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Evolution"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"The fate of competing beneficial mutations in an asexual population","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [50566687]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" 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population</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="50566687" href="https://independent.academia.edu/PGerrish"><img alt="Profile image of Philip Gerrish" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/50566687/85182488/73826610/s65_philip.gerrish.png" />Philip Gerrish</a></div><p class="ds-work-card--detail ds2-5-body-sm">1998, Mutation and Evolution</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":82407929,"attachmentType":"pdf","workUrl":"https://www.academia.edu/74156548/The_fate_of_competing_beneficial_mutations_in_an_asexual_population"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" 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data-collection-position="0" data-entity-id="74156533" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74156533/Beneficial_mutations_and_the_dynamics_of_adaptation_in_asexual_populations">Beneficial mutations and the dynamics of adaptation in asexual populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50566687" href="https://independent.academia.edu/PGerrish">Philip Gerrish</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Philosophical Transactions of the Royal Society B: Biological Sciences, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">We discuss the dynamics of adaptive evolution in asexual (clonal) populations. The classical ‘periodic selection’ model of clonal evolution assumed that beneficial mutations are very rare and therefore substitute unfettered into populations as occasional, isolated events. Newer models allow for the possibility that beneficial mutations are sufficiently common to coexist and compete for fixation within populations. Experimental evolution studies in microbes provide empirical support for stochastic models in which both selection and mutation are strong effects and clones compete for fixation; however, the relative importance of competition among clones bearing mutations of different selective effects versus competition among clones bearing multiple mutations remains unresolved. We provide some new theoretical results, moreover, suggesting that population dynamics consistent with the periodic selection model can arise even in a deterministic model that can accommodate a very high benef...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Beneficial mutations and the dynamics of adaptation in asexual populations","attachmentId":83655782,"attachmentType":"pdf","work_url":"https://www.academia.edu/74156533/Beneficial_mutations_and_the_dynamics_of_adaptation_in_asexual_populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74156533/Beneficial_mutations_and_the_dynamics_of_adaptation_in_asexual_populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="17478895" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17478895/Diminishing_Returns_from_Mutation_Supply_Rate_in_Asexual_Populations">Diminishing Returns from Mutation Supply Rate in Asexual Populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37236119" href="https://independent.academia.edu/BlanchardJeffrey">Jeffrey Blanchard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Science, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Diminishing Returns from Mutation Supply Rate in Asexual Populations","attachmentId":39533030,"attachmentType":"pdf","work_url":"https://www.academia.edu/17478895/Diminishing_Returns_from_Mutation_Supply_Rate_in_Asexual_Populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17478895/Diminishing_Returns_from_Mutation_Supply_Rate_in_Asexual_Populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="74728995" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74728995/Distribution_of_fixed_beneficial_mutations_and_the_rate_of_adaptation_in_asexual_populations">Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="194511207" href="https://independent.academia.edu/IgorRouzine">Igor Rouzine</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Proceedings of the National Academy of Sciences, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">When large asexual populations adapt, competition between simultaneously segregating mutations slows the rate of adaptation and restricts the set of mutations that eventually fix. This phenomenon of interference arises from competition between mutations of different strengths as well as competition between mutations that arise on different fitness backgrounds. Previous work has explored each of these effects in isolation, but the way they combine to influence the dynamics of adaptation remains largely unknown. Here, we describe a theoretical model to treat both aspects of interference in large populations. We calculate the rate of adaptation and the distribution of fixed mutational effects accumulated by the population. We focus particular attention on the case when the effects of beneficial mutations are exponentially distributed, as well as on a more general class of exponential-like distributions. In both cases, we show that the rate of adaptation and the influence of genetic bac...