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href="https://www.academia.edu/Documents/in/Apoptosis">Apoptosis</a>, <script data-card-contents-for-ri="24731" type="text/json">{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="38831" href="https://www.academia.edu/Documents/in/Signal_Transduction">Signal Transduction</a>, <script data-card-contents-for-ri="38831" type="text/json">{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="84760" href="https://www.academia.edu/Documents/in/Mice">Mice</a><script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=10610","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: 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Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=10610","nofollow":false},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=10610","nofollow":false},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=10610","nofollow":false},{"id":106169,"name":"Oncogene","url":"https://www.academia.edu/Documents/in/Oncogene?f_ri=10610"},{"id":121665,"name":"DNA methylation","url":"https://www.academia.edu/Documents/in/DNA_methylation?f_ri=10610"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=10610"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation?f_ri=10610"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_61610560" data-work_id="61610560" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/61610560/High_nuclear_MSK1_is_associated_with_longer_survival_in_breast_cancer_patients">High nuclear MSK1 is associated with longer survival in breast cancer patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Mitogen- and stress-activated kinases (MSKs) are important substrates of the mitogen-activated protein kinase (MAPK)-activated protein kinase family. MSK1 and MSK2 are both nuclear serine/threonine protein kinases, with MSK1 being... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61610560" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Mitogen- and stress-activated kinases (MSKs) are important substrates of the mitogen-activated protein kinase (MAPK)-activated protein kinase family. MSK1 and MSK2 are both nuclear serine/threonine protein kinases, with MSK1 being suggested to potentially play a role in breast cancer cell proliferation, cell cycle progression, cell migration, invasion and tumour growth. The aim of the current study was to assess MSK1 protein expression in breast cancer tumour specimens, evaluating its prognostic significance. A large cohort of 1902 early stage invasive breast cancer patients was used to explore the expression of MSK1. Protein expression was examined using standard immunohistochemistry on tissue microarrays. Low MSK1 protein expression was associated with younger age (P = 0.004), higher tumour grade (P &lt; 0.001), higher Nottingham Prognostic Index scores (P = 0.007), negative ER (P &lt; 0.001) and PR (P &lt; 0.001) status, and with triple-negative (P &lt; 0.001) and basal-like (P &...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61610560" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="22b2483fe61e7a1a4b1ab11c7196eaeb" rel="nofollow" data-download="{"attachment_id":74590379,"asset_id":61610560,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74590379/download_file?st=MTczMjgwMjA3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="58750969" href="https://independent.academia.edu/StewartMartin6">Stewart Martin</a><script data-card-contents-for-user="58750969" type="text/json">{"id":58750969,"first_name":"Stewart","last_name":"Martin","domain_name":"independent","page_name":"StewartMartin6","display_name":"Stewart Martin","profile_url":"https://independent.academia.edu/StewartMartin6?f_ri=10610","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_61610560 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61610560"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61610560, container: ".js-paper-rank-work_61610560", }); 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$(".js-view-count[data-work-id=61610560]").text(description); $(".js-view-count-work_61610560").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_61610560").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="61610560"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12071" href="https://www.academia.edu/Documents/in/Immunohistochemistry">Immunohistochemistry</a>, <script data-card-contents-for-ri="12071" type="text/json">{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="289271" href="https://www.academia.edu/Documents/in/Aged">Aged</a>, <script data-card-contents-for-ri="289271" type="text/json">{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="317801" href="https://www.academia.edu/Documents/in/Cell_nucleus">Cell nucleus</a><script data-card-contents-for-ri="317801" type="text/json">{"id":317801,"name":"Cell nucleus","url":"https://www.academia.edu/Documents/in/Cell_nucleus?f_ri=10610","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=61610560]'), work: {"id":61610560,"title":"High nuclear MSK1 is associated with longer survival in breast cancer patients","created_at":"2021-11-12T11:45:47.799-08:00","url":"https://www.academia.edu/61610560/High_nuclear_MSK1_is_associated_with_longer_survival_in_breast_cancer_patients?f_ri=10610","dom_id":"work_61610560","summary":"Mitogen- and stress-activated kinases (MSKs) are important substrates of the mitogen-activated protein kinase (MAPK)-activated protein kinase family. MSK1 and MSK2 are both nuclear serine/threonine protein kinases, with MSK1 being suggested to potentially play a role in breast cancer cell proliferation, cell cycle progression, cell migration, invasion and tumour growth. The aim of the current study was to assess MSK1 protein expression in breast cancer tumour specimens, evaluating its prognostic significance. A large cohort of 1902 early stage invasive breast cancer patients was used to explore the expression of MSK1. Protein expression was examined using standard immunohistochemistry on tissue microarrays. Low MSK1 protein expression was associated with younger age (P = 0.004), higher tumour grade (P \u0026lt; 0.001), higher Nottingham Prognostic Index scores (P = 0.007), negative ER (P \u0026lt; 0.001) and PR (P \u0026lt; 0.001) status, and with triple-negative (P \u0026lt; 0.001) and basal-like (P \u0026...","downloadable_attachments":[{"id":74590379,"asset_id":61610560,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":58750969,"first_name":"Stewart","last_name":"Martin","domain_name":"independent","page_name":"StewartMartin6","display_name":"Stewart Martin","profile_url":"https://independent.academia.edu/StewartMartin6?f_ri=10610","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=10610","nofollow":false},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=10610","nofollow":false},{"id":317801,"name":"Cell nucleus","url":"https://www.academia.edu/Documents/in/Cell_nucleus?f_ri=10610","nofollow":false},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=10610"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=10610"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms?f_ri=10610"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11958275" data-work_id="11958275" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11958275/Violence_and_Resistance_Beyond_P%C3%B3lemos_Foucault_and_Derrida_Between_Power_and_Unpower">Violence and Resistance Beyond Pólemos: Foucault and Derrida Between Power and Unpower</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">“Power is war, the continuation of war by other means”: Foucault’s reversal of Clausewitz’s formula has become a staple of critical theory — but it remains highly problematic on a conceptual level. Elaborated during Foucault’s 1976... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11958275" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">“Power is war, the continuation of war by other means”: Foucault’s reversal of Clausewitz’s formula has become a staple of critical theory — but it remains highly problematic on a conceptual level. Elaborated during Foucault’s 1976 lectures (“Society Must Be Defended”), this work-hypothesis theorises “basic warfare” [la guerre fondamentale] as the teleological horizon of socio-political relations. Following Boulainvilliers, Foucault champions this polemological approach, conceived as a purely descriptive discourse on “real” politics and war, against the philosophico-juridical conceptuality attached to liberal society (Hobbes’s Leviathan being here the prime example). <br />However, in doing so, Foucault did not interrogate the conceptual validity of notions such as power and war, therefore interlinking them without questioning their ontological status. This problematic conflation was partly rectified in 1982, as Foucault proposed a more dynamic definition of power relations: “actions over potential actions”. <br />I argue, somewhat polemically, that Foucault’s hermeneutics of power still involves a teleological violence, dependent on a polemological representation of human relations as essentially instrumental: this resembles what Derrida names, in “Heidegger’s Ear”, an “anthropolemology”. However, I show that all conceptualisation of power implies its self-deconstruction. This self-deconstructive (or autoimmune) structure supposes an archi-originary unpower prior to power: power presupposes an excess within power, an excessive force, another violence making it both possible and impossible. There is something within power located “beyond the power principle” (Derrida). This (self-)excess signifies a limitless resistantiality co-extensive with power-relationality. It also allows the reversal of pólemos into its opposite, as unpower opens politics and warfare to the messianic call of a pre-political, pre-ontological disruption: the archi-originary force of différance. This force, unconditional, challenges Foucault’s conceptualisations of power, suggesting an originary performativity located before or beyond hermeneutics of power-knowledge, disrupting theoreticity as well as empiricity by pointing to their ontological complicity.<br />The bulk of this essay is dedicated to sketching the theoretical implications of this deconstructive reading of Foucault with respect to the methodology and conceptuality of political science and social theory.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11958275" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="15788d3d8bb8c7c89be2736ccc1c6875" rel="nofollow" data-download="{"attachment_id":63286010,"asset_id":11958275,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/63286010/download_file?st=MTczMjgwMjA3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="2357791" href="https://uai.academia.edu/T_C_Mercier">Thomas Clément MERCIER</a><script data-card-contents-for-user="2357791" type="text/json">{"id":2357791,"first_name":"Thomas Clément","last_name":"MERCIER","domain_name":"uai","page_name":"T_C_Mercier","display_name":"Thomas Clément MERCIER","profile_url":"https://uai.academia.edu/T_C_Mercier?f_ri=10610","photo":"https://0.academia-photos.com/2357791/743316/55133078/s65_thomas_cl_ment.mercier.jpg"}</script></span></span></li><li class="js-paper-rank-work_11958275 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11958275"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11958275, container: ".js-paper-rank-work_11958275", }); 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$(".js-view-count[data-work-id=11958275]").text(description); $(".js-view-count-work_11958275").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11958275").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11958275"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">257</a>  </div><span class="InlineList-item-text u-textTruncate u-pl11x"><a class="InlineList-item-text" data-has-card-for-ri="8" href="https://www.academia.edu/Documents/in/Critical_Theory">Critical Theory</a>, <script data-card-contents-for-ri="8" type="text/json">{"id":8,"name":"Critical Theory","url":"https://www.academia.edu/Documents/in/Critical_Theory?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="94" href="https://www.academia.edu/Documents/in/Discourse_Analysis">Discourse Analysis</a>, <script data-card-contents-for-ri="94" type="text/json">{"id":94,"name":"Discourse Analysis","url":"https://www.academia.edu/Documents/in/Discourse_Analysis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="184" href="https://www.academia.edu/Documents/in/Sociology">Sociology</a>, <script data-card-contents-for-ri="184" type="text/json">{"id":184,"name":"Sociology","url":"https://www.academia.edu/Documents/in/Sociology?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="188" href="https://www.academia.edu/Documents/in/Cultural_Studies">Cultural Studies</a><script data-card-contents-for-ri="188" type="text/json">{"id":188,"name":"Cultural Studies","url":"https://www.academia.edu/Documents/in/Cultural_Studies?f_ri=10610","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11958275]'), work: {"id":11958275,"title":"Violence and Resistance Beyond Pólemos: Foucault and Derrida Between Power and Unpower","created_at":"2015-04-15T07:32:39.552-07:00","url":"https://www.academia.edu/11958275/Violence_and_Resistance_Beyond_P%C3%B3lemos_Foucault_and_Derrida_Between_Power_and_Unpower?f_ri=10610","dom_id":"work_11958275","summary":"“Power is war, the continuation of war by other means”: Foucault’s reversal of Clausewitz’s formula has become a staple of critical theory — but it remains highly problematic on a conceptual level. Elaborated during Foucault’s 1976 lectures (“Society Must Be Defended”), this work-hypothesis theorises “basic warfare” [la guerre fondamentale] as the teleological horizon of socio-political relations. Following Boulainvilliers, Foucault champions this polemological approach, conceived as a purely descriptive discourse on “real” politics and war, against the philosophico-juridical conceptuality attached to liberal society (Hobbes’s Leviathan being here the prime example). \nHowever, in doing so, Foucault did not interrogate the conceptual validity of notions such as power and war, therefore interlinking them without questioning their ontological status. This problematic conflation was partly rectified in 1982, as Foucault proposed a more dynamic definition of power relations: “actions over potential actions”. \nI argue, somewhat polemically, that Foucault’s hermeneutics of power still involves a teleological violence, dependent on a polemological representation of human relations as essentially instrumental: this resembles what Derrida names, in “Heidegger’s Ear”, an “anthropolemology”. However, I show that all conceptualisation of power implies its self-deconstruction. This self-deconstructive (or autoimmune) structure supposes an archi-originary unpower prior to power: power presupposes an excess within power, an excessive force, another violence making it both possible and impossible. There is something within power located “beyond the power principle” (Derrida). This (self-)excess signifies a limitless resistantiality co-extensive with power-relationality. It also allows the reversal of pólemos into its opposite, as unpower opens politics and warfare to the messianic call of a pre-political, pre-ontological disruption: the archi-originary force of différance. This force, unconditional, challenges Foucault’s conceptualisations of power, suggesting an originary performativity located before or beyond hermeneutics of power-knowledge, disrupting theoreticity as well as empiricity by pointing to their ontological complicity.\nThe bulk of this essay is dedicated to sketching the theoretical implications of this deconstructive reading of Foucault with respect to the methodology and conceptuality of political science and social theory.","downloadable_attachments":[{"id":63286010,"asset_id":11958275,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":2357791,"first_name":"Thomas Clément","last_name":"MERCIER","domain_name":"uai","page_name":"T_C_Mercier","display_name":"Thomas Clément MERCIER","profile_url":"https://uai.academia.edu/T_C_Mercier?f_ri=10610","photo":"https://0.academia-photos.com/2357791/743316/55133078/s65_thomas_cl_ment.mercier.jpg"}],"research_interests":[{"id":8,"name":"Critical 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u-tcGrayDarkest"><div class="summarized">Interest in the development of functions that estimate the likelihood of an individual suffering a future cardiovascular disease (CVD) event has increased in recent times (e.g. Framingham sheets, SCORE-Systematic COronary Risk Estimation,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_66611486" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Interest in the development of functions that estimate the likelihood of an individual suffering a future cardiovascular disease (CVD) event has increased in recent times (e.g. Framingham sheets, SCORE-Systematic COronary Risk Estimation, PROCAM, etc.). However, the estimates of absolute risk may show substantial variations between different populations, because of geographical, cultural, social, behavioural and genetic differences, as well as various methodological issues related to the predictive models employed. We sought to calibrate the SCORE equations to the Greek population. We used the SCORE system that offers an estimation of total fatal CVD risk in &quot;high&quot; and &quot;low&quot; CVD risk European countries. The project pulls together a pool of datasets from 12 European countries and 2.7 million person-years of observation. A mathematical procedure to adjust the risk estimates for individual countries was applied, based on local mortality and risk factor prevalence da...