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href="https://www.academia.edu/26798485/Eltrombopag_for_treatment_of_thrombocytopenia_after_allogeneic_hematopoietic_cell_transplantation"><img alt="Research paper thumbnail of Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798485/Eltrombopag_for_treatment_of_thrombocytopenia_after_allogeneic_hematopoietic_cell_transplantation">Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation</a></div><div class="wp-workCard_item"><span>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</span><span>, Jan 16, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Persistent thrombocytopenia is a common complication after allogeneic hematopoietic cell transpla...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Persistent thrombocytopenia is a common complication after allogeneic hematopoietic cell transplantation (HCT). Eltrombopag is an oral thrombopoietin receptor agonist whose efficacy against persistent thrombocytopenia after allogeneic HCT has not been well characterized. This retrospective study evaluated the safety and efficacy of eltrombopag in 12 consecutive patients with persistent thrombocytopenia after allogeneic HCT. Eltrombopag was started at 12.5 mg once daily and the dose was increased by 12.5 mg daily every week until platelet counts exceeded 50,000/μL. Five patients had prolonged isolated thrombocytopenia (PIT) and 7 patients had secondary failure of platelet recovery (SFPR). The cumulative incidence rate of successful platelet recovery to ≥50,000/μL without transfusion support was 60% in PIT patients and 71% in SFPR patients. No patients discontinued the drug because of adverse events or intolerability. Notably, the rate of platelet recovery was higher (100% versus 58%;...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798485"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798485"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798485; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798485]").text(description); $(".js-view-count[data-work-id=26798485]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798485; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798485']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798485, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26798485]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798485,"title":"Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation","translated_title":"","metadata":{"abstract":"Persistent thrombocytopenia is a common complication after allogeneic hematopoietic cell transplantation (HCT). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798484"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798484/Outcomes_of_patients_with_acute_leukaemia_who_relapsed_after_reduced_intensity_stem_cell_transplantation_from_HLA_identical_or_one_antigen_mismatched_related_donors"><img alt="Research paper thumbnail of Outcomes of patients with acute leukaemia who relapsed after reduced-intensity stem cell transplantation from HLA-identical or one antigen-mismatched related donors" class="work-thumbnail" src="https://attachments.academia-assets.com/47072714/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798484/Outcomes_of_patients_with_acute_leukaemia_who_relapsed_after_reduced_intensity_stem_cell_transplantation_from_HLA_identical_or_one_antigen_mismatched_related_donors">Outcomes of patients with acute leukaemia who relapsed after reduced-intensity stem cell transplantation from HLA-identical or one antigen-mismatched related donors</a></div><div class="wp-workCard_item"><span>British Journal of Haematology</span><span>, Jun 1, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b0d04b0d60a9b626de85d10018cc17f4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47072714,"asset_id":26798484,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47072714/download_file?st=MTczMjg5Mjk4Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798484"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798484"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798484; 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href="https://www.academia.edu/26798483/Granisetron_in_the_prevention_of_vomiting_induced_by_conditioning_for_stem_cell_transplantation_A_prospective_randomized_study"><img alt="Research paper thumbnail of Granisetron in the prevention of vomiting induced by conditioning for stem cell transplantation: A prospective randomized study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798483/Granisetron_in_the_prevention_of_vomiting_induced_by_conditioning_for_stem_cell_transplantation_A_prospective_randomized_study">Granisetron in the prevention of vomiting induced by conditioning for stem cell transplantation: A prospective randomized study</a></div><div class="wp-workCard_item"><span>Bone Marrow Transplantation</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We conducted a prospective randomized study to compare granisetron, a 5-hydroxytryptamine-3 recep...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We conducted a prospective randomized study to compare granisetron, a 5-hydroxytryptamine-3 receptor antagonist with standard anti-emetics (control group) consisting mainly of metoclopramide, in the prophylaxis of emesis induced by conditioning prior to stem cell transplantation. Fifty-eight patients were evaluable for analysis. The number of emetic episodes expressed in terms of patient-days was significantly lower in the granisetron group than in the control group (P &amp;lt; 0.001). During the first 24 h of conditioning, 27 of the 31 patients (87.1%) in the granisetron group achieved control of emesis with less than three emetic episodes (major &amp;lt; or = ) a day compared with 37.0% in the control group (P &amp;lt; 0.001). The same degree of emesis control was maintained throughout the conditioning period in 51.% of patients in the granisetron group compared with 0% in the control group (P &amp;lt; 0.001). Adverse reactions were observed in 11.4% of patients in the granisetron group and in 25.9% in the control group. None of the events were serious. Based on these data, we conclude that granisetron is superior to standard antiemetics in protecting against the vomiting induced by conditioning for stem cell transplantation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798483"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798483"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798483; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798483]").text(description); $(".js-view-count[data-work-id=26798483]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798483; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798483']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798483, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26798483]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798483,"title":"Granisetron in the prevention of vomiting induced by conditioning for stem cell transplantation: A prospective randomized study","translated_title":"","metadata":{"abstract":"We conducted a prospective randomized study to compare granisetron, a 5-hydroxytryptamine-3 receptor antagonist with standard anti-emetics (control group) consisting mainly of metoclopramide, in the prophylaxis of emesis induced by conditioning prior to stem cell transplantation. Fifty-eight patients were evaluable for analysis. The number of emetic episodes expressed in terms of patient-days was significantly lower in the granisetron group than in the control group (P \u0026amp;lt; 0.001). During the first 24 h of conditioning, 27 of the 31 patients (87.1%) in the granisetron group achieved control of emesis with less than three emetic episodes (major \u0026amp;lt; or = ) a day compared with 37.0% in the control group (P \u0026amp;lt; 0.001). The same degree of emesis control was maintained throughout the conditioning period in 51.% of patients in the granisetron group compared with 0% in the control group (P \u0026amp;lt; 0.001). Adverse reactions were observed in 11.4% of patients in the granisetron group and in 25.9% in the control group. None of the events were serious. Based on these data, we conclude that granisetron is superior to standard antiemetics in protecting against the vomiting induced by conditioning for stem cell transplantation.","publication_name":"Bone Marrow Transplantation"},"translated_abstract":"We conducted a prospective randomized study to compare granisetron, a 5-hydroxytryptamine-3 receptor antagonist with standard anti-emetics (control group) consisting mainly of metoclopramide, in the prophylaxis of emesis induced by conditioning prior to stem cell transplantation. Fifty-eight patients were evaluable for analysis. The number of emetic episodes expressed in terms of patient-days was significantly lower in the granisetron group than in the control group (P \u0026amp;lt; 0.001). During the first 24 h of conditioning, 27 of the 31 patients (87.1%) in the granisetron group achieved control of emesis with less than three emetic episodes (major \u0026amp;lt; or = ) a day compared with 37.0% in the control group (P \u0026amp;lt; 0.001). The same degree of emesis control was maintained throughout the conditioning period in 51.% of patients in the granisetron group compared with 0% in the control group (P \u0026amp;lt; 0.001). Adverse reactions were observed in 11.4% of patients in the granisetron group and in 25.9% in the control group. None of the events were serious. Based on these data, we conclude that granisetron is superior to standard antiemetics in protecting against the vomiting induced by conditioning for stem cell 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href="https://www.academia.edu/20734080/Allogeneic_hematopoietic_stem_cell_transplantation_with_a_reduced_intensity_conditioning_regimen_for_treatment_of_metastatic_renal_cell_carcinoma_single_institution_experience_with_a_minimum_1_year_follow_up"><img alt="Research paper thumbnail of Allogeneic hematopoietic stem cell transplantation with a reduced-intensity conditioning regimen for treatment of metastatic renal cell carcinoma: single institution experience with a minimum 1-year follow-up" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20734080/Allogeneic_hematopoietic_stem_cell_transplantation_with_a_reduced_intensity_conditioning_regimen_for_treatment_of_metastatic_renal_cell_carcinoma_single_institution_experience_with_a_minimum_1_year_follow_up">Allogeneic hematopoietic stem cell transplantation with a reduced-intensity conditioning regimen for treatment of metastatic renal cell carcinoma: single institution experience with a minimum 1-year follow-up</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/TadaoKakizoe">Tadao Kakizoe</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RyujiTanosaki">Ryuji Tanosaki</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/TohruNakagawa">Tohru Nakagawa</a></span></div><div class="wp-workCard_item"><span>Experimental Hematology</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ObjectiveThe aim of this study was to evaluate the safety and efficacy of allogeneic hematopoieti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ObjectiveThe aim of this study was to evaluate the safety and efficacy of allogeneic hematopoietic stem cell transplantation with a reduced-intensity conditioning regimen (RIST) for interferon-α–refractory metastatic renal cell carcinoma (RCC).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span 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Transplantation","url":"https://www.academia.edu/Documents/in/Stem_Cell_Transplantation"},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease"},{"id":105308,"name":"Renal cell Carcinoma","url":"https://www.academia.edu/Documents/in/Renal_cell_Carcinoma"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":1190789,"name":"Nephrectomy","url":"https://www.academia.edu/Documents/in/Nephrectomy"}],"urls":[{"id":6231462,"url":"http://www.sciencedirect.com/science/article/pii/S0301472X04001067"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798482"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798482/Balance_between_acute_graft_versus_host_disease_and_graft_versus_tumor_effect_after_reduced_intensity_transplantation_for_metastatic_renal_cell_carcinoma"><img alt="Research paper thumbnail of Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798482/Balance_between_acute_graft_versus_host_disease_and_graft_versus_tumor_effect_after_reduced_intensity_transplantation_for_metastatic_renal_cell_carcinoma">Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma</a></div><div class="wp-workCard_item"><span>The hematology journal : the official journal of the European Haematology Association / EHA</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for met...