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class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Zhang Y</b>, Wang B, Chen J, Li T. Role of exosomal miRNAs and macrophage polarization in gastric cancer: A novel therapeutic strategy. <em class='incite-journal-name' onclick='ShowInCiteJournal(8802);'>Eur J Pharmacol</em> 2025;<b>990</b>:177268. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39805486' target='_blank'>39805486</a> DOI: <a href='https://dx.doi.org/10.1016/j.ejphar.2025.177268' target='_blank'>10.1016/j.ejphar.2025.177268</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ejphar.2025.177268','39805486', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.ejphar.2025.177268' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8802);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/09/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/09/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/16/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.ejphar.2025.177268" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Gastric cancer (GC) is one of the most common gastrointestinal cancers worldwide, with consistently high morbidity and mortality rates and poor prognosis. Most patients are diagnosed at an advanced stage due to the lack of specific presentation in the early stages. Exosomes are a class of extracellular vesicles (EVs) widely found in body fluids and can release genetic material or multiple proteins to facilitate intercellular communication. In recent years, exosomal miRNAs have gained attention for their role in various cancers. These exosomal miRNAs can impact GC development and progression by targeting specific genes or influencing signaling pathways and cytokines involved in Angiogenesis, epithelial-mesenchymal transition (EMT), drug resistance, and immune regulation. They show great potential in terms of diagnosis, prognosis, and treatment of GC. Notably, the gastrointestinal tract has the largest number of macrophages, which play a significant role in GC progression. Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME) and can influence macrophage programming through various mediators, including macrophage polarization. Macrophage polarization is involved in inflammatory responses and significantly impacts the GC process. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microRNA</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor-Associated+Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor-Associated Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor-Associated+Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor-Associated Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelial-Mesenchymal+Transition%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelial-Mesenchymal Transition/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelial-Mesenchymal+Transition%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelial-Mesenchymal Transition/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+Activation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage Activation/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Zeng X</b>, Ma C, Fu W, Xu Y, Wang R, Liu D, Zhang L, Hu N, Li D, Li W. Changes in Type 1 Diabetes-Associated Gut Microbiota Aggravate Brain Ischemia Injury by Affecting Microglial Polarization Via the Butyrate-MyD88 Pathway in Mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(17033);'>Mol Neurobiol</em> 2025;<b>62</b>:3764-3780. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39322832' target='_blank'>39322832</a> DOI: <a href='https://dx.doi.org/10.1007/s12035-024-04514-9' target='_blank'>10.1007/s12035-024-04514-9</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12035-024-04514-9','39322832', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(2);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1007/s12035-024-04514-9' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17033);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1007/s12035-024-04514-9" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">People with type 1 diabetes (T1D) have a significantly elevated risk of stroke, but the mechanism through which T1D worsens ischemic stroke remains unclear. This study was aimed at investigating the roles of T1D-associated changes in the gut microbiota in aggravating ischemic stroke and the underlying mechanism. Fecal 16SrRNA sequencing indicated that T1D mice and mice with transplantation of T1D mouse gut microbiota had lower relative abundance of butyric acid producers, f_Erysipelotrichaceae and g_Allobaculum, and lower content of butyric acid in feces. After middle cerebral artery occlusion (MCAO), these mice had poorer neurological outcomes and more severe inflammation, but higher expression of myeloid differentiation factor 88 (MyD88) in the ischemic penumbra; moreover, the microglia were inclined to polarize toward the pro-inflammatory type. Administration of butyrate to T1D mice in the drinking water alleviated the neurological damage after MCAO. Butyrate influenced the response and polarization of BV2 and decreased the production of inflammatory cytokines via MyD88 after oxygen-glucose deprivation/reoxygenation. Knocking down MyD88 in the brain alleviated neurological outcomes and decreased the concentrations of inflammatory cytokines in the brain after stroke in mice with transplantation of T1D mouse gut microbiota. Poor neurological outcomes and aggravated inflammatory responses of T1D mice after ischemic stroke may be partly due to differences in microglial polarization mediated by the gut microbiota-butyrate-MyD88 pathway. These findings provide new ideas and potential intervention targets for alleviating neurological damage after ischemic stroke in T1D. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Butyric+acid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Butyric acid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gut+microbiota%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gut microbiota</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ischemic+stroke%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ischemic stroke</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MyD88%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MyD88</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Type+1+diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Type 1 diabetes</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a 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padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">81701288 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Program+for+Young+Talents+of+Basic+Research+in+Universities+of+Heilongjiang+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">YQJH2023028 Program for Young Talents of Basic Research in Universities of Heilongjiang Province</a></li></ul> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Li T</b>, Li Q, Liu S, Cao J, Mei J, Gong J, Chen J, Wang X, Zhang R, Li X, Wang Q, Zhang H, Wang B, Cao H, Yang H, Fung SY. Targeted V-type peptide-decorated nanoparticles prevent colitis by inhibiting endosomal TLR signaling and modulating intestinal macrophage polarization. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122843. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39321686' target='_blank'>39321686</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122843' target='_blank'>10.1016/j.biomaterials.2024.122843</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122843','39321686', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122843' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.biomaterials.2024.122843" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Inflammatory bowel disease (IBD) has become a serious and challenging health problem globally without curative medical treatments. Mounting evidence suggests that intestinal macrophages and their phenotypes are key players in the pathogenesis of IBD. Modulating the phenotypes and functions of intestinal macrophages through targeted interventions could be a promising approach to manage detrimental gut inflammation in IBD. In this study, we rationally design and fabricate a novel class of V-type peptide-decorated nanoparticles, VP-NP, with potent anti-inflammatory activity. Such a design allows two functional motifs FFD in a single peptide molecule to enhance the bioactivity of the nanoparticles. As expected, VP-NP exhibits a strong inhibitory activity on endosomal Toll-like receptor (TLR) signaling. Surprisingly, VP-NP can inhibit M1 polarization while facilitating M2 polarization in mouse bone marrow-derived macrophages through regulating the key transcription factors NF-κB, STAT1 and PPAR-γ. Mechanistically, VP-NP is internalized by macrophages in the endosomes, where it blocks endosomal acidification to inhibit endosomal TLR signaling; the transcriptomic analysis reveals that VP-NP potently down-regulates many genes in TLR, NF-κB, JAK-STAT, and cytokine/chemokine signaling pathways associated with inflammatory responses. In a colitis mouse model, the intraperitoneally administered VP-NP effectively alleviates the disease activities by decreasing colon inflammation and injuries, pro-inflammatory cytokine production, and myeloid cell infiltration in the gut. Furthermore, VP-NP primarily targets intestinal macrophages and alters their phenotypes from inflammatory M1-type toward the anti-inflammatory M2-type. This study provides a new nanotherapeutic strategy to specifically regulate macrophage activation and phenotypes through a dual mechanism to control gut inflammation, which may augment current clinical treatments for IBD. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+responses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory responses</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-like+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-like receptor</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endosomes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endosomes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestines%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestines/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestines%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestines/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Ma Y</b>, Huang Y, Liu X, Jiao L, Zhu H, Chen Z, Wu Z, Shen Y, Lin K, Hu F, Shu K. Aquaporin‑1 regulates microglial polarization and inflammatory response in traumatic brain injury. <em class='incite-journal-name' onclick='ShowInCiteJournal(11723);'>Int J Mol Med</em> 2025;<b>55</b>:41. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39749692' target='_blank'>39749692</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759584' target='_blank'>PMC11759584</a> DOI: <a href='https://dx.doi.org/10.3892/ijmm.2025.5482' target='_blank'>10.3892/ijmm.2025.5482</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3892/ijmm.2025.5482','39749692', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.3892/ijmm.2025.5482' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11723);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/04/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.3892/ijmm.2025.5482" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The present study investigated the mechanisms by which aquaporin 1 (AQP1) influences microglial polarization and neuroinflammatory processes in traumatic brain injury (TBI). A model of TBI was generated in AQP1‑knockout mice to assess the impact of AQP1 deletion on inflammatory cytokine release, neuronal damage and cognitive function. Immunofluorescence, reverse transcription‑quantitative PCR, western blotting and enzyme‑linked immunosorbent assay were employed to evaluate pro‑inflammatory and anti‑inflammatory markers. Behavioral assessments, including the Barnes maze, were performed to determine cognitive outcomes. Moreover, AQP1 knockout inhibited the activation of inflammation‑related signaling pathways, including nuclear factor‑κB, Janus kinase/signal transducer and activator of transcription, phosphoinositide 3‑kinase/protein kinase B and extracellular signal‑regulated kinase/mitogen‑activated protein kinase pathways. Further studies indicated that the AQP1 inhibitor m‑phenylenediacrylic acid demonstrated significant neuroprotective effects in a mouse model of TBI. These findings suggested that AQP1 may be essential in post‑TBI inflammatory responses and neuronal injury, establishing a theoretical foundation for future therapies aimed at AQP1. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AQP1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AQP1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TBI%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TBI</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microglia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microglia</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Injuries%2c+Traumatic%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Injuries, Traumatic/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Injuries%2c+Traumatic%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Injuries, Traumatic/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aquaporin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aquaporin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aquaporin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aquaporin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Sonoi R</b>, Kamihira M. Formation of epithelial polarity on the fluorinated-oil microdroplet surface by regulating cell adhesion. <em class='incite-journal-name' onclick='ShowInCiteJournal(12401);'>J Biosci Bioeng</em> 2025;<b>139</b>:234-241. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39800607' target='_blank'>39800607</a> DOI: <a href='https://dx.doi.org/10.1016/j.jbiosc.2024.12.009' target='_blank'>10.1016/j.jbiosc.2024.12.009</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jbiosc.2024.12.009','39800607', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.jbiosc.2024.12.009' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12401);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/17/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.jbiosc.2024.12.009" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Polarized epithelial cells are compartmentalized into apical and basement membranes with asymmetrically distributed proteins. This study aimed to establish a method for culturing epithelial cells at the fluorinated oil (Novec-7500) microdroplet surface for the formation of epithelial polarity, which is desirable for regenerative medicine and drug discovery research. Microdroplet surfaces treated with fibronectin, which regulates a variety of cell behaviors through direct interactions with cell surface integrin receptors, were prepared for culturing epithelial cells. The cells adhered rapidly to the fibronectin-coated fluorinated oil-medium interface and reached confluence. However, as the culture time progressed, the cells began to detach from the microdroplet surface. To promote adhesion to the microdroplet interface, the cells were exposed to the Rho-associated protein kinase inhibitor Y27632, which increased the frequency of microdroplets with cells adhering to the liquid-liquid interface by 1.63-fold. However, continuous exposure to Y27632 caused the cells to detach from the microdroplet surface. When the drug was switched from Y27632 to forskolin, which enhances cell-cell and cell-substrate adhesion, the cells remained as a monolayer on the microdroplet interface. Na+/K+-ATPase and zonula occludens-2 were localized to the apical and lateral membranes of the cells, respectively, while paxillin co-localized with fibronectin at the microdroplet interface. This suggests that the cells exhibited epithelial polarity. These findings indicate that the regulation of cell-cell and cell-substrate adhesion is crucial for establishing epithelial polarity in cells cultured on the microdroplet interface. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelial+polarity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelial polarity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibronectin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibronectin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liquid%e2%80%93liquid+interface%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liquid–liquid interface</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microdroplet%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microdroplet</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tight+junction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tight junction</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; 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padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Liu T</b>, Zhang L. GDF11 Mitigates Neuropathic Pain via Regulation of Microglial Polarization and Neuroinflammation through TGF-βR1/SMAD2/NF-κB Pathway in Male Mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(14644);'>J Neuroimmune Pharmacol</em> 2025;<b>20</b>:20. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39939465' target='_blank'>39939465</a> DOI: <a href='https://dx.doi.org/10.1007/s11481-025-10172-y' target='_blank'>10.1007/s11481-025-10172-y</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s11481-025-10172-y','39939465', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(6);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1007/s11481-025-10172-y' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14644);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/20/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/14/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1007/s11481-025-10172-y" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Spinal microglial activation and the polarization towards the M1 phenotype are implicated in the pathological process of neuropathic pain. Extensive research has elucidated that growth and differentiation factor 11 (GDF11), a constituent of the transforming growth factor-β (TGF-β) superfamily, exerts inhibitory effects on macrophage activation and mitigates inflammatory responses via the activation of TGF-β receptor type I (TGF-βR1). Nonetheless, the influence of GDF11 on spinal microglial polarization and its role in neuropathic pain remains to be ascertained. In the present investigation, a neuropathic pain model was induced via a spared nerve injury (SNI) procedure on the sciatic nerve in male mice. The impact of GDF11 on microglial polarization and neuropathic pain in SNI-subjected mice was evaluated through pain behavior assessments, WB, IF, qRT-PCR, and ELISA. Our findings revealed a significant downregulation of spinal GDF11 and TGF-βR1 expression levels in microglia of mice subjected to SNI. Furthermore, GDF11 treatment notably reversed the mechanical allodynia and thermal hyperalgesia, inhibited M1 microglial polarization, and attenuated neuroinflammatory processes by modulating the SMAD2/NF-κB in SNI mice. However, the analgesic effects of GDF11 on pain hypersensitivity and its modulatory influence on spinal microglial polarization were abrogated by the application of a specific antagonist of TGF-βR1, or the TGF-βR1 siRNA. In summary, GDF11 effectively ameliorated mechanical allodynia and thermal hyperalgesia, suppressed M1 microglial polarization, and alleviated neuroinflammation via the regulation of the TGF-βR1/SMAD2/NF-κB pathway in mice with SNI. These findings suggest that GDF11 holds promise as a therapeutic modality for the management of neuropathic pain. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GDF11%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GDF11</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglial+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglial polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuropathic+pain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuropathic pain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spinal+cord%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spinal cord</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Smad2+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Smad2 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuralgia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuralgia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Transforming+Growth+Factor-beta+Type+I%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Transforming Growth Factor-beta Type I/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Growth+Differentiation+Factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Growth Differentiation Factors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Morphogenetic+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Morphogenetic Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammatory+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammatory Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperalgesia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperalgesia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tongji+Hospital+Research+Fund+Project%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2024B20 Tongji Hospital Research Fund Project</a></li></ul> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Chen W</b>, Wu Z, Cheng Z, Zhang Y, Luo Q, Yin M. HO-1 represses NF-κB signaling pathway to mediate microglia polarization and phagocytosis in intracerebral hemorrhage. <em class='incite-journal-name' onclick='ShowInCiteJournal(17983);'>Neuroscience</em> 2025;<b>566</b>:17-27. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39672459' target='_blank'>39672459</a> DOI: <a href='https://dx.doi.org/10.1016/j.neuroscience.2024.12.020' target='_blank'>10.1016/j.neuroscience.2024.12.020</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.neuroscience.2024.12.020','39672459', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.neuroscience.2024.12.020' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17983);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.neuroscience.2024.12.020" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Microglia polarization plays a crucial role in inflammatory injury of brain following intracerebral hemorrhage (ICH). Heme oxygenase-1 (HO-1) has demonstrated protective properties against inflammation and promote hematoma clearance after ICH. The objective of this study was to explore impacts of HO-1 on microglia polarization and phagocytosis after ICH, along with the underlying mechanism. </div><div class="abstract-label">METHODS</div><div class="abstract-content">ICH model was constructed in C57BL/6 mice. Neurological deficit of ICH mice was evaluated. HE detected pathological changes of mouse brain tissue. Immunofluorescence staining tested co-localization between HO-1 or NF-κB p65 and IBA1. The expressions of gene and proteins were detected by RT-qPCR and Western blot, respectively. Flow cytometry determined microglial polarization phenotype and neuron apoptosis. Cell viability of neuron was assessed by CCK-8. Red blood cells labeled by PKH-26 and co-cultured with microglia for examining microglial erythrophagocytosis. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Both HO-1 and NF-κB p65 phosphorylation were elevated in brain tissues of ICH mice. ZnPP, a HO-1 inhibitor, could exacerbate microglial M1 polarization and nerve injury, as well as repress microglial erythrophagocytosis in vitro and hematoma clearance in vivo. On the contrary, Tat-NBD, a NF-κB inhibitor, greatly suppressed microglial M1 polarization, and induced M2 polarization and microglial erythrophagocytosis, thus improving nerve injury and hematoma clearance after ICH. Notably, it was observed that NF-κB p65 could be activated by ZnPP treatment, and the regulatory roles of ZnPP on microglial polarization and erythrophagocytosis after ICH in vivo and in vitro were all diminished by Tat-NBD. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Therefore, our data demonstrated that HO-1 alleviated nerve injury and induced M2 polarization and phagocytosis of microglia after ICH via inhibiting NF-κB signaling pathway, which could provide deepen the pathological understanding of ICH and provide potential intervention targets and drug candidate for ICH. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HO-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HO-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracerebral+hemorrhage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracerebral hemorrhage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-%ce%baB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-κB</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phagocytosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phagocytosis</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Hemorrhage%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Hemorrhage/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Hemorrhage%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Hemorrhage/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phagocytosis%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phagocytosis/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phagocytosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phagocytosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurons%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurons/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurons%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurons/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Proteins</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Álvarez MS</b>, Mazzei L, Hapon MB, Quesada I, Salvarredi L, Beltramo D, Castro C. New formulation of ibuprofen-arginate reduces oxidative stress and prevents macrophage polarization toward M1 phenotype. <em class='incite-journal-name' onclick='ShowInCiteJournal(3668);'>Biomed Pharmacother</em> 2025;<b>183</b>:117819. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39842270' target='_blank'>39842270</a> DOI: <a href='https://dx.doi.org/10.1016/j.biopha.2025.117819' target='_blank'>10.1016/j.biopha.2025.117819</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biopha.2025.117819','39842270', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.biopha.2025.117819' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3668);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/09/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/24/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.biopha.2025.117819" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">A hypertonic solution of Ibuprofen (Ibu) was designed to nebulize, associating a low concentration of Ibu with L-Arginine (AR), to increase solubility and serve as a nitric oxide donor. To provide preclinical research human bronchial epithelial cells derived from a cystic fibrosis patient homozygous for the ΔF508 CFTR mutation (CFBE41o-) and mouse RAW 264.7 macrophages were pre-treated with Ibu (10-100 μM), AR (20 and 200 μM), or the combination Ibu-AR (10-100 μM). After Angiotensin II (AngII) or LPS/Interferon ϒ (IFN) stimulation, Reactive Oxygen Species (ROS) generation, Nitric Oxide (NO) formation, and the expression of inflammatory markers were determined. Ibu-AR (10/20 μM) significantly reduced ROS generation stimulated by AngII (p < 0.01) in CFBE41o- cells preserved the NO pathway and inhibited LPS-stimulated nitrite generation (p < 0.001). In macrophages, the combination Ibu-Ar, in a ratio of 1:2-1:6, efficiently scavenged excessive ROS generated by LPS, and significantly induced NO generation (p < 0.001), but inhibited nitrite formation. In LPS/IFNϒ-activated Raw, gene signature of M1polarization including tumor necrosis factor (TNF-α), NADPH Oxidase 2 (NOX-2), MCP-1, and inducible nitric oxide synthase (iNOS) were significantly downregulated by Ibu-AR, as well TNF-α, IL-6, and iNOS protein expressions. The inhibitory effect produced by Ibu-AR on M1 macrophages was associated with the inhibition of p-ERK1/2 and p-STAT3. Ibu-AR represents an effective therapeutic strategy for reducing oxidative stress, preserving NO bioavailability, and modulating inflammation in chronic inflammatory diseases. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arginine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arginine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NSAIDs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NSAIDs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nitric+oxide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nitric oxide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative stress</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ibuprofen%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ibuprofen/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arginine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arginine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nitric+Oxide%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nitric Oxide/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Compounding%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Compounding</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Lokwani R</b>, Fertil D, Hartigan DR, Josyula A, Ngo TB, Sadtler K. Eosinophils Respond to Extracellular Matrix Treated Muscle Injuries but are Not Required for Macrophage Polarization. <em class='incite-journal-name' onclick='ShowInCiteJournal(1108);'>Adv Healthc Mater</em> 2025;<b>14</b>:e2400134. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39072935' target='_blank'>39072935</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834370' target='_blank'>PMC11834370</a> DOI: <a href='https://dx.doi.org/10.1002/adhm.202400134' target='_blank'>10.1002/adhm.202400134</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/adhm.202400134','39072935', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(9);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1002/adhm.202400134' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(1108);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1002/adhm.202400134" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The immune response to decellularized extracellular matrix (ECM) muscle injury is characterized by Th2 T cells, Tregs, M2-like macrophages, and an abundance of eosinophils. Eosinophils have previously been described as mediators of muscle regeneration but inhibit skin wound healing. In addition to response to wounding, a large number of eosinophils respond to biomaterial-treated muscle injury, specifically in response to decellularized ECM. ECM treatment of muscle wounds has been associated with positive outcomes in tissue regeneration, but the detailed mechanisms of action are still being evaluated. Here, this work investigates the role of these eosinophils in terms of their immunologic phenotype and subsequent effect on the local tissue microenvironment. These cells have a mixed phenotype showing both type-2 and regulatory gene upregulation and but are not required for macrophage polarization. Beyond the local tissue, ECM treatment is seen to induce a transient flux of eosinophils to the lungs but prevented a trauma-associated neutrophilia in the lungs of injured mice. This work believes this local and systemic immunomodulation contributes to the regenerative effects of the material and such distal tissue effects should be considered in therapeutic design and implementation. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22eosinophils%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">eosinophils</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunoengineering%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunoengineering</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22muscle+trauma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">muscle trauma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22wound+healing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">wound healing</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eosinophils%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eosinophils/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eosinophils%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eosinophils/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Matrix%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Matrix/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wound+Healing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wound Healing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intramural+Research+Program+of+the+National+Institutes+of+Health%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intramural Research Program of the National Institutes of Health</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIBIB+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NIBIB NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIBIB+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NIBIB NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Institute+of+Biomedical+Imaging+and+Bioengineering%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Institute of Biomedical Imaging and Bioengineering </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Institutes+of+Health%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Institutes of Health </a></li></ul> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>He Y</b>, Song W, Deng Y, Lin X, Gao Z, Ma P. Liraglutide promotes osteogenic differentiation of mesenchymal stem cells by inhibiting M1 macrophage polarization and CXCL9 release in vitro. <em class='incite-journal-name' onclick='ShowInCiteJournal(17380);'>Mol Cell Endocrinol</em> 2025;<b>597</b>:112441. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39706561' target='_blank'>39706561</a> DOI: <a href='https://dx.doi.org/10.1016/j.mce.2024.112441' target='_blank'>10.1016/j.mce.2024.112441</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.mce.2024.112441','39706561', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.mce.2024.112441' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17380);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/mce/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/23/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.mce.2024.112441" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">As a GLP-1 receptor agonist widely used in treating type 2 diabetes, liraglutide shows potential applications in bone tissue engineering. This study investigated liraglutide's direct effects on rat bone marrow mesenchymal stem cells (BMSCs) osteogenic differentiation and its regulatory mechanism through macrophage polarization. Results showed that liraglutide significantly enhanced BMSC migration and osteogenic differentiation. Additionally, liraglutide markedly inhibited M1 macrophage polarization induced by LPS and IFN-γ, reducing inflammatory factors CXCL9 and TNF-α secretion, possibly by partially reversing M1 macrophage regulatory signals (AMPK and NF-κB pathways). Compared to M1 macrophage-conditioned medium (M1-CM), conditioned medium from liraglutide-treated macrophages showed stronger promotion of BMSC osteogenic differentiation, though this effect was reversed by CXCL9 addition. The study demonstrates that liraglutide enhances BMSC osteogenic capacity both directly and by inhibiting M1 macrophage polarization and CXCL9 secretion, offering a new therapeutic option for severe bone defects with inflammatory responses. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CXCL9%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CXCL9</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liraglutide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liraglutide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemokine+CXCL9%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemokine CXCL9/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemokine+CXCL9%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemokine CXCL9/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liraglutide%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liraglutide/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a 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href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Zhan Q</b>, Wu Y, Li S, Zhang W, Xing L, Wei L, Zhao L. Effects of polysaccharide fractions isolated from the pulp of rose laevigata Michx fruit on the foaming and polarization of RAW264.7 macrophage cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(11467);'>Int J Biol Macromol</em> 2025;<b>291</b>:139074. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39716704' target='_blank'>39716704</a> DOI: <a href='https://dx.doi.org/10.1016/j.ijbiomac.2024.139074' target='_blank'>10.1016/j.ijbiomac.2024.139074</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ijbiomac.2024.139074','39716704', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.ijbiomac.2024.139074' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11467);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/25/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.ijbiomac.2024.139074" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The foaming and polarization of macrophages are pivotal in the formation and development of atherosclerosis. This study delved into the structure and membrane pattern recognition receptors (PRRs) of the neutral polysaccharide fraction (PPRLMF-1), investigating effects of PPRLMF-1 and acid polysaccharide fraction (PPRLMF-2) on the foaming and polarization of RAW264.7 macrophage cells, and exploring their underlying mechanisms. The results elucidated that PPRLMF-1, devoid of a triple-helix conformation, comprised rhamnose, arabinose, xylose, mannose, glucose and galactose in a molar ratio of 1: 4.04: 1.45: 3.91: 10.24: 5.83. The main PRRs of PPRLMF-1 in macrophages were CD36, CR3, TLR2, and TLR4. Comparing to PPRLMF-1, PPRLMF-2 demonstrated a superior ability to transform M0 and M2 phenotypic cells into M1 phenotype. Importantly, compared to PPRLMF-1, PPRLMF-2 exhibits superior ability in improving lipid accumulation and inflammatory state of foam cells, possibly achieved through inhibiting the intake of oxLDL. Consequently, PPRLMF-1 and PPRLMF-2 emerge as potential functional foods to prevent early atherosclerosis. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Foaming%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Foaming</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polysaccharide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polysaccharide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW264.7+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW264.7 cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rose+laevigata+Michx%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rose laevigata Michx</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polysaccharides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polysaccharides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polysaccharides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polysaccharides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polysaccharides%2fisolation+%26amp%3b+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polysaccharides/isolation & purification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fruit%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fruit/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rosa%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rosa/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Foam+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Foam Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Foam+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Foam Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoproteins%2c+LDL%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoproteins, LDL/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Ji SM</b>, Yoo H, Kim JI, Choi MJ, Cheon HG. Melatonin induces white-to-beige adipocyte transdifferentiation through melatonin receptor 1-mediated direct browning and indirect M2 polarization. <em class='incite-journal-name' onclick='ShowInCiteJournal(17380);'>Mol Cell Endocrinol</em> 2025;<b>597</b>:112439. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39653309' target='_blank'>39653309</a> DOI: <a href='https://dx.doi.org/10.1016/j.mce.2024.112439' target='_blank'>10.1016/j.mce.2024.112439</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.mce.2024.112439','39653309', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.mce.2024.112439' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17380);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/mce/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.mce.2024.112439" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Previous studies have shown that melatonin induces adipocyte browning in vivo. However, the underlying mechanisms of melatonin action at the cellular level remain elusive. In this study, we investigated the mechanisms underlying melatonin-induced browning in 3T3-L1 adipocytes and RAW 264.7 macrophages. Melatonin caused the transdifferentiation of fully differentiated white adipocytes into beige adipocytes, which involves the activation of melatonin receptor 1, followed by increased phosphorylation of p38 MAPK and Akt. Both luzindole (LZ), a non-selective melatonin receptor antagonist, and selective melatonin receptor 1 knockdown attenuated the browning effects of melatonin. Melatonin also induced M2 polarization in RAW 264.7, involving the melatonin receptor 1-Src-STAT3/STAT6 phosphorylation signaling cascade. Melatonin-treated M2-conditioned medium (CM) contained increased levels of catecholamine (CA) and induced beige adipocytes when treated with differentiated 3T3-L1 white adipocytes. In vivo oral administration of melatonin to high-fat diet (HFD)-induced obese (DIO) mice reduced body weight, accompanied by increased expression of uncoupling protein-1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in subcutaneous adipose tissues. Moreover, arginase-1 (Arg1) and mannose receptor C type-1 (MRC1) levels were markedly higher in the melatonin-treated groups, suggesting that melatonin induces adipose browning and M2 polarization in vivo. Collectively, melatonin-induced adipocyte browning appeared to be reflected by the sum of melatonin receptor 1-activated direct browning effects and indirect M2 polarization-mediated effects. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipocyte%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipocyte</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Browning%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Browning</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22M2+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">M2 polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melatonin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melatonin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melatonin+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melatonin receptor</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melatonin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melatonin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%223T3-L1+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">3T3-L1 Cells</a></li><li><a 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style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Wang Y</b>, Pu C, Han Z, Du Y, Chen L, Huang Y, Luo Y, Xiang C, He J, Chen L, Cui W, Jiang K, Li Y. In Situ Proefferocytosis Microspheres as Macrophage Polarity Converters Accelerate Osteoarthritis Treatment. <em>SMALL (WEINHEIM AN DER BERGSTRASSE, GERMANY)</em> 2025;<b>21</b>:e2405236. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39780612' target='_blank'>39780612</a> DOI: <a href='https://dx.doi.org/10.1002/smll.202405236' target='_blank'>10.1002/smll.202405236</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/smll.202405236','39780612', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(13);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1002/smll.202405236' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/11/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1002/smll.202405236" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Efferocytosis in macrophages typically engages an anti-inflammatory positive feedback regulatory mechanism. In osteoarthritis (OA), characterized by imbalanced inflammatory homeostasis, the proinflammatory state of macrophages in the immune microenvironment can be reversed through enhanced efferocytosis. This study develops an in situ proefferocytosis hydrogel microsphere (macrophage polarity converter, H-C@IL) for OA treatment. Immunoliposomes (IL), CD16/32 antibody-modified clodronate liposomes, are initially prepared using the Re-emulsion method. Then, the IL is loaded into CCL19-modified HAMA microspheres through microfluidic technology. In vitro, H-C@IL can specifically recruit M0 and M1 macrophages via CCL19, induce apoptosis in M1 macrophages through secondary targeting with IL, and provide "Find/Eat-me" signals to enhance in situ efferocytosis. Additionally, it promotes macrophage polarization toward the M2 phenotype. In vivo, behavioral, imaging, and histological analyses demonstrate that H-C@IL effectively facilitates macrophage polarization toward M2, inhibits inflammation, and promotes cartilage regeneration. Mechanistically, H-C@IL enhances efferocytosis by activating proteins such as PROS1 and TIMD4 in M0 macrophages. Concurrently, signaling pathways, including PQLC2-Arg-Rac1 and Pbx1/IL-10, are activated to drive the polarization of macrophages from M0 to M2. In summary, H-C@IL promotes M0 macrophage efferocytosis in situ, facilitates macrophage polarization toward M2, restores inflammatory homeostasis, and promotes cartilage regeneration, offering a comprehensive treatment strategy for OA. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22efferocytosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">efferocytosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hydrogel+microsphere%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hydrogel microsphere</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammatory+homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammatory homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a 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Affiliated Hospital of North Sichuan Medical College</a></li></ul> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Guo Y</b>, Zhao J, Liu X, Lu P, Liang F, Wang X, Wu J, Hai Y. Ghrelin Induces Ferroptosis Resistance and M2 Polarization of Microglia to Alleviate Neuroinflammation and Cognitive Impairment in Alzheimer's Disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(14644);'>J Neuroimmune Pharmacol</em> 2025;<b>20</b>:6. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39797928' target='_blank'>39797928</a> DOI: <a href='https://dx.doi.org/10.1007/s11481-024-10165-3' target='_blank'>10.1007/s11481-024-10165-3</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s11481-024-10165-3','39797928', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(14);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1007/s11481-024-10165-3' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14644);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/13/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1007/s11481-024-10165-3" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Microglial polarization and ferroptosis are important pathological features in Alzheimer's disease (AD). Ghrelin, a brain-gut hormone, has potential neuroprotective effects in AD. This study aimed to explore the potential mechanisms by which ghrelin regulates the progression of AD, as well as the crosstalk between microglial polarization and ferroptosis. Mouse BV2 microglial cells and male mice were treated with beta-amyloid (Aβ) (1-42) to simulate the AD environment. Microglia ferroptosis was measured by detecting levels of ferroptosis-related proteins (SLC7A11, GPX4, FTL1, and FTH1), metabolic markers (ROS, MDA, GSH, SOD), and observing mitochondrial morphological changes. Microglial polarization was evaluated by measuring levels of inflammatory markers and surface markers. The impact of ghrelin on Aβ1-42-exposed microglia was assessed by coupling with the ferroptosis activator Erastin. Cognitive impairment in AD mice was evaluated through behavioral tests. Tissue staining was applied to determine neuronal damage. In Aβ1-42-exposed microglia, ghrelin upregulated the protein expression of SLC7A11, GPX4, FTL1 and FTH1, reduced ROS and MDA levels, and elevated GSH and SOD levels through the BMP6/SMAD1 pathway. Ghrelin alleviated mitochondrial structural damage. Additionally, ghrelin reduced levels of pro-inflammatory factors and CD86, while increasing levels of anti-inflammatory factors and CD206. Erastin reversed the effects of ghrelin on ferroptosis and phenotypic polarization in Aβ1-42-exposed microglia. In AD mice, ghrelin ameliorated abnormal behavior, neuroinflammation, and plaque deposition. Ghrelin attenuated iNOS/IBA1-positive expression and enhanced Arg-1/IBA1-positive expression in the hippocampus. Ghrelin induces microglial M2 polarization by inhibiting microglia ferroptosis, thereby alleviating neuroinflammation. Our results indicate that ghrelin may serve as a promising potential agent for treating cognitive impairment in AD. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer%27s+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer's disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+impairment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive impairment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ghrelin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ghrelin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglial+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglial polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammation</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ghrelin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ghrelin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+Dysfunction%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive Dysfunction/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+Dysfunction%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive Dysfunction/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammatory+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammatory Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammatory+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammatory Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amyloid+beta-Peptides%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amyloid beta-Peptides/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptide+Fragments%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptide Fragments/toxicity</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+and+Technology+Plan+Project+of+Inner+Mongolia+Autonomous+Region%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2022YFSH0125 Science and Technology Plan Project of Inner Mongolia Autonomous Region</a></li></ul> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Feng X</b>, Yang C, Wang T, Zhang J, Zhou H, Ma B, Xu M, Deng G. IFN-τ Maintains Immune Tolerance by Promoting M2 Macrophage Polarization via Modulation of Bta-miR-30b-5p in Early Uterine Pregnancy in Dairy Cows. <em class='incite-journal-name' onclick='ShowInCiteJournal(4807);'>Cells</em> 2025;<b>14</b>:87. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39851515' target='_blank'>39851515</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764194' target='_blank'>PMC11764194</a> DOI: <a href='https://dx.doi.org/10.3390/cells14020087' target='_blank'>10.3390/cells14020087</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/cells14020087','39851515', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(15);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.3390/cells14020087' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4807);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/26/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.3390/cells14020087" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pregnancy failure in the first trimester of cows significantly impacts the efficiency of the dairy industry. As a type I interferon exclusively to ruminants, IFN-τ plays a key role in maternal recognition and immune tolerance of fetuses. Macrophages are the most common immune cells within the ruminant endometrium. Nevertheless, deeply analyzing the mechanisms of IFN-τ regulating macrophage polarization still needs further study. In this study, a notable decline of bta-miR-30b-5p expression via the increase of SOCS1 was observed in uterine tissues of pregnant cows. We then confirmed that the 3'UTR of SOCS1 was to be directly targeted by bta-miR-30b-5p. After that, we demonstrated that this obviously promoted the bovine macrophages (BoMac) polarized to M2 through enhancing SOCS1 expression with the treatment of IFN-τ. Furthermore, we found that SOCS1 restrained the expression of the key proteins p65 and p-P65 in the NF-κB pathway. Causing, the wide range of cross-species activities of IFN-τ, therefore we established a pregnant mouse model for the future confirmation of the above mechanism. The results verified that IFN-τ significantly improved this mechanism and maintained normal pregnancy status in mice, but miR-30b-5p significantly reduced the M2 polarization by inhibiting SOCS1, which activated the NF-κB signaling pathway, and then leading to the failure of embryo implantation. All these results indicated that IFN-τ can regulate immune tolerance during pregnancy by promoting M2 macrophage polarization through inhibiting bta-miR-30b-5p targeting SOCS1 to deactivate the NF-κB signaling pathway. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IFN-++++++++++++++++++++++++++++++++++++++++++++++++++++%cf%84%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IFN- τ</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22M2+macrophage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">M2 macrophage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SOCS1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SOCS1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bta-miR-30b-5p%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bta-miR-30b-5p</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pregnancy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pregnancy</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cattle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cattle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interferon+Type+I%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interferon Type I/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pregnancy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pregnancy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+Tolerance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune Tolerance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uterus%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uterus/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uterus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uterus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Suppressor+of+Cytokine+Signaling+1+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Suppressor of Cytokine Signaling 1 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Suppressor+of+Cytokine+Signaling+1+Protein%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Suppressor of Cytokine Signaling 1 Protein/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pregnancy+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pregnancy Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pregnancy+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pregnancy Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22The+National+Key+Research+and+Development+Program+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2023YFD1800804 The National Key Research and Development Program of China</a></li></ul> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Zhang J</b>, Tang S. Efficacy of caerulomycin A in modulating macrophage polarization and cytokine response in a murine model of lipopolysaccharide-induced sepsis. <em class='incite-journal-name' onclick='ShowInCiteJournal(8858);'>Eur J Med Res</em> 2025;<b>30</b>:22. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39794821' target='_blank'>39794821</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724434' target='_blank'>PMC11724434</a> DOI: <a href='https://dx.doi.org/10.1186/s40001-024-02265-w' target='_blank'>10.1186/s40001-024-02265-w</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s40001-024-02265-w','39794821', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1186/s40001-024-02265-w' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8858);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/13/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1186/s40001-024-02265-w" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Sepsis is characterized by an excessive immune response. Modulation of the immune response, particularly macrophage polarization, may provide therapeutic benefit. The effects of Caerulomycin A (caeA), a known STAT1 phosphorylation inhibitor, on macrophage polarization and inflammatory markers were explored using a lipopolysaccharide (LPS)-induced sepsis mouse model. </div><div class="abstract-label">METHODS</div><div class="abstract-content">A sepsis model was established in C57BL/6 mice induced by intraperitoneal injection of LPS, and the survival rate of mice was observed after treatment with different doses of caeA to determine the optimal therapeutic dose. For in-vitro assays using the RAW264.7 macrophage cell line, the concentration of caeA that was non-toxic to cell survival was screened using the MTT assay, followed by the analyses by qRT-PCR, ELISA, Western blot and flow cytometry for M1/M2 type macrophage markers (CD86, NOS2, CD206, ARG1) and inflammatory factors (IL-1β, IL-6, TNF-α, IL-4, and IL-10) expression. In addition, the phosphorylation levels of STAT1 and STAT6 in the JAK-STAT signaling pathway were detected. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The results of in-vivo experiments showed that caeA treatment (20 mg/kg) significantly increased the survival of LPS-induced septic mice and decreased the expression of M1-type macrophage markers (CD86 and NOS2) and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) while increasing the expression of M2-type markers (CD206 and ARG1) and anti-inflammatory cytokines (IL-4 and IL-10) expression. In in-vitro experiments, 20 μM caeA effectively inhibited LPS-induced polarization of M1-type macrophages without affecting the activity of RAW264.7 cells, and caeA significantly inhibited the phosphorylation of STAT1 yet enhanced the phosphorylation level of STAT6, as detected by Western blot. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">CaeA effectively modulates macrophage polarization and attenuates the inflammatory response in septic mice, possibly by affecting the JAK-STAT signaling pathway. These findings support further exploration of the potential of caeA as a therapeutic agent for sepsis. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caerulomycin+A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Caerulomycin A</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokine+modulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokine modulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunomodulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunomodulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sepsis+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sepsis therapy</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sepsis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sepsis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%222%2c2%27-Dipyridyl%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2,2'-Dipyridyl/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%222%2c2%27-Dipyridyl%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2,2'-Dipyridyl/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation+Mediators%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation Mediators/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22STAT1+Transcription+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">STAT1 Transcription Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Hao Y</b>, Duan F, Dong X, Bi R, Wang Y, Zhu S, Hu J. Gold Nanoparticle Inhibits the Tumor-Associated Macrophage M2 Polarization by Inhibiting m<sup>6</sup>A Methylation-Dependent ATG5/Autophagy in Prostate Cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(1861);'>Anal Cell Pathol (Amst)</em> 2025;<b>2025</b>:6648632. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39802931' target='_blank'>39802931</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724730' target='_blank'>PMC11724730</a> DOI: <a href='https://dx.doi.org/10.1155/ancp/6648632' target='_blank'>10.1155/ancp/6648632</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1155/ancp/6648632','39802931', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1155/ancp/6648632' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1155/ancp/6648632');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(1861);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/16/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1155/ancp/6648632" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Background: This study aims to study how gold nanoparticles (AuNPs) function in the recruitment and polarization of tumor-associated macrophages (TAMs) in hormone-sensitive prostate cancer (HSPC) and castration-resistant prostate cancer (CRPC). Methods: Phorbol ester (PMA)-treated THP-1 cells were cocultured with LNCaP or PC3 cells to simulate TAMs. Macrophage M2 polarization levels were detected using flow cytometry and M2 marker determination. ATG5 expression was detected by western blotting. Luciferase reporter assay was used to analyze the N6-methyladenosine (m6A) site activity of ATG5 3' untranslated regions (3'-UTRs). Methylated RNA immune precipitation (MeRIP)-quantitative polymerase chain reaction (qPCR) was performed to determine the m6A levels at ATG5 3'-UTR. Xenograft mouse models were used to determine the function of AuNPs in vivo. Results: Macrophages exhibited reduced M2 polarization in both HSPC and CRPC cells after AuNP treatment which was prevented by induction of autophagy. AuNP treatment decreased the m6A levels in the 3'-UTR of ATG5. Mutational analysis of potential m6A sites within ATG5 3'-UTR revealed that these sites were required for AuNP regulation, indicating that AuNPs inhibited ATG5 levels in an m6A-dependent manner. The mouse model revealed that AuNPs significantly reduced the M2 polarization of TAMs in an autophagy-dependent manner in vivo. This suggests that AuNPs inhibit tumor growth in vivo partially through targeting M2 TAM. Conclusion: The ATG5/autophagy pathway is inhibited by AuNP treatment in an METTL3/m6A-dependent manner. AuNPs inhibit the TAM M2 polarization in HSPC and CRPC by inhibiting ATG5/autophagy. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gold+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gold nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22m6A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">m6A</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prostate+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prostate cancer</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gold%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gold/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gold%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gold/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal+Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Protein+5%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Protein 5/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Protein+5%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Protein 5/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22THP-1+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">THP-1 Cells</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Cheng J</b>, He Y, Wang Z, Wang Z, Peng X, Zhang L. Neonatal Sevoflurane Exposure Exerts Sex-Specific Effects on Cognitive Function via C3- and TLR4-Related M1/M2 Microglial Cell Polarisation in Rats. <em class='incite-journal-name' onclick='ShowInCiteJournal(12461);'>J Cell Mol Med</em> 2025;<b>29</b>:e70311. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39873265' target='_blank'>39873265</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774238' target='_blank'>PMC11774238</a> DOI: <a href='https://dx.doi.org/10.1111/jcmm.70311' target='_blank'>10.1111/jcmm.70311</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/jcmm.70311','39873265', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(18);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1111/jcmm.70311' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12461);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/30/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1111/jcmm.70311" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">In this study, we aimed to explore the sex-specific effects and mechanisms of sevoflurane exposure on the neural development of pubertal rats on the basis of M1/M2 microglial cell polarisation and related signalling pathways. A total of 48 rat pups (24 males and 24 females) were assigned to the 0- or 2-h sevoflurane exposure group on the seventh day after birth. The Morris water maze (MWM) test was subsequently conducted on the 32nd to 38th days after birth. M1/M2 microglial cell polarisation, C3 and TLR4 expression, and synapse growth were analysed within specific brain zones by immunofluorescence after the MWM test. We found that the negative effects caused by sevoflurane exposure were weaker in female rats than in male rats and had less influence on spatial memory. Sevoflurane exposure has opposite effects on microglial M1 polarisation in the different sexes but can promote M2 polarisation, with more obvious effects seen in female rats. In addition, sevoflurane exposure had bidirectional effects on C3 expression in different zones, while it clearly downregulated C3 expression in female rats. Moreover, sevoflurane decreased TLR4 expression in the hippocampus, whereas female rats exhibited better resistance, especially in the dentate gyrus. Compared with male rats, female rats were more resistant to the synaptic reduction effect of sevoflurane exposure. In conclusion, we found that neonatal sevoflurane exposure could exhibit sex-specific effects via the regulation of C3- and TLR4-related microglial cell polarisation. In addition, subregional regulation in the hippocampus might also contribute to its sex-specific effects. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+Function%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive Function</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Complement+3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Complement 3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglial+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglial cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll%e2%80%90like+receptor+4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll‐like receptor 4</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sevoflurane%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sevoflurane/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptor+4%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptor 4/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%2c+Newborn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals, Newborn</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognition%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognition/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sex+Characteristics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sex Characteristics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sex+Factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sex Factors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Maze+Learning%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Maze Learning/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22The+Funding+of+Scientific+Research+Projects+from+Wuhan+Municipal+Health+Commission%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">WX23B05 The Funding of Scientific Research Projects from Wuhan Municipal Health Commission</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clinical+Project+of+Wu+Jieping+Medical+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">320.6750.2022-11-6 Clinical Project of Wu Jieping Medical Foundation</a></li></ul> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Sun M</b>, Liu Y, Wang X, Wang L. HPGD: An Intermediate Player in Microglial Polarization and Multiple Sclerosis Regulated by Nr4a1. <em class='incite-journal-name' onclick='ShowInCiteJournal(17033);'>Mol Neurobiol</em> 2025;<b>62</b>:271-287. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38842672' target='_blank'>38842672</a> DOI: <a href='https://dx.doi.org/10.1007/s12035-024-04280-8' target='_blank'>10.1007/s12035-024-04280-8</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12035-024-04280-8','38842672', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1007/s12035-024-04280-8' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17033);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/15/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/07/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1007/s12035-024-04280-8" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">HPGD encodes 15-Hydroxyprostaglandin dehydrogenase catalyzing the decomposition of prostaglandin E2 and has not been reported in multiple sclerosis (MS). We previously found that Nr4a1 regulated microglia polarization and inhibited the progression of experimental autoimmune encephalomyelitis (EAE). Bioinformatics analysis suggested that HPGD might be regulated by Nr4a1. Therefore, this study aimed to explore the role of HPGD in microglia polarization and determine whether HPGD mediates the inhibition of EAE by Nr4a1. C57BL/6 mice were treated with MOG35-55 peptide to induce EAE. BV-2 cells were treated with LPS/IL-4 to induce M1/M2 polarization. We then analyzed the pathological changes of spinal cord tissue, detected the expression levels of M1/M2 genes in tissues and cells, and explored the effect of HPGD on PPARγ activation to clarify the role of HPGD in EAE. The interaction between HPGD and Nr4a1 was verified by ChIP and pull-down assay. HPGD was downregulated in the spinal cord of EAE mice and HPGD overexpression alleviated the progression of EAE. Experiments in vitro and in vivo revealed that HPGD inhibited M1 polarization, promoted M2 polarization and increased PPARγ-DNA complex level. Nr4a1 could bind to the promoter of HPGD and its overexpression increased HPGD level. HPGD overexpression (or knockdown) reversed the effect of Nr4a1 knockdown (or overexpression) on M1/2 polarization. HPGD is regulated by Nr4a1 and inhibits the progression of EAE through shifting the M1/M2 polarization and promoting the activation of PPARγ signaling pathway. This study provides potential targets and basis for the development of MS therapeutic drugs. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HPGD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HPGD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiple+sclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiple sclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nr4a1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nr4a1</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Encephalomyelitis%2c+Autoimmune%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Encephalomyelitis, Autoimmune, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Encephalomyelitis%2c+Autoimmune%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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id="citation20" class="article-citation"> <b>Shi M</b>, Yang J, Liu Y, Zhao H, Li M, Yang D, Xie Q. Huanglian Wendan Decoction Improves Insomnia in Rats by Regulating BDNF/TrkB Signaling Pathway Through Gut Microbiota-Mediated SCFAs and Affecting Microglia Polarization. <em class='incite-journal-name' onclick='ShowInCiteJournal(17033);'>Mol Neurobiol</em> 2025;<b>62</b>:1047-1066. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38954253' target='_blank'>38954253</a> DOI: <a href='https://dx.doi.org/10.1007/s12035-024-04330-1' target='_blank'>10.1007/s12035-024-04330-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12035-024-04330-1','38954253', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(20);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1007/s12035-024-04330-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17033);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1007/s12035-024-04330-1" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Insomnia is a typical type of sleep disorder. Huanglian Wendan Decoction (HWD) is a traditional Chinese medicine (TCM) with the effects of regulating Qi, drying dampness and resolving phlegm, calming the mind, and relieving irritation. This study aims to investigate the effect of HWD on insomnia in rats and its mechanism. Para-chlorophenylalanine (PCPA)-induced insomnia in rats was used for in vivo experiments and then treated with HWD. Behavioral tests, Western blot, real-time PCR, immunofluorescent staining, 16S rRNA sequencing were conducted. The content of SCFAs was determined by GC-MS. Acetic acid-pretreated rat hippocampal nerve cells were used for in vitro experiments. The results showed that HWD significantly improved the learning memory ability, decreased sleep latency, and prolonged sleep duration in insomniac rats. HWD reduced TNF-α and IL-6 levels and increased IL-10 and Foxp3 levels. HWD also promoted the polarization of macrophages from M1 pro-inflammatory phenotype to M2 anti-inflammatory phenotype. In addition, HWD increased the expression levels of BDNF and TrkB in the hippocampus. Administration of the TrkB receptor agonist 7,8-dihydroxyflavone (7,8-DHF) confirmed the mechanism by which HWD activates BDNF/TrkB signaling to ameliorate insomnia. Furthermore, HWD restored gut microbiota richness and diversity and promoted short-chain fatty acid (SCFA) production in insomniac rats. In vitro experiments confirmed that the acetic acid-treated SCFA group could activate the BDNF/TrkB signaling pathway in neuronal cells, further promoting neuronal cell growth. In conclusion, HWD alleviated insomnia by maintaining gut microbiota homeostasis, promoting SCFA production, reducing neuroinflammatory response and microglia activation, and activating BDNF/TrkB signaling pathway. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%225-Hydroxytryptamine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">5-Hydroxytryptamine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain-gut+axis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain-gut axis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sleep+disorder%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sleep disorder</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Traditional+Chinese+medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Traditional Chinese medicine</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sleep+Initiation+and+Maintenance+Disorders%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sleep Initiation and Maintenance Disorders/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sleep+Initiation+and+Maintenance+Disorders%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sleep Initiation and Maintenance Disorders/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain-Derived+Neurotrophic+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain-Derived Neurotrophic Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+trkB%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, trkB/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Acids%2c+Volatile%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Acids, Volatile/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%5c%22Xinglin+Scholar%5c%22+Plan+of+Chengdu+University+of+Traditional+Chinese+Medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MPRC2022011 "Xinglin Scholar" Plan of Chengdu University of Traditional Chinese Medicine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+and+Technology+Department+of+Sichuan+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2023NSFSC1767 Science and Technology Department of Sichuan Province</a></li></ul> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Sasaki K</b>, Fujita H, Sato T, Kato S, Takahashi Y, Takeshita Y, Kanda T, Saito T, Saido TC, Hattori S, Hozumi Y, Yamada Y, Waki H. GLP-1 receptor signaling restores aquaporin 4 subcellular polarization in reactive astrocytes and promotes amyloid β clearance in a mouse model of Alzheimer's disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(3277);'>Biochem Biophys Res Commun</em> 2024;<b>741</b>:151016. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39577079' target='_blank'>39577079</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbrc.2024.151016' target='_blank'>10.1016/j.bbrc.2024.151016</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbrc.2024.151016','39577079', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.bbrc.2024.151016' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3277);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/24/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1016/j.bbrc.2024.151016" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The physiological actions of a gut hormone, glucagon-like peptide-1 (GLP-1), in Alzheimer's disease (AD) brain remain poorly understood, although GLP-1 receptor (GLP-1R) expression in this organ has been shown in several experimental studies. Therefore, we explored whether the GLP-1R signaling promotes the clearance of amyloid β (Aβ) (1-42) which is a core pathological hallmark of AD, focusing on the water channel protein aquaporin 4 (AQP4) localized to astrocyte endfeet perivascular membranes in intact brain. First, we confirmed that Glp1r mRNA is predominantly expressed at perivascular site of astrocytes in normal mouse cerebral cortex through in situ hybridization analysis. Next, we observed that 20-week subcutaneous administration of a GLP-1R agonist (GLP-1RA) liraglutide significantly reduced Aβ (1-42) accumulation in the cerebral cortex and improved spatial working memory in an AD mouse model, AppNL-G-F/NL-G-F mice. Furthermore, our current data revealed that the 4-week liraglutide treatment relocalized subcellular AQP4 in morphologically injured reactive astrocytes of AppNL-G-F/NL-G-F mice to the cell surface perivascular site through PKA-mediated AQP4 phosphorylation. Such translocation of phosphorylated AQP4 to astrocyte cell surface following incubation with liraglutide was observed also in the present in vitro study using the cell line in which AQP4 cDNA was introduced into immortalized human astrocyte. These results suggest that enhanced intracerebral GLP-1R signaling following peripheral administration of GLP-1RA restores AQP4 subcellular polarization in reactive astrocytes and would promote Aβ excretion possibly through increasing AQP4-mediated intracerebral water flux in the brain in AD. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer%27s+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer's disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amyloid+%ce%b2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amyloid β</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aquaporin+4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aquaporin 4</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Astrocyte%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Astrocyte</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GLP-1+receptor+signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GLP-1 receptor signaling</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aquaporin+4%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aquaporin 4/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aquaporin+4%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aquaporin 4/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Astrocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Astrocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Astrocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Astrocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amyloid+beta-Peptides%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amyloid beta-Peptides/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucagon-Like+Peptide-1+Receptor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucagon-Like Peptide-1 Receptor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucagon-Like+Peptide-1+Receptor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucagon-Like Peptide-1 Receptor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liraglutide%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liraglutide/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Transgenic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Transgenic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Cortex%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Cortex/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Cortex%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Cortex/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebral+Cortex%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebral Cortex/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Park HJ</b>, Lee SC, Park SH. Norepinephrine stimulates M2 macrophage polarization via β2-adrenergic receptor-mediated IL-6 production in breast cancer cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(3277);'>Biochem Biophys Res Commun</em> 2024;<b>741</b>:151087. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39616942' target='_blank'>39616942</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbrc.2024.151087' target='_blank'>10.1016/j.bbrc.2024.151087</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbrc.2024.151087','39616942', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.bbrc.2024.151087' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3277);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1016/j.bbrc.2024.151087" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Previous studies have demonstrated that norepinephrine (NE) released during chronic stress promotes breast cancer (BC) metastasis via adrenergic receptors (ARs). However, the effect of NE on tumor-associated macrophage polarization and the underlying mechanisms remain largely unknown. In this study, we aimed to investigate the influence of NE on M2 macrophage polarization, with a particular focus on the crosstalk between macrophages and BC cells. Our results demonstrated that, although NE alone did not directly induce the expression of M2 macrophage markers, conditioned medium from NE-treated MDA-MB-231 human BC cells (NE CM) significantly promoted M2 macrophage polarization in THP-1 macrophages. We found that NE stimulated IL-6 production in MDA-MB-231 cells via β2-AR/NF-κB pathway, which activated STAT3 in THP-1 cells to induce M2 macrophage polarization. NE failed to induce IL-6 production and NF-κB activation when ADRB2 was knocked down in MDA-MB-231 cells. Furthermore, ADRB2 knockdown in cancer cells suppressed NE CM-induced M2 macrophage polarization, as well as M2 macrophage-induced cancer cell migration. Taken together, our results suggest that NE stimulates M2 macrophage polarization by inducing IL-6 secretion from BC cells through a β2-AR-dependent mechanism, which subsequently promotes cancer cell migration. Targeting β2-AR may represent a promising strategy to prevent chronic stress-induced BC metastasis. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+migration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer migration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-6%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-6</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22M2+macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">M2 macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Norepinephrine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Norepinephrine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%ce%b22-adrenergic+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">β2-adrenergic receptor</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-6%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-6/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Norepinephrine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Norepinephrine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Adrenergic%2c+beta-2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Adrenergic, beta-2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Adrenergic%2c+beta-2%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Adrenergic, beta-2/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22STAT3+Transcription+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">STAT3 Transcription Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Movement%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Movement/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+Activation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage Activation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22THP-1+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">THP-1 Cells</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Penninger P</b>, Brezovec H, Tsymala I, Teufl M, Phan-Canh T, Bitencourt T, Brinkmann M, Glaser W, Ellmeier W, Bonelli M, Kuchler K. HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2024;<b>43</b>:114993. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39580799' target='_blank'>39580799</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.114993' target='_blank'>10.1016/j.celrep.2024.114993</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.114993','39580799', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.114993' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/26/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.celrep.2024.114993" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Histone deacetylases (HDACs) contribute to shaping many aspects of T cell lineage functions in anti-infective surveillance; however, their role in fungus-specific immune responses remains poorly understood. Using a T cell-specific deletion of HDAC1, we uncover its critical role in limiting polarization toward Th17 by restricting expression of the cytokine receptors gp130 and transforming growth factor β receptor 2 (TGF-βRII) in a fungus-specific manner, thus limiting Stat3 and Smad2/3 signaling. Controlled release of interleukin-17A (IL-17A) and granulocyte-macrophage colony-stimulating factor (GM-CSF) is vital to minimize apoptotic processes in renal tubular epithelial cells in vitro and in vivo. Consequently, animals harboring excess Th17-polarized HDCA1-deficient CD4+ T cells develop increased kidney pathology upon invasive Candida albicans infection. Importantly, pharmacological inhibition of class I HDACs similarly increased IL-17A release by both mouse and human CD4+ T cells. Collectively, this work shows that HDAC1 controls T cell polarization, thus playing a critical role in the antifungal immune defense and infection outcomes. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD4(%2b)+T%c2%a0cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD4(+) T cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Immunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Th17%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Th17</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22histone+deacetylase+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">histone deacetylase 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22kidney+function%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">kidney function</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22systemic+fungal+infection%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">systemic fungal infection</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histone+Deacetylase+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histone Deacetylase 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Th17+Cells%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Th17 Cells/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Th17+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Th17 Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Candida+albicans%2fpathogenicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Candida albicans/pathogenicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-17%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-17/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Candidiasis%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Candidiasis/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Candidiasis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Candidiasis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22STAT3+Transcription+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">STAT3 Transcription Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Granulocyte-Macrophage+Colony-Stimulating+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Granulocyte-Macrophage Colony-Stimulating Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Xia M</b>, Yi M, Guo C, Xie Y, Yu W, Wang D, Dai X. β-Asarone regulates microglia polarization to alleviate TBI-induced nerve damage via Fas/FasL signaling axis. <em class='incite-journal-name' onclick='ShowInCiteJournal(10514);'>Hum Cell</em> 2024;<b>38</b>:33. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39718669' target='_blank'>39718669</a> DOI: <a href='https://dx.doi.org/10.1007/s13577-024-01161-z' target='_blank'>10.1007/s13577-024-01161-z</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s13577-024-01161-z','39718669', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1007/s13577-024-01161-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10514);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/25/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1007/s13577-024-01161-z" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Acute injury and secondary injury caused by traumatic brain injury (TBI) seriously threaten the health of patients. The purpose of this study was to investigate the role of β-Asarone in TBI-induced neuroinflammation and injury. In this work, the effects of β-Asarone on nerve injury and neuronal apoptosis were investigated in mice with TBI by controlled cortical impingement. The results of this research implied that β-Asarone dose-dependently decreased the mNSS score, brain water content and neuronal apoptosis, but increased the levels of the axonal markers Nrp-1 and Tau in TBI mice. In addition, β-Asarone caused a decrease in the levels of Fas, FasL, and inflammatory factors in cerebrospinal fluid and serum of TBI mice. Therefore, β-Asarone inhibited neuroinflammation and promoted axon regeneration in TBI mice. Besides, β-Asarone treatment inhibited M1 phenotype polarization but promoted M2 phenotype polarization in microglia of TBI mice. Overexpression of Fas and FasL reversed the above effects of β-Asarone. Thus, β-Asarone regulated microglial M1/M2 polarization balance in TBI mice by suppressing Fas/FasL signaling axis. In conclusion, β-Asarone inhibited Fas/FasL signaling pathway to promote the M1/M2 polarization balance of microglia toward M2 polarization, thus alleviating TBI-induced nerve injury. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fas%2fFasL+signaling+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fas/FasL signaling pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22M1%2fM2+polarization+of+microglia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">M1/M2 polarization of microglia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Traumatic+brain+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Traumatic brain injury</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%ce%b2-Asarone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">β-Asarone</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Allylbenzene+Derivatives%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Allylbenzene Derivatives/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anisoles%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anisoles/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fas+Ligand+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fas Ligand Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22fas+Receptor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">fas Receptor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22fas+Receptor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">fas Receptor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Injuries%2c+Traumatic%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Injuries, Traumatic/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Injuries%2c+Traumatic%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Injuries, Traumatic/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammatory+Diseases%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammatory Diseases/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammatory+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammatory Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Major+Science+and+Technology+Projects+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2020SK1014 National Major Science and Technology Projects of China</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Kovacs T</b>, Cs. Szabo B, Kothalawala RC, Szekelyhidi V, Nagy P, Varga Z, Panyi G, Zakany F. Inhibition of the H<sub>V</sub>1 voltage-gated proton channel compromises the viability of human polarized macrophages in a polarization- and ceramide-dependent manner. <em class='incite-journal-name' onclick='ShowInCiteJournal(9345);'>Front Immunol</em> 2024;<b>15</b>:1487578. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39742270' target='_blank'>39742270</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685079' target='_blank'>PMC11685079</a> DOI: <a href='https://dx.doi.org/10.3389/fimmu.2024.1487578' target='_blank'>10.3389/fimmu.2024.1487578</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fimmu.2024.1487578','39742270', 'Cell Polarity/drug effects')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.3389/fimmu.2024.1487578' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fimmu.2024.1487578');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9345);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/03/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.3389/fimmu.2024.1487578" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The human voltage-gated proton channel (HV1) provides an efficient proton extrusion pathway from the cytoplasm contributing to the intracellular pH regulation and the oxidative burst. Although its pharmacological inhibition was previously shown to induce cell death in various cell types, no such effects have been examined in polarized macrophages albeit HV1 was suggested to play important roles in these cells. This study highlights that 5-chloro-2-guanidinobenzimidazole (ClGBI), the most widely applied HV1 inhibitor, reduces the viability of human THP-1-derived polarized macrophages at biologically relevant doses with M1 macrophages being the most, and M2 cells the least sensitive to this compound. ClGBI may exert this effect principally by blocking HV1 since the sensitivity of polarized macrophages correlates well with their HV1 expression levels; inhibitors of other macrophage ion channels that may be susceptible for off-target ClGBI effects cause no viability reductions; and Zn2+, another non-specific HV1 blocker, exerts similar effects. As a potential mechanism behind the ClGBI-induced cell death, we identify a complex pH dysregulation involving acidification of the cytoplasm and alkalinization of the lysosomes, which eventually result in membrane ceramide accumulation. Furthermore, ClGBI effects are alleviated by ARC39, a selective acid sphingomyelinase inhibitor supporting the unequivocal significance of ceramide accumulation in the process. Altogether, our results suggest that HV1 inhibition leads to cellular toxicity in polarized macrophages in a polarization-dependent manner, which occurs due to a pH dysregulation and concomitant ceramide overproduction mainly depending on the activity of acid sphingomyelinase. The reduced macrophage viability and plausible concomitant changes in homeostatic M1-M2 balance could contribute to both the therapeutic and potential side effects of HV1 inhibitors that show great promise in the treatment of neuroinflammation and malignant diseases. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HV1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HV1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22M1+macrophages%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">M1 macrophages</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22M2+macrophages%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">M2 macrophages</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22acid+sphingomyelinase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">acid sphingomyelinase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+viability%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell viability</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ceramide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ceramide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pH+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pH regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">polarization</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ion+Channels%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ion Channels/metabolism</a></li><li><a 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style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Cell Polarity/drug effects (841 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Cell Polarity/drug effects (841 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:455px;width:420px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:14pt;font-style:italic;border-bottom-style:Solid;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Welcome to Reference Citation Analysis</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1691100642" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>