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data-dom-id="ProfileCheckPaperUpdate-react-component-cb762fcc-298d-4f39-8b3b-a1e90b227449"></div> <div id="ProfileCheckPaperUpdate-react-component-cb762fcc-298d-4f39-8b3b-a1e90b227449"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Nam Wang</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://umcp.academia.edu/">University of Maryland, College Park</a>, <a class="u-tcGrayDarker" 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translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">35</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">12</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">5</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a 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class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Nam Wang</h3></div><div class="js-work-strip profile--work_container" data-work-id="125721358"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/125721358/Hydrolysis_of_wheat_starch_and_its_effect_on_the_Falling_Number_procedure_experimental_observations"><img alt="Research paper thumbnail of Hydrolysis of wheat starch and its effect on the Falling Number procedure: experimental observations" class="work-thumbnail" src="https://attachments.academia-assets.com/119712856/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125721358/Hydrolysis_of_wheat_starch_and_its_effect_on_the_Falling_Number_procedure_experimental_observations">Hydrolysis of wheat starch and its effect on the Falling Number procedure: experimental observations</a></div><div class="wp-workCard_item"><span>Journal of the Science of Food and Agriculture</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="23f9485307a68173e60b0e2c28a18d12" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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href="https://www.academia.edu/125721357/Monitoring_Polymerization_Reactions_by_Near_IR_Spectroscopy"><img alt="Research paper thumbnail of Monitoring Polymerization Reactions by Near-IR Spectroscopy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125721357/Monitoring_Polymerization_Reactions_by_Near_IR_Spectroscopy">Monitoring Polymerization Reactions by Near-IR Spectroscopy</a></div><div class="wp-workCard_item"><span>Acs Symposium Series</span><span>, May 5, 1995</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span 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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125721356/Spoilage_of_Milk_and_Dairy_Products">Spoilage of Milk and Dairy Products</a></div><div class="wp-workCard_item"><span>Elsevier eBooks</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Milk’s combination of water, fats, proteins, and vitamins allows for the growth of a variety of b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Milk’s combination of water, fats, proteins, and vitamins allows for the growth of a variety of bacteria, especially psychrotrophic bacteria that are able to 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120904433"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120904433/Extended_delivery_of_non_steroidal_anti_inflammatory_drugs_through_contact_lenses_loaded_with_Vitamin_E_and_cationic_surfactants"><img alt="Research paper thumbnail of Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants" class="work-thumbnail" src="https://attachments.academia-assets.com/115910870/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120904433/Extended_delivery_of_non_steroidal_anti_inflammatory_drugs_through_contact_lenses_loaded_with_Vitamin_E_and_cationic_surfactants">Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants</a></div><div class="wp-workCard_item"><span>Contact Lens and Anterior Eye</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="66d63cdd47066ac374ad399e61422e79" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115910870,"asset_id":120904433,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115910870/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120904433"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120904433"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120904433; 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Fortunately, momentum requirements are relaxed in the 1-5 nm diameter Si crystals as a result of quantum confinement effects, and bright photoluminescence (PL) in the UV-vis range is achieved. Photoluminescent Si nanocrystals along with the C-and SiC-based nanoparticles are considered bioinert and may lead to the development of biocompatible and smaller probes than the well-known metal chalcogenide-based quantum dots. Published Si nanocrystal production procedures typically do not allow for the fine control of the particle size. An accepted way to make the H-terminated Si nanocrystals consists of anodic Si wafer etching with the subsequent breakup of the porous film in an ultrasound bath. Resulting H-termination provides a useful platform for further chemical derivatization and conjugation to biomolecules. However, a rather polydisperse mixture is produced following the ultrasonic treatment, leading to the distributed band gap energies and the extent of surface passivation. From the technological point of view, a homogeneous nanoparticle size mixture is highly desirable. In this study, we offer an efficient way to reduce the H-terminated Si nanocrystal diameter and narrow size distribution through photocatalyzed dissolution in a HF/HNO 3 acid mixture. Si particles were produced using the lateral etching of a Si wafer in a HF/EtOH/H 2 O bath followed by sonication in deaerated methanol. Initial suspensions exhibited broad photoluminescence in the red spectral region. Photoassisted etching was carried out by adding the HF/HNO 3 acid mixture to the suspension and exposing it to a 340 nm light. Photoluminescence and absorbance spectra, measured during dissolution, show the gradual particle size decrease as confirmed by the photoluminescence blue shift. The simultaneous narrowing of the photoluminescence spectral bandwidth suggests that the dissolution rate varies with the particle size. We show that the Si nanoparticle dissolution rate depends on the amount of light adsorbed by the particle and accounts for the etching rate variation with the particle size. Significant improvement in the PL quantum yield is observed during the acid treatment, suggesting improvement in the dangling bond passivation.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"ECS Meeting Abstracts","grobid_abstract_attachment_id":115910825},"translated_abstract":null,"internal_url":"https://www.academia.edu/120904382/Photo_Assisted_Tuning_of_Si_Nano_Crystal_Photoluminescence","translated_internal_url":"","created_at":"2024-06-12T01:15:55.117-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38560448,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115910825,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115910825/thumbnails/1.jpg","file_name":"ChoiJonghoon_Photoassisted_Tuning_of_Silicon_Nanocrystal_Photoluminescence.pdf","download_url":"https://www.academia.edu/attachments/115910825/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Photo_Assisted_Tuning_of_Si_Nano_Crystal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115910825/ChoiJonghoon_Photoassisted_Tuning_of_Silicon_Nanocrystal_Photoluminescence-libre.pdf?1718181097=\u0026response-content-disposition=attachment%3B+filename%3DPhoto_Assisted_Tuning_of_Si_Nano_Crystal.pdf\u0026Expires=1732780219\u0026Signature=ZTjNaCL4Lj91CPzrKbNSjs19Fj6ZL0O8sKROidQMr0wzq3D2mZwz81i5NCZ1-cOQbL5uUPpwOs3B4j0XIPtDb9AGWwpAkMvIyro-~Be~XC5VMq1dN0~JhZf7oqFWZy2SYRpkGuXDpqw2EUXzUX3BtAr~Ml3Kt30bennZI6NBRNIK921i~UHq-EJEQllrayi7jEKMohLZmBd3y5-4jYuMoCT1qulO83rivFdr6DiSUfP-QSRZ0R--NXIviQfIbMWUDJdtUu1PCPa0cLtK9xpNrjcthHEXhYOGK3oEpe-tlHF5V5hxKkMjusgKuTY5Ww6FJtnYPMf0ijUZgYVD3-5vmQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Photo_Assisted_Tuning_of_Si_Nano_Crystal_Photoluminescence","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":38560448,"first_name":"Nam","middle_initials":null,"last_name":"Wang","page_name":"NamWang","domain_name":"umcp","created_at":"2015-11-17T12:28:19.888-08:00","display_name":"Nam Wang","url":"https://umcp.academia.edu/NamWang"},"attachments":[{"id":115910825,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115910825/thumbnails/1.jpg","file_name":"ChoiJonghoon_Photoassisted_Tuning_of_Silicon_Nanocrystal_Photoluminescence.pdf","download_url":"https://www.academia.edu/attachments/115910825/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Photo_Assisted_Tuning_of_Si_Nano_Crystal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115910825/ChoiJonghoon_Photoassisted_Tuning_of_Silicon_Nanocrystal_Photoluminescence-libre.pdf?1718181097=\u0026response-content-disposition=attachment%3B+filename%3DPhoto_Assisted_Tuning_of_Si_Nano_Crystal.pdf\u0026Expires=1732780219\u0026Signature=ZTjNaCL4Lj91CPzrKbNSjs19Fj6ZL0O8sKROidQMr0wzq3D2mZwz81i5NCZ1-cOQbL5uUPpwOs3B4j0XIPtDb9AGWwpAkMvIyro-~Be~XC5VMq1dN0~JhZf7oqFWZy2SYRpkGuXDpqw2EUXzUX3BtAr~Ml3Kt30bennZI6NBRNIK921i~UHq-EJEQllrayi7jEKMohLZmBd3y5-4jYuMoCT1qulO83rivFdr6DiSUfP-QSRZ0R--NXIviQfIbMWUDJdtUu1PCPa0cLtK9xpNrjcthHEXhYOGK3oEpe-tlHF5V5hxKkMjusgKuTY5Ww6FJtnYPMf0ijUZgYVD3-5vmQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":511,"name":"Materials Science","url":"https://www.academia.edu/Documents/in/Materials_Science"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":17733,"name":"Nanotechnology","url":"https://www.academia.edu/Documents/in/Nanotechnology"},{"id":35267,"name":"Photoluminescence","url":"https://www.academia.edu/Documents/in/Photoluminescence"},{"id":44299,"name":"Optoelectronics","url":"https://www.academia.edu/Documents/in/Optoelectronics"},{"id":49651,"name":"Nano","url":"https://www.academia.edu/Documents/in/Nano"},{"id":743666,"name":"Langmuir","url":"https://www.academia.edu/Documents/in/Langmuir"},{"id":3604167,"name":"Meeting Abstracts","url":"https://www.academia.edu/Documents/in/Meeting_Abstracts"}],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="106200941"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/106200941/Structure_Based_Engineering_of_Methionine_Residues_in_the_Catalytic_Cores_of_Alkaline_Amylase_from_Alkalimonas_amylolytica_for_Improved_Oxidative_Stability"><img alt="Research paper thumbnail of Structure-Based Engineering of Methionine Residues in the Catalytic Cores of Alkaline Amylase from Alkalimonas amylolytica for Improved Oxidative Stability" class="work-thumbnail" src="https://attachments.academia-assets.com/105459368/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/106200941/Structure_Based_Engineering_of_Methionine_Residues_in_the_Catalytic_Cores_of_Alkaline_Amylase_from_Alkalimonas_amylolytica_for_Improved_Oxidative_Stability">Structure-Based Engineering of Methionine Residues in the Catalytic Cores of Alkaline Amylase from Alkalimonas amylolytica for Improved Oxidative Stability</a></div><div class="wp-workCard_item"><span>Applied and Environmental Microbiology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This work aims to improve the oxidative stability of alkaline amylase from Alkalimonas amylolytic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This work aims to improve the oxidative stability of alkaline amylase from Alkalimonas amylolytica through structure-based site-directed mutagenesis. Based on an analysis of the tertiary structure, five methionines (Met 145, Met 214, Met 229, Met 247, and Met 317) were selected as the mutation sites and individually replaced with leucine. In the presence of 500 mM H 2 O 2 at 35°C for 5 h, the wild-type enzyme and the M145L, M214L, M229L, M247L, and M317L mutants retained 10%, 28%, 46%, 28%, 72%, and 43% of the original activity, respectively. Concomitantly, the alkaline stability, thermal stability, and catalytic efficiency of the M247L mutant were also improved. The pH stability of the mutants (M145L, M214L, M229L, and M317L) remained unchanged compared to that of the wild-type enzyme, while the stable pH range of the M247L mutant was extended from pH 7.0 to 11.0 for the wild type to pH 6.0 to 12.0 for the mutant. The wild-type enzyme lost its activity after incubation at 50°C for ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="40f060ea6f8273cd0ab1050ac9ea2d45" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105459368,"asset_id":106200941,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105459368/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="106200941"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="106200941"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 106200941; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=106200941]").text(description); $(".js-view-count[data-work-id=106200941]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 106200941; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='106200941']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 106200941, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "40f060ea6f8273cd0ab1050ac9ea2d45" } } $('.js-work-strip[data-work-id=106200941]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":106200941,"title":"Structure-Based