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/66611486" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f29e2d7d17eb9c5d7487d0ee2df808ee" rel="nofollow" data-download="{"attachment_id":77734209,"asset_id":66611486,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77734209/download_file?st=MTczMjgwMjA3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1621366" href="https://independent.academia.edu/TFitzgerald">Tony Fitzgerald</a><script data-card-contents-for-user="1621366" type="text/json">{"id":1621366,"first_name":"Tony","last_name":"Fitzgerald","domain_name":"independent","page_name":"TFitzgerald","display_name":"Tony Fitzgerald","profile_url":"https://independent.academia.edu/TFitzgerald?f_ri=10610","photo":"https://0.academia-photos.com/1621366/129476614/118877850/s65_tony.fitzgerald.png"}</script></span></span></li><li class="js-paper-rank-work_66611486 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="66611486"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 66611486, container: ".js-paper-rank-work_66611486", }); 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However, the estimates of absolute risk may show substantial variations between different populations, because of geographical, cultural, social, behavioural and genetic differences, as well as various methodological issues related to the predictive models employed. We sought to calibrate the SCORE equations to the Greek population. We used the SCORE system that offers an estimation of total fatal CVD risk in \u0026quot;high\u0026quot; and \u0026quot;low\u0026quot; CVD risk European countries. The project pulls together a pool of datasets from 12 European countries and 2.7 million person-years of observation. A mathematical procedure to adjust the risk estimates for individual countries was applied, based on local mortality and risk factor prevalence da...","downloadable_attachments":[{"id":77734209,"asset_id":66611486,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":1621366,"first_name":"Tony","last_name":"Fitzgerald","domain_name":"independent","page_name":"TFitzgerald","display_name":"Tony Fitzgerald","profile_url":"https://independent.academia.edu/TFitzgerald?f_ri=10610","photo":"https://0.academia-photos.com/1621366/129476614/118877850/s65_tony.fitzgerald.png"}],"research_interests":[{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=10610","nofollow":false},{"id":10610,"name":"Survival 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type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="58128" href="https://www.academia.edu/Documents/in/Ceramics">Ceramics</a><script data-card-contents-for-ri="58128" type="text/json">{"id":58128,"name":"Ceramics","url":"https://www.academia.edu/Documents/in/Ceramics?f_ri=10610","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=49156686]'), work: {"id":49156686,"title":"Clinical Survival of 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itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32915021" href="https://independent.academia.edu/PochuanHsieh">Po-chuan Hsieh</a><script data-card-contents-for-user="32915021" type="text/json">{"id":32915021,"first_name":"Po-chuan","last_name":"Hsieh","domain_name":"independent","page_name":"PochuanHsieh","display_name":"Po-chuan Hsieh","profile_url":"https://independent.academia.edu/PochuanHsieh?f_ri=10610","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_47540095 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="47540095"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 47540095, container: ".js-paper-rank-work_47540095", }); });</script></li><li class="js-percentile-work_47540095 InlineList-item InlineList-item--bordered hidden 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class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="25436" href="https://www.academia.edu/Documents/in/Stratification">Stratification</a><script data-card-contents-for-ri="25436" 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style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="69096718"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="24731" href="https://www.academia.edu/Documents/in/Apoptosis">Apoptosis</a>, <script data-card-contents-for-ri="24731" type="text/json">{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="33319" href="https://www.academia.edu/Documents/in/Nature">Nature</a>, <script data-card-contents-for-ri="33319" type="text/json">{"id":33319,"name":"Nature","url":"https://www.academia.edu/Documents/in/Nature?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="38650" href="https://www.academia.edu/Documents/in/Cell_Division">Cell Division</a><script data-card-contents-for-ri="38650" type="text/json">{"id":38650,"name":"Cell Division","url":"https://www.academia.edu/Documents/in/Cell_Division?f_ri=10610","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=69096718]'), work: {"id":69096718,"title":"An anti-cancer derivative of butyric acid (pivalyloxmethyl buterate) and daunorubicin cooperatively prolong survival of mice inoculated with monocytic leukaemia cells","created_at":"2022-01-21T23:14:41.328-08:00","url":"https://www.academia.edu/69096718/An_anti_cancer_derivative_of_butyric_acid_pivalyloxmethyl_buterate_and_daunorubicin_cooperatively_prolong_survival_of_mice_inoculated_with_monocytic_leukaemia_cells?f_ri=10610","dom_id":"work_69096718","summary":null,"downloadable_attachments":[{"id":79325956,"asset_id":69096718,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":143245444,"first_name":"Ada","last_name":"Rephaeli","domain_name":"independent","page_name":"ARephaeli","display_name":"Ada Rephaeli","profile_url":"https://independent.academia.edu/ARephaeli?f_ri=10610","photo":"https://0.academia-photos.com/143245444/43725815/34653683/s65_ada.rephaeli.jpg"}],"research_interests":[{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=10610","nofollow":false},{"id":33319,"name":"Nature","url":"https://www.academia.edu/Documents/in/Nature?f_ri=10610","nofollow":false},{"id":38650,"name":"Cell Division","url":"https://www.academia.edu/Documents/in/Cell_Division?f_ri=10610","nofollow":false},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue?f_ri=10610"},{"id":59057,"name":"Acute Myeloid Leukemia","url":"https://www.academia.edu/Documents/in/Acute_Myeloid_Leukemia?f_ri=10610"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation?f_ri=10610"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=10610"},{"id":553283,"name":"Cancer cells","url":"https://www.academia.edu/Documents/in/Cancer_cells?f_ri=10610"},{"id":1010893,"name":"Cancers","url":"https://www.academia.edu/Documents/in/Cancers?f_ri=10610"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents?f_ri=10610"},{"id":3727133,"name":"Daunorubicin","url":"https://www.academia.edu/Documents/in/Daunorubicin?f_ri=10610"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_63401242" data-work_id="63401242" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/63401242/Survival_of_women_with_locally_advanced_breast_cancer_at_a_teaching_hospital_in_Lahore">Survival of women with locally advanced breast cancer at a teaching hospital in Lahore</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To correlate the clinical features of women presenting with locally advanced breast cancer with event-free survival (EFS) and overall survival (OS) and to evaluate the patterns of relapse. A total of 200 patients presenting consecutively... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_63401242" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To correlate the clinical features of women presenting with locally advanced breast cancer with event-free survival (EFS) and overall survival (OS) and to evaluate the patterns of relapse. A total of 200 patients presenting consecutively over 9 years with Stage III breast cancer were evaluated for age, socio-economic status (SES), tumour size and grade, number of involved lymph nodes, stage III sub-categories, estrogen and progesterone receptor (ER/PR) status, treatment profiles and responses, and sites of relapse. EFS and OS at 5 and 10 years were calculated. Median age was 45 years. Poorly differentiated tumours were found in 127 patients, while 128 had larger tumours (T3 and T4). Eighty women had extensive nodal involvement (N2 and N3), and 86 had Stage IIIA tumours. Chemotherapy was given to 44 patients before surgery and one of these patients achieved pathological complete response. At 5 and 10 years, EFS was 25% and 7%, and OS was 52% and 31%, respectively. By Cox regression a...