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One of the major side effects of potent immunosuppressant is leukopenia. Granulocyte colony stimulating factor (G-CSF) is a cytokine agent which is increasing life span and functional activity of mature neutrophils. G-CSF is a well-established treatment of chemotherapy-induced leukopenia, during hematopoietic stem cell transplantation and HIV infection neutropenia. There were several studies in animal models of liver diseases which showed hematopoietic stem cell mobilization into the injured liver and their differentiation to hepatocytes. There were a few clinical trials in human after development of neutropenia in post liver transplantation (LTx) periods. This study was designed as a pilot study to evaluate the safety of G-CSF on leukopenia in early post LTx periods. Seventeen leukopenic patients in 4 weeks after LTx entered to the study and randomized in one to one manner in this open-label study. Treatment group received 0.3 mg of G-CSF (PD -G-CSF) at the time of leukopenia (≤3000/mm 3 ) and short-term patient's and graft survival were determined. Data are reported as mean, and all data were analyzed using Chi-square and Student's t-test. (SPSS of ware, version 14) p\u003c0.05 were considered significant. 9 patients in the control group and 8 patients recruited in the treatment group. There were no significant differences in days of hospital admission (p: 0.244), microbiologic active cultures (p: 0.30), Oropharyngeal candidiasis (p: 0.30), acute cellular rejection (ACR) (p: 0.437), and day of desirable mycophenolate mofetil dosage achievement (p: 0.691) and episodes of ACR treatments (p: 0.08). Our open-labeled pilot study shows that single dose of G-CSF in leukopenic post liver transplant patients is safe. Although there was no statistically significant beneficial effect on hospital stay, opportunistic, and surgical site infections, but there was a trend toward less ACR episodes in the treatment group. Whether single dosage has a beneficial effect on liver function, survival, rejection, and hospital stay needs further research in another clinical trial.","publication_date":"2014,9,2","publication_name":"Asian Journal of Pharmaceutical and Clinical Research","grobid_abstract_attachment_id":"46910613"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Single Dose of G-CSF in Leukopenia After Post Liver Transplant","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [50610668]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" 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20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Single Dose of G-CSF in Leukopenia After Post Liver Transplant</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="50610668" href="https://independent.academia.edu/AliShayesteh"><img alt="Profile image of Ali Shayesteh" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Ali Shayesteh</a></div><p class="ds-work-card--detail ds2-5-body-sm">2014, Asian Journal of Pharmaceutical and Clinical Research</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" 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data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="14396067" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14396067/Use_of_granulocyte_macrophage_colony_stimulating_factor_in_children_after_orthotopic_liver_transplantation">Use of granulocyte macrophage colony stimulating factor in children after orthotopic liver transplantation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33340424" href="https://independent.academia.edu/EtienneSokal">Etienne Sokal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of 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In this study, recombinant human granulocyte colony-stimulating factor (rhG-CSF), a hematopoietic growth factor that selectively stimulates neutrophil colony formation and neutrophil cell differentiation, was tested for safety and efficacy. We evaluated 30 episodes of leukopenia (&lt;2000/mm3) in 19 kidney graft recipients treated with rhG-CSF. This cohort was compared with an age- and sex-matched historical control group without therapy. Peripheral and differential blood cell counts were analyzed, and the duration of leukopenia was estimated. Furthermore, the occurrence of infections associated with leukopenia was investigated. All patients responded to rhG-CSF therapy. Peripheral leukocyte counts increased from 1756+/-582 to a peak of 8723+/-3038/mm3 (P&lt;0.0001). On the average, the peak was reached after 2.7 days (rang...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Recombinant human granulocyte colony-stimulating factor after kidney transplantation: a retrospective analysis to evaluate the benefit or risk of immunostimulation","attachmentId":80221344,"attachmentType":"pdf","work_url":"https://www.academia.edu/70487406/Recombinant_human_granulocyte_colony_stimulating_factor_after_kidney_transplantation_a_retrospective_analysis_to_evaluate_the_benefit_or_risk_of_immunostimulation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/70487406/Recombinant_human_granulocyte_colony_stimulating_factor_after_kidney_transplantation_a_retrospective_analysis_to_evaluate_the_benefit_or_risk_of_immunostimulation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="117822106" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/117822106/Standart_Prophylactic_Granulocyte_Colony_Stimulating_Factor_Usage_As_A_Part_Of_Autologous_Stem_Cell_Transplantati_on_Procedure">Standart Prophylactic Granulocyte Colony Stimulating Factor Usage As A Part Of Autologous Stem Cell Transplantati̇on Procedure</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="303240557" href="https://independent.academia.edu/FerdaCan">Ferda Can</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Oncologica Turcica, 2022</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Standart Prophylactic Granulocyte Colony Stimulating Factor Usage As A Part Of Autologous Stem Cell Transplantati̇on Procedure","attachmentId":113586237,"attachmentType":"pdf","work_url":"https://www.academia.edu/117822106/Standart_Prophylactic_Granulocyte_Colony_Stimulating_Factor_Usage_As_A_Part_Of_Autologous_Stem_Cell_Transplantati_on_Procedure","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="221803297" href="https://independent.academia.edu/PeterReimnitz">Peter Reimnitz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Transplantation, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial of Efficacy and Safety of Granulocyte Colony-Stimulating Factor in Liver Transplant RECIPIENTS1","attachmentId":112675404,"attachmentType":"pdf","work_url":"https://www.academia.edu/116586596/Randomized_Placebo_Controlled_Double_Blind_Multicenter_Trial_of_Efficacy_and_Safety_of_Granulocyte_Colony_Stimulating_Factor_in_Liver_Transplant_RECIPIENTS1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span 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class="ds-related-work--metadata ds2-5-body-xs">Transplantation Proceedings, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mycophenolate Mofetil–Induced Neutropenia in Liver Transplantation","attachmentId":44821841,"attachmentType":"pdf","work_url":"https://www.academia.edu/13901012/Mycophenolate_Mofetil_Induced_Neutropenia_in_Liver_Transplantation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/13901012/Mycophenolate_Mofetil_Induced_Neutropenia_in_Liver_Transplantation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="86659533" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/86659533/Increase_in_short_term_risk_of_rejection_in_heart_transplant_patients_receiving_granulocyte_colony_stimulating_factor">Increase in short-term risk of rejection in heart transplant patients receiving granulocyte colony-stimulating factor</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42979401" href="https://illinois.academia.edu/StephanieBesser">Stephanie Besser</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2018</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="13" data-entity-id="99843336" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99843336/Characteristics_and_outcomes_of_neutropenia_after_orthotopic_liver_transplantation">Characteristics and outcomes of neutropenia after orthotopic liver transplantation</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="18148165" href="https://tuftsmedicalcenter.academia.edu/NatalieNierenberg">Natalie Nierenberg</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Liver Transplantation, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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data-collection-position="14" data-entity-id="3805108" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/3805108/A_randomized_study_comparing_the_effect_of_GM_CSF_and_G_CSF_on_immune_reconstitution_after_autologous_bone_marrow_transplantation">A randomized study comparing the effect of GM-CSF and G-CSF on immune reconstitution after autologous bone marrow transplantation</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4679311" href="https://independent.academia.edu/LourdesVazquez">Lourdes Vazquez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">British Journal of Haematology, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A randomized 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js-related-work-sidebar-card" data-collection-position="15" data-entity-id="23058431" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23058431/Feasibility_and_safety_of_G_CSF_administration_to_induce_bone_marrow_derived_cells_mobilization_in_patients_with_end_stage_liver_disease">Feasibility and safety of G-CSF administration to induce bone marrow-derived cells mobilization in patients with end stage liver disease</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44797133" href="https://independent.academia.edu/GaiaS">Silvia Gaia</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Hepatology, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="16" data-entity-id="23062971" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23062971/Studies_of_oral_neutrophil_levels_in_patients_receiving_G_CSF_after_autologous_marrow_transplantation">Studies of oral neutrophil levels in patients receiving G-CSF after autologous marrow transplantation</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44803638" href="https://independent.academia.edu/WilliamSheridan7">William Sheridan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">British Journal of Haematology, 1992</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link 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Jabour</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Hepatology, 1994</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The use of granulocyte-macrophage colony-stimulating factor to enhance hematologic parameters of patients with cirrhosis and hypersplenism","attachmentId":41902155,"attachmentType":"pdf","work_url":"https://www.academia.edu/21381903/The_use_of_granulocyte_macrophage_colony_stimulating_factor_to_enhance_hematologic_parameters_of_patients_with_cirrhosis_and_hypersplenism","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/21381903/The_use_of_granulocyte_macrophage_colony_stimulating_factor_to_enhance_hematologic_parameters_of_patients_with_cirrhosis_and_hypersplenism"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="18" data-entity-id="121425869" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/121425869/A_randomized_trial_of_granulocyte_colony_stimulating_factor_Neupogen_starting_day_1_vs_day_7_post_autologous_stem_cell_transplantation">A randomized trial of granulocyte colony-stimulating factor (Neupogen) starting day 1 vs day 7 post-autologous stem cell transplantation</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="26722332" href="https://independent.academia.edu/HopkinsHarry">Harry Hopkins</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Bone Marrow Transplantation, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A randomized trial of granulocyte colony-stimulating factor (Neupogen) starting day 1 vs day 7 post-autologous stem cell transplantation","attachmentId":116778221,"attachmentType":"pdf","work_url":"https://www.academia.edu/121425869/A_randomized_trial_of_granulocyte_colony_stimulating_factor_Neupogen_starting_day_1_vs_day_7_post_autologous_stem_cell_transplantation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/121425869/A_randomized_trial_of_granulocyte_colony_stimulating_factor_Neupogen_starting_day_1_vs_day_7_post_autologous_stem_cell_transplantation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div></div></div><div class="footer--content"><ul class="footer--main-links hide-on-mobile"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/hiring"><svg style="width: 13px; 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