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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Graft Rejection</h1><div class="u-tcGrayDark">21 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Graft Rejection</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Graft_Rejection">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Graft_Rejection/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Graft_Rejection/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Graft_Rejection/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Graft_Rejection">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15668749" data-work_id="15668749" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15668749/_Immuknow_to_Measurement_of_Cell_Mediated_Immunity_in_Renal_Transplant_Recipients_Undergoing_Short_Term_Evaluation">“Immuknow” to Measurement of Cell-Mediated Immunity in Renal Transplant Recipients Undergoing Short-Term Evaluation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of this preliminary, observational study was to evaluate the value of ImmuKnow (IK), a new tool to measure the net state of immunefunction among renal transplant recipients, in correlation with clinical and laboratory data among... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_15668749" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of this preliminary, observational study was to evaluate the value of ImmuKnow (IK), a new tool to measure the net state of immunefunction among renal transplant recipients, in correlation with clinical and laboratory data among unselected renal transplant recipients. Forty-nine recipients of mean age of 51 years were enrolled and followed for 1 year after transplantation. All subjects received the same immunosuppressive strategy with basiliximab induction and tacrolimus, mycophenolate mofetil and steroid maintenance therapy. Samples for IK were collected before transplantation as well as at 7, 14, 21 and 42 days and after 3, 6, and 12 months. There were 54 samples with IK Ͻ225 ng/mL, 201 samples with normal IK values, and 135 samples with Ͼ525 ng/mL. We divided recipients into 3 groups with respect to their basal IK values: Group 1 (Gr1; IK Ͻ225 ng/mL); Group 2 (Gr2; normal values of IK between 226 and 524 ng/mL); and Group 3 (Gr3; IK Ͼ525 ng/mL). At 1 year, we observed a significant difference among IK values at the start and the end of the study: Gr1 vs Gr2, P Ͻ .0001; Gr2 vs Gr3, P Ͻ .06 and Gr 1 vs Gr 3, P Ͻ .01). We observed reduced IK values to predict an increased risk of infection, particularly with cytomegalovirus (CMV) replication while higher IK value did not correlate with an increased risk of acute rejection episodes. Reduction of serum creatine levels occurred within 1 year in all groups (P Ͻ .005), but there was a significant difference between Gr 2 versus Grs 1 and 3 (P Ͻ .0001 and P Ͻ .0005, respectively). There findings suggested that more stable IK values were associated with clinical quiescence and laboratory stability. In conclusion, our preliminary analysis showed a beneficial capacity of this assay to represent the global depression of the immune system. We noted that reduced IK values, as a sign of excessive immunosuppressive therapy, were associated with an increased risk of infection. We did not confirm the predictive value of higher IK values for an increased risk of an acute rejection episode.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15668749" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="cfeeecf6044fdc2974b12237900458e8" rel="nofollow" data-download="{"attachment_id":42987039,"asset_id":15668749,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42987039/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34855933" href="https://independent.academia.edu/ChiaraAgrati">Chiara Agrati</a><script data-card-contents-for-user="34855933" type="text/json">{"id":34855933,"first_name":"Chiara","last_name":"Agrati","domain_name":"independent","page_name":"ChiaraAgrati","display_name":"Chiara Agrati","profile_url":"https://independent.academia.edu/ChiaraAgrati?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_15668749 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="15668749"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 15668749, container: ".js-paper-rank-work_15668749", }); 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$(".js-view-count[data-work-id=15668749]").text(description); $(".js-view-count-work_15668749").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_15668749").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="15668749"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">26</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9003" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_transplantation">Kidney transplantation</a>, <script data-card-contents-for-ri="9003" type="text/json">{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="16664" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk_assessment">Risk assessment</a>, <script data-card-contents-for-ri="16664" type="text/json">{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="24856" rel="nofollow" href="https://www.academia.edu/Documents/in/STEROIDS">STEROIDS</a><script data-card-contents-for-ri="24856" type="text/json">{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=15668749]'), work: {"id":15668749,"title":"“Immuknow” to Measurement of Cell-Mediated Immunity in Renal Transplant Recipients Undergoing Short-Term Evaluation","created_at":"2015-09-13T22:50:05.640-07:00","url":"https://www.academia.edu/15668749/_Immuknow_to_Measurement_of_Cell_Mediated_Immunity_in_Renal_Transplant_Recipients_Undergoing_Short_Term_Evaluation?f_ri=893785","dom_id":"work_15668749","summary":"The aim of this preliminary, observational study was to evaluate the value of ImmuKnow (IK), a new tool to measure the net state of immunefunction among renal transplant recipients, in correlation with clinical and laboratory data among unselected renal transplant recipients. Forty-nine recipients of mean age of 51 years were enrolled and followed for 1 year after transplantation. All subjects received the same immunosuppressive strategy with basiliximab induction and tacrolimus, mycophenolate mofetil and steroid maintenance therapy. Samples for IK were collected before transplantation as well as at 7, 14, 21 and 42 days and after 3, 6, and 12 months. There were 54 samples with IK Ͻ225 ng/mL, 201 samples with normal IK values, and 135 samples with Ͼ525 ng/mL. We divided recipients into 3 groups with respect to their basal IK values: Group 1 (Gr1; IK Ͻ225 ng/mL); Group 2 (Gr2; normal values of IK between 226 and 524 ng/mL); and Group 3 (Gr3; IK Ͼ525 ng/mL). At 1 year, we observed a significant difference among IK values at the start and the end of the study: Gr1 vs Gr2, P Ͻ .0001; Gr2 vs Gr3, P Ͻ .06 and Gr 1 vs Gr 3, P Ͻ .01). We observed reduced IK values to predict an increased risk of infection, particularly with cytomegalovirus (CMV) replication while higher IK value did not correlate with an increased risk of acute rejection episodes. Reduction of serum creatine levels occurred within 1 year in all groups (P Ͻ .005), but there was a significant difference between Gr 2 versus Grs 1 and 3 (P Ͻ .0001 and P Ͻ .0005, respectively). There findings suggested that more stable IK values were associated with clinical quiescence and laboratory stability. In conclusion, our preliminary analysis showed a beneficial capacity of this assay to represent the global depression of the immune system. We noted that reduced IK values, as a sign of excessive immunosuppressive therapy, were associated with an increased risk of infection. We did not confirm the predictive value of higher IK values for an increased risk of an acute rejection episode.","downloadable_attachments":[{"id":42987039,"asset_id":15668749,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34855933,"first_name":"Chiara","last_name":"Agrati","domain_name":"independent","page_name":"ChiaraAgrati","display_name":"Chiara Agrati","profile_url":"https://independent.academia.edu/ChiaraAgrati?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=893785","nofollow":true},{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS?f_ri=893785","nofollow":true},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=893785"},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus?f_ri=893785"},{"id":58380,"name":"Therapeutic drug monitoring","url":"https://www.academia.edu/Documents/in/Therapeutic_drug_monitoring?f_ri=893785"},{"id":112993,"name":"Cytomegalovirus","url":"https://www.academia.edu/Documents/in/Cytomegalovirus?f_ri=893785"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies?f_ri=893785"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=893785"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=893785"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system?f_ri=893785"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=893785"},{"id":487159,"name":"Group","url":"https://www.academia.edu/Documents/in/Group?f_ri=893785"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=893785"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy?f_ri=893785"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=893785"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":910024,"name":"Observational Study","url":"https://www.academia.edu/Documents/in/Observational_Study?f_ri=893785"},{"id":945595,"name":"Pilot Projects","url":"https://www.academia.edu/Documents/in/Pilot_Projects?f_ri=893785"},{"id":1007684,"name":"Virus diseases","url":"https://www.academia.edu/Documents/in/Virus_diseases?f_ri=893785"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=893785"},{"id":1740530,"name":"Mycophenolate mofetil","url":"https://www.academia.edu/Documents/in/Mycophenolate_mofetil?f_ri=893785"},{"id":1740532,"name":"Acute rejection","url":"https://www.academia.edu/Documents/in/Acute_rejection?f_ri=893785"},{"id":1816594,"name":"Adenosine Triphosphate","url":"https://www.academia.edu/Documents/in/Adenosine_Triphosphate?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21911336" data-work_id="21911336" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21911336/Validation_of_the_Maryland_Aggregate_Pathology_Index_MAPI_a_pre_implantation_scoring_system_that_predicts_graft_outcome">Validation of the Maryland Aggregate Pathology Index (MAPI), a pre-implantation scoring system that predicts graft outcome</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">RB. Validation of the Maryland Aggregate Pathology Index (MAPI), a preimplantation scoring system that predicts graft outcome.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21911336" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7653b04560310971b842dfe11ea63d9c" rel="nofollow" data-download="{"attachment_id":42644421,"asset_id":21911336,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42644421/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43152594" href="https://drexel.academia.edu/KarthikRanganna">Karthik Ranganna</a><script data-card-contents-for-user="43152594" type="text/json">{"id":43152594,"first_name":"Karthik","last_name":"Ranganna","domain_name":"drexel","page_name":"KarthikRanganna","display_name":"Karthik Ranganna","profile_url":"https://drexel.academia.edu/KarthikRanganna?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21911336 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21911336"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21911336, container: ".js-paper-rank-work_21911336", }); 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$(".js-view-count[data-work-id=21911336]").text(description); $(".js-view-count-work_21911336").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21911336").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21911336"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9003" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_transplantation">Kidney transplantation</a>, <script data-card-contents-for-ri="9003" type="text/json">{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" rel="nofollow" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a>, <script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="192721" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk_factors">Risk factors</a>, <script data-card-contents-for-ri="192721" type="text/json">{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="210652" rel="nofollow" href="https://www.academia.edu/Documents/in/Maryland">Maryland</a><script data-card-contents-for-ri="210652" type="text/json">{"id":210652,"name":"Maryland","url":"https://www.academia.edu/Documents/in/Maryland?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21911336]'), work: {"id":21911336,"title":"Validation of the Maryland Aggregate Pathology Index (MAPI), a pre-implantation scoring system that predicts graft outcome","created_at":"2016-02-13T05:07:36.957-08:00","url":"https://www.academia.edu/21911336/Validation_of_the_Maryland_Aggregate_Pathology_Index_MAPI_a_pre_implantation_scoring_system_that_predicts_graft_outcome?f_ri=893785","dom_id":"work_21911336","summary":"RB. Validation of the Maryland Aggregate Pathology Index (MAPI), a preimplantation scoring system that predicts graft outcome.","downloadable_attachments":[{"id":42644421,"asset_id":21911336,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43152594,"first_name":"Karthik","last_name":"Ranganna","domain_name":"drexel","page_name":"KarthikRanganna","display_name":"Karthik Ranganna","profile_url":"https://drexel.academia.edu/KarthikRanganna?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=893785","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=893785","nofollow":true},{"id":210652,"name":"Maryland","url":"https://www.academia.edu/Documents/in/Maryland?f_ri=893785","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785"},{"id":277616,"name":"Preimplantation genetic diagnosis","url":"https://www.academia.edu/Documents/in/Preimplantation_genetic_diagnosis?f_ri=893785"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=893785"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21649685" data-work_id="21649685" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21649685/Immunological_rejection_of_heart_transplant_how_lytic_granules_from_cytotoxic_T_lymphocytes_damage_guinea_pig_ventricular_myocytes">Immunological rejection of heart transplant: how lytic granules from cytotoxic T lymphocytes damage guinea pig ventricular myocytes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We investigated the mechanism by which lytic granules extracted from cytotoxic T lymphocytes (CTL) damage guinea pig ventricular myocytes in order to dertermine whether their actions can be related to the overall immunological rejection... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21649685" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We investigated the mechanism by which lytic granules extracted from cytotoxic T lymphocytes (CTL) damage guinea pig ventricular myocytes in order to dertermine whether their actions can be related to the overall immunological rejection of the transplanted heart. Granule-induced myocyte morphological changes and final destruction were preceded by shortening of action potential duration (APD) and reductions of the resting potential and the action potential amplitude. APD shortening was probably caused by a granule-induced increase in outward current (most likely non-specific). Ryanodine, which blocks Ca 2+ release from the sacroplasmic reticulum, did not interfere with the morphological and electrophysiological effects of lytic granules. Fura-2 imaging indicated that [caa+] i initially increased about 2-fold from 90.0_ll.5nM, while cell length decreased less than 5% from a mean value of 99.0+_9.0 I-tm. A further increase in [Ca2+] i (> 10 fold) was associated with progressive contracture and destruction, suggesting that the structural damage inflicted by lytic granules is caused by [Ca2+] i overload. The results indicate that the cytocidal action of CTL-derived lyric granules may be involved in immunologically induced damage, even to the extent of rejection of the transplanted heart.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21649685" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b24060eeaca4c3ca1803d95b00653b89" rel="nofollow" data-download="{"attachment_id":42283475,"asset_id":21649685,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42283475/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42796521" href="https://weizmann.academia.edu/GideonBerke">Gideon Berke</a><script data-card-contents-for-user="42796521" type="text/json">{"id":42796521,"first_name":"Gideon","last_name":"Berke","domain_name":"weizmann","page_name":"GideonBerke","display_name":"Gideon Berke","profile_url":"https://weizmann.academia.edu/GideonBerke?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21649685 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21649685"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21649685, container: ".js-paper-rank-work_21649685", }); 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Granule-induced myocyte morphological changes and final destruction were preceded by shortening of action potential duration (APD) and reductions of the resting potential and the action potential amplitude. APD shortening was probably caused by a granule-induced increase in outward current (most likely non-specific). Ryanodine, which blocks Ca 2+ release from the sacroplasmic reticulum, did not interfere with the morphological and electrophysiological effects of lytic granules. Fura-2 imaging indicated that [caa+] i initially increased about 2-fold from 90.0_ll.5nM, while cell length decreased less than 5% from a mean value of 99.0+_9.0 I-tm. A further increase in [Ca2+] i (\u003e 10 fold) was associated with progressive contracture and destruction, suggesting that the structural damage inflicted by lytic granules is caused by [Ca2+] i overload. The results indicate that the cytocidal action of CTL-derived lyric granules may be involved in immunologically induced damage, even to the extent of rejection of the transplanted heart.","downloadable_attachments":[{"id":42283475,"asset_id":21649685,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42796521,"first_name":"Gideon","last_name":"Berke","domain_name":"weizmann","page_name":"GideonBerke","display_name":"Gideon Berke","profile_url":"https://weizmann.academia.edu/GideonBerke?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=893785","nofollow":true},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=893785","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=893785","nofollow":true},{"id":392828,"name":"Myocardium","url":"https://www.academia.edu/Documents/in/Myocardium?f_ri=893785","nofollow":true},{"id":485556,"name":"Guinea Pig","url":"https://www.academia.edu/Documents/in/Guinea_Pig?f_ri=893785"},{"id":666669,"name":"Action potential","url":"https://www.academia.edu/Documents/in/Action_potential?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":955727,"name":"Action Potentials","url":"https://www.academia.edu/Documents/in/Action_Potentials?f_ri=893785"},{"id":987931,"name":"Heart Transplantation","url":"https://www.academia.edu/Documents/in/Heart_Transplantation?f_ri=893785"},{"id":1154249,"name":"Heart Ventricles","url":"https://www.academia.edu/Documents/in/Heart_Ventricles?f_ri=893785"},{"id":1320031,"name":"Action Potential Duration","url":"https://www.academia.edu/Documents/in/Action_Potential_Duration?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_63775163" data-work_id="63775163" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/63775163/Clinical_utility_of_monitoring_tacrolimus_blood_concentrations_in_liver_transplant_patients">Clinical utility of monitoring tacrolimus blood concentrations in liver transplant patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">T he contribution of tacrolimus to effective immunosuppression in the field of organ transplantation is well established. 1-4 While tacrolimus is a potent immunosuppressive drug, it has a narrow therapeutic index. 5-7 The large... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_63775163" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">T he contribution of tacrolimus to effective immunosuppression in the field of organ transplantation is well established. 1-4 While tacrolimus is a potent immunosuppressive drug, it has a narrow therapeutic index. 5-7 The large interindividual variation in the pharmacokinetics of tacrolimus necessitates individualization of the dosing regimen of tacrolimus in transplant patients. 8-10 In addition, to achieve long-term graft survival, it is essential that the patients are compliant with the prescribed dosing regimen. Optimization of tacrolimus therapy in organ transplant patients currently uses routine tacrolimus trough-level monitoring as an integral component. 11-12 One of the fundamental premises in the application of therapeutic drug 542</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/63775163" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b0fdb13149a1956ebd6faffed9ede8f8" rel="nofollow" data-download="{"attachment_id":76087347,"asset_id":63775163,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76087347/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35152331" href="https://independent.academia.edu/KBrayman">K. 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Optimization of tacrolimus therapy in organ transplant patients currently uses routine tacrolimus trough-level monitoring as an integral component. 11-12 One of the fundamental premises in the application of therapeutic drug 542","downloadable_attachments":[{"id":76087347,"asset_id":63775163,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35152331,"first_name":"K.","last_name":"Brayman","domain_name":"independent","page_name":"KBrayman","display_name":"K. 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Major outcomes included the elimination of the non-specific term 'chronic allograft nephropathy' (CAN) from the Banff classification for kidney... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_2175783" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The 8th Banff Conference on Allograft Pathology was held in Edmonton, Canada, 15-21 July 2005. Major outcomes included the elimination of the non-specific term 'chronic allograft nephropathy' (CAN) from the Banff classification for kidney allograft pathology, and the recognition of the entity of chronic antibody-mediated rejection. Participation of B cells in allograft rejection and genomics markers of rejection were also major subjects addressed by the conference.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/2175783" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="34790c094d3ad39da8442a52804c741e" rel="nofollow" data-download="{"attachment_id":30228847,"asset_id":2175783,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/30228847/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="2795255" href="https://ualberta.academia.edu/KimSolez">Kim Solez</a><script data-card-contents-for-user="2795255" type="text/json">{"id":2795255,"first_name":"Kim","last_name":"Solez","domain_name":"ualberta","page_name":"KimSolez","display_name":"Kim Solez","profile_url":"https://ualberta.academia.edu/KimSolez?f_ri=893785","photo":"https://0.academia-photos.com/2795255/2965120/53939542/s65_kim.solez.jpg"}</script></span></span></li><li class="js-paper-rank-work_2175783 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="2175783"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 2175783, container: ".js-paper-rank-work_2175783", }); 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Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":789977,"name":"Coronary Artery Disease","url":"https://www.academia.edu/Documents/in/Coronary_Artery_Disease?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":906219,"name":"Coronary artery bypass surgery","url":"https://www.academia.edu/Documents/in/Coronary_artery_bypass_surgery?f_ri=893785"},{"id":1000427,"name":"Reference Values","url":"https://www.academia.edu/Documents/in/Reference_Values?f_ri=893785"},{"id":1034177,"name":"Continuity of Patient Care","url":"https://www.academia.edu/Documents/in/Continuity_of_Patient_Care?f_ri=893785"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models?f_ri=893785"},{"id":1524625,"name":"Home Care Services","url":"https://www.academia.edu/Documents/in/Home_Care_Services?f_ri=893785"},{"id":1819400,"name":"Cohort 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We consistently detected high levels of JCV viremia, which correlated with the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24849889" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This is the first case of documented treatment failure of JCV nephritis, despite a reduction of immunosuppressive agents and the use of antiviral therapy. We consistently detected high levels of JCV viremia, which correlated with the progressive deterioration of the graft and caused the final loss of the kidney, suggesting that JCV plays an etiological role in the onset of severe nephropathy in kidney transplant patients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24849889" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c3b0f1fe8297cfd13a51d70e628e7c99" rel="nofollow" data-download="{"attachment_id":45173018,"asset_id":24849889,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45173018/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="47912021" href="https://independent.academia.edu/JeanRavetti">Jean Ravetti</a><script data-card-contents-for-user="47912021" type="text/json">{"id":47912021,"first_name":"Jean","last_name":"Ravetti","domain_name":"independent","page_name":"JeanRavetti","display_name":"Jean Ravetti","profile_url":"https://independent.academia.edu/JeanRavetti?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24849889 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24849889"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24849889, container: ".js-paper-rank-work_24849889", }); 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formulation for biopsy diagnosis of cardiac allograft rejection: The European experience</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of this study was to assess, at the European level and using digital technology, the inter-pathologist reproducibility of the ISHLT 2004 system and to compare it with the 1990 system We also assessed the reproducibility of the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13996013" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of this study was to assess, at the European level and using digital technology, the inter-pathologist reproducibility of the ISHLT 2004 system and to compare it with the 1990 system We also assessed the reproducibility of the morphologic criteria for diagnosis of antibodymediated rejection detailed in the 2004 grading system.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13996013" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="75b804c69fade93ae4c8e66c580bdac5" rel="nofollow" data-download="{"attachment_id":44720699,"asset_id":13996013,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44720699/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa 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The role of major histocompatibility complex class I antigens in tumorigenesis: future applications in cancer therapy. Auteur(s) / Author(s). NAPOLITANO L. (1) ; VOGEL J. ; JAY G. ; Affiliation(s) du ou des auteurs / Author(s)... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20924401" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">... The role of major histocompatibility complex class I antigens in tumorigenesis: future applications in cancer therapy. Auteur(s) / Author(s). NAPOLITANO L. (1) ; VOGEL J. ; JAY G. ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s). ... Tumor. ; Antígeno histocompatibilidad clase ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20924401" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="524174d13c6dc287ae1d32a5b15c55b4" rel="nofollow" data-download="{"attachment_id":41917533,"asset_id":20924401,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41917533/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33297897" href="https://ucsf.academia.edu/ScottZamvil">Scott Zamvil</a><script data-card-contents-for-user="33297897" type="text/json">{"id":33297897,"first_name":"Scott","last_name":"Zamvil","domain_name":"ucsf","page_name":"ScottZamvil","display_name":"Scott Zamvil","profile_url":"https://ucsf.academia.edu/ScottZamvil?