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798482"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798482"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798482; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798482]").text(description); $(".js-view-count[data-work-id=26798482]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798482; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798482']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798482, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26798482]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798482,"title":"Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma","translated_title":"","metadata":{"abstract":"We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"The hematology journal : the official journal of the European Haematology Association / EHA"},"translated_abstract":"We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.","internal_url":"https://www.academia.edu/26798482/Balance_between_acute_graft_versus_host_disease_and_graft_versus_tumor_effect_after_reduced_intensity_transplantation_for_metastatic_renal_cell_carcinoma","translated_internal_url":"","created_at":"2016-07-07T00:18:33.756-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50796887,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Balance_between_acute_graft_versus_host_disease_and_graft_versus_tumor_effect_after_reduced_intensity_transplantation_for_metastatic_renal_cell_carcinoma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50796887,"first_name":"Ryuji","middle_initials":null,"last_name":"Tanosaki","page_name":"RyujiTanosaki","domain_name":"independent","created_at":"2016-07-07T00:15:48.786-07:00","display_name":"Ryuji Tanosaki","url":"https://independent.academia.edu/RyujiTanosaki"},"attachments":[],"research_interests":[{"id":37864,"name":"Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Stem_Cell_Transplantation"},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease"},{"id":105308,"name":"Renal cell Carcinoma","url":"https://www.academia.edu/Documents/in/Renal_cell_Carcinoma"},{"id":2471455,"name":"Acute Disease","url":"https://www.academia.edu/Documents/in/Acute_Disease"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798481"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798481/Long_term_follow_up_system_after_allogeneic_hematopoietic_stem_cell_transplantation_a_single_center_feasibility_study"><img alt="Research paper thumbnail of Long-term follow-up system after allogeneic hematopoietic stem cell transplantation: a single-center feasibility study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798481/Long_term_follow_up_system_after_allogeneic_hematopoietic_stem_cell_transplantation_a_single_center_feasibility_study">Long-term follow-up system after allogeneic hematopoietic stem cell transplantation: a single-center feasibility study</a></div><div class="wp-workCard_item"><span>Journal of Hematopoietic Cell Transplantation</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Long-term survivors after allogeneic hematopoietic cell transplantation (allo-HCT) are a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Long-term survivors after allogeneic hematopoietic cell transplantation (allo-HCT) are at risk for developing late complications. To assess the feasibility of long-term follow-up (LTFU) system for allo-HCT survivors, we performed a feasibility study at our center. Patients aged 20 or above who received their first allo-HCT at our center were prospectively enrolled. Patients who had recurrent malignancy were not eligible. LTFU visits were scheduled at 1, 3, 6 months and every 1 year after allo-HCT. Regular blood test, performance status, body weight, graft-versus-host disease, pulmonary function, chest X-ray, disease status, thyroid function, bone density and immune recovery were assessed at each visit. Quality of life (QOL) was also assessed using the FACT-BMT and SF-36. Forty-seven patients with a median age of 55 years and a median follow-up of 24 months (range, 3 months to 7 years) were enrolled during the 6-month study period. Proportions of patients who completed scheduled screening tests ranged from 64 to 100%, and 32% of the participants completed all the screening tests. Fifty-seven percent of participants returned the QOL questionnaires. In conclusion, the LTFU system was feasible at our center, although a more systematic ordering system and tools to capture specific problems after allo-HCT are warranted.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798481"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798481"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798481; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798481]").text(description); $(".js-view-count[data-work-id=26798481]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798481; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798481']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798481, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26798481]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798481,"title":"Long-term follow-up system after allogeneic hematopoietic stem cell transplantation: a single-center feasibility study","translated_title":"","metadata":{"abstract":"ABSTRACT Long-term survivors after allogeneic hematopoietic cell transplantation (allo-HCT) are at risk for developing late complications. To assess the feasibility of long-term follow-up (LTFU) system for allo-HCT survivors, we performed a feasibility study at our center. Patients aged 20 or above who received their first allo-HCT at our center were prospectively enrolled. Patients who had recurrent malignancy were not eligible. LTFU visits were scheduled at 1, 3, 6 months and every 1 year after allo-HCT. Regular blood test, performance status, body weight, graft-versus-host disease, pulmonary function, chest X-ray, disease status, thyroid function, bone density and immune recovery were assessed at each visit. Quality of life (QOL) was also assessed using the FACT-BMT and SF-36. Forty-seven patients with a median age of 55 years and a median follow-up of 24 months (range, 3 months to 7 years) were enrolled during the 6-month study period. Proportions of patients who completed scheduled screening tests ranged from 64 to 100%, and 32% of the participants completed all the screening tests. Fifty-seven percent of participants returned the QOL questionnaires. In conclusion, the LTFU system was feasible at our center, although a more systematic ordering system and tools to capture specific problems after allo-HCT are warranted.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of Hematopoietic Cell Transplantation"},"translated_abstract":"ABSTRACT Long-term survivors after allogeneic hematopoietic cell transplantation (allo-HCT) are at risk for developing late complications. To assess the feasibility of long-term follow-up (LTFU) system for allo-HCT survivors, we performed a feasibility study at our center. Patients aged 20 or above who received their first allo-HCT at our center were prospectively enrolled. Patients who had recurrent malignancy were not eligible. LTFU visits were scheduled at 1, 3, 6 months and every 1 year after allo-HCT. Regular blood test, performance status, body weight, graft-versus-host disease, pulmonary function, chest X-ray, disease status, thyroid function, bone density and immune recovery were assessed at each visit. Quality of life (QOL) was also assessed using the FACT-BMT and SF-36. Forty-seven patients with a median age of 55 years and a median follow-up of 24 months (range, 3 months to 7 years) were enrolled during the 6-month study period. Proportions of patients who completed scheduled screening tests ranged from 64 to 100%, and 32% of the participants completed all the screening tests. Fifty-seven percent of participants returned the QOL questionnaires. In conclusion, the LTFU system was feasible at our center, although a more systematic ordering system and tools to capture specific problems after allo-HCT are warranted.","internal_url":"https://www.academia.edu/26798481/Long_term_follow_up_system_after_allogeneic_hematopoietic_stem_cell_transplantation_a_single_center_feasibility_study","translated_internal_url":"","created_at":"2016-07-07T00:18:33.603-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50796887,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22150204,"work_id":26798481,"tagging_user_id":50796887,"tagged_user_id":null,"co_author_invite_id":4944612,"email":"t***0@gmail.com","display_order":0,"name":"Tetsuya Fukuda","title":"Long-term follow-up system after allogeneic hematopoietic stem cell transplantation: a single-center feasibility study"}],"downloadable_attachments":[],"slug":"Long_term_follow_up_system_after_allogeneic_hematopoietic_stem_cell_transplantation_a_single_center_feasibility_study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50796887,"first_name":"Ryuji","middle_initials":null,"last_name":"Tanosaki","page_name":"RyujiTanosaki","domain_name":"independent","created_at":"2016-07-07T00:15:48.786-07:00","display_name":"Ryuji Tanosaki","url":"https://independent.academia.edu/RyujiTanosaki"},"attachments":[],"research_interests":[{"id":1867662,"name":"Hematopoietic Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Cell_Transplantation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798480"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798480/A_case_of_post_transplant_adult_T_cell_leukemia_lymphoma_presenting_myelopathy_similar_to_but_distinct_from_human_T_cell_leukemia_virus_type_I_HTLV_I_associated_myelopathy"><img alt="Research paper thumbnail of A case of post-transplant adult T-cell leukemia/lymphoma presenting myelopathy similar to but distinct from human T-cell leukemia virus type I (HTLV- I)-associated myelopathy" class="work-thumbnail" src="https://attachments.academia-assets.com/47072708/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798480/A_case_of_post_transplant_adult_T_cell_leukemia_lymphoma_presenting_myelopathy_similar_to_but_distinct_from_human_T_cell_leukemia_virus_type_I_HTLV_I_associated_myelopathy">A case of post-transplant adult T-cell leukemia/lymphoma presenting myelopathy similar to but distinct from human T-cell leukemia virus type I (HTLV- I)-associated myelopathy</a></div><div class="wp-workCard_item"><span>SpringerPlus</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="850fa6e26cde40da85a66a461598f5b7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47072708,"asset_id":26798480,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47072708/download_file?st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798480"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798480"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798480; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798480]").text(description); $(".js-view-count[data-work-id=26798480]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798480; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798480']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798480, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "850fa6e26cde40da85a66a461598f5b7" } } $('.js-work-strip[data-work-id=26798480]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798480,"title":"A case of post-transplant adult T-cell leukemia/lymphoma presenting myelopathy similar to but distinct from human T-cell leukemia virus type I (HTLV- I)-associated myelopathy","translated_title":"","metadata":{"ai_title_tag":"Post-Transplant ATL in Myelopathy: Distinct from HTLV-I","grobid_abstract":"Adult T-cell leukemia/lymphoma (ATL) responds poorly to conventional chemotherapy, but allogeneic stem cell transplantation (allo-SCT) may improve disease prognosis. Herein, we report a female patient with human T-cell leukemia virus type I (HTLV-I)-associated myelopathy (HAM)-like myelopathy following allo-SCT for ATL. Case report: She developed crural paresis 14 months after allo-SCT. Initially, she was diagnosed with central nervous system (CNS) relapse of ATL and treated with intrathecal injection and whole brain and spine irradiation. Her symptoms recurred 5 months later, when a cerebrospinal fluid (CSF) specimen showed increased CD4 + CXCR3 + CCR4+ cell numbers and levels of neopterin and CXCL10 (IP-10). Discussion: These results suggest the possible involvement of a certain immunological mechanism such as HAM in her symptoms, irrespective of the lack of anti-HTLV-I antibody in her CSF. Because a definitive diagnosis of CNS manifestation of ATL is sometimes difficult, multi-modal laboratory data are required for differential diagnosis.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"SpringerPlus","grobid_abstract_attachment_id":47072708},"translated_abstract":null,"internal_url":"https://www.academia.edu/26798480/A_case_of_post_transplant_adult_T_cell_leukemia_lymphoma_presenting_myelopathy_similar_to_but_distinct_from_human_T_cell_leukemia_virus_type_I_HTLV_I_associated_myelopathy","translated_internal_url":"","created_at":"2016-07-07T00:18:33.455-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50796887,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22150166,"work_id":26798480,"tagging_user_id":50796887,"tagged_user_id":50804220,"co_author_invite_id":4944598,"email":"a***o@ims.u-tokyo.ac.jp","display_order":0,"name":"Arinobu Tojo","title":"A case of 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798478/Cost_and_effectiveness_of_reduced_intensity_and_conventional_allogeneic_hematopoietic_stem_cell_transplantation_for_acute_myelogenous_leukemia_and_myelodysplastic_syndrome"><img alt="Research paper thumbnail of Cost and effectiveness of reduced-intensity and conventional allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndrome" class="work-thumbnail" src="https://attachments.academia-assets.com/47072712/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798478/Cost_and_effectiveness_of_reduced_intensity_and_conventional_allogeneic_hematopoietic_stem_cell_transplantation_for_acute_myelogenous_leukemia_and_myelodysplastic_syndrome">Cost and effectiveness of reduced-intensity and conventional allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndrome</a></div><div class="wp-workCard_item"><span>Supportive Care in Cancer</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="77f1920bd17589e3884e6e5e662d73a5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47072712,"asset_id":26798478,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47072712/download_file?st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa 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Transplant","grobid_abstract":"Goals of work Allogeneic stem cell transplantation with a reduced-intensity regimen (RIST) has been evaluated mostly in terms of its clinical benefit, and the pharmacoeconomic aspects of this procedure remain unclear. We compared the cost and effectiveness of RIST with those of stem cell transplantation using a conventional myeloablative regimen (CST). Patients and methods Fifty consecutive patients who underwent transplantation for myeloid malignancy were included. Life years and medical costs during the entire treatment course for up to 2 years after transplantation were evaluated, and cost-effectiveness was assessed from the payer's perspective. Main results Of these 50 cases, 35 were treated with CST and 15 were treated with RIST. The mean survival time was 1.5 years in CST and 1.2 years in RIST, while the mean total cost per patient within the first 2 years was $29,630 for CST and $29,466 for RIST, with no significant difference. The duration of total hospitalization was shorter in RIST than in CST; then, the cost for hospitalization represented a lower proportion of the total cost in RIST (49% of total cost) than in CST (63%). In contrast, the cost related to the conditioning regimen was significantly higher in RIST than in CST. Conclusions This result suggests that the increased cost of the conditioning regimen offsets the reduced cost of hospitalization in RIST. Although some differences were observed in the details of the cost, the total cost and mean survival were comparable between CST and RIST, and this result was confirmed by a probabilistic sensitivity analysis.