CINXE.COM

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class="button-more text-center" href="/">WEITER</a></p> </div> </div> </div> </section> </div> </div> </div> </div> <div id="clp-whole-header-top" class="container-fluid"> <div class="site-branding-menu-wrapper .row"> <div class="col-sm-4 site-branding"> <div class="clp-header-top_left"> <div class="region region-clp-header-top-left"> <section id="block-clplogo" class="block block-block-content block-block-contentbb568d43-f6bc-492d-b5aa-ecead699fbce clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><p><img alt="Alnylam® Pharmaceuticals Logo" src="/themes/custom/alnylam/logo.svg" /></p> </div> </section> </div> </div> </div> <div class="col-sm-8 menu"> <div class="row secondary-menu"> <div class="clp-header-right-top"> <div class="region region-clp-header-right-top"> <section id="block-secondarymenuclpluxembourggerman" class="block block-block-content block-block-contentcd008d7d-b686-4b7d-9b49-fbfb8f6d98b6 clearfix"> <div 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style="display:none; background:#fff;"> <h2 class="text-align-center">SIE WERDEN WEITERGELEITET</h2> <p class="text-align-center">Sie sind im Begriff, www.alnylam.lu zu verlassen und zu unserer globalen Website (www.alnylam.com) zu gehen, die in englischer Sprache verfasst ist.</p> <p class="text-align-center"><a class="button-more text-center" href="/careers/">WEITER</a></p> </div> </div> </div> </section> <section id="block-language-4" class="block block-block-content block-block-content5a7dc698-6efe-4c02-a3cd-adb2377d4faf clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div class="language block" id="language-switcher-icon">language<i class="fas fa-angle-down"></i></div> </div> </section> </div> </div> </div> <div class="row ext-cta"> <div class="clp-header-right-bottom"> <div class="region region-clp-header-right-bottom"> <section id="block-clpheaderblockforluxembourggerman" class="block block-block-content block-block-content6a8b8ce7-c528-4d92-af04-6e3de5f33c0b clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><p><a data-colorbox-inline=".cta-header-luxembourg-german">Besuchen Sie die globale Website von Alnylam (in englischer Sprache) ›</a></p> <div class="popup-content" style="display:none; background:#fff; padding:opx;"> <div class="cta-header-luxembourg-german popup-content" style="display:none; background:#fff;"> <h2 class="text-align-center">SIE WERDEN WEITERGELEITET</h2> <p class="text-center text-align-center">Sie sind im Begriff, www.alnylam.lu zu verlassen und zu unserer globalen Website (www.alnylam.com) zu gehen, die in englischer Sprache verfasst ist.</p> <p class="text-align-center"><a class="button-more text-center" href="/">WEITER</a></p> </div> </div> </div> </section> </div> </div> </div> <div class="clp-language-switcher-block-wrapper"> <div class="clp-language-switcher-block"> <div class="region 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class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Österreich</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-austria">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--969 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Belgien</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-belgium-dutch">Nederlands</a></div> <div class="field--item"><a href="/alnylam-belgium-french">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--970 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Brasilien</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.com.br/">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--971 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Kanada</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.ca/fr">Français</a></div> <div class="field--item"><a href="https://www.alnylam.ca/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--972 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Tschechien</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-czech-republic">Čeština</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--973 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Dänemark</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-denmark">Dansk</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--974 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Frankreich</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.fr/">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--975 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Deutschland</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.de/">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--976 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Irland</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-ireland">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--977 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Italien</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.it/">Italiano</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--978 