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_20924401 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20924401"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20924401, container: ".js-paper-rank-work_20924401", }); 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Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation?f_ri=893785"},{"id":1792514,"name":"Antigen presenting cells","url":"https://www.academia.edu/Documents/in/Antigen_presenting_cells?f_ri=893785"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=893785"},{"id":2039739,"name":"Down-Regulation","url":"https://www.academia.edu/Documents/in/Down-Regulation?f_ri=893785"},{"id":2058663,"name":"Interferon gamma","url":"https://www.academia.edu/Documents/in/Interferon_gamma?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17591503" data-work_id="17591503" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17591503/Inferior_long_term_outcome_of_liver_kidney_transplantation_from_donation_after_cardiac_death_donors_Single_center_and_OPTN_analyses">Inferior long term outcome of liver-kidney transplantation from donation after cardiac death donors: Single center and OPTN analyses</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Limited data are available for outcomes of simultaneous liver-kidney (SLK) transplantation using donation after cardiac death (DCD) donors. The outcomes of 12 DCD-SLK transplants and 54 SLK transplants using donation after brain death... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17591503" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Limited data are available for outcomes of simultaneous liver-kidney (SLK) transplantation using donation after cardiac death (DCD) donors. The outcomes of 12 DCD-SLK transplants and 54 SLK transplants using donation after brain death (DBD) donors were retrospectively compared. The baseline demographics were similar for the DCD-SLK and DBD-SLK groups except for the higher liver donor risk index for the DCD-SLK group (1.8 6 0.4 versus 1.3 6 0.4, P 5 0.001). The rates of surgical complications and graft rejections within 1 year were comparable for the DCD-SLK and DBD-SLK groups. Delayed renal graft function was twice as common in the DCD-SLK group. At 1 year, the serum creatinine levels and the iothalamate glomerular filtration rates were similar for the groups. The patient, liver graft, and kidney graft survival rates at 1 year were comparable for the groups (83.3%, 75.0%, and 82.5% for the DCD-SLK group and 92.4%, 92.4%, and 92.6% for the DBD-SLK group, P 5 0.3 for all). The DCD-SLK group had worse patient, liver graft, and kidney graft survival at 3 years (62.5%, 62.5%, and 58.9% versus 90.5%, 90.5%, and 90.6%, P 5 0.03 for all) and at 5 years (62.5%, 62.5%, and 58.9% versus 87.4%, 87.4%, and 87.7%, P < 0.05 for all). An analysis of the Organ Procurement and Transplantation Network database showed inferior 1-and 5-year patient and graft survival rates for DCD-SLK patients versus DBD-SLK patients. In conclusion, despite comparable rates of surgical and medical complications and comparable kidney function at 1 year, DCD-SLK transplantation was associated with inferior long-term survival in comparison with DBD-SLK transplantation.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17591503" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f58bdb27ea756c04c183089eb946abf7" rel="nofollow" data-download="{"attachment_id":39600270,"asset_id":17591503,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39600270/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37425114" href="https://independent.academia.edu/HaniWadei">Hani Wadei</a><script data-card-contents-for-user="37425114" type="text/json">{"id":37425114,"first_name":"Hani","last_name":"Wadei","domain_name":"independent","page_name":"HaniWadei","display_name":"Hani Wadei","profile_url":"https://independent.academia.edu/HaniWadei?f_ri=893785","photo":"https://0.academia-photos.com/37425114/17927184/17941217/s65_hani.wadei.jpg"}</script></span></span></li><li class="js-paper-rank-work_17591503 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17591503"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17591503, container: ".js-paper-rank-work_17591503", }); 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The outcomes of 12 DCD-SLK transplants and 54 SLK transplants using donation after brain death (DBD) donors were retrospectively compared. The baseline demographics were similar for the DCD-SLK and DBD-SLK groups except for the higher liver donor risk index for the DCD-SLK group (1.8 6 0.4 versus 1.3 6 0.4, P 5 0.001). The rates of surgical complications and graft rejections within 1 year were comparable for the DCD-SLK and DBD-SLK groups. Delayed renal graft function was twice as common in the DCD-SLK group. At 1 year, the serum creatinine levels and the iothalamate glomerular filtration rates were similar for the groups. The patient, liver graft, and kidney graft survival rates at 1 year were comparable for the groups (83.3%, 75.0%, and 82.5% for the DCD-SLK group and 92.4%, 92.4%, and 92.6% for the DBD-SLK group, P 5 0.3 for all). The DCD-SLK group had worse patient, liver graft, and kidney graft survival at 3 years (62.5%, 62.5%, and 58.9% versus 90.5%, 90.5%, and 90.6%, P 5 0.03 for all) and at 5 years (62.5%, 62.5%, and 58.9% versus 87.4%, 87.4%, and 87.7%, P \u003c 0.05 for all). An analysis of the Organ Procurement and Transplantation Network database showed inferior 1-and 5-year patient and graft survival rates for DCD-SLK patients versus DBD-SLK patients. In conclusion, despite comparable rates of surgical and medical complications and comparable kidney function at 1 year, DCD-SLK transplantation was associated with inferior long-term survival in comparison with DBD-SLK transplantation.","downloadable_attachments":[{"id":39600270,"asset_id":17591503,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37425114,"first_name":"Hani","last_name":"Wadei","domain_name":"independent","page_name":"HaniWadei","display_name":"Hani Wadei","profile_url":"https://independent.academia.edu/HaniWadei?f_ri=893785","photo":"https://0.academia-photos.com/37425114/17927184/17941217/s65_hani.wadei.jpg"}],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true},{"id":45951,"name":"Brain Death","url":"https://www.academia.edu/Documents/in/Brain_Death?f_ri=893785","nofollow":true},{"id":110287,"name":"Florida","url":"https://www.academia.edu/Documents/in/Florida?f_ri=893785","nofollow":true},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation?f_ri=893785"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=893785"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=893785"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=893785"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1663285,"name":"Delayed graft function","url":"https://www.academia.edu/Documents/in/Delayed_graft_function?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_29621534" data-work_id="29621534" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/29621534/Donor_bone_marrow_infusion_in_simultaneous_pancreas_kidney_transplant_recipients_a_preliminary_study">Donor bone marrow infusion in simultaneous pancreas/kidney transplant recipients: a preliminary study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A rejection occurs commonly in simultaneous pancreas/kidney (SPK) transplant recipients and continues to be a cause of graft loss despite the potent immunosuppressive agents available. The induction of peripheral tolerance via bone marrow... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_29621534" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A rejection occurs commonly in simultaneous pancreas/kidney (SPK) transplant recipients and continues to be a cause of graft loss despite the potent immunosuppressive agents available. The induction of peripheral tolerance via bone marrow (BM) infusion has been successful in experimental animals. In the 1960s and 197Os, Anthony P. Monaco pioneered the concept of the establishment of a hematopoietic chimera to set the stage for a state of tolerance toward allogeneic transplants (skin, vascularized whole organ, etc) experimentally.'</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/29621534" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="71979d4f41994233c3d65d242d83e8e1" rel="nofollow" data-download="{"attachment_id":50060692,"asset_id":29621534,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50060692/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35601055" href="https://miami.academia.edu/GeorgeBurke">George Burke</a><script data-card-contents-for-user="35601055" type="text/json">{"id":35601055,"first_name":"George","last_name":"Burke","domain_name":"miami","page_name":"GeorgeBurke","display_name":"George Burke","profile_url":"https://miami.academia.edu/GeorgeBurke?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_29621534 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="29621534"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 29621534, container: ".js-paper-rank-work_29621534", }); 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The induction of peripheral tolerance via bone marrow (BM) infusion has been successful in experimental animals. In the 1960s and 197Os, Anthony P. Monaco pioneered the concept of the establishment of a hematopoietic chimera to set the stage for a state of tolerance toward allogeneic transplants (skin, vascularized whole organ, etc) experimentally.'","downloadable_attachments":[{"id":50060692,"asset_id":29621534,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35601055,"first_name":"George","last_name":"Burke","domain_name":"miami","page_name":"GeorgeBurke","display_name":"George Burke","profile_url":"https://miami.academia.edu/GeorgeBurke?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9003,"name":"Kidney 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patients in the early postoperative state of renal transplantation?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">All numbers indicate x100/L, except for ratio of CD4/CD8. *P Ͻ .05 increased vs the level of day Ϫ1. † P Ͻ .05 decreased vs the level of day Ϫ1.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25115278" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4c206ad5cdf6ebfcc2ad1deadce49260" rel="nofollow" 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distribution of circulating CD4+CD28+, CD4+CD25+ T lymphocytes indicate subclinical rejection in patients in the early postoperative state of renal transplantation?","created_at":"2016-05-07T16:06:12.667-07:00","url":"https://www.academia.edu/25115278/Does_the_distribution_of_circulating_CD4_CD28_CD4_CD25_T_lymphocytes_indicate_subclinical_rejection_in_patients_in_the_early_postoperative_state_of_renal_transplantation?f_ri=893785","dom_id":"work_25115278","summary":"All numbers indicate x100/L, except for ratio of CD4/CD8. *P Ͻ .05 increased vs the level of day Ϫ1. † P Ͻ .05 decreased vs the level of day Ϫ1.","downloadable_attachments":[{"id":45434154,"asset_id":25115278,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":48386114,"first_name":"Naotake","last_name":"Shimoda","domain_name":"independent","page_name":"NaotakeShimoda","display_name":"Naotake 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} })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13814054" data-work_id="13814054" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13814054/Structure_and_function_of_major_histocompatibility_complex_MHC_class_I_specific_receptors_expressed_on_human_natural_killer_NK_cells">Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Natural killer (NK) cells express receptors that are specific for MHC class I molecules. These receptors play a crucial role in regulating the lytic and cytokine expression capabilities of NK cells. In humans, three distinct families of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13814054" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Natural killer (NK) cells express receptors that are specific for MHC class I molecules. These receptors play a crucial role in regulating the lytic and cytokine expression capabilities of NK cells. In humans, three distinct families of genes have been defined that encode for receptors of HLA class I molecules. The first family identified consists of type I transmembrane molecules belonging to the immunoglobulin (Ig) superfamily and are called killer cell Ig-like receptors (KIR). A second group of receptors belonging to the Ig superfamily, named ILT (for immunoglobulin like transcripts), has more recently been described. ILTs are expressed mainly on B, T and myeloid cells, but some members of this group are also expressed on NK cells. They are also referred to as LIRs (for leukocyte Ig-like receptor) and MIRs (for macrophage Ig-like receptor). The ligands for the KIR and some of the ILT receptors include classical (class Ia) HLA class I molecules, as well as the nonclassical (class Ib) HLA-G molecule. The third family of HLA class I receptors are C-type lectin family members and are composed of heterodimers of CD94 covalently associated with a member of the NKG2 family of molecules. The ligand for most members is the nonclassical class I molecule HLA-E. NKG2D, a member of the NKG2 family, is expressed as a homodimer, along with the adaptor molecule DAP10. The ligands of NKG2D include the human class I like molecules MICA and MICB, and the recently described ULBPs. Each of these three families of receptors has individual members that can recognize identical or similar ligands yet signal for activation or inhibition of cellular functions. This dichotomy correlates with particular structural features present in the transmembrane and intracytoplasmic portions of these molecules.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13814054" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="700d5866348ba8d8b3fd435ed9212990" rel="nofollow" data-download="{"attachment_id":44920596,"asset_id":13814054,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44920596/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32912433" href="https://uco-es.academia.edu/RafaelSolana">Rafael Solana</a><script data-card-contents-for-user="32912433" type="text/json">{"id":32912433,"first_name":"Rafael","last_name":"Solana","domain_name":"uco-es","page_name":"RafaelSolana","display_name":"Rafael Solana","profile_url":"https://uco-es.academia.edu/RafaelSolana?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13814054 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13814054"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13814054, container: ".js-paper-rank-work_13814054", }); 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These receptors play a crucial role in regulating the lytic and cytokine expression capabilities of NK cells. In humans, three distinct families of genes have been defined that encode for receptors of HLA class I molecules. The first family identified consists of type I transmembrane molecules belonging to the immunoglobulin (Ig) superfamily and are called killer cell Ig-like receptors (KIR). A second group of receptors belonging to the Ig superfamily, named ILT (for immunoglobulin like transcripts), has more recently been described. ILTs are expressed mainly on B, T and myeloid cells, but some members of this group are also expressed on NK cells. They are also referred to as LIRs (for leukocyte Ig-like receptor) and MIRs (for macrophage Ig-like receptor). The ligands for the KIR and some of the ILT receptors include classical (class Ia) HLA class I molecules, as well as the nonclassical (class Ib) HLA-G molecule. The third family of HLA class I receptors are C-type lectin family members and are composed of heterodimers of CD94 covalently associated with a member of the NKG2 family of molecules. The ligand for most members is the nonclassical class I molecule HLA-E. NKG2D, a member of the NKG2 family, is expressed as a homodimer, along with the adaptor molecule DAP10. The ligands of NKG2D include the human class I like molecules MICA and MICB, and the recently described ULBPs. Each of these three families of receptors has individual members that can recognize identical or similar ligands yet signal for activation or inhibition of cellular functions. This dichotomy correlates with particular structural features present in the transmembrane and intracytoplasmic portions of these molecules.","downloadable_attachments":[{"id":44920596,"asset_id":13814054,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32912433,"first_name":"Rafael","last_name":"Solana","domain_name":"uco-es","page_name":"RafaelSolana","display_name":"Rafael Solana","profile_url":"https://uco-es.academia.edu/RafaelSolana?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=893785","nofollow":true},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=893785","nofollow":true},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=893785","nofollow":true},{"id":49646,"name":"Protein Structure and Function","url":"https://www.academia.edu/Documents/in/Protein_Structure_and_Function?f_ri=893785","nofollow":true},{"id":50157,"name":"Molecular","url":"https://www.academia.edu/Documents/in/Molecular?f_ri=893785"},{"id":63332,"name":"Molecular Immunology","url":"https://www.academia.edu/Documents/in/Molecular_Immunology?f_ri=893785"},{"id":70247,"name":"Natural Killer cells","url":"https://www.academia.edu/Documents/in/Natural_Killer_cells?f_ri=893785"},{"id":73608,"name":"Human nature","url":"https://www.academia.edu/Documents/in/Human_nature?f_ri=893785"},{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression?f_ri=893785"},{"id":435727,"name":"Major histocompatibility complex","url":"https://www.academia.edu/Documents/in/Major_histocompatibility_complex?f_ri=893785"},{"id":653665,"name":"Protein Conformation","url":"https://www.academia.edu/Documents/in/Protein_Conformation?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship?f_ri=893785"},{"id":1222191,"name":"Ligands","url":"https://www.academia.edu/Documents/in/Ligands?f_ri=893785"},{"id":1274831,"name":"NK Cell","url":"https://www.academia.edu/Documents/in/NK_Cell?f_ri=893785"},{"id":1330386,"name":"MHC class I","url":"https://www.academia.edu/Documents/in/MHC_class_I?f_ri=893785"},{"id":1426712,"name":"Immunoglobulin","url":"https://www.academia.edu/Documents/in/Immunoglobulin?f_ri=893785"},{"id":1724844,"name":"Molecular Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22830455" data-work_id="22830455" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22830455/The_case_for_selective_re_issuance_of_medical_certificates_to_allow_pilots_who_have_received_a_heart_transplant_to_resume_flying">The case for selective re-issuance of medical certificates to allow pilots who have received a heart transplant to resume flying</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Cardiac transplant recipients have been regarded as not medically fit to fly an airplane. Recently, the Federal Aviation Administration decided to re-examine this policy and, in response, this study was undertaken to determine... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22830455" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Cardiac transplant recipients have been regarded as not medically fit to fly an airplane. Recently, the Federal Aviation Administration decided to re-examine this policy and, in response, this study was undertaken to determine the risk of death from any cause and sudden-onset death in heart transplant recipients during the 12 months after an annual evaluation.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22830455" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c9a12c41574c9688b52184ecb0c51d8a" rel="nofollow" data-download="{"attachment_id":43375314,"asset_id":22830455,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43375314/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="44480903" href="https://independent.academia.edu/BClemson">Barry Clemson</a><script data-card-contents-for-user="44480903" type="text/json">{"id":44480903,"first_name":"Barry","last_name":"Clemson","domain_name":"independent","page_name":"BClemson","display_name":"Barry Clemson","profile_url":"https://independent.academia.edu/BClemson?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22830455 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22830455"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22830455, container: ".js-paper-rank-work_22830455", }); 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Recently, the Federal Aviation Administration decided to re-examine this policy and, in response, this study was undertaken to determine the risk of death from any cause and sudden-onset death in heart transplant recipients during the 12 months after an annual evaluation.","downloadable_attachments":[{"id":43375314,"asset_id":22830455,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":44480903,"first_name":"Barry","last_name":"Clemson","domain_name":"independent","page_name":"BClemson","display_name":"Barry Clemson","profile_url":"https://independent.academia.edu/BClemson?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=893785","nofollow":true},{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=893785","nofollow":true},{"id":72128,"name":"Aerospace 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Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":487159,"name":"Group","url":"https://www.academia.edu/Documents/in/Group?f_ri=893785"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=893785"},{"id":708740,"name":"Hazard Analysis","url":"https://www.academia.edu/Documents/in/Hazard_Analysis?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":922329,"name":"Hazard Rate","url":"https://www.academia.edu/Documents/in/Hazard_Rate?f_ri=893785"},{"id":972948,"name":"Stepwise Regression","url":"https://www.academia.edu/Documents/in/Stepwise_Regression?f_ri=893785"},{"id":1198588,"name":"Cyclophosphamide","url":"https://www.academia.edu/Documents/in/Cyclophosphamide?f_ri=893785"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18745277" data-work_id="18745277" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18745277/Lower_Incidence_of_Liver_Graft_Rejection_in_Patients_on_Diltiazem_Plus_Cyclosporine_Therapy">Lower Incidence of Liver Graft Rejection in Patients on Diltiazem Plus Cyclosporine Therapy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">C YCLOSPORINE (Cs) is the main immunosuppressive drug used in organ transplantation. However, its use often produces arterial hypertension and nephrotoxicity. 1,2 Diltiazem (DTZ), a calcium channel blocker (CCB) of the benzothiapene... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18745277" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">C YCLOSPORINE (Cs) is the main immunosuppressive drug used in organ transplantation. However, its use often produces arterial hypertension and nephrotoxicity. 1,2 Diltiazem (DTZ), a calcium channel blocker (CCB) of the benzothiapene class, minimizes these side effects. 3 Cs decreases the renal blood flow and, consequently, the glomerular filtration rate, and DTZ counteracts this effect protecting the renal function. 4 Moreover, DTZ has antihypertensive and anti-atherogenic properties. 1 Additionally, DTZ has an inhibitory effect on the Cs metabolism by hepatic cytochrome P450 enzymes increasing Cs blood levels, which allows a reduction in the Cs dose ranging from 20% to 50%. A lower incidence of graft rejection has been reported with the association of CCB and Cs in renal and cardiac transplantation. 3,5 There are, however, no known studies on that effect in liver transplantation (LTx).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18745277" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b118aa5f2c077d24e54203ff8b07b222" rel="nofollow" data-download="{"attachment_id":40232356,"asset_id":18745277,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40232356/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38818025" href="https://usp-br.academia.edu/SMies">S. Mies</a><script data-card-contents-for-user="38818025" type="text/json">{"id":38818025,"first_name":"S.","last_name":"Mies","domain_name":"usp-br","page_name":"SMies","display_name":"S. 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However, its use often produces arterial hypertension and nephrotoxicity. 1,2 Diltiazem (DTZ), a calcium channel blocker (CCB) of the benzothiapene class, minimizes these side effects. 3 Cs decreases the renal blood flow and, consequently, the glomerular filtration rate, and DTZ counteracts this effect protecting the renal function. 4 Moreover, DTZ has antihypertensive and anti-atherogenic properties. 1 Additionally, DTZ has an inhibitory effect on the Cs metabolism by hepatic cytochrome P450 enzymes increasing Cs blood levels, which allows a reduction in the Cs dose ranging from 20% to 50%. A lower incidence of graft rejection has been reported with the association of CCB and Cs in renal and cardiac transplantation. 3,5 There are, however, no known studies on that effect in liver transplantation (LTx).","downloadable_attachments":[{"id":40232356,"asset_id":18745277,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38818025,"first_name":"S.","last_name":"Mies","domain_name":"usp-br","page_name":"SMies","display_name":"S. Mies","profile_url":"https://usp-br.academia.edu/SMies?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=893785","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=893785","nofollow":true},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation?f_ri=893785","nofollow":true},{"id":168352,"name":"Cyclosporine","url":"https://www.academia.edu/Documents/in/Cyclosporine?f_ri=893785","nofollow":true},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=893785"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=893785"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1954221,"name":"Calcium Channel Blockers","url":"https://www.academia.edu/Documents/in/Calcium_Channel_Blockers?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18425350" data-work_id="18425350" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18425350/Cyclosporine_Sparing_with_Mycophenolate_Mofetil_Daclizumab_and_Corticosteroids_in_Renal_Allograft_Recipients_The_CAESAR_Study">Cyclosporine Sparing with Mycophenolate Mofetil, Daclizumab and Corticosteroids in Renal Allograft Recipients: The CAESAR Study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Although the calcineurin inhibitors (CNI) cyclosporine (CsA) and tacrolimus are highly effective immunosuppressants, they are associated with serious side effects. There is great interest in immunosuppressive regimens that permit... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18425350" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Although the calcineurin inhibitors (CNI) cyclosporine (CsA) and tacrolimus are highly effective immunosuppressants, they are associated with serious side effects. There is great interest in immunosuppressive regimens that permit reduction or elimination of CNIs, while maintaining adequate immunosuppression and acceptable acute rejection rates. Patients (n = 536) receiving their first renal allograft were randomized to one of three immunosuppressant regimens: daclizumab, mycophenolate mofetil (MMF), corticosteroids (CS) and low-dose CsA (target trough levels of 50-100 ng/mL), weaned from month 4 and withdrawn by month 6; daclizumab, MMF, CS and low-dose CsA; or MMF, CS and standard-dose CsA. Mean GFR 12 months after transplantation (primary end point) was not statistically different in the CsA withdrawal and low-dose CsA groups (both 50.9 mL/min/1.73 m(2)) vs. the standard-dose CsA group (48.6 mL/min/1.73 m(2)). At 12 months, the incidence of biopsy-proven acute rejection was significantly higher in the CsA withdrawal group (38%) vs. the low- or standard-dose CsA groups (25.4% and 27.5%, respectively; p &amp;lt; 0.05). In summary, a regimen of continuous low-dose CsA with MMF, CS and daclizumab induction is a clinically safe and effective immunosuppressive regimen in renal transplant recipients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18425350" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="58c4713cbe2d63dade444e76c2dfc214" rel="nofollow" data-download="{"attachment_id":42170176,"asset_id":18425350,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42170176/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38431552" href="https://independent.academia.edu/JosepGrinyo">Josep Grinyo</a><script data-card-contents-for-user="38431552" type="text/json">{"id":38431552,"first_name":"Josep","last_name":"Grinyo","domain_name":"independent","page_name":"JosepGrinyo","display_name":"Josep Grinyo","profile_url":"https://independent.academia.edu/JosepGrinyo?