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class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="OpeartorItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Contains</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Equals</td> </tr> </table> </div></td> </tr> </table><script id="dxss_597138281" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_24426426" type="text/javascript">  </script><script id="dxss_1793334323" type="text/javascript">  </script> </li> <li id="TermInputContainer" class="fl TermInputContainer"> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue input-text SearchTermText dxeTextBoxDefaultWidthSys" id="SearchTerm"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="SearchTerm_I" name="ctl00$SearchTerm" onfocus="ASPx.EGotFocus('SearchTerm')" onblur="ASPx.ELostFocus('SearchTerm')" onchange="ASPx.EValueChanged('SearchTerm')" value="Kidney/pathology" type="text" /></td> </tr> </table><script id="dxss_543298418" type="text/javascript">  </script> <span class="search-icon-container"> <a class="search-icon" href="javascript:openCategorySelector(1);"><img src="/Contents/Images/search.png" /></a> </span> </li> <li class="fl"> <div class="dxbButton_MetropolisBlue SearchButton dxbButtonSys dxbTSys" id="SearchArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="SearchArticle_I" class="dxb-hb" value="Find an Article" type="submit" name="ctl00$SearchArticle" /><span class="dx-vam">Find an Article</span> </div> </div><script id="dxss_842240986" type="text/javascript">  </script> </li> </ul> <div class="cl"></div> <div class="search-menu"> <span>Find an Article (55823063)</span>   <a href="/Categories" target="_blank">Find a Category (125)</a>   <a href="/SearchJournal" target="_blank">Find a Journal (6158)</a>   <a href="/searchscholar" target="_blank">Find a Scholar (3749)</a>   <a href="/searchacademicassistant" target="_blank">Find an Academic Assistant (18)</a> </div> <div class="search-menu" style="text-align:center;"> <span>Find an Article PDF (4649768)</span>   <a href="/TodayArticles" target="_self">Today's Articles (604)</a>   <span>Subscriber (50864)</span> </div> </div> </div> </div> <script src="/bundles/UserAcademicAchievement?v=QYKvd9c2mOpOgKt90go7osO6NdxcNzivChzWAq_gw3g1"></script> <script type="text/javascript"> $(function () { try { var sort = getQueryString2('sort'); if (sort != null && sort != '') { if ($("[field='st" + sort + "']").length) { $("[field='st" + sort + "']").addClass("sort-highlight"); } if ($("#" + sort + "sortedCheck").length) { $("#" + sort + "sortedCheck").prop("checked", true); } } $("a.readmore").click(function () { $(this).parent().toggle().next().toggle(); }); $("a.readless").click(function () { 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LoadingPanel.Show(); var uri = "/api/BpgUser/DeleteFriend?id=" + id; $.ajax({ type: "get", url: uri, async: false }).done(function () { window.location.href = window.location.href; }); } } function SelectAllFriend() { $("input[name='checkfriend']").each(function () { $(this).attr("checked", $('#selectAllFriend').prop("checked")); }); onCheckFriendClick(); } function onCheckFriendClick() { var itemArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); }); if (itemArray.length > 0) { $("#BatchMessageContainer").show(); } else { $("#BatchMessageContainer").hide(); } } function SendBatchMessages() { var itemArray = new Array(); var idArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); idArray.push($(this).attr("data-id")); }); if (itemArray.length > 0) { if (itemArray.length == 1) { OpenMessage(idArray[0], itemArray[0]); } else { var friendIds = JSON.stringify(itemArray); OpenBatchFriendMessage(friendIds); } } } function ImportSingleArticle(doi, controlId) { if (doi != '') { LoadingPanel.Show(); var uri = "/api/BpgUser/ImportArticle?doiPmid=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function (data) { LoadingPanel.Hide(); if (data) { alert("Import Successfully!"); var currentControl = $("#" + controlId); currentControl.parent().hide(); } }).always(function () { LoadingPanel.Hide(); }); } } function ImportAllArticles() { LoadingPanel.Show(); var term = getQueryString2('term'); var uri = "/api/BpgUser/ImportArticlesFromSearch?term=" + term; $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function () { LoadingPanel.Hide(); alert("Imorting is executing!"); }).always(function () { LoadingPanel.Hide(); }); } </script> <input type="hidden" name="ctl00$RootHolder$RCAId" id="RCAId" /> <input type="hidden" name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">37889</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (1970)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (10362)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Kidney/pathology</label> </div> <div id="yearFacetContainer"> <div class="mnavbar"> <div> Year Published </div> </div> <div class="mnavbox"> <div id="yearFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('year');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refineyearcheck" target="_self">Refine</a> </div> </div> </div> <div id="jsFacetContainer"> <div class="mnavbar"> <div> Article Statistics </div> </div> <div class="mnavbox"> <div id="jsFacetItemContainer"> </div> <div class="refine-btn-container cl" name="refinejscheck"> <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejscheck" target="_self">Refine</a> </div> </div> </div> <div class="mnavbar"> <div> Ranked By </div> </div> <div class="mnavbox"> <ul class="ul sortedby-list"> <li> <input type="radio" id="aisortedCheck" onclick="SetSorted('ai')" name="sortedbycheck" value="aisorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('ai')" id="aisorted">Impact Index Per Article</a> </li> <li> <input type="radio" id="citedf6sortedCheck" onclick="SetSorted('citedf6')" name="sortedbycheck" value="citedf6sorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('citedf6')" id="citedf6sorted"> Citation(s) in <i>RCA</i> </a> </li> </ul> </div> <div id="RootHolder_ResultsAnalysisContainer"> <div class="mnavbar"> <div> Results Analysis </div> </div> <div class="mnavbox"> <ul class="ul analysis-list"> <li> <input type="checkbox" id="YearAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="year" />  <label for="YearAnalysis">Year Published Analysis</label> </li> <li> <input type="checkbox" id="ArticleTypeAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="at" />  <label for="ArticleTypeAnalysis">Article Type Analysis</label> </li> <li> <input type="checkbox" id="JournalTitleAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="journal" />  <label for="JournalTitleAnalysis">Publication Title Analysis</label> </li> <li> <input type="checkbox" id="CategoriesAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="subject" />  <label for="CategoriesAnalysis">Category Analysis</label> </li> </ul> <div class="refine-btn-container cl" name="analysis-check-btn-container"> <a href="javascript:ResultAnalysis();" class="refine-link-btn refine-link-btn-right" target="_self">Results Analysis</a> </div> </div> </div> <div class="refine-btn-container-n cl" id="showFacetsContainer"> <a href="javascript:InitAllFacets();" class="refine-link-btn-right" target="_self">Show more</a> </div> <div id="facetsContainer" class="cl" style="display: none;"> <div class="mnavbar" id="PubDateFacetTitle"> <div> Indexed Articles </div> </div> <div class="mnavbox" id="PubDateFacetContainer"> <ul class="ul 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Integrative multi-omics and network pharmacology reveal the mechanisms of Fangji Huangqi Decoction in treating IgA nephropathy. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118996. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39490710' target='_blank'>39490710</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118996' target='_blank'>10.1016/j.jep.2024.118996</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118996','39490710', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118996' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.jep.2024.118996" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Fangji Huangqi Decoction (FJHQD), a classical Chinese herbal formulation, has demonstrated significant clinical efficacy in the treatment of IgA nephropathy (IgAN), although its mechanisms remain poorly understood. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">This study aims to investigate the renal protective mechanisms of FJHQD using an integrated approach that combines transcriptomics, proteomics, and network pharmacology. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Renal glomerular structure changes were assessed via hematoxylin and eosin (H&E) and Masson staining. IgA expression in the glomeruli was quantified using immunofluorescence. Furthermore, the potential mechanisms underlying the effects of FJHQD were explored through a combined strategy of network pharmacology, transcriptomics, and proteomics. The expression of signaling pathway-related proteins was detected using Western blot. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">FJHQD inhibited mesangial cell proliferation and renal interstitial fibrosis, and significantly reduced excessive IgA deposition in the glomerular mesangium. Network pharmacology identified 113 important active components and 8 common active components in FJHQD, with quercetin, isorhamnetin, jaranol, and kaempferol having the highest number of target interactions. Integration of network pharmacology with multi-omics approaches revealed that 44 active components regulated numerous immune and inflammatory signaling pathways through 17 hub targets. These pathways include the Calcium signaling pathway, cAMP signaling pathway, Ras signaling pathway, MAPK signaling pathway, and PI3K-AKT signaling pathway. Subsequent in vivo experiments demonstrated that FJHQD effectively regulates the identified pathways in IgAN mice. Ultimately, molecular docking results further validated the reliability of the network pharmacology combined with multi-omics analyses. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The findings suggest that FJHQD exerts a renal protective effect, potentially through modulation of the Calcium signaling pathway, cAMP signaling pathway, Ras signaling pathway, MAPK signaling pathway, and PI3K-AKT signaling pathway. These insights offer valuable support for the clinical use of FJHQD and open new avenues for exploring the active compounds and molecular mechanisms of Traditional Chinese Medicines (TCMs). </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fangji+huangqi+decoction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fangji huangqi decoction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IgA+nephropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IgA nephropathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proteomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proteomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcriptomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcriptomics</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; 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padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Cao M</b>, Yang J, Ye H, Cui G, Li W, Zhang X. Leech granules inhibit ferroptosis and alleviate renal injury in mice with diabetic kidney disease. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118995. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39490713' target='_blank'>39490713</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118995' target='_blank'>10.1016/j.jep.2024.118995</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118995','39490713', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118995' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.jep.2024.118995" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">The underlying mechanisms of diabetic kidney disease (DKD) and effective treatment strategies remain unclear. DKD progression is closely associated with abnormal iron metabolism and ferroptosis in vivo. Leeches, used in traditional Chinese medicine for promoting blood circulation and resolving blood stasis, are utilized to treat diabetes and its associated complications. Leeches effectively antagonize oxidative stress injury and exert protective effects on renal function. However, whether leeches can inhibit ferroptosis by modulating oxidative stress and iron metabolism remains unclear. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">To investigate the therapeutic potential of leech granules in DKD and, specifically, their effects on ferroptosis. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">We used a mouse model of DKD. The mice were treated with leech granules via gavage. Component identification and analysis of leech granules were performed using UPLC-MS, and efficacy was assessed by histopathology and analysis of blood glucose, lipids, and renal function. Additionally, the pharmacological mechanisms of leech granules were explored via proteomics, immunohistochemical staining, western blotting, and cell culture. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Proteomic analysis showed that iron metabolism was dysregulated and ferroptosis increased in DKD mice. Leech granules significantly reduced iron accumulation and renal pathological damage, decreased ROS levels, upregulated GSH levels, and inhibited ferroptosis in the kidneys of DKD mice. Furthermore, in vitro cellular experiments demonstrated that leech granules could inhibit erastin-induced ferroptosis and protect renal cells. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">The regulation of renal iron metabolism and inhibition of ferroptosis mediates the therapeutic effect of leech granules on DKD. Leech granules represent a promising approach for DKD treatment. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+kidney+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic kidney disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Iron+metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Iron metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leech+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leech therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proteomic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proteomic</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Nephropathies%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Nephropathies/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leeches%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leeches</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Iron%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Iron/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/complications</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Deora N</b>, Harishankar N, Satyavani M, Sunitha MM, Venkataraman K, Venkateshan V. Deciphering the ameliorative effect of Aloe vera (L.) burm. F. extract on histopathological alterations in Streptozotocin-induced WNIN/GR-ob rats. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118849. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39322021' target='_blank'>39322021</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118849' target='_blank'>10.1016/j.jep.2024.118849</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118849','39322021', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118849' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.jep.2024.118849" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Natural products have emerged as a novel source in the management of non-communicable diseases, more so in diabetes mellitus and its comorbidities. Aloe vera is widely recognized for its anti-hyperglycemic and anti-hyperlipidemic properties and numerous researchers have identified component (s) from Aloe vera attributing to these therapeutic effects. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">The current work was undertaken to gain insight into the protective effect of Aloe vera (L.) Burm. f. extract to study the cytoarchitecture/histopathological alterations in the target organs in mutant Obese WNIN/GR-Ob rats that were made frank diabetic with streptozotocin. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Rats were divided into five groups. 1)WNIN-GR-Ob/control group 2)WNIN-GR-Ob treated with STZ 3)WNIN-GR-Ob + STZ + Sitagliptin 4)WNIN-GR-Ob + STZ + Aloe vera 5)WNIN-GR-Ob/control group + Aloe vera. Histopathological analysis of the pancreas, kidney, liver, and adipocytes was done after 4 weeks of treatment. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The histopathological examination of STZ-induced diabetic rats revealed significant changes in all the vital organs including cell infiltration, degeneration, and necrosis. Treatment with A. vera negated most of the histopathological changes seen in STZ induced rats. Sitagliptin-which served as a positive control in the present study-reversed the alterations seen in streptozotocin rats. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Considering the hypoglycaemic and hypolipidemic activities of Aloe vera that have been previously demonstrated by us, the present study further re-instates the therapeutic efficacy of Aloe vera towards vital organs. It was able to restore islet cells and reduce β-cell damage. In addition, it was also able to aid in kidney tubular regeneration and reverse the degenerative changes brought on by streptozotocin on liver. Further, Aloe vera treated group exhibited moderate hyperplasia with decreased size of adipocytes and reduced macrophage infiltration. Thus, our findings advocate its application as an important nutraceutical in the therapeutic management of diabetes mellitus and associated complications. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aloe+vera%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aloe vera</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pancreatic+%ce%b2-cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pancreatic β-cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Type+2+diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Type 2 diabetes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22WNIN%2fGR-Ob%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">WNIN/GR-Ob</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aloe%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aloe/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypoglycemic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypoglycemic Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypoglycemic+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypoglycemic Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Streptozocin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Streptozocin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pancreas%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pancreas/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pancreas%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pancreas/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipocytes%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipocytes/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Mao Y</b>, Xu H, Xia P. Ilex cornuta leaves extracts ameliorate hyperuricemia by modulating uric acid transporters. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>336</b>:118618. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39069031' target='_blank'>39069031</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118618' target='_blank'>10.1016/j.jep.2024.118618</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118618','39069031', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118618' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.jep.2024.118618" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Ilex cornuta is a valuable species of the Holly genus (Aquifoliaceae), and mainly distributed in eastern China. It is not only made into tea, namely Kudingcha, but also used as traditional medicine to relieve cough, headache, gout, and nourish liver and kidney. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">The purpose of this study was to explore the exact efficacy of different extracts from Ilex cornuta in the treatment of hyperuricemia in vitro and in vivo, and to explore its pharmacological mechanism, so as to bring new ideas for the development of new drugs for reducing uric acid (UA) and anti-gout. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Five crude extracts from Ilex cornuta leaves were extracted by different methods. Then, the xanthine oxidase inhibitory activity and antioxidant capacity of 5 extracts in vitro were compared to screen the extract with the most UA regulating potential. In vivo experiment, hyperuricemia model of mice was established by intragastric administration of potassium oxonate and feeding high yeast diet. Biochemical indexes such as serum UA level, xanthine oxidase activity, liver and kidney index of mice in each group were detected. The pathological sections of kidney and liver tissues were also observed and compared. The mechanism of Ilex cornuta leaves (western blotting, and RT-qPCR) in the treatment of hyperuricemia was further explored by targeting UA transporters ABCG2, GLUT9, and URAT1. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The in vitro results of inhibitory activity of xanthine oxidase showed that the crude saponin extract was the best, followed by crude flavonoids extract. Then, the in vivo results reflected that both crude saponins and crude flavonoids extracts could significantly reduce the serum UA level, inhibit the activity of xanthine oxidase in serum and liver, and maintain serum urea nitrogen and creatinine at normal level. Meanwhile, there was no liver and kidney injury in mice. Through the comparison of the mechanism results, it was found that both extracts could up-regulate the expression of ABCG2 protein and mRNA related to UA excretion, and down-regulate the expression of GLUT9 and URAT1 protein and mRNA. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The crude flavonoids and saponins of Ilex cornuta leaves not only inhibited XOD activity in vitro, but also significantly controlled XOD activity and reduced UA level in hyperuricemia mice in vivo. One of the potential mechanisms was to regulate UA level in vivo by regulating ABCG2, GLUT9, and URAT1 transporters directly related to UA transport, thus achieving the effect of intervening hyperuricemia. This study provided a preliminary experimental basis for the development of new drugs of Ilex cornuta leaves for treating hyperuricemia. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperuricemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperuricemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ilex+cornuta%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ilex cornuta</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uric+acid+transporter%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uric acid transporter</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xanthine+oxidase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xanthine oxidase</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a 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<td> <div id="citation5" class="article-citation"> <b>Bangar NS</b>, Dixit A, Apte MM, Tupe RS. Syzygium cumini (L.) skeels mitigate diabetic nephropathy by regulating Nrf2 pathway and mitocyhondrial dysfunction: In vitro and in vivo studies. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>336</b>:118684. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39127117' target='_blank'>39127117</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118684' target='_blank'>10.1016/j.jep.2024.118684</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118684','39127117', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118684' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/12/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.jep.2024.118684" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL PREVALENCE</div><div class="abstract-content">Hyperglycemia in diabetes increases the generation of advanced glycation end products (AGEs) through non-enzymatic reactions. The interaction between AGEs and their receptors (RAGE) leads to oxidative and inflammatory stress, which plays a pivotal role in developing diabetic nephropathy. Syzygium cumini (SC) L. (DC.) homeopathic preparations viz. 200C, 30C, and mother tincture [MT] are used to treat diabetes. This study aimed to elucidate the regulatory effects of SC preparations (200C, 30C, and MT) on the nuclear factor erythroid 2-related factor 2 (Nrf2) - nuclear factor-κB (NF-κB) pathways and mitochondrial dysfunction in mitigating diabetic nephropathy (DN). </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Streptozotocin-induced diabetic rats were treated with SC preparations (200C, 30C, MT; 1:20 dilution in distilled water; 600 μL/kg body weight) and metformin (45 mg/kg body weight) twice daily for 40 days. DN was evaluated through biochemical parameters and histological examination. Renal tissue lysates were analyzed for glycation markers. Protein and gene levels of Nrf2, NF-κB, and mitochondrial dysfunctional signaling were determined via western blotting and RT-qPCR. An immunohistochemical analysis of the kidneys was performed. In vitro, human serum albumin (HSA - 10 mg/ml) was glycated with methylglyoxal (MGO - 55 mM) in the presence of SC preparations (200C, 30C, MT) for eight days. Glycated samples (400 μg/mL) were incubated with renal cells (HEK-293) for 24 h. Further reactive oxygen species production, Nrf2 nuclear translocation, and protein or gene expression of Nrf2 and apoptosis markers were analyzed by western blotting, RT-qPCR, and flow cytometry. Molecular docking of gallic and ellagic acid with the HSA-MGO complex was performed. </div><div class="abstract-label">RESULT</div><div class="abstract-content">In vivo experiments using streptozotocin-induced diabetic rats treated with SC preparations exhibited improved biochemical parameters, preserved kidney function, and reduced glycation adduct formation in a dose-dependent manner. Furthermore, SC preparations downregulated inflammatory mediators such as RAGE, NF-κB, vascular endothelial growth factor (VEGF), and Tumor necrosis factor α (TNF-α) while upregulating the Nrf2-dependent antioxidant and detoxification pathways. They downregulated B-cell lymphoma 2 (Bcl-2) associated X-protein (BAX), C/EBP homologous protein (CHOP), Dynamin-related protein 1 (DRP1), and upregulated BCL 2 gene expression. Notably, SC preparations facilitated nuclear translocation of Nrf2, leading to the upregulation of antioxidant enzymes and the downregulation of oxidative stress markers. Molecular docking studies revealed favorable interactions between gallic (-5.26 kcal/mol) and ellagic acid (-4.71 kcal/mol) with the HSA-MGO complex. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">SC preparations mitigate renal cell apoptosis and mitochondrial dysfunction through Nrf2-dependent mechanisms. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+nephropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic nephropathy</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antioxidants%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antioxidants/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Delrue C</b>, Steenbeke M, Vrielinck H, Derave W, Everaert I, Delanghe JR, Baelde H, De Bruyne S, Speeckaert MM. Near-infrared microscopy reveals diabetic nephropathy in ob/ob mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(21752);'>Talanta</em> 2025;<b>282</b>:126930. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39357406' target='_blank'>39357406</a> DOI: <a href='https://dx.doi.org/10.1016/j.talanta.2024.126930' target='_blank'>10.1016/j.talanta.2024.126930</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.talanta.2024.126930','39357406', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.talanta.2024.126930' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(21752);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.talanta.2024.126930" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Diabetic nephropathy (DN) is a major cause of global kidney failure. While histological kidney biopsy is the gold standard for diagnosis, it primarily reveals tissue morphology. In contrast, near-infrared (NIR) microscopy offers a label-free method for detailed molecular characterization of kidney tissue. Hematoxylin and eosin-stained kidney tissue samples from 17 ob/ob mice with DN and 14 healthy mice were examined using Fourier transform-NIR microscopy. Four different spectra were obtained from both the mesangium and tubulus. NIR spectral analysis unveiled distinct differences in wavenumbers between DN-affected and healthy kidneys, notably in the carbohydrate and protein-associated region (5500-4200 cm-1). In the mesangium, DN tissue samples exhibited higher median values at 4235 cm-1, 4659 cm-1, 4844 cm-1, 4906 cm-1, and 5222 cm-1 compared to controls (P < 0.05, P < 0.01, P < 0.05, P < 0.05 and P < 0.001, respectively). In tubular spectra, higher median values were found at 4258 cm-1, 4659 cm-1, 5222 cm-1, and 5346 cm-1 in the DN group (P < 0.01, P < 0.05, P < 0.05 and P < 0.01, respectively). These spectral differences strongly correlated with metabolic, histologic, and urinary parameters, providing valuable DN progression insights. The classification model achieved a visible clustering between the control and DN group for both the mesangial and tubular measurements. NIR microscopy demonstrated significant spectral differences between DN and healthy kidney tissues in mice, hinting at its potential for providing chemical insights, aiding in more accurate diagnoses, and offering a foundation for further clinical exploration and potential therapeutic advancements in DN. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biochemical+signatures%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biochemical signatures</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+nephropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic nephropathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+tissue+sections%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney tissue sections</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microscopy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microscopy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Near-infrared+spectroscopy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Near-infrared spectroscopy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ob%2fob+mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ob/ob mice</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Nephropathies%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Nephropathies/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microscopy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microscopy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Obese%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Obese</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spectroscopy%2c+Near-Infrared%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spectroscopy, Near-Infrared/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Zangisheh M</b>, Masoudifard M, Madani SA, Vajhi A, Hasannejhad H, Ghojoghi A. Radiographic and tomographic findings of excretory urography of avian kidneys after induced nephropathy in broiler chicken as a model. <em class='incite-journal-name' onclick='ShowInCiteJournal(23384);'>Vet Med Sci</em> 2025;<b>11</b>:e70036. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39560332' target='_blank'>39560332</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574877' target='_blank'>PMC11574877</a> DOI: <a href='https://dx.doi.org/10.1002/vms3.70036' target='_blank'>10.1002/vms3.70036</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/vms3.70036','39560332', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/vms3.70036' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(23384);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/30/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/20/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1002/vms3.70036" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Although kidney diseases have a high prevalence, initial recognition and diagnosis of renal disease are complicated in avian medicine. </div><div class="abstract-label">OBJECTIVE</div><div class="abstract-content">The aim of this study is to assess the intraosseous excretory urography (IOEU) in order to introduce a new method for evaluation of kidney's function in broilers as a primary model of birds. </div><div class="abstract-label">METHODS</div><div class="abstract-content">A total of 10 male broiler chickens at the age of 20 days were included and evaluated with plain and serial post-contrast radiography and computed tomography (CT) scan to check the time and concentration of the contrast media (CM) passage from the kidney. In the next step, after the nephropathy induction with gentamicin, plain and serial post-contrast radiography and CT scan were repeated. After the necropsy, kidney samples were sent for histopathology evaluation, and statistical analysis of data obtained from image analysis was conducted. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">After nephropathy induction, all of the chickens exhibited increase in kidney size and in histopathological evaluation, all the samples (30 of 30) showed severe tubular necrosis and mild glomerulopathy. In the IOEU, the average time to create the maximum concentration of CM, the average time to decrease the CM concentration from the kidney and the time of the complete clearance of CM indicated a significant incensement after nephropathy compared to the time before it. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Intraosseous excretory urography (IOEU) is a safe contrast imaging modality and can be useful in the assessment of the urinary system in chickens to check the changes in kidney size and function. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CT+scan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CT scan</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22avian+kidneys%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">avian kidneys</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22broiler+chicken%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">broiler chicken</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22excretory+urography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">excretory urography</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nephropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nephropathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22radiography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">radiography</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chickens%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chickens</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Poultry+Diseases%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Poultry Diseases/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Poultry+Diseases%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Poultry Diseases/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Poultry+Diseases%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Poultry Diseases/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Urography%2fveterinary%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Urography/veterinary</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Urography%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Urography/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Diseases%2fveterinary%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Diseases/veterinary</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Diseases%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Diseases/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Diseases%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Diseases/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Diseases%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Diseases/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Diseases%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Diseases/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tomography%2c+X-Ray+Computed%2fveterinary%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tomography, X-Ray Computed/veterinary</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Contrast+Media%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Contrast Media</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gentamicins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gentamicins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Xu M</b>, Xiao H, Zou X, Pan L, Song Q, Hou L, Zeng Y, Han Y, Zhou Z. Mechanisms of levan in ameliorating hyperuricemia: Insight into levan on serum metabolites, gut microbiota, and function in hyperuricemia rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(4492);'>Carbohydr Polym</em> 2025;<b>347</b>:122665. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39486924' target='_blank'>39486924</a> DOI: <a href='https://dx.doi.org/10.1016/j.carbpol.2024.122665' target='_blank'>10.1016/j.carbpol.2024.122665</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.carbpol.2024.122665','39486924', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.carbpol.2024.122665' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4492);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.carbpol.2024.122665" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study aims to investigate the effects of levan on the progression of hyperuricemia (HUA) rats and elucidate its underlying mechanisms. After levan intervention, both low and high-dose groups exhibited a significant decrease in serum uric acid (UA) levels, reaching 71.0 % and 77.5 %, respectively, compared to the model group. Furthermore, levan could alleviate renal pathological damage caused by glomerular cell vacuolation, inflammatory infiltration and collagen deposition. The results of enzyme activity assay and real-time fluorescence quantitative PCR showed that levan decreased UA production by inhibiting adenosine deaminase (ADA) activity and gene expression in liver; it upregulated ATP-binding cassette subfamily G member 2 protein (ABCG2) and organic anion transporter 1 (OAT1) transporter gene expression in the kidney, promoting UA excretion. Gut microbiome analysis indicated that levan regulated gut flora dysbiosis induced by HUA, resulting in up-regulated the abundance of beneficial bacteria (Muribaculaceae, Faecalibaculum, Bifidobacterium, and Lactobacillus) and decreased conditioned pathogenic bacteria (Escherichia_Shigella and Proteus). Non-targeted metabolomics showed changes in various serum metabolites associated with glycerophospholipid metabolism, lipid metabolism, and inflammation following oral administration of levan. Therefore, levan may be a promising functional dietary supplement for regulating the gut flora and remodeling of metabolic disorders in individuals with HUA. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exopolysaccharides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exopolysaccharides</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gut+microbiota%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gut microbiota</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperuricemia+rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperuricemia rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Levan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Levan</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Serum+metabolomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Serum metabolomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Serum+uric+acid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Serum uric acid</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fructans%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fructans/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperuricemia%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperuricemia/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uric+Acid%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uric Acid/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Liu Y</b>, Wu Q, Huang Z, Zhou D, Cai C, Luo W, Feng P. TLR4 Inhibitor TAK-242 Protected Henoch-Schonlein Purpura Nephritis in Rats by Regulating Inflammatory Response and Immune Competence via NF- κB/NLRP3 Signalling. <em class='incite-journal-name' onclick='ShowInCiteJournal(169839);'>Clin Exp Pharmacol Physiol</em> 2025;<b>52</b>:e70008. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39564921' target='_blank'>39564921</a> DOI: <a href='https://dx.doi.org/10.1111/1440-1681.70008' target='_blank'>10.1111/1440-1681.70008</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/1440-1681.70008','39564921', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(9);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/1440-1681.70008' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169839);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1111/1440-1681.70008" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study aimed to explore the effect of toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB)/NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) signalling on Henoch-Schonlein purpura nephritis (HSPN). We established a HSPN rat model in a high-altitude hypoxic (HH) environment. Renal tissue lesions were observed by haematoxylin and Eosin (H&E) staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL), CD20-postive B cells and CD68-postive macrophage cells were detected by immunohistochemistry, T-cell activation was detected by flow cytometry and toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB)/NOD-like receptor thermal protein domain associated protein 3 (NLRP3) signalling was detected by western blot. TAK-242 inhibited the expression of TLR4/NF-κB/NLRP3 signalling related-proteins, decreased the levels of 24 h urinary protein, serum creatinine, circular immune complex (CIC) and kidney immunoglobulin A (IgA), and improved renal histopathological damage in HH-HSPN rats. Furthermore, TAK-242 attenuated the infiltration of CD20 and CD68 into the kidney and increased the percentage of CD3+, CD4+ and CD4+/CD8+ cells in the blood of HH-HSPN rats. The study revealed that suppressing TLR4/NF-κB/NLRP3 signalling improved renal function and histopathological damage, and this improvement was related to inhibiting the inflammatory response and enhancing immune competence. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Henoch%e2%80%93Schonlein+purpura+nephritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Henoch–Schonlein purpura nephritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TLR4+inhibitor+TAK%e2%80%90242%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TLR4 inhibitor TAK‐242</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TLR4%2fNF%e2%80%90%ce%baB%2fNLRP3+signalling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TLR4/NF‐κB/NLRP3 signalling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22high%e2%80%90altitude+hypoxia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">high‐altitude hypoxia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunoglobulin+A+nephropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunoglobulin A nephropathy</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IgA+Vasculitis%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IgA Vasculitis/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IgA+Vasculitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IgA Vasculitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLR+Family%2c+Pyrin+Domain-Containing+3+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLR Family, Pyrin Domain-Containing 3 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLR+Family%2c+Pyrin+Domain-Containing+3+Protein%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptor+4%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptor 4/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptor+4%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptor 4/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nephritis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nephritis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nephritis%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nephritis/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nephritis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nephritis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nephritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nephritis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sulfonamides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sulfonamides</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qinghai+Provincial+Health+Commission+Fund+Project+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2020-wjzdx-125 Qinghai Provincial Health Commission Fund Project of China</a></li></ul> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Lin KYK</b>, Chan EYH, Mak YF, To MC, Wong SW, Lai FFY, Ho TW, Tong PC, Lai WM, Yap DYH, Ma ALT. Renal vascular lesions in childhood-onset lupus nephritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(18886);'>Pediatr Nephrol</em> 2025;<b>40</b>:131-141. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39249126' target='_blank'>39249126</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584461' target='_blank'>PMC11584461</a> DOI: <a href='https://dx.doi.org/10.1007/s00467-024-06498-z' target='_blank'>10.1007/s00467-024-06498-z</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00467-024-06498-z','39249126', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00467-024-06498-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18886);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/pnep' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1007/s00467-024-06498-z" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">This study aimed to determine the clinical significance of renal vascular lesions (RVLs) in childhood-onset lupus nephritis (cLN). </div><div class="abstract-label">METHODS</div><div class="abstract-content">We retrospectively reviewed all children with biopsy-proven cLN between 2004-2020 to evaluate the prevalence of RVLs on kidney biopsy and its associated factors and long-term outcomes. The composite kidney outcome was defined as advanced chronic kidney disease (CKD) stage 3-5, kidney failure and death. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">107 biopsies from 84 Chinese patients were analysed. RVLs were observed in 19 patients (22.6%), including non-inflammatory necrotizing vasculopathy (NNV, n = 6), thrombotic microangiopathy (TMA, n = 4), arterial sclerosis (AS, n = 3), concurrent NNV with AS (n = 4), concurrent NNV with TMA (n = 1) and concurrent true renal vasculitis with AS (n = 1). The presence of RVLs was associated with lower estimated glomerular filtration rate (eGFR) (66.9 ± 40.3 vs. 95.6 ± 39.4 ml/min/1.73m2, p = 0.005), haemoglobin level (9.1 ± 1.9 vs. 10.4 ± 1.9 g/dL, p = 0.008) and platelet count (150.1 ± 96.4 vs. 217.2 ± 104.8 × 109/L, p = 0.01). LN classes and activity/chronicity indices were similar. Patients with RVLs had poorer composite kidney outcomes, though not reaching statistical significance (log-rank test, p = 0.06). The presence of NNV was associated with inferior survival free from composite kidney outcome (log-rank test, p = 0.0018), compared to other forms of RVLs and those without RVLs. Univariate analysis revealed NNV (HR 7.08, 95% CI 1.67-30.03) was predictive of composite kidney outcome. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">RVLs are present in one-fifth of cLN patients and are associated with severe presentation. NNV is associated with worse long-term kidney outcome. Routine evaluation of RVLs is warranted and should be incorporated into future classification criteria. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Childhood-onset+lupus+nephritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Childhood-onset lupus nephritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-inflammatory+necrotizing+vasculopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-inflammatory necrotizing vasculopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Renal+vascular+lesions%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Renal vascular lesions</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SLE%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SLE</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Systemic+lupus+erythematosus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Systemic lupus erythematosus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thrombotic+microangiopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thrombotic microangiopathy</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lupus+Nephritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lupus Nephritis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lupus+Nephritis%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lupus Nephritis/complications</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22China%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">China/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Renal+Insufficiency%2c+Chronic%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Renal Insufficiency, Chronic/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Renal+Insufficiency%2c+Chronic%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Renal Insufficiency, Chronic/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vascular+Diseases%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vascular Diseases/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vascular+Diseases%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vascular Diseases/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vascular+Diseases%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vascular Diseases/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vascular+Diseases%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vascular Diseases/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Age+of+Onset%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Age of Onset</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Che R</b>, Miao M, Ding G, Zhao S. A rare case of late-onset immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome confused with IgA vasculitis nephropathy. <em class='incite-journal-name' onclick='ShowInCiteJournal(18886);'>Pediatr Nephrol</em> 2025;<b>40</b>:89-93. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39190146' target='_blank'>39190146</a> DOI: <a href='https://dx.doi.org/10.1007/s00467-024-06482-7' target='_blank'>10.1007/s00467-024-06482-7</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s00467-024-06482-7','39190146', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(11);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s00467-024-06482-7' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18886);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/pnep' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1007/s00467-024-06482-7" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">A 3-year-old boy initially presented with purpura-like rashes and nephrotic syndrome, suspected to be IgA vasculitis nephritis (IgAVN). The suggestion of kidney biopsy was rejected. Although the patient responded well to glucocorticoids, they later developed recurrent proteinuria, refractory diarrhea, and subsequent metabolic acidosis. Kidney biopsy showed membranous nephropathy with positive semaphorin 3B expression, indicative of other kidney diseases rather than IgAVN. Although his kidney responded well to glucocorticoid combined with cyclosporine A treatment regimen, enteropathy and severe food allergy still progressed afterwards as evidenced by villous atrophy on gastrointestinal endoscopy examination. Whole exome sequencing identified a heterozygous missense variant in exon 11 of FOXP3: c.1121 T > G, confirming the diagnosis of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The case expanded the phenotypic spectrum of IPEX syndrome, suggesting high phenotypic heterogeneity despite similar genotypes. It also put emphasis on the significance of kidney biopsy to differentiate IgA vasculitis nephropathy from other immune disorders. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FOXP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FOXP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IPEX%c2%a0syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IPEX syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IgA+vasculitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IgA vasculitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membranous+nephropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membranous nephropathy</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a 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target="_blank">Diarrhea</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82200744 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Health+Science+and+Technology+Development+Special+Foundation+of+Nanjing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">YKK22159 Health Science and Technology Development Special Foundation of Nanjing</a></li></ul> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Zhao X</b>, Ma C, Li L, Yang Y, Zhang S, Wang X. Human Adipose Tissue-Derived Stromal Cells Ameliorate Adriamycin-Induced Nephropathy by Promoting Angiogenesis. <em class='incite-journal-name' onclick='ShowInCiteJournal(18488);'>Organogenesis</em> 2024;<b>20</b>:2356339. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38796830' target='_blank'>38796830</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135856' target='_blank'>PMC11135856</a> DOI: <a href='https://dx.doi.org/10.1080/15476278.2024.2356339' target='_blank'>10.1080/15476278.2024.2356339</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15476278.2024.2356339','38796830', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15476278.2024.2356339' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18488);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/14/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/29/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1080/15476278.2024.2356339" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study is to investigate the therapeutical effect and mechanisms of human-derived adipose mesenchymal stem cells (ADSC) in relieving adriamycin (ADR)-induced nephropathy (AN). SD rats were separated into normal group, ADR group, ADR+Losartan group (20 mg/kg), and ADR + ADSC group. AN rats were induced by intravenous injection with adriamycin (8 mg/kg), and 4 d later, ADSC (2 × 105 cells/mouse) were administrated twice with 2 weeks interval time (i.v.). The rats were euthanized after the 6 weeks' treatment. Biochemical indicators reflecting renal injury, such as blood urea nitrogen (BUN), neutrophil gelatinase alpha (NGAL), serum creatinine (Scr), inflammation, oxidative stress, and pro-fibrosis molecules, were evaluated. Results demonstrated that we obtained high qualified ADSCs for treatment determined by flow cytometry, and ADSCs treatment significantly ameliorated renal injuries in DN rats by decreasing BUN, Scr and NGAL in peripheral blood, as well as renal histopathological injuries, especially protecting the integrity of podocytes by immunofluorescence. Furthermore, ADSCs treatment also remarkably reduced the renal inflammation, oxidative stress, and fibrosis in DN rats. Preliminary mechanism study suggested that the ADSCs treatment significantly increased renal neovascularization via enhancing proangiogenic VEGF production. Pharmacodynamics study using in vivo imaging confirmed that ADSCs via intravenous injection could accumulate into the kidneys and be alive at least 2 weeks. In a conclusion, ADSC can significantly alleviate ADR-induced nephropathy, and mainly through reducing oxidative stress, inflammation and fibrosis, as well as enhancing VEGF production. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ADSC%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ADSC</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adriamycin+nephropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adriamycin nephropathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22angiogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">angiogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22renal+fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">renal fibrosis</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Doxorubicin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Doxorubicin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Diseases%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Diseases/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Diseases%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Diseases/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neovascularization%2c+Physiologic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neovascularization, Physiologic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cell+Transplantation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cell Transplantation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vascular+Endothelial+Growth+Factor+A%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vascular Endothelial Growth Factor A/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stromal+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stromal Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Angiogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Angiogenesis</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Han H</b>, Gao Y, Chen B, Xu H, Shi C, Wang X, Liang Y, Wu Z, Wang Z, Bai Y, Wu C. Nrf2 inhibits M1 macrophage polarization to ameliorate renal ischemia-reperfusion injury through antagonizing NF-κB signaling. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>143</b>:113310. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39383788' target='_blank'>39383788</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113310' target='_blank'>10.1016/j.intimp.2024.113310</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113310','39383788', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.113310' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.intimp.2024.113310" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Renal ischemia-reperfusion injury (IRI) is a condition that arises from a sudden interruption of the blood flow to the kidney for a period of time followed by restoration of the blood supply. This process contributes to acute kidney injury (AKI), increases morbidity and mortality, and is a major risk factor for chronic kidney disease (CKD). Nuclear factor erythroid-derived 2-like 2 (Nrf2) has been shown to exhibit strong anti-oxidative and anti-inflammatory effects, which are reciprocally regulated by the pro-inflammatory actions of nuclear factor-kappa B (NF-κB) signaling. In this study, we established a model of AKI caused by renal IRI in mice lacking the Nrf2 gene (KO-Nrf2) and mice pre-injected with ML385 (Nrf2 inhibitor). In addition, LPS- or IL-4-induced M1- or M2-type polarized macrophages (RAW264.7), respectively, were also treated with Nrf2 activation and inhibition. The results demonstrated a more pronounced activation of the NF-κB signaling pathway in the Nrf2 inhibition model, accompanied by a more severe inflammatory effect. In cultured macrophages and renal IRI mice, Nrf2 inhibition activated M1 macrophage polarization, thereby increasing the release of proinflammatory cell factors (iNOS and TNF-α) and aggravating renal IRI. Notably, the inhibitory effect of Nrf2 on M1 macrophage polarization was related to the downregulation of the NF-κB signaling pathway activity, resulting in partial relief of renal IRI. Consequently, our findings indicated that Nrf2 inhibits M1 macrophage polarization to ameliorate renal IRI through antagonizing NF-κB signaling. Targeted activation of Nrf2 may be one of the important strategies for renal IRI treatment. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ischemia-reperfusion+injury+(IRI)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ischemia-reperfusion injury (IRI)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-%ce%baB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-κB</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nrf2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nrf2</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-E2-Related+Factor+2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-E2-Related Factor 2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-E2-Related+Factor+2%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-E2-Related Factor 2/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reperfusion+Injury%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reperfusion Injury/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reperfusion+Injury%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reperfusion Injury/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+Kidney+Injury%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute Kidney Injury/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+Activation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage Activation</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Yao R</b>, Pan JS, He RB, Hou BB, Suo XG, Li GX, Xia KG, Hu DK, Mao XK, Li W, Hao ZY. Pectolinarigenin alleviates calcium oxalate-induced renal inflammation and oxidative stress by binding to HIF-1α. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>143</b>:113284. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39378657' target='_blank'>39378657</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113284' target='_blank'>10.1016/j.intimp.2024.113284</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113284','39378657', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.113284' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.intimp.2024.113284" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Calcium oxalate (CaOx) crystals are the main constituents of renal crystals in humans and induce tubular lumen damage in renal tubules, leading to renal calcium deposition and kidney stone formation. Oxidative stress and inflammation play important roles in regulating calcium oxalate-induced injury. Here, we evaluated the efficacy in inhibiting oxidation and inflammation of pectinolinarigenin, a biologically active natural metabolite, in CaOx nephrocalcinosis and further explored its targets of action. First, we developed cellular and mouse models of calcium oxalate renal nephrocalcinosis and identified the onset of oxidative stress and inflammation according to experimental data. We found that pectolinarigenin inhibited this onset while reducing renal crystal deposition. Network pharmacology was subsequently utilized to screen for hypoxia-inducible factor-1α (HIF-1α), a regulator involved in the body's release and over-oxidation of inflammatory factors. Finally, molecular docking, cellular thermal shift assay, and other experiments to detect HIF-1α expression showed that pectolinarigenin directly combined with HIF-1α and prevented downstream reactive oxygen species activation and release. Our results indicate that pectolinarigenin can target and inhibit HIF-1α-mediated inflammatory responses and oxidative stress damage and be a novel drug for CaOx nephrocalcinosis treatment. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcium+oxalate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcium oxalate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HIF-1%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HIF-1α</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nephrocalcinosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nephrocalcinosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pectolinarigenin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pectolinarigenin</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypoxia-Inducible+Factor+1%2c+alpha+Subunit%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypoxia-Inducible Factor 1, alpha Subunit/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcium+Oxalate%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcium Oxalate/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Docking+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Docking Simulation</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chromones%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chromones</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Yao X</b>, Yang S, Chen L, Lin F, Ruan Y, Rao T, Cheng F. The bach1/G9a/Slc7a11 axis epigenetically promotes renal fibrosis by mediated ferroptosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>143</b>:113363. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39393269' target='_blank'>39393269</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113363' target='_blank'>10.1016/j.intimp.2024.113363</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113363','39393269', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.113363' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/13/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1016/j.intimp.2024.113363" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">A high percentage of individuals with renal fibrosis are susceptible to developing chronic kidney disease (CKD), and conventional therapy fails to halt the progression of renal fibrosis and CKD. Here, we assessed the potential functions of G9a in a unilateral ureteral obstruction (UUO)-induced renal fibrosis mouse model. The expression of G9a was significantly increased in the fibrotic kidneys of patients and mice. G9a knockout inhibited inflammatory cytokine production and collagen deposition in mice, whereas its overexpression aggravated renal fibrosis in mice. In vitro, the knockdown of G9a alleviated the production of inflammatory cytokines and renal fibrosis. G9a, a histone methyltransferase, interacts with transcription factor Bach1 and activates ferroptosis by suppressing the transcription of Slc7a11 via dimethylation of histone 3 lysine 9 (H3K9me2) both in vivo and in vitro. Collectively, our findings indicate that G9a could be an attractive therapeutic target for renal fibrosis. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22G9a%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">G9a</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histone+modification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histone 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Insufficiency, Chronic/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Renal+Insufficiency%2c+Chronic%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Renal Insufficiency, Chronic/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Renal+Insufficiency%2c+Chronic%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Renal Insufficiency, Chronic/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Jin D</b>, Tu X, Xu W, Zheng H, Zeng J, Bi P, Yang R, Li Y, Ni J, Zhu C, Chen H, Yu D, Wan F. Identification and validation of diagnostic markers related to immunogenic cell death and infiltration of immune cells in diabetic nephropathy. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>143</b>:113236. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39378654' target='_blank'>39378654</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113236' target='_blank'>10.1016/j.intimp.2024.113236</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113236','39378654', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.113236' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1016/j.intimp.2024.113236" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">INTRODUCTION</div><div class="abstract-content">Immunogenic cell death (ICD) is a unique cell death triggered by chemotherapy. However, studies elucidating the potential therapeutic role of ICD and the underlying mechanism in diabetic nephropathy (DN) are limited. </div><div class="abstract-label">METHODS</div><div class="abstract-content">WGCNA was conducted on the human kidney biopsy data linked to DN, analyzing gene sets associated with ICD. Gene Set Enrichment Analysis and Gene Set Variation Analysis were utilized to examine the discrepancy in biological function. We used Gene Ontology, the Kyoto Encyclopedia of Genes and Genomes, and the GeneMANIA database to investigate the function of the signature genes. An analysis using the receiver operating characteristic (ROC) was conducted to validate the diagnostic value of hub genes. Additionally, immune infiltration-related analyses were also performed. In conclusion, we examined the association between the glomerular filtration rate, serum creatinine, and hub genes. Hub genes were validated by immunohistochemistry using db/db mice kidneys. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">WGCNA revealed that the targets in the turquoise unit (1674 genes) exhibited the highest positive correlation with ICD. Furthermore, 4222 statistically significant DEGs were identified when comparing the DN and healthy control groups. Significantly, the KEGG pathway enrichment analysis indicated a connection between ICD and the nuclear factor-kappa B signaling pathway and the synthesis of cytokines (tumor necrosis factor superfamily). ROC analysis revealed that 16 hub genes exhibited strong discriminatory potential as biomarkers for DN. Therefore, immunohistochemical validation, with the potential involvement of chemokines (CCL11, CCR2, CCR7, CX3CR1, CXCL10, CXCL12, and CXCR5) and immune cells (CD3G, CD5, and CD247) may be crucial for the diagnosis and therapy of DN. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">DKK3, NR4A1, NR4A2, VEGFA, and DUSP1 may be associated with the development of DN. The pathogenesis of DN may specifically involve chemokines (CCL11, CCR2, CCR7, CX3CR1, CXCL10, CXCL12, and CXCR5) and immune cells (CD3G, CD5, and CD247), with LCP2 playing a significant role. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+nephropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic nephropathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Differential+gene+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Differential gene analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Experimental+verification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Experimental verification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunogenic+cell+death%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunogenic cell death</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PPI+network+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PPI network analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Renal+biopsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Renal biopsy</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Nephropathies%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Nephropathies/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Nephropathies%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Nephropathies/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Nephropathies%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Nephropathies/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+Nephropathies%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic Nephropathies/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunogenic+Cell+Death%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunogenic Cell Death</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Profiling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Profiling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Regulatory+Networks%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Regulatory Networks</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Huang W</b>, Zhang H, Wang L, Zhang F, Ma M, Chen D, Wan X, Zhang Y, Cao C. Ulinastatin attenuates renal ischemia-reperfusion injury by inhibiting NLRP3 inflammasome-triggered pyroptosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>143</b>:113306. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39405939' target='_blank'>39405939</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113306' target='_blank'>10.1016/j.intimp.2024.113306</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113306','39405939', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.113306' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1016/j.intimp.2024.113306" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Systemic inflammation is involved in developing acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB). Ulinastatin, a urinary trypsin inhibitor (UTI), has various anti-inflammatory effects. Our previous data displayed that UTI administration during CPB played a protective role in reducing the risk of AKI after cardiac surgery; however, its role in AKI pathogenesis remains unknown. In this study, UTI effectively decreased the expression levels of inflammatory factors, including tumor necrosis factor (TNF)-α, interleukin (IL)-6, and interleukin (IL)-18, in patients with CPB. Moreover, the proportion of patients with postoperative AKI decreased significantly. Experimental AKI was induced by 35 min of ischemia, followed by 48 h of reperfusion.The results showed that the preoperative administration of UTI reduced inflammatory cell infiltration and decreased the levels of pro-inflammatory cytokines, including IL-6, IL-18, and TNFα. Meanwhile, UTI inhibited apoptosis, reduced mitochondrial reactive oxygen species production. We further revealed that UTI could inhibit NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation by increasing the expression of nuclear factor-κB (IκB) kinase-alpha (IKKα) interacting with apoptosis-associated speck-like protein containing CARD (ASC) to alleviate kidney damage. These findings provide evidence of the renoprotective role of UTI in cardiac surgery-associated (CSA)-AKI, which is associated with the inhibition of NLRP3 inflammasome activation by upregulating IKKα. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardiac+surgery-associated+acute+kidney+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardiac surgery-associated acute kidney injury</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IKK%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IKKα</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3+inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3 inflammasome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ulinastatin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ulinastatin</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLR+Family%2c+Pyrin+Domain-Containing+3+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLR Family, Pyrin Domain-Containing 3 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycoproteins%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycoproteins/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycoproteins%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycoproteins/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reperfusion+Injury%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reperfusion Injury/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reperfusion+Injury%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reperfusion Injury/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammasomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammasomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+Kidney+Injury%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute Kidney Injury/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+Kidney+Injury%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute Kidney Injury/prevention & control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+Kidney+Injury%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute Kidney Injury/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+Kidney+Injury%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute Kidney Injury/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Trypsin+Inhibitors%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Trypsin Inhibitors/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Trypsin+Inhibitors%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Trypsin Inhibitors/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Nossar LF</b>, Lopes JA, Pereira-Acácio A, Costa-Sarmento G, Rachid R, Wendt CHC, Miranda K, Galina A, Rodrigues-Ferreira C, Muzi-Filho H, Vieyra A. Chronic undernutrition impairs renal mitochondrial respiration accompanied by intense ultrastructural damage in juvenile rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(3277);'>Biochem Biophys Res Commun</em> 2024;<b>739</b>:150583. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39182354' target='_blank'>39182354</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbrc.2024.150583' target='_blank'>10.1016/j.bbrc.2024.150583</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbrc.2024.150583','39182354', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbrc.2024.150583' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3277);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.bbrc.2024.150583" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study investigated whether chronic undernutrition alters the mitochondrial structure and function in renal proximal tubule cells, thus impairing fluid transport and homeostasis. We previously showed that chronic undernutrition downregulates the renal proximal tubules (Na++K+)ATPase, the main molecular machine responsible for fluid transport and ATP consumption. Male rats received a multifactorial deficient diet, the so-called Regional Basic Diet (RBD), mimicking those used in impoverished regions worldwide, from weaning to a juvenile age (3 months). The diet has a low content (8 %) of poor-quality proteins, low lipids, and no vitamins compared to control (CTR). We investigated citrate synthase activity, mitochondrial respiration (oxygraphy) in phosphorylating and non-phosphorylating conditions with different substrates/inhibitors, potential across the internal membrane (Δψ), and anion superoxide/H2O2 formation. The data were correlated with ultrastructural alterations evaluated using transmission electron microscopy (TEM) and focused ion beam scanning electron microscopy (FIB-SEM). Citrate synthase activity decreased (∼50 %) in RBD rats, accompanied by a similar reduction in respiration in non-phosphorylating conditions, maximum respiratory capacity, and ATP synthesis. The Δψ generation and its dissipation after carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone remained unmodified in the survival mitochondria. H2O2 production increased (∼100 %) after Complex II energization. TEM demonstrated intense matrix vacuolization and disruption of cristae junctions in a subpopulation of RBD mitochondria, which was also demonstrated in the 3D analysis of FIB-SEM tomography. In conclusion, chronic undernutrition impairs mitochondrial functions in renal proximal tubules, with profound alterations in the matrix and internal membrane ultrastructure that culminate with the compromise of ATP supply for transport processes. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATP+synthesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATP synthesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chronic+undernutrition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chronic undernutrition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondrial+respiration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondrial respiration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondrial+ultrastructural+alterations%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondrial ultrastructural alterations</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Renal+mitochondria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Renal mitochondria</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fultrastructure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/ultrastructure</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malnutrition%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malnutrition/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malnutrition%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malnutrition/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malnutrition%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malnutrition/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Tubules%2c+Proximal%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Tubules, Proximal/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Tubules%2c+Proximal%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Tubules, Proximal/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Tubules%2c+Proximal%2fultrastructure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Tubules, Proximal/ultrastructure</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Citrate+(si)-Synthase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Citrate (si)-Synthase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Respiration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Respiration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fultrastructure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/ultrastructure</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Dorris ER</b>, Phelan DE, Russell J, Murphy M. Bone morphogenetic protein-3 is a negative regulator of transforming growth factor beta and fibrosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3277);'>Biochem Biophys Res Commun</em> 2024;<b>738</b>:150497. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39151293' target='_blank'>39151293</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbrc.2024.150497' target='_blank'>10.1016/j.bbrc.2024.150497</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbrc.2024.150497','39151293', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbrc.2024.150497' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3277);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1016/j.bbrc.2024.150497" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Fibrosis results in one-third of all deaths globally and is a major healthcare challenge. Fibrosis is scarring caused by the excess deposition of extracellular matrix proteins by fibroblasts. Inhibition of pathways downstream of transforming growth factor β (TGF-β) a pluripotent growth factor, has potent antifibrotic effects in different organs. Here we show that loss of bone morphogenetic protein (BMP-3) is a feature of kidney fibrosis, independent of the initiating injury, suggesting loss of this cytokine is a core fibrotic mechanism. TGF-β decreased BMP3 expression in human fibroblasts is possibly a feed-forward loop that contributes to increased and sustained TGF-β activity. Recombinant human BMP-3 reduced TGF-β induced fibroblast contraction, migration and invasion, pathways that lead to scarring and tissue stiffening. BMP-3 reduced TGF-β stimulated collagen cross-linking, and Ox-LDL receptor 1, a regulator of collagen deposition. BMP-3 inhibited TGF-β stimulated lysyl oxidase activity. Lysyl oxidase mediated collagen cross-linking is a critical process in TGF-β induced fibrosis. We propose that BMP-3 alters fibroblast responses to TGF-β, shifting the balance from fibrosis to repair. Recombinant human BMP-3 shows promise for development as a novel therapeutic for fibrosis. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22BMP-3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">BMP-3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lysyl+oxidase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lysyl oxidase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TGF-%ce%b2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TGF-β</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblasts%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblasts/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transforming+Growth+Factor+beta%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transforming Growth Factor beta/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Morphogenetic+Protein+3%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Morphogenetic Protein 3/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Morphogenetic+Protein+3%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Morphogenetic Protein 3/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein-Lysine+6-Oxidase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein-Lysine 6-Oxidase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein-Lysine+6-Oxidase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein-Lysine 6-Oxidase/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Collagen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Collagen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Duan Y</b>, Wang Q, Chen X, Deng G, Huang K, Sun F, Zhu J, Jiang K. Empagliflozin reduces renal calcium oxalate deposition in hyperoxaluria rats induced with ethylene glycol-ammonium chloride. <em class='incite-journal-name' onclick='ShowInCiteJournal(3277);'>Biochem Biophys Res Commun</em> 2024;<b>737</b>:150912. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39489113' target='_blank'>39489113</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbrc.2024.150912' target='_blank'>10.1016/j.bbrc.2024.150912</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbrc.2024.150912','39489113', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbrc.2024.150912' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3277);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.bbrc.2024.150912" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">A retrospective study reported that empagliflozin reduced the risk of urinary stone events in patients with diabetes mellitus. To further investigate empagliflozin's potential, we conducted an animal experiment to determine whether empagliflozin can prevent renal stone formation in hyperoxaluria rats. Hyperoxaluria rat models were constructed by administrating 0.75 % ethylene glycol and 1 % ammonium chloride in water. The empagliflozin-treated rats were gauged with empagliflozin at different concentrations, and their body weight and blood sugar data were recorded. After 30 days of treatment, we obtained 24-h urine, kidney, and blood samples. The urine samples were subjected to component detection. Blood samples were prepared for component detection and cytokines detection. Renal samples were subjected to von Kossa staining, transmission electron microscopy, immunohistochemistry, and transcriptome sequencing analysis. Results showed that in empagliflozin-treated hyperoxaluria rats, renal crystal deposition and mitochondria injury, urinary concentration, and excretion of oxalate were significantly decreased. Additionally, plasma levels of VEGF, IL-2, IL-1β, and MCP-1 were decreased. Immunohistochemistry showed that renal expression of KIM-1, MCP-1 was significantly decreased in empagliflozin-treated hyperoxaluria rats. Transcriptome sequencing of renal tissue represented that 25 genes were down-regulated while 12 were up-regulated in empagliflozin-treated hyperoxaluria rats. These regulated genes were mainly enriched in fatty acid metabolism, insulin resistance, muscle contraction, bile secretion, and parathyroid metabolism. Our animal experiments found that empagliflozin could reduce urinary concentration and excretion of oxalate and inhibit renal inflammation, then abating renal calcium oxalate deposition in hyperoxaluria rats in a non-diabetic state. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcium+oxalate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcium oxalate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Empagliflozin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Empagliflozin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+stones%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney stones</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prevention%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prevention</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sodium-glucose+cotransporter+2+inhibitor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sodium-glucose cotransporter 2 inhibitor</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ethylene+Glycol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ethylene Glycol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucosides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucosides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucosides%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucosides/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Benzhydryl+Compounds%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Benzhydryl Compounds/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperoxaluria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperoxaluria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperoxaluria%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperoxaluria/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcium+Oxalate%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcium Oxalate/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ammonium+Chloride%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ammonium Chloride</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sodium-Glucose+Transporter+2+Inhibitors%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sodium-Glucose Transporter 2 Inhibitors/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Hu D</b>, Wang L, Zhang Y, Liu X, Lu Z, Li H. Sanqi oral solution ameliorates renal fibrosis by suppressing fibroblast activation via HIF-1α/PKM2/glycolysis pathway in chronic kidney disease. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2024;<b>335</b>:118679. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39121930' target='_blank'>39121930</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118679' target='_blank'>10.1016/j.jep.2024.118679</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118679','39121930', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118679' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/12/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1016/j.jep.2024.118679" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Sanqi oral solution (SQ) is a traditional Chinese patent medicine, widely used to treat chronic kidney diseases (CKD) in the clinic in China. Previous studies have confirmed its anti-renal fibrosis effect, but the specific pharmacological mechanism is still unclear. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">Focusing on energy metabolism in fibroblasts, the renoprotective mechanism of SQ was investigated in vitro and in vivo. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Firstly, the fingerprint of SQ was constructed and its elementary chemical composition was analyzed. In the 5/6Nx rats experiment, the efficacy of SQ on the kidney was evaluated by detecting serum and urine biochemical indexes and pathological staining of renal tissues. Lactic acid and pyruvic acid levels in serum and renal tissues were detected. PCNA protein expression in kidney tissue was detected by immunofluorescence assay and Western blot. Expression levels of HIF-1α, PKM2 and HK2 were determined by immunohistochemistry, Western blot or RT-qPCR assay. In addition, the effect of SQ intervention on cell proliferation and glycolysis was evaluated in TGF-β1-induced NRK-49F cells, and the role of SQ exposure and HIF-1α/PKM2/glycolysis pathway were further investigated by silencing and overexpressing HIF-1α gene in NRK-49F cells. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">In 5/6 Nx rats, SQ effectively improved renal function and treated renal injury. It reduced the levels of lactic acid and pyruvic acid in kidney homogenates from CKD rats and decreased the expression levels of HIF-1α, PKM2, HK2, α-SMA, vimentin, collagen I and PCNA in kidney tissues. Similar results were observed in vitro. SQ inhibited NRK-49F cell proliferation, glycolysis and the expression levels of HIF-1α, PKM2 induced by TGF-β1. Furthermore, we established NRK-49F cells transfected with siRNA or pDNA to silence or overexpress the HIF-1α gene. Overexpression of HIF-1α promoted cellular secretion of lactic acid and pyruvic acid in TGF-β1-induced NRK-49F cells, however, this change was reversed by intervention with SQ or silencing the HIF-1α gene. Overexpression of HIF-1α can further induce increased PKM2 expression, while SQ intervention can reduce PKM2 expression. Moreover, PKM2 expression was also inhibited after silencing HIF-1α gene, and SQ was not effective even when given. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The mechanism of action of SQ was explored from the perspective of energy metabolism, and it was found to regulate PKM2-activated glycolysis, inhibit fibroblast activation, and further ameliorate renal fibrosis in CKD by targeting HIF-1α. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblast%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblast</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycolysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycolysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HIF-1%ce%b1%2fPKM2+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HIF-1α/PKM2 pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reno-protection%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reno-protection</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sanqi+oral+solution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sanqi oral solution</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypoxia-Inducible+Factor+1%2c+alpha+Subunit%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypoxia-Inducible Factor 1, alpha Subunit/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypoxia-Inducible+Factor+1%2c+alpha+Subunit%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypoxia-Inducible Factor 1, alpha Subunit/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Renal+Insufficiency%2c+Chronic%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Renal Insufficiency, Chronic/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Renal+Insufficiency%2c+Chronic%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Renal Insufficiency, Chronic/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibrosis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibrosis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblasts%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblasts/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycolysis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycolysis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thyroid+Hormone-Binding+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thyroid Hormone-Binding Proteins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyruvate+Kinase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyruvate Kinase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyruvate+Kinase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyruvate Kinase/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thyroid+Hormones%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thyroid Hormones</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Administration%2c+Oral%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Administration, Oral</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carrier+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carrier Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carrier+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carrier Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transforming+Growth+Factor+beta1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transforming Growth Factor beta1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transforming+Growth+Factor+beta1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transforming Growth Factor beta1/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Tian Y</b>, Tian R, He J, Guo Y, Yan P, Chen Y, Li R, Wang B. Toralactone alleviates cisplatin-induced acute kidney injury by modulating the gut microbiota-renal axis. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>142</b>:113115. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39276451' target='_blank'>39276451</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113115' target='_blank'>10.1016/j.intimp.2024.113115</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113115','39276451', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.113115' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/17/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1016/j.intimp.2024.113115" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Gut microbiota has been reported to be perturbed by cisplatin and to modulate the nephrotoxicity of chemotherapeutic agents. However, the critical role of toralactone, a bioactive components of Cassia obtusifolia L. seeds, in modulating the gut microbiota in the pathogenesis of cisplatin-induced nephrotoxicity remains to be elucidated. </div><div class="abstract-label">METHODS</div><div class="abstract-content">In this study, we verified the reno-protective effects of toralactone and compared the composition and function of the gut microbiota in the normal, cisplatin-treated and low or high dose of toralactone-treated mice using 16S rDNA gene sequencing. We also investigated the gut microbiota related LPS/TLR4/NF-κB/TNF-α pathway in renal tissue. To elucidate the causal relationship between gut dysbiosis and cisplatin nephrotoxicity, an antibiotic cocktail was administered to deplete the gut microbiota and fecal microbiota transplantation (FMT) was performed prior to cisplatin treatment. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The renal histopathology showed that toralactone significantly alleviated cisplatin-induced renal injury. 16S rDNA gene sequencing analysis demonstrated that toralactone treatment effectively reversed cisplatin-induced gut microbiota dysbiosis in mice. FMT from toralactone-treated mice to cisplatin-induced kidney injury mice was observed to have the reno-protective effects, and deletion of gut microbiota by antibiotics was found to negate the reno-protective effect of toralactone. Interestingly, the renal tissue of cisplatin-associated kidney injury mice showed activation of the LPS/TLR4/NF-κB pathway and increase in TNF-α within the renal tissue, whereas toralactone treatment was observed to inhibit the LPS/TLR4/NF-κB/TNF-α pathway. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">This study elucidated the reno-protective effects for the first time, demonstrating that it exerts its beneficial effects through the gut microbiota, which mediate the LPS/TLR4/NF-κB/TNF-α inflammatory pathway. It may help to develop therapeutic approaches using toralactone and targeted restoration of the gut microbiota. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cisplatin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cisplatin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gut+microbiota%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gut microbiota</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-%ce%baB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-κB</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nephrotoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nephrotoxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TLR4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TLR4</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toralactone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toralactone</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cisplatin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cisplatin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+Kidney+Injury%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute Kidney Injury/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+Kidney+Injury%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute Kidney Injury/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dysbiosis%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dysbiosis/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptor+4%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptor 4/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptor+4%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptor 4/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factor-alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factor-alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factor-alpha%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factor-alpha/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fecal+Microbiota+Transplantation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fecal Microbiota Transplantation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lactones%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lactones/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lactones%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lactones/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Wu D</b>, Li H, Wang L, Hu Y, Huang H, Li J, Yang Y, Wu X, Ye X, Mao R, Li J, Shi X, Xie C, Yang C. Echinocystic acid inhibits sepsis-associated renal inflammation and apoptosis by targeting protein tyrosine phosphatase 1B. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>142</b>:113076. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39298825' target='_blank'>39298825</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113076' target='_blank'>10.1016/j.intimp.2024.113076</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113076','39298825', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.113076' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.intimp.2024.113076" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Thefruits of Gleditsia sinensis Lam. have been utilized to treat inflammatory diseases in China. Echinocystic acid (EA), one pentacyclic triterpenoid isolated from thefruits of G. sinensis, exhibits an anti-inflammatory effect. However, its anti-sepsis activity and mechanism of action, especially the protective effect against sepsis-associated acute kidney injury (SA-AKI), are not investigated yet. This study is to explore the efficacy and potential mechanism of EA on SA-AKI. EA elevated the function of multiple organs and effectively reduced the increased inflammation and apoptosis of kidney tissue and HK-2 cells. DARTS, CETSA, and molecular docking experiments revealed that EA could directly bind to protein tyrosine phosphatase 1B (PTP1B), a widespread prototype non-receptor tyrosine phosphatase. Collectively, EA can alleviate murine SA-AKI though restraining inflammation and apoptosis and may be a potential natural drug for remedying SA-AKI. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Echinocystic+acid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Echinocystic acid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PTP1B%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PTP1B</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sepsis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sepsis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sepsis-associated+acute+kidney+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sepsis-associated acute kidney injury</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Tyrosine+Phosphatase%2c+Non-Receptor+Type+1%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Tyrosine+Phosphatase%2c+Non-Receptor+Type+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sepsis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sepsis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+Kidney+Injury%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute Kidney Injury/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+Kidney+Injury%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute Kidney Injury/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Docking+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Docking Simulation</a></li><li><a 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target="_blank">Oleanolic Acid/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Ibrahim H</b>, Sharawy MH, Hamed MF, Abu-Elsaad N. Peficitinib halts acute kidney injury via JAK/STAT3 and growth factors immunomodulation. <em class='incite-journal-name' onclick='ShowInCiteJournal(8802);'>Eur J Pharmacol</em> 2024;<b>984</b>:177020. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39349115' target='_blank'>39349115</a> DOI: <a href='https://dx.doi.org/10.1016/j.ejphar.2024.177020' target='_blank'>10.1016/j.ejphar.2024.177020</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ejphar.2024.177020','39349115', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ejphar.2024.177020' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8802);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/02/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1016/j.ejphar.2024.177020" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Acute Kidney Injury (AKI) is characterized by a sudden loss of kidney function and its management continues to be a challenge. In this study the effect of peficitinib, a Janus kinase inhibitor (JAKi), was studied in an aim to stop the progression of AKI at an early point of injury. Adult male mice were injected with aristolochic acid (AA) a single dose (10 mg/kg, i.p) to induce AKI. Peficitinib was injected in one of the two tested doses (5 or 10 mg/kg, i.p) 1 h after AA injection and was continued daily for seven days. Histopathological evaluation showed that peficitinib alleviated necrosis and hyaline cast formation induced by aristolochic acid. It decreased serum creatinine and the kidney injury molecule-1 (KIM-1) elevated by AA. Peficitinib also mitigated AA induced oxidative stress through regulating total antioxidant capacity (TAC) and reduced glutathione (GSH) level in renal tissue. Additionally, renal sections isolated from groups that received peficitinib revealed a decrease in vascular endothelial growth factor receptor 1 interstitial expression and transforming growth factor-beta 1 (TGF-β1) renal level. Peficitinib received groups showed a decrease in the active phosphorylated form of signal transducers and activators of transcription (STAT3). Moreover, peficitinib decreased renal protein levels and gene expression of the pro-inflammatory cytokines; interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and interferon gamma (IFN-γ). These findings suggest that peficitinib is helpful in halting AKI progression into chronic kidney disease through modulating JAK/STAT3 dependent inflammatory pathways and growth factors involved in normal glomerular function. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+kidney+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute kidney injury</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22JAK%2fSTAT%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">JAK/STAT</a></li><li><a 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Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Janus+Kinase+Inhibitors%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Janus Kinase Inhibitors/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Janus+Kinase+Inhibitors%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Janus Kinase Inhibitors/therapeutic use</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Huang H</b>, Huang S, Li C, Zhang C, Wang R, Wei L, Wu J, Mo P, Li Z, Li S, Chen J. Jian-Pi-Yi-Shen formula ameliorates renal fibrosis-induced anemia in rats with chronic kidney disease. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2024;<b>335</b>:118607. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39069029' target='_blank'>39069029</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118607' target='_blank'>10.1016/j.jep.2024.118607</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118607','39069029', 'Kidney/pathology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118607' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1016/j.jep.2024.118607" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Jian-Pi-Yi-Shen (JPYS) formula is an effective herbal therapy against renal injury, and JPYS has been clinically applied to ameliorate chronic kidney disease (CKD) and CKD-associated anemia. Increasing evidence supports the link between renal fibrosis and anemia in CKD. JPYS possessed anti-fibrosis effects in experimental CKD. Nevertheless, research on the mechanisms of JPYS in ameliorating renal anemia (RA) through suppressing renal fibrosis remains to be clarified. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">Our study here was carried out to investigate the mechanisms of JPYS in protecting against RA. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">An adenine-induced anemia model in rats with CKD at three different time points was established, and bio-samples taken from each group were analyzed. Biochemical analysis was employed to detect kidney function and hematological parameters. Masson staining was used to evaluate renal fibrosis of rats. Western blot and immunohistochemistry were utilized to evaluate the expressions of fibrotic markers, erythropoietin (EPO) and hypoxia inducible factor-2α (HIF-2α) in the kidneys of rats. Subsequently, transcriptomic analysis was conducted to disclose the possible mechanisms of JPYS in treating RA. Finally, the expression levels of key targets were analyzed and validated by using Western blot and enzyme-linked immunosorbent assay (ELISA). </div><div class="abstract-label">RESULTS</div><div class="abstract-content">JPYS treatment improved kidney function, suppressed renal fibrosis and enhanced hematological parameters in CKD rats. Moreover, JPYS treatment restored the increased expression levels of fibrotic markers and the declined EPO with time dependence. In parallel, data indicated JPYS treatment stimulated the translocation of HIF-2α into nucleus in the renal interstitium and thus promoted the expression of EPO. Transcriptomic profiling disclosed that activations of both nuclear factor kappa B (NF-κB) and transforming growth factor-β (TGF-β)/Smad pathways were closely associated with RA. Ultimately, experimental validation results presented that the increased expressions of target proteins from the above-mentioned two pathways in the kidneys were decreased significantly after JPYS treatment. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Our findings suggest that JPYS may improve RA by alleviating renal fibrosis, and the mechanisms of which involve in inhibiting the NF-κB and TGF-β/Smad pathways. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chronic+kidney+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chronic kidney disease</a></li><li><a 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style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Kidney/pathology (37889 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Kidney/pathology (37889 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>