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/63401242" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c02b3d581f3bdd48da92edb54607337e" rel="nofollow" data-download="{"attachment_id":75843954,"asset_id":63401242,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/75843954/download_file?st=MTczMjgwMjA3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34372370" href="https://independent.academia.edu/DrMAsifSaeed">Dr. M. Asif Saeed</a><script data-card-contents-for-user="34372370" type="text/json">{"id":34372370,"first_name":"Dr. M. Asif","last_name":"Saeed","domain_name":"independent","page_name":"DrMAsifSaeed","display_name":"Dr. M. Asif Saeed","profile_url":"https://independent.academia.edu/DrMAsifSaeed?f_ri=10610","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_63401242 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="63401242"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 63401242, container: ".js-paper-rank-work_63401242", }); });</script></li><li class="js-percentile-work_63401242 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63401242; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_63401242"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_63401242 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="63401242"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63401242; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63401242]").text(description); $(".js-view-count-work_63401242").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_63401242").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="63401242"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2066" href="https://www.academia.edu/Documents/in/Research_Design">Research Design</a>, <script data-card-contents-for-ri="2066" type="text/json">{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6802" href="https://www.academia.edu/Documents/in/Breast_Cancer">Breast Cancer</a>, <script data-card-contents-for-ri="6802" type="text/json">{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7361" href="https://www.academia.edu/Documents/in/Pakistan">Pakistan</a>, <script data-card-contents-for-ri="7361" type="text/json">{"id":7361,"name":"Pakistan","url":"https://www.academia.edu/Documents/in/Pakistan?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a><script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=63401242]'), work: {"id":63401242,"title":"Survival of women with locally advanced breast cancer at a teaching hospital in Lahore","created_at":"2021-12-06T22:09:29.531-08:00","url":"https://www.academia.edu/63401242/Survival_of_women_with_locally_advanced_breast_cancer_at_a_teaching_hospital_in_Lahore?f_ri=10610","dom_id":"work_63401242","summary":"To correlate the clinical features of women presenting with locally advanced breast cancer with event-free survival (EFS) and overall survival (OS) and to evaluate the patterns of relapse. A total of 200 patients presenting consecutively over 9 years with Stage III breast cancer were evaluated for age, socio-economic status (SES), tumour size and grade, number of involved lymph nodes, stage III sub-categories, estrogen and progesterone receptor (ER/PR) status, treatment profiles and responses, and sites of relapse. EFS and OS at 5 and 10 years were calculated. Median age was 45 years. Poorly differentiated tumours were found in 127 patients, while 128 had larger tumours (T3 and T4). Eighty women had extensive nodal involvement (N2 and N3), and 86 had Stage IIIA tumours. Chemotherapy was given to 44 patients before surgery and one of these patients achieved pathological complete response. At 5 and 10 years, EFS was 25% and 7%, and OS was 52% and 31%, respectively. By Cox regression a...","downloadable_attachments":[{"id":75843954,"asset_id":63401242,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34372370,"first_name":"Dr. M. Asif","last_name":"Saeed","domain_name":"independent","page_name":"DrMAsifSaeed","display_name":"Dr. M. Asif Saeed","profile_url":"https://independent.academia.edu/DrMAsifSaeed?f_ri=10610","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=10610","nofollow":false},{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=10610","nofollow":false},{"id":7361,"name":"Pakistan","url":"https://www.academia.edu/Documents/in/Pakistan?f_ri=10610","nofollow":false},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=10610"},{"id":70854,"name":"Developing Country","url":"https://www.academia.edu/Documents/in/Developing_Country?f_ri=10610"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=10610"},{"id":158839,"name":"Breast Cancer Research","url":"https://www.academia.edu/Documents/in/Breast_Cancer_Research?f_ri=10610"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=10610"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=10610"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=10610"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=10610"},{"id":2463779,"name":"Combined Modality Therapy","url":"https://www.academia.edu/Documents/in/Combined_Modality_Therapy?f_ri=10610"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms?f_ri=10610"},{"id":3082379,"name":"Disease Free Survival","url":"https://www.academia.edu/Documents/in/Disease_Free_Survival?f_ri=10610"},{"id":3118074,"name":"Neoplasm staging","url":"https://www.academia.edu/Documents/in/Neoplasm_staging?f_ri=10610"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_63134587" data-work_id="63134587" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/63134587/Raltitrexed_eloxatin_salvage_chemotherapy_in_gemcitabine_resistant_metastatic_pancreatic_cancer">Raltitrexed–eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Limited information on salvage treatment in patients affected by pancreatic cancer is available. At failure, about half of the patients present good performance status (PS) and are candidate for further treatment. Patients &gt;18 years,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_63134587" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Limited information on salvage treatment in patients affected by pancreatic cancer is available. At failure, about half of the patients present good performance status (PS) and are candidate for further treatment. Patients &gt;18 years, PS ⩾50, with metastatic pancreatic adenocarcinoma previously treated with gemcitabine-containing chemotherapy, and progression-free survival (PFS) 2 toxicity was: neutropenia in five patients (12%), thrombocytopenia, liver and vomiting in three (7%), fatigue in two (5%). In total, 10 patients (24%) yielded a partial response, 11 a stable disease. Progression-free survival at 6 months was 14.6%. Median survival was 5.2 months. Survival was significantly longer in patients with previous PFS &gt;6 months and in patients without pancreatic localisation. A clinically relevant improvement of quality of life was observed in numerous domains. Raltitrexed–oxaliplatin regimen may constitute a treatment opportunity in gemcitabine-resistant metastatic pancreatic...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/63134587" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e51154b5aa9a0db1a0c4b9bb78407665" rel="nofollow" data-download="{"attachment_id":75657813,"asset_id":63134587,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/75657813/download_file?st=MTczMjgwMjA3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36597974" href="https://independent.academia.edu/LPiemonti">L Piemonti</a><script data-card-contents-for-user="36597974" type="text/json">{"id":36597974,"first_name":"L","last_name":"Piemonti","domain_name":"independent","page_name":"LPiemonti","display_name":"L Piemonti","profile_url":"https://independent.academia.edu/LPiemonti?f_ri=10610","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_63134587 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="63134587"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 63134587, container: ".js-paper-rank-work_63134587", }); 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$(".js-view-count[data-work-id=63134587]").text(description); $(".js-view-count-work_63134587").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_63134587").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="63134587"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="7470" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26623" href="https://www.academia.edu/Documents/in/Pancreatic_Cancer">Pancreatic Cancer</a>, <script data-card-contents-for-ri="26623" type="text/json">{"id":26623,"name":"Pancreatic Cancer","url":"https://www.academia.edu/Documents/in/Pancreatic_Cancer?