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18425350 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18425350"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18425350, container: ".js-paper-rank-work_18425350", }); 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$(".js-view-count[data-work-id=18425350]").text(description); $(".js-view-count-work_18425350").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18425350").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18425350"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9003" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_transplantation">Kidney transplantation</a>, <script data-card-contents-for-ri="9003" type="text/json">{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="118540" rel="nofollow" href="https://www.academia.edu/Documents/in/Immunosuppression">Immunosuppression</a><script data-card-contents-for-ri="118540" type="text/json">{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18425350]'), work: {"id":18425350,"title":"Cyclosporine Sparing with Mycophenolate Mofetil, Daclizumab and Corticosteroids in Renal Allograft Recipients: The CAESAR Study","created_at":"2015-11-16T02:02:31.173-08:00","url":"https://www.academia.edu/18425350/Cyclosporine_Sparing_with_Mycophenolate_Mofetil_Daclizumab_and_Corticosteroids_in_Renal_Allograft_Recipients_The_CAESAR_Study?f_ri=893785","dom_id":"work_18425350","summary":"Although the calcineurin inhibitors (CNI) cyclosporine (CsA) and tacrolimus are highly effective immunosuppressants, they are associated with serious side effects. There is great interest in immunosuppressive regimens that permit reduction or elimination of CNIs, while maintaining adequate immunosuppression and acceptable acute rejection rates. Patients (n = 536) receiving their first renal allograft were randomized to one of three immunosuppressant regimens: daclizumab, mycophenolate mofetil (MMF), corticosteroids (CS) and low-dose CsA (target trough levels of 50-100 ng/mL), weaned from month 4 and withdrawn by month 6; daclizumab, MMF, CS and low-dose CsA; or MMF, CS and standard-dose CsA. Mean GFR 12 months after transplantation (primary end point) was not statistically different in the CsA withdrawal and low-dose CsA groups (both 50.9 mL/min/1.73 m(2)) vs. the standard-dose CsA group (48.6 mL/min/1.73 m(2)). At 12 months, the incidence of biopsy-proven acute rejection was significantly higher in the CsA withdrawal group (38%) vs. the low- or standard-dose CsA groups (25.4% and 27.5%, respectively; p \u0026amp;lt; 0.05). In summary, a regimen of continuous low-dose CsA with MMF, CS and daclizumab induction is a clinically safe and effective immunosuppressive regimen in renal transplant recipients.","downloadable_attachments":[{"id":42170176,"asset_id":18425350,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38431552,"first_name":"Josep","last_name":"Grinyo","domain_name":"independent","page_name":"JosepGrinyo","display_name":"Josep Grinyo","profile_url":"https://independent.academia.edu/JosepGrinyo?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=893785","nofollow":true},{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression?f_ri=893785","nofollow":true},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies?f_ri=893785"},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American?f_ri=893785"},{"id":168352,"name":"Cyclosporine","url":"https://www.academia.edu/Documents/in/Cyclosporine?f_ri=893785"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=893785"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G?f_ri=893785"},{"id":1740530,"name":"Mycophenolate mofetil","url":"https://www.academia.edu/Documents/in/Mycophenolate_mofetil?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_32308770" data-work_id="32308770" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/32308770/ACL_graft_re_rupture_after_double_bundle_reconstruction_factors_that_influence_the_intra_articular_pattern_of_injury">ACL graft re-rupture after double-bundle reconstruction: factors that influence the intra-articular pattern of injury</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose To determine the most common rupture patterns of previously reconstructed DB-ACL cases, seen at the time of revision surgery, and to determine the influence of age, gender, time between the initial ACL reconstruction and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_32308770" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose To determine the most common rupture patterns of previously reconstructed DB-ACL cases, seen at the time of revision surgery, and to determine the influence of age, gender, time between the initial ACL reconstruction and re-injury, tunnel angle and etiology of failure. Methods Forty patients who presented for revision surgery after previous double-bundle ACL reconstruction were enrolled. Three orthopedic surgeons independently reviewed the arthroscopic videos and determined the rupture pattern of both the anteromedial and posterolateral grafts. The graft rupture pattern was then correlated with the previously mentioned factors.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/32308770" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a39356af9494eb9994256826c627c84b" rel="nofollow" data-download="{"attachment_id":52522235,"asset_id":32308770,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/52522235/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="62618937" href="https://independent.academia.edu/FreddieFu">Freddie Fu</a><script data-card-contents-for-user="62618937" type="text/json">{"id":62618937,"first_name":"Freddie","last_name":"Fu","domain_name":"independent","page_name":"FreddieFu","display_name":"Freddie Fu","profile_url":"https://independent.academia.edu/FreddieFu?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_32308770 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="32308770"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 32308770, container: ".js-paper-rank-work_32308770", }); });</script></li><li class="js-percentile-work_32308770 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 32308770; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_32308770"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_32308770 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="32308770"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 32308770; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=32308770]").text(description); $(".js-view-count-work_32308770").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_32308770").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="32308770"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3243" rel="nofollow" href="https://www.academia.edu/Documents/in/Nonparametric_Statistics">Nonparametric Statistics</a>, <script data-card-contents-for-ri="3243" type="text/json">{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="48627" rel="nofollow" href="https://www.academia.edu/Documents/in/Anterior_Cruciate_Ligament">Anterior Cruciate Ligament</a><script data-card-contents-for-ri="48627" type="text/json">{"id":48627,"name":"Anterior Cruciate Ligament","url":"https://www.academia.edu/Documents/in/Anterior_Cruciate_Ligament?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=32308770]'), work: {"id":32308770,"title":"ACL graft re-rupture after double-bundle reconstruction: factors that influence the intra-articular pattern of injury","created_at":"2017-04-06T20:56:25.731-07:00","url":"https://www.academia.edu/32308770/ACL_graft_re_rupture_after_double_bundle_reconstruction_factors_that_influence_the_intra_articular_pattern_of_injury?f_ri=893785","dom_id":"work_32308770","summary":"Purpose To determine the most common rupture patterns of previously reconstructed DB-ACL cases, seen at the time of revision surgery, and to determine the influence of age, gender, time between the initial ACL reconstruction and re-injury, tunnel angle and etiology of failure. Methods Forty patients who presented for revision surgery after previous double-bundle ACL reconstruction were enrolled. Three orthopedic surgeons independently reviewed the arthroscopic videos and determined the rupture pattern of both the anteromedial and posterolateral grafts. The graft rupture pattern was then correlated with the previously mentioned factors.","downloadable_attachments":[{"id":52522235,"asset_id":32308770,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":62618937,"first_name":"Freddie","last_name":"Fu","domain_name":"independent","page_name":"FreddieFu","display_name":"Freddie Fu","profile_url":"https://independent.academia.edu/FreddieFu?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=893785","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=893785","nofollow":true},{"id":48627,"name":"Anterior Cruciate Ligament","url":"https://www.academia.edu/Documents/in/Anterior_Cruciate_Ligament?f_ri=893785","nofollow":true},{"id":118122,"name":"Arthroscopy","url":"https://www.academia.edu/Documents/in/Arthroscopy?f_ri=893785"},{"id":129744,"name":"Confidence intervals","url":"https://www.academia.edu/Documents/in/Confidence_intervals?f_ri=893785"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=893785"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=893785"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=893785"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=893785"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785"},{"id":423007,"name":"Knee injuries","url":"https://www.academia.edu/Documents/in/Knee_injuries?f_ri=893785"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=893785"},{"id":584601,"name":"Chi Square Distribution","url":"https://www.academia.edu/Documents/in/Chi_Square_Distribution?f_ri=893785"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1540546,"name":"Video Recording","url":"https://www.academia.edu/Documents/in/Video_Recording?f_ri=893785"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=893785"},{"id":2482067,"name":"Reoperation","url":"https://www.academia.edu/Documents/in/Reoperation?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_30665323" data-work_id="30665323" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30665323/The_Ross_Operation_in_Children_Effects_of_Aortic_Annuloplasty">The Ross Operation in Children: Effects of Aortic Annuloplasty</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background. Autograft dilatation and progressive neoaortic regurgitation after the Ross procedure prompted us to perform routine aortic annuloplasty. The purpose of this review is to evaluate the success of this technical modification in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_30665323" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background. Autograft dilatation and progressive neoaortic regurgitation after the Ross procedure prompted us to perform routine aortic annuloplasty. The purpose of this review is to evaluate the success of this technical modification in preventing autograft failure requiring reoperation.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30665323" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b30707620685a50ff4f7229126281340" rel="nofollow" data-download="{"attachment_id":51107697,"asset_id":30665323,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51107697/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="58407267" href="https://independent.academia.edu/HillmanNeal">Neal Hillman</a><script data-card-contents-for-user="58407267" type="text/json">{"id":58407267,"first_name":"Neal","last_name":"Hillman","domain_name":"independent","page_name":"HillmanNeal","display_name":"Neal Hillman","profile_url":"https://independent.academia.edu/HillmanNeal?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_30665323 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30665323"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30665323, container: ".js-paper-rank-work_30665323", }); 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Autograft dilatation and progressive neoaortic regurgitation after the Ross procedure prompted us to perform routine aortic annuloplasty. The purpose of this review is to evaluate the success of this technical modification in preventing autograft failure requiring reoperation.","downloadable_attachments":[{"id":51107697,"asset_id":30665323,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":58407267,"first_name":"Neal","last_name":"Hillman","domain_name":"independent","page_name":"HillmanNeal","display_name":"Neal Hillman","profile_url":"https://independent.academia.edu/HillmanNeal?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=893785","nofollow":true},{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment?f_ri=893785","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=893785","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=893785"},{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects?f_ri=893785"},{"id":62660,"name":"Cell and Tissue Transplantation","url":"https://www.academia.edu/Documents/in/Cell_and_Tissue_Transplantation?f_ri=893785"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=893785"},{"id":97450,"name":"Intervention","url":"https://www.academia.edu/Documents/in/Intervention?f_ri=893785"},{"id":102574,"name":"Thorax","url":"https://www.academia.edu/Documents/in/Thorax?f_ri=893785"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=893785"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=893785"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785"},{"id":249090,"name":"Operation","url":"https://www.academia.edu/Documents/in/Operation?f_ri=893785"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=893785"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=893785"},{"id":1929419,"name":"Nino","url":"https://www.academia.edu/Documents/in/Nino?f_ri=893785"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_29011929" data-work_id="29011929" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/29011929/Hypertension_after_kidney_transplantation">Hypertension after kidney transplantation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Few studies have examined the possible role of blood pressure (BP), independent of acute rejection and graft function, on outcomes after kidney transplantation. Methods: We investigated the prevalence, treatment, control, and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_29011929" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Few studies have examined the possible role of blood pressure (BP), independent of acute rejection and graft function, on outcomes after kidney transplantation. Methods: We investigated the prevalence, treatment, control, and clinical correlates of hypertension and its association with outcomes, using multivariate analyses with timedependent covariates, in a retrospective cohort of 1,666 kidney transplant recipients. Results: Hypertension was common, and its control was poor. For example, at 1 year, only 55.5% had a BP less than 140 mm Hg. Control improved only slightly in 1993-2002 compared to 1976-2002, even as patients administered 2 or more antihypertensive medications at 1 year increased from 43.5% to 54.6%. Independent correlates of higher BP included male sex, age, donor age, diabetes, body mass index, the presence of native kidneys, and delayed graft function. Previous acute rejection was associated with higher BP at virtually all times after transplantation, and these associations were independent of estimated creatinine clearance (C Cr ). Conversely, an association between BP and subsequent acute rejection was not statistically significant when differences in C Cr were taken into account. After adjusting for the effects of acute rejection, C Cr , and other variables, each 10 mm Hg of systolic BP was associated with an increased relative risk for graft failure (1.12; 95% confidence interval, 1.08 to 1.15; P < 0.0001), death-censored graft failure (1.17; 1.12 to 1.22; P < 0.0001), and death (1.18; 1.12 to 1.23; P < 0.0001). Conclusion: High BP is closely tied to graft function, but nevertheless is an independent risk factor for graft failure and mortality. Better strategies are needed to control BP after kidney transplantation. Am J Kidney Dis 43:1071-1081.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/29011929" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="79a7d723b729eb1785c9954389c2b8b2" rel="nofollow" data-download="{"attachment_id":49460555,"asset_id":29011929,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49460555/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="3447421" href="https://agriculture.academia.edu/ShakeelAhmadAnjum">Shakeel Ahmad Anjum</a><script data-card-contents-for-user="3447421" type="text/json">{"id":3447421,"first_name":"Shakeel Ahmad","last_name":"Anjum","domain_name":"agriculture","page_name":"ShakeelAhmadAnjum","display_name":"Shakeel Ahmad Anjum","profile_url":"https://agriculture.academia.edu/ShakeelAhmadAnjum?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_29011929 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="29011929"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 29011929, container: ".js-paper-rank-work_29011929", }); 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Methods: We investigated the prevalence, treatment, control, and clinical correlates of hypertension and its association with outcomes, using multivariate analyses with timedependent covariates, in a retrospective cohort of 1,666 kidney transplant recipients. Results: Hypertension was common, and its control was poor. For example, at 1 year, only 55.5% had a BP less than 140 mm Hg. Control improved only slightly in 1993-2002 compared to 1976-2002, even as patients administered 2 or more antihypertensive medications at 1 year increased from 43.5% to 54.6%. Independent correlates of higher BP included male sex, age, donor age, diabetes, body mass index, the presence of native kidneys, and delayed graft function. Previous acute rejection was associated with higher BP at virtually all times after transplantation, and these associations were independent of estimated creatinine clearance (C Cr ). Conversely, an association between BP and subsequent acute rejection was not statistically significant when differences in C Cr were taken into account. After adjusting for the effects of acute rejection, C Cr , and other variables, each 10 mm Hg of systolic BP was associated with an increased relative risk for graft failure (1.12; 95% confidence interval, 1.08 to 1.15; P \u003c 0.0001), death-censored graft failure (1.17; 1.12 to 1.22; P \u003c 0.0001), and death (1.18; 1.12 to 1.23; P \u003c 0.0001). Conclusion: High BP is closely tied to graft function, but nevertheless is an independent risk factor for graft failure and mortality. Better strategies are needed to control BP after kidney transplantation. Am J Kidney Dis 43:1071-1081.","downloadable_attachments":[{"id":49460555,"asset_id":29011929,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":3447421,"first_name":"Shakeel Ahmad","last_name":"Anjum","domain_name":"agriculture","page_name":"ShakeelAhmadAnjum","display_name":"Shakeel Ahmad Anjum","profile_url":"https://agriculture.academia.edu/ShakeelAhmadAnjum?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true},{"id":48936,"name":"TIME","url":"https://www.academia.edu/Documents/in/TIME?f_ri=893785","nofollow":true},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney?f_ri=893785","nofollow":true},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension?f_ri=893785"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus?f_ri=893785"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=893785"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=893785"},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American?f_ri=893785"},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index?f_ri=893785"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=893785"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=893785"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=893785"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=893785"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=893785"},{"id":621517,"name":"Time","url":"https://www.academia.edu/Documents/in/Time-2?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors?f_ri=893785"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_7260136" data-work_id="7260136" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/7260136/The_Effects_of_Rapamycin_in_Murine_Peripheral_Nerve_Isografts_and_Allografts">The Effects of Rapamycin in Murine Peripheral Nerve Isografts and Allografts</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The FKBP-12-binding ligand FK506 has been successfully used to stimulate nerve regeneration and prevent the rejection of peripheral nerve allografts. The immunosuppressant rapamycin, another FKBP-12-binding ligand, stimulates axonal... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_7260136" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The FKBP-12-binding ligand FK506 has been successfully used to stimulate nerve regeneration and prevent the rejection of peripheral nerve allografts. The immunosuppressant rapamycin, another FKBP-12-binding ligand, stimulates axonal regeneration in vitro, but its influence on nerve regeneration in peripheral nerve isografts or allografts has not been studied. Sixty female inbred BALB/cJ mice were randomized into six tibial nerve transplant groups, including three isograft and three allograft (C57BL/6J) groups. Grafts were left untreated (groups I and II), treated with FK506 (groups III and IV), or treated with rapamycin (groups V and VI). Nerve regeneration was quantified in terms of histomorphometry and functional recovery, and immunosuppression was confirmed with mixed lymphocyte reactivity assays. Animals treated with FK506 and rapamycin were immunosuppressed and demonstrated significantly less immune cell proliferation relative to untreated recipient animals. Although every animal demonstrated some functional recovery during the study, animals receiving an untreated peripheral nerve allograft were slowest to recover. Isografts treated with FK506 but not rapamycin demonstrated significantly increased nerve regeneration. Nerve allografts in animals treated with FK506, and to a lesser extent rapamycin, however, both demonstrated significantly more nerve regeneration and increased nerve fiber widths relative to untreated controls. The authors suggest that rapamycin can facilitate regeneration through peripheral nerve allografts, but it is not a neuroregenerative agent in this in vivo model. Nerve regeneration in FK506-treated peripheral nerve isografts and allografts was superior to that found in rapamycin-treated animals. Rapamycin may have a role in the treatment of peripheral nerve allografts when used in combination with other medications, or in the setting of renal failure that often precludes the use of calcineurin inhibitors such as FK506. (Plast. Reconstr. Surg. 109: 2405, 2002 Functional recovery following peripheral nerve injury is predicated on a robust and timely reinnervation of sensory receptors and motor end plates. 1-3 A reliable neuroregenera-tive agent with minimal systemic toxicity would hasten functional recovery following extensive proximal peripheral nerve injury. The immunosuppressant FK506 possesses a well-studied neuroregenerative effect, stimulating neurite extension in the presence of nerve growth factor in vitro, 4,5 and enhancing nerve regeneration in nerve crush, 5-8 transection, 7,9 isograft, 10,11 and allograft models. 12-14 FK506 has also been used to facilitate axonal regeneration through human peripheral nerve allografts. Given its immunosuppressive and calcineurin-related side effects, including renal failure 16 and hypertension, 17 the use of FK506 solely to stimulate nerve regeneration cannot be justified. The utility of FK506 in the context of preexisting composite tissue and peripheral nerve allograft tolerance has also been challenged. 18 Studies demonstrating successful transplantation of skin 19 and solid organ allografts using a monoclonal antibody to block the costimulatory pathway of T-cell activation demonstrated an almost immediate abrogation of these effects with the addition of a calcineurin inhibitor such as FK506. 19 -23 The inability of FK506 to coexist with novel tolerizing therapies such as anti-CD40L monoclonal antibody will have significant implication for clinical peripheral nerve and hand allotransplantation when the neuroregenerative effects of FK506 are desirable. Like FK506, rapamycin is an immunosuppressant that binds FKBP-12 and has demonstrated a neuroenhancing effect in vitro. 5,6,26 -30 To our knowledge, however, neither the in vivo</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7260136" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="cbb23521d3c48b063b55d58dacdb6510" rel="nofollow" data-download="{"attachment_id":48546827,"asset_id":7260136,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48546827/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12658288" href="https://independent.academia.edu/AaronsRamsey">Aarons Ramsey</a><script data-card-contents-for-user="12658288" type="text/json">{"id":12658288,"first_name":"Aarons","last_name":"Ramsey","domain_name":"independent","page_name":"AaronsRamsey","display_name":"Aarons Ramsey","profile_url":"https://independent.academia.edu/AaronsRamsey?f_ri=893785","photo":"https://0.academia-photos.com/12658288/3606475/4230700/s65_aarons.ramsey.jpg"}</script></span></span></li><li class="js-paper-rank-work_7260136 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="7260136"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 7260136, container: ".js-paper-rank-work_7260136", }); 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The immunosuppressant rapamycin, another FKBP-12-binding ligand, stimulates axonal regeneration in vitro, but its influence on nerve regeneration in peripheral nerve isografts or allografts has not been studied. Sixty female inbred BALB/cJ mice were randomized into six tibial nerve transplant groups, including three isograft and three allograft (C57BL/6J) groups. Grafts were left untreated (groups I and II), treated with FK506 (groups III and IV), or treated with rapamycin (groups V and VI). Nerve regeneration was quantified in terms of histomorphometry and functional recovery, and immunosuppression was confirmed with mixed lymphocyte reactivity assays. Animals treated with FK506 and rapamycin were immunosuppressed and demonstrated significantly less immune cell proliferation relative to untreated recipient animals. Although every animal demonstrated some functional recovery during the study, animals receiving an untreated peripheral nerve allograft were slowest to recover. Isografts treated with FK506 but not rapamycin demonstrated significantly increased nerve regeneration. Nerve allografts in animals treated with FK506, and to a lesser extent rapamycin, however, both demonstrated significantly more nerve regeneration and increased nerve fiber widths relative to untreated controls. The authors suggest that rapamycin can facilitate regeneration through peripheral nerve allografts, but it is not a neuroregenerative agent in this in vivo model. Nerve regeneration in FK506-treated peripheral nerve isografts and allografts was superior to that found in rapamycin-treated animals. Rapamycin may have a role in the treatment of peripheral nerve allografts when used in combination with other medications, or in the setting of renal failure that often precludes the use of calcineurin inhibitors such as FK506. (Plast. Reconstr. Surg. 109: 2405, 2002 Functional recovery following peripheral nerve injury is predicated on a robust and timely reinnervation of sensory receptors and motor end plates. 