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Supportive Care in 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class="work-thumbnail" src="https://attachments.academia-assets.com/47072710/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798477/The_Role_of_PGE_2_in_the_Differentiation_of_Dendritic_Cells_How_Do_Dendritic_Cells_Influence_T_Cell_Polarization_and_Chemokine_Receptor_Expression">The Role of PGE 2 in the Differentiation of Dendritic Cells: How Do Dendritic Cells Influence T-Cell Polarization and Chemokine Receptor Expression?</a></div><div class="wp-workCard_item"><span>Stem Cells</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="15dbe918a0eabd4c00cec4eefe96f4cf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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T-cell polarization, and expression of chemokine receptors was evaluated in human cells. Immature DCs were generated from peripheral blood CD14 + cells using a combination of GM-CSF and interleukin-4 (IL-4) with or without PGE 2 . On day 6, maturation of DCs was induced by the addition of tumor necrosis factor alpha with or without PGE 2 . DCs harvested on day 6 (immature DCs) or day 9 (mature DCs) were examined using functional assays. In the presence of PGE 2 , immature and mature DCs showed, phenotypically, a lower expression of CD1a and, functionally, a higher allostimulatory capacity at a high DC/T-cell ratio than control cells cultured in the absence of PGE 2 . DCs cultured in the presence of PGE 2 induced the differentiation of naïve T cells toward a helper T-cell type 1 (Th1) response, which was independent of IL-12 secretion in the basal state despite a slightly lower interferon gamma secretion compared with control cells. However, the function of cytotoxicity-stimulating autologous T cells was not augmented by the addition of PGE 2 . Immature DCs expressed the inflammatory chemokine receptors, CCR1 and CXCR4, but not CCR6, regardless of the presence or absence of PGE 2 . Mature DCs expressed CCR7 equally, measured using a migration test and the measurement of calcium flux with macrophage inflammatory protein-3β and reverse transcription-polymerase chain reaction assay in all of the groups. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20734052"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20734052/Freeze_Thawing_Procedures_Have_No_Influence_on_the_Phenotypic_and_Functional_Development_of_Dendritic_Cells_Generated_from_Peripheral_Blood_CD14_Monocytes"><img alt="Research paper thumbnail of Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20734052/Freeze_Thawing_Procedures_Have_No_Influence_on_the_Phenotypic_and_Functional_Development_of_Dendritic_Cells_Generated_from_Peripheral_Blood_CD14_Monocytes">Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/TadaoKakizoe">Tadao Kakizoe</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RyujiTanosaki">Ryuji Tanosaki</a></span></div><div class="wp-workCard_item"><span>Journal of Immunotherapy</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Little is known about the potential influence of cryopreservation on the biologic activities of d...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Little is known about the potential influence of cryopreservation on the biologic activities of dendritic cells (DCs). In this study, we examined the effects of freeze-thawing on the phenotypic and functional development of human DCs obtained from granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood CD14+ cells. CD14+ cells were cultured, immediately or after freeze-thawing, with granulocyte-macrophage CSF and interleukin-4 for 9 days, and then with added tumor necrosis factor-alpha for another 3 days. For both fresh and freeze-thawed monocytes, immature DCs harvested on day 6 and mature DCs harvested on day 9 of culture were examined under the same conditions. Cells were compared with regard to their 1) capacities for antigen endocytosis and chemotactic migration (immature DCs), and 2) allogeneic mixed lymphocyte reaction and antigen-specific cytotoxic T lymphocyte responses (mature DCs). Freeze-thawing did not affect the viability or subsequent maturation of DCs at any stage of development. Furthermore, essentially no difference was observed in phenotype or function between cells generated from fresh or cryopreserved/thawed cells. Although this study design was limited with the use of fetal bovine serum, the observation still suggests that freeze-thawing does not affect viability, phenotype, subsequent maturation, or functions of DCs at any stage of maturation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20734052"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20734052"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20734052; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20734052]").text(description); $(".js-view-count[data-work-id=20734052]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20734052; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20734052']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20734052, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20734052]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20734052,"title":"Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes","translated_title":"","metadata":{"abstract":"Little is known about the potential influence of cryopreservation on the biologic activities of dendritic cells (DCs). In this study, we examined the effects of freeze-thawing on the phenotypic and functional development of human DCs obtained from granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood CD14+ cells. CD14+ cells were cultured, immediately or after freeze-thawing, with granulocyte-macrophage CSF and interleukin-4 for 9 days, and then with added tumor necrosis factor-alpha for another 3 days. For both fresh and freeze-thawed monocytes, immature DCs harvested on day 6 and mature DCs harvested on day 9 of culture were examined under the same conditions. Cells were compared with regard to their 1) capacities for antigen endocytosis and chemotactic migration (immature DCs), and 2) allogeneic mixed lymphocyte reaction and antigen-specific cytotoxic T lymphocyte responses (mature DCs). Freeze-thawing did not affect the viability or subsequent maturation of DCs at any stage of development. Furthermore, essentially no difference was observed in phenotype or function between cells generated from fresh or cryopreserved/thawed cells. Although this study design was limited with the use of fetal bovine serum, the observation still suggests that freeze-thawing does not affect viability, phenotype, subsequent maturation, or functions of DCs at any stage of maturation.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Journal of Immunotherapy"},"translated_abstract":"Little is known about the potential influence of cryopreservation on the biologic activities of dendritic cells (DCs). In this study, we examined the effects of freeze-thawing on the phenotypic and functional development of human DCs obtained from granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood CD14+ cells. CD14+ cells were cultured, immediately or after freeze-thawing, with granulocyte-macrophage CSF and interleukin-4 for 9 days, and then with added tumor necrosis factor-alpha for another 3 days. For both fresh and freeze-thawed monocytes, immature DCs harvested on day 6 and mature DCs harvested on day 9 of culture were examined under the same conditions. Cells were compared with regard to their 1) capacities for antigen endocytosis and chemotactic migration (immature DCs), and 2) allogeneic mixed lymphocyte reaction and antigen-specific cytotoxic T lymphocyte responses (mature DCs). Freeze-thawing did not affect the viability or subsequent maturation of DCs at any stage of development. Furthermore, essentially no difference was observed in phenotype or function between cells generated from fresh or cryopreserved/thawed cells. Although this study design was limited with the use of fetal bovine serum, the observation still suggests that freeze-thawing does not affect viability, phenotype, subsequent maturation, or functions of DCs at any stage of maturation.","internal_url":"https://www.academia.edu/20734052/Freeze_Thawing_Procedures_Have_No_Influence_on_the_Phenotypic_and_Functional_Development_of_Dendritic_Cells_Generated_from_Peripheral_Blood_CD14_Monocytes","translated_internal_url":"","created_at":"2016-01-24T19:15:27.951-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42031465,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":13624063,"work_id":20734052,"tagging_user_id":42031465,"tagged_user_id":null,"co_author_invite_id":1890015,"email":"s***u@nips.ac.jp","display_order":0,"name":"Shigeru Saito","title":"Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes"},{"id":13624212,"work_id":20734052,"tagging_user_id":42031465,"tagged_user_id":null,"co_author_invite_id":3187129,"email":"h***i@red.umds.ac.jp","display_order":4194304,"name":"Hiroyuki Kawai","title":"Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes"},{"id":13624227,"work_id":20734052,"tagging_user_id":42031465,"tagged_user_id":50796887,"co_author_invite_id":3187135,"email":"r***k@ncc.go.jp","display_order":6291456,"name":"Ryuji Tanosaki","title":"Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes"}],"downloadable_attachments":[],"slug":"Freeze_Thawing_Procedures_Have_No_Influence_on_the_Phenotypic_and_Functional_Development_of_Dendritic_Cells_Generated_from_Peripheral_Blood_CD14_Monocytes","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42031465,"first_name":"Tadao","middle_initials":null,"last_name":"Kakizoe","page_name":"TadaoKakizoe","domain_name":"independent","created_at":"2016-01-24T19:14:37.893-08:00","display_name":"Tadao Kakizoe","url":"https://independent.academia.edu/TadaoKakizoe"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":19295,"name":"Cryopreservation","url":"https://www.academia.edu/Documents/in/Cryopreservation"},{"id":35539,"name":"Dendritic Cells","url":"https://www.academia.edu/Documents/in/Dendritic_Cells"},{"id":126863,"name":"Immunotherapy","url":"https://www.academia.edu/Documents/in/Immunotherapy"},{"id":153279,"name":"Dendritic cell","url":"https://www.academia.edu/Documents/in/Dendritic_cell"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":402972,"name":"Monocytes","url":"https://www.academia.edu/Documents/in/Monocytes"},{"id":957359,"name":"Culture Media","url":"https://www.academia.edu/Documents/in/Culture_Media"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798476"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798476/Ex_vivo_manipulation_of_umbilical_cord_blood_derived_hematopoietic_stem_progenitor_cells_with_recombinant_human_stem_cell_factor_can_up_regulate_levels_of_homing_essential_molecules_to_increase_their_transmigratory_potential"><img alt="Research paper thumbnail of Ex vivo manipulation of umbilical cord blood-derived hematopoietic stem/progenitor cells with recombinant human stem cell factor can up-regulate levels of homing-essential molecules to increase their transmigratory potential" class="work-thumbnail" src="https://attachments.academia-assets.com/47072709/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798476/Ex_vivo_manipulation_of_umbilical_cord_blood_derived_hematopoietic_stem_progenitor_cells_with_recombinant_human_stem_cell_factor_can_up_regulate_levels_of_homing_essential_molecules_to_increase_their_transmigratory_potential">Ex vivo manipulation of umbilical cord blood-derived hematopoietic stem/progenitor cells with recombinant human stem cell factor can up-regulate levels of homing-essential molecules to increase their transmigratory potential</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RyujiTanosaki">Ryuji Tanosaki</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ArinobuTojo">Arinobu Tojo</a></span></div><div class="wp-workCard_item"><span>Experimental Hematology</span><span>, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="89778cdbe08a52e710d58dd37f622a7c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47072709,"asset_id":26798476,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47072709/download_file?st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798476"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798476"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798476; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798476]").text(description); $(".js-view-count[data-work-id=26798476]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798476; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798476']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798476, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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The cause of delayed hematopoietic reconstitution after umbilical cord blood transplantation (UCBT) remains controversial. We hypothesized that hematopoietic stem/ progenitor cells (HS/PCs) from UCB have some defects of the homing-related molecules responsible for their slow engraftment. Materials and Methods. A homing-related molecule repertoire expressed on HS/PCs from fresh and cryopreserved UCB, mobilized peripheral blood (mPB), and bone marrow (BM) were compared using sensitive, four-color fluorescence-activated cell sorting analysis. Purified CD34 ϩ cells were subjected to ex vivo transmigration through double-coated transwell filter inserts, and an in vivo homing assay was performed in xenotransplanted NOD/SCID mice. Results. UCB-derived CD34 bright cells expressed significantly lower levels of CD49e, CD49f, and CXCR-4 than their mPB and BM counterparts. CD34 ϩ cells from UCB (and BM) exhibited significantly lower ex vivo transmigration than those from mPB, which were largely blocked by neutralizing antibodies to CD49e or CD49f. Recombinant human tumor necrosis factor-a treatment enhanced ex vivo transmigration of CD34 ϩ cells from UCB and BM by inducing expression of the matrix metalloproteinases MMP-2/MMP-9. Short-term treatment of UCBderived CD34 ϩ cells with rHu-stem cell factor (rHuSCF) up-regulated levels of the homingrelated molecules with their increased ex vivo transmigratory and in vivo homing potential.