Engineering of Methionine Residues in the Catalytic Cores of Alkaline Amylase from Alkalimonas amylolytica for Improved Oxidative Stability","translated_title":"","metadata":{"abstract":"This work aims to improve the oxidative stability of alkaline amylase from Alkalimonas amylolytica through structure-based site-directed mutagenesis. Based on an analysis of the tertiary structure, five methionines (Met 145, Met 214, Met 229, Met 247, and Met 317) were selected as the mutation sites and individually replaced with leucine. In the presence of 500 mM H 2 O 2 at 35°C for 5 h, the wild-type enzyme and the M145L, M214L, M229L, M247L, and M317L mutants retained 10%, 28%, 46%, 28%, 72%, and 43% of the original activity, respectively. Concomitantly, the alkaline stability, thermal stability, and catalytic efficiency of the M247L mutant were also improved. The pH stability of the mutants (M145L, M214L, M229L, and M317L) remained unchanged compared to that of the wild-type enzyme, while the stable pH range of the M247L mutant was extended from pH 7.0 to 11.0 for the wild type to pH 6.0 to 12.0 for the mutant. The wild-type enzyme lost its activity after incubation at 50°C for ...","publisher":"American Society for Microbiology","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Applied and Environmental Microbiology"},"translated_abstract":"This work aims to improve the oxidative stability of alkaline amylase from Alkalimonas amylolytica through structure-based site-directed mutagenesis. Based on an analysis of the tertiary structure, five methionines (Met 145, Met 214, Met 229, Met 247, and Met 317) were selected as the mutation sites and individually replaced with leucine. In the presence of 500 mM H 2 O 2 at 35°C for 5 h, the wild-type enzyme and the M145L, M214L, M229L, M247L, and M317L mutants retained 10%, 28%, 46%, 28%, 72%, and 43% of the original activity, respectively. Concomitantly, the alkaline stability, thermal stability, and catalytic efficiency of the M247L mutant were also improved. The pH stability of the mutants (M145L, M214L, M229L, and M317L) remained unchanged compared to that of the wild-type enzyme, while the stable pH range of the M247L mutant was extended from pH 7.0 to 11.0 for the wild type to pH 6.0 to 12.0 for the mutant. The wild-type enzyme lost its activity after incubation at 50°C for ...","internal_url":"https://www.academia.edu/106200941/Structure_Based_Engineering_of_Methionine_Residues_in_the_Catalytic_Cores_of_Alkaline_Amylase_from_Alkalimonas_amylolytica_for_Improved_Oxidative_Stability","translated_internal_url":"","created_at":"2023-09-02T06:57:30.863-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38560448,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":105459368,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105459368/thumbnails/1.jpg","file_name":"AEM.pdf","download_url":"https://www.academia.edu/attachments/105459368/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Structure_Based_Engineering_of_Methionin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105459368/AEM-libre.pdf?1693666572=\u0026response-content-disposition=attachment%3B+filename%3DStructure_Based_Engineering_of_Methionin.pdf\u0026Expires=1732780219\u0026Signature=O6AuovrAcuzNDgUhK4D7~i96~1D6ZcaTLEdGb7kLi86Kab1dHIOgytvclyHuX~npNgdk1ejWvDhkLw2mbNykSQ5UEPodmEyCiYtvZNsMMp5Ku7HYS6FrPJZDv2tBfft3hdNntsYSQgKwHRFYDRaywdp3A1QL6J8Q-wxDBOauP2Rwz-i5iQ3UQ6RQ-YYm4jrClkWRkiAUG-9gGiObld-lEqFNESIv6~Z8jMj5pRwxEOHDq-ZMFAJahhnxiP7h63zXzockQFY1vd6~UszIpcsrwJZBRtHQZ3CpqB~oDpXfTPGvQlk6ubo798pIbas59FqcQUX4IoAQqP~V1KQu1Niveg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Structure_Based_Engineering_of_Methionine_Residues_in_the_Catalytic_Cores_of_Alkaline_Amylase_from_Alkalimonas_amylolytica_for_Improved_Oxidative_Stability","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":38560448,"first_name":"Nam","middle_initials":null,"last_name":"Wang","page_name":"NamWang","domain_name":"umcp","created_at":"2015-11-17T12:28:19.888-08:00","display_name":"Nam Wang","url":"https://umcp.academia.edu/NamWang"},"attachments":[{"id":105459368,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105459368/thumbnails/1.jpg","file_name":"AEM.pdf","download_url":"https://www.academia.edu/attachments/105459368/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Structure_Based_Engineering_of_Methionin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105459368/AEM-libre.pdf?1693666572=\u0026response-content-disposition=attachment%3B+filename%3DStructure_Based_Engineering_of_Methionin.pdf\u0026Expires=1732780219\u0026Signature=O6AuovrAcuzNDgUhK4D7~i96~1D6ZcaTLEdGb7kLi86Kab1dHIOgytvclyHuX~npNgdk1ejWvDhkLw2mbNykSQ5UEPodmEyCiYtvZNsMMp5Ku7HYS6FrPJZDv2tBfft3hdNntsYSQgKwHRFYDRaywdp3A1QL6J8Q-wxDBOauP2Rwz-i5iQ3UQ6RQ-YYm4jrClkWRkiAUG-9gGiObld-lEqFNESIv6~Z8jMj5pRwxEOHDq-ZMFAJahhnxiP7h63zXzockQFY1vd6~UszIpcsrwJZBRtHQZ3CpqB~oDpXfTPGvQlk6ubo798pIbas59FqcQUX4IoAQqP~V1KQu1Niveg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":145,"name":"Biochemistry","url":"https://www.academia.edu/Documents/in/Biochemistry"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":35607,"name":"Biocatalysis","url":"https://www.academia.edu/Documents/in/Biocatalysis"},{"id":67401,"name":"Mutagenesis","url":"https://www.academia.edu/Documents/in/Mutagenesis"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation"},{"id":107664,"name":"Applied Environmental Microbiology","url":"https://www.academia.edu/Documents/in/Applied_Environmental_Microbiology"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme"},{"id":419369,"name":"Methionine","url":"https://www.academia.edu/Documents/in/Methionine"},{"id":564340,"name":"Surface Active Agents","url":"https://www.academia.edu/Documents/in/Surface_Active_Agents"},{"id":954248,"name":"Detergents","url":"https://www.academia.edu/Documents/in/Detergents"},{"id":1256747,"name":"Oxidation-Reduction","url":"https://www.academia.edu/Documents/in/Oxidation-Reduction"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data"},{"id":4140753,"name":"amylases","url":"https://www.academia.edu/Documents/in/amylases"}],"urls":[{"id":33739269,"url":"https://journals.asm.org/doi/pdf/10.1128/AEM.01307-12"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99400233"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99400233/Effect_of_background_fluorophores_on_the_NADH_fluorescence_probe_signal"><img alt="Research paper thumbnail of Effect of background fluorophores on the NADH fluorescence probe signal" class="work-thumbnail" src="https://attachments.academia-assets.com/100541563/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99400233/Effect_of_background_fluorophores_on_the_NADH_fluorescence_probe_signal">Effect of background fluorophores on the NADH fluorescence probe signal</a></div><div class="wp-workCard_item"><span>Biotechnology Techniques</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Analysis of the errors caused by a drift in background fluorescence is performed for a fluorescen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Analysis of the errors caused by a drift in background fluorescence is performed for a fluorescence probe operated in a backscatter configuration. In some cases, significant errors can result if changes in background fluorophores during the course of fermentation are not accounted for. It is shown that the probe's sensitivity to background fluorophores must be considered to calibrate a fluorescence probe properly.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c4b90078da5ea3596d197be0a9f1ba93" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":100541563,"asset_id":99400233,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/100541563/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99400233"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99400233"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99400233; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=99400233]").text(description); $(".js-view-count[data-work-id=99400233]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 99400233; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='99400233']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 99400233, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c4b90078da5ea3596d197be0a9f1ba93" } } $('.js-work-strip[data-work-id=99400233]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":99400233,"title":"Effect of background fluorophores on the NADH fluorescence probe signal","translated_title":"","metadata":{"doi":"10.1007/BF02438655","volume":"5","abstract":"Analysis of the errors caused by a drift in background fluorescence is performed for a fluorescence probe operated in a backscatter configuration. In some cases, significant errors can result if changes in background fluorophores during the course of fermentation are not accounted for. It is shown that the probe's sensitivity to background fluorophores must be considered to calibrate a fluorescence probe properly.","publisher":"Springer Nature","page_numbers":"241-246","publication_date":{"day":null,"month":null,"year":1991,"errors":{}},"publication_name":"Biotechnology Techniques"},"translated_abstract":"Analysis of the errors caused by a drift in background fluorescence is performed for a fluorescence probe operated in a backscatter configuration. In some cases, significant errors can result if changes in background fluorophores during the course of fermentation are not accounted for. It is shown that the probe's sensitivity to background fluorophores must be considered to calibrate a fluorescence probe properly.","internal_url":"https://www.academia.edu/99400233/Effect_of_background_fluorophores_on_the_NADH_fluorescence_probe_signal","translated_internal_url":"","created_at":"2023-03-31T07:22:14.588-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38560448,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":100541563,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/100541563/thumbnails/1.jpg","file_name":"SimmonsMichael_EffectOfBackgroundFluorephores.pdf","download_url":"https://www.academia.edu/attachments/100541563/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_background_fluorophores_on_the.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/100541563/SimmonsMichael_EffectOfBackgroundFluorephores-libre.pdf?1680359967=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_background_fluorophores_on_the.pdf\u0026Expires=1732780219\u0026Signature=KYsZ3ekhAiiP0nGgaVmikogZg~KwBOLJj67amdqYzpf~JKvzN2aUmTQSth40Fc1EBLcdddYRf0x7qI9zMByZKt48rpuAA5TroPlZuiwBIOH9XB1N-bt7ufOmCEnAV~swmf9ud59ELHZnBZJMd99aVjAHWybMC5oS8nZ8HWwpTJTUIONNkaLEsz6GIZIxJ~vmH9jv5C-rh3uTB32Vqx1aSZjghwefThv2qZ3mXvjvS5QOZxWV0FGSIfFqwca8Vxa4LJiDtXGu0~NTOcNw4drQljFS9GmkYP5O4NxtqpouMq-5zs7~PW~7acn~ocVUOYO2K2S6awlfAVfgsk3WHQwUBA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effect_of_background_fluorophores_on_the_NADH_fluorescence_probe_signal","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":38560448,"first_name":"Nam","middle_initials":null,"last_name":"Wang","page_name":"NamWang","domain_name":"umcp","created_at":"2015-11-17T12:28:19.888-08:00","display_name":"Nam Wang","url":"https://umcp.academia.edu/NamWang"},"attachments":[{"id":100541563,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/100541563/thumbnails/1.jpg","file_name":"SimmonsMichael_EffectOfBackgroundFluorephores.pdf","download_url":"https://www.academia.edu/attachments/100541563/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_background_fluorophores_on_the.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/100541563/SimmonsMichael_EffectOfBackgroundFluorephores-libre.pdf?1680359967=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_background_fluorophores_on_the.pdf\u0026Expires=1732780219\u0026Signature=KYsZ3ekhAiiP0nGgaVmikogZg~KwBOLJj67amdqYzpf~JKvzN2aUmTQSth40Fc1EBLcdddYRf0x7qI9zMByZKt48rpuAA5TroPlZuiwBIOH9XB1N-bt7ufOmCEnAV~swmf9ud59ELHZnBZJMd99aVjAHWybMC5oS8nZ8HWwpTJTUIONNkaLEsz6GIZIxJ~vmH9jv5C-rh3uTB32Vqx1aSZjghwefThv2qZ3mXvjvS5QOZxWV0FGSIfFqwca8Vxa4LJiDtXGu0~NTOcNw4drQljFS9GmkYP5O4NxtqpouMq-5zs7~PW~7acn~ocVUOYO2K2S6awlfAVfgsk3WHQwUBA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":923,"name":"Technology","url":"https://www.academia.edu/Documents/in/Technology"},{"id":7698,"name":"Fluorescence","url":"https://www.academia.edu/Documents/in/Fluorescence"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"}],"urls":[{"id":30251245,"url":"https://link.springer.com/article/10.1007/BF02438655"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="92433507"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/92433507/A_method_of_variables_selection_for_soft_sensor_bas_ed_on_distributed_mutual_information"><img alt="Research paper thumbnail of A method of variables selection for soft sensor bas ed on distributed mutual information" class="work-thumbnail" src="https://attachments.academia-assets.com/95443064/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/92433507/A_method_of_variables_selection_for_soft_sensor_bas_ed_on_distributed_mutual_information">A method of variables selection for soft sensor bas ed on distributed mutual information</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A method of distributed mutual information is propo sed for selecting secondary variables in a so...