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Novel causative variants in <span class="highlight-field">Legius syndrome</span>: SPRED1 Genotype spectrum expansion. <em class='incite-journal-name' onclick='ShowInCiteJournal(168570);'>Am J Med Genet A</em> 2024;<b>194</b>:e63824. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39031930' target='_blank'>39031930</a> DOI: <a href='https://dx.doi.org/10.1002/ajmg.a.63824' target='_blank'>10.1002/ajmg.a.63824</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/ajmg.a.63824','39031930', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/ajmg.a.63824' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168570);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1002/ajmg.a.63824" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Legius syndrome, commonly referred to as SPRED1-related neurofibromatosis type 1-like syndrome, is a rare autosomal dominant disorder characterized by café-au-lait macules, freckling, lipomas, macrocephaly, and heterogeneous neurodevelopmental manifestations, including a different degree of learning difficulties. Although a partial clinical overlap exists with neurofibromatosis type 1 (NF1), Legius syndrome is distinguished by its genetic etiology and the absence of neurofibromas, indicating an inherent lack of tumor risk. The SPRED1 gene encodes the Sprouty-related protein with an EVH1 domain 1 (SPRED1), a negative regulator of the RAS-MAPK signaling pathway with a crucial role in cellular growth and development. Despite various genetic variants and genomic deletions associated with Legius syndrome, the full genetic spectrum of this condition remains elusive. In this study, we investigated the underlying genetic etiology in a cohort of patients presenting with typical manifestations of Legius syndrome using a custom Next Generation Sequencing (NGS) panel and Multiplex Ligation-Dependent Probe Amplification (MLPA) for NF1 and SPRED1. We identified 12 novel SPRED1 damaging variants segregating with the phenotype in all families. These rare variants affect conserved residues of the protein and are predicted damaging according to in silico tools. No clear genotype-phenotype correlations could be observed in the current cohort and previously reported patients, underscoring the heterogeneous genotype spectrum of this condition. Our findings expand the understanding of SPRED1 variants causing Legius syndrome and underscore the importance of comprehensively characterizing the genetic landscape of this disorder. Despite the absence of clear genotype-phenotype correlations, elucidating the genetic etiology of Legius syndrome is pertinent for facilitating accurate diagnosis, genetic counseling, and therapeutic interventions. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAS%e2%80%90MAPK+signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAS‐MAPK signaling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SPRED1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SPRED1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caf%c3%a9%e2%80%90au%e2%80%90lait+macules%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">café‐au‐lait macules</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22freckling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">freckling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+type+1%e2%80%90like+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis type 1‐like syndrome</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-Lait+Spots%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cafe-au-Lait Spots/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-Lait+Spots%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cafe-au-Lait Spots/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Predisposition+to+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Predisposition to Disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pedigree%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pedigree</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Association+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Association Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22High-Throughput+Nucleotide+Sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">High-Throughput Nucleotide Sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Hirata Y</b>, Brems H, Van der Auweraer S, Ohyagi M, Iizuka M, Mise-Omata S, Ito M, Messiaen L, Mizuno S, Takahashi S, Legius E, Yoshimura A. <span class="highlight-field">Legius Syndrome</span> mutations in the Ras-regulator SPRED1 abolish its membrane localization and potentially cause neurodegeneration. <em class='incite-journal-name' onclick='ShowInCiteJournal(12370);'>J Biol Chem</em> 2024:107969. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39510187' target='_blank'>39510187</a> DOI: <a href='https://dx.doi.org/10.1016/j.jbc.2024.107969' target='_blank'>10.1016/j.jbc.2024.107969</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jbc.2024.107969','39510187', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jbc.2024.107969' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12370);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/15/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.jbc.2024.107969" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The SPRED family proteins act as negative regulators of the Ras-ERK pathway: the N-terminal EVH1 domain interacts with the Ras-GAP domain (GRD) of the NF1 protein, while the C-terminal Sprouty-related (SPR) domain promotes membrane localization of SPRED, thereby recruiting NF-1 to Ras. Loss-of-function mutations in the hSPRED1 cause Legius syndrome in an autosomal dominant manner. In this study, we investigated the effects of missense mutations in the SPR domain identified in patients with Legius syndrome. Among 18 mutations we examined, six (C368S, M369L, V408E, P415A, P415L and P422R) have defects in the palmitoylation of the SPRED1 protein, losing plasma membrane localization and forming cytoplasmic granular aggregates. To evaluate the in vivo effects of SPR mutations, knock-in (KI) mice with P415A and P415V substitutions or M417Afs*4, a C-terminal 28 amino acid deletion, were generated. All these KI mice exhibited cranial malformations, a characteristic feature of Legius syndrome. However, both P415A and P415V mutants formed granular aggregates, whereas M417Afs*4 showed a diffuse cytoplasmic distribution, and Spred1P415A and Spred1P415V mice, but not Spred1M417Afs∗4 mice, developed cerebellar ataxia and Purkinje cell loss with age. These data suggest that in addition to loss of palmitoylation, the C-terminal region is required for the granular aggregate formation and Purkinje cell loss. The autophagy inducer spermidine rescued the ataxia phenotypes and Purkinje cell loss in Spred1P415A mice. These results suggest that some, but not all, SPR mutations that lose lipid modification induce abnormal cytoplasmic aggregation, which could be a target for autophagic clearance, and potentially cause neurodegenerative diseases. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SPRED1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SPRED1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22membrane+localization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">membrane localization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurodegeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurodegeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22palmitoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">palmitoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22spermidine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">spermidine</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Medina Lemus A</b>, Boelman C, Myers KA. Epilepsy in <span class="highlight-field">Legius syndrome</span>: Coincidence or causation? <em class='incite-journal-name' onclick='ShowInCiteJournal(168570);'>Am J Med Genet A</em> 2024;<b>194</b>:e63547. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38268057' target='_blank'>38268057</a> DOI: <a href='https://dx.doi.org/10.1002/ajmg.a.63547' target='_blank'>10.1002/ajmg.a.63547</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/ajmg.a.63547','38268057', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(3);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/ajmg.a.63547' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168570);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/03/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/26/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1002/ajmg.a.63547" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Legius syndrome is a rare genetic disorder, caused by heterozygous SPRED1 pathogenic variants, which shares phenotypic features with neurofibromatosis type 1 (NF1). Both conditions typically involve café-au-lait macules, axillary freckling, and macrocephaly; however, patients with NF1 are also at risk for tumors, such as optic nerve gliomas and neurofibromas. Seizure risk is known to be elevated in NF1, but there has been little study of this aspect of Legius syndrome. The reported epilepsy incidence is 3.3%-5%, well above the general population incidence of ~0.5%-1%, but the few reports in the literature have very little data regarding epilepsy phenotype. We identified two unrelated individuals, both with Legius syndrome and epilepsy, and performed thorough phenotyping. One individual's mother also had Legius syndrome and now-resolved childhood epilepsy, as well as reports of more distant relatives who also had multiple café-au-lait macules and seizures. Both probands had experienced childhood-onset focal seizures, with normal brain MRI. In one patient, EEG later showed apparently generalized epileptiform abnormalities. Based on the data from this small case series and literature review, seizure risk is increased in people with Legius syndrome, but the epilepsy prognosis appears to be generally good, with patients having either self-limited or pharmacoresponsive courses. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epilepsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epilepsy</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fonds+de+Recherche+du+Qu%c3%a9bec+-+Sant%c3%a9%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fonds de Recherche du Québec - Santé</a></li></ul> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> How common are ear, nose and throat disorders in children with Noonan syndrome and other RASopathies? <em class='incite-journal-name' onclick='ShowInCiteJournal(11757);'>Int J Pediatr Otorhinolaryngol</em> 2023;<b>166</b>:111480. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36764080' target='_blank'>36764080</a> DOI: <a href='https://dx.doi.org/10.1016/j.ijporl.2023.111480' target='_blank'>10.1016/j.ijporl.2023.111480</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ijporl.2023.111480','36764080', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ijporl.2023.111480' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11757);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/ijporl/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/18/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/31/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/04/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/09/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.ijporl.2023.111480" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">INTRODUCTION</div><div class="abstract-content">Noonan syndrome and related conditions (RASopathies) are known to be associated with abnormalities in many organ systems. It is our impression that few otolaryngologists are familiar with the manifestations of these syndromes and we therefore reviewed our hospital's patient cohort to identify the prevalence of ear, nose and throat disorders in these children.</div><div class="abstract-label">METHODS</div><div class="abstract-content">We cross-referenced various hospital department databases (otolaryngology, audiology, cardiology, haematology and genetics) to try to identify as many children with Noonan and other RASopathies as possible. We then performed a retrospective review of electronic patient records.</div><div class="abstract-label">RESULTS</div><div class="abstract-content">We identified 67 children with Noonan, Costello, LEOPARD and other RASopathy syndromes. Around half have been seen in otolaryngology and audiology clinics. Otitis media with effusion requiring ventilation tubes occurred in 4% of children. 10% have suffered recurrent acute otitis media. 9% have a sensorineural hearing loss. 7% have undergone adenotonsillectomy for obstructive sleep apnoea. Airway anomalies and head and neck malformations occur but are rare.</div><div class="abstract-label">DISCUSSION</div><div class="abstract-content">Children with Noonan and other RASopathies present commonly to otolaryngology and audiology clinics. The prevalence of sensorineural hearing loss is high and audiological screening is likely to be worthwhile. Surgeons should be aware that complications of surgery are common and can be very severe, especially in those with cardiac anomalies.</div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Children%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Children</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Costello+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Costello syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Head+and+neck+anomalies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Head and neck anomalies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hearing+disorders%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hearing disorders</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LEOPARD+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LEOPARD syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Laryngeal+anomalies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Laryngeal anomalies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+sydrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan sydrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obstructive+sleep+apnoea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obstructive sleep apnoea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Otitis+media%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Otitis media</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Otolaryngology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Otolaryngology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rhinosinusitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rhinosinusitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tonsillitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tonsillitis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tracheal+anomalies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tracheal anomalies</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> Neurofibromatosis type 1: A comparison of the 1997 NIH and the 2021 revised diagnostic criteria in 75 children and adolescents. <em class='incite-journal-name' onclick='ShowInCiteJournal(168870);'>Genet Med</em> 2022;<b>24</b>:1978-1985. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35713653' target='_blank'>35713653</a> DOI: <a href='https://dx.doi.org/10.1016/j.gim.2022.05.013' target='_blank'>10.1016/j.gim.2022.05.013</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.gim.2022.05.013','35713653', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.gim.2022.05.013' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168870);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/10/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/19/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/23/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/21/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.gim.2022.05.013" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">PURPOSE</div><div class="abstract-content">Examining a cohort of patients suspicious of neurofibromatosis type 1 (NF1) we compared the revised diagnostic criteria with the previous National Institutes of Health (NIH) diagnostic criteria. We asked whether the refinement improved distinguishing between NF1, Legius syndrome, and constitutional mismatch repair deficiency (CMMRD).</div><div class="abstract-label">METHODS</div><div class="abstract-content">A database search in the hospital information system of the University Children's Hospital Augsburg between 2017 and 2020 ascertained patients with International Classification of Diseases-10 code Q85.0; their clinical phenotype was evaluated by retrospective chart review.</div><div class="abstract-label">RESULTS</div><div class="abstract-content">A total of 75 patients were identified (median age 11.0 years [range 1.1-22.6 years]; 35 female). At first suspicion of NF1, 44 patients met the NIH criteria and 56 met the revised diagnostic criteria. In total, 12 patients were diagnosed with NF1 after performing molecular genetic testing. In 31 patients, only pigmentary findings were present, whereas nonpigmentary NF1 manifestations presented with time in 9 patients. In 1 patient a heterozygous variant of uncertain significance was identified in SPRED1. Requirements for CMMRD testing were fulfilled in another patient. A total of 3 patients presented with segmental clinical findings. Three additional patients did not meet the NIH criteria, 1 of them presented with 1 additional feature of CMMRD without fulfilling requirements for testing.</div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">In our pediatric cohort, the revised diagnostic criteria discovered more patients with proven NF1 than the NIH criteria.</div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Constitutional+mismatch+repair+deficiency%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Constitutional mismatch repair deficiency</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Institutes+of+Health+diagnostic+criteria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Institutes of Health diagnostic criteria</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Revised+diagnostic+criteria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Revised diagnostic criteria</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Albaghdadi M</b>, Berseneva M, Pennal A, Wan S, Matviychuk D, Shugar A, Kannu P, Lara-Corrales I. Value of a café-au-lait macules screening clinic: Experience from The Hospital for Sick Children in Toronto. <em class='incite-journal-name' onclick='ShowInCiteJournal(18805);'>Pediatr Dermatol</em> 2022;<b>39</b>:205-210. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35178768' target='_blank'>35178768</a> DOI: <a href='https://dx.doi.org/10.1111/pde.14947' target='_blank'>10.1111/pde.14947</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/pde.14947','35178768', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/pde.14947' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18805);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://wiley.atyponrex.com/dashboard?siteName=PDE' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/30/2022]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1111/pde.14947" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND/OBJECTIVES</div><div class="abstract-content">Café-au-lait macules (CALMs) are a characteristic feature of neurofibromatosis type 1 (NF1), but also occur in other genetic disorders. Differential diagnosis of CALMs remains challenging and can be stressful for families. We sought to examine the role of an established CALMs screening clinic in diagnosing CALMs-related disorders.</div><div class="abstract-label">METHOD</div><div class="abstract-content">We retrospectively reviewed patients seen between July 2012 and January 2019 in a CALMs screening clinic at The Hospital for Sick Children, a tertiary pediatric hospital in Toronto, Canada. Pediatric patients were referred because of multiple CALMs or suspected NF1. Selection was based on a chronological referral sample with no exclusions. A pediatric dermatologist examined all patients for CALMs and NF1 manifestations. Genetic testing was offered to confirm a clinical diagnosis or when clinical findings were inconclusive.</div><div class="abstract-label">RESULTS</div><div class="abstract-content">Three hundred patients, of which 152 (50.7%) were female and had a mean age of 5.6 ± 4.8 years were seen during the study period. NF1 was diagnosed in 76 (25.3%) patients, mosaic NF1 in 38 (12.7%) patients, and 8 (2.7%) patients received other genetic diagnoses. One hundred and twelve (37.3%) patients were diagnosed with isolated CALMs not associated with an underlying genetic disease. Furthermore, 36 (12%) of our patients did not have CALMs.</div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">The CALMs screening clinic aided in the early diagnosis of genetic disorders such as NF1 and distinguished CALMs from other hyperpigmented lesions. We encourage the adoption of this clinic model in referral centers to streamline and optimize care of patients with presumptive diagnosis of CALMs.</div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurocutaneous+syndromes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurocutaneous syndromes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caf%c3%a9+au-lait+macules%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">café au-lait macules</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mosaicism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mosaicism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis 1</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Hebron KE</b>, Hernandez ER, Yohe ME. The RASopathies: from pathogenetics to therapeutics. <em class='incite-journal-name' onclick='ShowInCiteJournal(7809);'>Dis Model Mech</em> 2022;<b>15</b>:274419. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35178568' target='_blank'>35178568</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862741' target='_blank'>PMC8862741</a> DOI: <a href='https://dx.doi.org/10.1242/dmm.049107' target='_blank'>10.1242/dmm.049107</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1242%2fdmm.049107%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 51</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1242%2fdmm.049107')">Impact Index Per Article: 25.