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="289271" href="https://www.academia.edu/Documents/in/Aged">Aged</a><script data-card-contents-for-ri="289271" type="text/json">{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=10610","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=63134587]'), work: {"id":63134587,"title":"Raltitrexed–eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer","created_at":"2021-12-03T09:12:40.083-08:00","url":"https://www.academia.edu/63134587/Raltitrexed_eloxatin_salvage_chemotherapy_in_gemcitabine_resistant_metastatic_pancreatic_cancer?f_ri=10610","dom_id":"work_63134587","summary":"Limited information on salvage treatment in patients affected by pancreatic cancer is available. At failure, about half of the patients present good performance status (PS) and are candidate for further treatment. Patients \u0026gt;18 years, PS ⩾50, with metastatic pancreatic adenocarcinoma previously treated with gemcitabine-containing chemotherapy, and progression-free survival (PFS) 2 toxicity was: neutropenia in five patients (12%), thrombocytopenia, liver and vomiting in three (7%), fatigue in two (5%). In total, 10 patients (24%) yielded a partial response, 11 a stable disease. Progression-free survival at 6 months was 14.6%. Median survival was 5.2 months. Survival was significantly longer in patients with previous PFS \u0026gt;6 months and in patients without pancreatic localisation. A clinically relevant improvement of quality of life was observed in numerous domains. Raltitrexed–oxaliplatin regimen may constitute a treatment opportunity in gemcitabine-resistant metastatic pancreatic...","downloadable_attachments":[{"id":75657813,"asset_id":63134587,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36597974,"first_name":"L","last_name":"Piemonti","domain_name":"independent","page_name":"LPiemonti","display_name":"L Piemonti","profile_url":"https://independent.academia.edu/LPiemonti?f_ri=10610","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=10610","nofollow":false},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false},{"id":26623,"name":"Pancreatic Cancer","url":"https://www.academia.edu/Documents/in/Pancreatic_Cancer?f_ri=10610","nofollow":false},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=10610","nofollow":false},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=10610"},{"id":1794847,"name":"Progression Free Survival","url":"https://www.academia.edu/Documents/in/Progression_Free_Survival?f_ri=10610"},{"id":1947600,"name":"Quinazolines","url":"https://www.academia.edu/Documents/in/Quinazolines?f_ri=10610"},{"id":3521397,"name":"Pancreatic neoplasms","url":"https://www.academia.edu/Documents/in/Pancreatic_neoplasms?f_ri=10610"},{"id":3602969,"name":"Neoplasm metastasis","url":"https://www.academia.edu/Documents/in/Neoplasm_metastasis?f_ri=10610"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_61366612" data-work_id="61366612" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/61366612/The_Prognosis_Of_Adult_Burkitts_Cell_Leukemia_In_Real_Life_Clinical_Practice">The Prognosis Of Adult Burkitt's Cell Leukemia In Real-Life Clinical Practice</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Many studies reported an improved prognosis in the patients with Burkitt&#39;s lymphoma obviating the need of stem cell transplantation. However, prognosis of the advanced disease (i.e. Burkitt&#39;s cell leukemia) has not been reported... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61366612" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Many studies reported an improved prognosis in the patients with Burkitt&#39;s lymphoma obviating the need of stem cell transplantation. However, prognosis of the advanced disease (i.e. Burkitt&#39;s cell leukemia) has not been reported with current treatment modalities except for a few prospective trials. The aim of this study is to compare the prognoses of the Burkitt&#39;s cell leukemia (BL) patients with similarly treated and not transplanted other types of acute lymphoblastic leukemia (ALL) patients and with ALL cases that underwent allogeneic stem cell transplantation (ASCT) in their first remissions. In this retrospective analysis, BL patients aged between 16 and 63 who admitted between 2000 and 2014 to Hacettepe or Gazi University Hospitals and treated with intensive therapies aiming cure were included in the study. All ALL patients who were treated with a similar protocol not including transplantation during the same period (NTxALL group) and all ALL patients who underwent ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61366612" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="77223f2136482e319ef85fe925e448ad" rel="nofollow" data-download="{"attachment_id":74418756,"asset_id":61366612,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74418756/download_file?st=MTczMjgwMjA3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="97438519" href="https://hacettepe.academia.edu/sezginetg%C3%BCl">sezgin etgül</a><script data-card-contents-for-user="97438519" type="text/json">{"id":97438519,"first_name":"sezgin","last_name":"etgül","domain_name":"hacettepe","page_name":"sezginetgül","display_name":"sezgin etgül","profile_url":"https://hacettepe.academia.edu/sezginetg%C3%BCl?f_ri=10610","photo":"https://0.academia-photos.com/97438519/22036525/21281055/s65_sezgin.etg_l.jpg"}</script></span></span></li><li class="js-paper-rank-work_61366612 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61366612"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61366612, container: ".js-paper-rank-work_61366612", }); });</script></li><li class="js-percentile-work_61366612 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61366612; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_61366612"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_61366612 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="61366612"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61366612; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61366612]").text(description); $(".js-view-count-work_61366612").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_61366612").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="61366612"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="57801" href="https://www.academia.edu/Documents/in/Dexamethasone">Dexamethasone</a><script data-card-contents-for-ri="57801" type="text/json">{"id":57801,"name":"Dexamethasone","url":"https://www.academia.edu/Documents/in/Dexamethasone?f_ri=10610","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=61366612]'), work: {"id":61366612,"title":"The Prognosis Of Adult Burkitt's Cell Leukemia In Real-Life Clinical Practice","created_at":"2021-11-08T21:06:06.519-08:00","url":"https://www.academia.edu/61366612/The_Prognosis_Of_Adult_Burkitts_Cell_Leukemia_In_Real_Life_Clinical_Practice?f_ri=10610","dom_id":"work_61366612","summary":"Many studies reported an improved prognosis in the patients with Burkitt\u0026#39;s lymphoma obviating the need of stem cell transplantation. However, prognosis of the advanced disease (i.e. Burkitt\u0026#39;s cell leukemia) has not been reported with current treatment modalities except for a few prospective trials. The aim of this study is to compare the prognoses of the Burkitt\u0026#39;s cell leukemia (BL) patients with similarly treated and not transplanted other types of acute lymphoblastic leukemia (ALL) patients and with ALL cases that underwent allogeneic stem cell transplantation (ASCT) in their first remissions. In this retrospective analysis, BL patients aged between 16 and 63 who admitted between 2000 and 2014 to Hacettepe or Gazi University Hospitals and treated with intensive therapies aiming cure were included in the study. All ALL patients who were treated with a similar protocol not including transplantation during the same period (NTxALL group) and all ALL patients who underwent ...","downloadable_attachments":[{"id":74418756,"asset_id":61366612,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":97438519,"first_name":"sezgin","last_name":"etgül","domain_name":"hacettepe","page_name":"sezginetgül","display_name":"sezgin etgül","profile_url":"https://hacettepe.academia.edu/sezginetg%C3%BCl?f_ri=10610","photo":"https://0.academia-photos.com/97438519/22036525/21281055/s65_sezgin.etg_l.jpg"}],"research_interests":[{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=10610","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=10610","nofollow":false},{"id":57801,"name":"Dexamethasone","url":"https://www.academia.edu/Documents/in/Dexamethasone?f_ri=10610","nofollow":false},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=10610"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=10610"},{"id":314240,"name":"Doxorubicin","url":"https://www.academia.edu/Documents/in/Doxorubicin?f_ri=10610"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=10610"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=10610"},{"id":906958,"name":"Disease