1-3 A reliable neuroregenera-tive agent with minimal systemic toxicity would hasten functional recovery following extensive proximal peripheral nerve injury. The immunosuppressant FK506 possesses a well-studied neuroregenerative effect, stimulating neurite extension in the presence of nerve growth factor in vitro, 4,5 and enhancing nerve regeneration in nerve crush, 5-8 transection, 7,9 isograft, 10,11 and allograft models. 12-14 FK506 has also been used to facilitate axonal regeneration through human peripheral nerve allografts. Given its immunosuppressive and calcineurin-related side effects, including renal failure 16 and hypertension, 17 the use of FK506 solely to stimulate nerve regeneration cannot be justified. The utility of FK506 in the context of preexisting composite tissue and peripheral nerve allograft tolerance has also been challenged. 18 Studies demonstrating successful transplantation of skin 19 and solid organ allografts using a monoclonal antibody to block the costimulatory pathway of T-cell activation demonstrated an almost immediate abrogation of these effects with the addition of a calcineurin inhibitor such as FK506. 19 -23 The inability of FK506 to coexist with novel tolerizing therapies such as anti-CD40L monoclonal antibody will have significant implication for clinical peripheral nerve and hand allotransplantation when the neuroregenerative effects of FK506 are desirable. Like FK506, rapamycin is an immunosuppressant that binds FKBP-12 and has demonstrated a neuroenhancing effect in vitro. 5,6,26 -30 To our knowledge, however, neither the in vivo","downloadable_attachments":[{"id":48546827,"asset_id":7260136,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":12658288,"first_name":"Aarons","last_name":"Ramsey","domain_name":"independent","page_name":"AaronsRamsey","display_name":"Aarons Ramsey","profile_url":"https://independent.academia.edu/AaronsRamsey?f_ri=893785","photo":"https://0.academia-photos.com/12658288/3606475/4230700/s65_aarons.ramsey.jpg"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=893785","nofollow":true},{"id":9658,"name":"Locomotion","url":"https://www.academia.edu/Documents/in/Locomotion?f_ri=893785","nofollow":true},{"id":53714,"name":"Plastic and Reconstructive Surgery","url":"https://www.academia.edu/Documents/in/Plastic_and_Reconstructive_Surgery?f_ri=893785","nofollow":true},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus?f_ri=893785","nofollow":true},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=893785"},{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression?f_ri=893785"},{"id":130538,"name":"Plastic","url":"https://www.academia.edu/Documents/in/Plastic?f_ri=893785"},{"id":243672,"name":"Nerve Regeneration","url":"https://www.academia.edu/Documents/in/Nerve_Regeneration?f_ri=893785"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785"},{"id":396873,"name":"And","url":"https://www.academia.edu/Documents/in/And?f_ri=893785"},{"id":509434,"name":"Peripheral Nerve","url":"https://www.academia.edu/Documents/in/Peripheral_Nerve?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1150115,"name":"Sirolimus","url":"https://www.academia.edu/Documents/in/Sirolimus?f_ri=893785"},{"id":2245217,"name":"Tibial nerve","url":"https://www.academia.edu/Documents/in/Tibial_nerve?f_ri=893785"},{"id":2474622,"name":"Recovery of Function","url":"https://www.academia.edu/Documents/in/Recovery_of_Function?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10103482" data-work_id="10103482" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10103482/Leeches_Immune_Response_Angiogenesis_and_Biomedical_Applications">Leeches: Immune Response, Angiogenesis and Biomedical Applications</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The innate immune response is the first line of defence strategies in invertebrates against attack of infectious agents. A detailed analysis of the immune mechanisms involved in annelids has been performed in oligochaets, but few data are... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10103482" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The innate immune response is the first line of defence strategies in invertebrates against attack of infectious agents. A detailed analysis of the immune mechanisms involved in annelids has been performed in oligochaets, but few data are available in polichaets and hirudineans.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10103482" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="62109b9c274911d6933eb9eb52695962" rel="nofollow" data-download="{"attachment_id":47530406,"asset_id":10103482,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47530406/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="24629533" href="https://independent.academia.edu/GianlucaTettamanti">Gianluca Tettamanti</a><script data-card-contents-for-user="24629533" type="text/json">{"id":24629533,"first_name":"Gianluca","last_name":"Tettamanti","domain_name":"independent","page_name":"GianlucaTettamanti","display_name":"Gianluca Tettamanti","profile_url":"https://independent.academia.edu/GianlucaTettamanti?f_ri=893785","photo":"https://0.academia-photos.com/24629533/6660068/7525670/s65_gianluca.tettamanti.jpg_oh_d15264c803d428cfd7e037121bc45431_oe_55316205___gda___1429635226_6b37231fdc0720d85e56d05095c46998"}</script></span></span></li><li class="js-paper-rank-work_10103482 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10103482"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10103482, container: ".js-paper-rank-work_10103482", }); 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A detailed analysis of the immune mechanisms involved in annelids has been performed in oligochaets, but few data are available in polichaets and hirudineans.","downloadable_attachments":[{"id":47530406,"asset_id":10103482,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":24629533,"first_name":"Gianluca","last_name":"Tettamanti","domain_name":"independent","page_name":"GianlucaTettamanti","display_name":"Gianluca Tettamanti","profile_url":"https://independent.academia.edu/GianlucaTettamanti?f_ri=893785","photo":"https://0.academia-photos.com/24629533/6660068/7525670/s65_gianluca.tettamanti.jpg_oh_d15264c803d428cfd7e037121bc45431_oe_55316205___gda___1429635226_6b37231fdc0720d85e56d05095c46998"}],"research_interests":[{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response?f_ri=893785","nofollow":true},{"id":8991,"name":"Wound Healing","url":"https://www.academia.edu/Documents/in/Wound_Healing?f_ri=893785","nofollow":true},{"id":281437,"name":"Leeches","url":"https://www.academia.edu/Documents/in/Leeches?f_ri=893785","nofollow":true},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785","nofollow":true},{"id":1267724,"name":"Biomedical Application","url":"https://www.academia.edu/Documents/in/Biomedical_Application?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27254870" data-work_id="27254870" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27254870/Infections_and_solid_organ_transplant_rejection_a_cause_and_effect_relationship">Infections and solid organ transplant rejection: a cause-and-effect relationship?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Although evidence is far from being conclusive, several studies have suggested that infections could trigger rejection in different transplant settings. In this review we examine the evidence linking cytomegalovirus (CMV), adenovirus,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27254870" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Although evidence is far from being conclusive, several studies have suggested that infections could trigger rejection in different transplant settings. In this review we examine the evidence linking cytomegalovirus (CMV), adenovirus, enterovirus, parvovirus, and herpes simplex virus infections to the vasculopathy leading to cardiac allograft rejection, the association between CMV and chronic kidney, lung, and liver graft rejection, and the association of human herpesvirus 6 reactivation with CMV-related disease in kidney and liver transplant recipients. We also review the numerous antiviral prophylactic or pre-emptive treatments in use to control CMV infection, and suggest that they do not limit immune reactions leading to graft rejection or lower the risk of developing post-transplantation atherosclerosis in allograft recipients. Finally, we emphasise the need for prospective, international studies to clarify the role of infections in transplant rejection, to look at virus-to-virus interactions, and to establish specific therapeutic strategies. Such strategies must not rely exclusively on expensive antiviral agents but also on vaccination or other, innovative approaches, such as the use of agents able to inhibit the activity of natural killer cells, which might have an important role in acute allograft rejection.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27254870" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d8da11ad0678fef5a553365f3324154d" rel="nofollow" data-download="{"attachment_id":47514993,"asset_id":27254870,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47514993/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="51298509" href="https://puthisastra.academia.edu/SandroVento">Sandro Vento</a><script data-card-contents-for-user="51298509" type="text/json">{"id":51298509,"first_name":"Sandro","last_name":"Vento","domain_name":"puthisastra","page_name":"SandroVento","display_name":"Sandro Vento","profile_url":"https://puthisastra.academia.edu/SandroVento?f_ri=893785","photo":"https://0.academia-photos.com/51298509/13590309/144526959/s65_sandro.vento.jpg"}</script></span></span></li><li class="js-paper-rank-work_27254870 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27254870"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27254870, container: ".js-paper-rank-work_27254870", }); 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$(".js-view-count[data-work-id=27254870]").text(description); $(".js-view-count-work_27254870").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27254870").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27254870"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6947" rel="nofollow" href="https://www.academia.edu/Documents/in/Medical_Microbiology">Medical Microbiology</a>, <script data-card-contents-for-ri="6947" type="text/json">{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9003" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_transplantation">Kidney transplantation</a>, <script data-card-contents-for-ri="9003" type="text/json">{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" rel="nofollow" href="https://www.academia.edu/Documents/in/Child">Child</a>, <script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="108409" rel="nofollow" href="https://www.academia.edu/Documents/in/Organ_Transplantation">Organ Transplantation</a><script data-card-contents-for-ri="108409" type="text/json">{"id":108409,"name":"Organ Transplantation","url":"https://www.academia.edu/Documents/in/Organ_Transplantation?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27254870]'), work: {"id":27254870,"title":"Infections and solid organ transplant rejection: a cause-and-effect relationship?","created_at":"2016-07-25T18:23:08.230-07:00","url":"https://www.academia.edu/27254870/Infections_and_solid_organ_transplant_rejection_a_cause_and_effect_relationship?f_ri=893785","dom_id":"work_27254870","summary":"Although evidence is far from being conclusive, several studies have suggested that infections could trigger rejection in different transplant settings. In this review we examine the evidence linking cytomegalovirus (CMV), adenovirus, enterovirus, parvovirus, and herpes simplex virus infections to the vasculopathy leading to cardiac allograft rejection, the association between CMV and chronic kidney, lung, and liver graft rejection, and the association of human herpesvirus 6 reactivation with CMV-related disease in kidney and liver transplant recipients. We also review the numerous antiviral prophylactic or pre-emptive treatments in use to control CMV infection, and suggest that they do not limit immune reactions leading to graft rejection or lower the risk of developing post-transplantation atherosclerosis in allograft recipients. Finally, we emphasise the need for prospective, international studies to clarify the role of infections in transplant rejection, to look at virus-to-virus interactions, and to establish specific therapeutic strategies. Such strategies must not rely exclusively on expensive antiviral agents but also on vaccination or other, innovative approaches, such as the use of agents able to inhibit the activity of natural killer cells, which might have an important role in acute allograft rejection.","downloadable_attachments":[{"id":47514993,"asset_id":27254870,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":51298509,"first_name":"Sandro","last_name":"Vento","domain_name":"puthisastra","page_name":"SandroVento","display_name":"Sandro Vento","profile_url":"https://puthisastra.academia.edu/SandroVento?f_ri=893785","photo":"https://0.academia-photos.com/51298509/13590309/144526959/s65_sandro.vento.jpg"}],"research_interests":[{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=893785","nofollow":true},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=893785","nofollow":true},{"id":108409,"name":"Organ Transplantation","url":"https://www.academia.edu/Documents/in/Organ_Transplantation?f_ri=893785","nofollow":true},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation?f_ri=893785"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785"},{"id":699649,"name":"Cytomegalovirus Infections","url":"https://www.academia.edu/Documents/in/Cytomegalovirus_Infections?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1036494,"name":"Heart and Lung Transplantation","url":"https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation?f_ri=893785"},{"id":1622318,"name":"Antiviral Agents","url":"https://www.academia.edu/Documents/in/Antiviral_Agents?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_12787974" data-work_id="12787974" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12787974/Long_term_effects_of_single_versus_double_CsA_dosing_in_kidney_transplantation">Long-term effects of single versus double CsA dosing in kidney transplantation</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button 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workId = 12787974; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12787974]").text(description); $(".js-view-count-work_12787974").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_12787974").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="12787974"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9003" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_transplantation">Kidney transplantation</a>, <script data-card-contents-for-ri="9003" type="text/json">{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="24856" rel="nofollow" href="https://www.academia.edu/Documents/in/STEROIDS">STEROIDS</a>, <script data-card-contents-for-ri="24856" type="text/json">{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="33069" rel="nofollow" href="https://www.academia.edu/Documents/in/Probability">Probability</a>, <script data-card-contents-for-ri="33069" type="text/json">{"id":33069,"name":"Probability","url":"https://www.academia.edu/Documents/in/Probability?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="41482" rel="nofollow" href="https://www.academia.edu/Documents/in/Multivariate_Analysis">Multivariate Analysis</a><script data-card-contents-for-ri="41482" type="text/json">{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=12787974]'), work: {"id":12787974,"title":"Long-term effects of single versus double CsA dosing in kidney transplantation","created_at":"2015-06-03T23:59:59.733-07:00","url":"https://www.academia.edu/12787974/Long_term_effects_of_single_versus_double_CsA_dosing_in_kidney_transplantation?f_ri=893785","dom_id":"work_12787974","summary":null,"downloadable_attachments":[{"id":45933409,"asset_id":12787974,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":31856762,"first_name":"Claudio","last_name":"Ponticelli","domain_name":"independent","page_name":"ClaudioPonticelli","display_name":"Claudio Ponticelli","profile_url":"https://independent.academia.edu/ClaudioPonticelli?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true},{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS?f_ri=893785","nofollow":true},{"id":33069,"name":"Probability","url":"https://www.academia.edu/Documents/in/Probability?f_ri=893785","nofollow":true},{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=893785","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=893785"},{"id":168352,"name":"Cyclosporine","url":"https://www.academia.edu/Documents/in/Cyclosporine?f_ri=893785"},{"id":379033,"name":"Kidney Transplant","url":"https://www.academia.edu/Documents/in/Kidney_Transplant?f_ri=893785"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=893785"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=893785"},{"id":800515,"name":"Long Term Effect","url":"https://www.academia.edu/Documents/in/Long_Term_Effect?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":2463621,"name":"Postoperative Complications","url":"https://www.academia.edu/Documents/in/Postoperative_Complications?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24727046" data-work_id="24727046" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24727046/Incidence_Risk_Factors_and_Clinical_Consequences_of_Neutropenia_Following_Kidney_Transplantation_A_Retrospective_Study">Incidence, Risk Factors and Clinical Consequences of Neutropenia Following Kidney Transplantation: A Retrospective Study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Neutropenic episodes in kidney transplant patients are poorly characterized. In this retrospective study, neutropenia was experienced by 112/395 patients (28%) during the first year posttransplant. The only factor found to be... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24727046" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Neutropenic episodes in kidney transplant patients are poorly characterized. In this retrospective study, neutropenia was experienced by 112/395 patients (28%) during the first year posttransplant. The only factor found to be significantly associated with the occurrence of neutropenia was combined tacrolimusmycophenolate therapy (p < 0.001). Neutropenic patients experienced more bacterial infections (43% vs. 32%, p = 0.04). Grade of neutropenia correlated with the global risk of infection. Discontinuation of mycophenolic acid (MPA) due to neutropenia was associated with an increased incidence of acute rejection (odds ratios per day 1.11, 95% confidence intervals 1.02-1.22) but not with reduced renal function at 1 year. The time from onset of neutropenia to MPA discontinuation correlated with the duration of neutropenia. Granulocyte colony-stimulating factor (G-CSF) administration was safe and effective in severely neutropenic kidney graft recipients, with absolute neutrophil count >1000/lL achieved in a mean of 1.5 ± 0.5 days. Neutropenia is an important and frequent laboratory finding that may exert a significant influence on outcomes in kidney transplantation. As well as leading to an increased incidence of infection, it is associated with a higher rate of allograft rejection if MPA is discontinued for >6 days (p = 0.02). G-CSF accelerates recovery of neutropenia and may be a good therapeutic alternative for severely neutropenic patients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24727046" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2e074e6614970c9c5ffa35fd6f94edfc" rel="nofollow" data-download="{"attachment_id":45057643,"asset_id":24727046,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45057643/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="47671530" href="https://independent.academia.edu/MagaliCiroldi">Magali Ciroldi</a><script data-card-contents-for-user="47671530" type="text/json">{"id":47671530,"first_name":"Magali","last_name":"Ciroldi","domain_name":"independent","page_name":"MagaliCiroldi","display_name":"Magali Ciroldi","profile_url":"https://independent.academia.edu/MagaliCiroldi?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24727046 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24727046"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24727046, container: ".js-paper-rank-work_24727046", }); });</script></li><li class="js-percentile-work_24727046 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24727046; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24727046"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24727046 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24727046"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24727046; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24727046]").text(description); $(".js-view-count-work_24727046").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24727046").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24727046"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9003" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_transplantation">Kidney transplantation</a>, <script data-card-contents-for-ri="9003" type="text/json">{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="57818" rel="nofollow" href="https://www.academia.edu/Documents/in/Tacrolimus">Tacrolimus</a>, <script data-card-contents-for-ri="57818" type="text/json">{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="174502" rel="nofollow" href="https://www.academia.edu/Documents/in/Incidence">Incidence</a>, <script data-card-contents-for-ri="174502" type="text/json">{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="192721" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk_factors">Risk factors</a><script data-card-contents-for-ri="192721" type="text/json">{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24727046]'), work: {"id":24727046,"title":"Incidence, Risk Factors and Clinical Consequences of Neutropenia Following Kidney Transplantation: A Retrospective Study","created_at":"2016-04-24T23:39:51.035-07:00","url":"https://www.academia.edu/24727046/Incidence_Risk_Factors_and_Clinical_Consequences_of_Neutropenia_Following_Kidney_Transplantation_A_Retrospective_Study?f_ri=893785","dom_id":"work_24727046","summary":"Neutropenic episodes in kidney transplant patients are poorly characterized. In this retrospective study, neutropenia was experienced by 112/395 patients (28%) during the first year posttransplant. The only factor found to be significantly associated with the occurrence of neutropenia was combined tacrolimusmycophenolate therapy (p \u003c 0.001). Neutropenic patients experienced more bacterial infections (43% vs. 32%, p = 0.04). Grade of neutropenia correlated with the global risk of infection. Discontinuation of mycophenolic acid (MPA) due to neutropenia was associated with an increased incidence of acute rejection (odds ratios per day 1.11, 95% confidence intervals 1.02-1.22) but not with reduced renal function at 1 year. The time from onset of neutropenia to MPA discontinuation correlated with the duration of neutropenia. Granulocyte colony-stimulating factor (G-CSF) administration was safe and effective in severely neutropenic kidney graft recipients, with absolute neutrophil count \u003e1000/lL achieved in a mean of 1.5 ± 0.5 days. Neutropenia is an important and frequent laboratory finding that may exert a significant influence on outcomes in kidney transplantation. As well as leading to an increased incidence of infection, it is associated with a higher rate of allograft rejection if MPA is discontinued for \u003e6 days (p = 0.02). G-CSF accelerates recovery of neutropenia and may be a good therapeutic alternative for severely neutropenic patients.","downloadable_attachments":[{"id":45057643,"asset_id":24727046,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":47671530,"first_name":"Magali","last_name":"Ciroldi","domain_name":"independent","page_name":"MagaliCiroldi","display_name":"Magali Ciroldi","profile_url":"https://independent.academia.edu/MagaliCiroldi?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus?f_ri=893785","nofollow":true},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=893785","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=893785","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=893785"},{"id":379033,"name":"Kidney Transplant","url":"https://www.academia.edu/Documents/in/Kidney_Transplant?f_ri=893785"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy?f_ri=893785"},{"id":587528,"name":"Bacterial infections","url":"https://www.academia.edu/Documents/in/Bacterial_infections?f_ri=893785"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":990198,"name":"Retrospective Study","url":"https://www.academia.edu/Documents/in/Retrospective_Study?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22258054" data-work_id="22258054" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22258054/Surveillance_and_Rescue_of_Pancreas_Grafts">Surveillance and Rescue of Pancreas Grafts</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background. Technical failure rates are higher for pancreas allografts (PA) compared with other solid organs. Posttransplant surveillance and prompt availability of rescue teams with multidisciplinary expertise both contribute to improve... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22258054" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background. Technical failure rates are higher for pancreas allografts (PA) compared with other solid organs. Posttransplant surveillance and prompt availability of rescue teams with multidisciplinary expertise both contribute to improve this result. We herein report a single institution's experience with posttransplant surveillance and rescue of PA. Methods. A retrospective survey was performed of a consecutive series of 177 whole organ pancreas transplants in 173 patients. Antithrombotic prophylaxis was used in all recipients and tailored on anticipated individual risk of thrombosis. During the first posttransplant week, all PA were monitored with daily Doppler ultrasonography. Surgical complications were defined as all adverse events requiring relaparotomy during the initial hospital stay or the first 3 posttransplant months. Results. A total of 26 relaparotomies were performed in 25 patients (14.7%). One recipient needed two relaparotomies (0.6%). Graft rescue was attempted in patients without permanent parenchymal damage at repeat surgery and in 12 recipients diagnosed with nonocclusive vascular thrombosis. Overall 25 grafts (96.3%) were rescued and one was lost. One-year recipient and graft survivals in patients with versus without complications potentially leading to allograft loss were 92.6% and 63.0% versus 94.4% and 94.3%, respectively. Excluding complications for which graft rescue was not possible, 1-year graft survival rate increased to 78.7%. Conclusions. Close posttransplant surveillance can allow rescue of a relevant proportion of PA developing nonocclusive venous thrombosis or other surgical complications. Further improvement awaits better understanding of biological reasons for posttransplant complications jeopardizing PA survival and the development of more effective preventive measures.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22258054" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8f859e58971881f4c4b3d07dd0db509a" rel="nofollow" data-download="{"attachment_id":42907889,"asset_id":22258054,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42907889/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43639132" href="https://pisa.academia.edu/LucaMorelli">Luca Morelli</a><script data-card-contents-for-user="43639132" type="text/json">{"id":43639132,"first_name":"Luca","last_name":"Morelli","domain_name":"pisa","page_name":"LucaMorelli","display_name":"Luca Morelli","profile_url":"https://pisa.academia.edu/LucaMorelli?