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A method of distributed mutual information is propo sed for selecting secondary variables in a soft sen sor. The mutual information between the predicted primary va riable and the secondary variables is obtained by e stimating the probability distribution of every secondary var iable and the predicted variable. This information indirectly reflects the linear or nonlinear correlations betwe en the predicted variable and the secondary variabl es. A threshold value is obtained by t-test approach as a criterion to judge the correlation of variables. Subsequentl y, the variables whose mutual information is greater than the thresh old value are further screened to be selected as th e relevant variables or to be discarded as weakly relevant var iables. Finally, a soft sensor model is built based on the support vector machine algorithm with the selected secondar y variables.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5e70e491d5ede9d9e6445f3538b79d6e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95443064,"asset_id":92433507,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95443064/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92433507"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92433507"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92433507; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92433507]").text(description); $(".js-view-count[data-work-id=92433507]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92433507; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92433507']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 92433507, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5e70e491d5ede9d9e6445f3538b79d6e" } } $('.js-work-strip[data-work-id=92433507]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92433507,"title":"A method of variables selection for soft sensor bas ed on distributed mutual information","translated_title":"","metadata":{"abstract":"A method of distributed mutual information is propo sed for selecting secondary variables in a soft sen sor. The mutual information between the predicted primary va riable and the secondary variables is obtained by e stimating the probability distribution of every secondary var iable and the predicted variable. This information indirectly reflects the linear or nonlinear correlations betwe en the predicted variable and the secondary variabl es. A threshold value is obtained by t-test approach as a criterion to judge the correlation of variables. Subsequentl y, the variables whose mutual information is greater than the thresh old value are further screened to be selected as th e relevant variables or to be discarded as weakly relevant var iables. Finally, a soft sensor model is built based on the support vector machine algorithm with the selected secondar y variables.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"A method of distributed mutual information is propo sed for selecting secondary variables in a soft sen sor. The mutual information between the predicted primary va riable and the secondary variables is obtained by e stimating the probability distribution of every secondary var iable and the predicted variable. This information indirectly reflects the linear or nonlinear correlations betwe en the predicted variable and the secondary variabl es. A threshold value is obtained by t-test approach as a criterion to judge the correlation of variables. Subsequentl y, the variables whose mutual information is greater than the thresh old value are further screened to be selected as th e relevant variables or to be discarded as weakly relevant var iables. Finally, a soft sensor model is built based on the support vector machine algorithm with the selected secondar y variables.","internal_url":"https://www.academia.edu/92433507/A_method_of_variables_selection_for_soft_sensor_bas_ed_on_distributed_mutual_information","translated_internal_url":"","created_at":"2022-12-08T07:42:41.094-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38560448,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":95443064,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/95443064/thumbnails/1.jpg","file_name":"a-method-of-variables-selection-for-soft-sensor-based-on-distributedmutual-information.pdf","download_url":"https://www.academia.edu/attachments/95443064/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_method_of_variables_selection_for_soft.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/95443064/a-method-of-variables-selection-for-soft-sensor-based-on-distributedmutual-information-libre.pdf?1670514472=\u0026response-content-disposition=attachment%3B+filename%3DA_method_of_variables_selection_for_soft.pdf\u0026Expires=1732780219\u0026Signature=b4yzdquxElxrYJnNwgviqLmhhlU~p~FUK6yrrIH1qEW1RcTlfNnyX--tG1y7gHHdIDXSeRdYeVIVUc5hcWb2RoMAr0XXpwMQm1NNJ~dD~SwbznnZQ1rxhjtjDlaZjPVWVtlVVEYUj9iGQBHFUzcHiwKnigIztWv66kIFGdkXsFPC7NjJYoZV1pGRMmbJfAjewCFVWgHd9Qy33dk7f42J6IJEPfE4goXc0xyv3Zurb81jk3qpuQ0WBBf3laQ1VbvdsV633lLcCnAZf~uEbjBEqBUHElJyazd6NkIdmn9hPXiopOyW97KfysfLyKATeqERNolwF0lMryUrD5tXX-WdXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_method_of_variables_selection_for_soft_sensor_bas_ed_on_distributed_mutual_information","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":38560448,"first_name":"Nam","middle_initials":null,"last_name":"Wang","page_name":"NamWang","domain_name":"umcp","created_at":"2015-11-17T12:28:19.888-08:00","display_name":"Nam Wang","url":"https://umcp.academia.edu/NamWang"},"attachments":[{"id":95443064,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/95443064/thumbnails/1.jpg","file_name":"a-method-of-variables-selection-for-soft-sensor-based-on-distributedmutual-information.pdf","download_url":"https://www.academia.edu/attachments/95443064/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_method_of_variables_selection_for_soft.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/95443064/a-method-of-variables-selection-for-soft-sensor-based-on-distributedmutual-information-libre.pdf?1670514472=\u0026response-content-disposition=attachment%3B+filename%3DA_method_of_variables_selection_for_soft.pdf\u0026Expires=1732780219\u0026Signature=b4yzdquxElxrYJnNwgviqLmhhlU~p~FUK6yrrIH1qEW1RcTlfNnyX--tG1y7gHHdIDXSeRdYeVIVUc5hcWb2RoMAr0XXpwMQm1NNJ~dD~SwbznnZQ1rxhjtjDlaZjPVWVtlVVEYUj9iGQBHFUzcHiwKnigIztWv66kIFGdkXsFPC7NjJYoZV1pGRMmbJfAjewCFVWgHd9Qy33dk7f42J6IJEPfE4goXc0xyv3Zurb81jk3qpuQ0WBBf3laQ1VbvdsV633lLcCnAZf~uEbjBEqBUHElJyazd6NkIdmn9hPXiopOyW97KfysfLyKATeqERNolwF0lMryUrD5tXX-WdXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":300,"name":"Mathematics","url":"https://www.academia.edu/Documents/in/Mathematics"},{"id":892,"name":"Statistics","url":"https://www.academia.edu/Documents/in/Statistics"},{"id":43619,"name":"Feature Selection","url":"https://www.academia.edu/Documents/in/Feature_Selection"},{"id":164706,"name":"Mutual Information","url":"https://www.academia.edu/Documents/in/Mutual_Information"}],"urls":[{"id":26800752,"url":"http://www.jocpr.com/articles/a-method-of-variables-selection-for-soft-sensor-based-on-distributedmutual-information.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="92433506"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/92433506/Effect_of_Carbon_Chain_Length_Ionic_Strength_and_pH_on_the_In_Vitro_Release_Kinetics_of_Cationic_Drugs_from_Fatty_Acid_Loaded_Contact_Lenses"><img alt="Research paper thumbnail of Effect of Carbon Chain Length, Ionic Strength, and pH on the In Vitro Release Kinetics of Cationic Drugs from Fatty-Acid-Loaded Contact Lenses" class="work-thumbnail" src="https://attachments.academia-assets.com/95443062/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/92433506/Effect_of_Carbon_Chain_Length_Ionic_Strength_and_pH_on_the_In_Vitro_Release_Kinetics_of_Cationic_Drugs_from_Fatty_Acid_Loaded_Contact_Lenses">Effect of Carbon Chain Length, Ionic Strength, and pH on the In Vitro Release Kinetics of Cationic Drugs from Fatty-Acid-Loaded Contact Lenses</a></div><div class="wp-workCard_item"><span>Pharmaceutics</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This paper explores the use of fatty acids in silicone hydrogel contact lenses for extending the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This paper explores the use of fatty acids in silicone hydrogel contact lenses for extending the release duration of cationic drugs. Drug release kinetics was dependent on the carbon chain length of the fatty acid loaded in the lens, with 12-, 14- and 18-carbon chain length fatty acids increasing the uptake and the release duration of ketotifen fumarate (KTF) and tetracaine hydrochloride (THCL). Drug release kinetics from oleic acid-loaded lenses was evaluated in phosphate buffer saline (PBS) at different ionic strengths (I = 167, 500, 1665 mM); the release duration of KTF and THCL was decreased with increasing ionic strength of the release medium. Furthermore, the release of KTF and THCL in deionized water did not show a burst and was significantly slower compared to that in PBS. The release kinetics of KTF and THCL was significantly faster when the pH of the release medium was decreased from 7.4 towards 5.5 because of the decrease in the relative amounts of oleate anions in the le...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8891449d6c727ab7f149feea3f65e9e3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95443062,"asset_id":92433506,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95443062/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92433506"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92433506"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92433506; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92433506]").text(description); $(".js-view-count[data-work-id=92433506]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92433506; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92433506']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 92433506, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8891449d6c727ab7f149feea3f65e9e3" } } $('.js-work-strip[data-work-id=92433506]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92433506,"title":"Effect of Carbon Chain Length, Ionic Strength, and pH on the In Vitro Release Kinetics of Cationic Drugs from Fatty-Acid-Loaded Contact Lenses","translated_title":"","metadata":{"abstract":"This paper explores the use of fatty acids in silicone hydrogel contact lenses for extending the release duration of cationic drugs. Drug release kinetics was dependent on the carbon chain length of the fatty acid loaded in the lens, with 12-, 14- and 18-carbon chain length fatty acids increasing the uptake and the release duration of ketotifen fumarate (KTF) and tetracaine hydrochloride (THCL). Drug release kinetics from oleic acid-loaded lenses was evaluated in phosphate buffer saline (PBS) at different ionic strengths (I = 167, 500, 1665 mM); the release duration of KTF and THCL was decreased with increasing ionic strength of the release medium. Furthermore, the release of KTF and THCL in deionized water did not show a burst and was significantly slower compared to that in PBS. The release kinetics of KTF and THCL was significantly faster when the pH of the release medium was decreased from 7.4 towards 5.5 because of the decrease in the relative amounts of oleate anions in the le...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Pharmaceutics"},"translated_abstract":"This paper explores the use of fatty acids in silicone hydrogel contact lenses for extending the release duration of cationic drugs. Drug release kinetics was dependent on the carbon chain length of the fatty acid loaded in the lens, with 12-, 14- and 18-carbon chain length fatty acids increasing the uptake and the release duration of ketotifen fumarate (KTF) and tetracaine hydrochloride (THCL). Drug release kinetics from oleic acid-loaded lenses was evaluated in phosphate buffer saline (PBS) at different ionic strengths (I = 167, 500, 1665 mM); the release duration of KTF and THCL was decreased with increasing ionic strength of the release medium. Furthermore, the release of KTF and THCL in deionized water did not show a burst and was significantly slower compared to that in PBS. The release kinetics of KTF and THCL was significantly faster when the pH of the release medium was decreased from 7.4 towards 5.5 because of the decrease in the relative amounts of oleate anions in the le...","internal_url":"https://www.academia.edu/92433506/Effect_of_Carbon_Chain_Length_Ionic_Strength_and_pH_on_the_In_Vitro_Release_Kinetics_of_Cationic_Drugs_from_Fatty_Acid_Loaded_Contact_Lenses","translated_internal_url":"","created_at":"2022-12-08T07:42:40.920-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38560448,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":95443062,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/95443062/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/95443062/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_Carbon_Chain_Length_Ionic_Stre.