Management","url":"https://www.academia.edu/Documents/in/Disease_Management?f_ri=10610"},{"id":1198588,"name":"Cyclophosphamide","url":"https://www.academia.edu/Documents/in/Cyclophosphamide?f_ri=10610"},{"id":2374838,"name":"Hematopoietic Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell_Transplantation?f_ri=10610"},{"id":3448420,"name":"Vincristine","url":"https://www.academia.edu/Documents/in/Vincristine?f_ri=10610"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_55422739" data-work_id="55422739" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/55422739/Sinonasal_adenoid_cystic_carcinoma_The_M_D_Anderson_Cancer_Center_experience">Sinonasal adenoid cystic carcinoma: The M. D. Anderson Cancer Center experience</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/55422739" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="00b50580b2872e2576c955d813923320" rel="nofollow" data-download="{"attachment_id":71299643,"asset_id":55422739,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/71299643/download_file?st=MTczMjgwMjA3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="45592063" href="https://mdacc.academia.edu/DiannaRoberts">Dianna Roberts</a><script data-card-contents-for-user="45592063" type="text/json">{"id":45592063,"first_name":"Dianna","last_name":"Roberts","domain_name":"mdacc","page_name":"DiannaRoberts","display_name":"Dianna Roberts","profile_url":"https://mdacc.academia.edu/DiannaRoberts?f_ri=10610","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_55422739 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="55422739"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 55422739, container: ".js-paper-rank-work_55422739", }); 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data-has-card-for-ri="6021" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12980" href="https://www.academia.edu/Documents/in/Prostate_Cancer">Prostate Cancer</a>, <script data-card-contents-for-ri="12980" type="text/json">{"id":12980,"name":"Prostate Cancer","url":"https://www.academia.edu/Documents/in/Prostate_Cancer?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" 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and Motor Development Among Infants Born to Women Infected With Human Immunodeficiency Virus</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/9030584" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="58ca4dd040748a7039113f7bf97dcd2a" rel="nofollow" data-download="{"attachment_id":47908804,"asset_id":9030584,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47908804/download_file?st=MTczMjgwMjA3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="20349802" href="https://uprm.academia.edu/ClementeDiaz">Clemente Diaz</a><script data-card-contents-for-user="20349802" type="text/json">{"id":20349802,"first_name":"Clemente","last_name":"Diaz","domain_name":"uprm","page_name":"ClementeDiaz","display_name":"Clemente Diaz","profile_url":"https://uprm.academia.edu/ClementeDiaz?f_ri=10610","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_9030584 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="9030584"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 9030584, container: ".js-paper-rank-work_9030584", }); });</script></li><li class="js-percentile-work_9030584 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 9030584; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_9030584"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_9030584 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="9030584"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 9030584; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=9030584]").text(description); $(".js-view-count-work_9030584").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_9030584").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="9030584"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">24</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="631" href="https://www.academia.edu/Documents/in/Pediatrics">Pediatrics</a>, <script data-card-contents-for-ri="631" type="text/json">{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4117" href="https://www.academia.edu/Documents/in/Motor_Development">Motor Development</a>, <script data-card-contents-for-ri="4117" type="text/json">{"id":4117,"name":"Motor Development","url":"https://www.academia.edu/Documents/in/Motor_Development?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9588" href="https://www.academia.edu/Documents/in/Natural_History">Natural History</a>, <script data-card-contents-for-ri="9588" type="text/json">{"id":9588,"name":"Natural History","url":"https://www.academia.edu/Documents/in/Natural_History?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a><script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=9030584]'), work: {"id":9030584,"title":"Early Cognitive and Motor Development Among Infants Born to Women Infected With Human Immunodeficiency Virus","created_at":"2014-10-30T03:51:45.631-07:00","url":"https://www.academia.edu/9030584/Early_Cognitive_and_Motor_Development_Among_Infants_Born_to_Women_Infected_With_Human_Immunodeficiency_Virus?f_ri=10610","dom_id":"work_9030584","summary":null,"downloadable_attachments":[{"id":47908804,"asset_id":9030584,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":20349802,"first_name":"Clemente","last_name":"Diaz","domain_name":"uprm","page_name":"ClementeDiaz","display_name":"Clemente Diaz","profile_url":"https://uprm.academia.edu/ClementeDiaz?f_ri=10610","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=10610","nofollow":false},{"id":4117,"name":"Motor Development","url":"https://www.academia.edu/Documents/in/Motor_Development?f_ri=10610","nofollow":false},{"id":9588,"name":"Natural History","url":"https://www.academia.edu/Documents/in/Natural_History?f_ri=10610","nofollow":false},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false},{"id":15346,"name":"Puerto Rico","url":"https://www.academia.edu/Documents/in/Puerto_Rico?f_ri=10610"},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=10610"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=10610"},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=10610"},{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=10610"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=10610"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=10610"},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States?f_ri=10610"},{"id":120582,"name":"Infant Development","url":"https://www.academia.edu/Documents/in/Infant_Development?f_ri=10610"},{"id":137145,"name":"Developmental disabilities","url":"https://www.academia.edu/Documents/in/Developmental_disabilities?f_ri=10610"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=10610"},{"id":318308,"name":"Human immunodeficiency virus","url":"https://www.academia.edu/Documents/in/Human_immunodeficiency_virus?f_ri=10610"},{"id":546421,"name":"Educational Status","url":"https://www.academia.edu/Documents/in/Educational_Status?f_ri=10610"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=10610"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=10610"},{"id":749302,"name":"Indexation","url":"https://www.academia.edu/Documents/in/Indexation?f_ri=10610"},{"id":1272981,"name":"Proportional Hazards Models","url":"https://www.academia.edu/Documents/in/Proportional_Hazards_Models?f_ri=10610"},{"id":1423077,"name":"Substance-Related Disorders","url":"https://www.academia.edu/Documents/in/Substance-Related_Disorders?f_ri=10610"},{"id":1627527,"name":"Cognition disorders","url":"https://www.academia.edu/Documents/in/Cognition_disorders?f_ri=10610"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=10610"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27309365" data-work_id="27309365" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27309365/Survival_and_complications_in_patients_with_thalassemia_major_treated_with_transfusion_and_deferoxamine">Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Seven Italian centers reported data on survival, causes of death and appearance of complications in patients with thalassemia major. The interactions between gender, birth cohort, complications, and ferritin on survival and complications... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27309365" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Seven Italian centers reported data on survival, causes of death and appearance of complications in patients with thalassemia major. The interactions between gender, birth cohort, complications, and ferritin on survival and complications were analyzed. Survival after the first decade was studied for 977 patients born since 1960 whereas survival since birth and complication appearance was studied for the 720 patients born after 1970. Better survival was demonstrated for patients born in more recent years (p&lt;0.00005) and for females (p=0.0003); 68% of the patients are alive at the age of 35 years. In the entire population 67% of the deaths were due to heart disease. There was a significant association between birth cohort and complication-free survival (p&lt;0.0005). The prevalence of complications was: heart failure 6.8%, arrhythmia 5.7%, hypogonadism 54.7%, hypothyroidism 10.8%, diabetes 6.4%, HIV infection 1.7%, and thrombosis 1.1%. Lower ferritin levels were associated with a l...