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Experimental 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798475"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798475/Treatment_of_advanced_myelodysplastic_syndrome_with_a_regimen_including_recombinant_human_granulocyte_colony_stimulating_factor_preceding_allogeneic_bone_marrow_transplantation"><img alt="Research paper thumbnail of Treatment of advanced myelodysplastic syndrome with a regimen including recombinant human granulocyte colony-stimulating factor preceding allogeneic bone marrow transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/47072711/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798475/Treatment_of_advanced_myelodysplastic_syndrome_with_a_regimen_including_recombinant_human_granulocyte_colony_stimulating_factor_preceding_allogeneic_bone_marrow_transplantation">Treatment of advanced myelodysplastic syndrome with a regimen including recombinant human granulocyte colony-stimulating factor preceding allogeneic bone marrow transplantation</a></div><div class="wp-workCard_item"><span>British Journal of Haematology</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9c5bbfcb80ca4088ca19628f45e667a4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47072711,"asset_id":26798475,"asset_type":"Work","button_location":"profile"}" 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syndrome using cytosine arabinoside and total body irradiation, followed by allogeneic marrow transplantation from HLA-identical sibling donors. Granulocyte colony-stimulating factor (G-CSF) was added to the preparative regimen to selectively increase chemosensitivity of leukaemic cells and to improve transplant outcome. No regimen-related deaths occurred, and no side-effects related to the addition of G-CSF were observed except for transient mild bone pain. At a median follow-up time of 39 months the projected 5-year disease-free survival and 5-year overall survival were 67·7% and 75·5%, respectively, with only one case showing cytogenetic relapse. The preparative regimen including G-CSF is feasible, and preliminary results seem to be encouraging. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798474"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798474/Outcomes_of_patients_with_acute_leukaemia_who_relapsed_after_reduced_intensity_stem_cell_transplantation_from_HLA_identical_or_one_antigen_mismatched_related_donors"><img alt="Research paper thumbnail of Outcomes of patients with acute leukaemia who relapsed after reduced-intensity stem cell transplantation from HLA-identical or one antigen-mismatched related donors" class="work-thumbnail" src="https://attachments.academia-assets.com/47072704/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798474/Outcomes_of_patients_with_acute_leukaemia_who_relapsed_after_reduced_intensity_stem_cell_transplantation_from_HLA_identical_or_one_antigen_mismatched_related_donors">Outcomes of patients with acute leukaemia who relapsed after reduced-intensity stem cell transplantation from HLA-identical or one antigen-mismatched related donors</a></div><div class="wp-workCard_item"><span>British Journal of Haematology</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2845e3fafc7f0c407e60a1e20a1f521d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47072704,"asset_id":26798474,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47072704/download_file?st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798474"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798474"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798474; 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href="https://www.academia.edu/26798473/Decreased_insulin_secretion_in_patients_receiving_tacrolimus_as_GVHD_prophylaxis_after_allogeneic_hematopoietic_SCT"><img alt="Research paper thumbnail of Decreased insulin secretion in patients receiving tacrolimus as GVHD prophylaxis after allogeneic hematopoietic SCT" class="work-thumbnail" src="https://attachments.academia-assets.com/47072705/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798473/Decreased_insulin_secretion_in_patients_receiving_tacrolimus_as_GVHD_prophylaxis_after_allogeneic_hematopoietic_SCT">Decreased insulin secretion in patients receiving tacrolimus as GVHD prophylaxis after allogeneic hematopoietic SCT</a></div><div class="wp-workCard_item"><span>Bone Marrow Transplantation</span><span>, 2010</span></div><div 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{"id":26798473,"title":"Decreased insulin secretion in patients receiving tacrolimus as GVHD prophylaxis after allogeneic hematopoietic SCT","translated_title":"","metadata":{"grobid_abstract":"Fasting glucose level (mg per 100 ml) Pretransplant 87 (80-129) ] P ¼ 0.08 89 (79-154) ] P ¼ 0.55 Posttransplant 95 (79-129) 91 (80-116) Immunoreactive insulin level (mU/ml) Pretransplant 6.1 (1.6-17.3) ] P ¼ 0.60 6.6 (2.9-13.5) ] P ¼ 0.25 Posttransplant 6.5 (1.5-18.0) 5.3 (2.4-10.1) HOMA-IR Pretransplant 1.4 (0.3-4.6) ] P ¼ 0.75 1.4 (0.6-5.13) ] P ¼ 0.40 Posttransplant 1.5 (0.3-4.2) 1.3 (0.5-2.2) HOMA-b Pretransplant 90.9 (30.3-193.7) ] P ¼ 0.04 65.4 (38.7-160.0) ] P ¼ 0.43 Posttransplant 69.9 (15.8-202.5) 61.7 (28.5-180.0) Abbreviations: HOMA ¼ homeostasis model assessment; IR ¼ insulin resistance.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Bone Marrow 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transplantation for adult T-cell leukemia: a retrospective cohort study" class="work-thumbnail" src="https://attachments.academia-assets.com/47072706/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798472/Impact_of_graft_versus_host_disease_on_outcomes_after_allogeneic_hematopoietic_cell_transplantation_for_adult_T_cell_leukemia_a_retrospective_cohort_study">Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study</a></div><div class="wp-workCard_item"><span>Blood</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8b6fd653f40e0e54b7f81c53a0149b7c" class="wp-workCard--action" 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study","translated_title":"","metadata":{"grobid_abstract":", raising the question about the role of graft-versusleukemia effect against ATL. In this study, we retrospectively analyzed the effects of acute and chronic graft-versus-host disease (GVHD) on overall survival, diseaseassociated mortality, and treatmentrelated mortality among 294 ATL patients who received allogeneic HCT and survived at least 30 days posttransplant with sustained engraftment. Multivariate anal-yses treating the occurrence of GVHD as a time-varying covariate demonstrated that the development of grade 1-2 acute GVHD was significantly associated with higher overall survival (hazard ratio [HR] for death, 0.65; P ‫؍‬ .018) compared with the absence of acute GVHD. Occurrence of either grade 1-2 or grade 3-4 acute GVHD was associated with lower diseaseassociated mortality compared with the absence of acute GVHD, whereas grade 3-4 acute GVHD was associated with a higher risk for treatment-related mortality (HR, 3.50; P \u003c .001). The development of extensive chronic GVHD was associated with higher treatment-related mortality (HR, 2.75; P ‫؍‬ .006) compared with the absence of chronic GVHD. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="5479293" id="papers"><div class="js-work-strip profile--work_container" data-work-id="26798485"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798485/Eltrombopag_for_treatment_of_thrombocytopenia_after_allogeneic_hematopoietic_cell_transplantation"><img alt="Research paper thumbnail of Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798485/Eltrombopag_for_treatment_of_thrombocytopenia_after_allogeneic_hematopoietic_cell_transplantation">Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation</a></div><div class="wp-workCard_item"><span>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</span><span>, Jan 16, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Persistent thrombocytopenia is a common complication after allogeneic hematopoietic cell transpla...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Persistent thrombocytopenia is a common complication after allogeneic hematopoietic cell transplantation (HCT). Eltrombopag is an oral thrombopoietin receptor agonist whose efficacy against persistent thrombocytopenia after allogeneic HCT has not been well characterized. This retrospective study evaluated the safety and efficacy of eltrombopag in 12 consecutive patients with persistent thrombocytopenia after allogeneic HCT. Eltrombopag was started at 12.5 mg once daily and the dose was increased by 12.5 mg daily every week until platelet counts exceeded 50,000/μL. Five patients had prolonged isolated thrombocytopenia (PIT) and 7 patients had secondary failure of platelet recovery (SFPR). The cumulative incidence rate of successful platelet recovery to ≥50,000/μL without transfusion support was 60% in PIT patients and 71% in SFPR patients. No patients discontinued the drug because of adverse events or intolerability. Notably, the rate of platelet recovery was higher (100% versus 58%;...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798485"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798485"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798485; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798485]").text(description); $(".js-view-count[data-work-id=26798485]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798485; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798485']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798485, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26798485]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798485,"title":"Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation","translated_title":"","metadata":{"abstract":"Persistent thrombocytopenia is a common complication after allogeneic hematopoietic cell transplantation (HCT). Eltrombopag is an oral thrombopoietin receptor agonist whose efficacy against persistent thrombocytopenia after allogeneic HCT has not been well characterized. This retrospective study evaluated the safety and efficacy of eltrombopag in 12 consecutive patients with persistent thrombocytopenia after allogeneic HCT. Eltrombopag was started at 12.5 mg once daily and the dose was increased by 12.5 mg daily every week until platelet counts exceeded 50,000/μL. Five patients had prolonged isolated thrombocytopenia (PIT) and 7 patients had secondary failure of platelet recovery (SFPR). The cumulative incidence rate of successful platelet recovery to ≥50,000/μL without transfusion support was 60% in PIT patients and 71% in SFPR patients. No patients discontinued the drug because of adverse events or intolerability. Notably, the rate of platelet recovery was higher (100% versus 58%;...","publication_date":{"day":16,"month":1,"year":2016,"errors":{}},"publication_name":"Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation"},"translated_abstract":"Persistent thrombocytopenia is a common complication after allogeneic hematopoietic cell transplantation (HCT). Eltrombopag is an oral thrombopoietin receptor agonist whose efficacy against persistent thrombocytopenia after allogeneic HCT has not been well characterized. This retrospective study evaluated the safety and efficacy of eltrombopag in 12 consecutive patients with persistent thrombocytopenia after allogeneic HCT. Eltrombopag was started at 12.5 mg once daily and the dose was increased by 12.5 mg daily every week until platelet counts exceeded 50,000/μL. Five patients had prolonged isolated thrombocytopenia (PIT) and 7 patients had secondary failure of platelet recovery (SFPR). 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Notably, the rate of platelet recovery was higher (100% versus 58%;...","internal_url":"https://www.academia.edu/26798485/Eltrombopag_for_treatment_of_thrombocytopenia_after_allogeneic_hematopoietic_cell_transplantation","translated_internal_url":"","created_at":"2016-07-07T00:18:34.645-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50796887,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22150195,"work_id":26798485,"tagging_user_id":50796887,"tagged_user_id":null,"co_author_invite_id":4944612,"email":"t***0@gmail.com","display_order":0,"name":"Tetsuya Fukuda","title":"Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation"}],"downloadable_attachments":[],"slug":"Eltrombopag_for_treatment_of_thrombocytopenia_after_allogeneic_hematopoietic_cell_transplantation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50796887,"first_name":"Ryuji","middle_initials":null,"last_name":"Tanosaki","page_name":"RyujiTanosaki","domain_name":"independent","created_at":"2016-07-07T00:15:48.786-07:00","display_name":"Ryuji Tanosaki","url":"https://independent.academia.edu/RyujiTanosaki"},"attachments":[],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); 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Adults with acute leukaemia who relapsed after allo-SCT had a median survival of 3-4 months if no treatment was given . Approaches to treating patients in relapse after allo-SCT include rapid tapering of immunosuppressive agents, donor lymphocyte infusion (DLI), re-induction chemotherapy and second transplantation. Standard chemotherapy sometimes results in complete remission (CR), but long-term disease-free survival (DFS) is unlikely, because of regimen-related toxicity (RRT) and recurrence . Although a second allograft produces sustained molecular remission in a proportion of patients, transplant-related mortality (TRM) is high with 100-d mortality rates of 25-50% and a DFS of 10% . Poor prognostic factors after second allo-SCT include an interval between the procedures of \u003c1 year, resistance to re-induction chemotherapy, older age and poor performance status . 