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/95443062/pdf-libre.pdf?1670514485=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_Carbon_Chain_Length_Ionic_Stre.pdf\u0026Expires=1732780219\u0026Signature=Cp4fNVwil3vQ9XExEC-aO-rPjwPGLdRQSRFUmFKo~qLLzAC75AMwnGhuOypIpuluxcRPPS5CZpgzsUY6wWPX9uzQPjYQ73MNnti1sA15xT1J5epBPHMyPIZfMQGkja52PPW7gf02occkHmGwqK5XjuUzGnEO9w4KXfjJtibrCr5JiifDAzs4gl1DrF4ZMhpb3HIB81YssrCbXdWddJloLmRjllZai~Co2FG3Fryl6~iW~SsJ1bQ9X0wB~S2HGLJh~RvHTksWDJ-BfY4NfxsXTvvnI6SdTtGu2lM3v4lYu6meOX6GMx9bLtCpBjgOxxpemB9OnQDlHq0hTAClM7ZzuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effect_of_Carbon_Chain_Length_Ionic_Strength_and_pH_on_the_In_Vitro_Release_Kinetics_of_Cationic_Drugs_from_Fatty_Acid_Loaded_Contact_Lenses","translated_slug":"","page_count":18,"language":"en","content_type":"Work","owner":{"id":38560448,"first_name":"Nam","middle_initials":null,"last_name":"Wang","page_name":"NamWang","domain_name":"umcp","created_at":"2015-11-17T12:28:19.888-08:00","display_name":"Nam Wang","url":"https://umcp.academia.edu/NamWang"},"attachments":[{"id":95443062,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/95443062/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/95443062/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_Carbon_Chain_Length_Ionic_Stre.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/95443062/pdf-libre.pdf?1670514485=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_Carbon_Chain_Length_Ionic_Stre.pdf\u0026Expires=1732780219\u0026Signature=Cp4fNVwil3vQ9XExEC-aO-rPjwPGLdRQSRFUmFKo~qLLzAC75AMwnGhuOypIpuluxcRPPS5CZpgzsUY6wWPX9uzQPjYQ73MNnti1sA15xT1J5epBPHMyPIZfMQGkja52PPW7gf02occkHmGwqK5XjuUzGnEO9w4KXfjJtibrCr5JiifDAzs4gl1DrF4ZMhpb3HIB81YssrCbXdWddJloLmRjllZai~Co2FG3Fryl6~iW~SsJ1bQ9X0wB~S2HGLJh~RvHTksWDJ-BfY4NfxsXTvvnI6SdTtGu2lM3v4lYu6meOX6GMx9bLtCpBjgOxxpemB9OnQDlHq0hTAClM7ZzuQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":41745,"name":"Pharmaceutics","url":"https://www.academia.edu/Documents/in/Pharmaceutics"},{"id":92344,"name":"Contact Lens","url":"https://www.academia.edu/Documents/in/Contact_Lens"},{"id":102409,"name":"Cationic polymerization","url":"https://www.academia.edu/Documents/in/Cationic_polymerization"},{"id":725266,"name":"Oleic Acid","url":"https://www.academia.edu/Documents/in/Oleic_Acid"},{"id":970774,"name":"Ionic Strength","url":"https://www.academia.edu/Documents/in/Ionic_Strength"}],"urls":[{"id":26800751,"url":"https://www.mdpi.com/1999-4923/13/7/1060/pdf"}]}, dispatcherData: dispatcherData }); 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Visual Science</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ea91e3d37e422b9e5593bfb72bc0c3c3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95443107,"asset_id":92433502,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95443107/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92433502"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92433502"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92433502; 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The ability of an episcleral implant at the equator of the eye to deliver drugs to the posterior segment was evaluated, using a sustained-release implant containing gadolinium-DTPA (Gd-DTPA). The movement of this drug surrogate was assessed with magnetic resonance imaging (MRI) in the rabbit eye. The results were compared with a similar implant placed in the vitreous cavity through a scleral incision at the equator. METHODS. Polymer-based implants releasing Gd-DTPA were manufactured and placed in the subconjunctival space on the episclera or in the vitreous cavity in live rabbit eyes (in vivo) and in freshly enucleated eyes (ex vivo). Release rates of implants in vitro were also determined. Dynamic three-dimensional MRI was performed using a 4.7-Tesla MRI system for 8 hours. MR images were developed and analyzed on computer. RESULTS. Episcleral implants in vivo delivered a mean total of 2.7 g Gd-DTPA into the vitreous, representing only 0.12% of the total amount of compound released from the implant in vitro. No Gd-DTPA was detected in the posterior segment of the eye. Ex vivo, the Gd-DTPA concentration in the vitreous was 30 times higher. In vivo eyes with intravitreal implants placed at the equator delivered Gd-DTPA throughout the vitreous cavity and posterior segment. Compartmental analysis of the ocular drug distribution from an episcleral implant showed that the elimination rate constant of Gd-DTPA from the subconjunctival space into the episcleral veins and conjunctival lymphatics was 3-log units higher than the transport rate constant for Gd-DTPA movement into the vitreous. CONCLUSIONS. In vivo, episcleral implants at the equator of the eye did not deliver a significant amount of Gd-DTPA into the vitreous, and no compound was identified in the posterior segment. A 30-fold increase in vitreous Gd-DTPA concentration occurred in the enucleated eyes, suggesting that there are significant barriers to the movement of drugs from the episcleral space into the vitreous in vivo. Dynamic three-dimensional MRI using Gd-DTPA, and possibly other contrast agents, may be useful in understanding the spatial relationships of ocular drug distribution and clearance mechanisms in the eye.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Investigative Opthalmology \u0026amp; Visual 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Wang","url":"https://umcp.academia.edu/NamWang"},"attachments":[{"id":95443107,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/95443107/thumbnails/1.jpg","file_name":"z7g00804002722.pdf","download_url":"https://www.academia.edu/attachments/95443107/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Controlled_Drug_Release_from_an_Ocular_I.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/95443107/z7g00804002722-libre.pdf?1670514476=\u0026response-content-disposition=attachment%3B+filename%3DControlled_Drug_Release_from_an_Ocular_I.pdf\u0026Expires=1732780219\u0026Signature=DrmPbhw8H57lIR~TSoq0DdMNJnqPNTJUMMTfNGQE57lSsH9t3Y~UO85-7BwLmARlKk8rFkyC60nPafq3AT4yR5Wh2GHTUXR1FtwpzRVxFyj5mNBj63bNZT0YI93Hcrkx82xUrJz50exjWAs-eCf5dcrRam~BV58WKyvDyWVkVyt27sFtT-0xq4ytxyy~d83Zcn96bxOU8CG0Zvm-VCcRVlzYShoQ3sPEXcP-0QwlcVNqWrR2iRkzoj7kzihWoU6te3MptTsDHXNa2rNUUXa0zVDKHwyqdjiZMYTEa6wZFBLz7wTCdD2F5ppi9xyZLgSpxx4W5gO92CcF~2f5DqX2KQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6200,"name":"Magnetic 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="92433501"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/92433501/Assessment_of_Subconjunctival_and_Intrascleral_Drug_Delivery_to_the_Posterior_Segment_Using_Dynamic_Contrast_Enhanced_Magnetic_Resonance_Imaging"><img alt="Research paper thumbnail of Assessment of Subconjunctival and Intrascleral Drug Delivery to the Posterior Segment Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging" class="work-thumbnail" src="https://attachments.academia-assets.com/95443103/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/92433501/Assessment_of_Subconjunctival_and_Intrascleral_Drug_Delivery_to_the_Posterior_Segment_Using_Dynamic_Contrast_Enhanced_Magnetic_Resonance_Imaging">Assessment of Subconjunctival and Intrascleral Drug Delivery to the Posterior Segment Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging</a></div><div class="wp-workCard_item"><span>Investigative Opthalmology &amp; Visual Science</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="88943e055ff4cf29d427dcab2046fc31" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95443103,"asset_id":92433501,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95443103/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92433501"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92433501"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92433501; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92433501]").text(description); $(".js-view-count[data-work-id=92433501]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92433501; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92433501']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 92433501, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "88943e055ff4cf29d427dcab2046fc31" } } $('.js-work-strip[data-work-id=92433501]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92433501,"title":"Assessment of Subconjunctival and Intrascleral Drug Delivery to the Posterior Segment Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging","translated_title":"","metadata":{"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","ai_title_tag":"Intrascleral Gd-DTPA Delivery to the Eye Posterior Segment","grobid_abstract":"PURPOSE. Sustained-release intravitreal drug implants for posterior segment diseases are associated with significant complications. As an alternative, subconjunctival infusions of drug to the episclera of the back of the eye have been performed, but results in clinical trials for macular diseases showed mixed results. To improve understanding of transscleral drug delivery to the posterior segment, the distribution and clearance of gadolinium-diethylenetriaminopentaacetic acid (Gd-DTPA) infused in the subconjunctival or intrascleral space was investigated by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). METHODS. In anesthetized rabbits, catheters were placed anteriorly in the subconjunctival or intrascleral space and infused with Gd-DTPA at 1 and 10 L/min. Distribution and clearance of Gd-DTPA were measured using DCE-MRI. Histologic examination was performed to assess ocular toxicity of the delivery system. RESULTS. Subconjunctival infusions failed to produce detectable levels of Gd-DTPA in the back of the eye. In contrast, intrascleral infusions expanded the suprachoroidal layer and delivered Gd-DTPA to the posterior segment. Suprachoroidal clearance of Gd-DTPA followed first-order kinetics with an average half-life of 5.4 and 11.8 minutes after intrascleral infusions at 1 and 10 L/min, respectively. Histologic examination demonstrated expansion of the tissues in the suprachoroidal space that normalized after infusion termination. CONCLUSIONS. An intrascleral infusion was successful in transporting Gd-DTPA to the posterior segment from an anterior infusion site with limited anterior segment exposure. The suprachoroidal space appears to be an expandible conduit for drug transport to the posterior segment. Further studies are indicated to explore the feasibility of clinical applications.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Investigative Opthalmology \u0026amp; Visual Science","grobid_abstract_attachment_id":95443103},"translated_abstract":null,"internal_url":"https://www.academia.edu/92433501/Assessment_of_Subconjunctival_and_Intrascleral_Drug_Delivery_to_the_Posterior_Segment_Using_Dynamic_Contrast_Enhanced_Magnetic_Resonance_Imaging","translated_internal_url":"","created_at":"2022-12-08T07:42:39.981-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38560448,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":95443103,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/95443103/thumbnails/1.jpg","file_name":"aaab0e1fe5d9f49bbfaa8823a15c5cead821.pdf","download_url":"https://www.academia.edu/attachments/95443103/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Assessment_of_Subconjunctival_and_Intras.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/95443103/aaab0e1fe5d9f49bbfaa8823a15c5cead821.pdf?1670514246=\u0026response-content-disposition=attachment%3B+filename%3DAssessment_of_Subconjunctival_and_Intras.pdf\u0026Expires=1732780219\u0026Signature=ds0WbY3GOp5qmsUdpDecfYEVnPU5NDacsBWNxZHzzlC7LxzyRBrA1aV3mBCXNnxAchemH82Ck67NvtY81y0Yg5VR9ziDVveqgTAo-EKfo34f1-fk60lWSvMME6h65LydfGw3wVjMVutPkm~6QkKcliDN1wMI9Q6CaTlkwTRPZZETNOwp8ZCYnNnPmoXwN8doybjbBdOqLSAGc4i2Pqz7tXm49xXPsyoa800rU008ruFmkZ-Ob4GMHQICs3oQFVNiMU~dtnBVt84q67cQjkq9-GkscMKOXLcHAPHL36lpV3OECRS620q-10gZRUkO~XSHQGYFXvlRYAOsyqqzdkVCwQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Assessment_of_Subconjunctival_and_Intrascleral_Drug_Delivery_to_the_Posterior_Segment_Using_Dynamic_Contrast_Enhanced_Magnetic_Resonance_Imaging","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":38560448,"first_name":"Nam","middle_initials":null,"last_name":"Wang","page_name":"NamWang","domain_name":"umcp","created_at":"2015-11-17T12:28:19.888-08:00","display_name":"Nam Wang","url":"https://umcp.academia.edu/NamWang"},"attachments":[{"id":95443103,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/95443103/thumbnails/1.jpg","file_name":"aaab0e1fe5d9f49bbfaa8823a15c5cead821.pdf","download_url":"https://www.academia.edu/attachments/95443103/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Assessment_of_Subconjunctival_and_Intras.