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22258054 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22258054"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22258054, container: ".js-paper-rank-work_22258054", }); });</script></li><li class="js-percentile-work_22258054 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22258054; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_22258054"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_22258054 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="22258054"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22258054; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22258054]").text(description); $(".js-view-count-work_22258054").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_22258054").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="22258054"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="10610" rel="nofollow" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="51530" rel="nofollow" href="https://www.academia.edu/Documents/in/Transplantation">Transplantation</a>, <script data-card-contents-for-ri="51530" type="text/json">{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="118540" rel="nofollow" href="https://www.academia.edu/Documents/in/Immunosuppression">Immunosuppression</a>, <script data-card-contents-for-ri="118540" type="text/json">{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="395473" rel="nofollow" href="https://www.academia.edu/Documents/in/Patient_Care_Team">Patient Care Team</a><script data-card-contents-for-ri="395473" type="text/json">{"id":395473,"name":"Patient Care Team","url":"https://www.academia.edu/Documents/in/Patient_Care_Team?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22258054]'), work: {"id":22258054,"title":"Surveillance and Rescue of Pancreas Grafts","created_at":"2016-02-21T10:49:01.450-08:00","url":"https://www.academia.edu/22258054/Surveillance_and_Rescue_of_Pancreas_Grafts?f_ri=893785","dom_id":"work_22258054","summary":"Background. Technical failure rates are higher for pancreas allografts (PA) compared with other solid organs. Posttransplant surveillance and prompt availability of rescue teams with multidisciplinary expertise both contribute to improve this result. We herein report a single institution's experience with posttransplant surveillance and rescue of PA. Methods. A retrospective survey was performed of a consecutive series of 177 whole organ pancreas transplants in 173 patients. Antithrombotic prophylaxis was used in all recipients and tailored on anticipated individual risk of thrombosis. During the first posttransplant week, all PA were monitored with daily Doppler ultrasonography. Surgical complications were defined as all adverse events requiring relaparotomy during the initial hospital stay or the first 3 posttransplant months. Results. A total of 26 relaparotomies were performed in 25 patients (14.7%). One recipient needed two relaparotomies (0.6%). Graft rescue was attempted in patients without permanent parenchymal damage at repeat surgery and in 12 recipients diagnosed with nonocclusive vascular thrombosis. Overall 25 grafts (96.3%) were rescued and one was lost. One-year recipient and graft survivals in patients with versus without complications potentially leading to allograft loss were 92.6% and 63.0% versus 94.4% and 94.3%, respectively. Excluding complications for which graft rescue was not possible, 1-year graft survival rate increased to 78.7%. Conclusions. Close posttransplant surveillance can allow rescue of a relevant proportion of PA developing nonocclusive venous thrombosis or other surgical complications. Further improvement awaits better understanding of biological reasons for posttransplant complications jeopardizing PA survival and the development of more effective preventive measures.","downloadable_attachments":[{"id":42907889,"asset_id":22258054,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43639132,"first_name":"Luca","last_name":"Morelli","domain_name":"pisa","page_name":"LucaMorelli","display_name":"Luca Morelli","profile_url":"https://pisa.academia.edu/LucaMorelli?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=893785","nofollow":true},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation?f_ri=893785","nofollow":true},{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression?f_ri=893785","nofollow":true},{"id":395473,"name":"Patient Care Team","url":"https://www.academia.edu/Documents/in/Patient_Care_Team?f_ri=893785","nofollow":true},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1178952,"name":"Pancreas Transplantation","url":"https://www.academia.edu/Documents/in/Pancreas_Transplantation?f_ri=893785"},{"id":1953423,"name":"Postoperative Period","url":"https://www.academia.edu/Documents/in/Postoperative_Period?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20395221 coauthored" data-work_id="20395221" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20395221/MHC_class_I_restricted_epitope_spreading_in_the_context_of_tumor_rejection_following_vaccination_with_a_single_immunodominant_CTL_epitope">MHC class I-restricted epitope spreading in the context of tumor rejection following vaccination with a single immunodominant CTL epitope</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Epitope spreading is a process whereby epitopes distinct from and non-cross-reactive with an inducing epitope become targets of an evolving immune response. This phenomenon has been associated most notably with the progression of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20395221" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Epitope spreading is a process whereby epitopes distinct from and non-cross-reactive with an inducing epitope become targets of an evolving immune response. This phenomenon has been associated most notably with the progression of naturally occurring or experimentally induced chronic autoimmune diseases. We have investigated the potential occurrence of epitope spreading in the context of antitumor cytotoxic T cell (CTL) responses using chicken ovalbumin (OVA) as a model antigen. Our results indicate that following rejection of OVAexpressing EG.7 tumor cells effectuated by a CTL response which is induced against the MHC class I-restricted immunodominant epitope OVA257-264, there occurs intramolecular diversification of the CTL response to two additional OVA-derived epitopes, OVA176-183 and OVA55-62, as well as intermolecular spreading to other endogenous tumor-derived determinants. It seems that CTL-mediated tumor cell destruction in vivo favors crosspresentation of additional epitopes with the consequent activation of additional tumorreactive lymphocytes. The process of epitope spreading in that context has obvious important implications for the design of antigen-specific antitumor immunotherapies.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20395221" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8dfb180512787ae52ffa03acb3d9a837" rel="nofollow" data-download="{"attachment_id":41338327,"asset_id":20395221,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41338327/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41770368" href="https://independent.academia.edu/LiorCarmon">Lior Carmon</a><script data-card-contents-for-user="41770368" type="text/json">{"id":41770368,"first_name":"Lior","last_name":"Carmon","domain_name":"independent","page_name":"LiorCarmon","display_name":"Lior Carmon","profile_url":"https://independent.academia.edu/LiorCarmon?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-20395221">+1</span><div class="hidden js-additional-users-20395221"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/KElShami">Khaled El-Shami</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-20395221'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-20395221').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_20395221 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20395221"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20395221, container: ".js-paper-rank-work_20395221", }); });</script></li><li class="js-percentile-work_20395221 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20395221; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_20395221"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_20395221 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="20395221"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20395221; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20395221]").text(description); $(".js-view-count-work_20395221").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20395221").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20395221"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1290" rel="nofollow" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43106" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer_Vaccines">Cancer Vaccines</a>, <script data-card-contents-for-ri="43106" type="text/json">{"id":43106,"name":"Cancer Vaccines","url":"https://www.academia.edu/Documents/in/Cancer_Vaccines?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="84760" rel="nofollow" href="https://www.academia.edu/Documents/in/Mice">Mice</a>, <script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a><script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20395221]'), work: {"id":20395221,"title":"MHC class I-restricted epitope spreading in the context of tumor rejection following vaccination with a single immunodominant CTL epitope","created_at":"2016-01-19T18:45:44.307-08:00","url":"https://www.academia.edu/20395221/MHC_class_I_restricted_epitope_spreading_in_the_context_of_tumor_rejection_following_vaccination_with_a_single_immunodominant_CTL_epitope?f_ri=893785","dom_id":"work_20395221","summary":"Epitope spreading is a process whereby epitopes distinct from and non-cross-reactive with an inducing epitope become targets of an evolving immune response. This phenomenon has been associated most notably with the progression of naturally occurring or experimentally induced chronic autoimmune diseases. We have investigated the potential occurrence of epitope spreading in the context of antitumor cytotoxic T cell (CTL) responses using chicken ovalbumin (OVA) as a model antigen. Our results indicate that following rejection of OVAexpressing EG.7 tumor cells effectuated by a CTL response which is induced against the MHC class I-restricted immunodominant epitope OVA257-264, there occurs intramolecular diversification of the CTL response to two additional OVA-derived epitopes, OVA176-183 and OVA55-62, as well as intermolecular spreading to other endogenous tumor-derived determinants. It seems that CTL-mediated tumor cell destruction in vivo favors crosspresentation of additional epitopes with the consequent activation of additional tumorreactive lymphocytes. The process of epitope spreading in that context has obvious important implications for the design of antigen-specific antitumor immunotherapies.","downloadable_attachments":[{"id":41338327,"asset_id":20395221,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":41770368,"first_name":"Lior","last_name":"Carmon","domain_name":"independent","page_name":"LiorCarmon","display_name":"Lior Carmon","profile_url":"https://independent.academia.edu/LiorCarmon?f_ri=893785","photo":"/images/s65_no_pic.png"},{"id":42274316,"first_name":"Khaled","last_name":"El-Shami","domain_name":"independent","page_name":"KElShami","display_name":"Khaled El-Shami","profile_url":"https://independent.academia.edu/KElShami?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=893785","nofollow":true},{"id":43106,"name":"Cancer Vaccines","url":"https://www.academia.edu/Documents/in/Cancer_Vaccines?f_ri=893785","nofollow":true},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=893785","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=893785","nofollow":true},{"id":402759,"name":"Chickens","url":"https://www.academia.edu/Documents/in/Chickens?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1330386,"name":"MHC class I","url":"https://www.academia.edu/Documents/in/MHC_class_I?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_78191362" data-work_id="78191362" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/78191362/Immune_Complex_Formation_after_Xenotransplantation">Immune Complex Formation after Xenotransplantation</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/78191362" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dcbcf3acef5236e92290962e62fc8fed" rel="nofollow" data-download="{"attachment_id":85324703,"asset_id":78191362,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen 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Bustos","profile_url":"https://independent.academia.edu/MatildeBustos4?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_78191362 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="78191362"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 78191362, container: ".js-paper-rank-work_78191362", }); });</script></li><li class="js-percentile-work_78191362 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78191362; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_78191362"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_78191362 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="78191362"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78191362; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78191362]").text(description); $(".js-view-count-work_78191362").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_78191362").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="78191362"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" rel="nofollow" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7710" rel="nofollow" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9003" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_transplantation">Kidney transplantation</a>, <script data-card-contents-for-ri="9003" type="text/json">{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=78191362]'), work: {"id":78191362,"title":"Immune Complex Formation after Xenotransplantation","created_at":"2022-05-02T00:56:10.381-07:00","url":"https://www.academia.edu/78191362/Immune_Complex_Formation_after_Xenotransplantation?f_ri=893785","dom_id":"work_78191362","summary":null,"downloadable_attachments":[{"id":85324703,"asset_id":78191362,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":162935831,"first_name":"Matilde","last_name":"Bustos","domain_name":"independent","page_name":"MatildeBustos4","display_name":"Matilde Bustos","profile_url":"https://independent.academia.edu/MatildeBustos4?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=893785","nofollow":true},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=893785","nofollow":true},{"id":9003,"name":"Kidney 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u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_74168704" data-work_id="74168704" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/74168704/The_role_of_innate_immunity_in_acute_allograft_rejection_after_lung_transplantation">The role of innate immunity in acute allograft rejection after lung transplantation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Although innate immunity is crucial to pulmonary host defense and can initiate immune and inflammatory responses independent of adaptive immunity, it remains unstudied in the context of transplant rejection. To investigate the role of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_74168704" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Although innate immunity is crucial to pulmonary host defense and can initiate immune and inflammatory responses independent of adaptive immunity, it remains unstudied in the context of transplant rejection. To investigate the role of innate immunity in the development of allograft ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/74168704" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="622bd380a3b21b88506472c2be127d52" rel="nofollow" data-download="{"attachment_id":82414529,"asset_id":74168704,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82414529/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="212561698" href="https://independent.academia.edu/DavidHowell47">David Howell</a><script data-card-contents-for-user="212561698" type="text/json">{"id":212561698,"first_name":"David","last_name":"Howell","domain_name":"independent","page_name":"DavidHowell47","display_name":"David Howell","profile_url":"https://independent.academia.edu/DavidHowell47?f_ri=893785","photo":"https://0.academia-photos.com/212561698/71646862/60095835/s65_david.howell.png"}</script></span></span></li><li class="js-paper-rank-work_74168704 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="74168704"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 74168704, container: ".js-paper-rank-work_74168704", }); 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To investigate the role of innate immunity in the development of allograft ...","downloadable_attachments":[{"id":82414529,"asset_id":74168704,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":212561698,"first_name":"David","last_name":"Howell","domain_name":"independent","page_name":"DavidHowell47","display_name":"David Howell","profile_url":"https://independent.academia.edu/DavidHowell47?f_ri=893785","photo":"https://0.academia-photos.com/212561698/71646862/60095835/s65_david.howell.png"}],"research_interests":[{"id":24706,"name":"Innate immunity","url":"https://www.academia.edu/Documents/in/Innate_immunity?f_ri=893785","nofollow":true},{"id":48181,"name":"Inflammatory Immune Response","url":"https://www.academia.edu/Documents/in/Inflammatory_Immune_Response?f_ri=893785","nofollow":true},{"id":88770,"name":"Adaptive Immunity","url":"https://www.academia.edu/Documents/in/Adaptive_Immunity?f_ri=893785","nofollow":true},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American?f_ri=893785","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=893785"},{"id":809882,"name":"Base Sequence","url":"https://www.academia.edu/Documents/in/Base_Sequence?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":968937,"name":"Logistic Regression Model","url":"https://www.academia.edu/Documents/in/Logistic_Regression_Model?f_ri=893785"},{"id":1036494,"name":"Heart and Lung Transplantation","url":"https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation?f_ri=893785"},{"id":1740532,"name":"Acute rejection","url":"https://www.academia.edu/Documents/in/Acute_rejection?f_ri=893785"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=893785"},{"id":2192856,"name":"Host Defense","url":"https://www.academia.edu/Documents/in/Host_Defense?f_ri=893785"},{"id":2454817,"name":"Inflammatory response","url":"https://www.academia.edu/Documents/in/Inflammatory_response?f_ri=893785"},{"id":2471455,"name":"Acute Disease","url":"https://www.academia.edu/Documents/in/Acute_Disease?f_ri=893785"},{"id":2731176,"name":"Lung Transplantation","url":"https://www.academia.edu/Documents/in/Lung_Transplantation?f_ri=893785"},{"id":2780137,"name":"alleles","url":"https://www.academia.edu/Documents/in/alleles?f_ri=893785"},{"id":3026219,"name":"innate immune response","url":"https://www.academia.edu/Documents/in/innate_immune_response?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14043572" data-work_id="14043572" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14043572/Preemptive_Living_Donor_Renal_Transplantation_A_Single_Center_Experience">Preemptive Living Donor Renal Transplantation: A Single-Center Experience</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Introduction. Kidney transplant recipients have a higher quality of life and consume fewer health care resources compared with patients on dialysis. However, optimal timing of transplantation has been controversial. Recent studies have... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14043572" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Introduction. Kidney transplant recipients have a higher quality of life and consume fewer health care resources compared with patients on dialysis. However, optimal timing of transplantation has been controversial. Recent studies have clearly demonstrated that preemptive renal transplantation is associated with better graft survival, lower complications, and better cost-effective outcomes. We evaluated differential effects on long-term outcomes according to dialysis type/duration versus no dialysis. Materials and Methods. We retrospectively analyzed 499 cases of first living-donor kidney transplantations performed in our center from January 1990 to January 2007. We compared 3 groups according to graft survival, acute and chronic rejection, postoperative complication, and delayed graft function rates. The mean duration of follow-up was 119.1 Ϯ 47.2 months. Results. Among 499 cases, 81 cases were preemptive renal transplantations with 418 cases hemodialysis [HD], 343 cases, peritoneal dialysis [PD] 75 cases) performed after dialysis. The 1-, 5-, and 10-year graft survival rates were 98.8%, 89.5%, 79.4% among the preemptive renal transplantation group and 92.4%, 78.2%, and 69.2% and 85.3%, 74.5%, and 68.2% (P ϭ .03) in the dialysis groups (HD, PD), respectively. The differential effect of pretransplantation HD or PD was not significant. However, the graft survival rates in the HD group were not significantly higher than the PD group (P ϭ .61). The duration of dialysis was not associated with graft survival. Conclusion. We suggest that preemptive renal transplantation should be the first choice of treatment for patients with end-stage renal disease.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14043572" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="84577c221995e6fc9ea489c297f0fcf7" rel="nofollow" data-download="{"attachment_id":44670717,"asset_id":14043572,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44670717/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33066403" href="https://independent.academia.edu/EsraBaskin">Esra Baskin</a><script data-card-contents-for-user="33066403" type="text/json">{"id":33066403,"first_name":"Esra","last_name":"Baskin","domain_name":"independent","page_name":"EsraBaskin","display_name":"Esra Baskin","profile_url":"https://independent.academia.edu/EsraBaskin?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14043572 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14043572"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14043572, container: ".js-paper-rank-work_14043572", }); 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Kidney transplant recipients have a higher quality of life and consume fewer health care resources compared with patients on dialysis. However, optimal timing of transplantation has been controversial. Recent studies have clearly demonstrated that preemptive renal transplantation is associated with better graft survival, lower complications, and better cost-effective outcomes. We evaluated differential effects on long-term outcomes according to dialysis type/duration versus no dialysis. Materials and Methods. We retrospectively analyzed 499 cases of first living-donor kidney transplantations performed in our center from January 1990 to January 2007. We compared 3 groups according to graft survival, acute and chronic rejection, postoperative complication, and delayed graft function rates. The mean duration of follow-up was 119.1 Ϯ 47.2 months. Results. Among 499 cases, 81 cases were preemptive renal transplantations with 418 cases hemodialysis [HD], 343 cases, peritoneal dialysis [PD] 75 cases) performed after dialysis. The 1-, 5-, and 10-year graft survival rates were 98.8%, 89.5%, 79.4% among the preemptive renal transplantation group and 92.4%, 78.2%, and 69.2% and 85.3%, 74.5%, and 68.2% (P ϭ .03) in the dialysis groups (HD, PD), respectively. The differential effect of pretransplantation HD or PD was not significant. However, the graft survival rates in the HD group were not significantly higher than the PD group (P ϭ .61). The duration of dialysis was not associated with graft survival. Conclusion. We suggest that preemptive renal transplantation should be the first choice of treatment for patients with end-stage renal disease.","downloadable_attachments":[{"id":44670717,"asset_id":14043572,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33066403,"first_name":"Esra","last_name":"Baskin","domain_name":"independent","page_name":"EsraBaskin","display_name":"Esra Baskin","profile_url":"https://independent.academia.edu/EsraBaskin?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4441,"name":"Health Care","url":"https://www.academia.edu/Documents/in/Health_Care?f_ri=893785","nofollow":true},{"id":6574,"name":"Family","url":"https://www.academia.edu/Documents/in/Family?f_ri=893785","nofollow":true},{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=893785","nofollow":true},{"id":8999,"name":"Kidney diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases?f_ri=893785","nofollow":true},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=893785"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation?f_ri=893785"},{"id":58379,"name":"Renal transplantation","url":"https://www.academia.edu/Documents/in/Renal_transplantation?f_ri=893785"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=893785"},{"id":82641,"name":"Survivors","url":"https://www.academia.edu/Documents/in/Survivors?f_ri=893785"},{"id":85188,"name":"End Stage Renal Disease","url":"https://www.academia.edu/Documents/in/End_Stage_Renal_Disease?f_ri=893785"},{"id":108407,"name":"End Stage Renal Failure","url":"https://www.academia.edu/Documents/in/End_Stage_Renal_Failure?f_ri=893785"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=893785"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=893785"},{"id":227311,"name":"Serum Creatinine","url":"https://www.academia.edu/Documents/in/Serum_Creatinine?f_ri=893785"},{"id":227354,"name":"Renal Function","url":"https://www.academia.edu/Documents/in/Renal_Function?f_ri=893785"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=893785"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=893785"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=893785"},{"id":447741,"name":"Peritoneal Dialysis","url":"https://www.academia.edu/Documents/in/Peritoneal_Dialysis?f_ri=893785"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure?f_ri=893785"},{"id":1180098,"name":"Renal disease","url":"https://www.academia.edu/Documents/in/Renal_disease?f_ri=893785"},{"id":1343221,"name":"Renal Replacement Therapy","url":"https://www.academia.edu/Documents/in/Renal_Replacement_Therapy?f_ri=893785"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine?f_ri=893785"},{"id":1611680,"name":"Renal Dialysis","url":"https://www.academia.edu/Documents/in/Renal_Dialysis?f_ri=893785"},{"id":2249441,"name":"Focal Segmental Glomerulosclerosis","url":"https://www.academia.edu/Documents/in/Focal_Segmental_Glomerulosclerosis?f_ri=893785"},{"id":2366663,"name":"Glomerular Filtration Rate","url":"https://www.academia.edu/Documents/in/Glomerular_Filtration_Rate?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_51092746" data-work_id="51092746" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/51092746/Magnetocardiography_current_status_and_perspectives_Part_II_Clinical_applications">Magnetocardiography: current status and perspectives. Part II: Clinical applications</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Magnetocardiography (MCG) is a non-invasive and risk-free technique allowing body surface recording of the magnetic fields generated by the electrical activity of the heart. The MCG recording system allows spatially and temporally... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_51092746" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Magnetocardiography (MCG) is a non-invasive and risk-free technique allowing body surface recording of the magnetic fields generated by the electrical activity of the heart. The MCG recording system allows spatially and temporally accurate measurements of the very weak magnetic fields produced by currents flowing within myocardial fibers during cardiac activity. MCG has now been around for over 30 years, but only recently has progress in instrumentation put the technique on the verge of clinical applicability. This review summarizes the physical principles, instrumentation, main clinical applications and perspectives for the clinical use of MCG. This first part is devoted to the description of the physical principles and instrumentation.