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Japan</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.jp/">Japanese</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--979 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Luxemburg</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-luxembourg-french">Français</a></div> <div class="field--item"><a href="/alnylam-luxembourg-german">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--980 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Niederlande</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-netherlands">Nederlands</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--981 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Portugal</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-portugal">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--982 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Spanien</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-espana">Español</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--983 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Schweden</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-sverige">Svenska</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--984 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Schweiz</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-switzerland-french">Français</a></div> <div class="field--item"><a href="/alnylam-switzerland-german">Deutsch</a></div> <div class="field--item"><a href="/alnylam-switzerland-italian">Italiano</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--985 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Taiwan</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-taiwan">Traditional Chinese</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--986 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Königreich Großbritannien</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-uk">English</a></div> </div> </span> </div> </div> </div> </div> </section> </div> </div> </div> </div> </div> </div> </header> <div id="maindiv" class="container-fluid"> <main id="midcontent-area" class="column main-content"> <div id="content"> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <article data-history-node-id="695" role="article" about="/alnylam-luxembourg-german" class="clp full clearfix"> <div class="content"> <div class="field field--name-field-add-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--banner-with-text paragraph-id--1409 paragraph--view-mode--default"> <div class="paragraph paragraph--type--banner-with-text paragraph-id--1409 paragraph--view-mode--default"> <div id="simple-banner-with-text-wrapper" style="background: url(/sites/default/files/2022-04/header_slider_belgium_french.jpg); background-size: cover; background-repeat: no-repeat;"> <div class="text-wrapper" style="width:1130px;margin:auto;"> <div class="upper-text"> <h2>Denen, die sagen “unmöglich, nicht machbar, unrealistisch”, erwidern wir:</h2> <h1>Diese Herausforderung Nehmen Wir An</h1> <p>Wir entwickeln momentan eine neue Medikamentenklasse namens RNAi Therapeutics, von der wir erwarten, dass sie das Leben von Menschen mit seltenen Krankheiten von Grund auf verändern kann.</p> </div> </div> </div> <div class="mobile-upper-text"> <h2>Denen, die sagen “unmöglich, nicht machbar, unrealistisch”, erwidern wir:</h2> <h1>Diese Herausforderung Nehmen Wir An</h1> <p>Wir entwickeln momentan eine neue Medikamentenklasse namens RNAi Therapeutics, von der wir erwarten, dass sie das Leben von Menschen mit seltenen Krankheiten von Grund auf verändern kann.</p> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-banner-overlay paragraph-id--1411 paragraph--view-mode--default"> <div id="clp-banner-overlay"> <div class="banner-text-wrapper" style="width:1130px; margin:auto;"> <div class="text-box"> <section> <h1 class="text-align-center"><strong>AN DER SPITZE DES WANDELS</strong></h1> <p class="text-align-center">Das Unternehmen Alnylam ist führend bei der Umsetzung der RNA-Interferenz (RNAi) in eine neue Medikamentenklasse für Patienten mit eingeschränkten oder unzureichenden Behandlungsmöglichkeiten. RNAi Therapeutics basieren auf wissenschaftlichen Erkenntnissen, die mit dem Nobelpreis ausgezeichnet wurden. Sie bieten einen Ansatz zur Behandlung zahlreicher schwerer Krankheiten, die Patienten stark belasten.</p> <p class="text-align-center">Alnylam, das im Jahr 2002 gegründet wurde, verfolgt eine kühne Vision: Wir verwandeln wissenschaftliches Potenzial in reale Therapien – mit einer robusten Forschungsplattform und zahlreichen Prüfmedikamenten in der Entwicklung, darunter fünf Produktkandidaten, die sich in den letzten Untersuchungsphasen befinden, und vier Produkte, die in den USA und in der EU zugelassen sind.