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[{"id":65963022,"identifier":"Attachment_65963022","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":45455726,"created_at":"2021-03-10T08:29:06.557-08:00","from_world_paper_id":166986647,"updated_at":"2024-11-13T21:12:21.710-08:00","_data":{"publisher":"Elsevier BV","grobid_abstract":"The clinical and virological protection induced by an E2 sub-unit marker-vaccine against Classical Swine Fever (CSF) was examined during an experimental infection in vaccinated and non-vaccinated pigs. Forty-®ve pigs were equally distributed over three adjacent pens of an isolation unit, there was only indirect (airborne) contact between pigs in the dierent pens. In pen 3 all pigs were vaccinated twice with 4 weeks interval. Pigs in pens 1 and 2 were not vaccinated. Two weeks after booster vaccination, one randomly selected pig in the middle pen was experimentally inoculated with CSF virus. After the initial virus spread in the infected pen, all pigs in the non-vaccinated adjacent pen were infected. In the vaccinated pen, seven out of 14 pigs became infected during the experiment. Survival analysis showed that virus transmission by direct and indirect contact was signi®cantly p`0X001 delayed in vaccinated pigs as compared to non-vaccinated pigs. In the non-vaccinated pens over 40% of the pigs died and typical clinical signs were noticed. In the vaccinated pen no mortality and no clinical symptoms were observed. Although double vaccination with an E2 sub-unit marker-vaccine was able to prevent the clinical course of the disease it was unable to prevent infection through indirect contact. This ®nding combined with the slow serological response after vaccination will complicate the possible use of the vaccine in emergency vaccination programmes. 7","publication_date":"2000,,","publication_name":"Vaccine","grobid_abstract_attachment_id":"65963022"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"An experimental infection with classical swine fever in E2 sub-unit marker-vaccine vaccinated and in non-vaccinated pigs","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [140080861]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" 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href="https://www.academia.edu/4944733/Evaluation_of_the_epidemiological_importance_of_classical_swine_fever_infected_E2_sub_unit_marker_vaccinated_animals_with_RT_nPCR_positive_blood_samples">Evaluation of the epidemiological importance of classical swine fever infected, E2 sub-unit marker vaccinated animals with RT-nPCR positive blood samples</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="6502808" href="https://independent.academia.edu/AndyHaegeman">Andy Haegeman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health, 2005</p><p class="ds-related-work--abstract ds2-5-body-sm">It has been demonstrated that pigs that have been double vaccinated with an E2 sub-unit marker vaccine and that are infected with classical swine fever virus (CSFV) through a natural contact infection may react positive in a CSFV detecting RT-nPCR test, whereas no virus could be isolated by using the conventional virus isolation (VI) technique. 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href="https://www.academia.edu/34690150/Classical_swine_fever_CSF_marker_vaccine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="16432009" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16432009/Oral_immunisation_of_swine_with_a_classical_swine_fever_vaccine_Chinese_strain_and_transmission_studies_in_rabbits_and_sheep">Oral immunisation of swine with a classical swine fever vaccine (Chinese strain) and transmission studies in rabbits and sheep</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35593715" href="https://massgeneral.academia.edu/MichaelPicard">Michael Picard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Veterinary Microbiology, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Oral immunisation of swine with a classical swine fever vaccine (Chinese strain) and transmission studies in rabbits and sheep","attachmentId":42487204,"attachmentType":"pdf","work_url":"https://www.academia.edu/16432009/Oral_immunisation_of_swine_with_a_classical_swine_fever_vaccine_Chinese_strain_and_transmission_studies_in_rabbits_and_sheep","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/16432009/Oral_immunisation_of_swine_with_a_classical_swine_fever_vaccine_Chinese_strain_and_transmission_studies_in_rabbits_and_sheep"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="20484373" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/20484373/Classical_Swine_Fever_Active_Immunisation_of_Piglets_with_Subunit_E2_Vaccine_in_the_Presence_of_Different_Levels_of_Colostral_Immunity_China_Strain_">Classical Swine Fever: Active Immunisation of Piglets with Subunit (E2) Vaccine in the Presence of Different Levels of Colostral Immunity (China Strain)</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3093787" href="https://independent.academia.edu/TamasPetrovic">Tamas Petrovic</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Veterinaria, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Classical Swine Fever: Active Immunisation of Piglets with Subunit (E2) Vaccine in the Presence of Different Levels of Colostral Immunity (China Strain)","attachmentId":41397861,"attachmentType":"pdf","work_url":"https://www.academia.edu/20484373/Classical_Swine_Fever_Active_Immunisation_of_Piglets_with_Subunit_E2_Vaccine_in_the_Presence_of_Different_Levels_of_Colostral_Immunity_China_Strain_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/20484373/Classical_Swine_Fever_Active_Immunisation_of_Piglets_with_Subunit_E2_Vaccine_in_the_Presence_of_Different_Levels_of_Colostral_Immunity_China_Strain_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="18486220" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18486220/Comparison_of_antibody_values_in_sera_of_pigs_vaccinated_with_a_subunit_or_an_attenuated_vaccine_against_classical_swine_fever">Comparison of antibody values in sera of pigs vaccinated with a subunit or an attenuated vaccine against classical swine fever</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38507898" href="https://independent.academia.edu/LJemer%C5%A1i%C4%87">L. Jemeršić</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Veterinary research communications, 2003</p><p class="ds-related-work--abstract ds2-5-body-sm">Ten pigs, aged 85 days, were vaccinated with a subunit vaccine containing 32 microg of classical swine fever virus glycoprotein E2 (gp E2) (group 1), and a further 10 pigs were vaccinated with a C strain vaccine (10(4+/-0.15) TCID50/ml), produced by amplification in minipig kidney (MPK) cell culture (group 2). Nine non-vaccinated pigs served as a control group (group 3). Serum samples were collected before (day 0) and at 4, 10, 21 and 28 days after vaccination and were analysed by two commercially available enzyme immunoassays and by a neutralizing peroxidase-linked assay (NPLA). At the same times, peripheral blood was taken for determining the total leukocyte count and the body temperature was taken daily. Antibodies were not detected in serum samples collected before vaccination (day 0), and no side-effects that could be connected with vaccination were observed during the trial. Ten days after vaccination 6/10 pigs vaccinated with the subunit vaccine were seropositive. On days 21 ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Comparison of antibody values in sera of pigs vaccinated with a subunit or an attenuated vaccine against classical swine fever","attachmentId":40089623,"attachmentType":"pdf","work_url":"https://www.academia.edu/18486220/Comparison_of_antibody_values_in_sera_of_pigs_vaccinated_with_a_subunit_or_an_attenuated_vaccine_against_classical_swine_fever","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18486220/Comparison_of_antibody_values_in_sera_of_pigs_vaccinated_with_a_subunit_or_an_attenuated_vaccine_against_classical_swine_fever"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="107735104" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/107735104/An_experimental_infection_with_classical_swine_fever_in_weaner_pigs_Transmission_of_the_virus_course_of_the_disease_and_antibody_response">An experimental infection with classical swine fever in weaner pigs. 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