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Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar
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ASPx.AddPressedItems('PageTopControl_Subscribe',[[['dxbButtonPressed_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddDisabledItems('PageTopControl_Subscribe',[[['dxbDisabled_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddSelectedItems('PageTopControl_Subscribe',[[['dxbf'],[''],['CD']]]); ASPx.createControl(ASPxClientButton,'PageTopControl_Subscribe','',{'uniqueID':'ctl00$PageTopControl$Subscribe'},{'Click':function(s, e) { window.open('/subscribe'); }}); //--> </script> </td> </tr> </table> </li> </ul> </div> </div> <div class="main-part cl"> <div class="main-search-container"> <div class="search-form search-centered"> <div class="search-component-container"> <ul class="ul cl"> <li class="fl"> <table id="FieldItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="FieldItems_TL">Loading…</span></td> </tr> </table><div id="FieldItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox FieldItems" id="FieldItems"> <tr> <td style="display:none;"><input id="FieldItems_VI" name="FieldItems_VI" type="hidden" value="kw" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="FieldItems_I" name="ctl00$FieldItems" onfocus="ASPx.EGotFocus('FieldItems')" onblur="ASPx.ELostFocus('FieldItems')" onchange="ASPx.ETextChanged('FieldItems')" value="Keyword" type="text" /></td><td id="FieldItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="FieldItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="FieldItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="FieldItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="FieldItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="FieldItems_DDD_L_VI" type="hidden" name="ctl00$FieldItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="FieldItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="FieldItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="FieldItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Article Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Abstract</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Keyword</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Category</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">MESH Heading</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Grant Agency</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">RCAID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">DOI</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMCID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Author</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Affiliation</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Email</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Journal Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">ISSN</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Publisher</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1279325514" type="text/javascript"> <!-- ASPx.AddDisabledItems('FieldItems_DDD_L',[[['dxeDisabled_MetropolisBlue'],[''],['']]]); ASPx.createControl(ASPxClientListBox,'FieldItems_DDD_L','',{'uniqueID':'ctl00$FieldItems$DDD$L','stateObject':{'CustomCallback':''},'savedSelectedIndex':2,'itemsValue':['title','abstract','kw','subject','mesh','fund','authorid','doi','pmid','pmcid','an','aa','email','journal','issn','p'],'isComboBoxList':true,'hasSampleItem':true,'hoverClasses':['dxeListBoxItemHover_MetropolisBlue'],'selectedClasses':['dxeListBoxItemSelected_MetropolisBlue'],'disabledClasses':['dxeDisabled_MetropolisBlue']},{'SelectedIndexChanged':function (s, e) { ASPx.CBLBSelectedIndexChanged('FieldItems', e); },'ItemClick':function (s, e) { ASPx.CBLBItemMouseUp('FieldItems', e); }},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </div> </div> </div> </div><script id="dxss_1280586772" type="text/javascript"> <!-- ASPx.AddHoverItems('FieldItems_DDD',[[['dxpc-closeBtnHover'],[''],['HCB-1']]]); ASPx.createControl(ASPxClientPopupControl,'FieldItems_DDD','',{'uniqueID':'ctl00$FieldItems$DDD','adjustInnerControlsSizeOnShow':false,'popupAnimationType':'slide','closeAction':'CloseButton','popupHorizontalAlign':'LeftSides','popupVerticalAlign':'Below','isPopupPositionCorrectionOn':false},{'Shown':function (s, e) { ASPx.DDBPCShown('FieldItems', e); }}); //--> </script><script id="dxss_723598773" type="text/javascript"> <!-- ASPx.AddHoverItems('FieldItems',[[['dxeButtonEditButtonHover_MetropolisBlue'],[''],['B-1']]]); ASPx.RemoveHoverItems('FieldItems',[[['B-100']]]); ASPx.AddPressedItems('FieldItems',[[['dxeButtonEditButtonPressed_MetropolisBlue'],[''],['B-1']]]); ASPx.RemovePressedItems('FieldItems',[[['B-100']]]); ASPx.AddDisabledItems('FieldItems',[[['dxeDisabled_MetropolisBlue'],[''],['','I']],[['dxeDisabled_MetropolisBlue dxeButtonDisabled_MetropolisBlue'],[''],['B-1'],,[[{'spriteCssClass':'dxEditors_edtDropDownDisabled_MetropolisBlue'}]],['Img']]]); ASPx.RemoveDisabledItems('FieldItems',[[['B-100'],]]); ASPx.createControl(ASPxClientComboBox,'FieldItems','cbFieldItems',{'callBack':function(arg) { WebForm_DoCallback('ctl00$FieldItems',arg,ASPx.Callback,'FieldItems',ASPx.CallbackError,true); },'uniqueID':'ctl00$FieldItems','autoCompleteAttribute':{'name':'autocomplete','value':'off'},'dropDownHeight':'310px','lastSuccessValue':'kw','islastSuccessValueInit':true},{'SelectedIndexChanged':FieldItems_SelectIndexChanged},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </li> <li class="fl"> <table id="OpeartorItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="OpeartorItems_TL">Loading…</span></td> </tr> </table><div id="OpeartorItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox OpeartorItems" id="OpeartorItems"> <tr> <td style="display:none;"><input id="OpeartorItems_VI" name="OpeartorItems_VI" type="hidden" value="Equals" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="OpeartorItems_I" name="ctl00$OpeartorItems" onfocus="ASPx.EGotFocus('OpeartorItems')" onblur="ASPx.ELostFocus('OpeartorItems')" onchange="ASPx.ETextChanged('OpeartorItems')" value="Equals" type="text" /></td><td id="OpeartorItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="OpeartorItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="OpeartorItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="OpeartorItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="OpeartorItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="OpeartorItems_DDD_L_VI" type="hidden" name="ctl00$OpeartorItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="OpeartorItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="OpeartorItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="OpeartorItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Contains</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Equals</td> </tr> </table> </div></td> </tr> </table><script id="dxss_597138281" type="text/javascript"> <!-- ASPx.AddDisabledItems('OpeartorItems_DDD_L',[[['dxeDisabled_MetropolisBlue'],[''],['']]]); ASPx.createControl(ASPxClientListBox,'OpeartorItems_DDD_L','',{'uniqueID':'ctl00$OpeartorItems$DDD$L','stateObject':{'CustomCallback':''},'savedSelectedIndex':1,'itemsValue':['Contains','Equals'],'isComboBoxList':true,'hasSampleItem':true,'hoverClasses':['dxeListBoxItemHover_MetropolisBlue'],'selectedClasses':['dxeListBoxItemSelected_MetropolisBlue'],'disabledClasses':['dxeDisabled_MetropolisBlue']},{'SelectedIndexChanged':function (s, e) { ASPx.CBLBSelectedIndexChanged('OpeartorItems', e); },'ItemClick':function (s, e) { ASPx.CBLBItemMouseUp('OpeartorItems', e); }},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </div> </div> </div> </div><script id="dxss_24426426" type="text/javascript"> <!-- ASPx.AddHoverItems('OpeartorItems_DDD',[[['dxpc-closeBtnHover'],[''],['HCB-1']]]); ASPx.createControl(ASPxClientPopupControl,'OpeartorItems_DDD','',{'uniqueID':'ctl00$OpeartorItems$DDD','adjustInnerControlsSizeOnShow':false,'popupAnimationType':'slide','closeAction':'CloseButton','popupHorizontalAlign':'LeftSides','popupVerticalAlign':'Below','isPopupPositionCorrectionOn':false},{'Shown':function (s, e) { ASPx.DDBPCShown('OpeartorItems', e); }}); //--> </script><script id="dxss_1793334323" type="text/javascript"> <!-- ASPx.AddHoverItems('OpeartorItems',[[['dxeButtonEditButtonHover_MetropolisBlue'],[''],['B-1']]]); ASPx.RemoveHoverItems('OpeartorItems',[[['B-100']]]); ASPx.AddPressedItems('OpeartorItems',[[['dxeButtonEditButtonPressed_MetropolisBlue'],[''],['B-1']]]); ASPx.RemovePressedItems('OpeartorItems',[[['B-100']]]); ASPx.AddDisabledItems('OpeartorItems',[[['dxeDisabled_MetropolisBlue'],[''],['','I']],[['dxeDisabled_MetropolisBlue dxeButtonDisabled_MetropolisBlue'],[''],['B-1'],,[[{'spriteCssClass':'dxEditors_edtDropDownDisabled_MetropolisBlue'}]],['Img']]]); ASPx.RemoveDisabledItems('OpeartorItems',[[['B-100'],]]); ASPx.createControl(ASPxClientComboBox,'OpeartorItems','cbOpeartorItems',{'callBack':function(arg) { WebForm_DoCallback('ctl00$OpeartorItems',arg,ASPx.Callback,'OpeartorItems',ASPx.CallbackError,true); },'uniqueID':'ctl00$OpeartorItems','autoCompleteAttribute':{'name':'autocomplete','value':'off'},'lastSuccessValue':'Equals','islastSuccessValueInit':true},null,null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </li> <li id="TermInputContainer" class="fl TermInputContainer"> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue input-text SearchTermText dxeTextBoxDefaultWidthSys" id="SearchTerm"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="SearchTerm_I" name="ctl00$SearchTerm" onfocus="ASPx.EGotFocus('SearchTerm')" onblur="ASPx.ELostFocus('SearchTerm')" onchange="ASPx.EValueChanged('SearchTerm')" value="palmitoylation" type="text" /></td> </tr> </table><script id="dxss_543298418" type="text/javascript"> <!-- ASPx.AddDisabledItems('SearchTerm',[[['dxeDisabled_MetropolisBlue'],[''],['','I']]]); ASPx.createControl(ASPxClientTextBox,'SearchTerm','tbSearchTerm',{'uniqueID':'ctl00$SearchTerm','validationGroup':'entryGroup','customValidationEnabled':true,'isValid':true,'errorText':'Invalid value','validationPatterns':[new ASPx.RequiredFieldValidationPattern('Please fill out this field')],'setFocusOnError':true,'display':'None'},null,null,{'decorationStyles':[{'key':'I','className':'dxeInvalid_MetropolisBlue','cssText':''},{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> <span class="search-icon-container"> <a class="search-icon" href="javascript:openCategorySelector(1);"><img src="/Contents/Images/search.png" /></a> </span> </li> <li class="fl"> <div class="dxbButton_MetropolisBlue SearchButton dxbButtonSys dxbTSys" id="SearchArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="SearchArticle_I" class="dxb-hb" value="Find an Article" type="submit" name="ctl00$SearchArticle" /><span class="dx-vam">Find an Article</span> </div> </div><script id="dxss_842240986" type="text/javascript"> <!-- ASPx.AddHoverItems('SearchArticle',[[['dxbButtonHover_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddPressedItems('SearchArticle',[[['dxbButtonPressed_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddDisabledItems('SearchArticle',[[['dxbDisabled_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddSelectedItems('SearchArticle',[[['dxbf'],[''],['CD']]]); ASPx.createControl(ASPxClientButton,'SearchArticle','btnSearch',{'uniqueID':'ctl00$SearchArticle'},{'Click': function(s, e) { if(ASPxClientEdit.ValidateGroup('entryGroup')) { SubmitSearch(); } }}); //--> </script> </li> </ul> <div class="cl"></div> <div class="search-menu"> <span>Find an Article (55810870)</span> <a href="/Categories" target="_blank">Find a Category (125)</a> <a href="/SearchJournal" target="_blank">Find a Journal (6160)</a> <a href="/searchscholar" target="_blank">Find a Scholar (3725)</a> <a href="/searchacademicassistant" target="_blank">Find an Academic Assistant (18)</a> </div> <div class="search-menu" style="text-align:center;"> <span>Find an Article PDF (4648835)</span> <a href="/TodayArticles" target="_self">Today's Articles (4005)</a> <span>Subscriber (50769)</span> </div> </div> </div> </div> <script src="/bundles/UserAcademicAchievement?v=QYKvd9c2mOpOgKt90go7osO6NdxcNzivChzWAq_gw3g1"></script> <script type="text/javascript"> $(function () { try { var sort = getQueryString2('sort'); if (sort != null && sort != '') { if ($("[field='st" + sort + "']").length) { $("[field='st" + sort + "']").addClass("sort-highlight"); } if ($("#" + sort + "sortedCheck").length) { $("#" + sort + "sortedCheck").prop("checked", true); } } $("a.readmore").click(function () { $(this).parent().toggle().next().toggle(); }); $("a.readless").click(function () { $(this).parent().toggle().prev().toggle(); }); var action = getQueryString2('action'); if (action != null && action != '') { if ($("a[name='" + action + "']").length) { $("a[name='" + action + "']").first().click(); } } InitializeResultAnalysisBtn(); } catch (e) { } try { $(".file-container-btn").each(function () { var itemCount = parseInt($(this).attr("item-count")); if (itemCount > 0) { $(this).click(function () { var controlId = $(this).attr("aria-controls"); $("#" + controlId).toggle(); var fa = $(this).children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } }); } }); InitAchievementContents(true); InitYearFacets(); setTimeout(() => setUserContainerBorder(), 1000); setTimeout(() => setUserContainerBorder(), 2000); setTimeout(() => setUserContainerBorder(), 5000); } catch (e) { } AddVisitRecord(2); }); function DeleteArticle(doi) { if (confirm("Confirm Delete the Artilce?")) { LoadingPanel.Show(); try { if (doi != '') { var uri = "/api/BpgUser/DeleteArticle?doi=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, async: false, success: function () { window.location.href = window.location.href; } }); } } catch (e) { } finally { LoadingPanel.Hide(); } } } function Refresh() { CloseEdit(); window.location.href = window.location.href; } function CloseEdit() { pcEditArticleControl.Hide(); } function EditArticle(doi) { pcEditArticleControl.SetContentUrl("/EditUserArticle?Id=" + encodeURIComponent(doi)); pcEditArticleControl.Show(); } function setUserContainerBorder() { try { var leftContainerHeight = $('.user-info-center-container .left-part').outerHeight(); var rightContainerHeight = $('.user-info-center-container .right-part').outerHeight(); if (leftContainerHeight > rightContainerHeight) { $('.user-info-center-container .left-part').css('border-right', '1px solid #C0C0C0'); $('.user-info-center-container .right-part').css('border-left', ''); } else { $('.user-info-center-container .right-part').css('border-left', '1px solid #C0C0C0'); $('.user-info-center-container .left-part').css('border-right', ''); } } catch (e) { } } function ShowUserFriendList() { var expandContainer = $(".expandUserFriend"); $(".user-friend-list").toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function ShowUserContainerList(className, listClassName) { var expandContainer = $("." + className); $("." + listClassName).toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function OpenMessage(id, friendId) { OpenFriendMessage(friendId); $("div[name='countcontainer" + id + "']").hide(); } function DeleteFriend(id) { if (confirm("Confirm Delete the Friend?")) { LoadingPanel.Show(); var uri = "/api/BpgUser/DeleteFriend?id=" + id; $.ajax({ type: "get", url: uri, async: false }).done(function () { window.location.href = window.location.href; }); } } function SelectAllFriend() { $("input[name='checkfriend']").each(function () { $(this).attr("checked", $('#selectAllFriend').prop("checked")); }); onCheckFriendClick(); } function onCheckFriendClick() { var itemArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); }); if (itemArray.length > 0) { $("#BatchMessageContainer").show(); } else { $("#BatchMessageContainer").hide(); } } function SendBatchMessages() { var itemArray = new Array(); var idArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); idArray.push($(this).attr("data-id")); }); if (itemArray.length > 0) { if (itemArray.length == 1) { OpenMessage(idArray[0], itemArray[0]); } else { var friendIds = JSON.stringify(itemArray); OpenBatchFriendMessage(friendIds); } } } function ImportSingleArticle(doi, controlId) { if (doi != '') { LoadingPanel.Show(); var uri = "/api/BpgUser/ImportArticle?doiPmid=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function (data) { LoadingPanel.Hide(); if (data) { alert("Import Successfully!"); var currentControl = $("#" + controlId); currentControl.parent().hide(); } }).always(function () { LoadingPanel.Hide(); }); } } function ImportAllArticles() { LoadingPanel.Show(); var term = getQueryString2('term'); var uri = "/api/BpgUser/ImportArticlesFromSearch?term=" + term; $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function () { LoadingPanel.Hide(); alert("Imorting is executing!"); }).always(function () { LoadingPanel.Hide(); }); } </script> <input type="hidden" name="ctl00$RootHolder$RCAId" id="RCAId" /> <input type="hidden" name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_DownloadArticle',[[['dxbButtonHover_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddPressedItems('RootHolder_DownloadArticle',[[['dxbButtonPressed_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddDisabledItems('RootHolder_DownloadArticle',[[['dxbDisabled_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddSelectedItems('RootHolder_DownloadArticle',[[['dxbf'],[''],['CD']]]); ASPx.createControl(ASPxClientButton,'RootHolder_DownloadArticle','btnDownloadArticle',{'uniqueID':'ctl00$RootHolder$DownloadArticle','useSubmitBehavior':false,'autoPostBackFunction':function(postBackArg) { __doPostBack("ctl00$RootHolder$DownloadArticle", postBackArg); },'causesValidation':false},{'Click': function(s, e) { articleExportPopup.Show(); }}); //--> </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">401</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (123)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (274)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">palmitoylation</label> </div> <div id="yearFacetContainer"> <div class="mnavbar"> <div> Year Published </div> </div> <div class="mnavbox"> <div id="yearFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('year');" class="refine-link-btn" target="_self">Show more</a> <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refineyearcheck" target="_self">Refine</a> </div> </div> </div> <div id="jsFacetContainer"> <div class="mnavbar"> <div> Article Statistics </div> </div> <div class="mnavbox"> <div id="jsFacetItemContainer"> </div> <div class="refine-btn-container cl" name="refinejscheck"> <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejscheck" target="_self">Refine</a> </div> </div> </div> <div class="mnavbar"> <div> Ranked By </div> </div> <div class="mnavbox"> <ul class="ul sortedby-list"> <li> <input type="radio" id="aisortedCheck" onclick="SetSorted('ai')" name="sortedbycheck" value="aisorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('ai')" id="aisorted">Impact Index Per Article</a> </li> <li> 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class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Zhang N</b>, Liu J, Guo R, Yan L, Yang Y, Shi C, Zhang M, Shan B, Li W, Gu J, Xu D. <span class="highlight-field">Palmitoylation</span> licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(17008);'>Mol Cell</em> 2024;<b>84</b>:4419-4435.e10. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39471814' target='_blank'>39471814</a> DOI: <a href='https://dx.doi.org/10.1016/j.molcel.2024.10.002' target='_blank'>10.1016/j.molcel.2024.10.002</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.molcel.2024.10.002','39471814', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.molcel.2024.10.002' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17008);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/01/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.molcel.2024.10.002" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Tumor necrosis factor (TNF)-induced receptor-interacting serine/threonine protein kinase 1 (RIPK1)-mediated cell death, including apoptosis and necroptosis, is increasingly recognized as a major driver of inflammatory diseases. Cell death checkpoints normally suppress RIPK1 kinase to safeguard the organism from its detrimental consequences. However, the mechanisms licensing RIPK1 kinase activity when a protective checkpoint is disabled remain unclear. Here, we identified S-palmitoylation as a licensing modification for RIPK1 kinase. TNF induces RIPK1 palmitoylation, mediated by DHHC5 and dependent on K63-linked ubiquitination of RIPK1, which enhances RIPK1 kinase activity by promoting the homo-interaction of its kinase domain and promotes cell death upon cell death checkpoint blockade. Furthermore, DHHC5 is amplified by fatty acid in the livers of mice with metabolic dysfunction-associated steatohepatitis, contributing to increased RIPK1 cytotoxicity observed in this condition. Our findings reveal that ubiquitination-dependent palmitoylation licenses RIPK1 kinase activity to induce downstream cell death signaling and suggest RIPK1 palmitoylation as a feasible target for inflammatory diseases. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DHHC5%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DHHC5</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RIPK1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RIPK1</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Necroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Necroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Wu M</b>, Zhou X, Zhou X, Wang G, Zeng Y, Li J, Prochownik EV, Wang F, Li Y. ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2024;<b>43</b>:114962. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39522165' target='_blank'>39522165</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.114962' target='_blank'>10.1016/j.celrep.2024.114962</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.114962','39522165', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.celrep.2024.114962' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.celrep.2024.114962" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cholesterol metabolism reprogramming plays essential roles in hepatocellular carcinoma (HCC). However, precisely how cholesterol metabolism is dysregulated is not clear. Here, we show that the palmitoyltransferase ZDHHC3 and depalmitoylase ABHD17A regulate HCC cell cholesterol biosynthesis by dynamically S-acylating SREBP cleavage-activating protein (SCAP). SCAP S-acylation by ZDHHC3 at C264 antagonizes HACE1-mediated SCAP ubiquitination. Intriguingly, SREBP2 transcriptionally upregulates ZDHHC3 to form a positive feedback loop, which explains why negative feedback regulation of SCAP/SREBP2 signaling fails in HCC. Increased cholesterol in the tumor microenvironment (TME) restrains CD4+ T cell cytotoxicity. Hence, the cholesterol metabolism reprogramming and cholesterol level alternation in the TME cooperate to promote HCC development. We identified a small-molecule inhibitor of ZDHHC3 that, combined with anti-PD-1 immunotherapy, inhibited diethyl nitrosamine (DEN)/CCl4-induced HCC growth in mice. ZDHHC3-mediated SCAP S-acylation reprograms cholesterol metabolism and promotes HCC immune escape. ZDHHC3 is thus identified as a rational chemotherapy target for HCC. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HCC%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HCC</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SCAP%2fSREBP2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SCAP/SREBP2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ZDHHC3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ZDHHC3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cholesterol+metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cholesterol metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ubiquitination%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ubiquitination</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Zhang N</b>, Yang Y, Xu D. Emerging roles of <span class="highlight-field">palmitoylation</span> in pyroptosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(22955);'>Trends Cell Biol</em> 2024:S0962-8924(24)00211-3. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39521664' target='_blank'>39521664</a> DOI: <a href='https://dx.doi.org/10.1016/j.tcb.2024.10.005' target='_blank'>10.1016/j.tcb.2024.10.005</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.tcb.2024.10.005','39521664', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.tcb.2024.10.005' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(22955);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.tcb.2024.10.005" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pyroptosis is a lytic, proinflammatory type of programmed cell death crucial for the immune response to pathogen infections and internal danger signals. Gasdermin D (GSDMD) acts as the pore-forming protein in pyroptosis following inflammasome activation. While recent research has improved our understanding of pyroptosis activation and execution, many aspects regarding the molecular mechanisms controlling inflammasome and GSDMD activation remain to be elucidated. A growing body of literature has shown that S-palmitoylation, a reversible post-translational modification (PTM) that attaches palmitate to cysteine residues, contributes to multi-layered regulation of pyroptosis. This review summarizes the emerging roles of S-palmitoylation in pyroptosis research with a focus on mechanisms that regulate NLRP3 inflammasome and GSDMD activation. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gasdermin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gasdermin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammasome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pyroptosis</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Hirata Y</b>, Brems H, Van der Auweraer S, Ohyagi M, Iizuka M, Mise-Omata S, Ito M, Messiaen L, Mizuno S, Takahashi S, Legius E, Yoshimura A. Legius Syndrome mutations in the Ras-regulator SPRED1 abolish its membrane localization and potentially cause neurodegeneration. <em class='incite-journal-name' onclick='ShowInCiteJournal(12370);'>J Biol Chem</em> 2024:107969. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39510187' target='_blank'>39510187</a> DOI: <a href='https://dx.doi.org/10.1016/j.jbc.2024.107969' target='_blank'>10.1016/j.jbc.2024.107969</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jbc.2024.107969','39510187', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jbc.2024.107969' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12370);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/15/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.jbc.2024.107969" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The SPRED family proteins act as negative regulators of the Ras-ERK pathway: the N-terminal EVH1 domain interacts with the Ras-GAP domain (GRD) of the NF1 protein, while the C-terminal Sprouty-related (SPR) domain promotes membrane localization of SPRED, thereby recruiting NF-1 to Ras. Loss-of-function mutations in the hSPRED1 cause Legius syndrome in an autosomal dominant manner. In this study, we investigated the effects of missense mutations in the SPR domain identified in patients with Legius syndrome. Among 18 mutations we examined, six (C368S, M369L, V408E, P415A, P415L and P422R) have defects in the palmitoylation of the SPRED1 protein, losing plasma membrane localization and forming cytoplasmic granular aggregates. To evaluate the in vivo effects of SPR mutations, knock-in (KI) mice with P415A and P415V substitutions or M417Afs*4, a C-terminal 28 amino acid deletion, were generated. All these KI mice exhibited cranial malformations, a characteristic feature of Legius syndrome. However, both P415A and P415V mutants formed granular aggregates, whereas M417Afs*4 showed a diffuse cytoplasmic distribution, and Spred1P415A and Spred1P415V mice, but not Spred1M417Afs∗4 mice, developed cerebellar ataxia and Purkinje cell loss with age. These data suggest that in addition to loss of palmitoylation, the C-terminal region is required for the granular aggregate formation and Purkinje cell loss. The autophagy inducer spermidine rescued the ataxia phenotypes and Purkinje cell loss in Spred1P415A mice. These results suggest that some, but not all, SPR mutations that lose lipid modification induce abnormal cytoplasmic aggregation, which could be a target for autophagic clearance, and potentially cause neurodegenerative diseases. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SPRED1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SPRED1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22membrane+localization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">membrane localization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurodegeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurodegeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22spermidine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">spermidine</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Saidjalolov S</b>, Chen XX, Moreno J, Cognet M, Wong-Dilworth L, Bottanelli F, Sakai N, Matile S. Asparagusic Golgi Trackers. <em>JACS AU</em> 2024;<b>4</b>:3759-3765. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39483219' target='_blank'>39483219</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522900' target='_blank'>PMC11522900</a> DOI: <a href='https://dx.doi.org/10.1021/jacsau.4c00487' target='_blank'>10.1021/jacsau.4c00487</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1021/jacsau.4c00487','39483219', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(5);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1021/jacsau.4c00487' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1021/jacsau.4c00487');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/03/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1021/jacsau.4c00487" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Thiol-mediated uptake (TMU) is thought to occur through dynamic covalent cascade exchange networks. Here we show that the cascade accounting for TMU of asparagusic acid derivatives (AspA) ends in the Golgi apparatus (G) and shifts from disulfide to thioester exchange with palmitoyl transferases as the final exchange partner. As a result, AspA combined with pH-sensitive fluoresceins, red-shifted silicon-rhodamines, or mechanosensitive flipper probes selectively labels the Golgi apparatus in fluorescence microscopy images in living and fixed cells. AspA Golgi trackers work without cellular engineering and excel with speed, simplicity, generality, and compatibility with G/ER and cis/trans discrimination, morphological changes, anterograde vesicular trafficking, and superresolution imaging by stimulated emission depletion microscopy. Golgi flippers in particular can image membrane order and tension in the Golgi and, if desired, at the plasma membrane during TMU. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22fluorescent+probes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">fluorescent probes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22golgi+trackers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">golgi trackers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bioimaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bioimaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22fluorescent+flippers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">fluorescent flippers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cellular+uptake%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cellular uptake</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22thiol-mediated%5cnuptake%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">thiol-mediated uptake</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Deutsche+Forschungsgemeinschaft%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Deutsche Forschungsgemeinschaft</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Centre+of+Competence+in+Research+(NCCR)+Molecular+Systems+Engineering%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Centre of Competence in Research (NCCR) Molecular Systems Engineering</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Freie+Universit%c3%83%c2%a4t+Berlin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Freie Universität Berlin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Universit%c3%83%c2%a9+de+Gen%c3%83%c2%a8ve%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Université de Genève</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schweizerischer+Nationalfonds+zur+F%c3%83%c2%b6rderung+der+Wissenschaftlichen+Forschung%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung</a></li></ul> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Wang Z</b>, Qiu M, Ji Y, Chai K, Liu C, Xu F, Guo F, Tan J, Liu R, Qiao W. <span class="highlight-field">Palmitoylation</span> of SARS-CoV-2 Envelope protein is central to virus particle formation. <em class='incite-journal-name' onclick='ShowInCiteJournal(15732);'>J Virol</em> 2024;<b>98</b>:e0107224. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39287388' target='_blank'>39287388</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495019' target='_blank'>PMC11495019</a> DOI: <a href='https://dx.doi.org/10.1128/jvi.01072-24' target='_blank'>10.1128/jvi.01072-24</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1128/jvi.01072-24','39287388', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(6);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1128/jvi.01072-24' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(15732);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/19/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1128/jvi.01072-24" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The Envelope (E) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an integral structural protein in the virus particles. However, its role in the assembly of virions and the underlying molecular mechanisms are yet to be elucidated, including whether the function of E protein is regulated by post-translational modifications. In the present study, we report that SARS-CoV-2 E protein is palmitoylated at C40, C43, and C44 by palmitoyltransferases zDHHC3, 6, 12, 15, and 20. Mutating these three cysteines to serines (C40/43/44S) reduced the stability of E protein, decreased the interaction of E with structural proteins Spike, Membrane, and Nucleocapsid, and thereby inhibited the production of virus-like particles (VLPs) and VLP-mediated luciferase transcriptional delivery. Specifically, the C40/43/44S mutation of E protein reduced the density of VLPs. Collectively, these results demonstrate that palmitoylation of E protein is vital for its function in the assembly of SARS-CoV-2 particles.IMPORTANCEIn this study, we systematically examined the biochemistry of palmitoylation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) E protein and demonstrated that palmitoylation of SARS-CoV-2 E protein is required for virus-like particle (VLP) production and maintaining normal particle density. These results suggest that palmitoylated E protein is central for proper morphogenesis of SARS-CoV-2 VLPs in densities required for viral infectivity. This study presents a significant advancement in the understanding of how palmitoylation of viral proteins is vital for assembling SARS-CoV-2 particles and supports that palmitoyl acyltransferases can be potential therapeutic targets for the development of SARS-CoV-2 inhibitors. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Envelope+protein%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Envelope protein</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22virus-like+particles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">virus-like particles</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Virus+Assembly%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Virus Assembly</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coronavirus+Envelope+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Coronavirus Envelope Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coronavirus+Envelope+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Coronavirus Envelope Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Virion%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Virion/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acyltransferases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acyltransferases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acyltransferases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acyltransferases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%2fvirology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19/virology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HEK293+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HEK293 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Processing%2c+Post-Translational%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Processing, Post-Translational</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spike+Glycoprotein%2c+Coronavirus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spike Glycoprotein, Coronavirus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spike+Glycoprotein%2c+Coronavirus%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spike Glycoprotein, Coronavirus/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spike+Glycoprotein%2c+Coronavirus%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spike Glycoprotein, Coronavirus/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Key+international+Cooperation+Project+of+the+National+Key+Research+and+Development+Program+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2018YFE0107600 Key international Cooperation Project of the National Key Research and Development Program of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAMS+Innovation+Fund+for+Medical+Sciences%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CIFMS 2022-I2M-CoV19-002 CAMS Innovation Fund for Medical Sciences</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China+(NSFC)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82271802, 82241073 National Natural Science Foundation of China (NSFC)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fundamental+Research+Funds+for+the+Central+Universities%2c+Nankai+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">63201023 Fundamental Research Funds for the Central Universities, Nankai University</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fundamental+Research+Funds+for+the+Central+Universities%2c+Nankai+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">63201102 Fundamental Research Funds for the Central Universities, Nankai University</a></li></ul> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Wlodarczyk J</b>, Bhattacharyya R, Dore K, Ho GPH, Martin DDO, Mejias R, Hochrainer K. Altered Protein <span class="highlight-field">Palmitoylation</span> as Disease Mechanism in Neurodegenerative Disorders. <em class='incite-journal-name' onclick='ShowInCiteJournal(169709);'>J Neurosci</em> 2024;<b>44</b>:e1225242024. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39358031' target='_blank'>39358031</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450541' target='_blank'>PMC11450541</a> DOI: <a href='https://dx.doi.org/10.1523/jneurosci.1225-24.2024' target='_blank'>10.1523/jneurosci.1225-24.2024</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1523/jneurosci.1225-24.2024','39358031', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(7);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1523/jneurosci.1225-24.2024' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169709);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/04/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1523/jneurosci.1225-24.2024" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Palmitoylation, a lipid-based posttranslational protein modification, plays a crucial role in regulating various aspects of neuronal function through altering protein membrane-targeting, stabilities, and protein-protein interaction profiles. Disruption of palmitoylation has recently garnered attention as disease mechanism in neurodegeneration. Many proteins implicated in neurodegenerative diseases and associated neuronal dysfunction, including but not limited to amyloid precursor protein, β-secretase (BACE1), postsynaptic density protein 95, Fyn, synaptotagmin-11, mutant huntingtin, and mutant superoxide dismutase 1, undergo palmitoylation, and recent evidence suggests that altered palmitoylation contributes to the pathological characteristics of these proteins and associated disruption of cellular processes. In addition, dysfunction of enzymes that catalyze palmitoylation and depalmitoylation has been connected to the development of neurological disorders. This review highlights some of the latest advances in our understanding of palmitoylation regulation in neurodegenerative diseases and explores potential therapeutic implications. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurodegeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurodegeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodegenerative+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodegenerative Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodegenerative+Diseases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodegenerative Diseases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Processing%2c+Post-Translational%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Processing, Post-Translational</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 AG067049 NIA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NINDS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R21 NS085358 NINDS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NINDS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">K08 NS110876 NINDS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NICHD+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 HD052680 NICHD NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIMH+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 MH112808 NIMH NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NINDS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 NS109588 NINDS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cure+Alzheimer%27s+Fund+(CAF)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cure Alzheimer's Fund (CAF)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Science+Centre%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Science Centre</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22American+Parkinson+Disease+Association+(APDA)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">American Parkinson Disease Association (APDA)</a></li></ul> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Bu L</b>, Wang H, Zhang S, Zhang Y, Liu M, Zhang Z, Wu X, Jiang Q, Wang L, Xie W, He M, Zhou Z, Cheng C, Guo J. Targeting APT2 improves MAVS <span class="highlight-field">palmitoylation</span> and antiviral innate immunity. <em class='incite-journal-name' onclick='ShowInCiteJournal(17008);'>Mol Cell</em> 2024;<b>84</b>:3513-3529.e5. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39255795' target='_blank'>39255795</a> DOI: <a href='https://dx.doi.org/10.1016/j.molcel.2024.08.014' target='_blank'>10.1016/j.molcel.2024.08.014</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.molcel.2024.08.014','39255795', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.molcel.2024.08.014' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17008);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/12/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.molcel.2024.08.014" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Innate immunity serves as the primary defense against viral and microbial infections in humans. The precise influence of cellular metabolites, especially fatty acids, on antiviral innate immunity remains largely elusive. Here, through screening a metabolite library, palmitic acid (PA) has been identified as a key modulator of antiviral infections in human cells. Mechanistically, PA induces mitochondrial antiviral signaling protein (MAVS) palmitoylation, aggregation, and subsequent activation, thereby enhancing the innate immune response. The palmitoyl-transferase ZDHHC24 catalyzes MAVS palmitoylation, thereby boosting the TBK1-IRF3-interferon (IFN) pathway, particularly under conditions of PA stimulation or high-fat-diet-fed mouse models, leading to antiviral immune responses. Additionally, APT2 de-palmitoylates MAVS, thus inhibiting antiviral signaling, suggesting that its inhibitors, such as ML349, effectively reverse MAVS activation in response to antiviral infections. These findings underscore the critical role of PA in regulating antiviral innate immunity through MAVS palmitoylation and provide strategies for enhancing PA intake or targeting APT2 for combating viral infections. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22APT2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">APT2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAVS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAVS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ZDHHC24%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ZDHHC24</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22innate+immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">innate immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Palmitic+Acid%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Palmitic Acid/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HEK293+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HEK293 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interferon+Regulatory+Factor-3%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interferon Regulatory Factor-3/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interferon+Regulatory+Factor-3%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interferon Regulatory Factor-3/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interferon+Regulatory+Factor-3%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interferon Regulatory Factor-3/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acyltransferases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acyltransferases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acyltransferases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acyltransferases/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acyltransferases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acyltransferases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Serine-Threonine+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Serine-Threonine Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Serine-Threonine+Kinases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Serine-Threonine Kinases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antiviral+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antiviral Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Proteins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Koster KP</b>, Green WN. Editorial: Role of protein <span class="highlight-field">palmitoylation</span> in synaptic plasticity and neuronal differentiation, volume II. <em class='incite-journal-name' onclick='ShowInCiteJournal(9362);'>Front Synaptic Neurosci</em> 2024;<b>16</b>:1473989. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39319198' target='_blank'>39319198</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420002' target='_blank'>PMC11420002</a> DOI: <a href='https://dx.doi.org/10.3389/fnsyn.2024.1473989' target='_blank'>10.3389/fnsyn.2024.1473989</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fnsyn.2024.1473989','39319198', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fnsyn.2024.1473989' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9362);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/26/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.3389/fnsyn.2024.1473989" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22depalmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">depalmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22post-translational+modification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">post-translational modification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22synaptic+plasticity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">synaptic plasticity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22synaptic+transmission%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">synaptic transmission</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Nie L</b>, Fei C, Fan Y, Dang F, Zhao Z, Zhu T, Wu X, Dai T, Balasubramanian A, Pan J, Hu Y, Luo HR, Wei W, Chen J. Consecutive <span class="highlight-field">palmitoylation</span> and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation. <em class='incite-journal-name' onclick='ShowInCiteJournal(17008);'>Mol Cell</em> 2024;<b>84</b>:3336-3353.e7. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39173637' target='_blank'>39173637</a> DOI: <a href='https://dx.doi.org/10.1016/j.molcel.2024.08.001' target='_blank'>10.1016/j.molcel.2024.08.001</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.molcel.2024.08.001','39173637', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.molcel.2024.08.001' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17008);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/07/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/24/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.molcel.2024.08.001" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">NLRP3 inflammasome activation, essential for cytokine secretion and pyroptosis in response to diverse stimuli, is closely associated with various diseases. Upon stimulation, NLRP3 undergoes subcellular membrane trafficking and conformational rearrangements, preparing itself for inflammasome assembly at the microtubule-organizing center (MTOC). Here, we elucidate an orchestrated mechanism underlying these ordered processes using human and murine cells. Specifically, NLRP3 undergoes palmitoylation at two sites by palmitoyl transferase zDHHC1, facilitating its trafficking between subcellular membranes, including the mitochondria, trans-Golgi network (TGN), and endosome. This dynamic trafficking culminates in the localization of NLRP3 to the MTOC, where LATS1/2, pre-recruited to MTOC during priming, phosphorylates NLRP3 to further facilitate its interaction with NIMA-related kinase 7 (NEK7), ultimately leading to full NLRP3 activation. Consistently, Zdhhc1-deficiency mitigated LPS-induced inflammation and conferred protection against mortality in mice. Altogether, our findings provide valuable insights into the regulation of NLRP3 membrane trafficking and inflammasome activation, governed by palmitoylation and phosphorylation events. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LATS1%2f2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LATS1/2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammasome+activation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammasome activation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22membrane+trafficking%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">membrane trafficking</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microtubule-organizing+center%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microtubule-organizing center</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22phosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">phosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22zDHHC1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">zDHHC1</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLR+Family%2c+Pyrin+Domain-Containing+3+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLR Family, Pyrin Domain-Containing 3 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLR+Family%2c+Pyrin+Domain-Containing+3+Protein%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLR Family, Pyrin Domain-Containing 3 Protein/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammasomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammasomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammasomes%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammasomes/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Transport%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Transport</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HEK293+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HEK293 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIMA-Related+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NIMA-Related Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIMA-Related+Kinases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NIMA-Related Kinases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acyltransferases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acyltransferases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acyltransferases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acyltransferases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microtubule-Organizing+Center%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microtubule-Organizing Center/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22trans-Golgi+Network%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">trans-Golgi Network/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Shao XJ</b>, Wang W, Xu AX, Qi XT, Cai MY, Du WX, Cao J, He QJ, Ying MD, Yang B. Palmitoyltransferase ZDHHC3 is essential for the oncogenic activity of PML/RARα in acute promyelocytic leukemia. <em class='incite-journal-name' onclick='ShowInCiteJournal(743);'>Acta Pharmacol Sin</em> 2024:10.1038/s41401-024-01371-z. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39227737' target='_blank'>39227737</a> DOI: <a href='https://dx.doi.org/10.1038/s41401-024-01371-z' target='_blank'>10.1038/s41401-024-01371-z</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41401-024-01371-z','39227737', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41401-024-01371-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(743);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/05/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1038/s41401-024-01371-z" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The oncogenic fusion protein promyelocytic leukemia/retinoic acid receptor alpha (PML/RARα) is critical for acute promyelocytic leukemia (APL). PML/RARα initiates APL by blocking the differentiation and increasing the self-renewal of leukemic cells. The standard clinical therapies all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), which induce PML/RARα proteolysis, have dramatically improved the prognosis of APL patients. However, the emergence of mutations conferring resistance to ATRA and ATO has created challenges in the treatment of APL patients. Exploring pathways that modulate the oncogenic activity of PML/RARα could help develop novel therapeutic strategies for APL, particularly for drug-resistant APL. Herein, we demonstrated for the first time that palmitoylation of PML/RARα was a critical determinant of its oncogenic activity. PML/RARα palmitoylation was found to be catalyzed mainly by the palmitoyltransferase ZDHHC3. Mechanistically, ZDHHC3-mediated palmitoylation regulated the oncogenic transcriptional activity of PML/RARα and APL pathogenesis. The knockdown or overexpression of ZDHHC3 had respective effects on the expression of proliferation- and differentiation-related genes. Consistently, the depletion or inhibition of ZDHHC3 could significantly arrest the malignant progression of APL, particularly drug-resistant APL, whereas ZDHHC3 overexpression appeared to have a promoting effect on the malignant progression of APL. Thus, our study not only reveals palmitoylation as a novel regulatory mechanism that modulates PML/RARα oncogenic activity but also identifies ZDHHC3 as a potential therapeutic target for APL, including drug-resistant APL. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PML%2fRAR%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PML/RARα</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ZDHHC3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ZDHHC3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22acute+promyelocytic+leukemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">acute promyelocytic leukemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug+resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Yang S</b>, Li M, Lian G, Wu Y, Cui J, Wang L. ABHD8 antagonizes inflammation by facilitating chaperone-mediated autophagy-mediated degradation of NLRP3. <em class='incite-journal-name' onclick='ShowInCiteJournal(3190);'>Autophagy</em> 2024:1-14. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39225180' target='_blank'>39225180</a> DOI: <a href='https://dx.doi.org/10.1080/15548627.2024.2395158' target='_blank'>10.1080/15548627.2024.2395158</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15548627.2024.2395158','39225180', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15548627.2024.2395158' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3190);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/04/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1080/15548627.2024.2395158" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The NLRP3 inflammasome is a multiprotein complex that plays a vital role in the innate immune system in response to microbial infections and endogenous danger signals. Aberrant activation of the NLRP3 inflammasome is implicated in a spectrum of inflammatory and autoimmune diseases, emphasizing the necessity for precise regulation of the NLRP3 inflammasome to maintain immune homeostasis. The protein level of NLRP3 is a limiting step for inflammasome activation, which must be tightly controlled to avoid detrimental consequences. Here, we demonstrate that ABHD8, a member of the α/β-hydrolase domain-containing (ABHD) family, interacts with NLRP3 and promotes its degradation through the chaperone-mediated autophagy (CMA) pathway. ABHD8 acts as a scaffold to recruit palmitoyltransferase ZDHHC12 to NLRP3 for its palmitoylation as well as subsequent CMA-mediated degradation. Notably, ABHD8 deficiency results in the stabilization of NLRP3 protein and promotes NLRP3 inflammasome activation. We further confirm that ABHD8 overexpression ameliorates LPS- or alum-triggered NLRP3 inflammasome activation in vivo. Interestingly, the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impairs the ABHD8-NLRP3 association, resulting in an elevation in NLRP3 protein level and excessive inflammasome activation. These findings demonstrate that ABHD8 May represent a potential therapeutic target in conditions associated with NLRP3 inflammasome dysregulation.Abbreviations: 3-MA: 3-methyladenine; ABHD: α/β-hydrolase domain-containing; BMDMs: Bone marrow-derived macrophages; CFZ: carfilzomib; CHX: cycloheximide; CMA: chaperone-mediated autophagy; CQ: chloroquine; DAMPs: danger/damage-associated molecular patterns; HSPA8/HSC70: heat shock protein family A (Hsp70) member 8; LAMP2A: lysosomal associated membrane protein 2A; NH4Cl: ammonium chloride; NLRP3: NLR family pyrin domain containing 3; PAMPs: pathogen-associated molecular patterns; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ABHD8%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ABHD8</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CMA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CMA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammasome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Lin J</b>, Lyu Z, Feng H, Xie H, Peng J, Zhang W, Zheng J, Zheng J, Pan Z, Li Y. CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by inhibiting <span class="highlight-field">palmitoylation</span> of the GSDME-C domain to induce chemoresistance of colorectal cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(7942);'>Drug Resist Updat</em> 2024;<b>76</b>:101097. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38861804' target='_blank'>38861804</a> DOI: <a href='https://dx.doi.org/10.1016/j.drup.2024.101097' target='_blank'>10.1016/j.drup.2024.101097</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.drup.2024.101097','38861804', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.drup.2024.101097' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7942);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/03/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/13/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.drup.2024.101097" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Although oxaliplatin (OXA) is widely used in the frontline treatment of colorectal cancer (CRC), CRC recurrence is commonly observed due to OXA resistance. OXA resistance is associated with a number of factors, including abnormal regulation of pyroptosis. It is therefore important to elucidate the abnormal regulatory mechanism underlying pyroptosis. Here, we identified that the circular RNA circPDIA3 played an important role in chemoresistance in CRC. CircPDIA3 could induce chemoresistance in CRC by inhibiting pyroptosis both in vitro and in vivo. Mechanistically, RIP, RNA pull-down and co-IP assays revealed that circPDIA3 directly bonded to the GSDME-C domain, subsequently enhanced the autoinhibitory effect of the GSDME-C domain through blocking the GSDME-C domain palmitoylation by ZDHHC3 and ZDHHC17, thereby restraining pyroptosis. Additionally, it was found that the circPDIA3/miR-449a/XBP1 positive feedback loop increased the expression of circPDIA3 to induce chemoresistance. Furthermore, our clinical data and patient-derived tumor xenograft (PDX) models supported the positive association of circPDIA3 with development of chemoresistance in CRC patients. Taken together, our findings demonstrated that circPDIA3 could promote chemoresistance by amplifying the autoinhibitory effect of the GSDME-C domain through inhibition of the GSDME-C domain palmitoylation in CRC. This study provides novel insights into the mechanism of circRNA in regulating pyroptosis and providing a potential therapeutic target for reversing chemoresistance of CRC. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDME%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDME</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chemoresistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chemoresistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22circular+RNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">circular RNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pyroptosis</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acyltransferases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acyltransferases/genetics</a></li><li><a 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Disulfide-Isomerases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Disulfide-Isomerases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Disulfide-Isomerases/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Zhang X</b>, Thomas GM. Recruitment, regulation, and release: Control of signaling enzyme localization and function by reversible S-acylation. <em class='incite-journal-name' onclick='ShowInCiteJournal(12370);'>J Biol Chem</em> 2024;<b>300</b>:107696. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39168183' target='_blank'>39168183</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417247' target='_blank'>PMC11417247</a> DOI: <a href='https://dx.doi.org/10.1016/j.jbc.2024.107696' target='_blank'>10.1016/j.jbc.2024.107696</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jbc.2024.107696','39168183', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jbc.2024.107696' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12370);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/23/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.jbc.2024.107696" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">An ever-growing number of studies highlight the importance of S-acylation, a reversible protein-lipid modification, for diverse aspects of intracellular signaling. In this review, we summarize the current understanding of how S-acylation regulates perhaps the best-known class of signaling enzymes, protein kinases. We describe how S-acylation acts as a membrane targeting signal that localizes certain kinases to specific membranes, and how such membrane localization in turn facilitates the assembly of signaling hubs consisting of an S-acylated kinase's upstream activators and/or downstream targets. We further discuss recent findings that S-acylation can control additional aspects of the function of certain kinases, including their interactions and, surprisingly, their activity, and how such regulation might be exploited for potential therapeutic gain. We go on to describe the roles and regulation of de-S-acylases and how extracellular signals drive dynamic (de)S-acylation of certain kinases. We discuss how S-acylation has the potential to lead to "emergent properties" that alter the temporal profile and/or salience of intracellular signaling events. We close by giving examples of other S-acylation-dependent classes of signaling enzymes and by discussing how recent biological and technological advances should facilitate future studies into the functional roles of S-acylation-dependent signaling. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DLK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DLK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22JNK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">JNK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22axon+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">axon degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22axon+transport%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">axon transport</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune signaling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurodegeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurodegeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22oncogene%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">oncogene</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22protein+trafficking%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">protein trafficking</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22retrograde+signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">retrograde signaling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22synapse%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">synapse</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Membrane%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Membrane/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Thornburg-Suresh EJC</b>, Summers DW. Microtubules, Membranes, and Movement: New Roles for Stathmin-2 in Axon Integrity. <em class='incite-journal-name' onclick='ShowInCiteJournal(14719);'>J Neurosci Res</em> 2024;<b>102</b>:e25382. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39253877' target='_blank'>39253877</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407747' target='_blank'>PMC11407747</a> DOI: <a href='https://dx.doi.org/10.1002/jnr.25382' target='_blank'>10.1002/jnr.25382</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/jnr.25382','39253877', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(15);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/jnr.25382' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14719);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1002/jnr.25382" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurons establish functional connections responsible for how we perceive and react to the world around us. Communication from a neuron to its target cell occurs through a long projection called an axon. Axon distances can exceed 1 m in length in humans and require a dynamic microtubule cytoskeleton for growth during development and maintenance in adulthood. Stathmins are microtubule-associated proteins that function as relays between kinase signaling and microtubule polymerization. In this review, we describe the prolific role of Stathmins in microtubule homeostasis with an emphasis on emerging roles for Stathmin-2 (Stmn2) in axon integrity and neurodegeneration. Stmn2 levels are altered in Amyotrophic Lateral Sclerosis and loss of Stmn2 provokes motor and sensory neuropathies. There is growing potential for employing Stmn2 as a disease biomarker or even a therapeutic target. Meeting this potential requires a mechanistic understanding of emerging complexity in Stmn2 function. In particular, Stmn2 palmitoylation has a surprising contribution to axon maintenance through undefined mechanisms linking membrane association, tubulin interaction, and axon transport. Exploring these connections will reveal new insight on neuronal cell biology and novel opportunities for disease intervention. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ALS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ALS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stmn2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stmn2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22axon+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">axon degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cytoskeleton%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cytoskeleton</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurodegeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurodegeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stathmin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stathmin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microtubules%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microtubules/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Axons%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Axons/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Axons%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Axons/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Membrane%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Membrane/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amyotrophic+Lateral+Sclerosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amyotrophic Lateral Sclerosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amyotrophic+Lateral+Sclerosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amyotrophic Lateral Sclerosis/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NINDS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 NS126191 NINDS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01NS126191 NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Felipe R</b>, Sarmiento-Jiménez J, Camafeita E, Vázquez J, López-Corcuera B. Role of <span class="highlight-field">palmitoylation</span> on the neuronal glycine transporter GlyT2. <em class='incite-journal-name' onclick='ShowInCiteJournal(14695);'>J Neurochem</em> 2024;<b>168</b>:2056-2072. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39032066' target='_blank'>39032066</a> DOI: <a href='https://dx.doi.org/10.1111/jnc.16181' target='_blank'>10.1111/jnc.16181</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/jnc.16181','39032066', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(16);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/jnc.16181' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14695);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1111/jnc.16181" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The neuronal glycine transporter GlyT2 removes glycine from the synaptic cleft through active Na+, Cl-, and glycine cotransport contributing to the termination of the glycinergic signal as well as supplying substrate to the presynaptic terminal for the maintenance of the neurotransmitter content in synaptic vesicles. Patients with mutations in the human GlyT2 gene (SLC6A5), develop hyperekplexia or startle disease (OMIM 149400), characterized by hypertonia and exaggerated startle responses to trivial stimuli that may have lethal consequences in the neonates as a result of apnea episodes. Post-translational modifications in cysteine residues of GlyT2 are an aspect of structural interest we analyzed. Our study is compatible with a reversible and short-lived S-acylation in spinal cord membranes, detectable by biochemical and proteomics methods (acyl-Rac binding and IP-ABE) confirmed with positive and negative controls (palmitoylated and non-palmitoylated proteins). According to a short-lived modification, direct labeling using click chemistry was faint but mostly consistent. We have analyzed the physiological properties of a GlyT2 mutant lacking the cysteines with high prediction of palmitoylation and the mutant is less prone to be included in lipid rafts, an effect also observed upon treatment with the palmitoylation inhibitor 2-bromopalmitate. This work demonstrates there are determinants of lipid raft inclusion associated with the GlyT2 mutated cysteines, which are presumably modified by palmitoylation. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GlyT2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GlyT2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cysteine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cysteine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glycine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glycine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lipid+rafts%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lipid rafts</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22transporter%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">transporter</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; 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text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Leishman S</b>, Aljadeed NM, Qian L, Cockcroft S, Behmoaras J, Anand PK. Fatty acid synthesis promotes inflammasome activation through NLRP3 <span class="highlight-field">palmitoylation</span>. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2024;<b>43</b>:114516. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39024103' target='_blank'>39024103</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.114516' target='_blank'>10.1016/j.celrep.2024.114516</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.114516','39024103', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.celrep.2024.114516' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/20/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1016/j.celrep.2024.114516" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Despite its significance, the role of lipid metabolism in NLRP3 inflammasome remains elusive. Here, we reveal a critical role for fatty acid synthase (FASN) in NLRP3 inflammasome activation. We demonstrate that pharmacological or genetic depletion of FASN dampens NLRP3 activation in primary mouse and human macrophages and in mice. This disruption in NLRP3 activation is contingent upon FASN activity. Accordingly, abolishing cellular palmitoylation, a post-translational modification in which the FASN product palmitate is reversibly conjugated to cysteine residues of target proteins, blunts inflammasome signaling. Correspondingly, an acyl-biotin exchange assay corroborated NLRP3 palmitoylation. Mechanistically, Toll-like receptor (TLR) ligation introduces palmitoylation at NLRP3 Cys898, permitting NLRP3 translocation to dispersed trans-Golgi network (dTGN) vesicles, the site of inflammasome assembly, upon NLRP3 activation. Accordingly, the NLRP3 Cys898 mutant exhibits reduced palmitoylation, limited translocation to the dTGN compartment, and diminished inflammasome activation. These results underscore mechanistic insights through which lipid metabolism licenses NLRP3 inflammasome assembly and activation. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Immunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FASN%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FASN</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SREBP1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SREBP1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunometabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunometabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammasome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lipid+biosynthesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lipid biosynthesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lipid+metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lipid metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22trans+Golgi+network%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">trans Golgi network</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Acid+Synthase%2c+Type+I%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Acid Synthase, Type I/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Acid+Synthase%2c+Type+I%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Acid Synthase, Type I/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Acids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Acids/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammasomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammasomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLR+Family%2c+Pyrin+Domain-Containing+3+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLR Family, Pyrin Domain-Containing 3 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Transport%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Transport/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22trans-Golgi+Network%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">trans-Golgi Network/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Xu J</b>, Pickard JM, Núñez G. FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 <span class="highlight-field">palmitoylation</span>. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2024;<b>43</b>:114609. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39116210' target='_blank'>39116210</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11398858' target='_blank'>PMC11398858</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.114609' target='_blank'>10.1016/j.celrep.2024.114609</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.114609','39116210', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(18);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.celrep.2024.114609' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/10/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.celrep.2024.114609" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The NLRP3 inflammasome is dysregulated in autoinflammatory disorders caused by inherited mutations and contributes to the pathogenesis of several chronic inflammatory diseases. In this study, we discovered that disulfiram, a safe US Food and Drug Administration (FDA)-approved drug, specifically inhibits the NLRP3 inflammasome but not the NLRC4 or AIM2 inflammasomes. Disulfiram suppresses caspase-1 activation, ASC speck formation, and pyroptosis induced by several stimuli that activate NLRP3. Mechanistically, NLRP3 is palmitoylated at cysteine 126, a modification required for its localization to the trans-Golgi network and inflammasome activation, which was inhibited by disulfiram. Administration of disulfiram to animals inhibited the NLRP3, but not NLRC4, inflammasome in vivo. Our study uncovers a mechanism by which disulfiram targets NLRP3 and provides a rationale for using a safe FDA-approved drug for the treatment of NLRP3-associated inflammatory diseases. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Immunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22disulfiram%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">disulfiram</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gasdermin+D%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gasdermin D</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammasome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disulfiram%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disulfiram/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLR+Family%2c+Pyrin+Domain-Containing+3+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLR Family, Pyrin Domain-Containing 3 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammasomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammasomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoylation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoylation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22United+States+Food+and+Drug+Administration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">United States Food and Drug Administration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22United+States%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">United States</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caspase+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Caspase 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HEK293+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HEK293 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Approval%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Approval</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAID+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R37 AI063331 NIAID NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Krzystyniak A</b>, Gluchowska A, Pytyś A, Dudkowska M, Wójtowicz T, Targonska A, Janiszewska D, Sikora E, Mosieniak G. 2-Bromopalmitate treatment attenuates senescence phenotype in human adult cells - possible role of <span class="highlight-field">palmitoylation</span>. <em class='incite-journal-name' onclick='ShowInCiteJournal(168339);'>Aging (Albany NY)</em> 2024;<b>16</b>:11796-11808. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39181690' target='_blank'>39181690</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11386925' target='_blank'>PMC11386925</a> DOI: <a href='https://dx.doi.org/10.18632/aging.206080' target='_blank'>10.18632/aging.206080</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.18632/aging.206080','39181690', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.18632/aging.206080' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168339);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.18632/aging.206080" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cells may undergo senescence in response to DNA damage, which is associated with cell cycle arrest, altered gene expression and altered cell morphology. Protein palmitoylation is one of the mechanisms by which the DNA damage response is regulated. Therefore, we hypothesized that protein palmitoylation played a role in regulation of the senescent phenotype. Here, we showed that treatment of senescent human vascular smooth muscle cells (VSMCs) with 2-bromopalmitate (2-BP), an inhibitor of protein acyltransferases, is associated with changes in different aspects of the senescent phenotype, including the resumption of cell proliferation, a decrease in DNA damage markers and the downregulation of senescence-associated β-galactosidase activity. The effects were dose dependent and associated with significantly decreased total protein palmitoylation level. We also showed that the senescence-modifying properties of 2-BP were at least partially mediated by the downregulation of elements of DNA damage-related molecular pathways, such as phosphorylated p53. Our data suggest that cell senescence may be regulated by palmitoylation, which provides a new perspective on the role of this posttranslational modification in age-related diseases. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%222-BP%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2-BP</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+damage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA damage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+senescence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell senescence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22vascular+smooth+muscle+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">vascular smooth muscle cell</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellular+Senescence%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellular Senescence/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Palmitates%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Palmitates/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoylation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoylation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+Damage%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA Damage/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle%2c+Smooth%2c+Vascular%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle, Smooth, Vascular/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle%2c+Smooth%2c+Vascular%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle, Smooth, Vascular/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle%2c+Smooth%2c+Vascular%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle, Smooth, Vascular/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocytes%2c+Smooth+Muscle%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocytes, Smooth Muscle/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocytes%2c+Smooth+Muscle%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocytes, Smooth Muscle/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Suppressor+Protein+p53%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Suppressor Protein p53/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22beta-Galactosidase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">beta-Galactosidase/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Liu Y</b>, Hou D, Chen W, Lu X, Komaniecki GP, Xu Y, Yu T, Zhang SM, Linder ME, Lin H. MAVS Cys508 <span class="highlight-field">palmitoylation</span> promotes its aggregation on the mitochondrial outer membrane and antiviral innate immunity. <em class='incite-journal-name' onclick='ShowInCiteJournal(19666);'>Proc Natl Acad Sci U S A</em> 2024;<b>121</b>:e2403392121. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39141356' target='_blank'>39141356</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348129' target='_blank'>PMC11348129</a> DOI: <a href='https://dx.doi.org/10.1073/pnas.2403392121' target='_blank'>10.1073/pnas.2403392121</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1073/pnas.2403392121','39141356', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(20);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1073/pnas.2403392121' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(19666);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/15/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1073/pnas.2403392121" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cysteine palmitoylation or S-palmitoylation catalyzed by the ZDHHC family of acyltransferases regulates the biological function of numerous mammalian proteins as well as viral proteins. However, understanding of the role of S-palmitoylation in antiviral immunity against RNA viruses remains very limited. The adaptor protein MAVS forms functionally essential prion-like aggregates upon activation by viral RNA-sensing RIG-I-like receptors. Here, we identify that MAVS, a C-terminal tail-anchored mitochondrial outer membrane protein, is S-palmitoylated by ZDHHC7 at Cys508, a residue adjacent to the tail-anchor transmembrane helix. Using superresolution microscopy and other biochemical techniques, we found that the mitochondrial localization of MAVS at resting state mainly depends on its transmembrane tail-anchor, without regulation by Cys508 S-palmitoylation. However, upon viral infection, MAVS S-palmitoylation stabilizes its aggregation on the mitochondrial outer membrane and thus promotes subsequent propagation of antiviral signaling. We further show that inhibition of MAVS S-palmitoylation increases the host susceptibility to RNA virus infection, highlighting the importance of S-palmitoylation in the antiviral innate immunity. Also, our results indicate ZDHHC7 as a potential therapeutic target for MAVS-related autoimmune diseases. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAVS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAVS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ZDHHC7%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ZDHHC7</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antiviral+innate+immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antiviral innate immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tail-anchored+proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tail-anchored proteins</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondrial+Membranes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondrial Membranes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acyltransferases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acyltransferases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HEK293+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HEK293 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cysteine%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cysteine/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Aggregates%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Aggregates</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HHMI+(HHMI)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NA HHMI (HHMI)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HHS+%7c+NIH+(NIH)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01AI153110 HHS | NIH (NIH)</a></li></ul> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Tang J</b>, Liu H, Li J, Zhang Y, Yao S, Yang K, You Z, Qiao X, Song Y. Regulation of post-translational modification of PD-L1 and associated opportunities for novel small-molecule therapeutics. <em class='incite-journal-name' onclick='ShowInCiteJournal(9396);'>Future Med Chem</em> 2024;<b>16</b>:1583-1599. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38949857' target='_blank'>38949857</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370925' target='_blank'>PMC11370925</a> DOI: <a href='https://dx.doi.org/10.1080/17568919.2024.2366146' target='_blank'>10.1080/17568919.2024.2366146</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/17568919.2024.2366146','38949857', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(21);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/17568919.2024.2366146' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9396);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/05/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/02/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1080/17568919.2024.2366146" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">PD-L1 is overexpressed on the surface of tumor cells and binds to PD-1, resulting in tumor immune escape. Therapeutic strategies to target the PD-1/PD-L1 pathway involve blocking the binding. Immune checkpoint inhibitors have limited efficacy against tumors because PD-L1 is also present in the cytoplasm. PD-L1 of post-translational modifications (PTMs) have uncovered numerous mechanisms contributing to carcinogenesis and have identified potential therapeutic targets. Therefore, small molecule inhibitors can block crucial carcinogenic signaling pathways, making them a potential therapeutic option. To better develop small molecule inhibitors, we have summarized the PTMs of PD-L1. This review discusses the regulatory mechanisms of small molecule inhibitors in carcinogenesis and explore their potential applications, proposing a novel approach for tumor immunotherapy based on PD-L1 PTM. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22N-linked+glycosylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">N-linked glycosylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PD-L1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PD-L1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PTMs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PTMs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22acetylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">acetylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22methylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">methylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22phosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">phosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ubiquitination%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ubiquitination</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Processing%2c+Post-Translational%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Processing, Post-Translational/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B7-H1+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B7-H1 Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B7-H1+Antigen%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B7-H1 Antigen/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Small+Molecule+Libraries%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Small Molecule Libraries/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Small+Molecule+Libraries%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Small Molecule Libraries/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/chemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82273792, 82003597 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Hebei+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B2022201092, B2021201026 Natural Science Foundation of Hebei Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Undergraduate+Innovation+and+Entrepreneurship+Training+Program+of+Hebei+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">S202310075048 Undergraduate Innovation and Entrepreneurship Training Program of Hebei Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Science+and+Technology+Project+of+Hebei+Education+Department%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">QN2022057 Natural Science Foundation of Science and Technology Project of Hebei Education Department</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Innovation+Team+Project+of+Hebei+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IT2023C01 Innovation Team Project of Hebei University</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Interdisciplinary+Research+Program+of+Hebei+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DXK202215 Natural Science Interdisciplinary Research Program of Hebei University</a></li></ul> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Liebl K</b>, Voth GA. Lipid Organization by the Caveolin-1 Complex. <em>BIORXIV : THE PREPRINT SERVER FOR BIOLOGY</em> 2024:2024.07.10.602986. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39026816' target='_blank'>39026816</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11257593' target='_blank'>PMC11257593</a> DOI: <a href='https://dx.doi.org/10.1101/2024.07.10.602986' target='_blank'>10.1101/2024.07.10.602986</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1101/2024.07.10.602986','39026816', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(22);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1101/2024.07.10.602986' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/20/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1101/2024.07.10.602986" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Caveolins are lipid-binding proteins that can organize membrane remodeling and oligomerize into the 8S-complex. The CAV1 8S-complex comprises a disk-like structure, about 15nm in diameter, with a central beta barrel. Further oligomerization of 8S-complexes remodels the membrane into caveolae vessels, with a dependence on cholesterol concentration. However, the molecular mechanisms behind membrane remodeling and cholesterol filtering are still not understood. Performing atomistic Molecular Dynamics simulations in combination with advanced sampling techniques, we describe how the CAV1-8S complex bends the membrane and accumulates cholesterol. Here, our simulations show an enhancing effect by the palmitoylations of CAV1, and we predict that the CAV1-8S complex can extract cholesterol molecules from the lipid bilayer and accommodate them in its beta barrel. Through backmapping to the all-atom level we also conclude that the Martini v2 coarse-grained forcefield overestimates membrane bending, as the atomistic simulations exhibit only very localized bending. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caveolin-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Caveolin-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Martini+CG+simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Martini CG simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metadynamics+simulations%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metadynamics simulations</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cholesterol+accumulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cholesterol accumulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIGMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 GM063796 NIGMS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">S10 OD028655 NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Peng F</b>, Lu J, Su K, Liu X, Luo H, He B, Wang C, Zhang X, An F, Lv D, Luo Y, Su Q, Jiang T, Deng Z, He B, Xu L, Guo T, Xiang J, Gu C, Wang L, Xu G, Xu Y, Li M, Kelley KW, Cui B, Liu Q. Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis. <em class='incite-journal-name' onclick='ShowInCiteJournal(5228);'>Cell Metab</em> 2024;<b>36</b>:1598-1618.e11. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38772364' target='_blank'>38772364</a> DOI: <a href='https://dx.doi.org/10.1016/j.cmet.2024.04.018' target='_blank'>10.1016/j.cmet.2024.04.018</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.cmet.2024.04.018','38772364', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.cmet.2024.04.018' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5228);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/cell-metabolism/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/02/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/23/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.cmet.2024.04.018" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Circadian disruption predicts poor cancer prognosis, yet how circadian disruption is sensed in sleep-deficiency (SD)-enhanced tumorigenesis remains obscure. Here, we show fatty acid oxidation (FAO) as a circadian sensor relaying from clock disruption to oncogenic metabolic signal in SD-enhanced lung tumorigenesis. Both unbiased transcriptomic and metabolomic analyses reveal that FAO senses SD-induced circadian disruption, as illustrated by continuously increased palmitoyl-coenzyme A (PA-CoA) catalyzed by long-chain fatty acyl-CoA synthetase 1 (ACSL1). Mechanistically, SD-dysregulated CLOCK hypertransactivates ACSL1 to produce PA-CoA, which facilitates CLOCK-Cys194 S-palmitoylation in a ZDHHC5-dependent manner. This positive transcription-palmitoylation feedback loop prevents ubiquitin-proteasomal degradation of CLOCK, causing FAO-sensed circadian disruption to maintain SD-enhanced cancer stemness. Intriguingly, timed β-endorphin resets rhythmic Clock and Acsl1 expression to alleviate SD-enhanced tumorigenesis. Sleep quality and serum β-endorphin are negatively associated with both cancer development and CLOCK/ACSL1 expression in patients with cancer, suggesting dawn-supplemented β-endorphin as a potential chronotherapeutic strategy for SD-related cancer. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ACSL1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ACSL1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CLOCK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CLOCK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+acid+oxidation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty acid oxidation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer+stemness%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer stemness</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chronotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chronotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22circadian+rhythm%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">circadian rhythm</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sleep+deficiency%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sleep deficiency</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%ce%b2-endorphin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">β-endorphin</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Acids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Acids/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinogenesis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinogenesis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinogenesis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinogenesis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinogenesis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinogenesis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coenzyme+A+Ligases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Coenzyme A Ligases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coenzyme+A+Ligases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Coenzyme A Ligases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidation-Reduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidation-Reduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Circadian+Rhythm%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Circadian Rhythm</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CLOCK+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CLOCK Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CLOCK+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CLOCK Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sleep+Deprivation%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sleep Deprivation/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Wang SY</b>, Xia ZX, Yang SW, Chen WK, Zhao YL, Li MD, Tian D, Pan Y, Lin XS, Zhu XQ, Huang Z, Liu JM, Lai ZM, Tao WC, Shen ZC. Regulation of depressive-like behaviours by <span class="highlight-field">palmitoylation</span>: Role of AKAP150 in the basolateral amygdala. <em class='incite-journal-name' onclick='ShowInCiteJournal(4298);'>Br J Pharmacol</em> 2024;<b>181</b>:1897-1915. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38413375' target='_blank'>38413375</a> DOI: <a href='https://dx.doi.org/10.1111/bph.16318' target='_blank'>10.1111/bph.16318</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/bph.16318','38413375', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/bph.16318' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4298);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/25/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/20/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/23/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/29/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1111/bph.16318" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND AND PURPOSE</div><div class="abstract-content">Protein palmitoylation is involved in learning and memory, and in emotional disorders. Yet, the underlying mechanisms in these processes remain unclear. Herein, we describe that A-kinase anchoring protein 150 (AKAP150) is essential and sufficient for depressive-like behaviours in mice via a palmitoylation-dependent mechanism. </div><div class="abstract-label">EXPERIMENTAL APPROACH</div><div class="abstract-content">Depressive-like behaviours in mice were induced by chronic restraint stress (CRS) and chronic unpredictable mild stress (CUMS). Palmitoylated proteins in the basolateral amygdala (BLA) were assessed by an acyl-biotin exchange assay. Genetic and pharmacological approaches were used to investigate the role of the DHHC2-mediated AKAP150 palmitoylation signalling pathway in depressive-like behaviours. Electrophysiological recording, western blotting and co-immunoprecipitation were performed to define the mechanistic pathway. </div><div class="abstract-label">KEY RESULTS</div><div class="abstract-content">Chronic stress successfully induced depressive-like behaviours in mice and enhanced AKAP150 palmitoylation in the BLA, and a palmitoylation inhibitor was enough to reverse these changes. Blocking the AKAP150-PKA interaction with the peptide Ht-31 abolished the CRS-induced AKAP150 palmitoylation signalling pathway. DHHC2 expression and palmitoylation levels were both increased after chronic stress. DHHC2 knockdown prevented CRS-induced depressive-like behaviours, as well as attenuating AKAP150 signalling and synaptic transmission in the BLA in CRS-treated mice. </div><div class="abstract-label">CONCLUSION AND IMPLICATIONS</div><div class="abstract-content">These results delineate that DHHC2 modulates chronic stress-induced depressive-like behaviours and synaptic transmission in the BLA via the AKAP150 palmitoylation signalling pathway, and this pathway may be considered as a promising novel therapeutic target for major depressive disorder. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AKAP150%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AKAP150</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DHHC2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DHHC2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22basolateral+amygdala%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">basolateral amygdala</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chronic+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chronic stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22A+Kinase+Anchor+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">A Kinase Anchor Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%2fpsychology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression/psychology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basolateral+Nuclear+Complex%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Basolateral Nuclear Complex/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Psychological%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Psychological/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Behavior%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Behavior, Animal</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; 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text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Voytyuk O</b>, Ohata Y, Moustakas A, Ten Dijke P, Heldin CH. Smad7 <span class="highlight-field">palmitoylation</span> by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling. <em class='incite-journal-name' onclick='ShowInCiteJournal(12370);'>J Biol Chem</em> 2024;<b>300</b>:107462. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38876303' target='_blank'>38876303</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11277750' target='_blank'>PMC11277750</a> DOI: <a href='https://dx.doi.org/10.1016/j.jbc.2024.107462' target='_blank'>10.1016/j.jbc.2024.107462</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jbc.2024.107462','38876303', 'palmitoylation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jbc.2024.107462' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12370);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/03/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/16/2024]</span></span><span class="ref-count"> Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1016/j.jbc.2024.107462" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Intracellular signaling by the pleiotropic cytokine transforming growth factor-β (TGF-β) is inhibited by Smad7 in a feedback control mechanism. The activity of Smad7 is tightly regulated by multiple post-translational modifications. Using resin-assisted capture and metabolic labeling methods, we show here that Smad7 is S-palmitoylated in mammary epithelial cell models that are widely studied because of their strong responses to TGF-β and their biological relevance to mammary development and tumor progression. S-palmitoylation of Smad7 is mediated by zDHHC17, a member of a family of 23 S-acyltransferase enzymes. Moreover, we identified four cysteine residues (Cys202, Cys225, Cys415, and Cys417) in Smad7 as palmitoylation acceptor sites. S-palmitoylation of Smad7 on Cys415 and Cys417 promoted the translocation of Smad7 from the nucleus to the cytoplasm, enhanced the stability of the Smad7 protein, and enforced its inhibitory effect on TGF-β-induced Smad transcriptional response. Thus, our findings reveal a new post-translational modification of Smad7, and highlight an important role of S-palmitoylation to enhance inhibition of TGF-β/Smad signaling by Smad7. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Smad7%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Smad7</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TGF-%ce%b2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TGF-β</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22post-translational+modification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">post-translational modification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">signaling</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a 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},'uniqueID':'ctl00$RootHolder$pcEditArticleControl','popupAnimationType':'fade','allowResize':true,'closeAction':'CloseButton','popupHorizontalAlign':'WindowCenter','popupVerticalAlign':'WindowCenter','isPopupPositionCorrectionOn':false,'allowDragging':true,'modal':true,'width':800,'widthFromServer':true,'height':500,'defaultWindowPopupElementIDList':['popupArea'],'contentOverflowX':'Hidden','contentOverflowY':'Scroll','SSLSecureBlankUrl':'/DXR.axd?r=1_0-HCSds'}); //--> </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" 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class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">palmitoylation (401 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td> </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex',[[['dxeDisabled_MetropolisBlue'],[''],['','I']]]); ASPx.createControl(ASPxClientTextBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex','tbExportDetailStartIndex',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex'},{'TextChanged':ExportDetailStartIndex_Changed},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </td> <td> to </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="401" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex',[[['dxeDisabled_MetropolisBlue'],[''],['','I']]]); ASPx.createControl(ASPxClientTextBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex','tbExportDetailEndIndex',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex'},{'TextChanged':ExportDetailEndIndex_Changed},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </td> <td> </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L',[[['dxeDisabled_MetropolisBlue'],[''],['']]]); ASPx.createControl(ASPxClientListBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L','',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L','stateObject':{'CustomCallback':''},'isComboBoxList':true,'hasSampleItem':true,'isHasFakeRow':true,'hoverClasses':['dxeListBoxItemHover_MetropolisBlue'],'selectedClasses':['dxeListBoxItemSelected_MetropolisBlue'],'disabledClasses':['dxeDisabled_MetropolisBlue']},{'SelectedIndexChanged':function (s, e) { ASPx.CBLBSelectedIndexChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', e); },'ItemClick':function (s, e) { ASPx.CBLBItemMouseUp('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', e); }},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD',[[['dxpc-closeBtnHover'],[''],['HCB-1']]]); ASPx.createControl(ASPxClientPopupControl,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD','',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD','adjustInnerControlsSizeOnShow':false,'popupAnimationType':'slide','closeAction':'CloseButton','popupHorizontalAlign':'LeftSides','popupVerticalAlign':'Below','isPopupPositionCorrectionOn':false},{'Shown':function (s, e) { ASPx.DDBPCShown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', e); }}); //--> </script><script id="dxss_1678130197" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource',[[['dxeButtonEditButtonHover_MetropolisBlue'],[''],['B-100','B-1']]]); ASPx.AddPressedItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource',[[['dxeButtonEditButtonPressed_MetropolisBlue'],[''],['B-100','B-1']]]); ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource',[[['dxeDisabled_MetropolisBlue'],[''],['','I']],[['dxeDisabled_MetropolisBlue dxeButtonDisabled_MetropolisBlue'],[''],['B-100','B-1'],,[[{'spriteCssClass':'dxEditors_edtClearDisabled_MetropolisBlue'}],[{'spriteCssClass':'dxEditors_edtDropDownDisabled_MetropolisBlue'}]],['Img']]]); ASPx.createControl(ASPxClientComboBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource','selectDetailSource',{'callBack':function(arg) { WebForm_DoCallback('ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource',arg,ASPx.Callback,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource',ASPx.CallbackError,true); },'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource','stateObject':{'rawValue':''},'nullText':'Please Select','autoCompleteAttribute':{'name':'autocomplete','value':'off'},'clearButtonDisplayMode':'OnHover','lastSuccessValue':null,'islastSuccessValueInit':true,'allowNull':true},null,null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''},{'key':'N','className':'dxeNullText_MetropolisBlue','cssText':''}]}); //--> </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L',[[['dxeDisabled_MetropolisBlue'],[''],['']]]); ASPx.createControl(ASPxClientListBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L','',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L','stateObject':{'CustomCallback':''},'savedSelectedIndex':0,'itemsValue':[2023,2022,2021],'isComboBoxList':true,'hasSampleItem':true,'hoverClasses':['dxeListBoxItemHover_MetropolisBlue'],'selectedClasses':['dxeListBoxItemSelected_MetropolisBlue'],'disabledClasses':['dxeDisabled_MetropolisBlue']},{'SelectedIndexChanged':function (s, e) { ASPx.CBLBSelectedIndexChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', e); },'ItemClick':function (s, e) { ASPx.CBLBItemMouseUp('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', e); }},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD',[[['dxpc-closeBtnHover'],[''],['HCB-1']]]); ASPx.createControl(ASPxClientPopupControl,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD','',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD','adjustInnerControlsSizeOnShow':false,'popupAnimationType':'slide','closeAction':'CloseButton','popupHorizontalAlign':'LeftSides','popupVerticalAlign':'Below','isPopupPositionCorrectionOn':false},{'Shown':function (s, e) { ASPx.DDBPCShown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', e); }}); //--> </script><script id="dxss_2013408041" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear',[[['dxeButtonEditButtonHover_MetropolisBlue'],[''],['B-1']]]); ASPx.RemoveHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear',[[['B-100']]]); ASPx.AddPressedItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear',[[['dxeButtonEditButtonPressed_MetropolisBlue'],[''],['B-1']]]); ASPx.RemovePressedItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear',[[['B-100']]]); ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear',[[['dxeDisabled_MetropolisBlue'],[''],['','I']],[['dxeDisabled_MetropolisBlue dxeButtonDisabled_MetropolisBlue'],[''],['B-1'],,[[{'spriteCssClass':'dxEditors_edtDropDownDisabled_MetropolisBlue'}]],['Img']]]); ASPx.RemoveDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear',[[['B-100'],]]); ASPx.createControl(ASPxClientComboBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear','cbJcrYear',{'callBack':function(arg) { WebForm_DoCallback('ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear',arg,ASPx.Callback,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear',ASPx.CallbackError,true); },'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear','stateObject':{'rawValue':'2023'},'nullText':'Please Select','autoCompleteAttribute':{'name':'autocomplete','value':'off'},'lastSuccessValue':2023,'islastSuccessValueInit':true},null,null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''},{'key':'N','className':'dxeNullText_MetropolisBlue','cssText':''}]}); //--> </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L',[[['dxeDisabled_MetropolisBlue'],[''],['']]]); ASPx.createControl(ASPxClientListBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L','',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L','stateObject':{'CustomCallback':''},'itemsValue':[1,2,3,4],'isComboBoxList':true,'hasSampleItem':true,'hoverClasses':['dxeListBoxItemHover_MetropolisBlue'],'selectedClasses':['dxeListBoxItemSelected_MetropolisBlue'],'disabledClasses':['dxeDisabled_MetropolisBlue']},{'SelectedIndexChanged':function (s, e) { ASPx.CBLBSelectedIndexChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', e); },'ItemClick':function (s, e) { ASPx.CBLBItemMouseUp('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', e); }},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD',[[['dxpc-closeBtnHover'],[''],['HCB-1']]]); ASPx.createControl(ASPxClientPopupControl,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD','',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD','adjustInnerControlsSizeOnShow':false,'popupAnimationType':'slide','closeAction':'CloseButton','popupHorizontalAlign':'LeftSides','popupVerticalAlign':'Below','isPopupPositionCorrectionOn':false},{'Shown':function (s, e) { ASPx.DDBPCShown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', e); }}); //--> </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat',[[['dxeButtonEditButtonHover_MetropolisBlue'],[''],['B-1']]]); ASPx.RemoveHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat',[[['B-100']]]); ASPx.AddPressedItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat',[[['dxeButtonEditButtonPressed_MetropolisBlue'],[''],['B-1']]]); ASPx.RemovePressedItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat',[[['B-100']]]); ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat',[[['dxeDisabled_MetropolisBlue'],[''],['','I']],[['dxeDisabled_MetropolisBlue dxeButtonDisabled_MetropolisBlue'],[''],['B-1'],,[[{'spriteCssClass':'dxEditors_edtDropDownDisabled_MetropolisBlue'}]],['Img']]]); ASPx.RemoveDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat',[[['B-100'],]]); ASPx.createControl(ASPxClientComboBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat','cbDetailFileFormat',{'callBack':function(arg) { WebForm_DoCallback('ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat',arg,ASPx.Callback,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat',ASPx.CallbackError,true); },'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat','stateObject':{'rawValue':''},'validationGroup':'Detail','customValidationEnabled':true,'isValid':true,'errorText':'Invalid value','validationPatterns':[new ASPx.RequiredFieldValidationPattern('Please fill out this field')],'setFocusOnError':true,'isErrorFrameRequired':true,'display':'Dynamic','errorDisplayMode':'t','controlCellStyles':{'cssClass':'dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeNoBorderRight dxeControlsCell_MetropolisBlue','style':''},'nullText':'Please