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27309365" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="45e39c15dbe7c10675f3eaf532610cc1" rel="nofollow" data-download="{"attachment_id":47565897,"asset_id":27309365,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47565897/download_file?st=MTczMjgwMjA3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32905769" href="https://independent.academia.edu/GianForni">Gian Forni</a><script data-card-contents-for-user="32905769" type="text/json">{"id":32905769,"first_name":"Gian","last_name":"Forni","domain_name":"independent","page_name":"GianForni","display_name":"Gian Forni","profile_url":"https://independent.academia.edu/GianForni?f_ri=10610","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_27309365 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27309365"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27309365, container: ".js-paper-rank-work_27309365", }); });</script></li><li class="js-percentile-work_27309365 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27309365; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_27309365"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_27309365 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="27309365"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27309365; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27309365]").text(description); $(".js-view-count-work_27309365").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27309365").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27309365"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7825" href="https://www.academia.edu/Documents/in/Thalassemia">Thalassemia</a>, <script data-card-contents-for-ri="7825" type="text/json">{"id":7825,"name":"Thalassemia","url":"https://www.academia.edu/Documents/in/Thalassemia?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="45213" href="https://www.academia.edu/Documents/in/Italy">Italy</a>, <script data-card-contents-for-ri="45213" type="text/json">{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a><script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=10610","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27309365]'), work: {"id":27309365,"title":"Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine","created_at":"2016-07-27T08:34:45.298-07:00","url":"https://www.academia.edu/27309365/Survival_and_complications_in_patients_with_thalassemia_major_treated_with_transfusion_and_deferoxamine?f_ri=10610","dom_id":"work_27309365","summary":"Seven Italian centers reported data on survival, causes of death and appearance of complications in patients with thalassemia major. The interactions between gender, birth cohort, complications, and ferritin on survival and complications were analyzed. Survival after the first decade was studied for 977 patients born since 1960 whereas survival since birth and complication appearance was studied for the 720 patients born after 1970. Better survival was demonstrated for patients born in more recent years (p\u0026lt;0.00005) and for females (p=0.0003); 68% of the patients are alive at the age of 35 years. In the entire population 67% of the deaths were due to heart disease. There was a significant association between birth cohort and complication-free survival (p\u0026lt;0.0005). The prevalence of complications was: heart failure 6.8%, arrhythmia 5.7%, hypogonadism 54.7%, hypothyroidism 10.8%, diabetes 6.4%, HIV infection 1.7%, and thrombosis 1.1%. Lower ferritin levels were associated with a l...","downloadable_attachments":[{"id":47565897,"asset_id":27309365,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32905769,"first_name":"Gian","last_name":"Forni","domain_name":"independent","page_name":"GianForni","display_name":"Gian Forni","profile_url":"https://independent.academia.edu/GianForni?f_ri=10610","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7825,"name":"Thalassemia","url":"https://www.academia.edu/Documents/in/Thalassemia?f_ri=10610","nofollow":false},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=10610","nofollow":false},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=10610","nofollow":false},{"id":231186,"name":"Hypothyroidism","url":"https://www.academia.edu/Documents/in/Hypothyroidism?f_ri=10610"},{"id":323090,"name":"Cardiac Arrhythmias","url":"https://www.academia.edu/Documents/in/Cardiac_Arrhythmias?f_ri=10610"},{"id":375034,"name":"Late onset hypogonadism","url":"https://www.academia.edu/Documents/in/Late_onset_hypogonadism?f_ri=10610"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=10610"},{"id":496063,"name":"Thrombosis","url":"https://www.academia.edu/Documents/in/Thrombosis?f_ri=10610"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=10610"},{"id":627890,"name":"Blood Transfusion","url":"https://www.academia.edu/Documents/in/Blood_Transfusion?f_ri=10610"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus?f_ri=10610"},{"id":1491248,"name":"Life tables","url":"https://www.academia.edu/Documents/in/Life_tables?f_ri=10610"},{"id":1800451,"name":"Chelation Therapy","url":"https://www.academia.edu/Documents/in/Chelation_Therapy?f_ri=10610"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=10610"},{"id":2190600,"name":"Splenectomy","url":"https://www.academia.edu/Documents/in/Splenectomy?f_ri=10610"},{"id":2397637,"name":"Deferoxamine","url":"https://www.academia.edu/Documents/in/Deferoxamine?f_ri=10610"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10121643" data-work_id="10121643" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10121643/BAC_array_CGH_distinguishes_mutually_exclusive_alterations_that_define_clinicogenetic_subtypes_of_gliomas">BAC array CGH distinguishes mutually exclusive alterations that define clinicogenetic subtypes of gliomas</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The pathological classification of gliomas constitutes a critical step of the clinical management of patients, yet it is frequently challenging. To assess the relationship between genetic abnormalities and clinicopathological... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10121643" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The pathological classification of gliomas constitutes a critical step of the clinical management of patients, yet it is frequently challenging. To assess the relationship between genetic abnormalities and clinicopathological characteristics, we have performed a genetic and clinical analysis of a series of gliomas. A total of 112 gliomas were analyzed by comparative genomic hybridization on a BAC array with a 1 megabase resolution. Altered regions were identified and correlation analysis enabled to retrieve significant associations and exclusions. Whole chromosomes (chrs) 1p and 19q losses with centromeric breakpoints and EGFR high level amplification were found to be mutually exclusive, permitting identification of 3 distinct, nonoverlapping groups of tumors with striking clinicopathological differences. Type A tumors with chrs 1p and 19q codeletion exhibited an oligodendroglial phenotype and a longer patient survival. Type B tumors were characterized by EGFR amplification. They harbored a WHO high grade of malignancy and a short patient survival. Finally, type C tumors displayed none of the previous patterns but the presence of chr 7 gain, chr 9p deletion and/or chr 10 loss. It included astrocytic tumors in patients younger than in type B and whose prognosis was highly dependent upon the number of alterations. A multivariate analysis based on a Cox model shows that age, WHO grade and genomic type provide complementary prognostic informations. Finally, our results highlight the potential of a whole-genome analysis as an additional diagnostic in cases of unclear conventional genetic findings. © 2007 Wiley-Liss, Inc.