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/95443103/aaab0e1fe5d9f49bbfaa8823a15c5cead821.pdf?1670514246=\u0026response-content-disposition=attachment%3B+filename%3DAssessment_of_Subconjunctival_and_Intras.pdf\u0026Expires=1732780219\u0026Signature=ds0WbY3GOp5qmsUdpDecfYEVnPU5NDacsBWNxZHzzlC7LxzyRBrA1aV3mBCXNnxAchemH82Ck67NvtY81y0Yg5VR9ziDVveqgTAo-EKfo34f1-fk60lWSvMME6h65LydfGw3wVjMVutPkm~6QkKcliDN1wMI9Q6CaTlkwTRPZZETNOwp8ZCYnNnPmoXwN8doybjbBdOqLSAGc4i2Pqz7tXm49xXPsyoa800rU008ruFmkZ-Ob4GMHQICs3oQFVNiMU~dtnBVt84q67cQjkq9-GkscMKOXLcHAPHL36lpV3OECRS620q-10gZRUkO~XSHQGYFXvlRYAOsyqqzdkVCwQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging"},{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28404,"name":"Conjunctiva","url":"https://www.academia.edu/Documents/in/Conjunctiva"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":99872,"name":"Dynamic contrast enhanced MRI","url":"https://www.academia.edu/Documents/in/Dynamic_contrast_enhanced_MRI"},{"id":117200,"name":"Retina","url":"https://www.academia.edu/Documents/in/Retina"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems"},{"id":245634,"name":"Eye","url":"https://www.academia.edu/Documents/in/Eye"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":1407305,"name":"Contrast Media","url":"https://www.academia.edu/Documents/in/Contrast_Media"},{"id":2439414,"name":"Magnetic resonance image","url":"https://www.academia.edu/Documents/in/Magnetic_resonance_image"},{"id":2562017,"name":"Choroid","url":"https://www.academia.edu/Documents/in/Choroid"},{"id":3557622,"name":"sclera","url":"https://www.academia.edu/Documents/in/sclera"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":26800747,"url":"http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.06-0670"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="92433382"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/92433382/Study_of_Ocular_Transport_of_Drugs_Released_from_an_Intravitreal_Implant_Using_Magnetic_Resonance_Imaging"><img alt="Research paper thumbnail of Study of Ocular Transport of Drugs Released from an Intravitreal Implant Using Magnetic Resonance Imaging" class="work-thumbnail" src="https://attachments.academia-assets.com/95443095/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/92433382/Study_of_Ocular_Transport_of_Drugs_Released_from_an_Intravitreal_Implant_Using_Magnetic_Resonance_Imaging">Study of Ocular Transport of Drugs Released from an Intravitreal Implant Using Magnetic Resonance Imaging</a></div><div class="wp-workCard_item"><span>Annals of Biomedical Engineering</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f7df021ade517e21839fb8494c18baa" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95443095,"asset_id":92433382,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95443095/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92433382"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92433382"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92433382; 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This knowledge can guide the development of new drug delivery devices. In this study, we investigated the movement of a drug surrogate, Gd-DTPA (Magnevist ) released from a polymer-based implant in rabbit vitreous using T 1-weighted magnetic resonance imaging (MRI). Intensity values in the MRI data were converted to concentration by comparison with calibration samples. Concentration profiles approaching pseudosteady state showed gradients from the implant toward the retinal surface, suggesting that diffusion was occurring into the retinal-choroidal-scleral (RCS) membrane. Gd-DTPA concentration varied from high values near the implant to lower values distal to the implant. Such regional concentration differences throughout the vitreous may have clinical significance when attempting to treat ubiquitous eye diseases using a single positional implant. We developed a finite element mathematical model of the rabbit eye and compared the MRI experimental concentration data with simulation concentration profiles. The model utilized a diffusion coefficient of Gd-DTPA in the vitreous of 2.8 × 10 −6 cm 2 s −1 and yielded a diffusion coefficient for Gd-DTPA through the simulated composite posterior membrane (representing the retina-choroidsclera membrane) of 6.0 × 10 −8 cm 2 s −1. Since the model membrane was 0.03-cm thick, this resulted in an effective membrane permeability of 2.0 × 10 −6 cm s −1. Convective movement of Gd-DTPA was shown to have minimal effect on the concentration profiles since the Peclet number was 0.09 for this system.","publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Annals of Biomedical 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src="https://attachments.academia-assets.com/119712856/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125721358/Hydrolysis_of_wheat_starch_and_its_effect_on_the_Falling_Number_procedure_experimental_observations">Hydrolysis of wheat starch and its effect on the Falling Number procedure: experimental observations</a></div><div class="wp-workCard_item"><span>Journal of the Science of Food and Agriculture</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="23f9485307a68173e60b0e2c28a18d12" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":119712856,"asset_id":125721358,"asset_type":"Work","button_location":"profile"}" 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href="https://www.academia.edu/125721357/Monitoring_Polymerization_Reactions_by_Near_IR_Spectroscopy"><img alt="Research paper thumbnail of Monitoring Polymerization Reactions by Near-IR Spectroscopy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125721357/Monitoring_Polymerization_Reactions_by_Near_IR_Spectroscopy">Monitoring Polymerization Reactions by Near-IR Spectroscopy</a></div><div class="wp-workCard_item"><span>Acs Symposium Series</span><span>, May 5, 1995</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span 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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125721356/Spoilage_of_Milk_and_Dairy_Products">Spoilage of Milk and Dairy Products</a></div><div class="wp-workCard_item"><span>Elsevier eBooks</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Milk’s combination of water, fats, proteins, and vitamins allows for the growth of a variety of b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Milk’s combination of water, fats, proteins, and vitamins allows for the growth of a variety of bacteria, especially psychrotrophic bacteria that are able to grow under cold conditions. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120904433"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120904433/Extended_delivery_of_non_steroidal_anti_inflammatory_drugs_through_contact_lenses_loaded_with_Vitamin_E_and_cationic_surfactants"><img alt="Research paper thumbnail of Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants" class="work-thumbnail" src="https://attachments.academia-assets.com/115910870/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120904433/Extended_delivery_of_non_steroidal_anti_inflammatory_drugs_through_contact_lenses_loaded_with_Vitamin_E_and_cationic_surfactants">Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants</a></div><div class="wp-workCard_item"><span>Contact Lens and Anterior Eye</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="66d63cdd47066ac374ad399e61422e79" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115910870,"asset_id":120904433,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115910870/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120904433"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120904433"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120904433; 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In ACUVUE Oasys® and ACUVUE TruEye®, the release of ketorolac tromethamine and flurbiprofen sodium is extended from hours to several days for 11% and 21% vitamin E, (weight of vitamin E / weight of dry lens) but with a considerable reduction in the amount of drug released. Cetalkonium chloride and stearylamine increased the drug loading capacity which was otherwise compromised by the addition of vitamin E in the contact lenses. In the case of diclofenac sodium, a sustained release over 150 h for both contact lenses can be achieved. It was found that the release-time-increase factor due to vitamin E has a linear dependence with the octanol-water partition coefficient of the drug in ACUVUE Oasys®. The results in this study show that contact lenses loaded with vitamin E in conjunction with cationic surfactants achieved sustained release of non-steroidal anti-inflammatory drugs (NSAIDs) within the therapeutic window.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"Contact Lens and Anterior Eye","grobid_abstract_attachment_id":115910870},"translated_abstract":null,"internal_url":"https://www.academia.edu/120904433/Extended_delivery_of_non_steroidal_anti_inflammatory_drugs_through_contact_lenses_loaded_with_Vitamin_E_and_cationic_surfactants","translated_internal_url":"","created_at":"2024-06-12T01:17:25.840-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38560448,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115910870,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115910870/thumbnails/1.jpg","file_name":"j.clae.2019.04.01120240612-1-yd0yj0.pdf","download_url":"https://www.academia.edu/attachments/115910870/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Extended_delivery_of_non_steroidal_anti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115910870/j.clae.2019.04.01120240612-1-yd0yj0-libre.pdf?1718181088=\u0026response-content-disposition=attachment%3B+filename%3DExtended_delivery_of_non_steroidal_anti.pdf\u0026Expires=1732780219\u0026Signature=KULI7iHmPTFCYhHHehZiiZCc64tvb2c8bxCbLPbO~ypIJu5PNK27K5uJeeFV2CNX-Hx8bk0kb7tGI6G9KC0SqAP6b9tfXGrcP5SshpOIZV8KtvpXOynOldfUQQOgLayHFIMdUqaFpYNBADOX~wKbyoShhZcF28GQLpriRYLDuRFAlqPaJu-IQW3QIj4ApAWXo0Z8~T~GXs-fUSOq5RwicNCkVxW~OJTeGeL41TVN~L5uvzGk0iPczH-oCoLfcsBhX4vpFZmYaEbQrfLd9XzLAk2b2nQsDCoUA-sIi7VoiByz68QdfzUqZGmi3AjHzSd97WhACxPouEZjY3yn7mo7Jw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Extended_delivery_of_non_steroidal_anti_inflammatory_drugs_through_contact_lenses_loaded_with_Vitamin_E_and_cationic_surfactants","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":38560448,"first_name":"Nam","middle_initials":null,"last_name":"Wang","page_name":"NamWang","domain_name":"umcp","created_at":"2015-11-17T12:28:19.888-08:00","display_name":"Nam Wang","url":"https://umcp.academia.edu/NamWang"},"attachments":[{"id":115910870,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115910870/thumbnails/1.jpg","file_name":"j.clae.2019.04.01120240612-1-yd0yj0.pdf","download_url":"https://www.academia.edu/attachments/115910870/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Extended_delivery_of_non_steroidal_anti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115910870/j.clae.2019.04.01120240612-1-yd0yj0-libre.pdf?1718181088=\u0026response-content-disposition=attachment%3B+filename%3DExtended_delivery_of_non_steroidal_anti.pdf\u0026Expires=1732780219\u0026Signature=KULI7iHmPTFCYhHHehZiiZCc64tvb2c8bxCbLPbO~ypIJu5PNK27K5uJeeFV2CNX-Hx8bk0kb7tGI6G9KC0SqAP6b9tfXGrcP5SshpOIZV8KtvpXOynOldfUQQOgLayHFIMdUqaFpYNBADOX~wKbyoShhZcF28GQLpriRYLDuRFAlqPaJu-IQW3QIj4ApAWXo0Z8~T~GXs-fUSOq5RwicNCkVxW~OJTeGeL41TVN~L5uvzGk0iPczH-oCoLfcsBhX4vpFZmYaEbQrfLd9XzLAk2b2nQsDCoUA-sIi7VoiByz68QdfzUqZGmi3AjHzSd97WhACxPouEZjY3yn7mo7Jw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":264378,"name":"Vitamin","url":"https://www.academia.edu/Documents/in/Vitamin"},{"id":359001,"name":"Optometry and Ophthalmology","url":"https://www.academia.edu/Documents/in/Optometry_and_Ophthalmology"}],"urls":[{"id":42870652,"url":"https://api.elsevier.com/content/article/PII:S1367048418310361?