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href="https://www.academia.edu/26798483/Granisetron_in_the_prevention_of_vomiting_induced_by_conditioning_for_stem_cell_transplantation_A_prospective_randomized_study"><img alt="Research paper thumbnail of Granisetron in the prevention of vomiting induced by conditioning for stem cell transplantation: A prospective randomized study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798483/Granisetron_in_the_prevention_of_vomiting_induced_by_conditioning_for_stem_cell_transplantation_A_prospective_randomized_study">Granisetron in the prevention of vomiting induced by conditioning for stem cell transplantation: A prospective randomized study</a></div><div class="wp-workCard_item"><span>Bone Marrow Transplantation</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We conducted a prospective randomized study to compare granisetron, a 5-hydroxytryptamine-3 recep...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We conducted a prospective randomized study to compare granisetron, a 5-hydroxytryptamine-3 receptor antagonist with standard anti-emetics (control group) consisting mainly of metoclopramide, in the prophylaxis of emesis induced by conditioning prior to stem cell transplantation. Fifty-eight patients were evaluable for analysis. The number of emetic episodes expressed in terms of patient-days was significantly lower in the granisetron group than in the control group (P &amp;lt; 0.001). During the first 24 h of conditioning, 27 of the 31 patients (87.1%) in the granisetron group achieved control of emesis with less than three emetic episodes (major &amp;lt; or = ) a day compared with 37.0% in the control group (P &amp;lt; 0.001). The same degree of emesis control was maintained throughout the conditioning period in 51.% of patients in the granisetron group compared with 0% in the control group (P &amp;lt; 0.001). Adverse reactions were observed in 11.4% of patients in the granisetron group and in 25.9% in the control group. None of the events were serious. Based on these data, we conclude that granisetron is superior to standard antiemetics in protecting against the vomiting induced by conditioning for stem cell transplantation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798483"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798483"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798483; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798483]").text(description); $(".js-view-count[data-work-id=26798483]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798483; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798483']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798483, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26798483]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798483,"title":"Granisetron in the prevention of vomiting induced by conditioning for stem cell transplantation: A prospective randomized study","translated_title":"","metadata":{"abstract":"We conducted a prospective randomized study to compare granisetron, a 5-hydroxytryptamine-3 receptor antagonist with standard anti-emetics (control group) consisting mainly of metoclopramide, in the prophylaxis of emesis induced by conditioning prior to stem cell transplantation. Fifty-eight patients were evaluable for analysis. The number of emetic episodes expressed in terms of patient-days was significantly lower in the granisetron group than in the control group (P \u0026amp;lt; 0.001). During the first 24 h of conditioning, 27 of the 31 patients (87.1%) in the granisetron group achieved control of emesis with less than three emetic episodes (major \u0026amp;lt; or = ) a day compared with 37.0% in the control group (P \u0026amp;lt; 0.001). The same degree of emesis control was maintained throughout the conditioning period in 51.% of patients in the granisetron group compared with 0% in the control group (P \u0026amp;lt; 0.001). Adverse reactions were observed in 11.4% of patients in the granisetron group and in 25.9% in the control group. None of the events were serious. Based on these data, we conclude that granisetron is superior to standard antiemetics in protecting against the vomiting induced by conditioning for stem cell transplantation.","publication_name":"Bone Marrow Transplantation"},"translated_abstract":"We conducted a prospective randomized study to compare granisetron, a 5-hydroxytryptamine-3 receptor antagonist with standard anti-emetics (control group) consisting mainly of metoclopramide, in the prophylaxis of emesis induced by conditioning prior to stem cell transplantation. Fifty-eight patients were evaluable for analysis. The number of emetic episodes expressed in terms of patient-days was significantly lower in the granisetron group than in the control group (P \u0026amp;lt; 0.001). During the first 24 h of conditioning, 27 of the 31 patients (87.1%) in the granisetron group achieved control of emesis with less than three emetic episodes (major \u0026amp;lt; or = ) a day compared with 37.0% in the control group (P \u0026amp;lt; 0.001). The same degree of emesis control was maintained throughout the conditioning period in 51.% of patients in the granisetron group compared with 0% in the control group (P \u0026amp;lt; 0.001). Adverse reactions were observed in 11.4% of patients in the granisetron group and in 25.9% in the control group. None of the events were serious. Based on these data, we conclude that granisetron is superior to standard antiemetics in protecting against the vomiting induced by conditioning for stem cell transplantation.","internal_url":"https://www.academia.edu/26798483/Granisetron_in_the_prevention_of_vomiting_induced_by_conditioning_for_stem_cell_transplantation_A_prospective_randomized_study","translated_internal_url":"","created_at":"2016-07-07T00:18:34.209-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50796887,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Granisetron_in_the_prevention_of_vomiting_induced_by_conditioning_for_stem_cell_transplantation_A_prospective_randomized_study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50796887,"first_name":"Ryuji","middle_initials":null,"last_name":"Tanosaki","page_name":"RyujiTanosaki","domain_name":"independent","created_at":"2016-07-07T00:15:48.786-07:00","display_name":"Ryuji 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href="https://www.academia.edu/20734080/Allogeneic_hematopoietic_stem_cell_transplantation_with_a_reduced_intensity_conditioning_regimen_for_treatment_of_metastatic_renal_cell_carcinoma_single_institution_experience_with_a_minimum_1_year_follow_up"><img alt="Research paper thumbnail of Allogeneic hematopoietic stem cell transplantation with a reduced-intensity conditioning regimen for treatment of metastatic renal cell carcinoma: single institution experience with a minimum 1-year follow-up" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20734080/Allogeneic_hematopoietic_stem_cell_transplantation_with_a_reduced_intensity_conditioning_regimen_for_treatment_of_metastatic_renal_cell_carcinoma_single_institution_experience_with_a_minimum_1_year_follow_up">Allogeneic hematopoietic stem cell transplantation with a reduced-intensity conditioning regimen for treatment of metastatic renal cell carcinoma: single institution experience with a minimum 1-year follow-up</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/TadaoKakizoe">Tadao Kakizoe</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RyujiTanosaki">Ryuji Tanosaki</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/TohruNakagawa">Tohru Nakagawa</a></span></div><div class="wp-workCard_item"><span>Experimental Hematology</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ObjectiveThe aim of this study was to evaluate the safety and efficacy of allogeneic hematopoieti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ObjectiveThe aim of this study was to evaluate the safety and efficacy of allogeneic hematopoietic stem cell transplantation with a reduced-intensity conditioning regimen (RIST) for interferon-α–refractory metastatic renal cell carcinoma (RCC).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span 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profile--work_container" data-work-id="26798482"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798482/Balance_between_acute_graft_versus_host_disease_and_graft_versus_tumor_effect_after_reduced_intensity_transplantation_for_metastatic_renal_cell_carcinoma"><img alt="Research paper thumbnail of Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798482/Balance_between_acute_graft_versus_host_disease_and_graft_versus_tumor_effect_after_reduced_intensity_transplantation_for_metastatic_renal_cell_carcinoma">Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma</a></div><div class="wp-workCard_item"><span>The hematology journal : the official journal of the European Haematology Association / EHA</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for met...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798482"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798482"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798482; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798482]").text(description); $(".js-view-count[data-work-id=26798482]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798482; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798482']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798482, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26798482]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798482,"title":"Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma","translated_title":"","metadata":{"abstract":"We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"The hematology journal : the official journal of the European Haematology Association / EHA"},"translated_abstract":"We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.","internal_url":"https://www.academia.edu/26798482/Balance_between_acute_graft_versus_host_disease_and_graft_versus_tumor_effect_after_reduced_intensity_transplantation_for_metastatic_renal_cell_carcinoma","translated_internal_url":"","created_at":"2016-07-07T00:18:33.756-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50796887,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Balance_between_acute_graft_versus_host_disease_and_graft_versus_tumor_effect_after_reduced_intensity_transplantation_for_metastatic_renal_cell_carcinoma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50796887,"first_name":"Ryuji","middle_initials":null,"last_name":"Tanosaki","page_name":"RyujiTanosaki","domain_name":"independent","created_at":"2016-07-07T00:15:48.786-07:00","display_name":"Ryuji Tanosaki","url":"https://independent.academia.edu/RyujiTanosaki"},"attachments":[],"research_interests":[{"id":37864,"name":"Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Stem_Cell_Transplantation"},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease"},{"id":105308,"name":"Renal cell Carcinoma","url":"https://www.academia.edu/Documents/in/Renal_cell_Carcinoma"},{"id":2471455,"name":"Acute Disease","url":"https://www.academia.edu/Documents/in/Acute_Disease"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798481"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798481/Long_term_follow_up_system_after_allogeneic_hematopoietic_stem_cell_transplantation_a_single_center_feasibility_study"><img alt="Research paper thumbnail of Long-term follow-up system after allogeneic hematopoietic stem cell transplantation: a single-center feasibility study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798481/Long_term_follow_up_system_after_allogeneic_hematopoietic_stem_cell_transplantation_a_single_center_feasibility_study">Long-term follow-up system after allogeneic hematopoietic stem cell transplantation: a single-center feasibility study</a></div><div class="wp-workCard_item"><span>Journal of Hematopoietic Cell Transplantation</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Long-term survivors after allogeneic hematopoietic cell transplantation (allo-HCT) are a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Long-term survivors after allogeneic hematopoietic cell transplantation (allo-HCT) are at risk for developing late complications. To assess the feasibility of long-term follow-up (LTFU) system for allo-HCT survivors, we performed a feasibility study at our center. Patients aged 20 or above who received their first allo-HCT at our center were prospectively enrolled. Patients who had recurrent malignancy were not eligible. LTFU visits were scheduled at 1, 3, 6 months and every 1 year after allo-HCT. Regular blood test, performance status, body weight, graft-versus-host disease, pulmonary function, chest X-ray, disease status, thyroid function, bone density and immune recovery were assessed at each visit. Quality of life (QOL) was also assessed using the FACT-BMT and SF-36. Forty-seven patients with a median age of 55 years and a median follow-up of 24 months (range, 3 months to 7 years) were enrolled during the 6-month study period. Proportions of patients who completed scheduled screening tests ranged from 64 to 100%, and 32% of the participants completed all the screening tests. Fifty-seven percent of participants returned the QOL questionnaires. In conclusion, the LTFU system was feasible at our center, although a more systematic ordering system and tools to capture specific problems after allo-HCT are warranted.