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1242/dmm.049107','35178568', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1242/dmm.049107' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1242/dmm.049107');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7809);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/21/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1242/dmm.049107" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The RASopathies are a group of disorders caused by a germline mutation in one of the genes encoding a component of the RAS/MAPK pathway. These disorders, including neurofibromatosis type 1, Noonan syndrome, cardiofaciocutaneous syndrome, Costello syndrome and Legius syndrome, among others, have overlapping clinical features due to RAS/MAPK dysfunction. Although several of the RASopathies are very rare, collectively, these disorders are relatively common. In this Review, we discuss the pathogenesis of the RASopathy-associated genetic variants and the knowledge gained about RAS/MAPK signaling that resulted from studying RASopathies. We also describe the cell and animal models of the RASopathies and explore emerging RASopathy genes. Preclinical and clinical experiences with targeted agents as therapeutics for RASopathies are also discussed. Finally, we review how the recently developed drugs targeting RAS/MAPK-driven malignancies, such as inhibitors of RAS activation, direct RAS inhibitors and RAS/MAPK pathway inhibitors, might be leveraged for patients with RASopathies.</div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardiofaciocutaneous+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardiofaciocutaneous syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Costello+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Costello syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RASopathies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RASopathies</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Motta M</b>, Fasano G, Gredy S, Brinkmann J, Bonnard AA, Simsek-Kiper PO, Gulec EY, Essaddam L, Utine GE, Guarnetti Prandi I, Venditti M, Pantaleoni F, Radio FC, Ciolfi A, Petrini S, Consoli F, Vignal C, Hepbasli D, Ullrich M, de Boer E, Vissers LELM, Gritli S, Rossi C, De Luca A, Ben Becher S, Gelb BD, Dallapiccola B, Lauri A, Chillemi G, Schuh K, Cavé H, Zenker M, Tartaglia M. SPRED2 loss-of-function causes a recessive Noonan syndrome-like phenotype. <em class='incite-journal-name' onclick='ShowInCiteJournal(1743);'>Am J Hum Genet</em> 2021;<b>108</b>:2112-2129. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/34626534' target='_blank'>34626534</a> DOI: <a href='https://dx.doi.org/10.1016/j.ajhg.2021.09.007' target='_blank'>10.1016/j.ajhg.2021.09.007</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.ajhg.2021.09.007%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 29</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.ajhg.2021.09.007')">Impact Index Per Article: 9.7</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ajhg.2021.09.007','34626534', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ajhg.2021.09.007' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(1743);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/21/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/14/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/16/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.ajhg.2021.09.007" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Upregulated signal flow through RAS and the mitogen-associated protein kinase (MAPK) cascade is the unifying mechanistic theme of the RASopathies, a family of disorders affecting development and growth. Pathogenic variants in more than 20 genes have been causally linked to RASopathies, the majority having a dominant role in promoting enhanced signaling. Here, we report that SPRED2 loss of function is causally linked to a recessive phenotype evocative of Noonan syndrome. Homozygosity for three different variants-c.187C>T (p.Arg63<sup>∗</sup>), c.299T>C (p.Leu100Pro), and c.1142_1143delTT (p.Leu381Hisfs<sup>∗</sup>95)-were identified in four subjects from three families. All variants severely affected protein stability, causing accelerated degradation, and variably perturbed SPRED2 functional behavior. When overexpressed in cells, all variants were unable to negatively modulate EGF-promoted RAF1, MEK, and ERK phosphorylation, and time-course experiments in primary fibroblasts (p.Leu100Pro and p.Leu381Hisfs<sup>∗</sup>95) documented an increased and prolonged activation of the MAPK cascade in response to EGF stimulation. Morpholino-mediated knockdown of spred2a and spred2b in zebrafish induced defects in convergence and extension cell movements indicating upregulated RAS-MAPK signaling, which were rescued by expressing wild-type SPRED2 but not the SPRED2<sup>Leu381Hisfs</sup><sup>∗</sup><sup>95</sup> protein. The clinical phenotype of the four affected individuals included developmental delay, intellectual disability, cardiac defects, short stature, skeletal anomalies, and a typical facial gestalt as major features, without the occurrence of the distinctive skin signs characterizing Legius syndrome. These features, in part, characterize the phenotype of Spred2<sup>-/-</sup> mice. Our findings identify the second recessive form of Noonan syndrome and document pleiotropic consequences of SPRED2 loss of function in development.</div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAPK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAPK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RASopathies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RASopathies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SPRED%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SPRED</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SPRED1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SPRED1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SPRED2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SPRED2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromin</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alleles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alleles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COS+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COS Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chlorocebus+aethiops%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chlorocebus aethiops</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HEK293+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HEK293 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Loss+of+Function+Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Loss of Function Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+Syndrome%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan Syndrome/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Repressor+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Repressor Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zebrafish%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zebrafish</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NHLBI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R35 HL135742 NHLBI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Fowlkes JL</b>, Thrailkill KM, Bunn RC. RASopathies: The musculoskeletal consequences and their etiology and pathogenesis. <em class='incite-journal-name' onclick='ShowInCiteJournal(4121);'>Bone</em> 2021;<b>152</b>:116060. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/34144233' target='_blank'>34144233</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316423' target='_blank'>PMC8316423</a> DOI: <a href='https://dx.doi.org/10.1016/j.bone.2021.116060' target='_blank'>10.1016/j.bone.2021.116060</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.bone.2021.116060%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 13</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.bone.2021.116060')">Impact Index Per Article: 4.3</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bone.2021.116060','34144233', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(9);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bone.2021.116060' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4121);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/bone/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/03/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/07/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/10/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/07/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.bone.2021.116060" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The RASopathies comprise an ever-growing number of clinical syndromes resulting from germline mutations in components of the RAS/MAPK signaling pathway. While multiple organs and tissues may be affected by these mutations, this review will focus on how these mutations specifically impact the musculoskeletal system. Herein, we review the genetics and musculoskeletal phenotypes of these syndromes in humans. We discuss how mutations in the RASopathy syndromes have been studied in translational mouse models. Finally, we discuss how signaling molecules within the RAS/MAPK pathway are involved in normal and abnormal bone biology in the context of osteoblasts, osteoclasts and chondrocytes.</div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Capillary+malformation-arteriovenous+malformation+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Capillary malformation-arteriovenous malformation syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardio-facio-cutaneous+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardio-facio-cutaneous syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Costello+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Costello syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAS%2fMAPK+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAS/MAPK pathway</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+Syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan Syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ras+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ras Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ras+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ras Proteins/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDDK+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R56 DK084045 NIDDK NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Orlandi V</b>, Cavarzere P, Palma L, Gaudino R, Antoniazzi F. Central precocious puberty in a girl with <span class="highlight-field">LEGIUS syndrome</span>: an accidental association? <em class='incite-journal-name' onclick='ShowInCiteJournal(12782);'>Ital J Pediatr</em> 2021;<b>47</b>:50. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/33663580' target='_blank'>33663580</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934465' target='_blank'>PMC7934465</a> DOI: <a href='https://dx.doi.org/10.1186/s13052-021-01004-9' target='_blank'>10.1186/s13052-021-01004-9</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s13052-021-01004-9','33663580', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s13052-021-01004-9' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/9fe68dcd0176d927ad476099d4a46c58/PMC7934465.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12782);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/itjp/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/14/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/22/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/10/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1186/s13052-021-01004-9" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Central precocious puberty is a condition characterized by precocious activation of the hypothalamic-pituitary-gonadal axis. It may be idiopathic or secondary to organic causes, including syndromes such as Neurofibromatosis type 1 (NF1).</div><div class="abstract-label">CASE PRESENTATION</div><div class="abstract-content">We presented a girl of 6 years and 10 months with almost 11 café-au-lait skin macules, without other clinical or radiological signs typical of NF1, and with a central precocious puberty. Genetic analysis evidenced the new variant NM-152594.2:c.304delAp. (Thr102Argfs*19) in SPRED1 gene, which allowed to diagnose Legius syndrome.</div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">We report for the first time a case of central precocious puberty in a girl with Legius syndrome. The presence of central precocious puberty in a child with characteristic café-au-lait macules should suggest pediatricians to perform genetic analysis in order to reach a definitive diagnosis. Further studies on timing of puberty in patients with RASopathies are needed to better elucidate if this clinical association is casual or secondary to their clinical condition.</div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Precocious+puberty%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Precocious puberty</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rasophaties%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rasophaties</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Lorenzo C</b>, McCormick F. SPRED proteins and their roles in signal transduction, development, and malignancy. <em class='incite-journal-name' onclick='ShowInCiteJournal(9639);'>Genes Dev</em> 2020;<b>34</b>:1410-1421. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/33872193' target='_blank'>33872193</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608746' target='_blank'>PMC7608746</a> DOI: <a href='https://dx.doi.org/10.1101/gad.341222.120' target='_blank'>10.1101/gad.341222.120</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1101%2fgad.341222.120%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 25</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1101%2fgad.341222.120')">Impact Index Per Article: 6.3</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1101/gad.341222.120','33872193', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(11);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1101/gad.341222.120' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/9b70a92772e886f7ab2fe4b97c638357/PMC7608746.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1101/gad.341222.120');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9639);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/06/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1101/gad.341222.120" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The roles of SPRED proteins in signaling, development, and cancer are becoming increasingly recognized. SPRED proteins comprise an N-terminal EVH-1 domain, a central c-Kit-binding domain, and C-terminal SROUTY domain. They negatively regulate signaling from tyrosine kinases to the Ras-MAPK pathway. SPRED1 binds directly to both c-KIT and to the RasGAP, neurofibromin, whose function is completely dependent on this interaction. Loss-of-function mutations in SPRED1 occur in human cancers and cause the developmental disorder, Legius syndrome. Genetic ablation of SPRED genes in mice leads to behavioral problems, dwarfism, and multiple other phenotypes including increased risk of leukemia. In this review, we summarize and discuss biochemical, structural, and biological functions of these proteins including their roles in normal cell growth and differentiation and in human disease. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ras%e2%80%93MAPK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ras–MAPK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SPROUTY%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SPROUTY</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22signal+transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">signal transduction</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; 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Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. <em class='incite-journal-name' onclick='ShowInCiteJournal(5231);'>Cell Rep</em> 2020;<b>32</b>:107909. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/32697994' target='_blank'>32697994</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437355' target='_blank'>PMC7437355</a> DOI: <a href='https://dx.doi.org/10.1016/j.celrep.2020.107909' target='_blank'>10.1016/j.celrep.2020.107909</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.celrep.2020.107909%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 38</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.celrep.2020.107909')">Impact Index Per Article: 9.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.celrep.2020.107909','32697994', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(12);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.celrep.2020.107909' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/c223bc989d69f49125359c9093a1fcdc/PMC7437355.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1016/j.celrep.2020.107909');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5231);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/20/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/25/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/24/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/07/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.celrep.2020.107909" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Sprouty-related, EVH1 domain-containing (SPRED) proteins negatively regulate RAS/mitogen-activated protein kinase (MAPK) signaling following growth factor stimulation. This inhibition of RAS is thought to occur primarily through SPRED1 binding and recruitment of neurofibromin, a RasGAP, to the plasma membrane. Here, we report the structure of neurofibromin (GTPase-activating protein [GAP]-related domain) complexed with SPRED1 (EVH1 domain) and KRAS. The structure provides insight into how the membrane targeting of neurofibromin by SPRED1 allows simultaneous interaction with activated KRAS. SPRED1 and NF1 loss-of-function mutations occur across multiple cancer types and developmental diseases. Analysis of the neurofibromin-SPRED1 interface provides a rationale for mutations observed in Legius syndrome and suggests why SPRED1 can bind to neurofibromin but no other RasGAPs. We show that oncogenic EGFR(L858R) signaling leads to the phosphorylation of SPRED1 on serine 105, disrupting the SPRED1-neurofibromin complex. The structural, biochemical, and biological results provide new mechanistic insights about how SPRED1 interacts with neurofibromin and regulates active KRAS levels in normal and pathologic conditions. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAS-RAF-ERK+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAS-RAF-ERK pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RASopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RASopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RasGAP%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RasGAP</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis type 1</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amino+Acid+Sequence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amino Acid Sequence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-Lait+Spots%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Witkowski L</b>, Dillon MW, Murphy E, S Lebo M, Mason-Suares H. Expanding the Noonan spectrum/RASopathy NGS panel: Benefits of adding NF1 and SPRED1. <em class='incite-journal-name' onclick='ShowInCiteJournal(158177);'>Mol Genet Genomic Med</em> 2020;<b>8</b>:e1180. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/32107864' target='_blank'>32107864</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196473' target='_blank'>PMC7196473</a> DOI: <a href='https://dx.doi.org/10.1002/mgg3.1180' target='_blank'>10.1002/mgg3.1180</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1002%2fmgg3.1180%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 8</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1002%2fmgg3.1180')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/mgg3.1180','32107864', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/mgg3.1180' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/b24d3379ac0d22242e9d37a6da15e465/PMC7196473.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1002/mgg3.1180');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(158177);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/11/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/28/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/30/2020]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/13/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1002/mgg3.1180" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><p>RASopathies are a group of disorders caused by disruptions to the RAS‒MAPK pathway. Despite being in the same pathway, Neurofibromatosis Type 1 (NF1) and Legius syndrome (LS) typically present with phenotypes distinct from Noonan spectrum disorders (NSDs). However, some NF1/LS individuals also exhibit NSD phenotypes, often referred to as Neurofibromatosis‐Noonan syndrome (NFNS), and may be mistakenly evaluated for NSDs, delaying diagnosis, and affecting patient management.</p><div class="abstract-label">Methods</div><p>A derivation cohort of 28 patients with a prior negative NSD panel and either NFNS or a suspicion of NSD and café‐au‐lait spots underwent <italic>NF1</italic> and <italic>SPRED1</italic> sequencing. To further determine the utility and burden of adding these genes, a validation cohort of 505 patients with a suspected RASopathy were tested on a 14‐gene RASopathy‐associated panel.</p><div class="abstract-label">Results</div><p>In the derivation cohort, six (21%) patients had disease‐causing <italic>NF1</italic> or <italic>SPRED1</italic> variants. In the validation cohort, 11 (2%) patients had disease‐causing variants and 15 (3%) had variants of uncertain significance in <italic>NF1</italic> or <italic>SPRED1</italic>. Of those with disease‐causing variants, 5/17 only had an NSD diagnosis.