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/51092746" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8577fd4e8d398b8a432be30268f70cae" rel="nofollow" data-download="{"attachment_id":68943928,"asset_id":51092746,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/68943928/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="201874371" href="https://unich-it.academia.edu/SilviaComani">Silvia Comani</a><script data-card-contents-for-user="201874371" type="text/json">{"id":201874371,"first_name":"Silvia","last_name":"Comani","domain_name":"unich-it","page_name":"SilviaComani","display_name":"Silvia Comani","profile_url":"https://unich-it.academia.edu/SilviaComani?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_51092746 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="51092746"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 51092746, container: ".js-paper-rank-work_51092746", }); 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$(".js-view-count[data-work-id=51092746]").text(description); $(".js-view-count-work_51092746").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_51092746").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="51092746"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="62550" rel="nofollow" href="https://www.academia.edu/Documents/in/Pregnancy">Pregnancy</a>, <script data-card-contents-for-ri="62550" type="text/json">{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="131495" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart">Heart</a>, <script data-card-contents-for-ri="131495" type="text/json">{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="175658" rel="nofollow" href="https://www.academia.edu/Documents/in/Myocarditis">Myocarditis</a>, <script data-card-contents-for-ri="175658" type="text/json">{"id":175658,"name":"Myocarditis","url":"https://www.academia.edu/Documents/in/Myocarditis?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="313024" rel="nofollow" href="https://www.academia.edu/Documents/in/Electromagnetic_phenomena">Electromagnetic phenomena</a><script data-card-contents-for-ri="313024" type="text/json">{"id":313024,"name":"Electromagnetic phenomena","url":"https://www.academia.edu/Documents/in/Electromagnetic_phenomena?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=51092746]'), work: {"id":51092746,"title":"Magnetocardiography: current status and perspectives. Part II: Clinical applications","created_at":"2021-08-30T02:51:54.239-07:00","url":"https://www.academia.edu/51092746/Magnetocardiography_current_status_and_perspectives_Part_II_Clinical_applications?f_ri=893785","dom_id":"work_51092746","summary":"Magnetocardiography (MCG) is a non-invasive and risk-free technique allowing body surface recording of the magnetic fields generated by the electrical activity of the heart. The MCG recording system allows spatially and temporally accurate measurements of the very weak magnetic fields produced by currents flowing within myocardial fibers during cardiac activity. MCG has now been around for over 30 years, but only recently has progress in instrumentation put the technique on the verge of clinical applicability. This review summarizes the physical principles, instrumentation, main clinical applications and perspectives for the clinical use of MCG. This first part is devoted to the description of the physical principles and instrumentation.","downloadable_attachments":[{"id":68943928,"asset_id":51092746,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":201874371,"first_name":"Silvia","last_name":"Comani","domain_name":"unich-it","page_name":"SilviaComani","display_name":"Silvia Comani","profile_url":"https://unich-it.academia.edu/SilviaComani?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=893785","nofollow":true},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=893785","nofollow":true},{"id":175658,"name":"Myocarditis","url":"https://www.academia.edu/Documents/in/Myocarditis?f_ri=893785","nofollow":true},{"id":313024,"name":"Electromagnetic phenomena","url":"https://www.academia.edu/Documents/in/Electromagnetic_phenomena?f_ri=893785","nofollow":true},{"id":323090,"name":"Cardiac Arrhythmias","url":"https://www.academia.edu/Documents/in/Cardiac_Arrhythmias?f_ri=893785"},{"id":515631,"name":"Left ventricular hypertrophy","url":"https://www.academia.edu/Documents/in/Left_ventricular_hypertrophy?f_ri=893785"},{"id":747845,"name":"Cardiomyopathies","url":"https://www.academia.edu/Documents/in/Cardiomyopathies?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":987931,"name":"Heart Transplantation","url":"https://www.academia.edu/Documents/in/Heart_Transplantation?f_ri=893785"},{"id":1295334,"name":"Body Surface Potential Mapping","url":"https://www.academia.edu/Documents/in/Body_Surface_Potential_Mapping?f_ri=893785"},{"id":1295336,"name":"Vectorcardiography","url":"https://www.academia.edu/Documents/in/Vectorcardiography?f_ri=893785"},{"id":2207328,"name":"Heart Diseases","url":"https://www.academia.edu/Documents/in/Heart_Diseases?f_ri=893785"},{"id":2499440,"name":"cardiotocography","url":"https://www.academia.edu/Documents/in/cardiotocography?f_ri=893785"},{"id":2503388,"name":"Myocardial Ischemia","url":"https://www.academia.edu/Documents/in/Myocardial_Ischemia?f_ri=893785"},{"id":3746601,"name":"Wolff-Parkinson-White Syndrome","url":"https://www.academia.edu/Documents/in/Wolff_Parkinson_White_Syndrome?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_45195559" data-work_id="45195559" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/45195559/HLA_compatibility_and_different_features_of_liver_allograft_rejection">HLA compatibility and different features of liver allograft rejection</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The influence of human leukocyte antigen (HLA) on acute liver allograft rejection was investigated in 48 adult patients. The diagnosis of rejection was always based on the full triad of histological findings, clinical signs, and the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_45195559" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The influence of human leukocyte antigen (HLA) on acute liver allograft rejection was investigated in 48 adult patients. The diagnosis of rejection was always based on the full triad of histological findings, clinical signs, and the required antirejection treatment. Sixty-two percent of the patients closely observed for 6 months postoperatively revealed acute rejection within the first 3 weeks, mostly on days 7-11. HLA compatibility was not observed to have any significant influence on the incidence of acute rejection. However, different histological and clinical features were revealed in conjunction with DR compatibility. Patients without DR compatibility showed a type of rejection with fever and increase of bilirubin, frequently associated with cholestasis and cholangitis, which sometimes persisted for weeks. Patients with 1 DR compatibility showed a predominant increase of transaminases, which was never associated with cholangitis. The conjunction of different DR compatibilities and various clinical signs may indicate possible pathways from immunological assault to the clinical appearance of acute rejection. A knowledge of a patient's individual compatibility and an expectation of certain rejection patterns may lead to earlier and more reliable diagnosis and treatment.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/45195559" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9bfd875462ee1ca3da7be079e0f6942b" rel="nofollow" data-download="{"attachment_id":65782397,"asset_id":45195559,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/65782397/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="74596456" href="https://independent.academia.edu/GuenterTusch">Guenter Tusch</a><script data-card-contents-for-user="74596456" type="text/json">{"id":74596456,"first_name":"Guenter","last_name":"Tusch","domain_name":"independent","page_name":"GuenterTusch","display_name":"Guenter Tusch","profile_url":"https://independent.academia.edu/GuenterTusch?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_45195559 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="45195559"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 45195559, container: ".js-paper-rank-work_45195559", }); 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The diagnosis of rejection was always based on the full triad of histological findings, clinical signs, and the required antirejection treatment. Sixty-two percent of the patients closely observed for 6 months postoperatively revealed acute rejection within the first 3 weeks, mostly on days 7-11. HLA compatibility was not observed to have any significant influence on the incidence of acute rejection. However, different histological and clinical features were revealed in conjunction with DR compatibility. Patients without DR compatibility showed a type of rejection with fever and increase of bilirubin, frequently associated with cholestasis and cholangitis, which sometimes persisted for weeks. Patients with 1 DR compatibility showed a predominant increase of transaminases, which was never associated with cholangitis. The conjunction of different DR compatibilities and various clinical signs may indicate possible pathways from immunological assault to the clinical appearance of acute rejection. A knowledge of a patient's individual compatibility and an expectation of certain rejection patterns may lead to earlier and more reliable diagnosis and treatment.","downloadable_attachments":[{"id":65782397,"asset_id":45195559,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":74596456,"first_name":"Guenter","last_name":"Tusch","domain_name":"independent","page_name":"GuenterTusch","display_name":"Guenter Tusch","profile_url":"https://independent.academia.edu/GuenterTusch?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation?f_ri=893785","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785","nofollow":true},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=893785","nofollow":true},{"id":416442,"name":"Transplant","url":"https://www.academia.edu/Documents/in/Transplant?f_ri=893785","nofollow":true},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":988725,"name":"Clinical Signs","url":"https://www.academia.edu/Documents/in/Clinical_Signs?f_ri=893785"},{"id":1740532,"name":"Acute rejection","url":"https://www.academia.edu/Documents/in/Acute_rejection?f_ri=893785"},{"id":3203622,"name":"Human leukocyte antigen","url":"https://www.academia.edu/Documents/in/Human_leukocyte_antigen?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_7572268" data-work_id="7572268" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/7572268/Ice_free_cryopreservation_of_mouse_embryos_at_196_C_by_vitrification">Ice-free cryopreservation of mouse embryos at −196 °C by vitrification</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Multi-proxy approach was used to reconstruct the environmental conditions of remote lakes in the High Tatra Mountains (Slovakia) over the past few centuries (approximately 500-1000 years). Short sediment cores (*30 cm) taken from three... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_7572268" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Multi-proxy approach was used to reconstruct the environmental conditions of remote lakes in the High Tatra Mountains (Slovakia) over the past few centuries (approximately 500-1000 years). Short sediment cores (*30 cm) taken from three morphologically similar glacial lakes distributed along altitudinal gradient (subalpine to alpine conditions) were analysed for organic matter content (LOI), diatoms and chironomids. Both descriptive and correlative approaches were used for analysing stratigraphical data. Predictive canonical correspondence analysis and co-correspondence analysis were applied to directly relate physical and biological proxies to each other. The relationship between LOI and biotic proxies was inconsistent across groups and lakes. Concordant patterns in diatom and chironomid composition were found in two non-acidified lakes. Common trends in those assemblages indicated major past environmental events such as the Little Ice Age, air pollution and lake acidification. In contrast, no relationship between the composition of diatom and chironomid assemblages was found in the formerly acidified lake, suggesting different responses of assemblages to acidification. While chironomids showed shifts that are attributable to recovery, diatoms assemblage remained relatively stable throughout the uppermost layers of the sediment record. On the other hand, climatic-driven changes in assemblages detected in the deeper layers were more pronounced in diatoms than in chironomids.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7572268" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4c1ff9140221c9e2aa1debdce1971641" rel="nofollow" data-download="{"attachment_id":48418055,"asset_id":7572268,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48418055/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="4088138" href="https://independent.academia.edu/GregoryFahy">Gregory Fahy</a><script data-card-contents-for-user="4088138" type="text/json">{"id":4088138,"first_name":"Gregory","last_name":"Fahy","domain_name":"independent","page_name":"GregoryFahy","display_name":"Gregory Fahy","profile_url":"https://independent.academia.edu/GregoryFahy?f_ri=893785","photo":"https://0.academia-photos.com/4088138/1573856/1905987/s65_gregory.fahy.jpg"}</script></span></span></li><li class="js-paper-rank-work_7572268 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="7572268"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 7572268, container: ".js-paper-rank-work_7572268", }); 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Short sediment cores (*30 cm) taken from three morphologically similar glacial lakes distributed along altitudinal gradient (subalpine to alpine conditions) were analysed for organic matter content (LOI), diatoms and chironomids. Both descriptive and correlative approaches were used for analysing stratigraphical data. Predictive canonical correspondence analysis and co-correspondence analysis were applied to directly relate physical and biological proxies to each other. The relationship between LOI and biotic proxies was inconsistent across groups and lakes. Concordant patterns in diatom and chironomid composition were found in two non-acidified lakes. Common trends in those assemblages indicated major past environmental events such as the Little Ice Age, air pollution and lake acidification. In contrast, no relationship between the composition of diatom and chironomid assemblages was found in the formerly acidified lake, suggesting different responses of assemblages to acidification. 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Hypertension</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Background. The survival after lung and heart-lung transplantation for idiopathic pulmonary arterial hypertension has been reportedly the lowest among the major diagnostic categories of lung transplant recipients.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24823317" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d151bb889e37859f1a6c47bfe8fa905f" rel="nofollow" data-download="{"attachment_id":45148588,"asset_id":24823317,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45148588/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="20735473" href="https://usna.academia.edu/BruceJohnson">Bruce Johnson</a><script data-card-contents-for-user="20735473" type="text/json">{"id":20735473,"first_name":"Bruce","last_name":"Johnson","domain_name":"usna","page_name":"BruceJohnson","display_name":"Bruce Johnson","profile_url":"https://usna.academia.edu/BruceJohnson?f_ri=893785","photo":"https://0.academia-photos.com/20735473/5737692/6523939/s65_bruce.johnson.jpg"}</script></span></span></li><li class="js-paper-rank-work_24823317 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24823317"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24823317, container: ".js-paper-rank-work_24823317", }); 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The survival after lung and heart-lung transplantation for idiopathic pulmonary arterial hypertension has been reportedly the lowest among the major diagnostic categories of lung transplant recipients.","downloadable_attachments":[{"id":45148588,"asset_id":24823317,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":20735473,"first_name":"Bruce","last_name":"Johnson","domain_name":"usna","page_name":"BruceJohnson","display_name":"Bruce Johnson","profile_url":"https://usna.academia.edu/BruceJohnson?f_ri=893785","photo":"https://0.academia-photos.com/20735473/5737692/6523939/s65_bruce.johnson.jpg"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=893785","nofollow":true},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=893785","nofollow":true},{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment?f_ri=893785","nofollow":true},{"id":10882,"name":"Evolution","url":"https://www.academia.edu/Documents/in/Evolution?f_ri=893785","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785"},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=893785"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=893785"},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=893785"},{"id":33069,"name":"Probability","url":"https://www.academia.edu/Documents/in/Probability?f_ri=893785"},{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=893785"},{"id":129739,"name":"Anesthesia","url":"https://www.academia.edu/Documents/in/Anesthesia?f_ri=893785"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=893785"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=893785"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=893785"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=893785"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance?f_ri=893785"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=893785"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=893785"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=893785"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":908385,"name":"Long Term","url":"https://www.academia.edu/Documents/in/Long_Term?f_ri=893785"},{"id":1036494,"name":"Heart and Lung Transplantation","url":"https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation?f_ri=893785"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models?f_ri=893785"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14235711" data-work_id="14235711" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14235711/The_effect_of_busulphan_on_the_pharmacokinetics_of_cyclophosphamide_and_its_4_hydroxy_metabolite_time_interval_influence_on_therapeutic_efficacy_and_therapy_related_toxicity">The effect of busulphan on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite: time interval influence on therapeutic efficacy and therapy-related toxicity</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Busulphan and cyclophosphamide (Bu/CP) are widely used in preparative regimens for bone marrow transplantation. Many studies have shown a wide variation in busulphan pharmacokinetics. Moreover, higher rates of liver toxicity were reported... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14235711" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Busulphan and cyclophosphamide (Bu/CP) are widely used in preparative regimens for bone marrow transplantation. Many studies have shown a wide variation in busulphan pharmacokinetics. Moreover, higher rates of liver toxicity were reported in Bu/CP protocols than in a total body irradiation (TBI)-containing regimen. In the present paper we investigated the effect of the time interval between the last dose of busulphan and the first dose of cyclophosphamide on the pharmacokinetics of CP and its cytotoxic metabolite 4-hydroperoxycyclophosphamide (4-OHCP). Thirty-six patients undergoing bone marrow transplantation (BMT) were included in the study. We also investigated the occurrence of venoocclusive disease, mucositis and graft-versus-host disease. Ten patients conditioned with CP followed by TBI served as a control group (TBI). Twenty-six patients were conditioned with Bu/CP. The patients received Bu (1 mg/kg ؋ 4 for 4 days), followed by CP (60 mg/kg for 2 days) administered as a 1-h infusion. Patients received their CP therapy either 7-15 h (group A, n ‫؍‬ 12) or 24-50 h (group B, n ‫؍‬ 14) after the last dose of Bu. None of the patients were given phenytoin or any other drug known to enhance CP metabolism. The administration of CP less than 24 h after the last dose of Bu resulted in: (1) a significantly (P ‫؍‬ 0.003) lower clearance for cyclophosphamide was observed in group A (0.036 l/h/kg) compared to 0.055 and 0.055 l/h/kg, in the B and TBI groups, respectively; (2) significantly (P ‫؍‬ 0.002) longer elimination half-life in group A (10.93 h) than in groups B and TBI (6.87 and 7.52 h, respectively); (3) significantly (P Ͻ 0.001) lower exposure to the cytotoxic metabolite (4-OHCP), expressed as the ratio AUC 4-OHCP /AUC CP , in group A (0.0053) than that obtained in group B (0.013) and group TBI (0.012); (4) the patients in group A had a significantly (P Ͻ 0.05) higher incidence of VOD (seven of 12) than the other groups, B and TBI (2/14 and 1/10, respectively); and (5) mucositis was significantly higher in group A patients (8/12), being seen in only one patient in group B and none in the TBI group. The present study has shown that the interval between busulphan and cyclophosphamide administration can negatively affect the pharmacokinetics of cyclophosphamide and its cytotoxic metabolite. We conclude that the timing of CP administration must be considered in order to improve drug efficacy and reduce conditioning-related toxicity. Bone Marrow Transplantation 25, 915-924. Effect of busulphan on cyclophosphamide pharmacokinetics M Hassan et al Effect of busulphan on cyclophosphamide pharmacokinetics M Hassan et al</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14235711" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3c9894ec0c2e7eb4dbefb197cb50613e" rel="nofollow" data-download="{"attachment_id":44421321,"asset_id":14235711,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44421321/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33208240" href="https://su-se.academia.edu/MohamedAbdelrehim">Mohamed Abdel-Rehim</a><script data-card-contents-for-user="33208240" type="text/json">{"id":33208240,"first_name":"Mohamed","last_name":"Abdel-Rehim","domain_name":"su-se","page_name":"MohamedAbdelrehim","display_name":"Mohamed Abdel-Rehim","profile_url":"https://su-se.academia.edu/MohamedAbdelrehim?f_ri=893785","photo":"https://0.academia-photos.com/33208240/11833385/67014929/s65_mohamed.abdel-rehim.jpeg"}</script></span></span></li><li class="js-paper-rank-work_14235711 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14235711"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14235711, container: ".js-paper-rank-work_14235711", }); 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Many studies have shown a wide variation in busulphan pharmacokinetics. Moreover, higher rates of liver toxicity were reported in Bu/CP protocols than in a total body irradiation (TBI)-containing regimen. In the present paper we investigated the effect of the time interval between the last dose of busulphan and the first dose of cyclophosphamide on the pharmacokinetics of CP and its cytotoxic metabolite 4-hydroperoxycyclophosphamide (4-OHCP). Thirty-six patients undergoing bone marrow transplantation (BMT) were included in the study. We also investigated the occurrence of venoocclusive disease, mucositis and graft-versus-host disease. Ten patients conditioned with CP followed by TBI served as a control group (TBI). Twenty-six patients were conditioned with Bu/CP. The patients received Bu (1 mg/kg ؋ 4 for 4 days), followed by CP (60 mg/kg for 2 days) administered as a 1-h infusion. Patients received their CP therapy either 7-15 h (group A, n ‫؍‬ 12) or 24-50 h (group B, n ‫؍‬ 14) after the last dose of Bu. None of the patients were given phenytoin or any other drug known to enhance CP metabolism. The administration of CP less than 24 h after the last dose of Bu resulted in: (1) a significantly (P ‫؍‬ 0.003) lower clearance for cyclophosphamide was observed in group A (0.036 l/h/kg) compared to 0.055 and 0.055 l/h/kg, in the B and TBI groups, respectively; (2) significantly (P ‫؍‬ 0.002) longer elimination half-life in group A (10.93 h) than in groups B and TBI (6.87 and 7.52 h, respectively); (3) significantly (P Ͻ 0.001) lower exposure to the cytotoxic metabolite (4-OHCP), expressed as the ratio AUC 4-OHCP /AUC CP , in group A (0.0053) than that obtained in group B (0.013) and group TBI (0.012); (4) the patients in group A had a significantly (P Ͻ 0.05) higher incidence of VOD (seven of 12) than the other groups, B and TBI (2/14 and 1/10, respectively); and (5) mucositis was significantly higher in group A patients (8/12), being seen in only one patient in group B and none in the TBI group. The present study has shown that the interval between busulphan and cyclophosphamide administration can negatively affect the pharmacokinetics of cyclophosphamide and its cytotoxic metabolite. We conclude that the timing of CP administration must be considered in order to improve drug efficacy and reduce conditioning-related toxicity. Bone Marrow Transplantation 25, 915-924. Effect of busulphan on cyclophosphamide pharmacokinetics M Hassan et al Effect of busulphan on cyclophosphamide pharmacokinetics M Hassan et al","downloadable_attachments":[{"id":44421321,"asset_id":14235711,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33208240,"first_name":"Mohamed","last_name":"Abdel-Rehim","domain_name":"su-se","page_name":"MohamedAbdelrehim","display_name":"Mohamed Abdel-Rehim","profile_url":"https://su-se.academia.edu/MohamedAbdelrehim?f_ri=893785","photo":"https://0.academia-photos.com/33208240/11833385/67014929/s65_mohamed.abdel-rehim.jpeg"}],"research_interests":[{"id":11558,"name":"Drug 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therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":979632,"name":"Drug Interaction","url":"https://www.academia.edu/Documents/in/Drug_Interaction?f_ri=893785"},{"id":1198588,"name":"Cyclophosphamide","url":"https://www.academia.edu/Documents/in/Cyclophosphamide?f_ri=893785"},{"id":1521551,"name":"Graft-Versus-Host Disease","url":"https://www.academia.edu/Documents/in/Graft-Versus-Host_Disease?f_ri=893785"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group?f_ri=893785"},{"id":1979328,"name":"Total body irradiation","url":"https://www.academia.edu/Documents/in/Total_body_irradiation?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19219668" data-work_id="19219668" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19219668/Rothia_dentocariosa_sepsis_in_a_pediatric_renal_transplant_recipient_having_post_transplant_lymphoproliferative_disorders">Rothia dentocariosa sepsis in a pediatric renal transplant recipient having post-transplant lymphoproliferative disorders</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">dentocariosa sepsis in a pediatric renal transplant recipient suffering from post-transplant lymphoproliferative disorders.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19219668" data-share-source="work_strip" 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itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39447905" href="https://independent.academia.edu/ThereseJungraithmayr">Therese Jungraithmayr</a><script data-card-contents-for-user="39447905" type="text/json">{"id":39447905,"first_name":"Therese","last_name":"Jungraithmayr","domain_name":"independent","page_name":"ThereseJungraithmayr","display_name":"Therese Jungraithmayr","profile_url":"https://independent.academia.edu/ThereseJungraithmayr?