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798481"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798481"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798481; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798481]").text(description); $(".js-view-count[data-work-id=26798481]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798481; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798481']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798481, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26798481]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798481,"title":"Long-term follow-up system after allogeneic hematopoietic stem cell transplantation: a single-center feasibility study","translated_title":"","metadata":{"abstract":"ABSTRACT Long-term survivors after allogeneic hematopoietic cell transplantation (allo-HCT) are at risk for developing late complications. To assess the feasibility of long-term follow-up (LTFU) system for allo-HCT survivors, we performed a feasibility study at our center. Patients aged 20 or above who received their first allo-HCT at our center were prospectively enrolled. Patients who had recurrent malignancy were not eligible. LTFU visits were scheduled at 1, 3, 6 months and every 1 year after allo-HCT. Regular blood test, performance status, body weight, graft-versus-host disease, pulmonary function, chest X-ray, disease status, thyroid function, bone density and immune recovery were assessed at each visit. Quality of life (QOL) was also assessed using the FACT-BMT and SF-36. Forty-seven patients with a median age of 55 years and a median follow-up of 24 months (range, 3 months to 7 years) were enrolled during the 6-month study period. Proportions of patients who completed scheduled screening tests ranged from 64 to 100%, and 32% of the participants completed all the screening tests. Fifty-seven percent of participants returned the QOL questionnaires. In conclusion, the LTFU system was feasible at our center, although a more systematic ordering system and tools to capture specific problems after allo-HCT are warranted.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of Hematopoietic Cell Transplantation"},"translated_abstract":"ABSTRACT Long-term survivors after allogeneic hematopoietic cell transplantation (allo-HCT) are at risk for developing late complications. To assess the feasibility of long-term follow-up (LTFU) system for allo-HCT survivors, we performed a feasibility study at our center. Patients aged 20 or above who received their first allo-HCT at our center were prospectively enrolled. Patients who had recurrent malignancy were not eligible. LTFU visits were scheduled at 1, 3, 6 months and every 1 year after allo-HCT. Regular blood test, performance status, body weight, graft-versus-host disease, pulmonary function, chest X-ray, disease status, thyroid function, bone density and immune recovery were assessed at each visit. Quality of life (QOL) was also assessed using the FACT-BMT and SF-36. Forty-seven patients with a median age of 55 years and a median follow-up of 24 months (range, 3 months to 7 years) were enrolled during the 6-month study period. Proportions of patients who completed scheduled screening tests ranged from 64 to 100%, and 32% of the participants completed all the screening tests. Fifty-seven percent of participants returned the QOL questionnaires. In conclusion, the LTFU system was feasible at our center, although a more systematic ordering system and tools to capture specific problems after allo-HCT are warranted.","internal_url":"https://www.academia.edu/26798481/Long_term_follow_up_system_after_allogeneic_hematopoietic_stem_cell_transplantation_a_single_center_feasibility_study","translated_internal_url":"","created_at":"2016-07-07T00:18:33.603-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50796887,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22150204,"work_id":26798481,"tagging_user_id":50796887,"tagged_user_id":null,"co_author_invite_id":4944612,"email":"t***0@gmail.com","display_order":0,"name":"Tetsuya Fukuda","title":"Long-term follow-up system after allogeneic hematopoietic stem cell transplantation: a single-center feasibility study"}],"downloadable_attachments":[],"slug":"Long_term_follow_up_system_after_allogeneic_hematopoietic_stem_cell_transplantation_a_single_center_feasibility_study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50796887,"first_name":"Ryuji","middle_initials":null,"last_name":"Tanosaki","page_name":"RyujiTanosaki","domain_name":"independent","created_at":"2016-07-07T00:15:48.786-07:00","display_name":"Ryuji Tanosaki","url":"https://independent.academia.edu/RyujiTanosaki"},"attachments":[],"research_interests":[{"id":1867662,"name":"Hematopoietic Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Cell_Transplantation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798480"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798480/A_case_of_post_transplant_adult_T_cell_leukemia_lymphoma_presenting_myelopathy_similar_to_but_distinct_from_human_T_cell_leukemia_virus_type_I_HTLV_I_associated_myelopathy"><img alt="Research paper thumbnail of A case of post-transplant adult T-cell leukemia/lymphoma presenting myelopathy similar to but distinct from human T-cell leukemia virus type I (HTLV- I)-associated myelopathy" class="work-thumbnail" src="https://attachments.academia-assets.com/47072708/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798480/A_case_of_post_transplant_adult_T_cell_leukemia_lymphoma_presenting_myelopathy_similar_to_but_distinct_from_human_T_cell_leukemia_virus_type_I_HTLV_I_associated_myelopathy">A case of post-transplant adult T-cell leukemia/lymphoma presenting myelopathy similar to but distinct from human T-cell leukemia virus type I (HTLV- I)-associated myelopathy</a></div><div class="wp-workCard_item"><span>SpringerPlus</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="850fa6e26cde40da85a66a461598f5b7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47072708,"asset_id":26798480,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47072708/download_file?st=MTczMjg5Mjk4NSw4LjIyMi4yMDguMTQ2&st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798480"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798480"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798480; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798480]").text(description); $(".js-view-count[data-work-id=26798480]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798480; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798480']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798480, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Herein, we report a female patient with human T-cell leukemia virus type I (HTLV-I)-associated myelopathy (HAM)-like myelopathy following allo-SCT for ATL. Case report: She developed crural paresis 14 months after allo-SCT. Initially, she was diagnosed with central nervous system (CNS) relapse of ATL and treated with intrathecal injection and whole brain and spine irradiation. Her symptoms recurred 5 months later, when a cerebrospinal fluid (CSF) specimen showed increased CD4 + CXCR3 + CCR4+ cell numbers and levels of neopterin and CXCL10 (IP-10). Discussion: These results suggest the possible involvement of a certain immunological mechanism such as HAM in her symptoms, irrespective of the lack of anti-HTLV-I antibody in her CSF. 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798479"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798479/Endoscopic_diagnosis_of_cytomegalovirus_gastritis_after_allogeneic_hematopoietic_stem_cell_transplantation"><img alt="Research paper thumbnail of Endoscopic diagnosis of cytomegalovirus gastritis after allogeneic hematopoietic stem cell transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/47072713/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798479/Endoscopic_diagnosis_of_cytomegalovirus_gastritis_after_allogeneic_hematopoietic_stem_cell_transplantation">Endoscopic diagnosis of cytomegalovirus gastritis after allogeneic hematopoietic stem cell transplantation</a></div><div class="wp-workCard_item"><span>World Journal of Gastroenterology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9df747c410bb391ef2627c8203b98896" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47072713,"asset_id":26798479,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47072713/download_file?st=MTczMjg5Mjk4NSw4LjIyMi4yMDguMTQ2&st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798478/Cost_and_effectiveness_of_reduced_intensity_and_conventional_allogeneic_hematopoietic_stem_cell_transplantation_for_acute_myelogenous_leukemia_and_myelodysplastic_syndrome"><img alt="Research paper thumbnail of Cost and effectiveness of reduced-intensity and conventional allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndrome" class="work-thumbnail" src="https://attachments.academia-assets.com/47072712/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798478/Cost_and_effectiveness_of_reduced_intensity_and_conventional_allogeneic_hematopoietic_stem_cell_transplantation_for_acute_myelogenous_leukemia_and_myelodysplastic_syndrome">Cost and effectiveness of reduced-intensity and conventional allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndrome</a></div><div class="wp-workCard_item"><span>Supportive Care in Cancer</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="77f1920bd17589e3884e6e5e662d73a5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47072712,"asset_id":26798478,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47072712/download_file?st=MTczMjg5Mjk4NSw4LjIyMi4yMDguMTQ2&st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i 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})(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "77f1920bd17589e3884e6e5e662d73a5" } } $('.js-work-strip[data-work-id=26798478]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798478,"title":"Cost and effectiveness of reduced-intensity and conventional allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndrome","translated_title":"","metadata":{"ai_title_tag":"Cost-Effectiveness of RIST vs. CST in Hematopoietic Transplant","grobid_abstract":"Goals of work Allogeneic stem cell transplantation with a reduced-intensity regimen (RIST) has been evaluated mostly in terms of its clinical benefit, and the pharmacoeconomic aspects of this procedure remain unclear. We compared the cost and effectiveness of RIST with those of stem cell transplantation using a conventional myeloablative regimen (CST). Patients and methods Fifty consecutive patients who underwent transplantation for myeloid malignancy were included. Life years and medical costs during the entire treatment course for up to 2 years after transplantation were evaluated, and cost-effectiveness was assessed from the payer's perspective. Main results Of these 50 cases, 35 were treated with CST and 15 were treated with RIST. The mean survival time was 1.5 years in CST and 1.2 years in RIST, while the mean total cost per patient within the first 2 years was $29,630 for CST and $29,466 for RIST, with no significant difference. The duration of total hospitalization was shorter in RIST than in CST; then, the cost for hospitalization represented a lower proportion of the total cost in RIST (49% of total cost) than in CST (63%). In contrast, the cost related to the conditioning regimen was significantly higher in RIST than in CST. Conclusions This result suggests that the increased cost of the conditioning regimen offsets the reduced cost of hospitalization in RIST. Although some differences were observed in the details of the cost, the total cost and mean survival were comparable between CST and RIST, and this result was confirmed by a probabilistic sensitivity analysis.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Supportive Care in 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syndrome"}],"downloadable_attachments":[{"id":47072712,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47072712/thumbnails/1.jpg","file_name":"s00520-009-0779-z20160707-31537-dianyg.pdf","download_url":"https://www.academia.edu/attachments/47072712/download_file?st=MTczMjg5Mjk4NSw4LjIyMi4yMDguMTQ2&st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cost_and_effectiveness_of_reduced_intens.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47072712/s00520-009-0779-z20160707-31537-dianyg-libre.pdf?1467876278=\u0026response-content-disposition=attachment%3B+filename%3DCost_and_effectiveness_of_reduced_intens.pdf\u0026Expires=1732896584\u0026Signature=WFwaGVTwxCfZAsBDqriYL93pA4NTCdSoiip1~6zni4goFZChfBDX3OT2lx47~TgonAEKm-VGIXyKbXLhlB40cOzoWOSn842LNW8pU6FWmJ~jf-M1rW4fX83FNfNQfVJNZ2PchF-m19HBXSioWgRxhWP2aP1avaYgQqMKS0GgPJTw-mgt1MvW8OIYMfZwoMjtpb7p0OAm~LTjqKfZVSZzsrXvT9Bkeoh1NuWklmM6xg1xDDxBhbw8tTVns-WkqJq3qbh6VGKs~iG3WNTdaFIsDWqpTU5n0w1dyzdSG63eW4nO99m7Jqo4VI4GiPkl0bo1dZFolkoEOO~b6iUP-xAvxQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cost_and_effectiveness_of_reduced_intensity_and_conventional_allogeneic_hematopoietic_stem_cell_transplantation_for_acute_myelogenous_leukemia_and_myelodysplastic_syndrome","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":50796887,"first_name":"Ryuji","middle_initials":null,"last_name":"Tanosaki","page_name":"RyujiTanosaki","domain_name":"independent","created_at":"2016-07-07T00:15:48.786-07:00","display_name":"Ryuji Tanosaki","url":"https://independent.academia.edu/RyujiTanosaki"},"attachments":[{"id":47072712,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47072712/thumbnails/1.jpg","file_name":"s00520-009-0779-z20160707-31537-dianyg.pdf","download_url":"https://www.academia.edu/attachments/47072712/download_file?st=MTczMjg5Mjk4NSw4LjIyMi4yMDguMTQ2&st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cost_and_effectiveness_of_reduced_intens.