</p><div class="abstract-label">Conclusions</div><p>Adding <italic>NF1</italic> and <italic>SPRED1</italic> to RASopathy panels can speed diagnosis and improve patient management, without significantly increasing the burden of inconclusive results.</p> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SPRED1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SPRED1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis-Noonan+syndrome+(NFNS)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis-Noonan syndrome (NFNS)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+syndrome+(NS)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan syndrome (NS)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+syndrome+with+multiple+lentigines+(NSML)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan syndrome with multiple lentigines (NSML)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RASopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RASopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Watson+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Watson syndrome</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Anderson S</b>. Café au Lait Macules and Associated Genetic Syndromes. <em class='incite-journal-name' onclick='ShowInCiteJournal(15175);'>J Pediatr Health Care</em> 2020;<b>34</b>:71-81. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/31831114' target='_blank'>31831114</a> DOI: <a href='https://dx.doi.org/10.1016/j.pedhc.2019.05.001' target='_blank'>10.1016/j.pedhc.2019.05.001</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.pedhc.2019.05.001%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 11</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.pedhc.2019.05.001')">Impact Index Per Article: 2.8</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.pedhc.2019.05.001','31831114', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.pedhc.2019.05.001' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(15175);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/ymph/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/05/2018]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/03/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/04/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/14/2022]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.pedhc.2019.05.001" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Café au lait macules (CALMs) are a common, isolated dermatologic finding in the general population. But when do these irregularly shaped, jagged-edged, flat, hyperpigmented birthmarks suggest something that may warrant referral? Most pediatric providers are familiar with the association of CALMs and neurofibromatosis type 1. There are, however, other genetic conditions associated with these seemingly benign skin spots. This article provides an overview of CALMs, followed by a summary of several conditions associated with CALMs ranging from the most common (neurofibromatosis type 1) to rare, ring chromosome syndromes. It reviews the associated gene(s), pattern of inheritance, incidence, presenting symptoms, diagnosis, and management for these genetic conditions.</div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Caf%c3%a9+au+lait+macule%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Café au lait macule</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22McCune-Albright+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">McCune-Albright syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+syndrome+with+multiple+lentigines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan syndrome with multiple lentigines</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis type 1</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-Lait+Spots%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cafe-au-Lait Spots/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibrous+Dysplasia%2c+Polyostotic%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibrous Dysplasia, Polyostotic/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Predisposition+to+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Predisposition to Disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplastic+Syndromes%2c+Hereditary%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplastic Syndromes, Hereditary/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+Syndrome%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan Syndrome/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ring+Chromosomes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ring Chromosomes</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Pacot L</b>, Burin des Roziers C, Laurendeau I, Briand-Suleau A, Coustier A, Mayard T, Tlemsani C, Faivre L, Thomas Q, Rodriguez D, Blesson S, Dollfus H, Muller YG, Parfait B, Vidaud M, Gilbert-Dussardier B, Yardin C, Dauriat B, Derancourt C, Vidaud D, Pasmant E. One <i>NF1</i> Mutation may Conceal Another. <em class='incite-journal-name' onclick='ShowInCiteJournal(9760);'>Genes (Basel)</em> 2019;<b>10</b>:genes10090633. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/31443423' target='_blank'>31443423</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769760' target='_blank'>PMC6769760</a> DOI: <a href='https://dx.doi.org/10.3390/genes10090633' target='_blank'>10.3390/genes10090633</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fgenes10090633%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 4</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fgenes10090633')">Impact Index Per Article: 0.8</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/genes10090633','31443423', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/genes10090633' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/483d9e55fa46b0df3fe43d282e27a653/PMC6769760.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/genes10090633');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9760);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/19/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/10/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/20/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/01/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.3390/genes10090633" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <p>Neurofibromatosis type 1 (NF1) is an autosomal dominant disease with complete penetrance but high variable expressivity. NF1 is caused by loss-of-function mutations in the <italic>NF1</italic> gene, a negative regulator of the RAS-MAPK pathway. The <italic>NF1</italic> gene has one of the highest mutation rates in human disorders, which may explain the outbreak of independent de novo variants in the same family. Here, we report the co-occurrence of pathogenic variants in the <italic>NF1</italic> and <italic>SPRED1</italic> genes in six families with NF1 and Legius syndrome, using next-generation sequencing. In five of these families, we observed the co-occurrence of two independent <italic>NF1</italic> variants. All <italic>NF1</italic> variants were classified as pathogenic, according to the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG-AMP) guidelines. In the sixth family, one sibling inherited a complete deletion of the <italic>NF1</italic> gene from her mother and carried a variant of unknown significance in the <italic>SPRED1</italic> gene. This variant was also present in her brother, who was diagnosed with Legius syndrome, a differential diagnosis of NF1. This work illustrates the complexity of molecular diagnosis in a not-so-rare genetic disease.</p> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SPRED1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SPRED1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22de+novo+variant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">de novo variant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis type 1</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-Lait+Spots%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cafe-au-Lait Spots/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-Lait+Spots%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cafe-au-Lait Spots/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-Lait+Spots%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cafe-au-Lait Spots/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pedigree%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pedigree</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Giugliano T</b>, Santoro C, Torella A, Del Vecchio Blanco F, Grandone A, Onore ME, Melone MAB, Straccia G, Melis D, Piccolo V, Limongelli G, Buono S, Perrotta S, Nigro V, Piluso G. Clinical and Genetic Findings in Children with Neurofibromatosis Type 1, <span class="highlight-field">Legius Syndrome</span>, and Other Related Neurocutaneous Disorders. <em class='incite-journal-name' onclick='ShowInCiteJournal(9760);'>Genes (Basel)</em> 2019;<b>10</b>:genes10080580. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/31370276' target='_blank'>31370276</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722641' target='_blank'>PMC6722641</a> DOI: <a href='https://dx.doi.org/10.3390/genes10080580' target='_blank'>10.3390/genes10080580</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fgenes10080580%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 20</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fgenes10080580')">Impact Index Per Article: 4.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/genes10080580','31370276', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/genes10080580' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/083e0671ddbfba03197ea8ea86979fba/PMC6722641.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9760);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/26/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/27/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/30/2019]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/07/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.3390/genes10080580" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <p>Pigmentary manifestations can represent an early clinical sign in children affected by Neurofibromatosis type 1 (NF1), Legius syndrome, and other neurocutaneous disorders. The differential molecular diagnosis of these pathologies is a challenge that can now be met by combining next generation sequencing of target genes with concurrent second-level tests, such as multiplex ligation-dependent probe amplification and RNA analysis. We clinically and genetically investigated 281 patients, almost all pediatric cases, presenting with either NF1 (<italic>n</italic> = 150), only pigmentary features (café au lait macules with or without freckling; (<italic>n</italic> = 95), or clinical suspicion of other RASopathies or neurocutaneous disorders (<italic>n</italic> = 36). The causative variant was identified in 239 out of the 281 patients analyzed (85.1%), while 42 patients remained undiagnosed (14.9%). The <italic>NF1</italic> and <italic>SPRED1</italic> genes were mutated in 73.3% and 2.8% of cases, respectively. The remaining 8.9% carried mutations in different genes associated with other disorders. We achieved a molecular diagnosis in 69.5% of cases with only pigmentary manifestations, allowing a more appropriate clinical management of these patients. Our findings, together with the increasing availability and sharing of clinical and genetic data, will help to identify further novel genotype–phenotype associations that may have a positive impact on patient follow-up.