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more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Xiang RR</b>, Lee SA, Tyndall CF, Bhatia AR, Yin J, Singler C, Hauk BJ, Kipp MP, Takeda DY. CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115312. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39954255' target='_blank'>39954255</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2025.115312' target='_blank'>10.1016/j.celrep.2025.115312</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2025.115312','39954255', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2025.115312' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/23/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/17/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.celrep.2025.115312" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Amplification of the androgen receptor (AR) locus is the most frequent alteration in metastatic castration-resistant prostate cancer (CRPC). Recently, it was discovered that an enhancer of the AR is co-amplified with the AR gene body and contributes to increased AR transcription and resistance to androgen deprivation therapy. However, the mechanism of enhancer activation in advanced disease is unknown. Here, we used CRISPR-Cas9 screening to identify transcription factors that bind to the AR enhancer and modulate enhancer-mediated AR transcription. We demonstrate that HOXB13, GATA2, and TFAP2C bind the AR enhancer in patient-derived xenografts and directly impact features associated with an active chromatin state. Interestingly, the AR enhancer belongs to a set of regulatory elements that require HOXB13 to maintain FOXA1 binding, further delineating the role of HOXB13 in CRPC. This work provides a framework to functionally identify trans-acting factors required for the activation of disease-related noncoding regulatory elements. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Molecular+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Molecular biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CRISPR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CRISPR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CRPC%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CRPC</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22androgen+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">androgen receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22enhancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">enhancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epigenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epigenetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22functional+genomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">functional genomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prostate+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prostate cancer</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Tang WW</b>, Battistone B, Bauer KM, Weis AM, Barba C, Fadlullah MZH, Ghazaryan A, Tran VB, Lee SH, Agir ZB, Nelson MC, Victor ES, Thibeaux A, Hernandez C, Tantalla J, Tan AC, Rao D, Williams M, Drummond MJ, Beswick EJ, Round JL, Ekiz HA, Voth WP, O'Connell RM. A microRNA-regulated transcriptional state defines intratumoral CD8<sup>+</sup> T cells that respond to immunotherapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115301. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39951377' target='_blank'>39951377</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2025.115301' target='_blank'>10.1016/j.celrep.2025.115301</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2025.115301','39951377', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2025.115301' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/22/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/16/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.celrep.2025.115301" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The rising incidence of advanced-stage colorectal cancer (CRC) and poor survival outcomes necessitate new and effective therapies. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 therapy, show promise, yet clinical determinants of a positive response are suboptimal. Here, we identify microRNA-155 (miR-155) as necessary for CD8+ T cell-infiltrated tumors through an unbiased in vivo CRISPR-Cas9 screen identifying functional tumor antigen-specific CD8+ T cell-expressed microRNAs. T cell miR-155 is required for anti-PD-1 responses and for a vital intratumor CD8+ T cell differentiation cascade by repressing Ship-1, inhibiting Tcf-1 and stemness, and subsequently enhancing Cxcr6 expression, anti-tumor immunity, and effector functions. Based on an underlying miR-155-dependent CD8+ T cell transcriptional profile, we identify a gene signature that predicts ICI responses across 12 diverse cancers. Together, our findings support a model whereby miR-155 serves as a central regulator of CD8+ T cell-dependent cancer immunity and ICI responses that may be leveraged for future therapeutics. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD8(%2b)+T%c2%a0cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD8(+) T cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Immunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cxcr6%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cxcr6</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ship-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ship-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tcf-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tcf-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anti-PD-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anti-PD-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biomarker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22colorectal+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">colorectal cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+checkpoint+inhibition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune checkpoint inhibition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microRNA-155%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microRNA-155</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Shen C</b>, Lu W, Merugu SB, Bharti A, Afify SM, Schnitkey L, Wynn DT, Yang F, Rohwetter TM, Nayak A, Bunnag N, Cywiak C, Tang HY, Harris BT, Albanese C, Ihemelandu C, Cobb MH, Kettenbach A, Lee E, Ahmed Y, Robbins DJ. Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115274. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39908140' target='_blank'>39908140</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2025.115274' target='_blank'>10.1016/j.celrep.2025.115274</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2025.115274','39908140', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2025.115274' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/16/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/07/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.celrep.2025.115274" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The mechanism by which Wnt signaling, an essential pathway controlling development and disease, stabilizes β-catenin has been a subject of debate over the last four decades. Casein kinase 1α (CK1α) functions as a pivotal negative regulator of this signaling pathway, initiating the events that destabilize β-catenin. However, whether and how CK1α activity is regulated in Wnt-off and Wnt-on states remains poorly understood. We now show that CK1α activity requires its association with the α catalytic subunit of protein phosphatase 2A (PPP2CA) on AXIN, the scaffold protein of the β-catenin destruction complex. Wnt stimulation induces the dissociation of PPP2CA from CK1α, resulting in CK1α autophosphorylation and its consequent inactivation. Moreover, autophosphorylated CK1α is enriched in a subset of colorectal cancers (CRCs) harboring constitutive Wnt activation. Our findings identify a mechanism by which Wnt stimulation inactivates CK1α, filling a critical gap in our understanding of Wnt signaling, with relevance for CRC. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CK1%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CK1α</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Molecular+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Molecular biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wnt+signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wnt signaling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22colorectal+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">colorectal cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22protein+phosphatase+2A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">protein phosphatase 2A</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Sun L</b>, Fan G, Zhang Z, Chang D, Zhang X, Zhang T, Geng J, Zhang X, Lin M, Hu C, Zhou J, Wang M, Cao L, Zhang M, He B, Zhang S, Wang C. Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115269. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39908142' target='_blank'>39908142</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2025.115269' target='_blank'>10.1016/j.celrep.2025.115269</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2025.115269','39908142', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2025.115269' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/15/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/07/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.celrep.2025.115269" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Drug resistance significantly limits the efficacy of chemotherapy. The DNA mismatch repair (MMR) system maintains genomic stability by correcting DNA errors. During DNA-damaging treatments, cancer cells transiently increase their adaptive mutability, also known as microsatellite instability (MSI), to evade therapeutic pressure through MMR downregulation, conferring drug resistance. However, an understanding of the underlying mechanisms of MMR protein downregulation under DNA-damaging drugs remains limited. Our study reveals a negative correlation between SIRT7 protein levels and MMR core protein MSH2 levels in cervical and lung cancer tissues. SIRT7 destabilizes MSH2, promoting MSI and mutagenesis. Molecularly, DNA damage triggers ATM kinase-dependent phosphorylation and subcellular redistribution of SIRT7. Phosphorylated SIRT7 interacts with and deacetylates MSH2, impairing MMR, and inducing MSI and drug resistance. Our findings suggest that SIRT7 drives MMR downregulation under therapeutic stress and that ATM-dependent phosphorylation of SIRT7 may serve as a predictive biomarker for chemotherapeutic efficacy and a target for cancer treatment. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATM%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATM</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Molecular+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Molecular biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SIRT7%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SIRT7</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22adaptive+mutability%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">adaptive mutability</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microsatellite+instability%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microsatellite instability</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mismatch+repair%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mismatch repair</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Ye L</b>, Shen S, Mao Q, Lu H, Liu H, Zhang P, Jiang Z, Ma W, Sun Y, Chu Y, Zhou Z, Liu R, Li J, Li ST, Gao P, Zhang H. Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115250. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39891906' target='_blank'>39891906</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2025.115250' target='_blank'>10.1016/j.celrep.2025.115250</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2025.115250','39891906', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2025.115250' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/10/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/03/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.celrep.2025.115250" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Metabolic enzymes play significant roles in the pathogenesis of various cancers through both canonical and noncanonical functions. Hexokinase domain-containing protein 1 (HKDC1) functions beyond glucose metabolism, but its underlying mechanisms in tumorigenesis are not fully understood. Here, we demonstrate that nuclear-localized HKDC1 acts as a protein kinase to promote hepatocellular carcinoma (HCC) cell proliferation. Mechanistically, HKDC1 phosphorylates RB binding protein 5 (RBBP5) at Ser497, which is crucial for MLL1 complex assembly and subsequent histone H3 lysine 4 trimethylation (H3K4me3) modification. This leads to the transcriptional activation of mitosis-related genes, thereby driving cell cycle progression and proliferation. Notably, targeting HKDC1's protein kinase activity, but not its HK activity, blocks RBBP5 phosphorylation and suppresses tumor growth. Clinical analysis further reveals that RBBP5 phosphorylation positively correlates with HKDC1 levels and poor HCC prognosis. These findings highlight the protein kinase function of HKDC1 in the activation of H3K4me3, gene expression, and HCC progression. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hepatocellular+carcinoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hepatocellular carcinoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22histone+methylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">histone methylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22post-translational+modification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">post-translational modification</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Tietz KT</b>, McCluskey BM, Miller CR, Li Y, Munro SA, Dehm SM. CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115211. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39847481' target='_blank'>39847481</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115211' target='_blank'>10.1016/j.celrep.2024.115211</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115211','39847481', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115211' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/25/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.celrep.2024.115211" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Localized prostate cancer can be cured by radiation or surgery, but advanced prostate cancer continues to be a clinical challenge. Altered alternative polyadenylation occurs in numerous cancers and can downregulate tumor-suppressor genes and upregulate oncogenes. We found that the cleavage and polyadenylation specificity factor (CPSF) complex factor CPSF1 is upregulated in patients with advanced prostate cancer, with high CPSF1 expression correlating with worse progression-free survival. Knockdown of CPSF1 selectively inhibited the growth of prostate cancer cells and reduced glycolytic output. Evaluating the changes in global poly(A) site usage in prostate cancer cells following CPSF1 knockdown revealed widespread usage of intergenic poly(A) sites distal to annotated 3' UTRs, which lengthened 3' UTRs and decreased levels of thousands of mRNAs, including key glycolysis genes. These findings uncover a role for CPSF1 in the suppression of intergenic poly(A) sites in prostate cancer and nominate CPSF1 as a therapeutic target in advanced prostate cancer. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Molecular+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Molecular biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CPSF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CPSF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glycolysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glycolysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22intergenic+polyadenylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">intergenic polyadenylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prostate+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prostate cancer</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cleavage+And+Polyadenylation+Specificity+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cleavage And Polyadenylation Specificity Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cleavage+And+Polyadenylation+Specificity+Factor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cleavage And Polyadenylation Specificity Factor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polyadenylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polyadenylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycolysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycolysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%223%27+Untranslated+Regions%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">3' Untranslated Regions/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Melo Garcia L</b>, Gangadharan A, Banerjee P, Li Y, Zeng AGX, Rafei H, Lin P, Kumar B, Acharya S, Daher M, Muniz-Feliciano L, Deyter GM, Dominguez G, Park JM, Reyes Silva F, Nunez Cortes AK, Basar R, Uprety N, Shanley M, Kaplan M, Liu E, Shpall EJ, Rezvani K. Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115122. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39754720' target='_blank'>39754720</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115122' target='_blank'>10.1016/j.celrep.2024.115122</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115122','39754720', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(7);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115122' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/06/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.celrep.2024.115122" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">CD226 plays a vital role in natural killer (NK) cell cytotoxicity, interacting with its ligands CD112 and CD155 to initiate immune synapse formation, primarily through leukocyte function-associated-1 (LFA-1). Our study examined the role of CD226 in NK cell surveillance of acute myeloid leukemia (AML). NK cells in patients with AML had lower expression of CD226. CRISPR-Cas9 deletion of CD226 led to reduced LFA-1 recruitment, poor synapse formation, and decreased NK cell anti-leukemic activity. Engineering NK cells to express a chimeric antigen receptor targeting the AML antigen CD38 (CAR38) could overcome the need for CD226 to establish strong immune synapses. LFA-1 blockade reduced CAR38 NK cell activity, and this depended on the CD38 expression levels of AML cells. This suggests parallel but potentially cooperative roles for LFA-1 and CAR38 in synapse formation. Our findings suggest that CAR38 NK cells could be an effective therapeutic strategy to overcome CD226-mediated immune evasion in AML. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-NK+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-NK cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD226%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD226</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Immunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LFA-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LFA-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22acute+myeloid+leukemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">acute myeloid leukemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+synapse%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune synapse</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Killer+Cells%2c+Natural%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Killer Cells, Natural/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Killer+Cells%2c+Natural%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Killer Cells, Natural/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukemia%2c+Myeloid%2c+Acute%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukemia, Myeloid, Acute/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukemia%2c+Myeloid%2c+Acute%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukemia, Myeloid, Acute/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukemia%2c+Myeloid%2c+Acute%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukemia, Myeloid, Acute/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+Differentiation%2c+T-Lymphocyte%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, Differentiation, T-Lymphocyte/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphocyte+Function-Associated+Antigen-1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphocyte Function-Associated Antigen-1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ADP-ribosyl+Cyclase+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ADP-ribosyl Cyclase 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+Evasion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune Evasion</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunological+Synapses%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunological Synapses/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P30 CA016672 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Ma J</b>, To SKY, Fung KSW, Wang K, Zhang J, Ngan AHW, Yung S, Chan TM, Wong CCL, Ip PPC, Peng L, Guo HY, Chan CB, Wong AST. P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115096. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39700008' target='_blank'>39700008</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115096' target='_blank'>10.1016/j.celrep.2024.115096</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115096','39700008', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115096' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/21/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.celrep.2024.115096" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cancer adhesion to the mesothelium is critical for peritoneal metastasis, but how metastatic cells adapt to the biomechanical microenvironment remains unclear. Our study demonstrates that highly metastatic (HM), but not non-metastatic, ovarian cancer cells selectively activate the peritoneal mesothelium. HM cells exert a stronger adhesive force on mesothelial cells via P-cadherin, an adhesion molecule abundant in late-stage tumors. Mechanical activation of P-cadherin enhances lipogenic gene expression and lipid content in HM cells through SREBP1. P-cadherin also induces glycolysis in the interacting mesothelium without affecting lipogenic activity, with the resulting lactate serving as a substrate for lipogenesis in HM cells. Nanodelivery of small interfering RNA (siRNA) targeting P-cadherin or MCT1/4 transporters significantly suppresses metastasis in mice. Moreover, increased fatty acid synthase levels in metastatic patient samples correlate with high P-cadherin expression, supporting enhanced de novo lipogenesis in the metastatic niche. This study reveals P-cadherin-mediated mechano-metabolic coupling as a promising target to restrain metastasis. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22P-cadherin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P-cadherin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22adhesion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">adhesion</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glycolysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glycolysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lipogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lipogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mechanotransduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mechanotransduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metabolic+reprogramming%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metabolic reprogramming</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ovarian+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ovarian cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22peritoneal+metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">peritoneal metastasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumor+mesothelium%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumor mesothelium</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cadherins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cadherins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovarian+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovarian Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovarian+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovarian Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovarian+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovarian Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Metastasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelium%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelium/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelium%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelium/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipogenesis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipogenesis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycolysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycolysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Adhesion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Adhesion</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Nude%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Nude</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Novak J</b>, Nahacka Z, Oliveira GL, Brisudova P, Dubisova M, Dvorakova S, Miklovicova S, Dalecka M, Puttrich V, Grycova L, Magalhaes-Novais S, Correia CM, Levoux J, Stepanek L, Prochazka J, Svec D, Reguera DP, Lopez-Domenech G, Zobalova R, Sedlacek R, Terp MG, Gammage PA, Lansky Z, Kittler J, Oliveira PJ, Ditzel HJ, Berridge MV, Rodriguez AM, Boukalova S, Rohlena J, Neuzil J. The adaptor protein Miro1 modulates horizontal transfer of mitochondria in mouse melanoma models. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115154. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39792553' target='_blank'>39792553</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115154' target='_blank'>10.1016/j.celrep.2024.115154</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115154','39792553', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115154' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/12/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.celrep.2024.115154" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Recent research has shown that mtDNA-deficient cancer cells (ρ0 cells) acquire mitochondria from tumor stromal cells to restore respiration, facilitating tumor formation. We investigated the role of Miro1, an adaptor protein involved in movement of mitochondria along microtubules, in this phenomenon. Inducible Miro1 knockout (Miro1KO) mice markedly delayed tumor formation after grafting ρ0 cancer cells. Miro1KO mice with fluorescently labeled mitochondria revealed that this delay was due to hindered mitochondrial transfer from the tumor stromal cells to grafted B16 ρ0 cells, which impeded recovery of mitochondrial respiration and tumor growth. Miro1KO led to the perinuclear accumulation of mitochondria and impaired mobility of the mitochondrial network. In vitro experiments revealed decreased association of mitochondria with microtubules, compromising mitochondrial transfer via tunneling nanotubes (TNTs) in mesenchymal stromal cells. Here we show the role of Miro1 in horizontal mitochondrial transfer in mouse melanoma models in vivo and its involvement with TNTs. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cell+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cell biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Miro1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Miro1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RHOT1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RHOT1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22horizontal+transfer+of+mitochondria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">horizontal transfer of mitochondria</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22melanoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">melanoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mitochondria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mitochondria</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tunneling+nanotubes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tunneling nanotubes</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melanoma%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melanoma, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melanoma%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melanoma, Experimental/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melanoma%2c+Experimental%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melanoma, Experimental/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microtubules%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microtubules/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondrial+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondrial Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondrial+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondrial Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rho+GTP-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rho GTP-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Joseph S</b>, Zhang X, Droby GN, Wu D, Bae-Jump V, Lyons S, Mordant A, Mills A, Herring L, Rushing B, Bowser JL, Vaziri C. MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115104. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39708320' target='_blank'>39708320</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115104' target='_blank'>10.1016/j.celrep.2024.115104</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115104','39708320', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115104' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/23/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.celrep.2024.115104" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The molecular underpinnings of high-grade endometrial carcinoma (HGEC) metastatic growth and survival are poorly understood. Here, we show that ascites-derived and primary tumor HGEC cell lines in 3D spheroid culture faithfully recapitulate key features of malignant peritoneal effusion and exhibit fundamentally distinct transcriptomic, proteomic, and metabolomic landscapes compared with conventional 2D monolayers. Using a genetic screening platform, we identify MAPK14 (which encodes the protein kinase p38α) as a specific requirement for HGEC in spheroid culture. MAPK14/p38α has broad roles in programming the phosphoproteome, transcriptome, and metabolome of HGEC spheroids, yet has negligible impact on monolayer cultures. MAPK14 promotes tumorigenicity in vivo and is specifically required to sustain a sub-population of spheroid cells that is enriched in cancer stemness markers. Therefore, spheroid growth of HGEC activates unique biological programs, including p38α signaling, that cannot be captured using 2D culture models and are highly relevant to malignant disease pathology. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%223D+spheroids%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">3D spheroids</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CRISPR-Cas9+screen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CRISPR-Cas9 screen</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAPK14%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAPK14</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NDRG1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NDRG1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22endometrial+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">endometrial cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22kinome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">kinome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22p38%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">p38α</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endometrial+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endometrial Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endometrial+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endometrial Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endometrial+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endometrial Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitogen-Activated+Protein+Kinase+14%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitogen-Activated Protein Kinase 14/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitogen-Activated+Protein+Kinase+14%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitogen-Activated Protein Kinase 14/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spheroids%2c+Cellular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spheroids, Cellular/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spheroids%2c+Cellular%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spheroids, Cellular/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinogenesis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinogenesis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinogenesis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinogenesis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinogenesis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinogenesis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Lombardi O</b>, Li R, Jabbar F, Evans H, Halim S, Lima JDCC, Browning L, Byrne HM, Choudhry H, Ratcliffe PJ, Mole DR. Conserved patterns of transcriptional dysregulation, heterogeneity, and cell states in clear cell kidney cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115169. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39792555' target='_blank'>39792555</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115169' target='_blank'>10.1016/j.celrep.2024.115169</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115169','39792555', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115169' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/12/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.celrep.2024.115169" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Clear cell kidney cancers are characterized both by conserved oncogenic driver events and by marked intratumor genetic and phenotypic heterogeneity, which help drive tumor progression, metastasis, and resistance to therapy. How these are reflected in transcriptional programs within the cancer and stromal cell components remains an important question with the potential to drive novel therapeutic approaches to treating cancer. To better understand these programs, we perform single-cell transcriptomics on 75 multi-regional biopsies from kidney tumors and normal kidney. We identify conserved patterns of transcriptional dysregulation and their upstream regulators within the tumor and associated vasculature. We describe recurrent subclonal transcriptional consequences of Chr14q loss linked to metastatic potential. We identify prognostically significant conserved patterns of intratumor transcriptional heterogeneity. These reflect co-existing cell states found in both cancer cells and normal kidney cells, indicating that rather than arising from genetic heterogeneity they are a consequence of lineage plasticity. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Genomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Genomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HIF%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HIF</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22VHL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">VHL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22aneuploidy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">aneuploidy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ccRCC%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ccRCC</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22evolution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">evolution</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22heterogeneity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">heterogeneity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hypoxia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hypoxia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22plasticity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">plasticity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22single-cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">single-cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22transcriptomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">transcriptomics</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Renal+Cell%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Renal Cell/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Renal+Cell%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Renal Cell/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Renal+Cell%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Renal Cell/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Heterogeneity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Heterogeneity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription%2c+Genetic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription, Genetic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcriptome%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcriptome/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Single-Cell+Analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Single-Cell Analysis</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Poluben L</b>, Nouri M, Liang J, Chen S, Varkaris A, Ersoy-Fazlioglu B, Voznesensky O, Lee II, Qiu X, Cato L, Seo JH, Freedman ML, Sowalsky AG, Lack NA, Corey E, Nelson PS, Brown M, Long HW, Russo JW, Balk SP. Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115089. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39709604' target='_blank'>39709604</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115089' target='_blank'>10.1016/j.celrep.2024.115089</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115089','39709604', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(12);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115089' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/24/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.celrep.2024.115089" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Androgen receptor (AR) splice variants, of which ARv7 is the most common, are increased in castration-resistant prostate cancer, but the extent to which they drive AR activity is unclear. We generated a subline of VCaP cells (VCaP16) that is resistant to the AR inhibitor enzalutamide (ENZ). AR activity in VCaP16 is driven by ARv7, independently of full-length AR (ARfl), and its cistrome and transcriptome mirror those of ARfl in VCaP cells. ARv7 expression increases rapidly in response to ENZ, but there is a delay in gaining chromatin binding and transcriptional activity, which is associated with increased chromatin accessibility. AR and nuclear factor I (NFI) motifs are most enriched at more accessible sites, and NFIB/X knockdown greatly diminishes ARv7 function. These findings indicate that ARv7 can drive the AR program but that its activity is dependent on adaptations that increase chromatin accessibility to enhance its intrinsically weak chromatin binding. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Molecular+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Molecular biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FOXA1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FOXA1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22androgen+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">androgen receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chromatin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chromatin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epigenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epigenetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nuclear+factor+I%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nuclear factor I</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prostate+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prostate cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22transcription%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">transcription</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Androgen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Androgen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Androgen%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Androgen/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chromatin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chromatin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NFI+Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NFI Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NFI+Transcription+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NFI Transcription Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenylthiohydantoin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenylthiohydantoin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Benzamides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Benzamides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nitriles%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nitriles/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Isoforms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Isoforms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Isoforms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Isoforms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alternative+Splicing%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alternative Splicing/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P50 CA090381 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P50 CA272390 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Dunlap KN</b>, Bender A, Bowles A, Bott AJ, Tay J, Grossmann AH, Rutter J, Ducker GS. SLC7A5 is required for cancer cell growth under arginine-limited conditions. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115130. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39756034' target='_blank'>39756034</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115130' target='_blank'>10.1016/j.celrep.2024.115130</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115130','39756034', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(13);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115130' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/07/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.celrep.2024.115130" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Tumor cells must optimize metabolite acquisition between synthesis and uptake from a microenvironment characterized by hypoxia, lactate accumulation, and depletion of many amino acids, including arginine. We performed a metabolism-focused functional screen using CRISPR-Cas9 to identify pathways and factors that enable tumor growth in an arginine-depleted environment. Our screen identified the SLC-family transporter SLC7A5 as required for growth, and we hypothesized that this protein functions as a high-affinity citrulline transporter. Using isotope tracing experiments, we show that citrulline uptake and metabolism into arginine are dependent upon expression of SLC7A5. Pharmacological inhibition of SLC7A5 blocks growth under low-arginine conditions across a diverse group of cancer cell lines. Loss of SLC7A5 reduces tumor growth and citrulline import in a mouse tumor model. We identify a conditionally essential role for SLC7A5 in arginine metabolism, and we propose that SLC7A5-targeting therapeutic strategies in cancer may be effective in the context of arginine limitation. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CRISPR+screening%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CRISPR screening</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SLC7A5%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SLC7A5</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22amino+acid+transport%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">amino acid transport</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22arginine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">arginine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer+metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22citrulline%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">citrulline</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arginine%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arginine/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Citrulline%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Citrulline/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amino+Acid+Transport+System+y%2b%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amino Acid Transport System y+/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amino+Acid+Transport+System+y%2b%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amino Acid Transport System y+/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Large+Neutral+Amino+Acid-Transporter+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Large Neutral Amino Acid-Transporter 1</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R37 CA230630 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Zhou B</b>, Zhao Q, Hou G, He J, Sha N, Zheng K, Peng H, Wang W, Zhou Y, Chen T, Jiang Y. IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115116. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39739531' target='_blank'>39739531</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115116' target='_blank'>10.1016/j.celrep.2024.115116</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115116','39739531', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115116' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/02/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.celrep.2024.115116" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Inosine monophosphate dehydrogenase 2 (IMPDH2) is highly expressed in human cancers; however, its physiological relevance under growth signaling remains to be investigated. Here, we show that IMPDH2 serine 122 is phosphorylated by CDK1, and this modification attenuates the catalytic activity of IMPDH2 for IMP oxidation and simultaneously represses its allosteric modulation by purine nucleotides. Fibroblast growth factor receptor (FGFR) signaling activation triggers IMPDH2-Ser122 dephosphorylation mediated by protein phosphatase 2A (PP2A), which is dependent on FGFR3-mediated PPP2R1A-Tyr261 phosphorylation leading to PPP2CA-PPP2R1A-IMPDH2 interactions. In turn, Ser122 dephosphorylation positively modulates IMPDH2 activity and contributes to guanine nucleotide synthesis and purine homeostasis, thereby facilitating S-phase completion and cell proliferation. Accordingly, IMPDH2 dephosphorylation is implicated in FGFR activation-enhanced tumorigenesis, and the low level of IMPDH2-Ser122 phosphorylation predicts the poor prognosis of patients with colorectal cancer. These findings illustrate a regulatory mechanism of purine nucleotide production under FGFR signaling, in which the oncogenic effect of reinforced IMPDH2 activity is underscored. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CDK1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CDK1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FGFR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FGFR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PP2A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PP2A</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22S-phase+progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">S-phase progression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22allosteric+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">allosteric regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22phosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">phosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22purine+homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">purine homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumor+cell+growth.%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumor cell growth.</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%e2%97%bc%e2%97%bc%e2%97%bcIMPDH2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">◼◼◼IMPDH2</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IMP+Dehydrogenase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IMP Dehydrogenase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IMP+Dehydrogenase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IMP Dehydrogenase/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22S+Phase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">S Phase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Phosphatase+2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Phosphatase 2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Nude%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Nude</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Fibroblast+Growth+Factor%2c+Type+3%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Fibroblast Growth Factor, Type 3/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Fibroblast+Growth+Factor%2c+Type+3%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Fibroblast Growth Factor, Type 3/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HEK293+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HEK293 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Fibroblast+Growth+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Fibroblast Growth Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Fu M</b>, Zhang M, Zhang L, Feng Y, Gao C, Xu H, Zhang J, Zhang H, Peng T, Chu Y, Wu Y, Wang P, Ye D, Mao Y, Hua W. Transketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115142. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39792560' target='_blank'>39792560</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115142' target='_blank'>10.1016/j.celrep.2024.115142</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115142','39792560', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115142' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/28/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/12/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1016/j.celrep.2024.115142" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Glioblastoma (GBM) is a highly lethal malignant brain tumor with poor survival rates, and chemoresistance poses a significant challenge to the treatment of patients with GBM. Here, we show that transketolase (TKT), a metabolic enzyme in the pentose phosphate pathway (PPP), attenuates the chemotherapy sensitivity of glioma cells in a manner independent of catalytic activity. Mechanistically, chemotherapeutic drugs can facilitate the translocation of TKT protein from the cytosol into the nucleus, where TKT physically interacts with XRN2 to regulate the resolution and removal of R-loops. Depletion of TKT leads to increased R-loop accumulation and genome instability, increasing the susceptibility of glioma cells to chemotherapy. In conclusion, our study reveals a non-metabolic function of TKT in regulating R-loop dynamics, genome instability, and chemotherapy sensitivity in gliomas. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22R-loops%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R-loops</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TKT%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TKT</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chemotherapy+sensitivity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chemotherapy sensitivity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glioma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glioma</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transketolase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transketolase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transketolase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transketolase/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioma%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioma/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioma%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioma/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioma%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioma/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioma%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioma/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistance%2c+Neoplasm%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistance, Neoplasm/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genomic+Instability%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genomic Instability/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Licón-Muñoz Y</b>, Avalos V, Subramanian S, Granger B, Martinez F, García-Montaño LA, Varela S, Moore D, Perkins E, Kogan M, Berto S, Chohan MO, Bowers CA, Piccirillo SGM. Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115149. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39752252' target='_blank'>39752252</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115149' target='_blank'>10.1016/j.celrep.2024.115149</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115149','39752252', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115149' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/11/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1016/j.celrep.2024.115149" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The sub-ventricular zone (SVZ) is the most well-characterized neurogenic area in the mammalian brain. We previously showed that in 65% of patients with glioblastoma (GBM), the SVZ is a reservoir of cancer stem-like cells that contribute to treatment resistance and the emergence of recurrence. Here, we build a single-nucleus RNA-sequencing-based microenvironment landscape of the tumor mass and the SVZ of 15 patients and two histologically normal SVZ samples as controls. We identify a ZEB1-centered mesenchymal signature in the tumor cells of the SVZ. Moreover, the SVZ microenvironment is characterized by tumor-supportive microglia, which spatially coexist and establish crosstalks with tumor cells. Last, differential gene expression analyses, predictions of ligand-receptor and incoming/outgoing interactions, and functional assays reveal that the interleukin (IL)-1β/IL-1RAcP and Wnt-5a/Frizzled-3 pathways represent potential therapeutic targets in the SVZ. Our data provide insights into the biology of the SVZ in patients with GBM and identify potential targets of this microenvironment. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22brain+tumors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">brain tumors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer+stem-like+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer stem-like cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glioblastoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glioblastoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sub-ventricular+zone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sub-ventricular zone</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumor+microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumor microenvironment</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioblastoma%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioblastoma/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioblastoma%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioblastoma/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioblastoma%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioblastoma/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Nucleus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Nucleus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zinc+Finger+E-box-Binding+Homeobox+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zinc Finger E-box-Binding Homeobox 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zinc+Finger+E-box-Binding+Homeobox+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zinc Finger E-box-Binding Homeobox 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wnt-5a+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wnt-5a Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wnt-5a+Protein%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wnt-5a Protein/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-1beta%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-1beta/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lateral+Ventricles%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lateral Ventricles/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lateral+Ventricles%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lateral Ventricles/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplastic+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplastic Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplastic+Stem+Cells%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Bandola-Simon J</b>, Ito Y, Wucherpfennig KW, Roche PA. Defective removal of invariant chain peptides from MHC class II suppresses tumor antigen presentation and promotes tumor growth. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115150. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39752250' target='_blank'>39752250</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115150' target='_blank'>10.1016/j.celrep.2024.115150</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115150','39752250', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115150' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/01/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1016/j.celrep.2024.115150" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Tumor-draining lymph node dendritic cells (DCs) are poor stimulators of tumor antigen-specific CD4 T cells; however, the mechanism behind this defect is unclear. We now show that, in tumor-draining lymph node DCs, a large proportion of major histocompatibility complex class II (MHC-II) molecules retains the class II-associated invariant chain peptide (CLIP) fragment of the invariant chain bound to the MHC-II peptide binding groove due to reduced expression of the peptide editor H2-M and enhanced activity of the CLIP-generating proteinase cathepsin S. The net effect of this is that MHC-II molecules are unable to efficiently bind antigenic peptides. DCs in mice expressing a mutation in the invariant chain sequence that results in enhanced MHC-II-CLIP accumulation are poor stimulators of CD4 T cells and have diminished anti-tumor responses. Our data reveal a previously unknown mechanism of immune evasion in which enhanced expression of MHC-II-CLIP complexes on tumor-draining lymph node DCs limits MHC-II availability for tumor peptides. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CLIP%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CLIP</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Immunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MHC+class+II%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MHC class II</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antigen+presentation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antigen presentation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22dendritic+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">dendritic cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22invariant+chain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">invariant chain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumor+immunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumor immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumor-draining+lymph+node%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumor-draining lymph node</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; 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padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Zhang D</b>, Jiang M, Li P, Laster KV, Zhao D, Zhi Y, Wei H, Nie W, Gao Y, Wu Q, Xiang P, He X, Liu K, Dong Z. CHI-KAT8i5 suppresses ESCC tumor growth by inhibiting KAT8-mediated c-Myc stability. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115135. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39772391' target='_blank'>39772391</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115135' target='_blank'>10.1016/j.celrep.2024.115135</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115135','39772391', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115135' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/11/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.celrep.2024.115135" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The integrated analysis of histone modifier enzymes in solid tumors, especially in esophageal squamous cell carcinoma (ESCC), is still inadequate. Here, we investigate the expression levels of histone modifier enzymes in ESCC tissues. Notably, KAT8 (lysine acetyltransferase 8) is identified as a prognostic and therapeutic biomarker in ESCC. Esophageal-tissue-specific deletion of KAT8 in mice led to less tumor burden after induction of tumorigenesis via 4-nitroquinoline N-oxide (4NQO) treatment compared with wild-type mice. Meanwhile, silencing KAT8 significantly suppresses tumor growth in cell-line-derived xenograft (CDX) and patient-derived xenograft (PDX) models. Mechanically, we confirm that KAT8 regulates c-Myc protein stability by directly binding it. Furthermore, we design and screen a specific KAT8 inhibitor (CHI-KAT8i5) that significantly attenuates tumor growth in vitro and in vivo, providing promising potential for clinical application. Thus, our work identifies that KAT8 could serve as a potential clinically relevant biomarker and therapeutic target in patients with ESCC and that KAT8 inhibitor is a promising lead candidate for ESCC therapy. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22KAT8%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">KAT8</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22c-Myc%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">c-Myc</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22esophageal+squamous+cell+carcinoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">esophageal squamous cell carcinoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22histone+modifications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">histone modifications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inhibitor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inhibitor</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histone+Acetyltransferases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histone Acetyltransferases/metabolism</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Esophageal+Squamous+Cell+Carcinoma%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Esophageal Squamous Cell Carcinoma/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Esophageal+Squamous+Cell+Carcinoma%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Esophageal Squamous Cell Carcinoma/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Li G</b>, Wen Z, Xiong S. Microenvironmental β-TrCP negates amino acid transport to trigger CD8<sup>+</sup> T cell exhaustion in human non-small cell lung cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115128. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39754718' target='_blank'>39754718</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115128' target='_blank'>10.1016/j.celrep.2024.115128</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115128','39754718', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115128' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/06/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1016/j.celrep.2024.115128" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">CD8+ T cell exhaustion (Tex) has been widely acknowledged in human cancer, while the underlying mechanisms remain unclear. Here, we demonstrate that reduced amino acid (aa) metabolism and mTOR inactivation are accountable for Tex in human non-small cell lung cancer (NSCLC). NSCLC cells impede the T cell-intrinsic transcription of SLC7A5 and SLC38A1, disrupting aa transport and consequently leading to mTOR inactivation. Further, the ubiquitination of YAP1 protein is the basis for NSCLC-mediated transcriptional inhibition of aa transporters. Mechanistically, NSCLC cells transfer β-TrCP-containing exosomes into T cells, inducing YAP1 ubiquitination and Tex. Consequently, inhibiting cancer-associated β-TrCP effectively restores the anti-tumor immune response of CD8+ T cells and curtails tumor growth in NSCLC patient-derived organoids. Together, our findings highlight a β-TrCP-dependent mechanism in steering intrinsic metabolic adaptation and CD8+ Tex, emphasizing microenvironmental β-TrCP as an immune checkpoint for therapeutic exploration against human NSCLC. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Immunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NSCLC%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NSCLC</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T+cell+exhaustion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T cell exhaustion</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22amino+acid+transport%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">amino acid transport</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%ce%b2-TrCP%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">β-TrCP</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Non-Small-Cell+Lung%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Non-Small-Cell Lung/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Non-Small-Cell+Lung%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Non-Small-Cell Lung/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Non-Small-Cell+Lung%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Non-Small-Cell Lung/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD8-Positive+T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD8-Positive T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD8-Positive+T-Lymphocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD8-Positive T-Lymphocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22beta-Transducin+Repeat-Containing+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">beta-Transducin Repeat-Containing Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amino+Acids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amino Acids/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22YAP-Signaling+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">YAP-Signaling Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ubiquitination%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ubiquitination</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biological+Transport%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biological Transport</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Cell+Exhaustion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Cell Exhaustion</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Ricci JE</b>. Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115206. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39798090' target='_blank'>39798090</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115206' target='_blank'>10.1016/j.celrep.2024.115206</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115206','39798090', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115206' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/15/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.celrep.2024.115206" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Metabolic reprogramming in both immune and cancer cells plays a crucial role in the antitumor immune response. Recent studies indicate that cancer metabolism not only sustains carcinogenesis and survival via altered signaling but also modulates immune cell function. Metabolic crosstalk within the tumor microenvironment results in nutrient competition and acidosis, thereby hindering immune cell functionality. Interestingly, immune cells also undergo metabolic reprogramming that enables their proliferation, differentiation, and effector functions. This review highlights the regulation of antitumor immune responses through metabolic reprogramming in cancer and immune cells and explores therapeutic strategies that target these metabolic pathways in cancer immunotherapy, including using chimeric antigen receptor (CAR)-T cells. We discuss innovative combinations of immunotherapy, cellular therapies, and metabolic interventions that could optimize the efficacy of existing treatment protocols. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antitumor+activity+of+immune+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antitumor activity of immune cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22therapeutic+strategies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">therapeutic strategies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumor+microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumor microenvironment</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunosuppression+Therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunosuppression Therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+Tolerance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune Tolerance</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Ramakrishnan G</b>, Terry AR, Nogueira V, Magdy A, Hay N. Deletion of AMP-activated protein kinase impairs metastasis and is rescued by ROS scavenging or ectopic CD36 expression. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115183. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39798092' target='_blank'>39798092</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115183' target='_blank'>10.1016/j.celrep.2024.115183</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115183','39798092', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115183' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/15/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1016/j.celrep.2024.115183" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">AMPK's role in tumor initiation and progression is controversial. Here, we provide genetic evidence that AMPK is required for metastasis in mouse models of breast cancer. In a mouse model of spontaneous breast cancer metastasis, the deletion of AMPK before and after tumor onset decreased breast cancer metastasis, and similar results were obtained after AMPK deletion in breast cancer cell lines. The deletion of AMPK induces reactive oxygen species (ROS) levels in vitro and lipid oxidation in vivo, which likely impede metastasis. Indeed, antioxidants restore the ability of AMPK-deficient tumors to metastasize. By inhibiting acetyl-coenzyme A (CoA) carboxylases 1 and 2, AMPK maintains NADPH levels by reducing NADPH consumption in fatty acid synthesis and increasing NADPH generation via fatty acid oxidation, thus increasing the dependency on auxotrophic fatty acids. Consistently, AMPK is required for the expression of the fatty acid transporter CD36 in tumors, and ectopic expression of CD36 in AMPK-deficient cells restored their ability to metastasize. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AMPK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AMPK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD36%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD36</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22breast+cancer+metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">breast cancer metastasis</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD36+Antigens%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD36 Antigens/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD36+Antigens%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD36 Antigens/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AMP-Activated+Protein+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AMP-Activated Protein Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Metastasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Acids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Acids/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Deletion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Deletion</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acetyl-CoA+Carboxylase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acetyl-CoA Carboxylase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acetyl-CoA+Carboxylase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acetyl-CoA Carboxylase/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NADP%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NADP/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidation-Reduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidation-Reduction</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Pozzo E</b>, Yedigaryan L, Giarratana N, Wang CC, Garrido GM, Degreef E, Marini V, Rinaldi G, van der Veer BK, Sassi G, Eelen G, Planque M, Fanzani A, Koh KP, Carmeliet P, Yustein JT, Fendt SM, Uyttebroeck A, Sampaolesi M. miR-449a/miR-340 reprogram cell identity and metabolism in fusion-negative rhabdomyosarcoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115171. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39799567' target='_blank'>39799567</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115171' target='_blank'>10.1016/j.celrep.2024.115171</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115171','39799567', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115171' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/15/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1016/j.celrep.2024.115171" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma, arises in skeletal muscle and remains in an undifferentiated state due to transcriptional and post-transcriptional regulators. Among its subtypes, fusion-negative RMS (FN-RMS) accounts for the majority of diagnoses in the pediatric population. MicroRNAs (miRNAs) are non-coding RNAs that modulate cell identity via post-transcriptional regulation of messenger RNAs (mRNAs). In this study, we identify miRNAs impacting FN-RMS cell identity, revealing miR-449a and miR-340 as major regulators of the cell cycle and p53 signaling. Through miR-eCLIP technology, we demonstrate that miR-449a and miR-340 directly target transcripts involved in glycolysis and mitochondrial pyruvate transport, inhibiting the mitochondrial pyruvate carrier (MPC) complex. Pharmacological MPC inhibition induces a similar metabolic shift, reducing metastatic potential and leading to cell cycle exit. Overall, miR-449 and miR-340 orchestrate FN-RMS cell identity, positioning MPC inhibition as a strategy to shift FN-RMS cells toward a non-tumorigenic, quiescent state. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22UK-5099%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">UK-5099</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+identity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell identity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miRNAs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miRNAs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mitochondrial+pyruvate+carrier%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mitochondrial pyruvate carrier</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pediatric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pediatric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rhabdomyosarcoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rhabdomyosarcoma</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rhabdomyosarcoma%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rhabdomyosarcoma/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rhabdomyosarcoma%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rhabdomyosarcoma/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rhabdomyosarcoma%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rhabdomyosarcoma/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycolysis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycolysis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Suppressor+Protein+p53%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Suppressor Protein p53/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Suppressor+Protein+p53%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Suppressor Protein p53/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Cycle%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Cycle/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Monocarboxylic+Acid+Transporters%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Monocarboxylic Acid Transporters/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Monocarboxylic+Acid+Transporters%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Monocarboxylic Acid Transporters/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellular+Reprogramming%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellular Reprogramming/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Boulton DP</b>, Hughes CJ, Vaira V, Del Gobbo A, Palleschi A, Locatelli M, Danis E, Raza M, Neumann AJ, Purdy SC, Lerma R, Meshki J, Ford HL, Prekeris R, Morrissey C, Caino MC. MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115120. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39723893' target='_blank'>39723893</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115120' target='_blank'>10.1016/j.celrep.2024.115120</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115120','39723893', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(23);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115120' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/28/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.celrep.2024.115120" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Metastasis to vital organs remains the leading cause of cancer-related deaths, emphasizing an urgent need for actionable targets in advanced-stage cancer. The role of mitochondrial Rho GTPase 2 (MIRO2) in prostate cancer growth was recently reported; however, whether MIRO2 is important for additional steps in the metastatic cascade is unknown. Here, we show that knockdown of MIRO2 ubiquitously reduces tumor cell invasion in vitro and suppresses metastatic burden in prostate and breast cancer mouse models. Mechanistically, depletion of MIRO2's binding partner-unconventional myosin 9B (MYO9B)-reduces tumor cell invasion and phenocopies MIRO2 depletion, which in turn results in increased active RhoA. Furthermore, dual ablation of MIRO2 and RhoA fully rescues tumor cell invasion, and MIRO2 is required for MYO9B-driven invasion. Taken together, we show that MIRO2 supports invasion and metastasis through cooperation with MYO9B, underscoring a potential targetable pathway for patients with advanced disease. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Molecular+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Molecular biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MIRO2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MIRO2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MYO9B%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MYO9B</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RhoA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RhoA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metastasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22small+GTPases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">small GTPases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumor+cell+invasion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumor cell invasion</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rhoA+GTP-Binding+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rhoA GTP-Binding Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Invasiveness%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Invasiveness</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Metastasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myosins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myosins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostatic+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostatic Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rho+GTP-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rho GTP-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Movement%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Movement</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondrial+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondrial Proteins</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">F31 CA271652 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIGMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R35 GM142774 NIGMS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIGMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T32 GM136444 NIGMS NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Zhou L</b>, Yu L, Song S, Wang Y, Zhu Q, Li M, Sha Y, Xu L, Shu X, Liao Q, Wu T, Yang B, Chai S, Lin B, Wu L, Zhou R, Duan X, Zhu C, Ruan Y, Yi W. Mina53 catalyzes arginine demethylation of p53 to promote tumor growth. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115242. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39864061' target='_blank'>39864061</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2025.115242' target='_blank'>10.1016/j.celrep.2025.115242</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2025.115242','39864061', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2025.115242' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/08/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/28/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1016/j.celrep.2025.115242" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Arginine methylation is a common post-translational modification that plays critical roles in many biological processes. However, the existence of arginine demethylases that remove the modification has not been fully established. Here, we report that Myc-induced nuclear antigen 53 (Mina53), a member of the jumonji C (JmjC) protein family, is an arginine demethylase. Mina53 catalyzes the removal of asymmetric dimethylation at arginine 337 of p53. Mina53-mediated demethylation reduces p53 stability and oligomerization and alters chromatin modifications at the gene promoter, thereby suppressing p53-mediated transcriptional activation and cell-cycle arrest. Mina53 represses p53-dependent tumor suppression both in mouse xenografts and spontaneous tumor models. Moreover, downregulation of p53-mediated gene expression is observed in several types of cancer with elevated expression of Mina53. Thus, our study reveals a regulatory mechanism of p53 homeostasis and activity and, more broadly, defines a paradigm for dynamic arginine methylation in controlling important biological functions. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Molecular+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Molecular biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mina53%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mina53</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22arginine+demethylase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">arginine demethylase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22arginine+methylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">arginine methylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gene+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gene regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22p53%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">p53</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22p53+signaling+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">p53 signaling pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumor+growth%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumor growth</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Mosley SR</b>, Chen A, Doell DNW, Choi S, Mowat C, Meier-Stephenson F, Meier-Stephenson V, Baker K. Cytosolic DNA composition is determined by genomic instability mechanism and regulates dendritic cell-mediated anti-tumor immunity. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2025;<b>44</b>:115177. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39864057' target='_blank'>39864057</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2024.115177' target='_blank'>10.1016/j.celrep.2024.115177</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2024.115177','39864057', 'CP: Cancer')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.celrep.2024.115177' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/28/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1016/j.celrep.2024.115177" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Patients with colorectal cancers (CRCs) that have microsatellite instability (MSI) (MSI CRCs) face a better prognosis than those with the more common chromosomal instability (CIN) subtype (CIN CRCs) due to improved T cell-mediated anti-tumor immune responses. Previous investigations identified the cytosolic DNA (cyDNA) sensor STING as necessary for chemokine-mediated T cell recruitment in MSI CRCs. Here, we find that cyDNA from MSI CRC cells is inherently more capable of inducing STING activation and improves cytotoxic T cell activation by dendritic cells (DCs). Sequencing indicates that MSI cyDNA is enriched in microsatellites, which, upon DC uptake, induce anti-tumor immunity in a manner consistent with clinical MSI CRCs. DNA-damaging therapies also modulate cyDNA stimulation capacity, with radiation inducing larger cyDNA sizes and increased mitochondrial DNA content. Identifying highly stimulatory endogenous cyDNAs such as those in MSI CRCs will allow for optimized development of DNA-based STING agonist therapies to improve the responses of CIN CRCs with CIN to immunotherapies. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CP%3a+Immunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP: Immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+repair%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA repair</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anti-tumor+immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anti-tumor immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cGAS%2fSTING+signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cGAS/STING signaling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22colorectal+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">colorectal cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22dendritic+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">dendritic cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genomic+instability%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genomic instability</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(25);" 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</div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">CP: Cancer (578 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="578" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">CP: Cancer (578 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="578" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>