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120904382"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120904382/Photo_Assisted_Tuning_of_Si_Nano_Crystal_Photoluminescence"><img alt="Research paper thumbnail of Photo-Assisted Tuning of Si Nano-Crystal Photoluminescence" class="work-thumbnail" src="https://attachments.academia-assets.com/115910825/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120904382/Photo_Assisted_Tuning_of_Si_Nano_Crystal_Photoluminescence">Photo-Assisted Tuning of Si Nano-Crystal Photoluminescence</a></div><div class="wp-workCard_item"><span>ECS Meeting Abstracts</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="51a9109d68af983235f76f8f5797651f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115910825,"asset_id":120904382,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115910825/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120904382"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120904382"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120904382; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "51a9109d68af983235f76f8f5797651f" } } $('.js-work-strip[data-work-id=120904382]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120904382,"title":"Photo-Assisted Tuning of Si Nano-Crystal Photoluminescence","translated_title":"","metadata":{"publisher":"The Electrochemical Society","grobid_abstract":"Silicon is a rather inefficient light emitter due to the indirect band gap electronic structure, requiring a phonon to balance the electron momentum during the interband transition. Fortunately, momentum requirements are relaxed in the 1-5 nm diameter Si crystals as a result of quantum confinement effects, and bright photoluminescence (PL) in the UV-vis range is achieved. Photoluminescent Si nanocrystals along with the C-and SiC-based nanoparticles are considered bioinert and may lead to the development of biocompatible and smaller probes than the well-known metal chalcogenide-based quantum dots. Published Si nanocrystal production procedures typically do not allow for the fine control of the particle size. An accepted way to make the H-terminated Si nanocrystals consists of anodic Si wafer etching with the subsequent breakup of the porous film in an ultrasound bath. Resulting H-termination provides a useful platform for further chemical derivatization and conjugation to biomolecules. However, a rather polydisperse mixture is produced following the ultrasonic treatment, leading to the distributed band gap energies and the extent of surface passivation. From the technological point of view, a homogeneous nanoparticle size mixture is highly desirable. In this study, we offer an efficient way to reduce the H-terminated Si nanocrystal diameter and narrow size distribution through photocatalyzed dissolution in a HF/HNO 3 acid mixture. Si particles were produced using the lateral etching of a Si wafer in a HF/EtOH/H 2 O bath followed by sonication in deaerated methanol. Initial suspensions exhibited broad photoluminescence in the red spectral region. Photoassisted etching was carried out by adding the HF/HNO 3 acid mixture to the suspension and exposing it to a 340 nm light. Photoluminescence and absorbance spectra, measured during dissolution, show the gradual particle size decrease as confirmed by the photoluminescence blue shift. The simultaneous narrowing of the photoluminescence spectral bandwidth suggests that the dissolution rate varies with the particle size. We show that the Si nanoparticle dissolution rate depends on the amount of light adsorbed by the particle and accounts for the etching rate variation with the particle size. Significant improvement in the PL quantum yield is observed during the acid treatment, suggesting improvement in the dangling bond passivation.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"ECS Meeting Abstracts","grobid_abstract_attachment_id":115910825},"translated_abstract":null,"internal_url":"https://www.academia.edu/120904382/Photo_Assisted_Tuning_of_Si_Nano_Crystal_Photoluminescence","translated_internal_url":"","created_at":"2024-06-12T01:15:55.117-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38560448,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115910825,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115910825/thumbnails/1.jpg","file_name":"ChoiJonghoon_Photoassisted_Tuning_of_Silicon_Nanocrystal_Photoluminescence.pdf","download_url":"https://www.academia.edu/attachments/115910825/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Photo_Assisted_Tuning_of_Si_Nano_Crystal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115910825/ChoiJonghoon_Photoassisted_Tuning_of_Silicon_Nanocrystal_Photoluminescence-libre.pdf?1718181097=\u0026response-content-disposition=attachment%3B+filename%3DPhoto_Assisted_Tuning_of_Si_Nano_Crystal.pdf\u0026Expires=1732780219\u0026Signature=ZTjNaCL4Lj91CPzrKbNSjs19Fj6ZL0O8sKROidQMr0wzq3D2mZwz81i5NCZ1-cOQbL5uUPpwOs3B4j0XIPtDb9AGWwpAkMvIyro-~Be~XC5VMq1dN0~JhZf7oqFWZy2SYRpkGuXDpqw2EUXzUX3BtAr~Ml3Kt30bennZI6NBRNIK921i~UHq-EJEQllrayi7jEKMohLZmBd3y5-4jYuMoCT1qulO83rivFdr6DiSUfP-QSRZ0R--NXIviQfIbMWUDJdtUu1PCPa0cLtK9xpNrjcthHEXhYOGK3oEpe-tlHF5V5hxKkMjusgKuTY5Ww6FJtnYPMf0ijUZgYVD3-5vmQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Photo_Assisted_Tuning_of_Si_Nano_Crystal_Photoluminescence","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":38560448,"first_name":"Nam","middle_initials":null,"last_name":"Wang","page_name":"NamWang","domain_name":"umcp","created_at":"2015-11-17T12:28:19.888-08:00","display_name":"Nam Wang","url":"https://umcp.academia.edu/NamWang"},"attachments":[{"id":115910825,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115910825/thumbnails/1.jpg","file_name":"ChoiJonghoon_Photoassisted_Tuning_of_Silicon_Nanocrystal_Photoluminescence.pdf","download_url":"https://www.academia.edu/attachments/115910825/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Photo_Assisted_Tuning_of_Si_Nano_Crystal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115910825/ChoiJonghoon_Photoassisted_Tuning_of_Silicon_Nanocrystal_Photoluminescence-libre.pdf?1718181097=\u0026response-content-disposition=attachment%3B+filename%3DPhoto_Assisted_Tuning_of_Si_Nano_Crystal.pdf\u0026Expires=1732780219\u0026Signature=ZTjNaCL4Lj91CPzrKbNSjs19Fj6ZL0O8sKROidQMr0wzq3D2mZwz81i5NCZ1-cOQbL5uUPpwOs3B4j0XIPtDb9AGWwpAkMvIyro-~Be~XC5VMq1dN0~JhZf7oqFWZy2SYRpkGuXDpqw2EUXzUX3BtAr~Ml3Kt30bennZI6NBRNIK921i~UHq-EJEQllrayi7jEKMohLZmBd3y5-4jYuMoCT1qulO83rivFdr6DiSUfP-QSRZ0R--NXIviQfIbMWUDJdtUu1PCPa0cLtK9xpNrjcthHEXhYOGK3oEpe-tlHF5V5hxKkMjusgKuTY5Ww6FJtnYPMf0ijUZgYVD3-5vmQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":511,"name":"Materials Science","url":"https://www.academia.edu/Documents/in/Materials_Science"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":17733,"name":"Nanotechnology","url":"https://www.academia.edu/Documents/in/Nanotechnology"},{"id":35267,"name":"Photoluminescence","url":"https://www.academia.edu/Documents/in/Photoluminescence"},{"id":44299,"name":"Optoelectronics","url":"https://www.academia.edu/Documents/in/Optoelectronics"},{"id":49651,"name":"Nano","url":"https://www.academia.edu/Documents/in/Nano"},{"id":743666,"name":"Langmuir","url":"https://www.academia.edu/Documents/in/Langmuir"},{"id":3604167,"name":"Meeting Abstracts","url":"https://www.academia.edu/Documents/in/Meeting_Abstracts"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120904381"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120904381/Microbial_fermentation_monitoring_using_near_infrared_spectroscopy"><img alt="Research paper thumbnail of Microbial fermentation monitoring using near-infrared spectroscopy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120904381/Microbial_fermentation_monitoring_using_near_infrared_spectroscopy">Microbial fermentation monitoring using near-infrared spectroscopy</a></div><div class="wp-workCard_item"><span>American biotechnology laboratory</span><span>, 1993</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120904381"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120904381"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120904381; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="106200941"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/106200941/Structure_Based_Engineering_of_Methionine_Residues_in_the_Catalytic_Cores_of_Alkaline_Amylase_from_Alkalimonas_amylolytica_for_Improved_Oxidative_Stability"><img alt="Research paper thumbnail of Structure-Based Engineering of Methionine Residues in the Catalytic Cores of Alkaline Amylase from Alkalimonas amylolytica for Improved Oxidative Stability" class="work-thumbnail" src="https://attachments.academia-assets.com/105459368/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/106200941/Structure_Based_Engineering_of_Methionine_Residues_in_the_Catalytic_Cores_of_Alkaline_Amylase_from_Alkalimonas_amylolytica_for_Improved_Oxidative_Stability">Structure-Based Engineering of Methionine Residues in the Catalytic Cores of Alkaline Amylase from Alkalimonas amylolytica for Improved Oxidative Stability</a></div><div class="wp-workCard_item"><span>Applied and Environmental Microbiology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This work aims to improve the oxidative stability of alkaline amylase from Alkalimonas amylolytic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This work aims to improve the oxidative stability of alkaline amylase from Alkalimonas amylolytica through structure-based site-directed mutagenesis. Based on an analysis of the tertiary structure, five methionines (Met 145, Met 214, Met 229, Met 247, and Met 317) were selected as the mutation sites and individually replaced with leucine. In the presence of 500 mM H 2 O 2 at 35°C for 5 h, the wild-type enzyme and the M145L, M214L, M229L, M247L, and M317L mutants retained 10%, 28%, 46%, 28%, 72%, and 43% of the original activity, respectively. Concomitantly, the alkaline stability, thermal stability, and catalytic efficiency of the M247L mutant were also improved. The pH stability of the mutants (M145L, M214L, M229L, and M317L) remained unchanged compared to that of the wild-type enzyme, while the stable pH range of the M247L mutant was extended from pH 7.0 to 11.0 for the wild type to pH 6.0 to 12.0 for the mutant. 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The pH stability of the mutants (M145L, M214L, M229L, and M317L) remained unchanged compared to that of the wild-type enzyme, while the stable pH range of the M247L mutant was extended from pH 7.0 to 11.0 for the wild type to pH 6.0 to 12.0 for the mutant. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99400233"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99400233/Effect_of_background_fluorophores_on_the_NADH_fluorescence_probe_signal"><img alt="Research paper thumbnail of Effect of background fluorophores on the NADH fluorescence probe signal" class="work-thumbnail" src="https://attachments.academia-assets.com/100541563/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99400233/Effect_of_background_fluorophores_on_the_NADH_fluorescence_probe_signal">Effect of background fluorophores on the NADH fluorescence probe signal</a></div><div class="wp-workCard_item"><span>Biotechnology Techniques</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Analysis of the errors caused by a drift in background fluorescence is performed for a fluorescen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Analysis of the errors caused by a drift in background fluorescence is performed for a fluorescence probe operated in a backscatter configuration. In some cases, significant errors can result if changes in background fluorophores during the course of fermentation are not accounted for. It is shown that the probe's sensitivity to background fluorophores must be considered to calibrate a fluorescence probe properly.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c4b90078da5ea3596d197be0a9f1ba93" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":100541563,"asset_id":99400233,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/100541563/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99400233"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99400233"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99400233; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=99400233]").text(description); $(".js-view-count[data-work-id=99400233]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 99400233; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='99400233']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 99400233, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c4b90078da5ea3596d197be0a9f1ba93" } } $('.js-work-strip[data-work-id=99400233]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":99400233,"title":"Effect of background fluorophores on the NADH fluorescence probe signal","translated_title":"","metadata":{"doi":"10.1007/BF02438655","volume":"5","abstract":"Analysis of the errors caused by a drift in background fluorescence is performed for a fluorescence probe operated in a backscatter configuration. In some cases, significant errors can result if changes in background fluorophores during the course of fermentation are not accounted for. It is shown that the probe's sensitivity to background fluorophores must be considered to calibrate a fluorescence probe properly.","publisher":"Springer Nature","page_numbers":"241-246","publication_date":{"day":null,"month":null,"year":1991,"errors":{}},"publication_name":"Biotechnology Techniques"},"translated_abstract":"Analysis of the errors caused by a drift in background fluorescence is performed for a fluorescence probe operated in a backscatter configuration. In some cases, significant errors can result if changes in background fluorophores during the course of fermentation are not accounted for. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="92433507"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/92433507/A_method_of_variables_selection_for_soft_sensor_bas_ed_on_distributed_mutual_information"><img alt="Research paper thumbnail of A method of variables selection for soft sensor bas ed on distributed mutual information" class="work-thumbnail" src="https://attachments.academia-assets.com/95443064/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/92433507/A_method_of_variables_selection_for_soft_sensor_bas_ed_on_distributed_mutual_information">A method of variables selection for soft sensor bas ed on distributed mutual information</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A method of distributed mutual information is propo sed for selecting secondary variables in a so...