</p> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RASopathies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RASopathies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22multiplex+ligation-dependent+probe+amplification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">multiplex ligation-dependent probe amplification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22next+generation+sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">next generation sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-Lait+Spots%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cafe-au-Lait Spots/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-Lait+Spots%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cafe-au-Lait Spots/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Rauen KA</b>, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F. Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. <em class='incite-journal-name' onclick='ShowInCiteJournal(168570);'>Am J Med Genet A</em> 2018;<b>176</b>:2924-2929. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/30302932' target='_blank'>30302932</a> DOI: <a href='https://dx.doi.org/10.1002/ajmg.a.40632' target='_blank'>10.1002/ajmg.a.40632</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1002%2fajmg.a.40632%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 7</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1002%2fajmg.a.40632')">Impact Index Per Article: 1.2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/ajmg.a.40632','30302932', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(17);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/ajmg.a.40632' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168570);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/26/2018]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/02/2018]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/07/2022]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1002/ajmg.a.40632" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This report summarizes and highlights the fifth International RASopathies Symposium: When Development and Cancer Intersect, held in Orlando, Florida in July 2017. The RASopathies comprise a recognizable pattern of malformation syndromes that are caused by germ line mutations in genes that encode components of the RAS/mitogen-activated protein kinase (MAPK) pathway. Because of their common underlying pathogenetic etiology, there is significant overlap in their phenotypic features, which includes craniofacial dysmorphology, cardiac, cutaneous, musculoskeletal, gastrointestinal and ocular abnormalities, neurological and neurocognitive issues, and a predisposition to cancer. The RAS pathway is a well-known oncogenic pathway that is commonly found to be activated in somatic malignancies. As in somatic cancers, the RASopathies can be caused by various pathogenetic mechanisms that ultimately impact or alter the normal function and regulation of the MAPK pathway. As such, the RASopathies represent an excellent model of study to explore the intersection of the effects of dysregulation and its consequence in both development and oncogenesis.</div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Costello+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Costello syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAS%2fMAPK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAS/MAPK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RASopathies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RASopathies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cardio-facio-cutaneous+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cardio-facio-cutaneous syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22clinical+trial%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">clinical trial</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22signal+transduction+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">signal transduction pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">therapy</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Association+Studies%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Association Studies/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Predisposition+to+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Predisposition to Disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Human+Development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Human Development</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Models%2c+Biological%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Models, Biological</a></li><li><a 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NMR resonance assignments of the EVH1 domain of neurofibromin's recruitment factor Spred1. <em>BIOMOLECULAR NMR ASSIGNMENTS</em> 2017;<b>11</b>:305-308. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/28831766' target='_blank'>28831766</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594049' target='_blank'>PMC5594049</a> DOI: <a href='https://dx.doi.org/10.1007/s12104-017-9768-1' target='_blank'>10.1007/s12104-017-9768-1</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1007%2fs12104-017-9768-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 4</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1007%2fs12104-017-9768-1')">Impact Index Per Article: 0.6</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12104-017-9768-1','28831766', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(18);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s12104-017-9768-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1007/s12104-017-9768-1');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/11/2017]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/12/2017]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/07/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1007/s12104-017-9768-1" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromin and Sprouty-related EVH1 domain-containing protein 1 (Spred1) both act as negative regulators of the mitogen-activated protein kinase pathway and are associated with the rare diseases Neurofibromatosis type 1 and Legius syndrome, respectively. Spred1 recruits the major GTPase activating protein (GAP) neurofibromin from the cytosol to the membrane in order to inactivate the small G protein Ras. These functions are dependent on the N-terminal EVH1 domain and the C-terminal Sprouty domain of Spred1 whereas the former specifically recognizes the GAP related domain of neurofibromin and the latter is responsible for membrane targeting. Within the GAP domain, Spred1 binding depends on the GAPex portion which is dispensable for Ras inactivation. In a first step towards the characterization of the Neurofibromin Spred1 interface in solution we assigned backbone and side chain <sup>1</sup>H, <sup>13</sup>C, and <sup>15</sup>N chemical shifts of the Spred1 derived EVH1 domain. Our chemical shift data analysis indicate seven consecutive β-strands followed by a C-terminal α-helix which is in agreement with the previously reported crystal structure of Spred1(EVH1). Our data provide a framework for further analysis of the function of patient-derived mutations associated with rare diseases.</div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NMR+resonance+assignment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NMR resonance assignment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein purification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TALOS%2b+prediction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TALOS+ prediction</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adaptor+Proteins%2c+Signal+Transducing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adaptor Proteins, Signal Transducing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Proteins%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Proteins/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nuclear+Magnetic+Resonance%2c+Biomolecular%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nuclear Magnetic Resonance, Biomolecular</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Domains%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Domains</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%c3%96sterreichische+Krebs-Hilfe+(AT)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Österreichische Krebs-Hilfe (AT)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22University+of+Innsbruck+(AT)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">University of Innsbruck (AT)</a></li></ul> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Kimura R</b>, Yoshida Y, Maruoka R, Kosaki K, Yamamoto O. <span class="highlight-field">Legius syndrome</span>: A case report. <em class='incite-journal-name' onclick='ShowInCiteJournal(169828);'>J Dermatol</em> 2016;<b>44</b>:459-460. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/28378438' target='_blank'>28378438</a> DOI: <a href='https://dx.doi.org/10.1111/1346-8138.13687' target='_blank'>10.1111/1346-8138.13687</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1111%2f1346-8138.13687%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1111%2f1346-8138.13687')">Impact Index Per Article: 0.1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/1346-8138.13687','28378438', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/1346-8138.13687' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169828);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/19/2016]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/06/2016]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/30/2022]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1111/1346-8138.13687" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Legius syndrome is a rare genetic disorder caused by heterozygous germ line loss-of-function SPRED1 mutation. In Japan, a family with Legius syndrome was first described in 2015 by Sakai et al. We described a first solitary case of Legius syndrome identified by next-generation sequencing in Japan. A 37-year-old woman presented with multiple café-au-lait macules and freckles but has no other features of neurofibromatosis type 1 (NF-1). Sequencing results showed the presence of a mutation in exon 2 of SPRED1 c.70C>T, resulting in the protein at position 24 (p.Arg24X). When a dermatological clinician sees an adult patient showing only pigmented lesions and no other specifically diagnostic features of NF-1, it is important to suspect the possibility of Legius syndrome.