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations","attachmentId":82774193,"attachmentType":"pdf","work_url":"https://www.academia.edu/74728995/Distribution_of_fixed_beneficial_mutations_and_the_rate_of_adaptation_in_asexual_populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74728995/Distribution_of_fixed_beneficial_mutations_and_the_rate_of_adaptation_in_asexual_populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="31625249" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31625249/The_Fixation_Probability_of_Rare_Mutators_in_Finite_Asexual_Populations">The Fixation Probability of Rare Mutators in Finite Asexual Populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32605520" href="https://independent.academia.edu/DavidKessler3">David S Kessler</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Genetics, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Fixation Probability of Rare Mutators in Finite Asexual Populations","attachmentId":51950472,"attachmentType":"pdf","work_url":"https://www.academia.edu/31625249/The_Fixation_Probability_of_Rare_Mutators_in_Finite_Asexual_Populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/31625249/The_Fixation_Probability_of_Rare_Mutators_in_Finite_Asexual_Populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="74156500" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74156500/Fitness_effects_of_fixed_beneficial_mutations_in_microbial_populations">Fitness effects of fixed beneficial mutations in microbial populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50566687" href="https://independent.academia.edu/PGerrish">Philip Gerrish</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Fitness effects of fixed beneficial mutations in microbial populations","attachmentId":83652996,"attachmentType":"pdf","work_url":"https://www.academia.edu/74156500/Fitness_effects_of_fixed_beneficial_mutations_in_microbial_populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74156500/Fitness_effects_of_fixed_beneficial_mutations_in_microbial_populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="26891607" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26891607/Rate_and_effects_of_spontaneous_mutations_that_affect_fitness_in_mutator_Escherichia_coli">Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50895848" href="https://gulbenkian.academia.edu/IGordo">Isabel Gordo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Philosophical Transactions of the Royal Society B: Biological Sciences, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli","attachmentId":47156033,"attachmentType":"pdf","work_url":"https://www.academia.edu/26891607/Rate_and_effects_of_spontaneous_mutations_that_affect_fitness_in_mutator_Escherichia_coli","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26891607/Rate_and_effects_of_spontaneous_mutations_that_affect_fitness_in_mutator_Escherichia_coli"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="94012927" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/94012927/The_Evolution_of_Mutation_Rate_in_Finite_Asexual_Populations">The Evolution of Mutation Rate in Finite Asexual Populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="251526311" href="https://independent.academia.edu/JeanBaptisteAndr%C3%A92">Jean-Baptiste André</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Genetics, 2005</p><p class="ds-related-work--abstract ds2-5-body-sm">In this article, we model analytically the evolution of mutation rate in asexual organisms. Three selective forces are present. First, everything else being equal, individuals with higher mutation rate have a larger fitness, thanks to the energy and time saved by not replicating DNA accurately. Second, as a flip side, the genome of these individuals is replicated with errors that may negatively affect fitness. Third, and conversely, replication errors have a potential benefit if beneficial mutations are to be generated. Our model describes the fate of modifiers of mutation rate under the three forces and allows us to predict the long-term evolutionary trajectory of mutation rate. We obtain three major results. First, in asexuals, the needs for both adaptation and genome preservation are not evolutionary forces that can stabilize mutation rate at an intermediate optimum. When adaptation has a significant role, it primarily destabilizes mutation rate and yields the emergence of strong...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Evolution of Mutation Rate in Finite Asexual Populations","attachmentId":96590680,"attachmentType":"pdf","work_url":"https://www.academia.edu/94012927/The_Evolution_of_Mutation_Rate_in_Finite_Asexual_Populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/94012927/The_Evolution_of_Mutation_Rate_in_Finite_Asexual_Populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="12558879" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12558879/Spatial_structure_inhibits_the_rate_of_invasion_of_beneficial_mutations_in_asexual_populations">Spatial structure inhibits the rate of invasion of beneficial mutations in asexual populations</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31472871" href="https://independent.academia.edu/Tam%C3%A1s_Cz%C3%A1r%C3%A1n">Tamás L Czárán</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Proceedings of the Royal Society B: Biological Sciences, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Spatial structure inhibits the rate of invasion of beneficial mutations in asexual populations","attachmentId":46088644,"attachmentType":"pdf","work_url":"https://www.academia.edu/12558879/Spatial_structure_inhibits_the_rate_of_invasion_of_beneficial_mutations_in_asexual_populations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12558879/Spatial_structure_inhibits_the_rate_of_invasion_of_beneficial_mutations_in_asexual_populations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" 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