</p> </section> <div class="counter-box"> <h3 class="text-center"> </h3> <div class="row"> <div class="col-sm-2"> <h1 class="text-align-center">><span>1k</span></h1> <p class="count-text text-align-center">Mitarbeiter</p> </div> <div class="col-sm-2"> <h1 class="text-align-center"><span>19</span></h1> <p class="count-text text-align-center">Staaten</p> </div> <div class="col-sm-2"> <h1 class="text-align-center"><span>11</span></h1> <p class="count-text text-align-center">Programme in der klinischen Entwicklung</p> </div> <div class="col-sm-2"> <h1 class="text-align-center"><span>4</span></h1> <p class="count-text text-align-center">Zugelassene Produkte</p> </div> <div class="col-sm-2"> <h1 class="text-align-center">><span>35</span></h1> <p class="count-text text-align-center">Klinische Studien</p> </div> <div class="col-sm-2"> <h1 class="text-align-center">><span>8</span></h1> <p class="count-text text-align-center">Jahre längste Verabreichungsdauer</p> </div> </div> <p class="text-center margin-top-24px"><em>mit Stand vom Juni 2022</em></p> </div> </div> </div> <div class=" popup-content" style="display:none; background:#fff;"> <div class="field field--name-field-pop-up-field field--type-entity-reference-revisions field--label-hidden field--item"> <div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-full-bleed-bg paragraph-id--1413 paragraph--view-mode--default"> <div class="paragraph paragraph--type--clp-full-bleed-bg paragraph-id--1413 paragraph--view-mode--default"> <div id="clp-full-bleed-bg" style="background: url(/sites/default/files/2022-01/cta_rnai_7.jpg); background-size: cover; background-repeat: no-repeat;"> <div class="text-wrapper" style="width:900px;margin:auto;"> <h1 class="text-align-center"><strong>RNAi: EINE BIOLOGISCHE REVOLUTION AUF GRUNDLAGE VON FORSCHUNGSARBEITEN, DIE MIT DEM NOBELPREIS AUSGEZEICHNET WURDEN</strong></h1> <p class="text-align-center">Die RNA-Interferenz (RNAi) ist ein Durchbruch bei unserem Wissen darüber, wie Gene in Zellen reguliert werden. Zudem stellt sie einen ganz neuartigen Ansatz bei der Entdeckung und Entwicklung von Medikamenten dar. 2006 ging der Nobelpreis für Physiologie und Medizin an Craig Mello und Andrew Fire. Damit wurde die Bedeutung der RNAi als wichtige wissenschaftliche Entdeckung anerkannt.</p> <p class="text-align-center"><a data-colorbox-inline=".Clp-Full-Bleed-BG-luxembourg-german">Weitere Informationen ›</a></p> </div> <div class="Clp-Full-Bleed-BG-luxembourg-german popup-content" style="display:none; background:#fff; overflow:hidden;"> <div class="field field--name-field-pop-up-content field--type-entity-reference-revisions field--label-hidden field--item"> <div> <h2 class="text-center">SIE WERDEN WEITERGELEITET</h2> <h4>Sie sind im Begriff, www.alnylam.lu zu verlassen und zu unserer globalen Website (www.alnylam.com) zu gehen, die in englischer Sprache verfasst ist.</h4> <p class="text-center"> <a class="button-more" href="/our-science/the-science-of-rnai" target= "_blank">WEITER</a> </p> </div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-html-background paragraph-id--1415 paragraph--view-mode--default"> <div id="clp-html-content-background" style="background-color:#f8f8f8;"> <div class="content-wrapper" style="width:1130px; margin:auto; "> <div class="clp-html-background-desc"> <h2 class="text-align-center"><strong>UNSER FOKUS</strong></h2> <p class="text-align-center">Der Schwerpunkt unserer Forschungsarbeiten im Bereich der RNAi-Therapeutika liegt bei Krankheiten mit hohem ungedecktem medizinischem Bedarf, die in 4 strategische Therapiebereiche (STArs strategische therapeutische Bereiche) fallen: genetische Medikamente, Herz- und Stoffwechselkrankheiten, Infektionskrankheiten und Erkrankungen des zentralen Nervensystems (ZNS) sowie Augenerkrankungen.</p> <p class="text-align-center"> </p> <p class="text-align-center">Unsere zugelassene Produkte für Patienten in der EU werden bei der Behandlung von hereditärer und Transthyretin (TTR)-Amyloidose, akute hepatische Porphyrien (AHP) und primitive Hyperoxalurie (PH)angewendet. Unsere therapeutischen Produktkandidaten in späten Entwicklungsphasen (Phase 2 bis Phase 3) richten sich vor allem an der Behandlung von hereditärer TTR-Amyloidose (hATTR), Hämophilie und Blutungserkrankungen, Hypercholesterinämie und komplementvermittelten Erkrankungen.</p> </div> <div class=" popup-content" style="display:none; background:#fff; overflow:hidden;"> <div class="field field--name-field-html-pop-up field--type-entity-reference-revisions field--label-hidden field--item"> <div> </div> </div> </div> </div> <div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-left-img-text paragraph-id--1417 paragraph--view-mode--default"> <div id="clp-left-img-text"> <div class="img-text-wrapper" style="width:1130px; margin:auto;"> <div class="img-box"> <div class="field field--name-field-upload-image field--type-image field--label-hidden field--item"> <img src="/sites/default/files/2023-05/join_our_team_clps_tptwa_5_0.png" width="751" height="435" alt="join_our_team" loading="lazy" typeof="foaf:Image" class="img-responsive" /> </div> </div> <div class="text-box"> <h2><strong>WERDEN SIE MITGLIED UNSERES TEAMS</strong></h2> <p>Wir verfolgen das Ziel, eine gewerbliche Organisation zu werden, die Patienten unabhängig Medikamente liefern kann. Dazu suchen wir Personen mit vielfältigen Kenntnissen, Erfahrungen und Werdegängen, um ein Team von Weltklasse aufzubauen. 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