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A method of distributed mutual information is propo sed for selecting secondary variables in a soft sen sor. The mutual information between the predicted primary va riable and the secondary variables is obtained by e stimating the probability distribution of every secondary var iable and the predicted variable. This information indirectly reflects the linear or nonlinear correlations betwe en the predicted variable and the secondary variabl es. A threshold value is obtained by t-test approach as a criterion to judge the correlation of variables. Subsequentl y, the variables whose mutual information is greater than the thresh old value are further screened to be selected as th e relevant variables or to be discarded as weakly relevant var iables. Finally, a soft sensor model is built based on the support vector machine algorithm with the selected secondar y variables.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5e70e491d5ede9d9e6445f3538b79d6e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95443064,"asset_id":92433507,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95443064/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92433507"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92433507"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92433507; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92433507]").text(description); $(".js-view-count[data-work-id=92433507]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92433507; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92433507']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 92433507, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5e70e491d5ede9d9e6445f3538b79d6e" } } $('.js-work-strip[data-work-id=92433507]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92433507,"title":"A method of variables selection for soft sensor bas ed on distributed mutual information","translated_title":"","metadata":{"abstract":"A method of distributed mutual information is propo sed for selecting secondary variables in a soft sen sor. The mutual information between the predicted primary va riable and the secondary variables is obtained by e stimating the probability distribution of every secondary var iable and the predicted variable. This information indirectly reflects the linear or nonlinear correlations betwe en the predicted variable and the secondary variabl es. A threshold value is obtained by t-test approach as a criterion to judge the correlation of variables. Subsequentl y, the variables whose mutual information is greater than the thresh old value are further screened to be selected as th e relevant variables or to be discarded as weakly relevant var iables. Finally, a soft sensor model is built based on the support vector machine algorithm with the selected secondar y variables.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"A method of distributed mutual information is propo sed for selecting secondary variables in a soft sen sor. The mutual information between the predicted primary va riable and the secondary variables is obtained by e stimating the probability distribution of every secondary var iable and the predicted variable. This information indirectly reflects the linear or nonlinear correlations betwe en the predicted variable and the secondary variabl es. A threshold value is obtained by t-test approach as a criterion to judge the correlation of variables. Subsequentl y, the variables whose mutual information is greater than the thresh old value are further screened to be selected as th e relevant variables or to be discarded as weakly relevant var iables. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="92433506"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/92433506/Effect_of_Carbon_Chain_Length_Ionic_Strength_and_pH_on_the_In_Vitro_Release_Kinetics_of_Cationic_Drugs_from_Fatty_Acid_Loaded_Contact_Lenses"><img alt="Research paper thumbnail of Effect of Carbon Chain Length, Ionic Strength, and pH on the In Vitro Release Kinetics of Cationic Drugs from Fatty-Acid-Loaded Contact Lenses" class="work-thumbnail" src="https://attachments.academia-assets.com/95443062/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/92433506/Effect_of_Carbon_Chain_Length_Ionic_Strength_and_pH_on_the_In_Vitro_Release_Kinetics_of_Cationic_Drugs_from_Fatty_Acid_Loaded_Contact_Lenses">Effect of Carbon Chain Length, Ionic Strength, and pH on the In Vitro Release Kinetics of Cationic Drugs from Fatty-Acid-Loaded Contact Lenses</a></div><div class="wp-workCard_item"><span>Pharmaceutics</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This paper explores the use of fatty acids in silicone hydrogel contact lenses for extending the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This paper explores the use of fatty acids in silicone hydrogel contact lenses for extending the release duration of cationic drugs. Drug release kinetics was dependent on the carbon chain length of the fatty acid loaded in the lens, with 12-, 14- and 18-carbon chain length fatty acids increasing the uptake and the release duration of ketotifen fumarate (KTF) and tetracaine hydrochloride (THCL). Drug release kinetics from oleic acid-loaded lenses was evaluated in phosphate buffer saline (PBS) at different ionic strengths (I = 167, 500, 1665 mM); the release duration of KTF and THCL was decreased with increasing ionic strength of the release medium. Furthermore, the release of KTF and THCL in deionized water did not show a burst and was significantly slower compared to that in PBS. The release kinetics of KTF and THCL was significantly faster when the pH of the release medium was decreased from 7.4 towards 5.5 because of the decrease in the relative amounts of oleate anions in the le...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8891449d6c727ab7f149feea3f65e9e3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95443062,"asset_id":92433506,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95443062/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92433506"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92433506"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92433506; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92433506]").text(description); $(".js-view-count[data-work-id=92433506]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92433506; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92433506']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 92433506, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8891449d6c727ab7f149feea3f65e9e3" } } $('.js-work-strip[data-work-id=92433506]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92433506,"title":"Effect of Carbon Chain Length, Ionic Strength, and pH on the In Vitro Release Kinetics of Cationic Drugs from Fatty-Acid-Loaded Contact Lenses","translated_title":"","metadata":{"abstract":"This paper explores the use of fatty acids in silicone hydrogel contact lenses for extending the release duration of cationic drugs. Drug release kinetics was dependent on the carbon chain length of the fatty acid loaded in the lens, with 12-, 14- and 18-carbon chain length fatty acids increasing the uptake and the release duration of ketotifen fumarate (KTF) and tetracaine hydrochloride (THCL). Drug release kinetics from oleic acid-loaded lenses was evaluated in phosphate buffer saline (PBS) at different ionic strengths (I = 167, 500, 1665 mM); the release duration of KTF and THCL was decreased with increasing ionic strength of the release medium. Furthermore, the release of KTF and THCL in deionized water did not show a burst and was significantly slower compared to that in PBS. The release kinetics of KTF and THCL was significantly faster when the pH of the release medium was decreased from 7.4 towards 5.5 because of the decrease in the relative amounts of oleate anions in the le...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Pharmaceutics"},"translated_abstract":"This paper explores the use of fatty acids in silicone hydrogel contact lenses for extending the release duration of cationic drugs. Drug release kinetics was dependent on the carbon chain length of the fatty acid loaded in the lens, with 12-, 14- and 18-carbon chain length fatty acids increasing the uptake and the release duration of ketotifen fumarate (KTF) and tetracaine hydrochloride (THCL). Drug release kinetics from oleic acid-loaded lenses was evaluated in phosphate buffer saline (PBS) at different ionic strengths (I = 167, 500, 1665 mM); the release duration of KTF and THCL was decreased with increasing ionic strength of the release medium. Furthermore, the release of KTF and THCL in deionized water did not show a burst and was significantly slower compared to that in PBS. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="92433503"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/92433503/Isolation_and_Purification_of_Exosomes_in_Urine"><img alt="Research paper thumbnail of Isolation and Purification of Exosomes in Urine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/92433503/Isolation_and_Purification_of_Exosomes_in_Urine">Isolation and Purification of Exosomes in Urine</a></div><div class="wp-workCard_item"><span>Methods in Molecular Biology</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Exosomes represent an important and readily isolated subset of the urinary proteome that has the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Exosomes represent an important and readily isolated subset of the urinary proteome that has the potential to shed much insight on the health status of the kidney. Each segment of the nephron sheds exosomes into the urine. Exosomes are rich in potential biomarkers, especially membrane proteins such as transporters and receptors that may be up- or downregulated during disease states. Two differential centrifugation methods are available for simple purification of exosomes: one uses ultracentrifugation, and the other uses a nanomembrane concentrator. Validation methods include western blots of pan-exosome markers and segment-specific exosome markers, and negative staining electron microscopy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92433503"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92433503"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92433503; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92433503]").text(description); $(".js-view-count[data-work-id=92433503]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92433503; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92433503']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 92433503, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=92433503]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92433503,"title":"Isolation and Purification of Exosomes in Urine","translated_title":"","metadata":{"abstract":"Exosomes represent an important and readily isolated subset of the urinary proteome that has the potential to shed much insight on the health status of the kidney. Each segment of the nephron sheds exosomes into the urine. Exosomes are rich in potential biomarkers, especially membrane proteins such as transporters and receptors that may be up- or downregulated during disease states. Two differential centrifugation methods are available for simple purification of exosomes: one uses ultracentrifugation, and the other uses a nanomembrane concentrator. Validation methods include western blots of pan-exosome markers and segment-specific exosome markers, and negative staining electron microscopy.","publisher":"Humana Press","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Methods in Molecular Biology"},"translated_abstract":"Exosomes represent an important and readily isolated subset of the urinary proteome that has the potential to shed much insight on the health status of the kidney. Each segment of the nephron sheds exosomes into the urine. Exosomes are rich in potential biomarkers, especially membrane proteins such as transporters and receptors that may be up- or downregulated during disease states. Two differential centrifugation methods are available for simple purification of exosomes: one uses ultracentrifugation, and the other uses a nanomembrane concentrator. Validation methods include western blots of pan-exosome markers and segment-specific exosome markers, and negative staining electron microscopy.","internal_url":"https://www.academia.edu/92433503/Isolation_and_Purification_of_Exosomes_in_Urine","translated_internal_url":"","created_at":"2022-12-08T07:42:40.349-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38560448,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Isolation_and_Purification_of_Exosomes_in_Urine","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38560448,"first_name":"Nam","middle_initials":null,"last_name":"Wang","page_name":"NamWang","domain_name":"umcp","created_at":"2015-11-17T12:28:19.888-08:00","display_name":"Nam Wang","url":"https://umcp.academia.edu/NamWang"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":14076,"name":"Transmission Electron Microscopy","url":"https://www.academia.edu/Documents/in/Transmission_Electron_Microscopy"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting"},{"id":128132,"name":"Nanostructures","url":"https://www.academia.edu/Documents/in/Nanostructures"},{"id":165131,"name":"Exosomes","url":"https://www.academia.edu/Documents/in/Exosomes"},{"id":193464,"name":"Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis","url":"https://www.academia.edu/Documents/in/Sodium_Dodecyl_Sulfate-Polyacrylamide_Gel_Electrophoresis"},{"id":291643,"name":"Urinalysis","url":"https://www.academia.edu/Documents/in/Urinalysis"},{"id":457191,"name":"Analytical Ultracentrifugation","url":"https://www.academia.edu/Documents/in/Analytical_Ultracentrifugation"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"},{"id":836492,"name":"Exosome","url":"https://www.academia.edu/Documents/in/Exosome"},{"id":1035050,"name":"Proteome","url":"https://www.academia.edu/Documents/in/Proteome"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":2228703,"name":"Microvesicles","url":"https://www.academia.edu/Documents/in/Microvesicles"},{"id":2468093,"name":"Cell Membrane","url":"https://www.academia.edu/Documents/in/Cell_Membrane"}],"urls":[{"id":26800749,"url":"http://link.springer.com/content/pdf/10.1007/978-1-60761-711-2_6.