</div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SPRED1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SPRED1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caf%c3%a9-au-lait+macules%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">café-au-lait macules</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22next-generation+sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">next-generation sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Hernández-Martín A</b>, Duat-Rodríguez A. An Update on Neurofibromatosis Type 1: Not Just Café-au-Lait Spots, Freckling, and Neurofibromas. An Update. Part I. Dermatological Clinical Criteria Diagnostic of the Disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(162682);'>ACTAS DERMO-SIFILIOGRAFICAS</em> 2016;<b>107</b>:454-64. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/26979265' target='_blank'>26979265</a> DOI: <a href='https://dx.doi.org/10.1016/j.ad.2016.01.004' target='_blank'>10.1016/j.ad.2016.01.004</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.ad.2016.01.004%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 16</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.ad.2016.01.004')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ad.2016.01.004','26979265', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ad.2016.01.004' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(162682);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/11/2015]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/07/2016]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/17/2016]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/10/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.ad.2016.01.004" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromatosis type 1 (NF1) is the most common neurocutaneous syndrome and probably the one best known to dermatologists, who are generally the first physicians to suspect its diagnosis. Although the genetic locus of NF1 was identified on chromosome 17 in 1987, diagnosis of the disease is still mainly based on clinical observations and the diagnostic criteria of the National Institute of Health, dating from 1988. Cutaneous manifestations are particularly important because café-au-lait spots, freckling on flexural areas, and cutaneous neurofibromas comprise 3 of the 7 clinical diagnostic criteria. However, café-au-lait spots and freckling can also be present in other diseases. These manifestations are therefore not pathognomonic and are insufficient for definitive diagnosis in the early years of life. NF1 is a multisystemic disease associated with a predisposition to cancer. A multidisciplinary follow-up is necessary and dermatologists play an important role. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Albinism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Albinism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-lait+spots%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cafe-au-lait spots</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ef%c3%a9lides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Efélides</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ephelids%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ephelids</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Freckling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Freckling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LEOPARD+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LEOPARD syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mancha+caf%c3%a9+con+leche%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mancha café con leche</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibroma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibroma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+tipo+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis tipo 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromina%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromina</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pecas%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pecas</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Piebaldismo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Piebaldismo</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RASopathies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RASopathies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rasopat%c3%adas%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rasopatías</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22S%c3%adndrome+LEOPARD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Síndrome LEOPARD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22S%c3%adndrome+de+Legius%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Síndrome de Legius</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-Lait+Spots%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cafe-au-Lait Spots/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibroma%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibroma/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Skin+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Skin Neoplasms/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Rojnueangnit K</b>, Xie J, Gomes A, Sharp A, Callens T, Chen Y, Liu Y, Cochran M, Abbott M, Atkin J, Babovic‐Vuksanovic D, Barnett CP, Crenshaw M, Bartholomew DW, Basel L, Bellus G, Ben‐Shachar S, Bialer MG, Bick D, Blumberg B, Cortes F, David KL, Destree A, Duat‐Rodriguez A, Earl D, Escobar L, Eswara M, Ezquieta B, Frayling IM, Frydman M, Gardner K, Gripp KW, Hernández‐Chico C, Heyrman K, Ibrahim J, Janssens S, Keena BA, Llano‐Rivas I, Leppig K, McDonald M, Misra VK, Mulbury J, Narayanan V, Orenstein N, Galvin‐Parton P, Pedro H, Pivnick EK, Powell CM, Randolph L, Raskin S, Rosell J, Rubin K, Seashore M, Schaaf CP, Scheuerle A, Schultz M, Schorry E, Schnur R, Siqveland E, Tkachuk A, Tonsgard J, Upadhyaya M, Verma IC, Wallace S, Williams C, Zackai E, Zonana J, Lazaro C, Claes K, Korf B, Martin Y, Legius E, Messiaen L. High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype-Phenotype Correlation. <em class='incite-journal-name' onclick='ShowInCiteJournal(10577);'>Hum Mutat</em> 2015;<b>36</b>:1052-63. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/26178382' target='_blank'>26178382</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049609' target='_blank'>PMC5049609</a> DOI: <a href='https://dx.doi.org/10.1002/humu.22832' target='_blank'>10.1002/humu.22832</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1002%2fhumu.22832%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 134</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1002%2fhumu.22832')">Impact Index Per Article: 14.9</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/humu.22832','26178382', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/humu.22832' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/48a9df3c1f7cd6663ed2834738a47b22/PMC5049609.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10577);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/20/2015]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/19/2015]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/15/2022]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1002/humu.22832" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromatosis type 1 (NF1) is one of the most frequent genetic disorders, affecting 1:3,000 worldwide. Identification of genotype-phenotype correlations is challenging because of the wide range clinical variability, the progressive nature of the disorder, and extreme diversity of the mutational spectrum. We report 136 individuals with a distinct phenotype carrying one of five different NF1 missense mutations affecting p.Arg1809. Patients presented with multiple café-au-lait macules (CALM) with or without freckling and Lisch nodules, but no externally visible plexiform neurofibromas or clear cutaneous neurofibromas were found. About 25% of the individuals had Noonan-like features. Pulmonic stenosis and short stature were significantly more prevalent compared with classic cohorts (P < 0.0001). Developmental delays and/or learning disabilities were reported in over 50% of patients. Melanocytes cultured from a CALM in a segmental NF1-patient showed two different somatic NF1 mutations, p.Arg1809Cys and a multi-exon deletion, providing genetic evidence that p.Arg1809Cys is a loss-of-function mutation in the melanocytes and causes a pigmentary phenotype. Constitutional missense mutations at p.Arg1809 affect 1.23% of unrelated NF1 probands in the UAB cohort, therefore this specific NF1 genotype-phenotype correlation will affect counseling and management of a significant number of patients. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22p.Arg1809%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">p.Arg1809</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22phenotype-genotype+correlations%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">phenotype-genotype correlations</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amino+Acid+Substitution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amino Acid Substitution</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Codon%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Codon</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cohort+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cohort Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dwarfism%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dwarfism/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Association+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Association Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%2c+Missense%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation, Missense</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+Syndrome%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan Syndrome/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+Syndrome%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan Syndrome/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Rauen KA</b>, Huson SM, Burkitt-Wright E, Evans DG, Farschtschi S, Ferner RE, Gutmann DH, Hanemann CO, Kerr B, Legius E, Parada LF, Patton M, Peltonen J, Ratner N, Riccardi VM, van der Vaart T, Vikkula M, Viskochil DH, Zenker M, Upadhyaya M. Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues. <em class='incite-journal-name' onclick='ShowInCiteJournal(168570);'>Am J Med Genet A</em> 2015;<b>167A</b>:1-10. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/25393061' target='_blank'>25393061</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275383' target='_blank'>PMC4275383</a> DOI: <a href='https://dx.doi.org/10.1002/ajmg.a.36793' target='_blank'>10.1002/ajmg.a.36793</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1002%2fajmg.a.36793%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 34</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1002%2fajmg.a.36793')">Impact Index Per Article: 3.8</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/ajmg.a.36793','25393061', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(22);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/ajmg.a.36793' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168570);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/09/2022]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1002/ajmg.a.36793" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromatosis type 1 (NF1) was the first RASopathy and is now one of many RASopathies that are caused by germline mutations in genes that encode components of the Ras/mitogen-activated protein kinase (MAPK) pathway. Their common underlying pathogenetic etiology causes significant overlap in phenotypic features which includes craniofacial dysmorphology, cardiac, cutaneous, musculoskeletal, GI and ocular abnormalities, and a predisposition to cancer. The proceedings from the symposium "Recent Developments in Neurofibromatoses (NF) and RASopathies: Management, Diagnosis and Current and Future Therapeutic Avenues" chronicle this timely and topical clinical translational research symposium. The overarching goal was to bring together clinicians, basic scientists, physician-scientists, advocate leaders, trainees, students and individuals with Ras pathway syndromes to discuss the most state-of-the-art basic science and clinical issues in an effort to spark collaborations directed towards the best practices and therapies for individuals with RASopathies. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Costello+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Costello syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Noonan+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Noonan syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RASopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RASopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ras%2fMAPK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ras/MAPK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22capillary+malformation-AV+malformation+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">capillary malformation-AV malformation syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cardio-facio-cutaneous+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cardio-facio-cutaneous syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22signal+transduction+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">signal transduction pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">therapy</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clinical+Trials+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clinical Trials as Topic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatoses%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatoses/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatoses%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatoses/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Burden%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Burden</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ras+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ras Proteins/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wellcome+Trust%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wellcome Trust</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 AR062165 NIAMS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AR062165 NIAMS NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Marque M</b>, Roubertie A, Jaussent A, Carneiro M, Meunier L, Guillot B, Pinson L, Pinson S, Bessis D. Nevus anemicus in neurofibromatosis type 1: a potential new diagnostic criterion. <em class='incite-journal-name' onclick='ShowInCiteJournal(15578);'>J Am Acad Dermatol</em> 2013;<b>69</b>:768-775. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/23972508' target='_blank'>23972508</a> DOI: <a href='https://dx.doi.org/10.1016/j.jaad.2013.06.039' target='_blank'>10.1016/j.jaad.2013.06.039</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.jaad.2013.06.039%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 39</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.jaad.2013.06.039')">Impact Index Per Article: 3.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jaad.2013.06.039','23972508', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jaad.2013.06.039' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(15578);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/08/2013]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/09/2013]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/21/2013]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/31/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.jaad.2013.06.039" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Children with multiple café-au-lait macules (CALMs) may be followed for years before a second National Institutes of Health clinical criterion of neurofibromatosis type 1 (NF1) develops to confirm the diagnosis.</div><div class="abstract-label">OBJECTIVE</div><div class="abstract-content">We sought to assess the prevalence of nevus anemicus (NA) in NF1 and its association with neuro-ophthalmologic complications.</div><div class="abstract-label">METHODS</div><div class="abstract-content">This was a prospective multicenter case-control study of 210 consecutive patients with multiple CALMs. Patients with NF1 were matched for age, sex, and center with control subjects. We documented the number, location, and morphologic appearance of NA; dermatologic features of NF1; magnetic resonance imaging results; and family history.</div><div class="abstract-label">RESULTS</div><div class="abstract-content">In all, 77 (51%) patients with NF1 had NA compared with 6 (2%) control subjects. NA was not detected in 26 patients with other genodermatoses associated with CALMs. Patients with NF1 and NA were younger than those without NA (median age: 17 years) (P = .002). NA was mostly localized to the upper anterior aspect of the chest. NA was not significantly linked with other clinical manifestations of NF1, including optic glioma and unidentified bright objects.</div><div class="abstract-label">LIMITATIONS</div><div class="abstract-content">A potential referral bias associated with tertiary care centers is a limitation.</div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">NA appears to have a high prevalence and specificity in NF1 and might serve as a marker for NF1 in children with multiple CALMs.</div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CALM%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CALM</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22JXG%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">JXG</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NIH</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Institutes+of+Health%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Institutes of Health</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22OG%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">OG</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PN%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PN</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22UBO%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">UBO</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caf%c3%a9-au-lait+macule%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">café-au-lait macule</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22caf%c3%a9-au-lait+macules%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">café-au-lait macules</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22juvenile+xanthogranuloma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">juvenile xanthogranuloma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nevus+anemicus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nevus anemicus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22optic+glioma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">optic glioma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22plexiform+neurofibroma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">plexiform neurofibroma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22unidentified+bright+object%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">unidentified bright object</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> The SPRED1 Variants Repository for <span class="highlight-field">Legius Syndrome</span>. <em>G3-GENES GENOMES GENETICS</em> 2011;<b>1</b>:451-6. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/22384355' target='_blank'>22384355</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276167' target='_blank'>PMC3276167</a> DOI: <a href='https://dx.doi.org/10.1534/g3.111.000687' target='_blank'>10.1534/g3.111.000687</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1534%2fg3.111.000687%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 11</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1534%2fg3.111.000687')">Impact Index Per Article: 0.8</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1534/g3.111.000687','22384355', 'Legius syndrome')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1534/g3.111.000687' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/74081dd7dd551ba1efe195d9948fcaa9/PMC3276167.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1534/g3.111.000687');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/07/2011]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/16/2011]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/23/2022]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1534/g3.111.000687" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <p>Legius syndrome (LS) is an autosomal dominant disorder caused by germline loss-of-function mutations in the sprouty-related, EVH1 domain containing 1 (<italic>SPRED1</italic>) gene. The phenotype of LS is multiple café au lait macules (CALM) with other commonly reported manifestations, including intertriginous freckling, lipomas, macrocephaly, and learning disabilities including ADHD and developmental delays. Since the earliest signs of LS and neurofibromatosis type 1 (NF1) syndrome are pigmentary findings, the two are indistinguishable and individuals with LS may meet the National Institutes of Health diagnostic criteria for NF1 syndrome. However, individuals are not known to have an increased risk for developing tumors (compared with NF1 patients). It is therefore important to fully characterize the phenotype differences between NF1 and LS because the prognoses of these two disorders differ greatly. We have developed a mutation database that characterizes the known variants in the <italic>SPRED1</italic> gene in an effort to facilitate this process for testing and interpreting results. This database is free to the public and will be updated quarterly.</p> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Legius+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Legius syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SPRED1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SPRED1</a></li><li><a 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class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Legius syndrome (24 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="24" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Legius syndrome (24 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="24" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>