Select','autoCompleteAttribute':{'name':'autocomplete','value':'off'},'lastSuccessValue':null,'islastSuccessValueInit':true},{'SelectedIndexChanged':function(s,e){DetailFileFormatSelectedChanged();}},null,{'decorationStyles':[{'key':'I','className':'dxeInvalid_MetropolisBlue','cssText':''},{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''},{'key':'N','className':'dxeNullText_MetropolisBlue','cssText':''}]}); //--> </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields',[[['dxeDisabled_MetropolisBlue'],[''],['']]]); ASPx.createControl(ASPxClientCheckBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields','',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields','imageProperties':{'4':['dxWeb_edtCheckBoxChecked_MetropolisBlue','dxWeb_edtCheckBoxUnchecked_MetropolisBlue'],'8':['dxWeb_edtCheckBoxCheckedDisabled_MetropolisBlue','dxWeb_edtCheckBoxUncheckedDisabled_MetropolisBlue']},'icbFocusedStyle':['dxICBFocused_MetropolisBlue','']},{'CheckedChanged':function(s,e){ if (s.GetChecked()) cbListArticleFieldExportFields.SelectAll(); else cbListArticleFieldExportFields.UnselectAll(); }},null,{'decorationStyles':[]}); //--> </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3',[[[''],[''],['']]]); //--> </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7',[[[''],[''],['']]]); //--> </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11',[[[''],[''],['']]]); //--> </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15',[[[''],[''],['']]]); //--> </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19',[[[''],[''],['']]]); //--> </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23',[[[''],[''],['']]]); //--> </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27',[[[''],[''],['']]]); //--> </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28',[[[''],[''],['']]]); //--> </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29',[[[''],[''],['']]]); //--> </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields',[[['dxeDisabled_MetropolisBlue'],[''],['','RB0','RB1','RB2','RB3','RB4','RB5','RB6','RB7','RB8','RB9','RB10','RB11','RB12','RB13','RB14','RB15','RB16','RB17','RB18','RB19','RB20','RB21','RB22','RB23','RB24','RB25','RB26','RB27','RB28','RB29']]]); ASPx.createControl(ASPxClientCheckBoxList,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields','cbListArticleFieldExportFields',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields','imageProperties':{'4':['dxWeb_edtCheckBoxChecked_MetropolisBlue','dxWeb_edtCheckBoxUnchecked_MetropolisBlue'],'8':['dxWeb_edtCheckBoxCheckedDisabled_MetropolisBlue','dxWeb_edtCheckBoxUncheckedDisabled_MetropolisBlue']},'icbFocusedStyle':['dxICBFocused_MetropolisBlue',''],'initSelectedIndices':[]},null,null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}],'items':[['Author(s)','Authors',''],['Article Title','ArticleTitle',''],['Keywords','Keywords',''],['MESH Headings','MeshHeadings',''],['Journal Title','JournalName',''],['Year','Year',''],['Article Type','ArticleType',''],['Language','Language',''],['Published Date','PublishDate',''],['First 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class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink',[[['dxeDisabled_MetropolisBlue'],[''],['']]]); ASPx.createControl(ASPxClientHyperLink,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink','ExportedDetailFileLink',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportedDetailFileLink'}); //--> </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript"> <!-- ASPx.createControl(ASPxClientFormLayout,'RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout','ExportDetailPopupFormLayout',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout','alignItemCaptionsInAllGroups':true},null,null,{'items':[['','0',,,,],['','1',,,,],['SelectDetailSource','2',,,,],['SelectDetailAuthorContribution','3',false,,,],['','4',,,,],['','5',,,,],['ExportFields','6',,,,],['','7',,,,]]}); //--> </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">palmitoylation (401 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td> </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex',[[['dxeDisabled_MetropolisBlue'],[''],['','I']]]); ASPx.createControl(ASPxClientTextBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex','tbExportStartIndex',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex'},{'TextChanged':ExportStartIndex_Changed},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </td> <td> to </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="401" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex',[[['dxeDisabled_MetropolisBlue'],[''],['','I']]]); ASPx.createControl(ASPxClientTextBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex','tbExportEndIndex',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex'},{'TextChanged':ExportEndIndex_Changed},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </td> <td> </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L',[[['dxeDisabled_MetropolisBlue'],[''],['']]]); ASPx.createControl(ASPxClientListBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L','',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L','stateObject':{'CustomCallback':''},'isComboBoxList':true,'hasSampleItem':true,'isHasFakeRow':true,'hoverClasses':['dxeListBoxItemHover_MetropolisBlue'],'selectedClasses':['dxeListBoxItemSelected_MetropolisBlue'],'disabledClasses':['dxeDisabled_MetropolisBlue']},{'SelectedIndexChanged':function (s, e) { ASPx.CBLBSelectedIndexChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', e); },'ItemClick':function (s, e) { ASPx.CBLBItemMouseUp('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', e); }},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD',[[['dxpc-closeBtnHover'],[''],['HCB-1']]]); ASPx.createControl(ASPxClientPopupControl,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD','',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD','adjustInnerControlsSizeOnShow':false,'popupAnimationType':'slide','closeAction':'CloseButton','popupHorizontalAlign':'LeftSides','popupVerticalAlign':'Below','isPopupPositionCorrectionOn':false},{'Shown':function (s, e) { ASPx.DDBPCShown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', e); }}); //--> </script><script id="dxss_228619664" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource',[[['dxeButtonEditButtonHover_MetropolisBlue'],[''],['B-100','B-1']]]); ASPx.AddPressedItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource',[[['dxeButtonEditButtonPressed_MetropolisBlue'],[''],['B-100','B-1']]]); ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource',[[['dxeDisabled_MetropolisBlue'],[''],['','I']],[['dxeDisabled_MetropolisBlue dxeButtonDisabled_MetropolisBlue'],[''],['B-100','B-1'],,[[{'spriteCssClass':'dxEditors_edtClearDisabled_MetropolisBlue'}],[{'spriteCssClass':'dxEditors_edtDropDownDisabled_MetropolisBlue'}]],['Img']]]); ASPx.createControl(ASPxClientComboBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource','selectSource',{'callBack':function(arg) { WebForm_DoCallback('ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource',arg,ASPx.Callback,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource',ASPx.CallbackError,true); },'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource','stateObject':{'rawValue':''},'nullText':'Please Select','autoCompleteAttribute':{'name':'autocomplete','value':'off'},'clearButtonDisplayMode':'OnHover','lastSuccessValue':null,'islastSuccessValueInit':true,'allowNull':true},null,null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''},{'key':'N','className':'dxeNullText_MetropolisBlue','cssText':''}]}); //--> </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L',[[['dxeDisabled_MetropolisBlue'],[''],['']]]); ASPx.createControl(ASPxClientListBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L','',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L','stateObject':{'CustomCallback':''},'savedSelectedIndex':0,'itemsValue':[1,2,3,4],'isComboBoxList':true,'hasSampleItem':true,'hoverClasses':['dxeListBoxItemHover_MetropolisBlue'],'selectedClasses':['dxeListBoxItemSelected_MetropolisBlue'],'disabledClasses':['dxeDisabled_MetropolisBlue']},{'SelectedIndexChanged':function (s, e) { ASPx.CBLBSelectedIndexChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', e); },'ItemClick':function (s, e) { ASPx.CBLBItemMouseUp('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', e); }},null,{'decorationStyles':[{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''}]}); //--> </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD',[[['dxpc-closeBtnHover'],[''],['HCB-1']]]); ASPx.createControl(ASPxClientPopupControl,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD','',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD','adjustInnerControlsSizeOnShow':false,'popupAnimationType':'slide','closeAction':'CloseButton','popupHorizontalAlign':'LeftSides','popupVerticalAlign':'Below','isPopupPositionCorrectionOn':false},{'Shown':function (s, e) { ASPx.DDBPCShown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', e); }}); //--> </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat',[[['dxeButtonEditButtonHover_MetropolisBlue'],[''],['B-1']]]); ASPx.RemoveHoverItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat',[[['B-100']]]); ASPx.AddPressedItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat',[[['dxeButtonEditButtonPressed_MetropolisBlue'],[''],['B-1']]]); ASPx.RemovePressedItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat',[[['B-100']]]); ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat',[[['dxeDisabled_MetropolisBlue'],[''],['','I']],[['dxeDisabled_MetropolisBlue dxeButtonDisabled_MetropolisBlue'],[''],['B-1'],,[[{'spriteCssClass':'dxEditors_edtDropDownDisabled_MetropolisBlue'}]],['Img']]]); ASPx.RemoveDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat',[[['B-100'],]]); ASPx.createControl(ASPxClientComboBox,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat','cbFileFormat',{'callBack':function(arg) { WebForm_DoCallback('ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat',arg,ASPx.Callback,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat',ASPx.CallbackError,true); },'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat','stateObject':{'rawValue':'Excel'},'validationGroup':'CA','customValidationEnabled':true,'isValid':true,'errorText':'Invalid value','validationPatterns':[new ASPx.RequiredFieldValidationPattern('Please fill out this field')],'setFocusOnError':true,'isErrorFrameRequired':true,'display':'Dynamic','errorDisplayMode':'t','controlCellStyles':{'cssClass':'dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeNoBorderRight dxeControlsCell_MetropolisBlue','style':''},'nullText':'Please Select','autoCompleteAttribute':{'name':'autocomplete','value':'off'},'lastSuccessValue':1,'islastSuccessValueInit':true},{'SelectedIndexChanged':function(s,e){FileFormatSelectedChanged();}},null,{'decorationStyles':[{'key':'I','className':'dxeInvalid_MetropolisBlue','cssText':''},{'key':'F','className':'dxeFocused_MetropolisBlue','cssText':''},{'key':'N','className':'dxeNullText_MetropolisBlue','cssText':''}]}); //--> </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript"> <!-- ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink',[[['dxeDisabled_MetropolisBlue'],[''],['']]]); ASPx.createControl(ASPxClientHyperLink,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink','ExportedFileLink',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportedFileLink'}); //--> </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript"> <!-- ASPx.createControl(ASPxClientFormLayout,'RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout','ExportPopupFormLayout',{'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout','alignItemCaptionsInAllGroups':true},null,null,{'items':[['','0',,,,],['','1',,,,],['SelectSource','2',,,,],['SelectAuthorContrib','3',false,,,],['','4',,,,],['','5',,,,]]}); //--> </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_ExportFilePageControl',[[['dxtc-tabHover',''],['',''],['T0','T1'],['','T']],[['dxtc-activeTabHover',''],['',''],['AT0','AT1'],['','T']]]); ASPx.AddDisabledItems('RootHolder_articleExportPopup_ExportFilePageControl',[[['dxtcLiteDisabled_MetropolisBlue',''],['',''],['T0','AT0','T1','AT1'],['','T']]]); ASPx.createControl(ASPxClientPageControl,'RootHolder_articleExportPopup_ExportFilePageControl','ExportFilePageControl',{'callBack':function(arg) { WebForm_DoCallback('ctl00$RootHolder$articleExportPopup$ExportFilePageControl',arg,ASPx.Callback,'RootHolder_articleExportPopup_ExportFilePageControl',ASPx.CallbackError,true); },'uniqueID':'ctl00$RootHolder$articleExportPopup$ExportFilePageControl','emptyHeight':true,'flexEnabled':false},null,null,{'tabs':[['Detail',,,,,],['CA',,,,,]]}); //--> </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_TPCFm1_btnExportArticles',[[['dxbButtonHover_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddPressedItems('RootHolder_articleExportPopup_TPCFm1_btnExportArticles',[[['dxbButtonPressed_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddDisabledItems('RootHolder_articleExportPopup_TPCFm1_btnExportArticles',[[['dxbDisabled_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddSelectedItems('RootHolder_articleExportPopup_TPCFm1_btnExportArticles',[[['dxbf'],[''],['CD']]]); ASPx.createControl(ASPxClientButton,'RootHolder_articleExportPopup_TPCFm1_btnExportArticles','btnExportArticles',{'uniqueID':'ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles','causesValidation':false},{'Click': function(s, e) { ExportArticles(); }}); //--> </script> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup_TPCFm1_btnCancel',[[['dxbButtonHover_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddPressedItems('RootHolder_articleExportPopup_TPCFm1_btnCancel',[[['dxbButtonPressed_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddDisabledItems('RootHolder_articleExportPopup_TPCFm1_btnCancel',[[['dxbDisabled_MetropolisBlue'],[''],[''],['','TC']]]); ASPx.AddSelectedItems('RootHolder_articleExportPopup_TPCFm1_btnCancel',[[['dxbf'],[''],['CD']]]); ASPx.createControl(ASPxClientButton,'RootHolder_articleExportPopup_TPCFm1_btnCancel','btnCancel',{'uniqueID':'ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel'},{'Click': function(s, e) { articleExportPopup.Hide(); }}); //--> </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript"> <!-- ASPx.AddHoverItems('RootHolder_articleExportPopup',[[['dxpc-closeBtnHover'],[''],['HCB-1']],[['dxpc-maximizeBtnHover'],[''],['HMXB-1']]]); ASPx.AddSelectedItems('RootHolder_articleExportPopup',[[['dxpc-maximizeBtnChecked'],[''],['HMXB-1']]]); ASPx.createControl(ASPxClientPopupControl,'RootHolder_articleExportPopup','articleExportPopup',{'callBack':function(arg) { WebForm_DoCallback('ctl00$RootHolder$articleExportPopup',arg,ASPx.Callback,'RootHolder_articleExportPopup',ASPx.CallbackError,true); },'uniqueID':'ctl00$RootHolder$articleExportPopup','popupAnimationType':'fade','allowResize':true,'closeAction':'CloseButton','popupHorizontalAlign':'WindowCenter','popupVerticalAlign':'WindowCenter','isPopupPositionCorrectionOn':false,'allowDragging':true,'modal':true,'width':800,'widthFromServer':true,'height':280,'defaultWindowPopupElementIDList':['popupArea'],'SSLSecureBlankUrl':'/DXR.axd?r=1_0-HCSds'},{'PopUp':ExportDetail_Popup}); //--> </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript"> <!-- ASPx.AddHoverItems('categorySelectorPopup',[[['dxpc-closeBtnHover'],[''],['HCB-1']]]); ASPx.createControl(ASPxClientPopupControl,'categorySelectorPopup','',{'callBack':function(arg) { WebForm_DoCallback('ctl00$categorySelectorPopup',arg,ASPx.Callback,'categorySelectorPopup',ASPx.CallbackError,true); },'uniqueID':'ctl00$categorySelectorPopup','popupAnimationType':'fade','allowResize':true,'closeAction':'CloseButton','popupHorizontalAlign':'WindowCenter','popupVerticalAlign':'WindowCenter','isPopupPositionCorrectionOn':false,'allowDragging':true,'modal':true,'width':800,'widthFromServer':true,'height':500,'defaultWindowPopupElementIDList':['popupArea'],'contentUrl':'/CategorySelector','SSLSecureBlankUrl':'/DXR.axd?r=1_0-HCSds'},{'Shown':function(s,e){onPopUpShow(s,'1','', 0.7);}}); //--> </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript"> <!-- ASPx.AddHoverItems('pcLoginPopUp',[[['dxpc-closeBtnHover'],[''],['HCB-1']]]); ASPx.createControl(ASPxClientPopupControl,'pcLoginPopUp','',{'callBack':function(arg) { WebForm_DoCallback('ctl00$pcLoginPopUp',arg,ASPx.Callback,'pcLoginPopUp',ASPx.CallbackError,true); },'uniqueID':'ctl00$pcLoginPopUp','popupAnimationType':'fade','allowResize':true,'closeAction':'CloseButton','popupHorizontalAlign':'WindowCenter','popupVerticalAlign':'WindowCenter','isPopupPositionCorrectionOn':false,'allowDragging':true,'modal':true,'width':700,'widthFromServer':true,'height':500,'defaultWindowPopupElementIDList':['popupArea'],'contentUrl':'/Login','SSLSecureBlankUrl':'/DXR.axd?r=1_0-HCSds'},{'Shown':function(s,e){onLoginPopupShow(s);}}); //--> </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript"> <!-- ASPx.AddHoverItems('aiComputePopup',[[['dxpc-closeBtnHover'],[''],['HCB-1']]]); ASPx.createControl(ASPxClientPopupControl,'aiComputePopup','',{'callBack':function(arg) { WebForm_DoCallback('ctl00$aiComputePopup',arg,ASPx.Callback,'aiComputePopup',ASPx.CallbackError,true); },'uniqueID':'ctl00$aiComputePopup','popupAnimationType':'slide','popupHorizontalAlign':'RightSides','popupVerticalAlign':'Below','isPopupPositionCorrectionOn':false,'width':300,'widthFromServer':true,'height':200,'defaultWindowPopupElementIDList':['showAICompute'],'SSLSecureBlankUrl':'/DXR.axd?r=1_0-HCSds'}); //--> </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>