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10121643" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7a406e748ce88e053717f45f3ebab5f7" rel="nofollow" data-download="{"attachment_id":47519801,"asset_id":10121643,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47519801/download_file?st=MTczMjgwMjA3OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="24690491" href="https://independent.academia.edu/IsabelBrito4">Isabel Brito</a><script data-card-contents-for-user="24690491" type="text/json">{"id":24690491,"first_name":"Isabel","last_name":"Brito","domain_name":"independent","page_name":"IsabelBrito4","display_name":"Isabel Brito","profile_url":"https://independent.academia.edu/IsabelBrito4?f_ri=10610","photo":"https://0.academia-photos.com/24690491/47254176/36257463/s65_isabel.brito.jpg"}</script></span></span></li><li class="js-paper-rank-work_10121643 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10121643"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10121643, container: ".js-paper-rank-work_10121643", }); 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To assess the relationship between genetic abnormalities and clinicopathological characteristics, we have performed a genetic and clinical analysis of a series of gliomas. A total of 112 gliomas were analyzed by comparative genomic hybridization on a BAC array with a 1 megabase resolution. Altered regions were identified and correlation analysis enabled to retrieve significant associations and exclusions. Whole chromosomes (chrs) 1p and 19q losses with centromeric breakpoints and EGFR high level amplification were found to be mutually exclusive, permitting identification of 3 distinct, nonoverlapping groups of tumors with striking clinicopathological differences. Type A tumors with chrs 1p and 19q codeletion exhibited an oligodendroglial phenotype and a longer patient survival. Type B tumors were characterized by EGFR amplification. They harbored a WHO high grade of malignancy and a short patient survival. Finally, type C tumors displayed none of the previous patterns but the presence of chr 7 gain, chr 9p deletion and/or chr 10 loss. It included astrocytic tumors in patients younger than in type B and whose prognosis was highly dependent upon the number of alterations. A multivariate analysis based on a Cox model shows that age, WHO grade and genomic type provide complementary prognostic informations. Finally, our results highlight the potential of a whole-genome analysis as an additional diagnostic in cases of unclear conventional genetic findings. © 2007 Wiley-Liss, Inc.","downloadable_attachments":[{"id":47519801,"asset_id":10121643,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":24690491,"first_name":"Isabel","last_name":"Brito","domain_name":"independent","page_name":"IsabelBrito4","display_name":"Isabel Brito","profile_url":"https://independent.academia.edu/IsabelBrito4?f_ri=10610","photo":"https://0.academia-photos.com/24690491/47254176/36257463/s65_isabel.brito.jpg"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=10610","nofollow":false},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false},{"id":41482,"name":"Multivariate 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tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=10610"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms?f_ri=10610"},{"id":1649745,"name":"Oligonucleotides","url":"https://www.academia.edu/Documents/in/Oligonucleotides?f_ri=10610"},{"id":1811736,"name":"Oligodendroglioma","url":"https://www.academia.edu/Documents/in/Oligodendroglioma?f_ri=10610"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_26693626" data-work_id="26693626" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/26693626/Prognostic_parameters_contributing_to_palatal_implant_failures_a_long_term_survival_analysis_of_239_patients">Prognostic parameters contributing to palatal implant failures: a long-term survival analysis of 239 patients</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/26693626" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="05690300f81af7454370557e7376f0d0" rel="nofollow" data-download="{"attachment_id":46975853,"asset_id":26693626,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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Men have a higher prevalence than women; the sex ratio varies between 2:1 and 4:1, depending on the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_25382878" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Hepatocellular carcinoma represents the fifth most common cancer worldwide and account for approximately 90% of primary liver cancer. Men have a higher prevalence than women; the sex ratio varies between 2:1 and 4:1, depending on the geographic region. To determine the influence of gender on the clinicopathologic characteristics and survival of patients with hepatocellular carcinoma. A retrospective analysis of medical records was performed in 63 patients with hepatocellular carcinoma and their clinicopathologic features and survival were compared in relation to gender. The data was summarized by descriptive statistics and analysed with SPSS version 11.5. Among these patients, 36 were men (57.1%) with male-to female ratio of 2:1.5, the mean female age was 59.8 years (p=0.054). Serum albumin level was significantly lower in women (p=0.0061).The average size of the tumor was 45.8mm and the difference was not significant (p=0.638). Hepatocellular carcinoma was significantly more preval...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25382878" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3f5e54cec1652e0653f476ee8e04cae9" rel="nofollow" data-download="{"attachment_id":45697502,"asset_id":25382878,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45697502/download_file?st=MTczMjgwMjA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="48701488" href="https://independent.academia.edu/TaharKhalfallah">Tahar Khalfallah</a><script data-card-contents-for-user="48701488" type="text/json">{"id":48701488,"first_name":"Tahar","last_name":"Khalfallah","domain_name":"independent","page_name":"TaharKhalfallah","display_name":"Tahar Khalfallah","profile_url":"https://independent.academia.edu/TaharKhalfallah?f_ri=10610","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_25382878 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25382878"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25382878, container: ".js-paper-rank-work_25382878", }); 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Men have a higher prevalence than women; the sex ratio varies between 2:1 and 4:1, depending on the geographic region. To determine the influence of gender on the clinicopathologic characteristics and survival of patients with hepatocellular carcinoma. A retrospective analysis of medical records was performed in 63 patients with hepatocellular carcinoma and their clinicopathologic features and survival were compared in relation to gender. The data was summarized by descriptive statistics and analysed with SPSS version 11.5. Among these patients, 36 were men (57.1%) with male-to female ratio of 2:1.5, the mean female age was 59.8 years (p=0.054). Serum albumin level was significantly lower in women (p=0.0061).The average size of the tumor was 45.8mm and the difference was not significant (p=0.638). Hepatocellular carcinoma was significantly more preval...","downloadable_attachments":[{"id":45697502,"asset_id":25382878,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":48701488,"first_name":"Tahar","last_name":"Khalfallah","domain_name":"independent","page_name":"TaharKhalfallah","display_name":"Tahar Khalfallah","profile_url":"https://independent.academia.edu/TaharKhalfallah?f_ri=10610","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false},{"id":75837,"name":"Tunisia","url":"https://www.academia.edu/Documents/in/Tunisia?f_ri=10610","nofollow":false},{"id":90987,"name":"Sex ratio","url":"https://www.academia.edu/Documents/in/Sex_ratio?f_ri=10610","nofollow":false},{"id":111972,"name":"Hepatocellular 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href="https://www.academia.edu/24712352/Kidney_retransplantation_in_comparison_with_first_kidney_transplantation">Kidney retransplantation in comparison with first kidney transplantation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">IntroductionThe aim of this study was to depict the outcome of second and third kidney allografts in comparison with first kidney allografts.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24712352" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c8732230f0c3e4aca0924259d6f3a662" rel="nofollow" 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type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=10610","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a><script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=10610","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24712352]'), work: 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trial</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14030573" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="351743580d67c56f8d904b2226ec348c" rel="nofollow" data-download="{"attachment_id":44687191,"asset_id":14030573,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44687191/download_file?st=MTczMjgwMjA4MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i 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