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In this retrospective study, neutropenia was experienced by 112/395 patients (28%) during the first year posttransplant. The only factor found to be significantly associated with the occurrence of neutropenia was combined tacrolimusmycophenolate therapy (p \u003c 0.001). Neutropenic patients experienced more bacterial infections (43% vs. 32%, p = 0.04). Grade of neutropenia correlated with the global risk of infection. Discontinuation of mycophenolic acid (MPA) due to neutropenia was associated with an increased incidence of acute rejection (odds ratios per day 1.11, 95% confidence intervals 1.02-1.22) but not with reduced renal function at 1 year. The time from onset of neutropenia to MPA discontinuation correlated with the duration of neutropenia. Granulocyte colony-stimulating factor (G-CSF) administration was safe and effective in severely neutropenic kidney graft recipients, with absolute neutrophil count \u003e1000/lL achieved in a mean of 1.5 ± 0.5 days. Neutropenia is an important and frequent laboratory finding that may exert a significant influence on outcomes in kidney transplantation. As well as leading to an increased incidence of infection, it is associated with a higher rate of allograft rejection if MPA is discontinued for \u003e6 days (p = 0.02). G-CSF accelerates recovery of neutropenia and may be a good therapeutic alternative for severely neutropenic patients.","publication_date":"2009,,","publication_name":"American Journal of Transplantation","grobid_abstract_attachment_id":"45057643"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Incidence, Risk Factors and Clinical Consequences of Neutropenia Following Kidney Transplantation: A Retrospective Study","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [47671530]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" 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href="https://www.academia.edu/118150649/Use_of_Biosimilar_G_CSF_for_Prevention_of_Chemotherapy_Induced_Neutropenia_Pooled_Analysis_of_Clinical_Usage_Studies"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="123695618" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/123695618/Is_Granulocyte_Colony_stimulating_Factor_Safe_in_the_Treatment_of_Febrile_Neutropenia_in_Lymphoma_Patients_with_Renal_Transplantation">Is Granulocyte Colony-stimulating Factor Safe in the Treatment of Febrile Neutropenia in Lymphoma Patients with Renal Transplantation?</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm 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js-related-work-grid-card-view-pdf" href="https://www.academia.edu/123695618/Is_Granulocyte_Colony_stimulating_Factor_Safe_in_the_Treatment_of_Febrile_Neutropenia_in_Lymphoma_Patients_with_Renal_Transplantation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="15" data-entity-id="26798425" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26798425/Delayed_Recovery_of_Neutrophil_Counts_After_Peripheral_Stem_Cell_Transplantation_Which_Improved_with_Administration_of_a_Minimal_Dose_of_G_CSF_A_Case_Report">Delayed Recovery of Neutrophil Counts After Peripheral Stem Cell Transplantation Which Improved with Administration of a Minimal Dose of G-CSF: A Case Report</a><div 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