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_19219668 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19219668"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 19219668, container: ".js-paper-rank-work_19219668", }); });</script></li><li class="js-percentile-work_19219668 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19219668; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_19219668"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_19219668 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="19219668"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19219668; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19219668]").text(description); $(".js-view-count-work_19219668").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_19219668").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="19219668"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="9003" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_transplantation">Kidney transplantation</a>, <script data-card-contents-for-ri="9003" type="text/json">{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" rel="nofollow" href="https://www.academia.edu/Documents/in/Child">Child</a>, <script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="125076" rel="nofollow" href="https://www.academia.edu/Documents/in/Sepsis">Sepsis</a><script data-card-contents-for-ri="125076" type="text/json">{"id":125076,"name":"Sepsis","url":"https://www.academia.edu/Documents/in/Sepsis?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=19219668]'), work: {"id":19219668,"title":"Rothia dentocariosa sepsis in a pediatric renal transplant recipient having post-transplant lymphoproliferative disorders","created_at":"2015-11-30T02:23:03.296-08:00","url":"https://www.academia.edu/19219668/Rothia_dentocariosa_sepsis_in_a_pediatric_renal_transplant_recipient_having_post_transplant_lymphoproliferative_disorders?f_ri=893785","dom_id":"work_19219668","summary":"dentocariosa sepsis in a pediatric renal transplant recipient suffering from post-transplant lymphoproliferative disorders.","downloadable_attachments":[{"id":40498229,"asset_id":19219668,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39447905,"first_name":"Therese","last_name":"Jungraithmayr","domain_name":"independent","page_name":"ThereseJungraithmayr","display_name":"Therese Jungraithmayr","profile_url":"https://independent.academia.edu/ThereseJungraithmayr?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=893785","nofollow":true},{"id":125076,"name":"Sepsis","url":"https://www.academia.edu/Documents/in/Sepsis?f_ri=893785","nofollow":true},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":962941,"name":"Nocardia","url":"https://www.academia.edu/Documents/in/Nocardia?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16975466" data-work_id="16975466" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16975466/Second_hematopoietic_SCT_in_patients_with_thalassemia_recurrence_following_rejection_of_the_first_graft">Second hematopoietic SCT in patients with thalassemia recurrence following rejection of the first graft</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">There is a substantial incidence of graft failure in patients with thalassemia after myeloablative conditioning regimens especially in class 3 patients in whom its incidence could be as high as 8-38.5%. Most patients with graft failure... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16975466" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">There is a substantial incidence of graft failure in patients with thalassemia after myeloablative conditioning regimens especially in class 3 patients in whom its incidence could be as high as 8-38.5%. Most patients with graft failure have recurrence of thalassemic marrow. Historically, results of second transplants for thalassemia were poor because of a high rejection rate and/or increased TRM. Sixteen patients with thalassemia recurrence following rejection of the first graft and with a median age of 9 years (range, 4-20) were given second transplants using BM (n ¼ 7) or PBSC (n ¼ 9) after preparation with a new treatment protocol. All but two patients received stem cells from the same donor. The median interval between two transplants was 28 months (range, 8-204). The sustained engraftment rate was high (94%) with only one patient having primary graft failure. The probability of overall survival, event-free survival, TRM and graft failure were 79, 79, 16 and 6%, respectively. There were three transplant-related deaths. Thirteen patients are alive with Lansky/Karnofsky score of 100. This intensified treatment protocol was well tolerated with no significant increase in toxicity. The excellent results obtained with this new preparative regimen allow us to recommend it for second transplantation for patients with thalassemia recurrence.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16975466" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="21b575528a399245daea8480bce85509" rel="nofollow" data-download="{"attachment_id":39287511,"asset_id":16975466,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39287511/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36494714" href="https://independent.academia.edu/JavidGaziev">Javid Gaziev</a><script data-card-contents-for-user="36494714" type="text/json">{"id":36494714,"first_name":"Javid","last_name":"Gaziev","domain_name":"independent","page_name":"JavidGaziev","display_name":"Javid Gaziev","profile_url":"https://independent.academia.edu/JavidGaziev?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16975466 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16975466"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16975466, container: ".js-paper-rank-work_16975466", }); 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$(".js-view-count[data-work-id=16975466]").text(description); $(".js-view-count-work_16975466").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16975466").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16975466"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7825" rel="nofollow" href="https://www.academia.edu/Documents/in/Thalassemia">Thalassemia</a>, <script data-card-contents-for-ri="7825" type="text/json">{"id":7825,"name":"Thalassemia","url":"https://www.academia.edu/Documents/in/Thalassemia?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="23163" rel="nofollow" href="https://www.academia.edu/Documents/in/Stem_Cell">Stem Cell</a>, <script data-card-contents-for-ri="23163" type="text/json">{"id":23163,"name":"Stem Cell","url":"https://www.academia.edu/Documents/in/Stem_Cell?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a><script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16975466]'), work: {"id":16975466,"title":"Second hematopoietic SCT in patients with thalassemia recurrence following rejection of the first graft","created_at":"2015-10-18T22:32:58.432-07:00","url":"https://www.academia.edu/16975466/Second_hematopoietic_SCT_in_patients_with_thalassemia_recurrence_following_rejection_of_the_first_graft?f_ri=893785","dom_id":"work_16975466","summary":"There is a substantial incidence of graft failure in patients with thalassemia after myeloablative conditioning regimens especially in class 3 patients in whom its incidence could be as high as 8-38.5%. Most patients with graft failure have recurrence of thalassemic marrow. Historically, results of second transplants for thalassemia were poor because of a high rejection rate and/or increased TRM. Sixteen patients with thalassemia recurrence following rejection of the first graft and with a median age of 9 years (range, 4-20) were given second transplants using BM (n ¼ 7) or PBSC (n ¼ 9) after preparation with a new treatment protocol. All but two patients received stem cells from the same donor. The median interval between two transplants was 28 months (range, 8-204). The sustained engraftment rate was high (94%) with only one patient having primary graft failure. The probability of overall survival, event-free survival, TRM and graft failure were 79, 79, 16 and 6%, respectively. There were three transplant-related deaths. Thirteen patients are alive with Lansky/Karnofsky score of 100. This intensified treatment protocol was well tolerated with no significant increase in toxicity. The excellent results obtained with this new preparative regimen allow us to recommend it for second transplantation for patients with thalassemia recurrence.","downloadable_attachments":[{"id":39287511,"asset_id":16975466,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36494714,"first_name":"Javid","last_name":"Gaziev","domain_name":"independent","page_name":"JavidGaziev","display_name":"Javid Gaziev","profile_url":"https://independent.academia.edu/JavidGaziev?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7825,"name":"Thalassemia","url":"https://www.academia.edu/Documents/in/Thalassemia?f_ri=893785","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=893785","nofollow":true},{"id":23163,"name":"Stem Cell","url":"https://www.academia.edu/Documents/in/Stem_Cell?f_ri=893785","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=893785","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=893785"},{"id":148806,"name":"Siblings","url":"https://www.academia.edu/Documents/in/Siblings?f_ri=893785"},{"id":159239,"name":"Bone marrow","url":"https://www.academia.edu/Documents/in/Bone_marrow?f_ri=893785"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=893785"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785"},{"id":354937,"name":"Bone Marrow Transplantation","url":"https://www.academia.edu/Documents/in/Bone_Marrow_Transplantation?f_ri=893785"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=893785"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1225372,"name":"Overall Survival","url":"https://www.academia.edu/Documents/in/Overall_Survival?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_66793361" data-work_id="66793361" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/66793361/Preclinical_biosafety_evaluation_of_cell_based_therapies_emerging_global_paradigms">Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cell-based therapies have the potential to treat a diversity of disease conditions, many representing significant and long-standing unmet medical needs. Certain properties of cell-based therapies, such as differentiation potential and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_66793361" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cell-based therapies have the potential to treat a diversity of disease conditions, many representing significant and long-standing unmet medical needs. Certain properties of cell-based therapies, such as differentiation potential and proliferative potential, present safety concerns uniquely distinct from those of small molecule drugs and other macromolecule biologics. These cellular products carry risks associated with localized host tissue response, long-term persistence, ectopic tissue formation, differentiation to undesirable cell and tissue types, uncontrollable biodistribution, tumorigenicity, and immunogenicity. Such risks are generally evaluated in preclinical animal model studies as part of a comprehensive safety program prior to administration in humans. However, safety assessment for these products can be challenging because of inconsistent approaches to product characterization, inadequately defined product parameters that anticipate adverse events, and the lack of stand...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/66793361" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="119bd3a5bcadcbe35fc9300717606d06" rel="nofollow" data-download="{"attachment_id":77848848,"asset_id":66793361,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77848848/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="50107848" href="https://independent.academia.edu/MahendraRao3">Mahendra Rao</a><script data-card-contents-for-user="50107848" type="text/json">{"id":50107848,"first_name":"Mahendra","last_name":"Rao","domain_name":"independent","page_name":"MahendraRao3","display_name":"Mahendra Rao","profile_url":"https://independent.academia.edu/MahendraRao3?f_ri=893785","photo":"https://0.academia-photos.com/50107848/13168802/14468614/s65_mahendra.rao.jpg"}</script></span></span></li><li class="js-paper-rank-work_66793361 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="66793361"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 66793361, container: ".js-paper-rank-work_66793361", }); 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Lysins can be secreted in the body fluids or act at the mem brane level of the effector cells. Hemocytes appear to be responsible for the cytotoxic response to... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5705590" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In invertebrates, cytotoxicity can be an efficient natural defence system. Lysins can be secreted in the body fluids or act at the mem brane level of the effector cells. Hemocytes appear to be responsible for the cytotoxic response to foreign, broad, or specific stimuli. The mechanisms by which Iysins are released and function are not yet very well characterized. The findings about cell mediated contact dependent cytotoxicity suggest that multiple mechanisms must be considered. In allo-and xenogeneic reactions the specificity of cytotoxic mechanisms have been shown. In tunicates, humoral Iysins have not been observed. Cytotoxic hemocytes, responsible for allo-and xenogeneic reactions, appear to be involved in graft rejections. Some properties of tunicate hemocyte cytotoxicity have been examined in Ciona intestinalis using erythrocyte targets. The reaction is fast, calcium-dependent, behaves sigmoidally according to temperature, reaches a maximum at 37° C, and depends on mem brane contact. Individual variability in lytic capacity of Ciona specimens suggests that, as in the other invertebrate species, not all the hemocytes are cytotoxic. Sphingomyelin capacity to inhibit the reaction shows functional analogies with the pore-forming hemolysins of echinoderm and polychaete species. However, it is not excluded that a hemocyte phospholipase may provoke the lysis of the target cell membrane. Thus the hypothesis is supported that a NK-like activity appears early in the evolution thus contributing to the maintenance of homeostasis, and developing immunity.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5705590" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7cc60566967dd3e4c26d42d3fbc62a4f" rel="nofollow" data-download="{"attachment_id":49173821,"asset_id":5705590,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49173821/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="8267166" href="https://unipa.academia.edu/VincenzoArizza">Vincenzo Arizza</a><script data-card-contents-for-user="8267166" type="text/json">{"id":8267166,"first_name":"Vincenzo","last_name":"Arizza","domain_name":"unipa","page_name":"VincenzoArizza","display_name":"Vincenzo Arizza","profile_url":"https://unipa.academia.edu/VincenzoArizza?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_5705590 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5705590"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5705590, container: ".js-paper-rank-work_5705590", }); 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Lysins can be secreted in the body fluids or act at the mem brane level of the effector cells. Hemocytes appear to be responsible for the cytotoxic response to foreign, broad, or specific stimuli. The mechanisms by which Iysins are released and function are not yet very well characterized. The findings about cell mediated contact dependent cytotoxicity suggest that multiple mechanisms must be considered. In allo-and xenogeneic reactions the specificity of cytotoxic mechanisms have been shown. In tunicates, humoral Iysins have not been observed. Cytotoxic hemocytes, responsible for allo-and xenogeneic reactions, appear to be involved in graft rejections. Some properties of tunicate hemocyte cytotoxicity have been examined in Ciona intestinalis using erythrocyte targets. The reaction is fast, calcium-dependent, behaves sigmoidally according to temperature, reaches a maximum at 37° C, and depends on mem brane contact. Individual variability in lytic capacity of Ciona specimens suggests that, as in the other invertebrate species, not all the hemocytes are cytotoxic. Sphingomyelin capacity to inhibit the reaction shows functional analogies with the pore-forming hemolysins of echinoderm and polychaete species. However, it is not excluded that a hemocyte phospholipase may provoke the lysis of the target cell membrane. Thus the hypothesis is supported that a NK-like activity appears early in the evolution thus contributing to the maintenance of homeostasis, and developing immunity.","downloadable_attachments":[{"id":49173821,"asset_id":5705590,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":8267166,"first_name":"Vincenzo","last_name":"Arizza","domain_name":"unipa","page_name":"VincenzoArizza","display_name":"Vincenzo Arizza","profile_url":"https://unipa.academia.edu/VincenzoArizza?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology?f_ri=893785","nofollow":true},{"id":382460,"name":"Cytotoxic Activity","url":"https://www.academia.edu/Documents/in/Cytotoxic_Activity?f_ri=893785","nofollow":true},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785","nofollow":true},{"id":954413,"name":"Ciona Intestinalis","url":"https://www.academia.edu/Documents/in/Ciona_Intestinalis?f_ri=893785","nofollow":true},{"id":2468093,"name":"Cell Membrane","url":"https://www.academia.edu/Documents/in/Cell_Membrane?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17767752" data-work_id="17767752" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17767752/Small_bowel_transplantation_using_grafts_from_living_related_donors_Two_case_reports">Small bowel transplantation using grafts from living-related donors. 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Two case reports","created_at":"2015-11-04T16:22:05.511-08:00","url":"https://www.academia.edu/17767752/Small_bowel_transplantation_using_grafts_from_living_related_donors_Two_case_reports?f_ri=893785","dom_id":"work_17767752","summary":null,"downloadable_attachments":[{"id":39698654,"asset_id":17767752,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37674075,"first_name":"Michihiro","last_name":"Hayashi","domain_name":"independent","page_name":"MichihiroHayashi","display_name":"Michihiro Hayashi","profile_url":"https://independent.academia.edu/MichihiroHayashi?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true},{"id":63886,"name":"Case Report","url":"https://www.academia.edu/Documents/in/Case_Report?f_ri=893785","nofollow":true},{"id":162282,"name":"Mothers","url":"https://www.academia.edu/Documents/in/Mothers?f_ri=893785","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785","nofollow":true},{"id":416442,"name":"Transplant","url":"https://www.academia.edu/Documents/in/Transplant?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1901112,"name":"Ileum","url":"https://www.academia.edu/Documents/in/Ileum?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_31542771" data-work_id="31542771" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/31542771/Everolimus_and_Minimization_of_Cyclosporine_in_Renal_Transplantation_24_Month_Follow_Up_of_the_EVEREST_Study">Everolimus and Minimization of Cyclosporine in Renal Transplantation: 24-Month Follow-Up of the EVEREST Study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">C.P. designed the research and wrote the article; M.S., M.P.S., F.C., and P.R. participated in the performance of the research; A.V. participated in the writing of the article; and M.B. com-puted statistical calculations and participated... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_31542771" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">C.P. designed the research and wrote the article; M.S., M.P.S., F.C., and P.R. participated in the performance of the research; A.V. participated in the writing of the article; and M.B. com-puted statistical calculations and participated in the writing of the article.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/31542771" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="48b85e23ddf986fa5b7c73d74490a3f7" rel="nofollow" data-download="{"attachment_id":51884020,"asset_id":31542771,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51884020/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="60423058" href="https://independent.academia.edu/AntonellaVeneziano">Antonella Veneziano</a><script data-card-contents-for-user="60423058" type="text/json">{"id":60423058,"first_name":"Antonella","last_name":"Veneziano","domain_name":"independent","page_name":"AntonellaVeneziano","display_name":"Antonella Veneziano","profile_url":"https://independent.academia.edu/AntonellaVeneziano?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_31542771 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="31542771"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 31542771, container: ".js-paper-rank-work_31542771", }); 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M.S., M.P.S., F.C., and P.R. participated in the performance of the research; A.V. participated in the writing of the article; and M.B. com-puted statistical calculations and participated in the writing of the article.","downloadable_attachments":[{"id":51884020,"asset_id":31542771,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":60423058,"first_name":"Antonella","last_name":"Veneziano","domain_name":"independent","page_name":"AntonellaVeneziano","display_name":"Antonella Veneziano","profile_url":"https://independent.academia.edu/AntonellaVeneziano?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation?f_ri=893785","nofollow":true},{"id":168352,"name":"Cyclosporine","url":"https://www.academia.edu/Documents/in/Cyclosporine?f_ri=893785","nofollow":true},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=893785"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1150115,"name":"Sirolimus","url":"https://www.academia.edu/Documents/in/Sirolimus?f_ri=893785"},{"id":2562571,"name":"Immunosuppressive Agents","url":"https://www.academia.edu/Documents/in/Immunosuppressive_Agents?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13130363" data-work_id="13130363" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13130363/Successful_haploidentical_bone_marrow_transplantation_in_Fanconi_anemia">Successful haploidentical bone marrow transplantation in Fanconi anemia</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A 10-year-old girl with Fanconi anemia and severe aplastic anemia underwent a haploidentical BMT from her mother due to lack of a matched family donor. T cell depletion was done by positive selection of CD34 cells with immunomagnetic... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13130363" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A 10-year-old girl with Fanconi anemia and severe aplastic anemia underwent a haploidentical BMT from her mother due to lack of a matched family donor. T cell depletion was done by positive selection of CD34 cells with immunomagnetic beads. Due to graft rejection a second haploidentical BMT from the father was successfully undertaken. No immunosuppression was given after the transplant. Immunological reconstitution took approximately 6 months, with no GVHD or severe infections. Such a transplant, containing a large purified CD34 cell fraction with a minimal number of added T cells, should be considered as the treatment of choice for patients with Fanconi anemia if no HLA matched donor is available. Bone Marrow Transplantation (2000) 26, 1221-1223.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13130363" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="140ebd5b43215f6a3edf79b4377e4c87" rel="nofollow" data-download="{"attachment_id":45672454,"asset_id":13130363,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45672454/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32388116" href="https://independent.academia.edu/SergeyPostovsky">Sergey Postovsky</a><script data-card-contents-for-user="32388116" type="text/json">{"id":32388116,"first_name":"Sergey","last_name":"Postovsky","domain_name":"independent","page_name":"SergeyPostovsky","display_name":"Sergey Postovsky","profile_url":"https://independent.academia.edu/SergeyPostovsky?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13130363 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13130363"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13130363, container: ".js-paper-rank-work_13130363", }); 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T cell depletion was done by positive selection of CD34 cells with immunomagnetic beads. Due to graft rejection a second haploidentical BMT from the father was successfully undertaken. No immunosuppression was given after the transplant. Immunological reconstitution took approximately 6 months, with no GVHD or severe infections. Such a transplant, containing a large purified CD34 cell fraction with a minimal number of added T cells, should be considered as the treatment of choice for patients with Fanconi anemia if no HLA matched donor is available. Bone Marrow Transplantation (2000) 26, 1221-1223.","downloadable_attachments":[{"id":45672454,"asset_id":13130363,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32388116,"first_name":"Sergey","last_name":"Postovsky","domain_name":"independent","page_name":"SergeyPostovsky","display_name":"Sergey Postovsky","profile_url":"https://independent.academia.edu/SergeyPostovsky?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":24631,"name":"Fathers","url":"https://www.academia.edu/Documents/in/Fathers?f_ri=893785","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=893785","nofollow":true},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=893785","nofollow":true},{"id":159239,"name":"Bone marrow","url":"https://www.academia.edu/Documents/in/Bone_marrow?f_ri=893785","nofollow":true},{"id":176832,"name":"Fanconi anemia","url":"https://www.academia.edu/Documents/in/Fanconi_anemia?f_ri=893785"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=893785"},{"id":280237,"name":"T lymphocytes","url":"https://www.academia.edu/Documents/in/T_lymphocytes?f_ri=893785"},{"id":301343,"name":"Positive Selection","url":"https://www.academia.edu/Documents/in/Positive_Selection?f_ri=893785"},{"id":354937,"name":"Bone Marrow Transplantation","url":"https://www.academia.edu/Documents/in/Bone_Marrow_Transplantation?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13296575" data-work_id="13296575" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13296575/Human_myoblast_transplantation_between_immunohistocompatible_donors_and_recipients_produces_immune_reactions">Human myoblast transplantation between immunohistocompatible donors and recipients produces immune reactions</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Because it is due to a mutation on the X-chromosome, Duchenne muscular dystrophy rarely affects women, unless there is an unequal lyonisation of the X-chromosome containing the normal dystrophin gene. We report here the unique situation... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13296575" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Because it is due to a mutation on the X-chromosome, Duchenne muscular dystrophy rarely affects women, unless there is an unequal lyonisation of the X-chromosome containing the normal dystrophin gene. We report here the unique situation of a symptomatic Duchenne muscular dystrophy woman who was transplanted with myoblasts received from her asymptomatic monozygotic twin sister 20 years ago. Specific dynamometry was performed to possibly detect a long-term effect of this cell therapy. Long-term safety of myoblast transplantation was established by this exceptional case. However, long-term efficacy could not be definitively asserted for this patient, in spite of several clues suggesting beneficial effects.