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Available in 14 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-14" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">14 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%85%D9%8A%D8%AA%D8%A7%D8%B3%D9%8A%D9%83" title="ميتاسيك – Arabic" lang="ar" hreflang="ar" data-title="ميتاسيك" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/MetaCyc" title="MetaCyc – Bosnian" lang="bs" hreflang="bs" data-title="MetaCyc" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/MetaCyc" title="MetaCyc – Catalan" lang="ca" hreflang="ca" data-title="MetaCyc" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/MetaCyc" title="MetaCyc – Spanish" lang="es" hreflang="es" data-title="MetaCyc" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%85%D8%AA%D8%A7%D8%B3%D8%A7%DB%8C%DA%A9" title="متاسایک – Persian" lang="fa" hreflang="fa" data-title="متاسایک" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/MetaCyc" title="MetaCyc – French" lang="fr" hreflang="fr" data-title="MetaCyc" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/MetaCyc" title="MetaCyc – Galician" lang="gl" hreflang="gl" data-title="MetaCyc" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/MetaCyc" title="MetaCyc – Korean" lang="ko" hreflang="ko" data-title="MetaCyc" 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searchaux" style="display:none">Metabolic pathways and enzymes database</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox vevent" style="width:"><caption class="infobox-title summary">MetaCyc</caption><tbody><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File"><a href="/wiki/File:Database.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/3/38/Database.png" decoding="async" width="16" height="16" class="mw-file-element" data-file-width="16" data-file-height="16" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: lavender">Content</th></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Description</th><td class="infobox-data">Database of <a href="/wiki/Metabolic_pathway" title="Metabolic pathway">metabolic pathways</a> and enzymes</td></tr><tr><th colspan="2" class="infobox-header" style="background-color: lavender">Contact</th></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap"><a href="/wiki/Research_center" class="mw-redirect" title="Research center">Research center</a></th><td class="infobox-data"><a href="/wiki/SRI_International" title="SRI International">SRI International</a></td></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Authors</th><td class="infobox-data">R. Caspi, H. Foerster, C.A. Fulcher, L.A. Mueller, <a href="/wiki/Peter_Karp_(scientist)" title="Peter Karp (scientist)">Peter Karp</a></td></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Primary citation</th><td class="infobox-data">Caspi et al. (2014)<sup id="cite_ref-pmid24225315_1-0" class="reference"><a href="#cite_note-pmid24225315-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Release date</th><td class="infobox-data">1997</td></tr><tr><th colspan="2" class="infobox-header" style="background-color: lavender">Access</th></tr><tr><th scope="row" class="infobox-label" style="white-space: nowrap">Website</th><td class="infobox-data"><span class="url"><a rel="nofollow" class="external text" href="http://metacyc.org">metacyc<wbr />.org</a></span></td></tr></tbody></table> <p>The <b>MetaCyc</b> database is one of the largest <a href="/wiki/Metabolic_pathways" class="mw-redirect" title="Metabolic pathways">metabolic pathways</a> and <a href="/wiki/Enzymes" class="mw-redirect" title="Enzymes">enzymes</a> databases currently available. The data in the database is manually curated from the scientific literature, and covers all domains of life. MetaCyc has extensive information about chemical compounds, reactions, metabolic pathways and enzymes. The data have been curated from more than 58,000 publications.<sup id="cite_ref-pmid24225315_1-1" class="reference"><a href="#cite_note-pmid24225315-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-metacyc.org_2-0" class="reference"><a href="#cite_note-metacyc.org-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid21523460_3-0" class="reference"><a href="#cite_note-pmid21523460-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>MetaCyc has been designed for multiple types of uses. It is often used as an extensive online encyclopedia of metabolism. In addition, MetaCyc is used as a reference data set for computationally predicting the metabolic network of organisms from their sequenced genomes; it has been used to perform pathway predictions for thousands of organisms, including those in the <a href="/wiki/BioCyc_Database_Collection" class="mw-redirect" title="BioCyc Database Collection">BioCyc Database Collection</a>. MetaCyc is also used in <a href="/wiki/Metabolic_engineering" title="Metabolic engineering">metabolic engineering</a> and <a href="/wiki/Metabolomics" title="Metabolomics">metabolomics</a> research. </p><p>MetaCyc includes mini reviews for pathways and enzymes that provide background information as well as relevant literature references. It also provides extensive data on individual enzymes, describing their subunit structure, cofactors, activators and inhibitors, substrate specificity, and, when available, kinetic constants. MetaCyc data on <a href="/wiki/Metabolites" class="mw-redirect" title="Metabolites">metabolites</a> includes chemical structures, predicted Standard energy of formation, and links to external databases. Reactions in MetaCyc are presented in a visual display that includes the structures of all components. The reactions are balanced and include <a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC numbers</a>, reaction direction, predicted atom mappings that describe the correspondence between atoms in the reactant compounds and the product compounds, and computed <a href="/wiki/Gibbs_free_energy" title="Gibbs free energy">Gibbs free energy</a>. </p><p>All objects in MetaCyc are clickable and provide easy access to related objects. For example, the page for L-lysine lists all of the reactions in which L-lysine participates, as well as the enzymes that catalyze them and pathways in which these reactions take place. </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=MetaCyc&action=edit&section=1" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns 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.citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nucleic+Acids+Res.&rft.atitle=The+MetaCyc+database+of+metabolic+pathways+and+enzymes+and+the+BioCyc+collection+of+Pathway%2FGenome+Databases&rft.volume=38&rft.issue=Database+issue&rft.pages=D473-9&rft.date=2014-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2808959%23id-name%3DPMC&rft_id=info%3Apmid%2F19850718&rft_id=info%3Adoi%2F10.1093%2Fnar%2Fgkp875&rft.aulast=Caspi&rft.aufirst=R&rft.au=Altman%2C+T&rft.au=Billington%2C+R&rft.au=Dreher%2C+K&rft.au=Foerster%2C+H&rft.au=Fulcher%2C+CA&rft.au=Holland%2C+TA&rft.au=Keseler%2C+IM&rft.au=Kothari%2C+A&rft.au=Kubo%2C+A&rft.au=Krummenacker%2C+M&rft.au=Latendresse%2C+M&rft.au=Mueller%2C+LA&rft.au=Ong%2C+Q&rft.au=Paley%2C+S&rft.au=Subhraveti%2C+P&rft.au=Weaver%2C+DS&rft.au=Weerasinghe%2C+D&rft.au=Zhang%2C+P&rft.au=Karp%2C+PD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2808959&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMetaCyc" 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