The correlations between metabolic disorders (hypertension, hyperglycemia, and obesity) and clinicopathological characteristics as well as survival after surgery were analyzed. </div><div class="abstract-label">Results</div><div class="abstract-content">The study included 246 patients with clinical IB1 cervical cancer, 111 (45.1%) of whom had at least one of the comorbidities of hypertension, obesity, or hyperglycemia. Hypertension was positively correlated with parametrial invasion and poorly differentiated histology; hyperglycemia was positively correlated with stromal invasion; obesity was negatively associated with lymph node metastasis; but arbitrary disorder did not show any correlation with pathologic features. Hypertension was an independent risk factor for parametrial invasion (OR=6.54, 95% CI: 1.60-26.69); hyperglycemia was an independent risk factor for stromal invasion (OR=2.05, 95% CI: 1.07-3.95); and obesity was an independent protective factor for lymph node metastasis (OR=0.07, 95% CI: 0.01-0.60). Moreover, the patients with hypertension had a significantly lower 5-year OS rate (70.0% vs. 95.3%, P<0.0001) and a significantly lower 5-year PFS rate than those without hypertension (70.0% vs. 91.2%, P=0.010). </div><div class="abstract-label">Conclusion</div><div class="abstract-content">Hypertension and hyperglycemia are positively associated with local invasion of early cervical cancer, which need to be verified in multi-center, large scale studies. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cervical+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cervical cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hyperglycemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hyperglycemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hypertension%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hypertension</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metabolic+disorders%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metabolic disorders</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22obesity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">obesity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pathological+characteristics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pathological characteristics</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uterine+Cervical+Neoplasms%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uterine Cervical Neoplasms/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uterine+Cervical+Neoplasms%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uterine Cervical Neoplasms/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uterine+Cervical+Neoplasms%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uterine Cervical Neoplasms/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphatic+Metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphatic Metastasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Staging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Staging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypertension%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypertension/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypertension%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypertension/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypertension%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypertension/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; 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Protecting mechanism of <i>Swietenia macrophylla</i> ethanol extract nanoparticle on streptozotocin induced renal damage in rat. <em class='incite-journal-name' onclick='ShowInCiteJournal(168240);'>Open Vet J</em> 2023;<b>13</b>:1623-1630. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38292712' target='_blank'>38292712</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824090' target='_blank'>PMC10824090</a> DOI: <a href='https://dx.doi.org/10.5455/ovj.2023.v13.i12.12' target='_blank'>10.5455/ovj.2023.v13.i12.12</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.5455/ovj.2023.v13.i12.12','38292712', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.5455/ovj.2023.v13.i12.12' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/c8baea7c5310de712d22c0c07f1a513d/OpenVetJ-13-1623.PMC10824090.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.5455/ovj.2023.v13.i12.12');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168240);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/04/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/18/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/01/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.5455/ovj.2023.v13.i12.12" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">Hyperglycemia increases reactive oxygen species (ROS), which contributes to diabetic complications such as kidney cell damage. Antioxidant administration could inhibit ROS and kidney cell damage commonly seen in hyperglycemia. </div><div class="abstract-label">Aim</div><div class="abstract-content">We want to demonstrate that the antioxidant properties of Swietenia macrophylla ethanol extract nanoparticles can prevent kidney cell damage brought on by streptozotocin (STZ) in the current investigation. </div><div class="abstract-label">Methods</div><div class="abstract-content">This study employs high-energy ball milling to produce nanoparticles from S. macrophylla extract. Additionally, dynamic light scattering (DLS) is utilized to characterize the nanoparticle sizes of the S. macrophylla ethanol extract. Five groups, each consisting of 8 rats, were formed from 40 rats. Control rats received distilled water, the diabetic rats were administered STZ injections, while S. macrophylla rats were given S. macrophylla extract nanoparticles orally and STZ injection. After the trial, blood from a rat was drawn intracardially to check the levels of blood urea nitrogen (BUN) and creatinine. The levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA) were then assessed in kidney tissue samples. Histological alterations were evaluated in kidney section samples. </div><div class="abstract-label">Results</div><div class="abstract-content">A DLS analysis estimated the size of the S. macrophylla ethanol extract nanoparticles to be about 91.50 ± 23.06 nm. BUN and creatinine levels were significantly raised after STZ treatment. STZ significantly decreased SOD and GPx levels in kidney tissue while raising MDA levels (p < 0.05). Swietenia macrophylla ethanol extract nanoparticle caused the decreased levels of BUN and creatinine in blood to normal levels (p < 0.05), indicating that S. macrophylla ethanol extract prevented the STZ-induced kidney cell damage. Additionally, S. macrophylla nanoparticles significantly raise GPx and SOD levels in kidney tissue while lowering MDA levels (p < 0.05). These actions are thought to have prevented kidney histological alterations (degeneration and necrosis) in diabetic rats. </div><div class="abstract-label">Conclusion</div><div class="abstract-content">According to these results, the anti-oxidative stress properties of S. macrophylla nanoparticles make them potentially effective nephroprotective therapies for STZ-induced kidney cell damage. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antioxidant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antioxidant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nephroprotector%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nephroprotector</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Swietenia+macrophylla%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Swietenia macrophylla</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antioxidants%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antioxidants/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Creatinine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Creatinine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ethanol%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ethanol/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fveterinary%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/veterinary</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Meliaceae%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Meliaceae</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Streptozocin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Streptozocin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Superoxide+Dismutase%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Superoxide Dismutase/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Kotova DA</b>, Ivanova AD, Pochechuev MS, Kelmanson IV, Khramova YV, Tiaglik A, Sudoplatov MA, Trifonova AP, Fedotova A, Morozova K, Katrukha VA, Sergeeva AD, Raevskii RI, Pestriakova MP, Solotenkov MA, Stepanov EA, Tsopina AS, Moshchenko AA, Shestopalova M, Zalygin A, Fedotov IV, Fedotov AB, Oleinikov V, Belousov VV, Semyanov A, Brazhe N, Zheltikov AM, Bilan DS. Hyperglycemia exacerbates ischemic stroke not through increased generation of hydrogen peroxide. <em class='incite-journal-name' onclick='ShowInCiteJournal(169502);'>Free Radic Biol Med</em> 2023;<b>208</b>:153-164. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37543166' target='_blank'>37543166</a> DOI: <a href='https://dx.doi.org/10.1016/j.freeradbiomed.2023.08.004' target='_blank'>10.1016/j.freeradbiomed.2023.08.004</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.freeradbiomed.2023.08.004%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.freeradbiomed.2023.08.004')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.freeradbiomed.2023.08.004','37543166', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.freeradbiomed.2023.08.004' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169502);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/frbm/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/23/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/28/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/01/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/07/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1016/j.freeradbiomed.2023.08.004" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Diabetes is one of the significant risk factors for ischemic stroke. Hyperglycemia exacerbates the pathogenesis of stroke, leading to more extensive cerebral damage and, as a result, to more severe consequences. However, the mechanism whereby the hyperglycemic status in diabetes affects biochemical processes during the development of ischemic injury is still not fully understood. In the present work, we record for the first time the real-time dynamics of H2O2 in the matrix of neuronal mitochondria in vitro in culture and in vivo in the brain tissues of rats during development of ischemic stroke under conditions of hyperglycemia and normal glucose levels. To accomplish this, we used a highly sensitive HyPer7 biosensor and a fiber-optic interface technology. We demonstrated that a high glycemic status does not affect the generation of H2O2 in the tissues of the ischemic core, while significantly exacerbating the consequences of pathogenesis. For the first time using Raman microspectroscopy approach, we have shown how a sharp increase in the blood glucose level increases the relative amount of reduced cytochromes in the mitochondrial electron transport chain in neurons under normal conditions in awake mice. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fiber-optic+interface+technology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fiber-optic interface technology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetically+encoded+fluorescent+biosensor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetically encoded fluorescent biosensor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogen+peroxide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogen peroxide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ischemic+stroke%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ischemic stroke</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Raman+microspectroscopy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Raman microspectroscopy</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ischemic+Stroke%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ischemic Stroke</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogen+Peroxide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogen Peroxide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stroke%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stroke/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperglycemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperglycemia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Ischemia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Ischemia/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Zglejc-Waszak K</b>, Mukherjee K, Korytko A, Lewczuk B, Pomianowski A, Wojtkiewicz J, Banach M, Załęcki M, Nowicka N, Jarosławska J, Kordas B, Wąsowicz K, Juranek JK. Novel insights into the nervous system affected by prolonged hyperglycemia. <em class='incite-journal-name' onclick='ShowInCiteJournal(14576);'>J Mol Med (Berl)</em> 2023;<b>101</b>:1015-1028. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37462767' target='_blank'>37462767</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400689' target='_blank'>PMC10400689</a> DOI: <a href='https://dx.doi.org/10.1007/s00109-023-02347-y' target='_blank'>10.1007/s00109-023-02347-y</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00109-023-02347-y','37462767', 'Hyperglycemia/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(25);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00109-023-02347-y' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14576);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/25/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/15/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/28/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/05/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1007/s00109-023-02347-y" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Multiple molecular pathways including the receptor for advanced glycation end-products-diaphanous related formin 1 (RAGE-Diaph1) signaling are known to play a role in diabetic peripheral neuropathy (DPN). Evidence suggests that neuropathological alterations in type 1 diabetic spinal cord may occur at the same time as or following peripheral nerve abnormalities. We demonstrated that DPN was associated with perturbations of RAGE-Diaph1 signaling pathway in peripheral nerve accompanied by widespread spinal cord molecular changes. More than 500 differentially expressed genes (DEGs) belonging to multiple functional pathways were identified in diabetic spinal cord and of those the most enriched was RAGE-Diaph1 related PI3K-Akt pathway. Only seven of spinal cord DEGs overlapped with DEGs from type 1 diabetic sciatic nerve and only a single gene cathepsin E (CTSE) was common for both type 1 and type 2 diabetic mice. In silico analysis suggests that molecular changes in spinal cord may act synergistically with RAGE-Diaph1 signaling axis in the peripheral nerve. KEY MESSAGES: Molecular perturbations in spinal cord may be involved in the progression of diabetic peripheral neuropathy. Diabetic peripheral neuropathy was associated with perturbations of RAGE-Diaph1 signaling pathway in peripheral nerve accompanied by widespread spinal cord molecular changes. In silico analysis revealed that PI3K-Akt signaling axis related to RAGE-Diaph1 was the most enriched biological pathway in diabetic spinal cord. Cathepsin E may be the target molecular hub for intervention against diabetic peripheral neuropathy. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytoskeleton%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytoskeleton</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuropathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sciatic+nerve%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sciatic nerve</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spinal+cord%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spinal cord</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor+for+Advanced+Glycation+End+Products%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor for Advanced Glycation End Products/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor+for+Advanced+Glycation+End+Products%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor for Advanced Glycation End 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class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img 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class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Hyperglycemia/pathology (996 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Hyperglycemia/pathology (996 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>