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="92433502"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/92433502/Controlled_Drug_Release_from_an_Ocular_Implant_An_Evaluation_Using_Dynamic_Three_Dimensional_Magnetic_Resonance_Imaging"><img alt="Research paper thumbnail of Controlled Drug Release from an Ocular Implant: An Evaluation Using Dynamic Three-Dimensional Magnetic Resonance Imaging" class="work-thumbnail" src="https://attachments.academia-assets.com/95443107/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/92433502/Controlled_Drug_Release_from_an_Ocular_Implant_An_Evaluation_Using_Dynamic_Three_Dimensional_Magnetic_Resonance_Imaging">Controlled Drug Release from an Ocular Implant: An Evaluation Using Dynamic Three-Dimensional Magnetic Resonance Imaging</a></div><div class="wp-workCard_item"><span>Investigative Opthalmology &amp; Visual Science</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ea91e3d37e422b9e5593bfb72bc0c3c3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95443107,"asset_id":92433502,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95443107/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92433502"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92433502"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92433502; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92433502]").text(description); $(".js-view-count[data-work-id=92433502]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92433502; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92433502']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 92433502, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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The ability of an episcleral implant at the equator of the eye to deliver drugs to the posterior segment was evaluated, using a sustained-release implant containing gadolinium-DTPA (Gd-DTPA). The movement of this drug surrogate was assessed with magnetic resonance imaging (MRI) in the rabbit eye. The results were compared with a similar implant placed in the vitreous cavity through a scleral incision at the equator. METHODS. Polymer-based implants releasing Gd-DTPA were manufactured and placed in the subconjunctival space on the episclera or in the vitreous cavity in live rabbit eyes (in vivo) and in freshly enucleated eyes (ex vivo). Release rates of implants in vitro were also determined. Dynamic three-dimensional MRI was performed using a 4.7-Tesla MRI system for 8 hours. MR images were developed and analyzed on computer. RESULTS. Episcleral implants in vivo delivered a mean total of 2.7 g Gd-DTPA into the vitreous, representing only 0.12% of the total amount of compound released from the implant in vitro. No Gd-DTPA was detected in the posterior segment of the eye. Ex vivo, the Gd-DTPA concentration in the vitreous was 30 times higher. In vivo eyes with intravitreal implants placed at the equator delivered Gd-DTPA throughout the vitreous cavity and posterior segment. Compartmental analysis of the ocular drug distribution from an episcleral implant showed that the elimination rate constant of Gd-DTPA from the subconjunctival space into the episcleral veins and conjunctival lymphatics was 3-log units higher than the transport rate constant for Gd-DTPA movement into the vitreous. CONCLUSIONS. In vivo, episcleral implants at the equator of the eye did not deliver a significant amount of Gd-DTPA into the vitreous, and no compound was identified in the posterior segment. A 30-fold increase in vitreous Gd-DTPA concentration occurred in the enucleated eyes, suggesting that there are significant barriers to the movement of drugs from the episcleral space into the vitreous in vivo. Dynamic three-dimensional MRI using Gd-DTPA, and possibly other contrast agents, may be useful in understanding the spatial relationships of ocular drug distribution and clearance mechanisms in the eye.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Investigative Opthalmology \u0026amp; Visual Science","grobid_abstract_attachment_id":95443107},"translated_abstract":null,"internal_url":"https://www.academia.edu/92433502/Controlled_Drug_Release_from_an_Ocular_Implant_An_Evaluation_Using_Dynamic_Three_Dimensional_Magnetic_Resonance_Imaging","translated_internal_url":"","created_at":"2022-12-08T07:42:40.166-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38560448,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":95443107,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/95443107/thumbnails/1.jpg","file_name":"z7g00804002722.pdf","download_url":"https://www.academia.edu/attachments/95443107/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Controlled_Drug_Release_from_an_Ocular_I.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/95443107/z7g00804002722-libre.pdf?1670514476=\u0026response-content-disposition=attachment%3B+filename%3DControlled_Drug_Release_from_an_Ocular_I.pdf\u0026Expires=1732780219\u0026Signature=DrmPbhw8H57lIR~TSoq0DdMNJnqPNTJUMMTfNGQE57lSsH9t3Y~UO85-7BwLmARlKk8rFkyC60nPafq3AT4yR5Wh2GHTUXR1FtwpzRVxFyj5mNBj63bNZT0YI93Hcrkx82xUrJz50exjWAs-eCf5dcrRam~BV58WKyvDyWVkVyt27sFtT-0xq4ytxyy~d83Zcn96bxOU8CG0Zvm-VCcRVlzYShoQ3sPEXcP-0QwlcVNqWrR2iRkzoj7kzihWoU6te3MptTsDHXNa2rNUUXa0zVDKHwyqdjiZMYTEa6wZFBLz7wTCdD2F5ppi9xyZLgSpxx4W5gO92CcF~2f5DqX2KQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Controlled_Drug_Release_from_an_Ocular_Implant_An_Evaluation_Using_Dynamic_Three_Dimensional_Magnetic_Resonance_Imaging","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":38560448,"first_name":"Nam","middle_initials":null,"last_name":"Wang","page_name":"NamWang","domain_name":"umcp","created_at":"2015-11-17T12:28:19.888-08:00","display_name":"Nam Wang","url":"https://umcp.academia.edu/NamWang"},"attachments":[{"id":95443107,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/95443107/thumbnails/1.jpg","file_name":"z7g00804002722.pdf","download_url":"https://www.academia.edu/attachments/95443107/download_file?st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Controlled_Drug_Release_from_an_Ocular_I.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/95443107/z7g00804002722-libre.pdf?1670514476=\u0026response-content-disposition=attachment%3B+filename%3DControlled_Drug_Release_from_an_Ocular_I.pdf\u0026Expires=1732780219\u0026Signature=DrmPbhw8H57lIR~TSoq0DdMNJnqPNTJUMMTfNGQE57lSsH9t3Y~UO85-7BwLmARlKk8rFkyC60nPafq3AT4yR5Wh2GHTUXR1FtwpzRVxFyj5mNBj63bNZT0YI93Hcrkx82xUrJz50exjWAs-eCf5dcrRam~BV58WKyvDyWVkVyt27sFtT-0xq4ytxyy~d83Zcn96bxOU8CG0Zvm-VCcRVlzYShoQ3sPEXcP-0QwlcVNqWrR2iRkzoj7kzihWoU6te3MptTsDHXNa2rNUUXa0zVDKHwyqdjiZMYTEa6wZFBLz7wTCdD2F5ppi9xyZLgSpxx4W5gO92CcF~2f5DqX2KQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6200,"name":"Magnetic 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})(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "88943e055ff4cf29d427dcab2046fc31" } } $('.js-work-strip[data-work-id=92433501]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92433501,"title":"Assessment of Subconjunctival and Intrascleral Drug Delivery to the Posterior Segment Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging","translated_title":"","metadata":{"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","ai_title_tag":"Intrascleral Gd-DTPA Delivery to the Eye Posterior Segment","grobid_abstract":"PURPOSE. Sustained-release intravitreal drug implants for posterior segment diseases are associated with significant complications. As an alternative, subconjunctival infusions of drug to the episclera of the back of the eye have been performed, but results in clinical trials for macular diseases showed mixed results. To improve understanding of transscleral drug delivery to the posterior segment, the distribution and clearance of gadolinium-diethylenetriaminopentaacetic acid (Gd-DTPA) infused in the subconjunctival or intrascleral space was investigated by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). METHODS. In anesthetized rabbits, catheters were placed anteriorly in the subconjunctival or intrascleral space and infused with Gd-DTPA at 1 and 10 L/min. Distribution and clearance of Gd-DTPA were measured using DCE-MRI. Histologic examination was performed to assess ocular toxicity of the delivery system. RESULTS. Subconjunctival infusions failed to produce detectable levels of Gd-DTPA in the back of the eye. In contrast, intrascleral infusions expanded the suprachoroidal layer and delivered Gd-DTPA to the posterior segment. Suprachoroidal clearance of Gd-DTPA followed first-order kinetics with an average half-life of 5.4 and 11.8 minutes after intrascleral infusions at 1 and 10 L/min, respectively. Histologic examination demonstrated expansion of the tissues in the suprachoroidal space that normalized after infusion termination. CONCLUSIONS. An intrascleral infusion was successful in transporting Gd-DTPA to the posterior segment from an anterior infusion site with limited anterior segment exposure. The suprachoroidal space appears to be an expandible conduit for drug transport to the posterior segment. Further studies are indicated to explore the feasibility of clinical applications.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Investigative Opthalmology \u0026amp; Visual 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href="https://www.academia.edu/92433382/Study_of_Ocular_Transport_of_Drugs_Released_from_an_Intravitreal_Implant_Using_Magnetic_Resonance_Imaging"><img alt="Research paper thumbnail of Study of Ocular Transport of Drugs Released from an Intravitreal Implant Using Magnetic Resonance Imaging" class="work-thumbnail" src="https://attachments.academia-assets.com/95443095/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/92433382/Study_of_Ocular_Transport_of_Drugs_Released_from_an_Intravitreal_Implant_Using_Magnetic_Resonance_Imaging">Study of Ocular Transport of Drugs Released from an Intravitreal Implant Using Magnetic Resonance Imaging</a></div><div class="wp-workCard_item"><span>Annals of Biomedical Engineering</span><span>, 2005</span></div><div class="wp-workCard_item 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{"id":92433382,"title":"Study of Ocular Transport of Drugs Released from an Intravitreal Implant Using Magnetic Resonance Imaging","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","grobid_abstract":"Ensuring optimum delivery of therapeutic agents in the eye requires detailed information about the transport mechanisms and elimination pathways available. This knowledge can guide the development of new drug delivery devices. In this study, we investigated the movement of a drug surrogate, Gd-DTPA (Magnevist ) released from a polymer-based implant in rabbit vitreous using T 1-weighted magnetic resonance imaging (MRI). Intensity values in the MRI data were converted to concentration by comparison with calibration samples. Concentration profiles approaching pseudosteady state showed gradients from the implant toward the retinal surface, suggesting that diffusion was occurring into the retinal-choroidal-scleral (RCS) membrane. Gd-DTPA concentration varied from high values near the implant to lower values distal to the implant. Such regional concentration differences throughout the vitreous may have clinical significance when attempting to treat ubiquitous eye diseases using a single positional implant. We developed a finite element mathematical model of the rabbit eye and compared the MRI experimental concentration data with simulation concentration profiles. The model utilized a diffusion coefficient of Gd-DTPA in the vitreous of 2.8 × 10 −6 cm 2 s −1 and yielded a diffusion coefficient for Gd-DTPA through the simulated composite posterior membrane (representing the retina-choroidsclera membrane) of 6.0 × 10 −8 cm 2 s −1. Since the model membrane was 0.03-cm thick, this resulted in an effective membrane permeability of 2.0 × 10 −6 cm s −1. Convective movement of Gd-DTPA was shown to have minimal effect on the concentration profiles since the Peclet number was 0.09 for this system.","publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Annals of Biomedical 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