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47072712/s00520-009-0779-z20160707-31537-dianyg-libre.pdf?1467876278=\u0026response-content-disposition=attachment%3B+filename%3DCost_and_effectiveness_of_reduced_intens.pdf\u0026Expires=1732896584\u0026Signature=WFwaGVTwxCfZAsBDqriYL93pA4NTCdSoiip1~6zni4goFZChfBDX3OT2lx47~TgonAEKm-VGIXyKbXLhlB40cOzoWOSn842LNW8pU6FWmJ~jf-M1rW4fX83FNfNQfVJNZ2PchF-m19HBXSioWgRxhWP2aP1avaYgQqMKS0GgPJTw-mgt1MvW8OIYMfZwoMjtpb7p0OAm~LTjqKfZVSZzsrXvT9Bkeoh1NuWklmM6xg1xDDxBhbw8tTVns-WkqJq3qbh6VGKs~iG3WNTdaFIsDWqpTU5n0w1dyzdSG63eW4nO99m7Jqo4VI4GiPkl0bo1dZFolkoEOO~b6iUP-xAvxQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":10610,"name":"Survival 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Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":2374838,"name":"Hematopoietic Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell_Transplantation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798477"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798477/The_Role_of_PGE_2_in_the_Differentiation_of_Dendritic_Cells_How_Do_Dendritic_Cells_Influence_T_Cell_Polarization_and_Chemokine_Receptor_Expression"><img alt="Research paper thumbnail of The Role of PGE 2 in the Differentiation of Dendritic Cells: How Do Dendritic Cells Influence T-Cell Polarization and Chemokine Receptor Expression?" class="work-thumbnail" src="https://attachments.academia-assets.com/47072710/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798477/The_Role_of_PGE_2_in_the_Differentiation_of_Dendritic_Cells_How_Do_Dendritic_Cells_Influence_T_Cell_Polarization_and_Chemokine_Receptor_Expression">The Role of PGE 2 in the Differentiation of Dendritic Cells: How Do Dendritic Cells Influence T-Cell Polarization and Chemokine Receptor Expression?</a></div><div class="wp-workCard_item"><span>Stem Cells</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="15dbe918a0eabd4c00cec4eefe96f4cf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "15dbe918a0eabd4c00cec4eefe96f4cf" } } $('.js-work-strip[data-work-id=26798477]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798477,"title":"The Role of PGE 2 in the Differentiation of Dendritic Cells: How Do Dendritic Cells Influence T-Cell Polarization and Chemokine Receptor Expression?","translated_title":"","metadata":{"grobid_abstract":"The role of prostaglandin E 2 (PGE 2 ) in the function of dendritic cells (DCs), T-cell polarization, and expression of chemokine receptors was evaluated in human cells. Immature DCs were generated from peripheral blood CD14 + cells using a combination of GM-CSF and interleukin-4 (IL-4) with or without PGE 2 . On day 6, maturation of DCs was induced by the addition of tumor necrosis factor alpha with or without PGE 2 . DCs harvested on day 6 (immature DCs) or day 9 (mature DCs) were examined using functional assays. In the presence of PGE 2 , immature and mature DCs showed, phenotypically, a lower expression of CD1a and, functionally, a higher allostimulatory capacity at a high DC/T-cell ratio than control cells cultured in the absence of PGE 2 . DCs cultured in the presence of PGE 2 induced the differentiation of naïve T cells toward a helper T-cell type 1 (Th1) response, which was independent of IL-12 secretion in the basal state despite a slightly lower interferon gamma secretion compared with control cells. However, the function of cytotoxicity-stimulating autologous T cells was not augmented by the addition of PGE 2 . Immature DCs expressed the inflammatory chemokine receptors, CCR1 and CXCR4, but not CCR6, regardless of the presence or absence of PGE 2 . Mature DCs expressed CCR7 equally, measured using a migration test and the measurement of calcium flux with macrophage inflammatory protein-3β and reverse transcription-polymerase chain reaction assay in all of the groups. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20734052"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20734052/Freeze_Thawing_Procedures_Have_No_Influence_on_the_Phenotypic_and_Functional_Development_of_Dendritic_Cells_Generated_from_Peripheral_Blood_CD14_Monocytes"><img alt="Research paper thumbnail of Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20734052/Freeze_Thawing_Procedures_Have_No_Influence_on_the_Phenotypic_and_Functional_Development_of_Dendritic_Cells_Generated_from_Peripheral_Blood_CD14_Monocytes">Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/TadaoKakizoe">Tadao Kakizoe</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RyujiTanosaki">Ryuji Tanosaki</a></span></div><div class="wp-workCard_item"><span>Journal of Immunotherapy</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Little is known about the potential influence of cryopreservation on the biologic activities of d...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Little is known about the potential influence of cryopreservation on the biologic activities of dendritic cells (DCs). In this study, we examined the effects of freeze-thawing on the phenotypic and functional development of human DCs obtained from granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood CD14+ cells. CD14+ cells were cultured, immediately or after freeze-thawing, with granulocyte-macrophage CSF and interleukin-4 for 9 days, and then with added tumor necrosis factor-alpha for another 3 days. For both fresh and freeze-thawed monocytes, immature DCs harvested on day 6 and mature DCs harvested on day 9 of culture were examined under the same conditions. Cells were compared with regard to their 1) capacities for antigen endocytosis and chemotactic migration (immature DCs), and 2) allogeneic mixed lymphocyte reaction and antigen-specific cytotoxic T lymphocyte responses (mature DCs). Freeze-thawing did not affect the viability or subsequent maturation of DCs at any stage of development. Furthermore, essentially no difference was observed in phenotype or function between cells generated from fresh or cryopreserved/thawed cells. Although this study design was limited with the use of fetal bovine serum, the observation still suggests that freeze-thawing does not affect viability, phenotype, subsequent maturation, or functions of DCs at any stage of maturation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20734052"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20734052"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20734052; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20734052]").text(description); $(".js-view-count[data-work-id=20734052]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20734052; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20734052']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20734052, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20734052]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20734052,"title":"Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes","translated_title":"","metadata":{"abstract":"Little is known about the potential influence of cryopreservation on the biologic activities of dendritic cells (DCs). In this study, we examined the effects of freeze-thawing on the phenotypic and functional development of human DCs obtained from granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood CD14+ cells. CD14+ cells were cultured, immediately or after freeze-thawing, with granulocyte-macrophage CSF and interleukin-4 for 9 days, and then with added tumor necrosis factor-alpha for another 3 days. For both fresh and freeze-thawed monocytes, immature DCs harvested on day 6 and mature DCs harvested on day 9 of culture were examined under the same conditions. Cells were compared with regard to their 1) capacities for antigen endocytosis and chemotactic migration (immature DCs), and 2) allogeneic mixed lymphocyte reaction and antigen-specific cytotoxic T lymphocyte responses (mature DCs). Freeze-thawing did not affect the viability or subsequent maturation of DCs at any stage of development. Furthermore, essentially no difference was observed in phenotype or function between cells generated from fresh or cryopreserved/thawed cells. Although this study design was limited with the use of fetal bovine serum, the observation still suggests that freeze-thawing does not affect viability, phenotype, subsequent maturation, or functions of DCs at any stage of maturation.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Journal of Immunotherapy"},"translated_abstract":"Little is known about the potential influence of cryopreservation on the biologic activities of dendritic cells (DCs). In this study, we examined the effects of freeze-thawing on the phenotypic and functional development of human DCs obtained from granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood CD14+ cells. CD14+ cells were cultured, immediately or after freeze-thawing, with granulocyte-macrophage CSF and interleukin-4 for 9 days, and then with added tumor necrosis factor-alpha for another 3 days. For both fresh and freeze-thawed monocytes, immature DCs harvested on day 6 and mature DCs harvested on day 9 of culture were examined under the same conditions. Cells were compared with regard to their 1) capacities for antigen endocytosis and chemotactic migration (immature DCs), and 2) allogeneic mixed lymphocyte reaction and antigen-specific cytotoxic T lymphocyte responses (mature DCs). Freeze-thawing did not affect the viability or subsequent maturation of DCs at any stage of development. Furthermore, essentially no difference was observed in phenotype or function between cells generated from fresh or cryopreserved/thawed cells. Although this study design was limited with the use of fetal bovine serum, the observation still suggests that freeze-thawing does not affect viability, phenotype, subsequent maturation, or functions of DCs at any stage of maturation.","internal_url":"https://www.academia.edu/20734052/Freeze_Thawing_Procedures_Have_No_Influence_on_the_Phenotypic_and_Functional_Development_of_Dendritic_Cells_Generated_from_Peripheral_Blood_CD14_Monocytes","translated_internal_url":"","created_at":"2016-01-24T19:15:27.951-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42031465,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":13624063,"work_id":20734052,"tagging_user_id":42031465,"tagged_user_id":null,"co_author_invite_id":1890015,"email":"s***u@nips.ac.jp","display_order":0,"name":"Shigeru Saito","title":"Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes"},{"id":13624212,"work_id":20734052,"tagging_user_id":42031465,"tagged_user_id":null,"co_author_invite_id":3187129,"email":"h***i@red.umds.ac.jp","display_order":4194304,"name":"Hiroyuki Kawai","title":"Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes"},{"id":13624227,"work_id":20734052,"tagging_user_id":42031465,"tagged_user_id":50796887,"co_author_invite_id":3187135,"email":"r***k@ncc.go.jp","display_order":6291456,"name":"Ryuji Tanosaki","title":"Freeze-Thawing Procedures Have No Influence on the Phenotypic and Functional Development of Dendritic Cells Generated from Peripheral Blood CD14+ Monocytes"}],"downloadable_attachments":[],"slug":"Freeze_Thawing_Procedures_Have_No_Influence_on_the_Phenotypic_and_Functional_Development_of_Dendritic_Cells_Generated_from_Peripheral_Blood_CD14_Monocytes","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42031465,"first_name":"Tadao","middle_initials":null,"last_name":"Kakizoe","page_name":"TadaoKakizoe","domain_name":"independent","created_at":"2016-01-24T19:14:37.893-08:00","display_name":"Tadao Kakizoe","url":"https://independent.academia.edu/TadaoKakizoe"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":19295,"name":"Cryopreservation","url":"https://www.academia.edu/Documents/in/Cryopreservation"},{"id":35539,"name":"Dendritic Cells","url":"https://www.academia.edu/Documents/in/Dendritic_Cells"},{"id":126863,"name":"Immunotherapy","url":"https://www.academia.edu/Documents/in/Immunotherapy"},{"id":153279,"name":"Dendritic cell","url":"https://www.academia.edu/Documents/in/Dendritic_cell"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":402972,"name":"Monocytes","url":"https://www.academia.edu/Documents/in/Monocytes"},{"id":957359,"name":"Culture Media","url":"https://www.academia.edu/Documents/in/Culture_Media"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798476"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798476/Ex_vivo_manipulation_of_umbilical_cord_blood_derived_hematopoietic_stem_progenitor_cells_with_recombinant_human_stem_cell_factor_can_up_regulate_levels_of_homing_essential_molecules_to_increase_their_transmigratory_potential"><img alt="Research paper thumbnail of Ex vivo manipulation of umbilical cord blood-derived hematopoietic stem/progenitor cells with recombinant human stem cell factor can up-regulate levels of homing-essential molecules to increase their transmigratory potential" class="work-thumbnail" src="https://attachments.academia-assets.com/47072709/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798476/Ex_vivo_manipulation_of_umbilical_cord_blood_derived_hematopoietic_stem_progenitor_cells_with_recombinant_human_stem_cell_factor_can_up_regulate_levels_of_homing_essential_molecules_to_increase_their_transmigratory_potential">Ex vivo manipulation of umbilical cord blood-derived hematopoietic stem/progenitor cells with recombinant human stem cell factor can up-regulate levels of homing-essential molecules to increase their transmigratory potential</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RyujiTanosaki">Ryuji Tanosaki</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ArinobuTojo">Arinobu Tojo</a></span></div><div class="wp-workCard_item"><span>Experimental Hematology</span><span>, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="89778cdbe08a52e710d58dd37f622a7c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47072709,"asset_id":26798476,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47072709/download_file?st=MTczMjg5Mjk4NSw4LjIyMi4yMDguMTQ2&st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798476"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798476"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798476; 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The cause of delayed hematopoietic reconstitution after umbilical cord blood transplantation (UCBT) remains controversial. We hypothesized that hematopoietic stem/ progenitor cells (HS/PCs) from UCB have some defects of the homing-related molecules responsible for their slow engraftment. Materials and Methods. A homing-related molecule repertoire expressed on HS/PCs from fresh and cryopreserved UCB, mobilized peripheral blood (mPB), and bone marrow (BM) were compared using sensitive, four-color fluorescence-activated cell sorting analysis. Purified CD34 ϩ cells were subjected to ex vivo transmigration through double-coated transwell filter inserts, and an in vivo homing assay was performed in xenotransplanted NOD/SCID mice. Results. UCB-derived CD34 bright cells expressed significantly lower levels of CD49e, CD49f, and CXCR-4 than their mPB and BM counterparts. CD34 ϩ cells from UCB (and BM) exhibited significantly lower ex vivo transmigration than those from mPB, which were largely blocked by neutralizing antibodies to CD49e or CD49f. Recombinant human tumor necrosis factor-a treatment enhanced ex vivo transmigration of CD34 ϩ cells from UCB and BM by inducing expression of the matrix metalloproteinases MMP-2/MMP-9. Short-term treatment of UCBderived CD34 ϩ cells with rHu-stem cell factor (rHuSCF) up-regulated levels of the homingrelated molecules with their increased ex vivo transmigratory and in vivo homing potential.