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RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> </head> <body> <form method="post" action="./search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" id="form1"> <div class="aspNetHidden"> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" 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OpenBatchFriendMessage(friendIds); } } } function ImportSingleArticle(doi, controlId) { if (doi != '') { LoadingPanel.Show(); var uri = "/api/BpgUser/ImportArticle?doiPmid=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function (data) { LoadingPanel.Hide(); if (data) { alert("Import Successfully!"); var currentControl = $("#" + controlId); currentControl.parent().hide(); } }).always(function () { LoadingPanel.Hide(); }); } } function ImportAllArticles() { LoadingPanel.Show(); var term = getQueryString2('term'); var uri = "/api/BpgUser/ImportArticlesFromSearch?term=" + term; $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function () { LoadingPanel.Hide(); alert("Imorting is executing!"); }).always(function () { LoadingPanel.Hide(); }); } </script> <input type="hidden" name="ctl00$RootHolder$RCAId" id="RCAId" /> <input type="hidden" name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">2780</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (796)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (1776)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Autophagy/genetics</label> </div> <div 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name="sortedbycheck" value="aisorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('ai')" id="aisorted">Impact Index Per Article</a> </li> <li> <input type="radio" id="citedf6sortedCheck" onclick="SetSorted('citedf6')" name="sortedbycheck" value="citedf6sorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('citedf6')" id="citedf6sorted"> Citation(s) in <i>RCA</i> </a> </li> </ul> </div> <div id="RootHolder_ResultsAnalysisContainer"> <div class="mnavbar"> <div> Results Analysis </div> </div> <div class="mnavbox"> <ul class="ul analysis-list"> <li> <input type="checkbox" id="YearAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="year" />  <label for="YearAnalysis">Year Published Analysis</label> </li> <li> <input type="checkbox" id="ArticleTypeAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="at" />  <label for="ArticleTypeAnalysis">Article Type Analysis</label> </li> <li> <input type="checkbox" id="JournalTitleAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="journal" />  <label for="JournalTitleAnalysis">Publication Title Analysis</label> </li> <li> <input type="checkbox" id="CategoriesAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="subject" />  <label for="CategoriesAnalysis">Category Analysis</label> </li> </ul> <div class="refine-btn-container cl" name="analysis-check-btn-container"> <a href="javascript:ResultAnalysis();" class="refine-link-btn refine-link-btn-right" target="_self">Results Analysis</a> </div> </div> </div> <div class="refine-btn-container-n cl" id="showFacetsContainer"> <a href="javascript:InitAllFacets();" class="refine-link-btn-right" target="_self">Show more</a> </div> <div id="facetsContainer" class="cl" style="display: none;"> <div class="mnavbar" id="PubDateFacetTitle"> <div> Indexed Articles </div> </div> <div class="mnavbox" id="PubDateFacetContainer"> <ul class="ul sortedby-list"> <li> <a href="javascript:SubmitSingleFacetSearch('create','6');">Today (<span id="indexCount6"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','5');">Yesterday (<span id="indexCount5"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','4');">This Week (<span id="indexCount4"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','3');">Last Week (<span id="indexCount3"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','2');">Current Month (<span id="indexCount2"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','1');">Last Month (<span id="indexCount1"></span>)</a> </li> </ul> </div> <div id="journalFacetContainer"> <div class="mnavbar"> <div> Publication Titles </div> </div> <div class="mnavbox"> <div id="journalFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('journal');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejournalcheck" target="_self">Refine</a> </div> </div> </div> <div id="fundFacetContainer"> <div class="mnavbar"> <div> Grant Agencies </div> </div> <div class="mnavbox"> <div id="fundFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('fund');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinefundcheck" target="_self">Refine</a> </div> </div> </div> <div id="subjectFacetContainer"> <div class="mnavbar"> <div> Category </div> </div> <div class="mnavbox"> <div id="subjectFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('subject');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Li H</b>, Wu F, Han Y, Guo Z, Chen T, Ma Z. CircRNA regulates lung cancer metastasis. <em class='incite-journal-name' onclick='ShowInCiteJournal(9624);'>Gene</em> 2025;<b>935</b>:149060. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39481770' target='_blank'>39481770</a> DOI: <a href='https://dx.doi.org/10.1016/j.gene.2024.149060' target='_blank'>10.1016/j.gene.2024.149060</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.gene.2024.149060','39481770', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.gene.2024.149060' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9624);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/02/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.gene.2024.149060" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Lung cancer stands prominently among the foremost contributors to human mortality, distinguished by its elevated fatality rate and the second-highest incidence rate among malignancies. The metastatic dissemination of lung cancer stands as a primary determinant of its elevated mortality and recurrence rates, underscoring the imperative for comprehensive investigation into its metastatic pathways. Circular RNAs (circRNAs), a subclass of non-coding RNA (ncRNA) molecules, have garnered attention for their pivotal involvement in the genesis and advancement of lung cancer. Emerging evidence highlights the indispensable functions of circRNAs in orchestrating the metastatic cascade of lung cancer. This review primarily discusses the mechanisms by which circRNAs act as competitive endogenous RNAs (ceRNAs) and modulate various signaling pathways to regulate lung cancer metastasis. CircRNAs influence critical cellular processes including angiogenesis, autophagy, and glycolysis, thereby exerting influence over the metastatic cascade in lung cancer. These discoveries offer innovative perspectives and therapeutic avenues for the diagnosis and management of lung cancer. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CircRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CircRNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metastasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ceRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ceRNA</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Circular%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Circular/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Circular%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Circular/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Metastasis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Metastasis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neovascularization%2c+Pathologic%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neovascularization, Pathologic/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Gálvez-Montosa F</b>, Peduzzi G, Sanchez-Maldonado JM, Ter Horst R, Cabrera-Serrano AJ, Gentiluomo M, Macauda A, Luque N, Ünal P, García-Verdejo FJ, Li Y, López López JA, Stein A, Bueno-de-Mesquita HB, Arcidiacono PG, Zanette DL, Kahlert C, Perri F, Soucek P, Talar-Wojnarowska R, Theodoropoulos GE, Izbicki JR, Tamás H, Van Laarhoven H, Nappo G, Petrone MC, Lovecek M, Vermeulen RCH, Adamonis K, Reyes-Zurita FJ, Holleczek B, Sumskiene J, Mohelníková-Duchoňová B, Lawlor RT, Pezzilli R, Aoki MN, Pasquali C, Petrenkiene V, Basso D, Bunduc S, Comandatore A, Brenner H, Ermini S, Vanella G, Goetz MR, Archibugi L, Lucchesi M, Uzunoglu FG, Busch O, Milanetto AC, Puzzono M, Kupcinskas J, Morelli L, Sperti C, Carrara S, Capurso G, van Eijck CHJ, Oliverius M, Roth S, Tavano F, Kaaks R, Szentesi A, Vodickova L, Luchini C, Schöttker B, Landi S, Dohan O, Tacelli M, Greenhalf W, Gazouli M, Neoptolemos JP, Cavestro GM, Boggi U, Latiano A, Hegyi P, Ginocchi L, Netea MG, Sánchez-Rovira P, Canzian F, Campa D, Sainz J. Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization. <em class='incite-journal-name' onclick='ShowInCiteJournal(11478);'>Int J Cancer</em> 2025;<b>156</b>:339-352. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39319538' target='_blank'>39319538</a> DOI: <a href='https://dx.doi.org/10.1002/ijc.35196' target='_blank'>10.1002/ijc.35196</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/ijc.35196','39319538', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(2);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/ijc.35196' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11478);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/26/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1002/ijc.35196" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with patients having unresectable or metastatic disease at diagnosis, with poor prognosis and very short survival. Given that genetic variation within autophagy-related genes influences autophagic flux and susceptibility to solid cancers, we decided to investigate whether 55,583 single nucleotide polymorphisms (SNPs) within 234 autophagy-related genes could influence the risk of developing PDAC in three large independent cohorts of European ancestry including 12,754 PDAC cases and 324,926 controls. The meta-analysis of these populations identified, for the first time, the association of the BIDrs9604789 variant with an increased risk of developing the disease (ORMeta = 1.31, p = 9.67 × 10-6). We also confirmed the association of TP63rs1515496 and TP63rs35389543 variants with PDAC risk (OR = 0.89, p = 6.27 × 10-8 and OR = 1.16, p = 2.74 × 10-5). Although it is known that BID induces autophagy and TP63 promotes cell growth, cell motility and invasion, we also found that carriers of the TP63rs1515496G allele had increased numbers of FOXP3+ Helios+ T regulatory cells and CD45RA+ T regulatory cells (p = 7.67 × 10-4 and p = 1.56 × 10-3), but also decreased levels of CD4+ T regulatory cells (p = 7.86 × 10-4). These results were in agreement with research suggesting that the TP63rs1515496 variant alters binding sites for FOXA1 and CTCF, which are transcription factors involved in modulating specific subsets of regulatory T cells. In conclusion, this study identifies BID as new susceptibility locus for PDAC and confirms previous studies suggesting that the TP63 gene is involved in the development of PDAC. This study also suggests new pathogenic mechanisms of the TP63 locus in PDAC. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22functional+characterization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">functional characterization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genetic+variants%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genetic variants</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pancreatic+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pancreatic cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22polymorphisms%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">polymorphisms</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22susceptibility%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">susceptibility</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pancreatic+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pancreatic Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pancreatic+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pancreatic Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Predisposition+to+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Predisposition to Disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymorphism%2c+Single+Nucleotide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymorphism, Single Nucleotide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Suppressor+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Suppressor Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Pancreatic+Ductal%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Pancreatic Ductal/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Pancreatic+Ductal%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Pancreatic Ductal/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2c+Tumor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers, Tumor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22White+People%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">White People/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocyte+Nuclear+Factor+3-alpha%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocyte Nuclear Factor 3-alpha/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocyte+Nuclear+Factor+3-alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocyte Nuclear Factor 3-alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Case-Control+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Case-Control Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cohort+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cohort Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Forkhead+Transcription+Factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Forkhead Transcription Factors</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Czech+Republic+Ministry+of+Health%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GACR21-27902 and AZVNU21-03-00145 Czech Republic Ministry of Health</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%5c%22Casa+Sollievo+della+Sofferenza%5c%22+Hospital%2c+San+Giovanni+Rotondo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">"Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Consejer%c3%ada+de+Transformaci%c3%b3n+Econ%c3%b3mica%2c+Industria%2c+Conocimiento+y+Universidades+and+FEDER%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PY20/01282 Consejería de Transformación Económica, Industria, Conocimiento y Universidades and FEDER</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Instituto+de+Salud+Carlos+III%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PI17/02256 Instituto de Salud Carlos III</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Instituto+de+Salud+Carlos+III%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PI20/01845 Instituto de Salud Carlos III</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Associazione+Italiana+Ricerca+Cancro%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">26343 Associazione Italiana Ricerca Cancro</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Institute+for+Cancer+Research+(Programme+EXCELES)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LX22NPO5102 National Institute for Cancer Research (Programme EXCELES)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Charles+University%2c+Project+GA+UK+No.+120%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">UNCE/MED/006 Charles University, Project GA UK No. 120</a></li></ul> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Deng HW</b>, Teng WB, Zhou SD, Ye ZM, Dong ZM, Hu RT, Qin C. Long non‑coding RNA SNHG1 promotes autophagy in vascular smooth muscle cells induced by facilitating CLEC7A. <em class='incite-journal-name' onclick='ShowInCiteJournal(17029);'>Mol Med Rep</em> 2025;<b>31</b>:20. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39513586' target='_blank'>39513586</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564905' target='_blank'>PMC11564905</a> DOI: <a href='https://dx.doi.org/10.3892/mmr.2024.13385' target='_blank'>10.3892/mmr.2024.13385</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3892/mmr.2024.13385','39513586', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3892/mmr.2024.13385' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17029);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/15/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.3892/mmr.2024.13385" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Long non‑coding RNAs serve a crucial role in autophagy of vascular smooth muscle cells (VSMCs). The present study aimed to investigate the effect of small nucleolar RNA host gene 1 (SNHG1) on autophagy in VSMCs and the associated underlying mechanisms. Rapamycin was used to induce autophagy in VSMCs and the effects of SNHG1 on the proliferation and migration of VSMCs and the change in phenotype were tested following overexpression and silencing of SNHG1. The target gene of SNHG1 was predicted and validated. SNHG1‑regulated autophagy of VSMCs via C‑type lectin domain family 7 member A (CLEC7A) was determined by combined silencing of SNHG1 and overexpression of CLEC7A. Rapamycin‑induced autophagy in VSMCs changed the cell phenotype from contractile to synthetic, with decreased expression of α‑smooth muscle actin and smooth muscle protein 22a and increased expression of osteopontin. Overexpression of SNHG1 caused the same change in phenotype while the opposite change was observed following SNHG1 silencing. Overexpression of SNHG1 promoted the proliferation and migration of VSMCs. CLEC7A was identified as a target gene of SNHG1 and a direct binding relationship between them was confirmed by RNA immunoprecipitation and RNA pull‑down assays. Overexpression of SNHG1 increased the expression of CLEC7A. The expression of both SNHG1 and CLEC7A was increased during autophagy of VSMCs. Overexpression of SNHG1 promoted autophagy of VSMCs and silencing of CLEC7A reduced this effect of SNHG1. In conclusion, SNHG1 and CLEC7A were increased in VSMCs following autophagy. SNHG1 promotes the conversion of VSMCs from a contractile phenotype to a synthetic phenotype by facilitating CLEC7A expression. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22C%e2%80%91type+lectin+domain+family+7+member+A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">C‑type lectin domain family 7 member A</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22small+nucleolar+RNA+host+gene+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">small nucleolar RNA host gene 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22vascular+smooth+muscle+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">vascular smooth muscle cells</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lectins%2c+C-Type%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lectins, C-Type/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lectins%2c+C-Type%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lectins, C-Type/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle%2c+Smooth%2c+Vascular%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle, Smooth, Vascular/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle%2c+Smooth%2c+Vascular%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle, Smooth, Vascular/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocytes%2c+Smooth+Muscle%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocytes, Smooth Muscle/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Movement%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Movement/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Liu S</b>, Xu T, Chen X, Tang L, Li L, Zhang L, Yang Y, Huang J. TP53AIP1 induce autophagy via the AKT/mTOR signaling pathway in the breast cancer cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(4396);'>Cancer Biol Ther</em> 2024;<b>25</b>:2398297. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39223776' target='_blank'>39223776</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376407' target='_blank'>PMC11376407</a> DOI: <a href='https://dx.doi.org/10.1080/15384047.2024.2398297' target='_blank'>10.1080/15384047.2024.2398297</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15384047.2024.2398297','39223776', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15384047.2024.2398297' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4396);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/04/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1080/15384047.2024.2398297" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Breast cancer ranks the first in the incidence of female cancer and is the most common cancer threatening the life and health of women worldwide.Tumor protein p53-regulated apoptosis-inducing protein 1 (TP53AIP1) is a pro-apoptotic gene downstream of p53. However, the role of TP53AIP1 in BC needs to be investigated. In vitro and in vivo experiments were conducted to assess the biological functions and associated mechanisms. Several bioinformatics analyses were made, CCK8 assay, wound healing, transwell assays, colony formation assay, EDU, flow cytometry, Immunofluorescence, qRT-PCR and Western-blotting were performed. In our study, we discovered that BC samples had low levels of TP53AIP1 expression, which correlated with a lower survival rate in BC patients. When TP53AIP1 was up-regulated, it caused a decrease in cell proliferation, migration, and invasion. It also induced epithelial-to-mesenchymal transition (EMT) and protective autophagy. Furthermore, the over-expression of TP53AIP1 suppressed tumor growth when tested in vivo. We also noticed that TP53AIP1 up-regulation resulted in decreased levels of phosphorylation in AKT and mTOR, suggesting a mechanistic role. In addition, we performed functional rescue experiments where the activation of AKT was able to counteract the impact of TP53AIP1 on the survival and autophagy in breast cancer cell lines. This suggests that TP53AIP1 acts as an oncogene by controlling the AKT/mTOR pathway. These findings reveal TP53AIP1 as a gene that suppresses tumor growth and triggers autophagy through the AKT/mTOR pathway in breast cancer cells. As a result, TP53AIP1 presents itself as a potential target for novel therapeutic approaches in treating breast cancer. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TP53AIP1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TP53AIP1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22breast+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">breast cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mTOR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mTOR</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis+Regulatory+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis Regulatory Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis+Regulatory+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis Regulatory Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelial-Mesenchymal+Transition%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelial-Mesenchymal Transition/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+c-akt%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins c-akt/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Guo F</b>, Wen W, Mi Z, Long C, Shi Q, Yang M, Zhao J, Ma R. NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation. <em class='incite-journal-name' onclick='ShowInCiteJournal(4396);'>Cancer Biol Ther</em> 2024;<b>25</b>:2334463. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38569536' target='_blank'>38569536</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10993921' target='_blank'>PMC10993921</a> DOI: <a href='https://dx.doi.org/10.1080/15384047.2024.2334463' target='_blank'>10.1080/15384047.2024.2334463</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15384047.2024.2334463','38569536', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15384047.2024.2334463' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4396);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/20/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1080/15384047.2024.2334463" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was observed using TEM. NRSN2 was overexpressed in HPV-transfected LC cells. Inhibition of NRSN2 restrained the autophagy and malignant behavior of HPV-transfected LC cells. Meanwhile, the inhibition of AMPK/ULK1 pathway limited the increased autophagy of HPV-transfected LC cells caused by NRSN2 overexpression. Furthermore, NRSN2 knockdown inhibits autophagy by suppressing AMPK/ULK1 pathway, thereby restraining the malignant behavior of HPV-transfected LC cells. Our research confirmed that HPV transfection increased the autophagy and malignant behavior of LC cells by regulating the NRSN2-mediated activation of the AMPK/ULK1 pathway, offering a new target for cure of LC. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AMPK%2fULK1+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AMPK/ULK1 pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HPV%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HPV</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Laryngeal+carcinoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Laryngeal carcinoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NRSN2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NRSN2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AMP-Activated+Protein+Kinases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AMP-Activated Protein Kinases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Papillomavirus+Infections%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Papillomavirus Infections</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Protein-1+Homolog%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Protein-1 Homolog/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Protein-1+Homolog%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Protein-1 Homolog/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Zhao B</b>, Yang J, Ran F, Shi Y, Yang L, Duan Y, Shi Z, Li X, Zhang J, Li Z, Wang J. CircBIRC6 affects prostate cancer progression by regulating miR-574-5p and DNAJB1. <em class='incite-journal-name' onclick='ShowInCiteJournal(4396);'>Cancer Biol Ther</em> 2024;<b>25</b>:2399363. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39258752' target='_blank'>39258752</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404571' target='_blank'>PMC11404571</a> DOI: <a href='https://dx.doi.org/10.1080/15384047.2024.2399363' target='_blank'>10.1080/15384047.2024.2399363</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15384047.2024.2399363','39258752', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15384047.2024.2399363' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4396);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/12/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1080/15384047.2024.2399363" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Prostate cancer (PCa) is among the three main types of cancer. Although prostate-specific antigen (PSA) is routinely tested, it has disadvantages, such as poor prognostic ability. Therefore, finding more PCa markers and therapeutic targets remains a subject of study. CircRNAs have been found to have regulatory roles in various diseases, such as diabetes, Central Nervous System (CNS) neuropathy, etc. where their application in cancer is even more valuable. Therefore, this paper aims to search for differentially expressed circRNAs in PCa and find downstream targeting pathways related to autophagy. </div><div class="abstract-label">METHOD</div><div class="abstract-content">By detecting the expression of circRNA in the samples, hsa_circ_0119816 was finally identified as the research target. The properties of circRNA were verified by RNase R, actinomycin D, and fluorescence in situ hybridization (FISH). The downstream target miRNAs and target proteins were predicted by an online database, and the targeting relationship was verified using dual luciferase and RNA Immunoprecipitation. The effects of circRNAs and their downstream signalling pathways on prostate cancer cell proliferation, migration, EMT and autophagy were examined by CCK-8, Transwell, immunofluorescence and Western blotting. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">CircBIRC6 is highly expressed in prostate cancer samples. Knockdown of its expression inhibits cell proliferation, invasion, EMT and autophagy and promotes apoptosis. CircBIRC6/miRNA-574-5p/DNAJB1 is a molecular axis that regulates prostate cancer cells. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNAJB1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNAJB1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostate+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostate cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22circBIRC6%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">circBIRC6</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miRNA-574-5p%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miRNA-574-5p</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Movement%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Movement/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Progression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HSP40+Heat-Shock+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HSP40 Heat-Shock Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HSP40+Heat-Shock+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HSP40 Heat-Shock Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Circular%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Circular/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Circular%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Circular/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Chen S</b>, Lei Z, Sun T. The critical role of miRNA in bacterial zoonosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>143</b>:113267. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39374566' target='_blank'>39374566</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113267' target='_blank'>10.1016/j.intimp.2024.113267</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113267','39374566', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.113267' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.intimp.2024.113267" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The public's health and the financial sustainability of international societies remain threatened by bacterial zoonoses, with limited reliable diagnostic and therapeutic options available for bacterial diseases. Bacterial infections influence mammalian miRNA expression in host-pathogen interactions. In order to counteract bacterial infections, miRNAs participate in gene-specific expression and play important regulatory roles that rely on translational inhibition and target gene degradation by binding to the 3' non-coding region of target genes. Intriguingly, according to current studies, that exogenous miRNAs derived from plants could potentially serve as effective medicinal components sourced from traditional Chinese medicine plants. These exogenous miRNAs exhibit stable functionality in mammals and mimic the regulatory roles of endogenous miRNAs, illuminating the molecular processes behind the therapeutic effects of plants. This review details the immune defense mechanisms of inflammation, apoptosis, autophagy and cell cycle disturbance caused by some typical bacterial infections, summarizes the role of some mammalian miRNAs in regulating these mechanisms, and introduces the cGAS-STING signaling pathway in detail. Evidence suggests that this newly discovered immune defense mechanism in mammalian cells can also be affected by miRNAs. Meanwhile, some examples of transboundary regulation of mammalian mRNA and even bacterial diseases by exogenous miRNAs from plants are also summarized. This viewpoint provides fresh understanding of microbial tactics and host mechanisms in the management of bacterial illnesses. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacterial+zoonoses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacterial zoonoses</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cross-kingdom%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cross-kingdom</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+expression+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene expression regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signaling+pathways%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signaling pathways</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miRNA</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacterial+Infections%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacterial Infections/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacterial+Infections%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacterial Infections/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zoonoses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zoonoses</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Host-Pathogen+Interactions%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Host-Pathogen Interactions/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Host-Pathogen+Interactions%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Host-Pathogen Interactions/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Peng W</b>, Wang J, Du J, Xu B, Li W, Huang S. Integration of metabolomics and transcriptomics to reveal metabolic characteristics and key targets associated with lncRNA Vof-16 in H19-7 cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(3277);'>Biochem Biophys Res Commun</em> 2024;<b>736</b>:150855. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39461005' target='_blank'>39461005</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbrc.2024.150855' target='_blank'>10.1016/j.bbrc.2024.150855</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbrc.2024.150855','39461005', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbrc.2024.150855' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3277);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.bbrc.2024.150855" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cognitive disorders represent one of the most common chronic complications of diabetes. Our previous study has demonstrated that long non-coding RNA (lncRNA) Vof-16 is upregulated in the hippocampal tissue of streptozotocin (STZ)-induced diabetic rats. Despite this finding, the specific roles and underlying mechanisms of lncRNA Vof-16 in diabetes-related cognitive dysfunction remain largely unexplored. To elucidate the mechanism involved, lncRNA Vof-16 was overexpressed in rat hippocampal cell line H19-7 through lentivirus transfection. We integrated metabolomics and transcriptomics approaches to identify potential targets and metabolic pathways influenced by lncRNA Vof-16. Key proteins and pathways were subsequently validated using western blotting and immunofluorescence staining. Transcriptomics indicated that lncRNA Vof-16 overexpression may modulate autophagic activity in H19-7 cells. Metabolomic profiling revealed that the primary differential metabolic pathways included trehalose degradation, tryptophan metabolism, vitamin B6 metabolism, glycolysis, pterine biosynthesis, and the pentose phosphate pathway. Ingenuity Pathway Analysis (IPA) of gene-metabolite networks demonstrated that the high lncRNA Vof-16 expression group exhibited a significantly higher association with autophagy compared to the low lncRNA Vof-16 expression group. Western blot results confirmed that lncRNA Vof-16 overexpression led to decreased protein expression levels of ATG3 and ATG12. Specifically, lncRNA Vof-16 reduces autophagy in hippocampal neurons by targeting the elevated levels of phospho-p70S6K, a downstream effector of mTORC1, potentially contributing to the pathogenesis of diabetic cognitive impairment. The construction of gene-metabolite networks may offer promising new strategies for addressing the growing issue of diabetic cognitive impairment. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+cognitive+impairment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic cognitive impairment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcriptomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcriptomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lncRNA+Vof-16%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lncRNA Vof-16</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcriptome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcriptome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Profiling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Profiling</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Deng Q</b>, Peng Z, Meng F, Zeng W, Zhu M, Liu N, Yan W, Peng J. <i>FOXO3</i> as a potential diagnostic biomarker for autophagy in rheumatoid arthritis: A bioinformatics study. <em class='incite-journal-name' onclick='ShowInCiteJournal(3317);'>Autoimmunity</em> 2024;<b>57</b>:2423759. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39498523' target='_blank'>39498523</a> DOI: <a href='https://dx.doi.org/10.1080/08916934.2024.2423759' target='_blank'>10.1080/08916934.2024.2423759</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/08916934.2024.2423759','39498523', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/08916934.2024.2423759' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3317);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/07/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1080/08916934.2024.2423759" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study aimed to identify genes associated with autophagy and potential diagnostic biomarkers by comparing the gene expression profiles of synovial tissues in patients with rheumatoid arthritis (RA) and healthy individuals, aiming to offer new insights for clinical treatment strategies. We used publicly available datasets to analyze differentially expressed genes (DEGs) between the synovial tissue of RA patients and healthy individuals. Then, we intersected these DEGs with autophagy-related genes to identify autophagy genes in the synovial tissue of RA patients. We further analyzed the biological processes and functions of these genes. Furthermore, we used machine learning to identify characteristic autophagy genes in RA synovial tissue. Finally, we examined the differential expression of these characteristic genes in the blood of RA patients using an external dataset. Our study identified FOXO3 as a potential biomarker for diagnosing RA. FOXO3 gene expression was downregulated in both the synovial tissue and blood of RA patients, suggesting its involvement in multiple biological processes such as local inflammation, oxidative stress, metabolic processes, and immune responses. Our findings suggest that FOXO3 may be a novel biomarker for the clinical diagnosis of RA and may play a crucial role in the pathogenesis of RA. The study provides new insights into the molecular mechanisms of RA and potential new therapeutic targets. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FOXO3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FOXO3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rheumatoid+arthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rheumatoid arthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bioinformatics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bioinformatics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biomarker</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Forkhead+Box+Protein+O3%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Forkhead Box Protein O3/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Forkhead+Box+Protein+O3%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Forkhead Box Protein O3/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computational+Biology%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computational Biology/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Profiling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Profiling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Synovial+Membrane%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Synovial Membrane/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Synovial+Membrane%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Synovial Membrane/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Synovial+Membrane%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Synovial Membrane/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcriptome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcriptome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Chen YJ</b>, Knupp J, Wang E, Arvan P, Tsai B. SIGMAR1/Sigma-1 receptor: a key regulator in stabilizing and translating <i>LC3B</i> mRNA for autophagosome formation. <em class='incite-journal-name' onclick='ShowInCiteJournal(3190);'>Autophagy</em> 2024;<b>20</b>:2843-2845. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39369298' target='_blank'>39369298</a> DOI: <a href='https://dx.doi.org/10.1080/15548627.2024.2413313' target='_blank'>10.1080/15548627.2024.2413313</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15548627.2024.2413313','39369298', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15548627.2024.2413313' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3190);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/07/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1080/15548627.2024.2413313" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Macroautophagy/autophagy degrades and recycles cellular constituents via the lysosome to maintain cellular homeostasis. Our study identified the endoplasmic reticulum (ER)-resident SIGMAR1 (sigma non-opioid intracellular receptor 1) as a critical regulator of the biosynthesis of Atg8-family proteins that leads to the lipidation that is essential during autophagosome formation. We demonstrate that SIGMAR1 stabilizes MAP1LC3B/LC3B and GABARAP mRNAs, promoting their localized translation proximal to the ER for efficient lipidation. Using single-molecule fluorescence in situ hybridization/smFISH and co-immunoprecipitation, we found that SIGMAR1 directly binds to a conserved region in the 3' UTR of LC3B mRNA, facilitating its translation, efficient lipidation, and proper integration into the phagophore membrane. Cells lacking SIGMAR1 show reduced levels of many Atg8-family proteins and impaired autophagic flux. Our model suggests that SIGMAR1-mediated localized translation of Atg8-family proteins at the ER promotes efficient autophagosome formation, in contrast to recruiting preexisting cytosolic Atg8-family proteins to the lipidation machinery. Elucidating the role of SIGMAR1 in autophagy may provide better therapeutic strategies to prevent or treat autophagy-dependent neurodegenerative diseases, particularly given the highly druggable nature of SIGMAR1. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATG8%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATG8</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LC3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LC3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SIGMAR1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SIGMAR1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lipidation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lipidation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22localized+translation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">localized translation</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microtubule-Associated+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microtubule-Associated Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sigma-1+Receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sigma-1 Receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+sigma%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, sigma/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+sigma%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, sigma/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Protein+8+Family%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Protein 8 Family/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis+Regulatory+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis Regulatory Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA+Stability%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA Stability/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%223%27+Untranslated+Regions%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">3' Untranslated Regions/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Bai S</b>, Cheng H, Li H, Bo P. Integrated bioinformatics analysis identifies autophagy-associated genes as candidate biomarkers and reveals the immune infiltration landscape in psoriasis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3317);'>Autoimmunity</em> 2024;<b>57</b>:2259137. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38439147' target='_blank'>38439147</a> DOI: <a href='https://dx.doi.org/10.1080/08916934.2023.2259137' target='_blank'>10.1080/08916934.2023.2259137</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/08916934.2023.2259137','38439147', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/08916934.2023.2259137' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3317);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/01/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1080/08916934.2023.2259137" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Autophagy is implicated in the pathogenesis of psoriasis. We aimed to identify autophagy-related biomarkers in psoriasis via an integrated bioinformatics approach. We downloaded the gene expression profiles of GSE30999 dataset, and the "limma" package was applied to identify differentially expressed genes (DEGs). Then, differentially expressed autophagy-related genes (DEARGs) were identified via integrating autophagy-related genes with DEGs. CytoHubba plugin was used for the identification of hub genes and verified by the GSE41662 dataset. Subsequently, a series of bioinformatics analyses were employed, including protein-protein interaction network, functional enrichment, spearman correlation, receiver operating characteristic, and immune infiltration analyses. One hundred and one DEARGs were identified, and seven DEARGs were identified as hub genes and verified using the GSE41662 dataset. These validated genes had good diagnostic value in distinguishing psoriasis lesions. Immune infiltration analysis indicated that ATG5, SQSTM1, EGFR, MAPK8, MAPK3, MYC, and PIK3C3 were correlated with infiltration of immune cells. Seven DEARGs, namely ATG5, SQSTM1, EGFR, MAPK8, MAPK3, MYC, and PIK3C3, may be involved in the pathogenesis of psoriasis, which expanded the understanding of the development of psoriasis and provided important clinical significance for treatment of this disease. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Psoriasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Psoriasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bioinformatics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bioinformatics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hub+genes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hub genes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+infiltration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune infiltration</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sequestosome-1+Protein%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sequestosome-1 Protein</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Psoriasis%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Psoriasis/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Psoriasis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Psoriasis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computational+Biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computational Biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ErbB+Receptors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ErbB Receptors</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Liu H</b>, Xie J, Zhen C, Zeng L, Fan H, Zhuang H, Feng D. Nucleoid-phagy: a novel safeguard against mitochondrial DNA-Induced inflammation. <em class='incite-journal-name' onclick='ShowInCiteJournal(3190);'>Autophagy</em> 2024;<b>20</b>:2821-2823. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39225184' target='_blank'>39225184</a> DOI: <a href='https://dx.doi.org/10.1080/15548627.2024.2395145' target='_blank'>10.1080/15548627.2024.2395145</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15548627.2024.2395145','39225184', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15548627.2024.2395145' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3190);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/04/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1080/15548627.2024.2395145" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Mitochondria, the powerhouses of the cell, play pivotal roles in cellular processes ranging from energy production to innate immunity. Their unique double-membrane structure typically sequesters mitochondrial DNA (mtDNA) from the rest of the cell. However, under oxidative or immune stress, mtDNA can escape into the cytoplasm, posing a threat as a potential danger signal. The accumulation of cytoplasmic mtDNA can disrupt cellular immune balance and trigger cell death. Our research unveils a novel quality control mechanism, which we term "nucleoid-phagy", that safeguards cellular homeostasis by clearing mislocalized mtDNA. We demonstrate that TFAM, a key protein involved in mtDNA folding and wrapping, accompanies mtDNA into the cytoplasm under stress conditions. Remarkably, TFAM acts as an autophagy receptor, interacting with LC3B to facilitate the autophagic clearance of cytoplasmic mtDNA, thereby preventing the activation of the pro-inflammatory CGAS-STING1 pathway. This study provides unprecedented insights into cytoplasmic mtDNA quality control and offers new perspectives on mitigating inflammatory responses in mitochondrial-related diseases. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CGAS-STING1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CGAS-STING1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LIR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LIR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TFAM%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TFAM</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mitochondria+DNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mitochondria DNA</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA%2c+Mitochondrial%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA, Mitochondrial/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA%2c+Mitochondrial%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA, Mitochondrial/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondrial+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondrial Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nucleotidyltransferases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nucleotidyltransferases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nucleotidyltransferases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nucleotidyltransferases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microtubule-Associated+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microtubule-Associated Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytoplasm%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytoplasm/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Garavaglia B</b>, Nasca A, Mitola S, Ingrassia R. WDR45-dependent impairment of cell cycle in fibroblasts of patients with beta propeller protein-associated neurodegeneration (BPAN). <em>BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH</em> 2024;<b>1871</b>:119842. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39265886' target='_blank'>39265886</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbamcr.2024.119842' target='_blank'>10.1016/j.bbamcr.2024.119842</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbamcr.2024.119842','39265886', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbamcr.2024.119842' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/14/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.bbamcr.2024.119842" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">De novo mutations in the WDR45 gene have been found in patients affected by Neurodegeneration with Brain Iron Accumulation type 5 (NBIA5 or BPAN), with Non-Transferrin Bound Iron (NTBI) accumulation in the basal ganglia and WDR45-dependent impairment of autophagy. Here we show the downregulation of TFEB and cell cycle impairment in BPAN primary fibroblasts. Noteworthy, TFEB overexpression rescued this impairment, depicting a novel WDR45-dependent cell cycle phenotype. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Beta-propeller+proteinassociated+neurodegeneration+(BPAN)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Beta-propeller proteinassociated neurodegeneration (BPAN)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+cycle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell cycle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodegeneration+with+brain+iron+accumulation+(NBIA)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodegeneration with brain iron accumulation (NBIA)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TFEB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TFEB</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22WDR45%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">WDR45</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Cycle%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Cycle/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basic+Helix-Loop-Helix+Leucine+Zipper+Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basic+Helix-Loop-Helix+Leucine+Zipper+Transcription+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carrier+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carrier Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carrier+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carrier Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroaxonal+Dystrophies%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroaxonal Dystrophies/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroaxonal+Dystrophies%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroaxonal Dystrophies/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroaxonal+Dystrophies%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroaxonal Dystrophies/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Iron+Metabolism+Disorders%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Iron Metabolism Disorders</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Di Rienzo M</b>, Romagnoli A, Refolo G, Vescovo T, Ciccosanti F, Zuchegna C, Lozzi F, Occhigrossi L, Piacentini M, Fimia GM. Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases. <em class='incite-journal-name' onclick='ShowInCiteJournal(3190);'>Autophagy</em> 2024;<b>20</b>:2602-2615. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39113560' target='_blank'>39113560</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587829' target='_blank'>PMC11587829</a> DOI: <a href='https://dx.doi.org/10.1080/15548627.2024.2389474' target='_blank'>10.1080/15548627.2024.2389474</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15548627.2024.2389474','39113560', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15548627.2024.2389474' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3190);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/03/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1080/15548627.2024.2389474" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Aging is a gradual and irreversible physiological process that significantly increases the risks of developing a variety of pathologies, including neurodegenerative, cardiovascular, metabolic, musculoskeletal, and immune system diseases. Mitochondria are the energy-producing organelles, and their proper functioning is crucial for overall cellular health. Over time, mitochondrial function declines causing an increased release of harmful reactive oxygen species (ROS) and DNA, which leads to oxidative stress, inflammation and cellular damage, common features associated with various age-related pathologies. The impairment of mitophagy, the selective removal of damaged or dysfunctional mitochondria by autophagy, is relevant to the development and progression of age-related diseases. The molecular mechanisms that regulates mitophagy levels in aging remain largely uncharacterized. AMBRA1 is an intrinsically disordered scaffold protein with a unique property of regulating the activity of both proliferation and autophagy core machineries. While the role of AMBRA1 during embryonic development and neoplastic transformation has been extensively investigated, its functions in post-mitotic cells of adult tissues have been limited due to the embryonic lethality caused by AMBRA1 deficiency. Recently, a key role of AMBRA1 in selectively regulating mitophagy in post-mitotic cells has emerged. Here we summarize and discuss these results with the aim of providing a comprehensive view of the mitochondrial roles of AMBRA1, and how defective activity of AMBRA1 has been functionally linked to mitophagy alterations observed in age-related degenerative disorders, including muscular dystrophy/sarcopenia, Parkinson diseases, Alzheimer diseases and age-related macular degeneration.Abbreviations: AD: Alzheimer disease; AMD: age-related macular degeneration; AMBRA1: autophagy and beclin 1 regulator 1; APOE4: apolipoprotein E4; ATAD3A: ATPase family AAA domain containing 3A; ATG: autophagy related; BCL2: BCL2 apoptosis regulator; BH3: BCL2-homology-3; BNIP3L/NIX: BCL2 interacting protein 3 like; CDK: cyclin dependent kinase; CHUK/IKKα: component of inhibitor of nuclear factor kappa B kinase complex; CRL2: CUL2-RING ubiquitin ligase; DDB1: damage specific DNA binding protein 1; ER: endoplasmic reticulum; FOXO: forkhead box O; FUNDC1: FUN14 domain containing 1; GBA/β-glucocerebrosidase: glucosylceramidase beta; HUWE1: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1; IDR: intrinsically disordered region; LIR: LC3-interacting region; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAVS: mitochondrial antiviral signaling protein; MCL1: MCL1 apoptosis regulator, BCL2 family member; MFN2: mitofusin 2; MTOR: mechanistic target of rapamycin kinase; MSA: multiple system atrophy; MYC: MYC proto-oncogene, bHLH transcription factor; NUMA1: nuclear mitotic apparatus protein 1; OMM; mitochondria outer membrane; PD: Parkinson disease; PHB2: prohibitin 2; PINK1: PTEN induced kinase 1; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PTK2/FAK: protein tyrosine kinase 2; ROS: reactive oxygen species; RPE: retinal pigment epithelium; SAD: sporadic AD; SOCS3: suppressor of cytokine signaling 3; SRC, SRC proto-oncogene, non-receptor tyrosine kinase; STAT3: signal transducer and activator of transcription 3; STING1: stimulator of interferon response cGAMP interactor 1; SQSTM1/p62: sequestosome 1; TBK1: TANK binding kinase 1; TGFB/TGFβ: transforming growth factor beta; TOMM: translocase of outer mitochondrial membrane; TRAF6: TNF receptor associated factor 6; TRIM32: tripartite motif containing 32; ULK1: unc-51 like autophagy activating kinase 1. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AMBRA1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AMBRA1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22aging-related+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">aging-related diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mitochondria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mitochondria</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mitophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mitophagy</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitophagy%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitophagy/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aging%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aging/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Ren J</b>, Chen X, Li J, Zan Y, Wang S, Tan Y, Ding Y. TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy. <em class='incite-journal-name' onclick='ShowInCiteJournal(8558);'>Epigenetics</em> 2024;<b>19</b>:2323751. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38431880' target='_blank'>38431880</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10913696' target='_blank'>PMC10913696</a> DOI: <a href='https://dx.doi.org/10.1080/15592294.2024.2323751' target='_blank'>10.1080/15592294.2024.2323751</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15592294.2024.2323751','38431880', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15592294.2024.2323751' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8558);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1080/15592294.2024.2323751" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Methylation modifications play pertinent roles in regulating gene expression and various biological processes. The silencing of the demethylase enzyme TET1 can affect the expressions of key oncogenes or tumour suppressor genes, thus contributing to tumour formation. Nonetheless, how TET1 affects the progression of cervical cancer is yet to be elucidated. In this study, we found that the expression of TET1 was significantly downregulated in cervical cancer tissues. Functionally, TET1 knockdown in cervical cancer cells can promote cell proliferation, migration, invasion, cervical xenograft tumour formation and EMT. On the contrary, its overexpression can reverse the aforementioned processes. Moreover, the autophagy level of cervical cancer cells can be enhanced after TET1 knockdown. Mechanistically, methylated DNA immunoprecipitation (MeDIP)-sequencing and MeDIP quantitative real-time PCR revealed that TET1 mediates the methylation of autophagy promoter regions. These findings suggest that TET1 affects the autophagy of cervical cancer cells by altering the methylation levels of NKRF or HIST1H2AK, but the specific mechanism needs to be investigated further. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cervical+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cervical cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22EMT%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">EMT</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TET1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TET1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+Methylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA Methylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mixed+Function+Oxygenases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mixed Function Oxygenases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Processing%2c+Post-Translational%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Processing, Post-Translational</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uterine+Cervical+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uterine Cervical Neoplasms/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>He X</b>, Zhao X, Wang H. LPI-GPR55 promotes endothelial cell activation and inhibits autophagy through inducing LINC01235 expression. <em class='incite-journal-name' onclick='ShowInCiteJournal(2141);'>Ann Med</em> 2024;<b>56</b>:2407525. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39316662' target='_blank'>39316662</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423533' target='_blank'>PMC11423533</a> DOI: <a href='https://dx.doi.org/10.1080/07853890.2024.2407525' target='_blank'>10.1080/07853890.2024.2407525</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/07853890.2024.2407525','39316662', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/07853890.2024.2407525' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(2141);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rp.tandfonline.com/submission/login' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/26/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1080/07853890.2024.2407525" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">INTRODUCTION</div><div class="abstract-content">Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid accumulation, inflammation and apoptosis of the arterial wall. This study evaluated the effects of lysophosphatidylinositol (LPI) on endothelial cells activation and autophagy in AS. </div><div class="abstract-label">METHODS</div><div class="abstract-content">qRT-PCR and Western blotting were done to verify the expression of ICAM1, GPR55 and SOD2. RNA-Seq was performed and screened for the different expressions of long noncoding RNAs (lncRNAs), combining bioinformatics analysis to elucidate the mechanism by which lncRNA functions. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">qRT-PCR and Western blotting results showed that LPI increased GPR55 and ICAM1 expression. RNA-Seq analysis and qRT-PCR results showed that LPI increased the expression of LINC01235, LINC00520 and LINC01963; LINC01235 was the most obvious. Mechanistically, bioinformatic analysis demonstrated that LINC01235 inhibited autophagy through sponging miR-224-3p. And miRNA-224-3p targeted RABEP1. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">LPI promoted endothelial cell activation. LPI induced the expression of LINC01235 and LINC01235 inhibited autophagy through miR-224-3p/RABEP1. Collectively, this study first reveals the function of LINC01235, which may serve as a potential therapeutic target in AS. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LINC01235%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LINC01235</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lysophosphatidylinositol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lysophosphatidylinositol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RABEP1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RABEP1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miRNA-224-3p%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miRNA-224-3p</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Cannabinoid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Cannabinoid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Cannabinoid%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Cannabinoid/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lysophospholipids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lysophospholipids/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lysophospholipids%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lysophospholipids/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endothelial+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endothelial Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intercellular+Adhesion+Molecule-1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intercellular Adhesion Molecule-1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intercellular+Adhesion+Molecule-1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intercellular Adhesion Molecule-1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Human+Umbilical+Vein+Endothelial+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Human Umbilical Vein Endothelial Cells/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Goh KY</b>, Lee WX, Choy SM, Priyadarshini GK, Chua K, Tan QH, Low SY, Chin HS, Wong CS, Huang SY, Fu NY, Nishiyama J, Harmston N, Tang HW. FOXO-regulated DEAF1 controls muscle regeneration through autophagy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3190);'>Autophagy</em> 2024;<b>20</b>:2632-2654. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38963021' target='_blank'>38963021</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587838' target='_blank'>PMC11587838</a> DOI: <a href='https://dx.doi.org/10.1080/15548627.2024.2374693' target='_blank'>10.1080/15548627.2024.2374693</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15548627.2024.2374693','38963021', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15548627.2024.2374693' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3190);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1080/15548627.2024.2374693" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The commonality between various muscle diseases is the loss of muscle mass, function, and regeneration, which severely restricts mobility and impairs the quality of life. With muscle stem cells (MuSCs) playing a key role in facilitating muscle repair, targeting regulators of muscle regeneration has been shown to be a promising therapeutic approach to repair muscles. However, the underlying molecular mechanisms driving muscle regeneration are complex and poorly understood. Here, we identified a new regulator of muscle regeneration, Deaf1 (Deformed epidermal autoregulatory factor-1) - a transcriptional factor downstream of foxo signaling. We showed that Deaf1 is transcriptionally repressed by FOXOs and that DEAF1 targets to Pik3c3 and Atg16l1 promoter regions and suppresses their expression. Deaf1 depletion therefore induces macroautophagy/autophagy, which in turn blocks MuSC survival and differentiation. In contrast, Deaf1 overexpression inactivates autophagy in MuSCs, leading to increased protein aggregation and cell death. The fact that Deaf1 depletion and its overexpression both lead to defects in muscle regeneration highlights the importance of fine tuning DEAF1-regulated autophagy during muscle regeneration. We further showed that Deaf1 expression is altered in aging and cachectic MuSCs. Manipulation of Deaf1 expression can attenuate muscle atrophy and restore muscle regeneration in aged mice or mice with cachectic cancers. Together, our findings unveil an evolutionarily conserved role for DEAF1 in muscle regeneration, providing insights into the development of new therapeutic strategies against muscle atrophy.Abbreviations: DEAF1: Deformed epidermal autoregulatory factor-1; FOXO: Forkhead box O; MuSC: Muscle Stem Cell; PAX7: Paired box 7; PIK3C3: Phosphatidylinositol 3-kinase catalytic subunit type 3. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Deaf1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Deaf1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FOXO%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FOXO</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer+cachexia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer cachexia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22muscle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">muscle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sarcopenia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sarcopenia</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Regeneration%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Regeneration/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle%2c+Skeletal%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle, Skeletal/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA-Binding+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA-Binding Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Forkhead+Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Forkhead Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Forkhead+Transcription+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Forkhead Transcription Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Kumar A</b>, Singh MK, Singh V, Shrivastava A, Sahu DK, Bisht D, Singh S. The role of autophagy dysregulation in low and high-grade nonmuscle invasive bladder cancer: A survival analysis and clinicopathological association. <em class='incite-journal-name' onclick='ShowInCiteJournal(169013);'>Urol Oncol</em> 2024;<b>42</b>:452.e1-452.e13. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39256148' target='_blank'>39256148</a> DOI: <a href='https://dx.doi.org/10.1016/j.urolonc.2024.07.017' target='_blank'>10.1016/j.urolonc.2024.07.017</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.urolonc.2024.07.017','39256148', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.urolonc.2024.07.017' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169013);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/12/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.urolonc.2024.07.017" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">INTRODUCTION</div><div class="abstract-content">Bladder cancer disproportionately affects men and often presents as nonmuscle-invasive bladder cancer (NMIBC). Despite initial treatments, the recurrence and progression of NMIBC are linked to autophagy. This study investigates the expression of autophagy genes (mTOR, ULK1, Beclin1, and LC3) in low and high-grade NMIBC, providing insights into potential prognostic markers and therapeutic targets. </div><div class="abstract-label">MATERIAL AND METHODS</div><div class="abstract-content">A total of 115 tissue samples (n = 85 NMIBC (pTa, pT1, and CIS) and n = 30 control from BPH patients) were collected. The expression level of autophagy genes (mTOR, ULK1, Beclin1, and LC3) and their proteins were assessed in low and high-grade NMIBC, along with control tissue samples using quantitative real-time polymerase chain reaction and western blotting. Association with clinicopathological characteristics and autophagy gene expression was analyzed by multivariate and univariate survival analysis using SPSS. </div><div class="abstract-label">RESULT</div><div class="abstract-content">In high-grade NMIBC, ULK1, P = 0.0150, Beclin1, P = 0.0041, and LC3, P = 0.0014, were substantially downregulated, whereas mTOR, P = 0.0006, was significantly upregulated. The KM plots show significant survival outcomes with autophagy genes. The clinicopathological characters, high grade (P = 0.019), tumor stage (CIS P = 0.039, pT1 P = 0.018, P = 0.045), male (P = 0.010), lymphovascular invasion (P = 0.028) and autophagy genes (ULK1 P = 0.002, beclin1 (P = 0.010, P = 0.022) were associated as risk factors for survival outcome in NMIBC patients. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The upregulated mTOR, downregulated ULK1, and beclin1 expression is linked to a high-grade, CIS and pT1 stage, resulting in poor recurrence-free survival and progression-free survival and highlights the prognostic significance of autophagy gene in nonmuscle-invasive bladder cancer. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NMIBC%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NMIBC</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prognostic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prognostic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Survival+outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Survival outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22low+and+high+grade%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">low and high grade</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Urinary+Bladder+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Urinary Bladder Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Urinary+Bladder+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Urinary Bladder Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Urinary+Bladder+Neoplasms%2fmortality%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Urinary Bladder Neoplasms/mortality</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Urinary+Bladder+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Urinary Bladder Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Grading%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Grading</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Survival+Analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Survival Analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Invasiveness%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Invasiveness</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Protein-1+Homolog%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Protein-1 Homolog/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Protein-1+Homolog%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Protein-1 Homolog/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prognosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Sakhi IB</b>, De Combiens E, Frachon N, Durussel F, Brideau G, Nemazanyy I, Frère P, Thévenod F, Lee WK, Zeng Q, Klein C, Lourdel S, Bignon Y. A novel transgenic mouse model highlights molecular disruptions involved in the pathogenesis of Dent disease 1. <em class='incite-journal-name' onclick='ShowInCiteJournal(9624);'>Gene</em> 2024;<b>928</b>:148766. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39019097' target='_blank'>39019097</a> DOI: <a href='https://dx.doi.org/10.1016/j.gene.2024.148766' target='_blank'>10.1016/j.gene.2024.148766</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.gene.2024.148766','39019097', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.gene.2024.148766' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9624);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1016/j.gene.2024.148766" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Dent disease (DD) is a hereditary renal disorder characterized by low molecular weight (LMW) proteinuria and progressive renal failure. Inactivating mutations of the CLCN5 gene encoding the 2Cl-/H+exchanger ClC-5 have been identified in patients with DD type 1. ClC-5 is essentially expressed in proximal tubules (PT) where it is thought to play a role in maintaining an efficient endocytosis of LMW proteins. However, the exact pathological roles of ClC-5 in progressive dysfunctions observed in DD type 1 are still unclear. To address this issue, we designed a mouse model carrying the most representative type of ClC-5 missense mutations found in DD patients. These mice showed a characteristic DD type 1 phenotype accompanied by altered endo-lysosomal system and autophagy functions. With ageing, KI mice showed increased renal fibrosis, apoptosis and major changes in cell metabolic functions as already suggested in previous DD models. Furthermore, we made the interesting new discovery that the Lipocalin-2-24p3R pathway might be involved in the progression of the disease. These results suggest a crosstalk between the proximal and distal nephron in the pathogenesis mechanisms involved in DD with an initial PT impairment followed by the Lipocalin-2 internalisation and 24p3R overexpression in more distal segments of the nephron. This first animal model of DD carrying a pathogenic mutation of Clcn5 and our findings pave the way aimed at exploring therapeutic strategies to limit the consequences of ClC-5 disruption in patients with DD type 1 developing chronic kidney disease. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ClC-5%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ClC-5</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dent+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dent disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endocytosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endocytosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipcalin-2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipcalin-2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proximal+tubule%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proximal tubule</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+damage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue damage</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chloride+Channels%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chloride Channels/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chloride+Channels%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chloride Channels/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Transgenic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Transgenic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dent+Disease%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dent Disease/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Tubules%2c+Proximal%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Tubules, Proximal/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Tubules%2c+Proximal%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Tubules, Proximal/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%2c+Missense%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation, Missense</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipocalin-2%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipocalin-2/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipocalin-2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipocalin-2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Diseases%2c+X-Linked%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Diseases, X-Linked</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nephrolithiasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nephrolithiasis</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Huang T</b>, Su C, Su Q, Nie Y, Xiao Z, Tang Y, Wang J, Luo X, Tang Y. Identification and validation of three diagnostic autophagy-related genes associated with advanced plaques and immune cell infiltration in carotid atherosclerosis based on integrated bioinformatics analyses. <em class='incite-journal-name' onclick='ShowInCiteJournal(18900);'>PeerJ</em> 2024;<b>12</b>:e18543. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39588003' target='_blank'>39588003</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587871' target='_blank'>PMC11587871</a> DOI: <a href='https://dx.doi.org/10.7717/peerj.18543' target='_blank'>10.7717/peerj.18543</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.7717/peerj.18543','39588003', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.7717/peerj.18543' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/15c747d169de91760cd3d2dc6088e534/peerj-12-18543.PMC11587871.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.7717/peerj.18543');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18900);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/27/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.7717/peerj.18543" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">Autophagy plays a key role in the development of carotid atherosclerosis (CAS). This study aimed to identify key autophagy-related genes (ATGs) related with CAS using bioinformatics analysis, in vivo AS mouse model, and in vitro experiments. </div><div class="abstract-label">Methods</div><div class="abstract-content">The GSE100927 and GSE28829 datasets were downloaded from the Gene Expression Omnibus (GEO) database. An integrated bioinformatics analyses of differentially expressed ATGs (DE-ATGs) was conducted. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to identify the biological processes and pathways associated with DE-ATGs. Protein-protein interaction (PPI) network was constructed with the DE-ATGs to identify the key CAS-related DE-ATGs. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic value of the key CAS-related DE-ATGs. CIBERSORT analysis was performed to determine the infiltration status of 22 immune cell types and their correlation with the expression levels of the key CAS-related DE-ATGs. Hematoxylin and eosin (HE) staining was used to estimate the plaque histology in the AS mouse model. Western blotting, quantitative real-time PCR (qRT-PCR), and immunohistochemistry (IHC) were performed to validate the protein and mRNA expression levels of the key CAS-related DE-ATGs in the in vitro and in vivo models. </div><div class="abstract-label">Results</div><div class="abstract-content">We compared transcriptome profiles of 12 early CAS plaques and 29 advanced CAS plaques in the GSE100927 dataset and identified 41 DE-ATGs (33 up-regulated and eight down-regulated). Functional enrichment analysis showed that the DE-ATGs were closely related with apoptosis, autophagy, and immune activation. ROC curve analysis showed that the area under the curve (AUC) values for the three key CAS-related DE-ATGs (CCL2, LAMP2, and CTSB) were 0.707, 0.977, and 0.951, respectively. CIBERSORT analyses showed close association between the three key CAS-related DE-ATGs and the infiltration of immune cell types in the plaques. Finally, the western blot, qRT-PCR, and IHC staining confirmed that CCL2, LAMP2, and CTSB were highly expressed in the plaques of the AS model mice or ox-LDL-treated human umbilical vein endothelial cells (HUVECs) and human aorta vascular smooth muscle cells (HAoSMCs). </div><div class="abstract-label">Conclusion</div><div class="abstract-content">We identified and validated three key CAS-associated ATGs, namely, CCL2, LAMP2, and CTSB with high diagnostic value. These three key CAS-associated ATGs are promising diagnostic markers and therapeutic targets for patients with CAS. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bioinformatics+analyses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bioinformatics analyses</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carotid+atherosclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carotid atherosclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+cell+infiltration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune cell infiltration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunohistochemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunohistochemistry</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carotid+Artery+Diseases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carotid Artery Diseases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carotid+Artery+Diseases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carotid Artery Diseases/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carotid+Artery+Diseases%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carotid Artery Diseases/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computational+Biology%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computational Biology/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plaque%2c+Atherosclerotic%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plaque, Atherosclerotic/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plaque%2c+Atherosclerotic%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plaque, Atherosclerotic/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plaque%2c+Atherosclerotic%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plaque, Atherosclerotic/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Interaction+Maps%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Interaction Maps/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Yan H</b>, Lu Z, Du X, You Z, Yang M, Li N, Li X, Ni Z, Wu H, Wang X, Zhao L, Wang H. Autophagy modulates Arabidopsis male gametophyte fertility and controls actin organization. <em class='incite-journal-name' onclick='ShowInCiteJournal(17180);'>Nat Commun</em> 2024;<b>15</b>:10071. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39567510' target='_blank'>39567510</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579482' target='_blank'>PMC11579482</a> DOI: <a href='https://dx.doi.org/10.1038/s41467-024-54468-8' target='_blank'>10.1038/s41467-024-54468-8</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41467-024-54468-8','39567510', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(21);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41467-024-54468-8' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17180);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/22/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1038/s41467-024-54468-8" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Autophagy, a crucial mechanism for cellular degradation, is regulated by conserved autophagy-related (ATG) core proteins across species. Impairments in autophagy result in significant developmental and reproductive aberrations in mammals. However, autophagy is thought to be functionally dispensable in Arabidopsis thaliana since most of the ATG mutants lack severe growth and reproductive defects. Here, we challenge this perception by unveiling a role for autophagy in male gametophyte development and fertility in Arabidopsis. A detailed re-assessment of atg5 and atg7 mutants found that reduced autophagy activity in germinated pollen accompanied by partial aberrations in sperm cell biogenesis and pollen tube growth, leading to compromised seed formation. Furthermore, we revealed autophagy modulates the spatial organization of actin filaments via targeted degradation of actin depolymerization factors ADF7 and Profilin2 in pollen grains and tubes through a key receptor, Neighbor of BRCA1 (NBR1). Our findings advance the understanding of the evolutionary conservation and diversification of autophagy in modulating male fertility in plants contrasting to mammals. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pollen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pollen</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22macroautophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">macroautophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22plant+cell+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">plant cell biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22plant+development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">plant development</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arabidopsis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arabidopsis/genetics</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22China+Postdoctoral+Science+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2022M721204 China Postdoctoral Science Foundation</a></li></ul> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Xing ZY</b>, Liu W, Xing RJ, Chen JF, Xiong J. Integrated analysis ceRNA network of autophagy-related gene RNF144B in steroid-induced necrosis of the femoral head. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2024;<b>14</b>:28737. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39567703' target='_blank'>39567703</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579326' target='_blank'>PMC11579326</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-024-79923-w' target='_blank'>10.1038/s41598-024-79923-w</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-024-79923-w','39567703', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-024-79923-w' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/22/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1038/s41598-024-79923-w" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study aimed to investigate the regulatory mechanisms that influenced autophagy in Steroid-induced necrosis of the femoral head (SONFH) by constructing a competing endogenous RNA (ceRNA) network. Blood sample data from the SONFH patients were obtained from the Gene Expression Omnibus (GEO) database under the accession number GSE123568. Autophagy-related genes were identified from the Human Autophagy Database (HADb). Differential analysis and weighted gene co-expression network analysis (WGCNA) were performed on the GSE123568 dataset to screen for core genes and validation was performed with the validation set. Based on the GEO dataset (GSE74089), we performed differential lncRNA analysis. Meanwhile, we utilized three databases, namely miRDB, TargetScan, and StarBase, to predict the miRNAs of target genes and corresponding lncRNAs. Cytoscape software was used to construct and visualize the ceRNA networks. We also employed reverse transcription-quantitative polymerase chain reaction (RT-qPCR) to quantify their expression levels. A total of 1692 differentially expressed genes (DEGs) were identified in the GSE123568 dataset. By intersecting with the HADb database, 47 autophagy-related genes were identified from these DEGs. Furthermore, we found the significant correlation between RNF144B and 37 autophagy genes. Importantly, we established a regulatory axis involving TUG1, hsa-miR-31-5p, and RNF144B., and both TUG1 and RNF144B were upregulated, while hsa-miR-31-5p was downregulated in the SONFH cell model. A TUG1-hsa-miR-31-5p-RNF144B axis was related to autophagy genes, which potentially provided insights into the RNA interactions triggering autophagy in SONFH. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CeRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CeRNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNF144B%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNF144B</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Steroid-induced+osteonecrosis+of+the+femoral+head%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Steroid-induced osteonecrosis of the femoral head</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Regulatory+Networks%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Regulatory Networks</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Femur+Head+Necrosis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Femur Head Necrosis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Femur+Head+Necrosis%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Femur Head Necrosis/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Femur+Head+Necrosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Femur Head Necrosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Profiling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Profiling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Steroids%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Steroids</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Competitive+Endogenous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Competitive Endogenous</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Li Y</b>, Sun Y, Jia B, Ma Z, Zhou R. MED23 depletion induces premature senescence in NSCLC cells by interacting with BCLAF1 and then suppressing NUPR1 expression. <em class='incite-journal-name' onclick='ShowInCiteJournal(3277);'>Biochem Biophys Res Commun</em> 2024;<b>734</b>:150754. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366174' target='_blank'>39366174</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbrc.2024.150754' target='_blank'>10.1016/j.bbrc.2024.150754</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbrc.2024.150754','39366174', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbrc.2024.150754' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3277);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.bbrc.2024.150754" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Lung cancer is the leading cause of cancer death worldwide. 85 % of lung cancers are categorized by their histological types as a non-small cell lung cancer (NSCLC) subtype. While the MED23 subunit of the mediator complex has been implicated in lung cancer development, the precise underlying mechanism remains unclear. Our research indicates that elevated MED23 expression is linked to reduced overall survival rates in NSCLC. Depletion of MED23 triggers premature senescence in NSCLC cells. Furthermore, through co-IP and mass spectrometry analyses, we have identified BCLAF1 as a binding partner of MED23, with subsequent confirmation via PLA assays. Subsequently, NUPR1, a transcriptional cofactor known to induce premature senescence in lung cancer cells by disrupting autophagic processes, was validated as a downstream target of the MED23/BCLAF1 complex through RNA-seq and ChIP assays. Thus, the interaction between MED23 and BCLAF1 regulates NUPR1 expression, impacting autophagic flux and leading to premature senescence in NSCLC cells. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22BCLAF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">BCLAF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MED23%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MED23</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NSCLC%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NSCLC</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NUPR1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NUPR1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Premature+senescence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Premature senescence</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Non-Small-Cell+Lung%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Non-Small-Cell Lung/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Non-Small-Cell+Lung%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Non-Small-Cell Lung/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Non-Small-Cell+Lung%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Non-Small-Cell Lung/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basic+Helix-Loop-Helix+Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Basic Helix-Loop-Helix Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basic+Helix-Loop-Helix+Transcription+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Basic Helix-Loop-Helix Transcription Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellular+Senescence%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellular Senescence/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Repressor+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Repressor Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Repressor+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Repressor Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mediator+Complex%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mediator Complex/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mediator+Complex%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mediator Complex/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Binding%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Binding</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Suppressor+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Suppressor Proteins</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Bai Y</b>, Tang Q, Zheng L, He J, Wang W, Li L, Yu J. Elevated expression of APOO as a potential prognostic marker in breast cancer: insights from bioinformatic analysis and experimental validation. <em class='incite-journal-name' onclick='ShowInCiteJournal(4081);'>BMC Med Genomics</em> 2024;<b>17</b>:271. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39558346' target='_blank'>39558346</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572147' target='_blank'>PMC11572147</a> DOI: <a href='https://dx.doi.org/10.1186/s12920-024-02047-7' target='_blank'>10.1186/s12920-024-02047-7</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s12920-024-02047-7','39558346', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s12920-024-02047-7' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4081);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/20/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1186/s12920-024-02047-7" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Apolipoprotein O (APOO) has been identified through bioinformatic prediction analysis as being highly expressed in various tumors, including breast cancer (BRCA). However, further investigations are required to understand and confirm APOO's biological role in BRCA. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Bioinformatic analyses were employed to identify genes' expression statuses and their relationship with the prognoses of patients. The genes' functions were determined in cell line by gain or loss of function assays. Mechanistic studies were carried out by western blot. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Our study reveals a correlation between increased APOO expression and poorer clinical outcomes in BRCA patients. The diagnostic value of APOO was demonstrated by Receiver Operating Characteristic (ROC) curve analysis, showing a notable area under the curve (AUC) of 0.937. Additionally, we observed that APOO knockdown impedes cell proliferation and migration. Gene Set Enrichment Analysis (GSEA) suggests that APOO expression is associated with the regulation of apoptosis and autophagy signaling pathways. Experimentally, modifying APOO expression in vitro influenced apoptosis and autophagy in BRCA cells. In conclusion, our findings indicate a significant link between APOO expression and BRCA progression, mediated through APOO's impact on cellular apoptosis and autophagy. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Our data show that APOO controls BRCA process through apoptosis and autophagy signal pathway, which might provide multiple promising choices for the treatment of BRCA. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apolipoprotein%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apolipoprotein</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast cancer</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computational+Biology%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computational Biology/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prognosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2c+Tumor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers, Tumor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2c+Tumor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers, Tumor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Movement%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Movement</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82203292 National Natural Science Foundation of China</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Labrador L</b>, Rodriguez L, Beltran S, Hernandez F, Gomez L, Ojeda P, Bergmann C, Calegaro-Nassif M, Kerr B, Medinas DB, Manque P, Woehlbier U. Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1<sup>G93A</sup> ALS mouse model. <em class='incite-journal-name' onclick='ShowInCiteJournal(3521);'>Biol Res</em> 2024;<b>57</b>:86. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39551782' target='_blank'>39551782</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571584' target='_blank'>PMC11571584</a> DOI: <a href='https://dx.doi.org/10.1186/s40659-024-00567-1' target='_blank'>10.1186/s40659-024-00567-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s40659-024-00567-1','39551782', 'Autophagy/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(25);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s40659-024-00567-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3521);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/19/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1186/s40659-024-00567-1" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal paralytic disorder associated with motor neuron death. Mutant superoxide dismutase 1 (SOD1) misfolding and aggregation have been linked to familial ALS, with the accumulation of abnormal wild-type SOD1 species being also observed in postmortem tissue of sporadic ALS cases. Both wild-type and mutated SOD1 are reported to contribute to motoneuron cell death. The autophagic pathway has been shown to be dysregulated in ALS. Recent evidence suggests a dual time-dependent role of autophagy in the progression of the disease. PACER, also called RUBCNL (Rubicon-like), is an enhancer of autophagy and has been found diminished in its levels during ALS pathology in mice and humans. Pacer loss of function disturbs the autophagy process and leads to the accumulation of SOD1 aggregates, as well as sensitizes neurons to death. Therefore, here we investigated if constitutive overexpression of PACER in neurons since early development is beneficial in an in vivo model of ALS. We generated a transgenic mouse model overexpressing human PACER in neurons, which then was crossbred with the mutant SOD1G93A ALS mouse model. Unexpectedly, PACER/SOD1G93A double transgenic mice exhibited an earlier disease onset and shorter lifespan than did littermate SOD1G93A mice. The overexpression of PACER in neurons in vivo and in vitro increased the accumulation of SOD1 aggregates, possibly due to impaired autophagy. These results suggest that similar to Pacer loss-of function, Pacer gain-of function is detrimental to autophagy, increases SOD1 aggregation and worsens ALS pathogenesis. In a wider context, our results indicate the requirement to maintain a fine balance of PACER protein levels to sustain proteostasis. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amyotrophic+lateral+sclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amyotrophic lateral sclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22KIAA0226L%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">KIAA0226L</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PACER%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PACER</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RUBCNL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RUBCNL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SQSTM1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SQSTM1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Superoxide+dismutase+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Agencia+Nacional+de+Investigaci%c3%b3n+y+Desarrollo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ACT210039 Agencia Nacional de Investigación y Desarrollo</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Agencia+Nacional+de+Investigaci%c3%b3n+y+Desarrollo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">11240328 Agencia Nacional de Investigación y Desarrollo</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Agencia+Nacional+de+Investigaci%c3%b3n+y+Desarrollo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">1240176 Agencia Nacional de Investigación y Desarrollo</a></li></ul> <a href="javascript:ShowArticleGrant(25);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> 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</div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Autophagy/genetics (2780 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Autophagy/genetics (2780 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>