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window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":4433534,"created_at":"2013-09-08T01:19:34.000-07:00","from_world_paper_id":119455699,"updated_at":"2024-11-15T11:48:55.286-08:00","_data":{"grobid_abstract":"The biological tissues exhibit their distinct optical characteristics. Their point-to-point compositional variation could either be determined by the optical parameters or reconstruction of the reflectance or tomographic images. The optical parameters, absorption and reduced scattering coefficients of goat tissues and human post-mastectomy breast specimen are determined by matching of their reflectance profile, as measured by multi-probe laser reflectometer, with that obtained by Monte Carlo simulation of optical scattering. The reflectance image of the mastectomy sample is reconstructed by measurement of reflectance at its various locations. The image thus obtained shows point-to-point variation in tissue composition. By multi-slice tomographic system the size and shape of the inclusions of different optical properties in a phantom made of goat fat are determined. By these procedures the structural variation in healthy and diseased tissues are determined and their relevance to early detection of tumour in tissues is discussed.","grobid_abstract_attachment_id":"49865519"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Optical characterization and imaging of biological tissues","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [5449851]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container 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data-entity-id="17016800" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17016800/Characterization_of_Spatial_and_Temporal_Variations_in_the_Optical_Properties_of_Tissuelike_Media_with_Diffuse_Reflectance_Imaging">Characterization of Spatial and Temporal Variations in the Optical Properties of Tissuelike Media with Diffuse Reflectance Imaging</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="19629087" href="https://sdstate.academia.edu/ArmelKaptue">Armel Kaptue</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Applied Optics, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Characterization of Spatial and Temporal Variations in the Optical Properties of 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class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/9081433/Optical_properties_of_biological_tissues_a_review"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="66067250" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/66067250/Image_reconstruction_of_optical_attenuation_coefficient_variation_in_biological_tissues">Image reconstruction of optical attenuation coefficient variation in biological tissues</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="100793817" href="https://independent.academia.edu/ChackoSusamma">Susamma Chacko</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2003</p><p class="ds-related-work--abstract ds2-5-body-sm">A procedure for non-invasive imaging of the optical attenuation coefficient variation of in vivo thick organs/tissues is developed. The laser back-scattered surface profiles at various locations of human forearm, by multi-probe reflectometer, are measured. These profiles are matched by iterative procedure, with that as obtained by Monte Carlo simulation and the corresponding values of attenuation coefficient (equal to the sum of absorption and reduced scattering coefficients) are determined. By interpolation of this data a 100 x 100 grid is constructed and after median filtering of this data a color-coded image of the variability of the optical attenuation coefficient of the forearm is obtained. These images in different subjects show variation due to change in overall tissue composition and blood pooling. This non-invasive imaging procedure may help in identifying the diseased affected regions in healthy tissues and in application of photodynamic therapy.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Image reconstruction of optical attenuation coefficient variation in biological tissues","attachmentId":77404643,"attachmentType":"pdf","work_url":"https://www.academia.edu/66067250/Image_reconstruction_of_optical_attenuation_coefficient_variation_in_biological_tissues","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/66067250/Image_reconstruction_of_optical_attenuation_coefficient_variation_in_biological_tissues"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="84839848" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/84839848/Reflectance_based_determination_of_optical_properties_in_highly_attenuating_tissue">Reflectance-based determination of optical properties in highly attenuating tissue</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8879721" href="https://uci.academia.edu/AnthonyDurkin">Anthony J. Durkin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biomedical Optics, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reflectance-based determination of optical properties in highly attenuating tissue","attachmentId":89727638,"attachmentType":"pdf","work_url":"https://www.academia.edu/84839848/Reflectance_based_determination_of_optical_properties_in_highly_attenuating_tissue","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/84839848/Reflectance_based_determination_of_optical_properties_in_highly_attenuating_tissue"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="2885214" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2885214/Local_optical_characterization_of_biological_tissues_in_vitro_and_in_vivo">Local optical characterization of biological tissues in vitro and in vivo</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2974599" href="https://ircam.academia.edu/FredericBevilacqua">Frederic Bevilacqua</a></div><p class="ds-related-work--metadata ds2-5-body-xs">1998</p><p class="ds-related-work--abstract ds2-5-body-sm">Abstract Two methods for measuring the optical properties of tissue, ie reduced scattering and absorption coefficient, were developed. The first one was designed for in vitro investigations. It is based on the measurement of the spatially resolved transmittance through a tissue slab (typically 5mm thick). The second one was designed for local in vivo investigations. It is based on the measurement of the spatially-resolved diffuse reflectance, close to the source (< 2mm).</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Local optical characterization of biological tissues in vitro and in vivo","attachmentId":30818338,"attachmentType":"pdf","work_url":"https://www.academia.edu/2885214/Local_optical_characterization_of_biological_tissues_in_vitro_and_in_vivo","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2885214/Local_optical_characterization_of_biological_tissues_in_vitro_and_in_vivo"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="28482074" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/28482074/Tissue_characterization_by_quantitative_optical_imaging_methods">Tissue characterization by quantitative optical imaging methods</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="53411204" href="https://independent.academia.edu/VictorChernomordik">Victor Chernomordik</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Technology in cancer research & treatment, 2003</p><p class="ds-related-work--abstract ds2-5-body-sm">Optical methods have a long history in the field of medical diagnosis. The biomolecular specificity possible with optical methods has been particularly valuable in microscopy and histopathology while in vivo imaging of deep structures has traditionally been the domain of X-ray and MRI. The use of optical methods in deep tissue has been limited by multiple-scattering which blurs or distorts the optical signal. New stochastic methods which account for multiple scattering have been developed that are extending the usefulness of optical methods deep into tissue. In optical mammography, photons may travel through 10 cm of tissue before arriving at the detector. We have developed a method for quantifying parameters of anomalous sites in breast tissue that may be used for functional characterization of tumors. In other work presented here, we are developing fluorescence based methods to detect and monitor tumor status. The immune response to a tumor is a target for fluorescently labeled sp...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue characterization by quantitative optical imaging methods","attachmentId":48830627,"attachmentType":"pdf","work_url":"https://www.academia.edu/28482074/Tissue_characterization_by_quantitative_optical_imaging_methods","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/28482074/Tissue_characterization_by_quantitative_optical_imaging_methods"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="5967721" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/5967721/Spatially_resolved_absolute_diffuse_reflectance_measurements_for_noninvasive_determination_of_the_optical_scattering_and_absorption_coefficients_of_biological_tissue">Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8897297" href="https://uni-ulm.academia.edu/RudolfSteiner">Rudolf Steiner</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Applied Optics, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue","attachmentId":49072933,"attachmentType":"pdf","work_url":"https://www.academia.edu/5967721/Spatially_resolved_absolute_diffuse_reflectance_measurements_for_noninvasive_determination_of_the_optical_scattering_and_absorption_coefficients_of_biological_tissue","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/5967721/Spatially_resolved_absolute_diffuse_reflectance_measurements_for_noninvasive_determination_of_the_optical_scattering_and_absorption_coefficients_of_biological_tissue"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":49865519,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":49865519,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_49865519" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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