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Experimental Hematology","grobid_abstract_attachment_id":47072709},"translated_abstract":null,"internal_url":"https://www.academia.edu/26798476/Ex_vivo_manipulation_of_umbilical_cord_blood_derived_hematopoietic_stem_progenitor_cells_with_recombinant_human_stem_cell_factor_can_up_regulate_levels_of_homing_essential_molecules_to_increase_their_transmigratory_potential","translated_internal_url":"","created_at":"2016-07-07T00:18:32.259-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50796887,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22150167,"work_id":26798476,"tagging_user_id":50796887,"tagged_user_id":50804220,"co_author_invite_id":4944598,"email":"a***o@ims.u-tokyo.ac.jp","display_order":0,"name":"Arinobu Tojo","title":"Ex vivo manipulation of umbilical cord blood-derived hematopoietic stem/progenitor cells with recombinant human stem cell factor can up-regulate levels of homing-essential molecules to increase their transmigratory potential"}],"downloadable_attachments":[{"id":47072709,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47072709/thumbnails/1.jpg","file_name":"Ex_vivo_manipulation_of_umbilical_cord_b20160707-31546-1r7ka3f.pdf","download_url":"https://www.academia.edu/attachments/47072709/download_file?st=MTczMjg5Mjk4NSw4LjIyMi4yMDguMTQ2&st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Ex_vivo_manipulation_of_umbilical_cord_b.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47072709/Ex_vivo_manipulation_of_umbilical_cord_b20160707-31546-1r7ka3f-libre.pdf?1467876279=\u0026response-content-disposition=attachment%3B+filename%3DEx_vivo_manipulation_of_umbilical_cord_b.pdf\u0026Expires=1732896584\u0026Signature=UQEP~Jeslqtf5N4BaX5uD58UgT7v8ZziJKPi5jRzT~IJotQfFUIkHN8R~hSfXSJbWdW~RY~yWEDShy1o7s41ya45WyD3Td9sviNT~9FmnSsxhtE9AjLD-FASj-AIpjfHgdCXUlYK3G0jOjZOy95lEW7~qhW~8nkG6R~6~FU04h-MO7hgGO-CLjXEv2mVee2-a65gauMA5dK5IY9rnwysIlZ7NdSYm0ie~wdalTqplGmBKoXsEuhOa~SES2ssKNAhNi3j8~eyYvnm8N24L8tKAIR7Xa0U24PI8LyKEUQtwsFmGrTmLMuV1Dq7UoeR1ipUxEAlc2794ElLrAAcNuZZcg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Ex_vivo_manipulation_of_umbilical_cord_blood_derived_hematopoietic_stem_progenitor_cells_with_recombinant_human_stem_cell_factor_can_up_regulate_levels_of_homing_essential_molecules_to_increase_their_transmigratory_potential","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":50796887,"first_name":"Ryuji","middle_initials":null,"last_name":"Tanosaki","page_name":"RyujiTanosaki","domain_name":"independent","created_at":"2016-07-07T00:15:48.786-07:00","display_name":"Ryuji 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and chemokine receptors","url":"https://www.academia.edu/Documents/in/Chemokines_and_chemokine_receptors"},{"id":53113,"name":"Hematopoietic Stem Cells","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cells"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":170276,"name":"Chemotaxis","url":"https://www.academia.edu/Documents/in/Chemotaxis"},{"id":224883,"name":"Integrins","url":"https://www.academia.edu/Documents/in/Integrins"},{"id":232443,"name":"Umbilical Cord Blood","url":"https://www.academia.edu/Documents/in/Umbilical_Cord_Blood"},{"id":990417,"name":"Recombinant Proteins","url":"https://www.academia.edu/Documents/in/Recombinant_Proteins"},{"id":1824499,"name":"Cell Adhesion Molecules","url":"https://www.academia.edu/Documents/in/Cell_Adhesion_Molecules"},{"id":2374838,"name":"Hematopoietic Stem Cell Transplantation","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cell_Transplantation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26798475"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26798475/Treatment_of_advanced_myelodysplastic_syndrome_with_a_regimen_including_recombinant_human_granulocyte_colony_stimulating_factor_preceding_allogeneic_bone_marrow_transplantation"><img alt="Research paper thumbnail of Treatment of advanced myelodysplastic syndrome with a regimen including recombinant human granulocyte colony-stimulating factor preceding allogeneic bone marrow transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/47072711/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798475/Treatment_of_advanced_myelodysplastic_syndrome_with_a_regimen_including_recombinant_human_granulocyte_colony_stimulating_factor_preceding_allogeneic_bone_marrow_transplantation">Treatment of advanced myelodysplastic syndrome with a regimen including recombinant human granulocyte colony-stimulating factor preceding allogeneic bone marrow transplantation</a></div><div class="wp-workCard_item"><span>British Journal of Haematology</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9c5bbfcb80ca4088ca19628f45e667a4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47072711,"asset_id":26798475,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47072711/download_file?st=MTczMjg5Mjk4NSw4LjIyMi4yMDguMTQ2&st=MTczMjg5Mjk4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26798475"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26798475"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26798475; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26798475]").text(description); $(".js-view-count[data-work-id=26798475]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26798475; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26798475']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26798475, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9c5bbfcb80ca4088ca19628f45e667a4" } } $('.js-work-strip[data-work-id=26798475]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26798475,"title":"Treatment of advanced myelodysplastic syndrome with a regimen including recombinant human granulocyte colony-stimulating factor preceding allogeneic bone marrow transplantation","translated_title":"","metadata":{"grobid_abstract":"We treated 13 patients with morphologically advanced myelodysplastic syndrome using cytosine arabinoside and total body irradiation, followed by allogeneic marrow transplantation from HLA-identical sibling donors. Granulocyte colony-stimulating factor (G-CSF) was added to the preparative regimen to selectively increase chemosensitivity of leukaemic cells and to improve transplant outcome. No regimen-related deaths occurred, and no side-effects related to the addition of G-CSF were observed except for transient mild bone pain. At a median follow-up time of 39 months the projected 5-year disease-free survival and 5-year overall survival were 67·7% and 75·5%, respectively, with only one case showing cytogenetic relapse. The preparative regimen including G-CSF is feasible, and preliminary results seem to be encouraging. 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Adults with acute leukaemia who relapsed after allo-SCT had a median survival of 3-4 months if no treatment was given . Approaches to treating patients in relapse after allo-SCT include rapid tapering of immunosuppressive agents, donor lymphocyte infusion (DLI), re-induction chemotherapy and second transplantation. Standard chemotherapy sometimes results in complete remission (CR), but long-term disease-free survival (DFS) is unlikely, because of regimen-related toxicity (RRT) and recurrence . Although a second allograft produces sustained molecular remission in a proportion of patients, transplant-related mortality (TRM) is high with 100-d mortality rates of 25-50% and a DFS of 10% . Poor prognostic factors after second allo-SCT include an interval between the procedures of \u003c1 year, resistance to re-induction chemotherapy, older age and poor performance status . 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href="https://www.academia.edu/26798473/Decreased_insulin_secretion_in_patients_receiving_tacrolimus_as_GVHD_prophylaxis_after_allogeneic_hematopoietic_SCT"><img alt="Research paper thumbnail of Decreased insulin secretion in patients receiving tacrolimus as GVHD prophylaxis after allogeneic hematopoietic SCT" class="work-thumbnail" src="https://attachments.academia-assets.com/47072705/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798473/Decreased_insulin_secretion_in_patients_receiving_tacrolimus_as_GVHD_prophylaxis_after_allogeneic_hematopoietic_SCT">Decreased insulin secretion in patients receiving tacrolimus as GVHD prophylaxis after allogeneic hematopoietic SCT</a></div><div class="wp-workCard_item"><span>Bone Marrow Transplantation</span><span>, 2010</span></div><div 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{"id":26798473,"title":"Decreased insulin secretion in patients receiving tacrolimus as GVHD prophylaxis after allogeneic hematopoietic SCT","translated_title":"","metadata":{"grobid_abstract":"Fasting glucose level (mg per 100 ml) Pretransplant 87 (80-129) ] P ¼ 0.08 89 (79-154) ] P ¼ 0.55 Posttransplant 95 (79-129) 91 (80-116) Immunoreactive insulin level (mU/ml) Pretransplant 6.1 (1.6-17.3) ] P ¼ 0.60 6.6 (2.9-13.5) ] P ¼ 0.25 Posttransplant 6.5 (1.5-18.0) 5.3 (2.4-10.1) HOMA-IR Pretransplant 1.4 (0.3-4.6) ] P ¼ 0.75 1.4 (0.6-5.13) ] P ¼ 0.40 Posttransplant 1.5 (0.3-4.2) 1.3 (0.5-2.2) HOMA-b Pretransplant 90.9 (30.3-193.7) ] P ¼ 0.04 65.4 (38.7-160.0) ] P ¼ 0.43 Posttransplant 69.9 (15.8-202.5) 61.7 (28.5-180.0) Abbreviations: HOMA ¼ homeostasis model assessment; IR ¼ insulin resistance.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Bone Marrow 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transplantation for adult T-cell leukemia: a retrospective cohort study" class="work-thumbnail" src="https://attachments.academia-assets.com/47072706/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26798472/Impact_of_graft_versus_host_disease_on_outcomes_after_allogeneic_hematopoietic_cell_transplantation_for_adult_T_cell_leukemia_a_retrospective_cohort_study">Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study</a></div><div class="wp-workCard_item"><span>Blood</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8b6fd653f40e0e54b7f81c53a0149b7c" class="wp-workCard--action" 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study","translated_title":"","metadata":{"grobid_abstract":", raising the question about the role of graft-versusleukemia effect against ATL. In this study, we retrospectively analyzed the effects of acute and chronic graft-versus-host disease (GVHD) on overall survival, diseaseassociated mortality, and treatmentrelated mortality among 294 ATL patients who received allogeneic HCT and survived at least 30 days posttransplant with sustained engraftment. Multivariate anal-yses treating the occurrence of GVHD as a time-varying covariate demonstrated that the development of grade 1-2 acute GVHD was significantly associated with higher overall survival (hazard ratio [HR] for death, 0.65; P ‫؍‬ .018) compared with the absence of acute GVHD. Occurrence of either grade 1-2 or grade 3-4 acute GVHD was associated with lower diseaseassociated mortality compared with the absence of acute GVHD, whereas grade 3-4 acute GVHD was associated with a higher risk for treatment-related mortality (HR, 3.50; P \u003c .001). The development of extensive chronic GVHD was associated with higher treatment-related mortality (HR, 2.75; P ‫؍‬ .006) compared with the absence of chronic GVHD. Collectively, these results indicate that the development of mild-to-moderate acute GVHD confers a lower risk of disease progression and a beneficial influence on survival of allografted patients with ATL.","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Blood","grobid_abstract_attachment_id":47072706},"translated_abstract":null,"internal_url":"https://www.academia.edu/26798472/Impact_of_graft_versus_host_disease_on_outcomes_after_allogeneic_hematopoietic_cell_transplantation_for_adult_T_cell_leukemia_a_retrospective_cohort_study","translated_internal_url":"","created_at":"2016-07-07T00:18:31.495-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50796887,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22150173,"work_id":26798472,"tagging_user_id":50796887,"tagged_user_id":null,"co_author_invite_id":4944604,"email":"s***i@cayenne-p.co.jp","display_order":0,"name":"S. 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