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Aquaporin-5 facilitates liver regeneration following hepatectomy via ROS/<span class="highlight-field">GSDMD</span> pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(5348);'>Cell Signal</em> 2025;<b>127</b>:111602. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39814248' target='_blank'>39814248</a> DOI: <a href='https://dx.doi.org/10.1016/j.cellsig.2025.111602' target='_blank'>10.1016/j.cellsig.2025.111602</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.cellsig.2025.111602','39814248', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.cellsig.2025.111602' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5348);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/01/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/09/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/18/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.cellsig.2025.111602" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">During the proliferative phase of liver regeneration, insufficient regulation of hepatocyte hydrogen peroxide (H2O2) overproduction can result in oxidative stress and hepatocyte death. This study aims to investigate the influence of Aquaporin 5 (Aqp5) on liver regeneration by evaluating its role in reactive oxygen species (ROS) generation and NLRP3-GSDMD-mediated pyroptosis. A 70 % partial hepatectomy (PHx) model was established in Aqp5-/- mice to evaluate the pathological changes in the liver. Reactive oxygen species (ROS) production was assessed using a dichlorodihydrofluorescein diacetate (DCFH-DA) assay. Aqp5 deficiency significantly increased ROS production, the number of TUNEL-positive cells, and disrupted mitochondrial membrane potential in the liver of Aqp5-deficient mice. The impact of Aqp5 on ROS/NLRP3/Gasdermin-D (GSDMD)-mediated pyroptosis was examined through the administration of N-acetyl-L-cysteine (NAC, an ROS scavenger) or disulfiram (DSF, a GSDMD inhibitor). In Aqp5-deficient mice, the regenerative liver exhibited increased expression of NLRP3, enhanced activation of caspase-1 and GSDMD, as well as elevated secretion of IL-1β. Treatment with DSF significantly attenuated GSDMD-mediated pyroptosis triggered by Aqp5 deficiency in the regenerating liver. Furthermore, the administration of NAC to Aqp5-deficient mice resulted in a reduction in the expression levels of NLRP3, the activity levels of caspase-1 and GSDMD, as well as the release of IL-1β. Our findings indicate that the deficiency of Aqp5 facilitates GSDMD activation through the production of ROS. The suppression of ROS or inhibition of GSDMD significantly alleviates the damage and pyroptosis observed in Aqp5-deficient regenerative liver. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aqp5%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aqp5</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aquaporin+5%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aquaporin 5/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aquaporin+5%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aquaporin 5/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLR+Family%2c+Pyrin+Domain-Containing+3+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLR Family, Pyrin Domain-Containing 3 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gasdermins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gasdermins</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Yao Y</b>, Chen Y, Yao T, Li C, Li S, Wang N. Anticancer effects of OSW-1 on colorectal cancer cells via the ROS/NLRP3/Caspase-1 pyroptosis signaling pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2025;<b>148</b>:114054. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39823797' target='_blank'>39823797</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2025.114054' target='_blank'>10.1016/j.intimp.2025.114054</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2025.114054','39823797', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.intimp.2025.114054' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/06/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/20/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.intimp.2025.114054" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pyroptosis, a form of programmed cell death, has recently emerged as a compelling molecular mechanism associated with the efficacy of chemotherapeutic drugs in tumor treatment. OSW-1, derived from the bulbs of Ornithogalum saundersiae Baker, exhibits a diverse range of pharmacological effects. However, its specific antitumor effects on colorectal cancer (CRC) and the mechanisms underlying these effects remain elusive. In this study, we explored whether OSW-1 can induce pyroptosis in CRC cells, aiming to expand its potential clinical applications. Various functional experiments, including Cell Counting Kit-8 (CCK-8), plate colony formation, wound healing, and Transwell assays, were conducted to assess cell proliferation, migration, and invasion. The results of in vitro experiments revealed apparent inhibitory effects of OSW-1 on CRC cells, and we observed a pyroptosis-like morphology in treated cells by scanning electron microscopy (SEM). OSW-1 was found to induce pyroptosis through the NOD-like receptor thermal protein domain associated protein 3 (NLRP3)/cysteinyl aspartate specific proteinase-1 (Caspase-1) pathway, with the production of reactive oxygen species (ROS) mediating this pyroptotic pathway. The results from xenograft animal models further demonstrated that OSW-1 facilitated pyroptosis in CRC cells, significantly inhibiting tumor growth. In summary, our findings suggest that OSW-1 activates pyroptosis in CRC cells through the ROS/NLRP3/Caspase-1 pathway. These results provide valuable evidence regarding the role of pyroptosis in various tumor types, emphasizing the potential of OSW-1 as a therapeutic agent in tumor treatment. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antitumor+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antitumor effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ornithogalum+saundersiae%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ornithogalum saundersiae</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLR+Family%2c+Pyrin+Domain-Containing+3+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLR Family, Pyrin Domain-Containing 3 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caspase+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Caspase 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xenograft+Model+Antitumor+Assays%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xenograft Model Antitumor Assays</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Nude%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Nude</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+BALB+C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred BALB C</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Movement%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Movement/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Liu D</b>, Liu Y, Cen R. Identification of TMEM71 as a hub NLRP3-related gene suppressing malignant behavior in nasopharyngeal carcinoma via the NLRP3/Caspase-1/<span class="highlight-field">GSDMD</span> signaling pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(4180);'>Braz J Otorhinolaryngol</em> 2025;<b>91</b>:101566. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39951856' target='_blank'>39951856</a> DOI: <a href='https://dx.doi.org/10.1016/j.bjorl.2025.101566' target='_blank'>10.1016/j.bjorl.2025.101566</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bjorl.2025.101566','39951856', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.bjorl.2025.101566' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4180);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/08/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/17/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.bjorl.2025.101566" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">NLRP3 plays a key role in cellular pyroptosis and tumor progression. However, research on NLRP3-Related Genes (NRGs) in Nasopharyngeal Carcinoma (NPC) is limited. </div><div class="abstract-label">METHODS</div><div class="abstract-content">We analyzed the GSE53819 dataset to identify genes positively correlated with NLRP3 mRNA and downregulated in NPC tumors, termed NRGs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used to characterize their biological functions. Validation was performed using the GSE64634 and GSE102349 datasets. The GSE102349 dataset was used to evaluate the impact of NRGs on the Progression-Free Survival (PFS) and their association with immune cell infiltration. A cohort of 421 NPC patients from a local hospital underwent multivariate Cox regression to assess the prognostic significance of hub NRGs. Cellular experiments further investigated the role of hub NRGs in NPC. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">In the GSE53819 dataset, 26 NRGs were identified, correlated with NLRP3 expression, and downregulated in tumor tissues. GO and KEGG analyses linked these 26 NRGs to the inflammasome complex. TMEM71, identified in the GSE64634 and GSE102349 datasets, was downregulated in tumor tissues and positively correlated with NLRP3 expression. It was the only NRG with prognostic value, with higher expression correlating with improved PFS. Immune cell infiltration analysis showed significant differences between high and low TMEM71 expression groups (e.g., naïve B cells). Local analysis confirmed that positive TMEM71 expression in tumor serves as an independent prognostic marker for NPC (HR = 0.53, 95% CI 0.366‒0.780). in vitro, TMEM71 activation of the NLRP3/caspase-1/GSDMD pathway suppressed malignant behaviors in NPC cell. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">TMEM71 may serve as a prognostic biomarker for NPC and influence immune cell infiltration. Its overexpression could exert anticancer effects via the NLRP3/caspase-1/GSDMD pathway, highlight its potential as a therapeutic target in NPC. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caspase-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Caspase-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nasopharyngeal+carcinoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nasopharyngeal carcinoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TMEM71%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TMEM71</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Eskander G</b>, Abdelhamid SG, Wahdan SA, Radwan SM. Roflumilast attenuates doxorubicin and cyclophosphamide combination-induced chemobrain in rats through modulation of NLRP3/ASC/caspase-1/<span class="highlight-field">GSDMD</span> axis. <em class='incite-journal-name' onclick='ShowInCiteJournal(16199);'>Life Sci</em> 2025;<b>362</b>:123378. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39788415' target='_blank'>39788415</a> DOI: <a href='https://dx.doi.org/10.1016/j.lfs.2025.123378' target='_blank'>10.1016/j.lfs.2025.123378</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.lfs.2025.123378','39788415', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.lfs.2025.123378' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16199);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/06/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/06/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/12/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.lfs.2025.123378" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">AIM</div><div class="abstract-content">The aim of this study is to investigate the neuroprotective effect of roflumilast, a phosphodiesterase-4 (PDE-4) inhibitor on cognitive impairment induced by doxorubicin (DOX)/cyclophosphamide (CP) combination therapy and to elucidate its modulatory effect on the pyroptosis pathway. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Rats were allocated into five groups: a control group, a DOX/CP-intoxicated group, two groups receiving DOX/CP plus low-dose (0.5 mg/kg/day) or high-dose (1 mg/kg/day) roflumilast, and a roflumilast-only group. Behavioral assessments and brain tissue analyses were conducted, including histopathological staining and the measurement of inflammatory and oxidative stress markers. </div><div class="abstract-label">FINDINGS</div><div class="abstract-content">DOX/CP treatment resulted in cognitive impairment, abnormal brain histology. It significantly elevated the levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and malondialdehyde (MDA). Concurrently, superoxide dismutase (SOD) activity was reduced. Pyroptosis-associated markers, including nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3), apoptosis-associated speck-like protein (ASC), caspase-1, gasdermin-D (GSDMD), and interleukin-18 (IL-18) were upregulated. Apoptotic marker caspase-3 also exhibited increased expression. Conversely, administration of roflumilast (1 mg/kg/day) for four weeks ameliorated these pathological changes. Roflumilast improved cognitive function, reduced oxidative stress, and modulated inflammatory signaling. Additionally, it suppressed pyroptotic and apoptotic pathways within hippocampal tissue. </div><div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">These results suggest that roflumilast exerts neuroprotective effects against chemotherapy-induced cognitive dysfunction and neurodegeneration through inhibition of the NLRP3/ASC/caspase-1/GSDMD pyroptosis pathway. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemobrain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemobrain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cyclophosphamide+and+doxorubicin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cyclophosphamide and doxorubicin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Roflumilast%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Roflumilast</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cyclopropanes%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cyclopropanes/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cyclopropanes%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cyclopropanes/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aminopyridines%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aminopyridines/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Doxorubicin%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Doxorubicin/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cyclophosphamide%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cyclophosphamide/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLR+Family%2c+Pyrin+Domain-Containing+3+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLR Family, Pyrin Domain-Containing 3 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Benzamides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Benzamides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caspase+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Caspase 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphodiesterase+4+Inhibitors%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphodiesterase 4 Inhibitors/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemotherapy-Related+Cognitive+Impairment%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemotherapy-Related Cognitive Impairment/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemotherapy-Related+Cognitive+Impairment%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemotherapy-Related Cognitive Impairment/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemotherapy-Related+Cognitive+Impairment%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemotherapy-Related Cognitive Impairment/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroprotective+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroprotective Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Zeng X</b>, Wu T, Xu Q, Li L, Yuan Y, Zhu M, Liu W, Fu F, Wu Z, Yao H, Liao G, Lu Y, Cheng J, Liu J, Shi Y, Chen Y. Inhibition of IRE-1α Alleviates Pyroptosis and Metabolic Dysfunction-Associated Steatohepatitis by Suppressing Gasdermin D. <em class='incite-journal-name' onclick='ShowInCiteJournal(16095);'>Liver Int</em> 2025;<b>45</b>:e16234. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39777841' target='_blank'>39777841</a> DOI: <a href='https://dx.doi.org/10.1111/liv.16234' target='_blank'>10.1111/liv.16234</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/liv.16234','39777841', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(5);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1111/liv.16234' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16095);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/liverint' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/30/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1111/liv.16234" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVES</div><div class="abstract-content">Metabolic dysfunction-associated steatohepatitis (MASH) is a significant risk factor for cirrhosis and hepatocellular carcinoma, for which there is currently no effective treatment. This study aimed to investigate the regulatory mechanism between endoplasmic reticulum stress (ER stress) and pyroptosis in the liver under the context of MASH. </div><div class="abstract-label">METHODS AND RESULTS</div><div class="abstract-content">Pyroptosis was examined in both in vivo and in vitro ER stress models. The expression levels of nucleotide-binding oligomerisation domain-like receptor protein 3 (NLRP3), gasdermin D (GSDMD), caspase-1, IL-1β, and IL-18 tended to increase, and "ASC specks" colocalised with the swollen ER in living cells. However, in the pyroptotic model, increased ER stress was not observed. Moreover, the overexpression of inositol-requiring enzyme 1α (IRE-1α), one of the main ER stress sensors, led to increases in the levels of NLRP3 and GSDMD. However, after IRE-1α was blocked by chemical inhibitors or siRNAs, pyroptosis was also abrogated. These data showed that ER stress regulated pyroptosis through IRE-1α. Furthermore, the immunoprecipitation results clearly indicated that GSDMD efficiently bound to IRE-1α when ER stress was stimulated. In the MASH model, IRE-1α was specifically inhibited by pharmacological or genetic methods, which improved the pathology of MASH by alleviating ER stress and pyroptosis. In patients with MASH, both ER stress markers and pyroptosis markers including IRE-1α, glucose-regulated protein 78, GSDMD/GSDMD-N, p20, and NLRP3, are highly expressed in the liver. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">This study revealed that ER stress may regulate pyroptosis through IRE-1α-GSDMD pathway, which accelerates the progression of MASH. These findings may offer new insights for the treatment of MASH. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ER+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ER stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IRE%e2%80%901%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IRE‐1α</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MASH%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MASH</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pyroptosis</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endoplasmic+Reticulum+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endoplasmic Reticulum Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endoribonucleases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+1.3.5+project+for+disciplines+of+excellence%2c+West+China+Hospital%2c+Sichuan+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">(Chengdu,China,ZYGD18014) the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+and+Technology+Department+of+Sichuan+Province+project+funding%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">(2021YFH0061) Science and Technology Department of Sichuan Province project funding</a></li></ul> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Pei X</b>, Ma S, Hong L, Zuo Z, Xu G, Chen C, Shen Y, Liu D, Li C, Li D. Molecular insights of T-2 toxin exposure-induced neurotoxicity and the neuroprotective effect of dimethyl fumarate. <em class='incite-journal-name' onclick='ShowInCiteJournal(169671);'>Food Chem Toxicol</em> 2025;<b>196</b>:115166. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39617286' target='_blank'>39617286</a> DOI: <a href='https://dx.doi.org/10.1016/j.fct.2024.115166' target='_blank'>10.1016/j.fct.2024.115166</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.fct.2024.115166','39617286', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.fct.2024.115166' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169671);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.fct.2024.115166" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">T-2 toxin, a potent environmental pollutant, has been proved to stimulate neuroinflammation, while the connection between T-2 toxin and pyroptosis remain elusive. Dimethyl fumarate (DMF), recently identified as a neuroprotectant and pyroptosis inhibitor, has potential therapeutic applications that are underexplored. Based on present study in vitro and vivo, we demonstrated that T-2 toxin induced the activation of NLRP3-Caspase-1 inflammasome in hippocampal neurons. In addition to proinflammatory mediator overexpression, gasdermin D (GSDMD)-dependently pyroptosis in the mouse hippocampal neuron cell line (HT22) treated by T-2 toxin was determined in our study. Moreover, the palliative effect of knockdown sequence of high mobility group B1 protein (HMGB1) provided more details for T-2 toxin-initiated pyroptosis. Importantly, we confirmed that DMF, as a novel inhibitor of GSDMD, could alleviate pyroptosis induced by T-2 toxin in an GSDMD targeting manner. In summary, our studies exposed the evidence that T-2 toxin could induce NLRP3 inflammasome activation and hippocampal neuronal pyroptosis. More notably, DMF was turn out to be a critical executioner for attenuating GSDMD-mediated pyroptosis. Our data found a new function of DMF and suggested a novel therapy strategy against mycotoxin-triggered neuronal inflammation, which leads to varieties of neurological diseases. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dimethyl+fumarate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dimethyl fumarate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammasome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-2+toxin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-2 toxin</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dimethyl+Fumarate%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dimethyl Fumarate/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroprotective+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroprotective Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a 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Macrophage Dvl2 deficiency promotes NOD1-Driven pyroptosis and exacerbates inflammatory liver injury. <em class='incite-journal-name' onclick='ShowInCiteJournal(20161);'>Redox Biol</em> 2025;<b>79</b>:103455. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39644526' target='_blank'>39644526</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667066' target='_blank'>PMC11667066</a> DOI: <a href='https://dx.doi.org/10.1016/j.redox.2024.103455' target='_blank'>10.1016/j.redox.2024.103455</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.redox.2024.103455','39644526', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.redox.2024.103455' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20161);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/09/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.redox.2024.103455" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Dishevelled 2 (Dvl2) is a key mediator of the Wingless/Wnt signaling pathway that regulates cell proliferation, migration, and immune function. However, little is known about the role of macrophage Dvl2 in modulating NOD1-mediated pyroptosis and hepatocyte death in oxidative stress-induced inflammatory liver injury. In a mouse model of oxidative stress-induced liver inflammation, mice with myeloid-specific Dvl2 knockout (Dvl2M-KO) displayed exacerbated ischemia/reperfusion (IR) stress-induced hepatocellular damage with increased serum ALT levels, oxidative stress, and proinflammatory mediators. Unlike in Dvl2FL/FL controls, Dvl2M-KO enhanced NOD1, caspase-1, GSDMD, and NF-κB activation in liver macrophages after IR. Interestingly, IR stress enhanced YAP colocalized with HSF1 in Dvl2FL/FL macrophages, while macrophage Dvl2 deficiency reduced YAP and HSF1 colocalization in the nucleus under inflammatory conditions. Importantly, Dvl2 deletion diminished nuclear YAP interacted with HSF1 and augmented NOD1/caspase-1 and GSDMD activation in response to inflammatory stimulation. However, Dvl2 activation increased YAP interaction with HSF1 and activated HSF1 target gene eEF2, inhibiting NOD1/caspase-1, GSDMD, and NF-κB activity. Moreover, macrophage eEF2 deletion increased the NOD1-caspase-1 interaction, GSDMD activation, HMGB1 release, and hepatocyte LDH release after macrophage/hepatocyte co-culture. Adoptive transfer of eEF2-expressing macrophages in Dvl2M-KO mice alleviated IR-triggered liver inflammation and hepatocellular damage. Therefore, macrophage Dvl2 deficiency promotes NOD1-mediated pyroptosis and exacerbates IR-induced hepatocellular death by disrupting the YAP-HSF1 axis. eEF2 is crucial for modulating NOD1-driven pyroptosis, inflammatory response, and hepatocyte death. Our findings underscore a novel role of macrophage Dvl2 in modulating liver inflammatory injury and imply the therapeutic potential in organ IRI and transplant recipients. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HSF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HSF1</a></li><li><a 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Bai X, Yue J, Wang X, Yuan P, Qian H. The N6-methyladenosine writer METTL3 promotes breast cancer progression through YTHDF2-dependent posttranscriptional silencing of <span class="highlight-field">GSDMD</span>. <em class='incite-journal-name' onclick='ShowInCiteJournal(2443);'>Apoptosis</em> 2025;<b>30</b>:226-238. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39627574' target='_blank'>39627574</a> DOI: <a href='https://dx.doi.org/10.1007/s10495-024-02037-1' target='_blank'>10.1007/s10495-024-02037-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s10495-024-02037-1','39627574', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1007/s10495-024-02037-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(2443);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/06/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1007/s10495-024-02037-1" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cell pyroptosis is a form of programmed cell death, with Gasdermin-D (GSDMD) acting as its key executor. While activating pyroptosis represents a promising therapeutic strategy for cancer, the regulatory mechanisms governing GSDMD expression during cell death remain poorly understood. In this study, we identified METTL3 as a negative regulator of GSDMD-mediated pyroptosis, with high expression in breast cancer (BC) cells. YTHDF2 was found to recognize the m6A modification of GSDMD, thereby decreasing its stability. Finally, in vivo experiments further demonstrated the inhibitory effect of the METTL3 inhibitor STM2457 on tumors. Overall, these findings suggest that inhibition of METTL3 can enhance GSDMD-mediated pyroptosis and reveal a novel regulatory mechanism governing GSDMD expression, presenting a novel strategy for cancer treatment. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22METTL3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">METTL3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22N6-methyladenosine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">N6-methyladenosine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22YTHDF2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">YTHDF2</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA-Binding+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA-Binding Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methyltransferases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methyltransferases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methyltransferases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methyltransferases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adenosine%2fanalogs+%26amp%3b+derivatives%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adenosine/analogs & derivatives</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adenosine%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adenosine/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Progression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Nude%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Nude</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAMS+Innovation+Fund+for+Medical+Sciences%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2023-I2M-2-004 CAMS Innovation Fund for Medical Sciences</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82172650 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Beijing+Natural+Science+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">7222150 Beijing Natural Science Foundation</a></li></ul> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Ehrens A</b>, Lenz B, Nieto-Pérez C, Latz E, Schmidt FI, Hoerauf A, Hübner MP. Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115164. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39772394' target='_blank'>39772394</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115164' target='_blank'>10.1016/j.celrep.2024.115164</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115164','39772394', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115164' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/11/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.celrep.2024.115164" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Granulocytes exert several effector mechanisms, including the release of DNA traps during ETosis. While bacteria-induced ETosis has been linked to the non-canonical inflammasome pathway, the role of the inflammasome activation during ETosis in response to extracellular pathogens has not been investigated. The current study demonstrates that microfilariae (MF) of the rodent filarial nematode Litomosoides sigmodontis induce eosinophil ETosis via the canonical inflammasome pathway. The absence of key components of the canonical inflammasome, including gasdermin D, caspase-1, the adaptor molecule ASC, or AIM2 (double-stranded DNA sensor) prevents MF-induced DNA release in murine eosinophils. While AIM2 activation is not affecting other effector mechanisms such as reactive oxygen species generation and nuclear membrane collapse, it appears to be critical in mediating the release of DNA from the cell during the later stages of ETosis. Finally, the findings on inflammasome-dependent ETosis in response to MF are confirmed in human eosinophils. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AIM2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AIM2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Immunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Microbiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ETosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ETosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caspase-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">caspase-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22eosinophils%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">eosinophils</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22filariae%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">filariae</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammasome</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammasomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammasomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Filarioidea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Filarioidea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microfilariae%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microfilariae</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eosinophils%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eosinophils/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eosinophils%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eosinophils/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Filariasis%2fparasitology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Filariasis/parasitology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Filariasis%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Filariasis/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caspase+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Caspase 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Traps%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Traps/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gasdermins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gasdermins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA-Binding+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA-Binding Proteins</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Wright SS</b>, Kumari P, Fraile-Ágreda V, Wang C, Shivcharan S, Kappelhoff S, Margheritis EG, Matz A, Vasudevan SO, Rubio I, Bauer M, Zhou B, Vanaja SK, Cosentino K, Ruan J, Rathinam VA. Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(4693);'>Cell</em> 2025;<b>188</b>:280-291.e17. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39742811' target='_blank'>39742811</a> DOI: <a href='https://dx.doi.org/10.1016/j.cell.2024.11.018' target='_blank'>10.1016/j.cell.2024.11.018</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.cell.2024.11.018','39742811', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.cell.2024.11.018' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4693);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/04/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.cell.2024.11.018" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pyroptosis mediated by gasdermins (GSDMs) plays crucial roles in infection and inflammation. Pyroptosis triggers the release of inflammatory molecules, including damage-associated molecular patterns (DAMPs). However, the consequences of pyroptosis-especially beyond interleukin (IL)-1 cytokines and DAMPs-that govern inflammation are poorly defined. Here, we show intercellular propagation of pyroptosis from dying cells to bystander cells in vitro and in vivo. We identified extracellular vesicles (EVs) released by pyroptotic cells as the propagator of lytic death to naive cells, promoting inflammation. DNA-PAINT super-resolution and immunoelectron microscopy revealed GSDMD pore structures on EVs released by pyroptotic cells. Importantly, pyroptotic EVs transplant GSDMD pores on the plasma membrane of bystander cells and kill them. Overall, we demonstrate that cell-to-cell vesicular transplantation of GSDMD pores disseminates pyroptosis, revealing a domino-like effect governing disease-associated bystander cell death. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bystander%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bystander</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caspase-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">caspase-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caspase-11%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">caspase-11</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gasdermin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gasdermin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammasomes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammasomes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sepsis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sepsis</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Vesicles%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Vesicles/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bystander+Effect%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bystander Effect</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Membrane%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Membrane/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alarmins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alarmins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gasdermins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gasdermins</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Chen S</b>, Wu GD, Li T, Jiang J, Zhong Y, Sun D, Qian F, Huang LS. Targeting <span class="highlight-field">GSDMD</span> JX06 inhibits PANoptosis and multiple organ injury. <em class='incite-journal-name' onclick='ShowInCiteJournal(3279);'>Biochem Pharmacol</em> 2025;<b>233</b>:116765. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39848475' target='_blank'>39848475</a> DOI: <a href='https://dx.doi.org/10.1016/j.bcp.2025.116765' target='_blank'>10.1016/j.bcp.2025.116765</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bcp.2025.116765','39848475', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.bcp.2025.116765' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3279);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/20/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/25/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.bcp.2025.116765" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Multiple organ dysfunction syndrome (MODS) is the major cause of mortality of patients in intensive care units. The elusive mechanisms of tissue damage in MODS and limited therapeutic options encourage us to seek effective therapies to MODS. PANoptosis has recently been proven to be the key player in both heat stress and sepsis-mediated MODS. Therefore, we initially investigated the role of gasdermin D (GSDMD) in heat stress and sepsis-induced MODS. We found that GSDMD deficiency attenuates heat stress or sepsis mediated cell death, tissue inflammation and severe multiple organ injury (MOI). Next, we screened out and proved that JX06 effectively inhibited GSDMD-NT mediated cell death, by covalently modifying the Cys39/192 residue in GSDMD, inhibiting the accumulation of GSDMD-NT and pore formation in cell membrane. In vivo, JX06 administration attenuated heat stress and sepsis-mediated cell death, inflammation, MODS and animal mortality via suppressing GSDMD-mediated PANoptosis. Overall, our results indicated that GSDMD is critical for MODS by executing PANoptosis; administrating its inhibitor, JX06, effectively suppresses MODS by inhibiting PANoptosis, and suggesting that JX06 would be an effective drug candidate for MODS and related death. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Heat+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Heat stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MODS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MODS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PANoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PANoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sepsis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sepsis</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Englert H</b>, Rangaswamy C, Kullik GA, Divivier M, Göbel J, Hermans‐Borgmeyer I, Borgmeyer U, Mowen KA, Beerens M, Frye M, Mailer RK, Gelderblom M, Stavrou EX, Preston RJS, Schneider SW, Fuchs TA, Renné T. Sepsis-induced NET formation requires MYD88 but is independent of <span class="highlight-field">GSDMD</span> and PAD4. <em class='incite-journal-name' onclick='ShowInCiteJournal(169488);'>FASEB J</em> 2025;<b>39</b>:e70301. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39777764' target='_blank'>39777764</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707982' target='_blank'>PMC11707982</a> DOI: <a href='https://dx.doi.org/10.1096/fj.202402514r' target='_blank'>10.1096/fj.202402514r</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1096/fj.202402514r','39777764', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(12);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1096/fj.202402514r' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/0f101b0418e5807c6fc2b4f0e3b0a5fd/FSB2-39-e70301.PMC11707982.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1096/fj.202402514r');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169488);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/30/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1096/fj.202402514r" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neutrophils are peripheral blood-circulating leukocytes that play a pivotal role in host defense against bacterial pathogens which upon activation, they release web-like chromatin structures called neutrophil extracellular traps (NETs). Here, we analyzed and compared the importance of myeloid differentiation factor 88 (MYD88), peptidyl arginine deiminase 4 (PAD4), and gasdermin D (GSDMD) for NET formation in vivo following sepsis and neutrophilia challenge. Injection of lipopolysaccharide (LPS)/E. coli or the transgenic expression of granulocyte colony-stimulating factor (G-CSF), each induced NET-mediated lethal vascular occlusions in mice with combined genetic deficiency in Dnase1 and Dnase1l3 (D1/D1l3-/-). In accordance with the signaling of toll-like receptors, Myd88/D1/D1l3-/- animals were protected from the formation of lethal intravascular NETs during septic conditions. However, this protection was not observed during neutrophilia. It was unexpected to find that both Gsdmd/D1/D1l3-/- and Pad4/D1/D1l3-/- mice were fully capable of forming NETs upon LPS/E.coli challenge. Sepsis equally triggered a similar inflammatory response in these mice characterized by formation of DNA-rich thrombi, vessel occlusions, and mortality from pulmonary embolism, compared to D1/D1l3-/- mice. Pharmacologic GSDMD inhibitors did not reduce PMA-stimulated NET formation in ex vivo models either. Similarly, neither Pad4 nor GSDMD deficiency affected intravascular occlusive NET formation upon neutrophilia challenge. The magnitude of NET production, multi-organ damage, and lethality were comparable to those observed in challenged control mice. In conclusion, our data indicate that NET formation during experimental sepsis and neutrophilia is regulated by distinct stimulus-dependent pathways that may be independent of canonical PAD4 and GSDMD. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PAD4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PAD4</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunothrombosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunothrombosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neutrophil+extracellular+traps%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neutrophil extracellular traps</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22vascular+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">vascular biology</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Traps%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Traps/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sepsis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sepsis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein-Arginine+Deiminase+Type+4%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein-Arginine Deiminase Type 4/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myeloid+Differentiation+Factor+88%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myeloid Differentiation Factor 88/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myeloid+Differentiation+Factor+88%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myeloid Differentiation Factor 88/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neutrophils%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neutrophils/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gasdermins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gasdermins</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Deutsche+Forschungsgemeinschaft+(DFG)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P06/KFO306 Deutsche Forschungsgemeinschaft (DFG)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Deutsche+Forschungsgemeinschaft+(DFG)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">INST 152/876-1 FUGG Deutsche Forschungsgemeinschaft (DFG)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Deutsche+Forschungsgemeinschaft+(DFG)%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Deutsche Forschungsgemeinschaft (DFG) </a></li></ul> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Fu X</b>, Xu W, Yang Y, Li D, Shi W, Li X, Chen N, Lv Q, Shi Y, Xu J, Xu J, Yan Y, Shi F, Li X. Diverse strategies utilized by coronaviruses to evade antiviral responses and suppress pyroptosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(11467);'>Int J Biol Macromol</em> 2025;<b>296</b>:139743. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39798756' target='_blank'>39798756</a> DOI: <a href='https://dx.doi.org/10.1016/j.ijbiomac.2025.139743' target='_blank'>10.1016/j.ijbiomac.2025.139743</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ijbiomac.2025.139743','39798756', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.ijbiomac.2025.139743' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11467);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/08/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/15/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.ijbiomac.2025.139743" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Viral infections trigger inflammasome-mediated caspase-1 activation. Nevertheless, limited understanding exists regarding how viruses use the active caspase-1 to evade host immune response. Here, we use porcine epidemic diarrhea virus (PEDV) as a model of coronaviruses (CoVs) to illustrate the intricate regulation of CoVs to combat IFN-I signaling and pyroptosis. Our findings demonstrate that PEDV infection stabilizes caspase-1 expression via papain-like protease PLP2's deubiquitinase activity. This stabilization of caspase-1 disrupts IFN-I signaling by cleaving RIG-I at the D189 residue. Furthermore, we demonstrate that 6-thioguanine (6TG), a PLP2 inhibitor, reverses the inhibitory effect on IFN-I signaling mediated by PLP2 and significantly reduces PEDV replication. Additionally, PLP2 degrades GSDMD-p30 by removing its K27-linked ubiquitin chain at K275 to restrain pyroptosis. Papain-like proteases from other genera of CoVs (PDCoV and SARS-CoV-2) have the similar activity to degrade GSDMD-p30. We further demonstrate that SARS-CoV-2 N protein induced NLRP3 inflammasome activation also uses the active caspase-1 to counter IFN-I signaling by cleaving RIG-I. Therefore, our work unravels a novel antagonistic mechanism employed by CoVs to evade host antiviral response. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antiviral+immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antiviral immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coronavirus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Coronavirus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Papain-like+protease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Papain-like protease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Type+I+interferon+signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Type I interferon signaling</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Jia C</b>, Zhang M, Wu X, Zhang X, Lv Z, Zhao K, Zhang J, Su Y, Zhu F. HERV-W Env Induces Neuron Pyroptosis via the NLRP3-CASP1-<span class="highlight-field">GSDMD</span> Pathway in Recent-Onset Schizophrenia. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2025;<b>26</b>:520. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39859234' target='_blank'>39859234</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11765033' target='_blank'>PMC11765033</a> DOI: <a href='https://dx.doi.org/10.3390/ijms26020520' target='_blank'>10.3390/ijms26020520</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms26020520','39859234', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(14);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.3390/ijms26020520' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/ijms26020520');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/01/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/05/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/30/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.3390/ijms26020520" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">HERVs (Human endogenous retroviruses) are remnants of ancient exogenous retroviruses that have integrated into the human genome, particularly in germ-line cells. Among these, the envelope protein gene HERV-W env (Human endogenous retroviruses W family envelope protein), located on chromosome 7 and primarily expressed in the human placenta, has been closely linked to various neuropsychiatric disorders, including schizophrenia, as well as autoimmune diseases and cancer. Recent studies have highlighted the abnormal expression of cytokines as a key factor in the pathophysiology of schizophrenia. Notably, elevated serum levels of IL-1β (interleukin 1 beta) in schizophrenia, a cytokine associated with inflammation, are a characteristic feature of pyroptosis-a form of pro-inflammatory programmed cell death. Although previous research has observed significant upregulation of pyroptosis-related genes such as CASP1 (Caspase-1), NLRP3 (NLR family pyrin domain containing 3), and IL1B (interleukin 1 beta) in the serum of schizophrenia patients, and extensive neuron pyroptosis has been documented in various neuropsychiatric disorders, including Alzheimer's disease, epilepsy, and multiple sclerosis, the occurrence of neuron pyroptosis in schizophrenia remains uncertain. Furthermore, the mechanisms underlying pyroptosis in schizophrenia and its potential connection with HERV-W env have yet to be fully elucidated. In this study, we found that the expression levels of pyroptosis-related genes, specifically CASP1, GSDMD (Gasdermin D), and IL1B, were significantly elevated in patients with schizophrenia compared to healthy controls. Furthermore, our analysis revealed a strong positive correlation between HERV-W env expression and the levels of CASP1/GSDMD/IL1B in these patients. Experimental evidence further demonstrated that HERV-W env promoted the activation of Caspase-1 and the cleavage of Gasdermin D, leading to increased release of LDH (lactate dehydrogenase) and IL-1β. Importantly, inhibitors targeting NLRP3, CASP1, and GSDMD significantly reduced the releases of LDH and IL-1β induced by HERV-W env, whereas BID (BH3 interacting domain death agonist) inhibitors did not have a notable effect. This suggests that HERV-W env induces CASP1-GSDMD-dependent pyroptosis through the NLRP3-CASP1-GSDMD signaling pathway. As pyroptosis is increasingly recognized for its connection to neurodegenerative diseases, this study provides insights into the molecular mechanisms of neuronal pyroptosis mediated by the NLRP3 inflammasome in the context of HERV-W env. Additionally, it explores the potential facilitation of HERV-W env in the development of schizophrenia via pyroptosis, proposing that certain pyroptosis indicators could serve as potential biomarkers for schizophrenia. Based on our existing research results and the findings of previous researchers, we infer that HERV-W env acts as a bridge in the onset and progression of schizophrenia. Furthermore, HERV-W env may serve as a potential target for the clinical treatment of schizophrenia, suggesting that monoclonal antibody therapy targeting HERV-W env could represent a novel approach to managing this disease. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CASP1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CASP1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HERV-W+env%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HERV-W env</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IL1B%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IL1B</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22schizophrenia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">schizophrenia</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schizophrenia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schizophrenia/metabolism</a></li><li><a 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style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nos. 82272321 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fundamental+Research+Funds+for+the+Central+Universities%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2042023kf0230 Fundamental Research Funds for the Central Universities</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stanley+Foundation+from+the+Stanley+Medical+Research+Institute+(SMRI)%2c+United+States%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">No.06R- 1366 Stanley Foundation from the Stanley Medical Research Institute (SMRI), United States</a></li></ul> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Liu J</b>, Han C, Shen J, Lin Y, Shen H, Wang G. Acrylamide exposure promotes the progression of depression-like behavior in mice with CUMS via <span class="highlight-field">GSDMD</span>-mediated pyroptosis. <em>ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY</em> 2025;<b>289</b>:117443. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39622127' target='_blank'>39622127</a> DOI: <a href='https://dx.doi.org/10.1016/j.ecoenv.2024.117443' target='_blank'>10.1016/j.ecoenv.2024.117443</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ecoenv.2024.117443','39622127', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.ecoenv.2024.117443' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/30/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1016/j.ecoenv.2024.117443" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">AIM</div><div class="abstract-content">We investigated the mechanism by which the environmental toxin acrylamide (AM) promotes depression. </div><div class="abstract-label">METHODS</div><div class="abstract-content">A depression mouse model was constructed using the chronic unpredictable mild stress method, AM was administered orally to simulate the exposure state. Depressive-like behavioral changes were assessed by open field test, elevated plus maze test, swimming test, and sucrose preference test. Enzyme-linked immunosorbent assay (ELISA) was used to detect tissue inflammatory factor levels, hematoxylin and eosin (H&E) and Nissl staining to detect neuronal damage, immunohistochemical staining to detect IBA-1 expression, and Western-blotting to detect protein levels. GSDMD knockout (KO) mice and the GSDMD inhibitor LDC7559 were used to inhibit GSDMD. In vitro, primary microglia were used, and AM intervention was applied to detect the levels of cellular inflammatory factors, and fluorescence staining was used to detect GSDMD-NT, and propidium iodide (PI) was used to detect the level of pyroptosis. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">AM can exacerbate CUMS-like depression in mice, increase the levels of inflammatory factors in brain tissue, and worsen neuronal damage, with upregulation of IBA-1 expression, and can increase the expression of NLRP3, GSDMD, and GSDMD-NT. When GSDMD-KO or LDC7559 intervention was applied, it could antagonize the effects of AM and improve CUMS-like depression. In microglial cell experiments, AM could promote pyroptosis in microglial cells, increase the expression of inflammatory factors, and when GSDMD-KO was applied, it could inhibit the effects of AM. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">AM can promote the progression of depression in CUMS-like mice via GSDMD-mediated pyroptosis, while also increasing tissue inflammatory levels. GSDMD is an important target for the neurotoxicity of AM. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acrylamide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acrylamide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CUMS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CUMS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acrylamide%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acrylamide/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Behavior%2c+Animal%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Behavior, Animal/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Psychological%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Psychological/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gasdermins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gasdermins</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Sun JQ</b>, Sheng B, Gao S, Liu XZ, Cui Y, Peng Z, Chen XX, Ding PF, Zhuang Z, Wu LY, Hang CH, Li W. SIRT2 Promotes NLRP3-Mediated Microglia Pyroptosis and Neuroinflammation via FOXO3a Pathway After Subarachnoid Hemorrhage. <em class='incite-journal-name' onclick='ShowInCiteJournal(14247);'>J Inflamm Res</em> 2024;<b>17</b>:11679-11698. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39741753' target='_blank'>39741753</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11687285' target='_blank'>PMC11687285</a> DOI: <a href='https://dx.doi.org/10.2147/jir.s487716' target='_blank'>10.2147/jir.s487716</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.2147/jir.s487716','39741753', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.2147/jir.s487716' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/e805766f4b761950b7d8368abfc74950/jir-17-11679.PMC11687285.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.2147/jir.s487716');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14247);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/03/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.2147/jir.s487716" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Purpose</div><div class="abstract-content">This study primarily elucidating the specific mechanism of SIRT2 on neuroinflammation and microglial pyroptosis in a mouse model of SAH. </div><div class="abstract-label">Patients and Methods</div><div class="abstract-content">CSF were collected from 57 SAH patients and 11 healthy individuals. C57BL/6 mouse SAH model was established using prechiasmatic cistern blood injection and the in vitro hemoglobin (Hb) stimulation microglia model. Lentivirus was used as a vector for RNA interference technology to knock down the SIRT2 gene expression. Small interfering RNA was used to knockdown the expression of FOXO3a. The tools included measurements of brain water content, neurological scores, Western blot, PCR, ELISA, TEM, immunofluorescence, LDH assay, modified Garcia score, and balance beam tests to evaluate changes in pyroptosis and neuroinflammatory responses. </div><div class="abstract-label">Results</div><div class="abstract-content">In CSF samples from SAH patients, elevated levels of SIRT2 and GSDMD were observed, with SIRT2 demonstrating particular diagnostic value for predicting prognosis at the 3-month follow-up. SIRT2 upregulation exacerbated neurological deficits, brain edema, and blood-brain barrier disruption in mice following SAH. SIRT2 increased GSDMD, caspase-1, and IL-1β/IL-18 expression, and amplified GSDMD-positive microglia. FOXO3a was also upregulated post-SAH. siRNA-mediated SIRT2 knockdown ameliorated microglial pyroptosis after SAH. FOXO3a siRNA reduced NLRP3 inflammasome activation and microglial pyroptosis severity, along with neuroinflammation post-SAH. </div><div class="abstract-label">Conclusion</div><div class="abstract-content">In summary, SIRT2 promoted microglial pyroptosis, primarily by increasing the expression and activity of Foxo3a, thereby exacerbating neuroinflammatory damage following subarachnoid hemorrhage. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FOXO3a%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FOXO3a</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SIRT2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SIRT2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microglial+pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microglial pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22subarachnoid+hemorrhage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">subarachnoid hemorrhage</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Ye B</b>, Cai X, Liang X, Chen Y, Dai S, Huang Z, Huang W, Zhang L, Wang Z, Xing J, Lai X, Huang Z, Jia Z. Emodin Suppresses NLRP3/<span class="highlight-field">GSDMD</span>-induced Inflammation via the TLR4/MyD88/NF-κB Signaling Pathway in Atherosclerosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(4642);'>Cardiovasc Drugs Ther</em> 2024:10.1007/s10557-024-07659-w. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39715879' target='_blank'>39715879</a> DOI: <a href='https://dx.doi.org/10.1007/s10557-024-07659-w' target='_blank'>10.1007/s10557-024-07659-w</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s10557-024-07659-w','39715879', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(17);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1007/s10557-024-07659-w' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4642);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/cdty/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/25/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1007/s10557-024-07659-w" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">PURPOSE</div><div class="abstract-content">Inflammatory responses induced by NLRP3 inflammasome contribute to the progression of atherosclerosis. This study seeks to investigate the effect of emodin on the NLRP3 inflammasome in atherogenesis and to probe the underlying mechanism. </div><div class="abstract-label">METHODS</div><div class="abstract-content">ApoE-knockout (ApoE-/-) mice were treated with a high-fat diet (HFD) for 12 weeks and intragastrically with emodin for 6 weeks. Human mononuclear cell line THP-1 was pretreated with emodin or signaling pathway inhibitors and induced into macrophages using phorbol 12-myristate 13-acetate (PMA) for 48 h. The NLRP3-mediated inflammatory response was studied both in vivo and in vitro. The level of the inflammation was detected by western blot, real-time PCR analysis, and ELISA. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Emodin attenuated atherosclerotic lesions in HFD-treated ApoE-/- mice. Emodin dramatically decreased the expression of NLRP3, GSDMD, IL-1β, and IL-18 in HFD-treated ApoE-/- mice and PMA-induced macrophages. Moreover, emodin significantly hindered the activation of nuclear factor kappa-B (NF-κB) by inhibiting the formation of the TLR4/MyD88 complex in PMA-induced macrophages. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Our data demonstrate that emodin can inhibit the development of atherosclerotic plaques by alleviating NLRP3/GSDMD-induced inflammation through repressing the TLR4/MyD88/NF-κB signaling pathway in macrophages. This finding suggests that emodin can be a potential candidate for the treatment of atherosclerosis. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Emodin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Emodin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-%ce%baB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-κB</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3+inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3 inflammasome</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Taizhou+Municipal+Science+and+Technology+Bureau%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">23ywb144 Taizhou Municipal Science and Technology Bureau</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Zhejiang+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LY22H020004 Natural Science Foundation of Zhejiang Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Zhejiang+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LQ23H310005 Natural Science Foundation of Zhejiang Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Zhejiang+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LGF22H020016 Natural Science Foundation of Zhejiang Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82070446 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82202380 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zhejiang+Traditional+Chinese+Medicine+Administration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2022ZA096 Zhejiang Traditional Chinese Medicine Administration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+and+Technology+Plan+Project+of+Wenzhou+Municipality%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Y2023101 Science and Technology Plan Project of Wenzhou Municipality</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Major+Scientific+and+Technological+Innovation+Project+of+Wenzhou%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2024ZY0050 Major Scientific and Technological Innovation Project of Wenzhou</a></li></ul> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Hu Y</b>, Li H, Zhang X, Song Y, Liu J, Pu J, Wen S, Xu H, Xin H, Wang B, Yang S. Identification of two repurposed drugs targeting <span class="highlight-field">GSDMD</span> oligomerization interface I to block pyroptosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(4699);'>Cell Chem Biol</em> 2024;<b>31</b>:2024-2038.e7. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39486414' target='_blank'>39486414</a> DOI: <a href='https://dx.doi.org/10.1016/j.chembiol.2024.10.002' target='_blank'>10.1016/j.chembiol.2024.10.002</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.chembiol.2024.10.002','39486414', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.chembiol.2024.10.002' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4699);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.chembiol.2024.10.002" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">As an executor of pyroptosis, gasdermin D (GSDMD) plays a critical role in inflammatory diseases and cancer. Thus, GSDMD is currently being widely explored as a drug target. Existing inhibitors targeting GSDMD, such as necrosulfonamide, disulfiram, and fumarate, primarily prevent pyroptosis by modifying human/mouse C191/C192 in the N-terminal fragment of GSDMD. However, cysteine modification can prevent the function of important proteins or enzymes, thereby leading to adverse reactions. Here, we chose an alternative key intervention site for GSDMD activation, which is located at the oligomerization interface I of its pore-forming structure. Through high-throughput virtual and experimental screening and in combination with efficacy and pharmacological validation, we have identified two safe, specific "repurposed drugs" that potently suppress GSDMD-mediated pyroptosis. Moreover, the candidates exhibited synergistic therapeutic effects of "1 + 1>2" in murine sepsis and tumorigenesis models. These recently identified GSDMD inhibitors hold great promise for clinical translation in the development of anti-inflammatory and anti-cancer immunotherapies. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anti-cancer+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anti-cancer inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anti-inflammatory%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anti-inflammatory</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22oligomerization+interface+I%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">oligomerization interface I</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Repositioning%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Repositioning</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gasdermins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gasdermins</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Chen Z</b>, Shang Y, Ou Y, Zhou L, Liu T, Gong S, Xiang X, Peng Y, Ouyang R. Exosomes from IH- Induced bEnd3 Cells Promote OSA Cognitive Impairment via miR-20a-5p/MFN2 Mediated Pyroptosis of HT22 Cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(17555);'>Nat Sci Sleep</em> 2024;<b>16</b>:2063-2082. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39717669' target='_blank'>39717669</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663995' target='_blank'>PMC11663995</a> DOI: <a href='https://dx.doi.org/10.2147/nss.s485952' target='_blank'>10.2147/nss.s485952</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.2147/nss.s485952','39717669', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.2147/nss.s485952' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/9f4d2def7976f6fe027e1884fb2ef681/nss-16-2063.PMC11663995.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.2147/nss.s485952');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17555);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.dovepress.com/submit_step_1.php' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/25/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.2147/nss.s485952" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">OSA can cause cognitive impairment (CI). The aim of this study was to investigate whether miR-20a-5p in exosomes derived from bEnd3 cells with IH mediates intercellular crosstalk and induces CI through hippocampal neuronal cell pyroptosis. </div><div class="abstract-label">Materials and Methods</div><div class="abstract-content">BEnd3-derived exosomes were isolated from the normal oxygen control group (NC-EXOS) and IH group (IH-EXOS). In vitro, exosomes were cocultured with HT22 cells. Meanwhile, in vivo, exosomes were injected into mice via the caudal vein. The spatial memory ability of mice was tested by MWM method to evaluate the effect of exosomes on the cognitive function of mice. Adults diagnosed with OSA underwent the MoCA and ESS tests to assess cognitive function and daytime sleepiness. Spearman's rank correlation analysis was used to evaluate the correlation between miR-20a-5p and candidate proteins and clinical parameters. Transfection using small interfering RNAs, miRNA mimics, and plasmids to evaluate the role of miR-20a-5p and its target genes. Dual luciferase reporter gene assay was used to confirm the binding of miR-20a-5p to its target gene. </div><div class="abstract-label">Results</div><div class="abstract-content">IH could cause pyroptosis and inflammation in bEnd3 cells, and promote the expression of miR-20a-5p. Isolated IH-EXOS induced increased pyroptosis and activation of inflammatory response in vitro and in vivo, accompanied by increased expression of miR-20a-5p. In addition, IH-EXOS led to decreased learning and memory ability in mice. Interestingly, AHI was higher and MoCA scores were lower in severe OSA compared to healthy comparisons. In addition, miR-20a-5p and GSDMD were positively correlated with AHI but negatively correlated with MoCA in severe OSA. IH-induced exosomes were rich in miR-20a-5p, and these exosomes were found to deliver miR-20a-5p to HT22 cells, playing a key role in the induction of OSA-CI by directly targeting MFN2. </div><div class="abstract-label">Conclusion</div><div class="abstract-content">Exosome miR-20a-5p from IH-stimulated bEnd3 cells can promote OSA-CI by increasing HT22 cells pyroptosis through its target MFN2. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MFN2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MFN2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22OSA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">OSA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cognitive+impairment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cognitive impairment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22exosome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">exosome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miR-20a-5p%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miR-20a-5p</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Lang Y</b>, Li J, Zhang L. O-GlcNAcylation dictates pyroptosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(9345);'>Front Immunol</em> 2024;<b>15</b>:1513542. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39742284' target='_blank'>39742284</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685218' target='_blank'>PMC11685218</a> DOI: <a href='https://dx.doi.org/10.3389/fimmu.2024.1513542' target='_blank'>10.3389/fimmu.2024.1513542</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fimmu.2024.1513542','39742284', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.3389/fimmu.2024.1513542' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fimmu.2024.1513542');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9345);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/03/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.3389/fimmu.2024.1513542" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">O-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine to serine and threonine residues. This review emphasizes its role in regulating the signaling pathways of pyroptosis. Specifically, the O-GlcNAcylation of GSDMD is linked to the modulation of pyroptosis, suggesting that enhancing O-GlcNAcylation of GSDMD could be crucial for improving hypoperfusion in sepsis. Additionally, GSDME, another member of the gasdermin family, facilitates macrophage pyroptosis through O-GlcNAcylation induced by high glucose levels in the context of periodontitis. The review also examines the effects of O-GlcNAcylation on the NLRP3 inflammasome and its regulators, including NEK7 and NF-κB. Overall, this review emphasizes the role of O-GlcNAcylation in the pathogenesis of conditions such as sepsis, periodontitis, and osteoarthritis, identifying potential therapeutic targets for managing inflammatory responses through its targeted modulation. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDME%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDME</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22O-GlcNAcylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">O-GlcNAcylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pyroptosis</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Processing%2c+Post-Translational%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Processing, Post-Translational</a></li><li><a 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target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gasdermins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gasdermins</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Zhu L</b>, Tong H, Ren C, Chen K, Luo S, Wang Q, Guo M, Xu Y, Hu M, Fang J, Xu J, Shi P. Inflammation unleashed: The role of pyroptosis in chronic liver diseases. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>141</b>:113006. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39213865' target='_blank'>39213865</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113006' target='_blank'>10.1016/j.intimp.2024.113006</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113006','39213865', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.113006' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1016/j.intimp.2024.113006" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pyroptosis, a newly identified form of programmed cell death intertwined with inflammatory responses, is facilitated by the Gasdermin family's pore-forming activity, leading to cell lysis and the release of pro-inflammatory cytokines. This process is a double-edged sword in innate immunity, offering protection against pathogens while risking excessive inflammation and tissue damage when dysregulated. Specifically, pyroptosis operates through two distinct signaling pathways, namely the Caspase-1 pathway and the Caspase-4/5/11 pathway. In the context of chronic liver diseases like fibrosis and cirrhosis, inflammation emerges as a central contributing factor to their pathogenesis. The identification of inflammation is characterized by the activation of innate immune cells and the secretion of pro-inflammatory cytokines such as IL-1α, IL-1β, and TNF-α. This review explores the interrelationship between pyroptosis and the inflammasome, a protein complex located in liver cells that recognizes danger signals and initiates Caspase-1 activation, resulting in the secretion of IL-1β and IL-18. The article delves into the influence of the inflammasome and pyroptosis on various liver disorders, with a specific focus on their molecular and pathophysiological mechanisms. Additionally, the potential therapeutic implications of targeting pyroptosis for liver diseases are highlighted for future consideration. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caspase-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Caspase-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3+Inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3 Inflammasome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Diseases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Diseases/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammasomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammasomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammasomes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammasomes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chronic+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chronic Disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Huang J</b>, Shi J, Zhang X, Tian F, Huang J, Zhao Q, Wan N, Zhang L, Hu Y, Li P. Serum Gasdermin D for Early Diagnosis of Bloodstream Infection and Differentiating Bacterial From Fungal Infections. <em class='incite-journal-name' onclick='ShowInCiteJournal(14244);'>J Infect Dis</em> 2024;<b>230</b>:1235-1242. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38669226' target='_blank'>38669226</a> DOI: <a href='https://dx.doi.org/10.1093/infdis/jiae217' target='_blank'>10.1093/infdis/jiae217</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/infdis/jiae217','38669226', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(22);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1093/infdis/jiae217' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14244);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/30/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/28/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1093/infdis/jiae217" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">The role of gasdermin D (GSDMD) in bloodstream infection (BSI) diagnosis is unknown. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Serum GSDMD levels were measured in patients with BSI. Endothelial cells and peripheral blood mononuclear cells were isolated and infected with bacteria/fungi, and intracellular/extracellular GSDMD concentrations were measured. An animal model was established to investigate the association between serum GSDMD levels and BSI incidence or progression. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Receiver operating characteristic curve analysis indicated that GSDMD could be a potential early diagnostic biomarker for BSI (area under the curve [AUC], .9885). Combining GSDMD with procalcitonin improved the differential diagnosis of gram-positive and gram-negative bacteria (AUC, 0.6699; 66.15% specificity) and early diagnosis of gram-positive bacteria (98.46% sensitivity), while procalcitonin was not significantly elevated. The combined GSDMD and (1-3)-β-D glucan test (G test) had higher sensitivity (AUC, 0.7174) for differential diagnosis of bacterial and fungal infections and early detection of fungal infections (98.44% sensitivity). In vitro and in vivo experiments confirmed that GSDMD levels increased significantly within 2 hours, peaked at 16 hours, and exhibited a time-dependent upward trend. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Serum GSDMD, alone or combined with other biomarkers, has potential for early diagnosis and differential diagnosis of BSI caused by various pathogens. This finding offers a new strategy for early detection and treatment of BSI. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biomarker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bloodstream+infection%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bloodstream infection</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22diagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pyroptosis</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Early+Diagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Early Diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a 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</div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chongqing+Science+and+Technology+Bureau%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chongqing Science and Technology Bureau</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chongqing+Municipal+Health+Commission%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2023MSXM117 Chongqing Municipal Health Commission</a></li></ul> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Zhang N</b>, Yang Y, Xu D. Emerging roles of palmitoylation in pyroptosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(22955);'>Trends Cell Biol</em> 2024:S0962-8924(24)00211-3. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39521664' target='_blank'>39521664</a> DOI: <a href='https://dx.doi.org/10.1016/j.tcb.2024.10.005' target='_blank'>10.1016/j.tcb.2024.10.005</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.tcb.2024.10.005','39521664', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.tcb.2024.10.005' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(22955);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.tcb.2024.10.005" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pyroptosis is a lytic, proinflammatory type of programmed cell death crucial for the immune response to pathogen infections and internal danger signals. Gasdermin D (GSDMD) acts as the pore-forming protein in pyroptosis following inflammasome activation. While recent research has improved our understanding of pyroptosis activation and execution, many aspects regarding the molecular mechanisms controlling inflammasome and GSDMD activation remain to be elucidated. A growing body of literature has shown that S-palmitoylation, a reversible post-translational modification (PTM) that attaches palmitate to cysteine residues, contributes to multi-layered regulation of pyroptosis. This review summarizes the emerging roles of S-palmitoylation in pyroptosis research with a focus on mechanisms that regulate NLRP3 inflammasome and GSDMD activation. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gasdermin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gasdermin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammasome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pyroptosis</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Wen Z</b>, Yuan T, Liu J, Wang D, Ni J, Yan X, Tang J, Tang J, Wu X, Wang Z. Atg16l2 augments Nlrc4 inflammasome activation by facilitating NAIPs-NLRC4 association. <em class='incite-journal-name' onclick='ShowInCiteJournal(8853);'>Eur J Immunol</em> 2024;<b>54</b>:e2451078. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39175123' target='_blank'>39175123</a> DOI: <a href='https://dx.doi.org/10.1002/eji.202451078' target='_blank'>10.1002/eji.202451078</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/eji.202451078','39175123', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/eji.202451078' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8853);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/24/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1002/eji.202451078" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">As cytoplasmic protein complexes that are pivotal for innate immunity, inflammasomes act primarily through the detection of pathogen- or danger-associated molecular patterns. Nucleotide oligomerisation domain-like receptor family and caspase activation recruitment domain-containing protein 4 (NLRC4) inflammasomes identify and eliminate intracellular pathogens, a process contingent on the ligand-recognition capabilities of neuronal apoptosis inhibitory proteins (NAIPs). Upon detection of specific molecules indicative of intracellular infection, NAIPs discern distinct pathogenic components and subsequently transmit signals to NLRC4, thus initiating their activation and triggering an inflammatory response. However, the mechanisms underlying NLRC4 inflammasome remain unclear. In this study, we elucidated the critical role of ATG16L2 in activating the NLRC4 inflammasome. ATG16L2-deficient macrophages exhibited reduced NLRC4 inflammasome activation, characterised by decreased oligomerisation of apoptosis-associated speck-like protein containing a CARD and attenuated cleavage of Pro-caspase-1, Pro-IL-1β and gasdermin D. Co-immunoprecipitation assays revealed an interaction between ATG16L2 and NAIPs. Furthermore, ATG16L2 enhanced the association between NAIPs and NLRC4 by binding to NAIPs. For ATG16L2-knockout mice infected with Salmonella typhimurium, pathogen clearance and survival rates markedly decreased. Collectively, our findings suggest that ATG16L2 is a significant modulator of the innate immune system, influencing the activity of the NLRC4 inflammasome and the host's defensive response to intracellular pathogens. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATG16L2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATG16L2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammasome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammasome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NAIPs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NAIPs</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a 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China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+and+Technology+Commission+of+Shanghai+Municipality%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">21ZR1456200 Science and Technology Commission of Shanghai Municipality</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+and+Technology+Commission+of+Shanghai+Municipality%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">19140903002 Science and Technology Commission of Shanghai Municipality</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Innovative+Research+Team+of+High-Level+Local+Universities+in+Shanghai%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SHSMUZDCX20212000 Innovative Research Team of High-Level Local Universities in Shanghai</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shanghai+Frontiers+Science+Center+of+Cellular+Homeostasis+Regulation+and+Human+Diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shanghai Frontiers Science Center of Cellular Homeostasis Regulation and Human Diseases</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Yan Y</b>, Li J, He Y, Ji P, Xu J, Li Y. Potential pro-tumour cytokine in oral squamous cellular carcinoma: IL37. <em class='incite-journal-name' onclick='ShowInCiteJournal(12461);'>J Cell Mol Med</em> 2024;<b>28</b>:e70167. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39500733' target='_blank'>39500733</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537803' target='_blank'>PMC11537803</a> DOI: <a href='https://dx.doi.org/10.1111/jcmm.70167' target='_blank'>10.1111/jcmm.70167</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/jcmm.70167','39500733', 'GSDMD')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(25);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/jcmm.70167' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1111/jcmm.70167');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12461);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/06/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/09/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1111/jcmm.70167" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Inflammation and immunosuppression are important features of tumours, including oral squamous cellular carcinoma (OSCC). Interleukin 37 (IL37), a cytokine known for the ability to suppress inflammation and immunity, shows two seemingly contradictory functions in tumours. This study aims to investigate the mechanism that regulates IL37 and its role in OSCC progression. Herein, IL37, CD86 and CD206 in OSCC specimens were determined. Hypoxia, MCC950 and siRNA-Gasdermin D (GSDMD) were utilised to investigate the mechanism of IL37 production and release. Animal experiments were established to examine the role of IL37 in OSCC growth in vivo. We found the levels of IL37 are elevated in OSCC tissues compared with normal oral mucosa. In cell experiments, hypoxia was proved to be a vital facilitator in IL37 expression and release. Mechanically, hypoxia promoted IL37 expression through the activation of NACHT-LRR-PYD-containing protein 3 (NLRP3) inflammasome, and promoted IL37 release via GSDMD. Furthermore, IL37 levels in OSCC specimens are positively correlated with the number of M2 macrophages, but negatively with M1. Further studies revealed IL37 facilitated OSCC progression via promoting macrophage polarization from M1 to M2 and enhancing tumour cell proliferation. Thus, IL37 could be a promising target for OSCC treatment in the future. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IL37%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IL37</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a 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class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">GSDMD (280 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="280" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">GSDMD (280 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="280" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>