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13296575" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c1d99aa58acd7ca42aebb3d433fbe5db" rel="nofollow" data-download="{"attachment_id":45499038,"asset_id":13296575,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45499038/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32546765" href="https://ulaval.academia.edu/CarolRichards">Carol Richards</a><script data-card-contents-for-user="32546765" type="text/json">{"id":32546765,"first_name":"Carol","last_name":"Richards","domain_name":"ulaval","page_name":"CarolRichards","display_name":"Carol Richards","profile_url":"https://ulaval.academia.edu/CarolRichards?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13296575 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13296575"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13296575, container: ".js-paper-rank-work_13296575", }); 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$(".js-view-count[data-work-id=13296575]").text(description); $(".js-view-count-work_13296575").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13296575").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13296575"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="37834" rel="nofollow" href="https://www.academia.edu/Documents/in/Western_blotting">Western blotting</a>, <script data-card-contents-for-ri="37834" type="text/json">{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="84760" rel="nofollow" href="https://www.academia.edu/Documents/in/Mice">Mice</a>, <script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="98995" rel="nofollow" href="https://www.academia.edu/Documents/in/Muscular_Dystrophies">Muscular Dystrophies</a>, <script data-card-contents-for-ri="98995" type="text/json">{"id":98995,"name":"Muscular Dystrophies","url":"https://www.academia.edu/Documents/in/Muscular_Dystrophies?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="118540" rel="nofollow" href="https://www.academia.edu/Documents/in/Immunosuppression">Immunosuppression</a><script data-card-contents-for-ri="118540" type="text/json">{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13296575]'), work: {"id":13296575,"title":"Human myoblast transplantation between immunohistocompatible donors and recipients produces immune reactions","created_at":"2015-06-25T18:16:38.052-07:00","url":"https://www.academia.edu/13296575/Human_myoblast_transplantation_between_immunohistocompatible_donors_and_recipients_produces_immune_reactions?f_ri=893785","dom_id":"work_13296575","summary":"Because it is due to a mutation on the X-chromosome, Duchenne muscular dystrophy rarely affects women, unless there is an unequal lyonisation of the X-chromosome containing the normal dystrophin gene. We report here the unique situation of a symptomatic Duchenne muscular dystrophy woman who was transplanted with myoblasts received from her asymptomatic monozygotic twin sister 20 years ago. Specific dynamometry was performed to possibly detect a long-term effect of this cell therapy. Long-term safety of myoblast transplantation was established by this exceptional case. However, long-term efficacy could not be definitively asserted for this patient, in spite of several clues suggesting beneficial effects.","downloadable_attachments":[{"id":45499038,"asset_id":13296575,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32546765,"first_name":"Carol","last_name":"Richards","domain_name":"ulaval","page_name":"CarolRichards","display_name":"Carol Richards","profile_url":"https://ulaval.academia.edu/CarolRichards?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting?f_ri=893785","nofollow":true},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=893785","nofollow":true},{"id":98995,"name":"Muscular Dystrophies","url":"https://www.academia.edu/Documents/in/Muscular_Dystrophies?f_ri=893785","nofollow":true},{"id":118540,"name":"Immunosuppression","url":"https://www.academia.edu/Documents/in/Immunosuppression?f_ri=893785","nofollow":true},{"id":134095,"name":"Muscles","url":"https://www.academia.edu/Documents/in/Muscles?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":911036,"name":"Dystrophin","url":"https://www.academia.edu/Documents/in/Dystrophin?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21350168 coauthored" data-work_id="21350168" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21350168/Alemtuzumab_Induction_in_Kidney_Transplantation_Clinical_Results_and_Impact_on_T_Regulatory_Cells">Alemtuzumab Induction in Kidney Transplantation: Clinical Results and Impact on T-Regulatory Cells</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Alemtuzumab (ALT), a humanized monoclonal anti-CD52 antibody, was introduced in solid organ transplantation as an induction agent. ALT associated with anticalcineurins has provided a low incidence of acute rejection episodes (ARE) and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21350168" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Alemtuzumab (ALT), a humanized monoclonal anti-CD52 antibody, was introduced in solid organ transplantation as an induction agent. ALT associated with anticalcineurins has provided a low incidence of acute rejection episodes (ARE) and potential tolerogenic properties. We analyzed the clinical outcomes and effects on peripheral Treg of renal transplant recipients treated with ALT. Six-month data on kidney alone or kidney combined with pancreas or liver patients treated with ALT and tacrolimus (TAC) in standard doses were compared with those on renal transplant recipients of similar demography who were not treated with ALT. We evaluated patient and graft survivals, ARE incidence, hematological parameters, renal function, adverse events, and CD4ϩCD25ϩFoxP3ϩ T cells in peripheral blood. Demographics of recipients, donors, and transplants were similar in both groups. Mean HLA mismatch was slightly greater among ALT-treated patients (3.5 vs 2.5). No combined transplantation was performed in the ALT-untreated group. Patient and graft survivals were 100% without rejection or serious infections in both groups. ALT-treated recipients showed anemia and leukopenia in 3 patients as well as severe lymphopenia in 5 recipients, who partially recovered on day 90. Final mean plasma creatinine was 1.4 mg/dL, while calculated creatinine clearance was approximately 65 mL/min in both groups. Mean Treg cell percentage was higher among ALT-treated recipients than the comparative group or healthy controls (P Ͻ .05). In conclusion, renal transplantation results obtained using ALT with rigorous immunosuppressive therapy were excellent; serious adverse events and acute rejection were absent. The effect of the increased proportion of Treg cells must be evaluated with longer observation.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21350168" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c8be615a45ad1c6f003ba8ea1c6830b9" rel="nofollow" data-download="{"attachment_id":41828208,"asset_id":21350168,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41828208/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42439922" href="https://uchile.academia.edu/MarioFerrario">Mario Ferrario</a><script data-card-contents-for-user="42439922" type="text/json">{"id":42439922,"first_name":"Mario","last_name":"Ferrario","domain_name":"uchile","page_name":"MarioFerrario","display_name":"Mario Ferrario","profile_url":"https://uchile.academia.edu/MarioFerrario?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-21350168">+2</span><div class="hidden js-additional-users-21350168"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/AndreaAlba3">Andrea Alba</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/CarlosZehnder">Carlos Zehnder</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-21350168'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-21350168').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21350168 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21350168"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21350168; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21350168]").text(description); $(".js-view-count-work_21350168").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21350168").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21350168"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="8999" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_diseases">Kidney diseases</a>, <script data-card-contents-for-ri="8999" type="text/json">{"id":8999,"name":"Kidney diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9003" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_transplantation">Kidney transplantation</a>, <script data-card-contents-for-ri="9003" type="text/json">{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="51530" rel="nofollow" href="https://www.academia.edu/Documents/in/Transplantation">Transplantation</a><script data-card-contents-for-ri="51530" type="text/json">{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21350168]'), work: {"id":21350168,"title":"Alemtuzumab Induction in Kidney Transplantation: Clinical Results and Impact on T-Regulatory Cells","created_at":"2016-01-31T18:47:28.156-08:00","url":"https://www.academia.edu/21350168/Alemtuzumab_Induction_in_Kidney_Transplantation_Clinical_Results_and_Impact_on_T_Regulatory_Cells?f_ri=893785","dom_id":"work_21350168","summary":"Alemtuzumab (ALT), a humanized monoclonal anti-CD52 antibody, was introduced in solid organ transplantation as an induction agent. ALT associated with anticalcineurins has provided a low incidence of acute rejection episodes (ARE) and potential tolerogenic properties. We analyzed the clinical outcomes and effects on peripheral Treg of renal transplant recipients treated with ALT. Six-month data on kidney alone or kidney combined with pancreas or liver patients treated with ALT and tacrolimus (TAC) in standard doses were compared with those on renal transplant recipients of similar demography who were not treated with ALT. We evaluated patient and graft survivals, ARE incidence, hematological parameters, renal function, adverse events, and CD4ϩCD25ϩFoxP3ϩ T cells in peripheral blood. Demographics of recipients, donors, and transplants were similar in both groups. Mean HLA mismatch was slightly greater among ALT-treated patients (3.5 vs 2.5). No combined transplantation was performed in the ALT-untreated group. Patient and graft survivals were 100% without rejection or serious infections in both groups. ALT-treated recipients showed anemia and leukopenia in 3 patients as well as severe lymphopenia in 5 recipients, who partially recovered on day 90. Final mean plasma creatinine was 1.4 mg/dL, while calculated creatinine clearance was approximately 65 mL/min in both groups. Mean Treg cell percentage was higher among ALT-treated recipients than the comparative group or healthy controls (P Ͻ .05). In conclusion, renal transplantation results obtained using ALT with rigorous immunosuppressive therapy were excellent; serious adverse events and acute rejection were absent. The effect of the increased proportion of Treg cells must be evaluated with longer observation.","downloadable_attachments":[{"id":41828208,"asset_id":21350168,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42439922,"first_name":"Mario","last_name":"Ferrario","domain_name":"uchile","page_name":"MarioFerrario","display_name":"Mario Ferrario","profile_url":"https://uchile.academia.edu/MarioFerrario?f_ri=893785","photo":"/images/s65_no_pic.png"},{"id":42500173,"first_name":"Andrea","last_name":"Alba","domain_name":"independent","page_name":"AndreaAlba3","display_name":"Andrea Alba","profile_url":"https://independent.academia.edu/AndreaAlba3?f_ri=893785","photo":"/images/s65_no_pic.png"},{"id":42465870,"first_name":"Carlos","last_name":"Zehnder","domain_name":"independent","page_name":"CarlosZehnder","display_name":"Carlos Zehnder","profile_url":"https://independent.academia.edu/CarlosZehnder?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":8999,"name":"Kidney diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases?f_ri=893785","nofollow":true},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=893785","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=893785","nofollow":true},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation?f_ri=893785","nofollow":true},{"id":57818,"name":"Tacrolimus","url":"https://www.academia.edu/Documents/in/Tacrolimus?f_ri=893785"},{"id":58379,"name":"Renal transplantation","url":"https://www.academia.edu/Documents/in/Renal_transplantation?f_ri=893785"},{"id":108409,"name":"Organ Transplantation","url":"https://www.academia.edu/Documents/in/Organ_Transplantation?f_ri=893785"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies?f_ri=893785"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation?f_ri=893785"},{"id":191439,"name":"Glycoproteins","url":"https://www.academia.edu/Documents/in/Glycoproteins?f_ri=893785"},{"id":227354,"name":"Renal Function","url":"https://www.academia.edu/Documents/in/Renal_Function?f_ri=893785"},{"id":379033,"name":"Kidney Transplant","url":"https://www.academia.edu/Documents/in/Kidney_Transplant?f_ri=893785"},{"id":425873,"name":"Adverse Event","url":"https://www.academia.edu/Documents/in/Adverse_Event?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":1178952,"name":"Pancreas Transplantation","url":"https://www.academia.edu/Documents/in/Pancreas_Transplantation?f_ri=893785"},{"id":1482586,"name":"Autoantibodies","url":"https://www.academia.edu/Documents/in/Autoantibodies?f_ri=893785"},{"id":1740532,"name":"Acute rejection","url":"https://www.academia.edu/Documents/in/Acute_rejection?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17938985 coauthored" data-work_id="17938985" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17938985/Leeches_Immune_Response_Angiogenesis_and_Biomedical_Applications">Leeches: Immune Response, Angiogenesis and Biomedical Applications</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The innate immune response is the first line of defence strategies in invertebrates against attack of infectious agents. A detailed analysis of the immune mechanisms involved in annelids has been performed in oligochaets, but few data are... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17938985" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The innate immune response is the first line of defence strategies in invertebrates against attack of infectious agents. A detailed analysis of the immune mechanisms involved in annelids has been performed in oligochaets, but few data are available in polichaets and hirudineans.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17938985" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ddce28097ee281eb73afd047885c19aa" rel="nofollow" data-download="{"attachment_id":39789160,"asset_id":17938985,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39789160/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37853598" href="https://independent.academia.edu/CooperEdwin">Edwin Cooper</a><script data-card-contents-for-user="37853598" type="text/json">{"id":37853598,"first_name":"Edwin","last_name":"Cooper","domain_name":"independent","page_name":"CooperEdwin","display_name":"Edwin Cooper","profile_url":"https://independent.academia.edu/CooperEdwin?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-17938985">+1</span><div class="hidden js-additional-users-17938985"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/GianlucaTettamanti">Gianluca Tettamanti</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-17938985'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-17938985').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_17938985 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17938985"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17938985, container: ".js-paper-rank-work_17938985", }); });</script></li><li class="js-percentile-work_17938985 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17938985; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_17938985"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_17938985 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="17938985"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17938985; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17938985]").text(description); $(".js-view-count-work_17938985").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_17938985").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="17938985"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="2702" rel="nofollow" href="https://www.academia.edu/Documents/in/Immune_response">Immune response</a>, <script data-card-contents-for-ri="2702" type="text/json">{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8991" rel="nofollow" href="https://www.academia.edu/Documents/in/Wound_Healing">Wound Healing</a>, <script data-card-contents-for-ri="8991" type="text/json">{"id":8991,"name":"Wound Healing","url":"https://www.academia.edu/Documents/in/Wound_Healing?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="281437" rel="nofollow" href="https://www.academia.edu/Documents/in/Leeches">Leeches</a>, <script data-card-contents-for-ri="281437" type="text/json">{"id":281437,"name":"Leeches","url":"https://www.academia.edu/Documents/in/Leeches?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="893785" rel="nofollow" href="https://www.academia.edu/Documents/in/Graft_Rejection">Graft Rejection</a><script data-card-contents-for-ri="893785" type="text/json">{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=17938985]'), work: {"id":17938985,"title":"Leeches: Immune Response, Angiogenesis and Biomedical Applications","created_at":"2015-11-07T21:07:47.081-08:00","url":"https://www.academia.edu/17938985/Leeches_Immune_Response_Angiogenesis_and_Biomedical_Applications?f_ri=893785","dom_id":"work_17938985","summary":"The innate immune response is the first line of defence strategies in invertebrates against attack of infectious agents. A detailed analysis of the immune mechanisms involved in annelids has been performed in oligochaets, but few data are available in polichaets and hirudineans.","downloadable_attachments":[{"id":39789160,"asset_id":17938985,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37853598,"first_name":"Edwin","last_name":"Cooper","domain_name":"independent","page_name":"CooperEdwin","display_name":"Edwin Cooper","profile_url":"https://independent.academia.edu/CooperEdwin?f_ri=893785","photo":"/images/s65_no_pic.png"},{"id":24629533,"first_name":"Gianluca","last_name":"Tettamanti","domain_name":"independent","page_name":"GianlucaTettamanti","display_name":"Gianluca Tettamanti","profile_url":"https://independent.academia.edu/GianlucaTettamanti?f_ri=893785","photo":"https://0.academia-photos.com/24629533/6660068/7525670/s65_gianluca.tettamanti.jpg_oh_d15264c803d428cfd7e037121bc45431_oe_55316205___gda___1429635226_6b37231fdc0720d85e56d05095c46998"}],"research_interests":[{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response?f_ri=893785","nofollow":true},{"id":8991,"name":"Wound Healing","url":"https://www.academia.edu/Documents/in/Wound_Healing?f_ri=893785","nofollow":true},{"id":281437,"name":"Leeches","url":"https://www.academia.edu/Documents/in/Leeches?f_ri=893785","nofollow":true},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785","nofollow":true},{"id":1267724,"name":"Biomedical Application","url":"https://www.academia.edu/Documents/in/Biomedical_Application?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17767760 coauthored" data-work_id="17767760" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17767760/AUXILIARY_PARTIAL_ORTHOTOPIC_LIVING_DONOR_LIVER_TRANSPLANTATION_AS_AN_AID_FOR_SMALL_FOR_SIZE_GRAFTS_IN_LARGER_RECIPIENTS1_2">AUXILIARY PARTIAL ORTHOTOPIC LIVING DONOR LIVER TRANSPLANTATION AS AN AID FOR SMALL-FOR-SIZE GRAFTS IN LARGER RECIPIENTS1,2</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background. In countries where living donors are the only source of liver grafts, restrictions on graft size are a serious obstacle for the expansion of indications for adult recipients. To overcome this problem, auxiliary partial... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17767760" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background. In countries where living donors are the only source of liver grafts, restrictions on graft size are a serious obstacle for the expansion of indications for adult recipients. To overcome this problem, auxiliary partial orthotopic liver transplants (APOLT*) was performed on the basis of the concept that the residual native liver would support the graft function until the graft had grown enough to function by itself.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17767760" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0057165e87275cbb97a95ea2b5fa73ff" rel="nofollow" data-download="{"attachment_id":39698656,"asset_id":17767760,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39698656/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37674075" href="https://independent.academia.edu/MichihiroHayashi">Michihiro Hayashi</a><script data-card-contents-for-user="37674075" type="text/json">{"id":37674075,"first_name":"Michihiro","last_name":"Hayashi","domain_name":"independent","page_name":"MichihiroHayashi","display_name":"Michihiro Hayashi","profile_url":"https://independent.academia.edu/MichihiroHayashi?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-17767760">+1</span><div class="hidden js-additional-users-17767760"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/HirotoEgawa">Hiroto Egawa</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-17767760'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-17767760').html(); 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In countries where living donors are the only source of liver grafts, restrictions on graft size are a serious obstacle for the expansion of indications for adult recipients. To overcome this problem, auxiliary partial orthotopic liver transplants (APOLT*) was performed on the basis of the concept that the residual native liver would support the graft function until the graft had grown enough to function by itself.","downloadable_attachments":[{"id":39698656,"asset_id":17767760,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37674075,"first_name":"Michihiro","last_name":"Hayashi","domain_name":"independent","page_name":"MichihiroHayashi","display_name":"Michihiro Hayashi","profile_url":"https://independent.academia.edu/MichihiroHayashi?f_ri=893785","photo":"/images/s65_no_pic.png"},{"id":37789504,"first_name":"Hiroto","last_name":"Egawa","domain_name":"independent","page_name":"HirotoEgawa","display_name":"Hiroto Egawa","profile_url":"https://independent.academia.edu/HirotoEgawa?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=893785","nofollow":true},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation?f_ri=893785","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=893785","nofollow":true},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation?f_ri=893785","nofollow":true},{"id":178062,"name":"Bilirubin","url":"https://www.academia.edu/Documents/in/Bilirubin?f_ri=893785"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=893785"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_28257648" data-work_id="28257648" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28257648/Quilty_in_biopsy_is_associated_with_poor_prognosis_after_heart_transplantation">Quilty in biopsy is associated with poor prognosis after heart transplantation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We tested if Quilty (endocardial infiltration of lymphocytes) in routinely processed endomyocardial biopsy is associated with poor outcome after heart transplantation (HTx). Biopsies (n = 9829) harvested within the first post-transplant... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_28257648" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We tested if Quilty (endocardial infiltration of lymphocytes) in routinely processed endomyocardial biopsy is associated with poor outcome after heart transplantation (HTx). Biopsies (n = 9829) harvested within the first post-transplant year from 938 patients (778 men, mean age 49 years) were evaluated for Quilty and acute cellular rejection (according to the International Society for Heart and Lung Transplantation, ISHLT, classification). Transplant vasculopathy was evaluated by coronary angiography, and severe stenosis was found in 19% of patients. Survival was tested by Kaplan-Meier and Cox regression analyses for all-cause mortality and major cardiac events (lethal acute cellular rejection, graft loss or myocardial infarction). We found 1840 (19%) Quilty-positive biopsies in 487 Quilty-positive patients (52%). Quilty was more prevalent in women (p = 0.038) and younger men (p = 0.001), and was correlated with ISHLT grade 1R (OR 1.45, 95% CI 1.36-1.55; p b 0.001) and ISHLT grade 2R (OR 2.48, 95% CI 2.21-3.41; p b 0.001). Quilty in any biopsy was associated with a higher all-cause mortality (log rank p = 0.045) due to a higher risk for major cardiac event (p = 0.0001). Multivariate regression analysis showed Quilty (RR 1.69, 95%CI 1.05-2.73) and transplant vasculopathy (RR 2.78, 95%CI 1.68-4.61) as risk factors for major cardiac events and treated hyperlipidemia as lowering the risk for major cardiac events (RR 0.47, 95%CI 0.28-0.77). Quilty is associated with graft loss and poor outcome post HTx. Index biopsy during the first post-transplant year is a useful tool to identify patients at risk and is recommended during routine post-transplant management.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/28257648" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a4ad5f7e527183a69222bb9350eb35f7" rel="nofollow" data-download="{"attachment_id":48580013,"asset_id":28257648,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48580013/download_file?st=MTczOTg3MzY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35111808" href="https://independent.academia.edu/ErnstWellnhofer">Ernst Wellnhofer</a><script data-card-contents-for-user="35111808" type="text/json">{"id":35111808,"first_name":"Ernst","last_name":"Wellnhofer","domain_name":"independent","page_name":"ErnstWellnhofer","display_name":"Ernst Wellnhofer","profile_url":"https://independent.academia.edu/ErnstWellnhofer?f_ri=893785","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_28257648 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="28257648"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 28257648, container: ".js-paper-rank-work_28257648", }); 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$(".js-view-count[data-work-id=28257648]").text(description); $(".js-view-count-work_28257648").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_28257648").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="28257648"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="10610" rel="nofollow" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12069" rel="nofollow" href="https://www.academia.edu/Documents/in/Histology">Histology</a>, <script data-card-contents-for-ri="12069" type="text/json">{"id":12069,"name":"Histology","url":"https://www.academia.edu/Documents/in/Histology?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37826" rel="nofollow" href="https://www.academia.edu/Documents/in/Biopsy">Biopsy</a>, <script data-card-contents-for-ri="37826" type="text/json">{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy?f_ri=893785","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="75348" rel="nofollow" href="https://www.academia.edu/Documents/in/Cox_Regression">Cox Regression</a><script data-card-contents-for-ri="75348" type="text/json">{"id":75348,"name":"Cox Regression","url":"https://www.academia.edu/Documents/in/Cox_Regression?f_ri=893785","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=28257648]'), work: {"id":28257648,"title":"Quilty in biopsy is associated with poor prognosis after heart transplantation","created_at":"2016-09-05T00:56:54.703-07:00","url":"https://www.academia.edu/28257648/Quilty_in_biopsy_is_associated_with_poor_prognosis_after_heart_transplantation?f_ri=893785","dom_id":"work_28257648","summary":"We tested if Quilty (endocardial infiltration of lymphocytes) in routinely processed endomyocardial biopsy is associated with poor outcome after heart transplantation (HTx). Biopsies (n = 9829) harvested within the first post-transplant year from 938 patients (778 men, mean age 49 years) were evaluated for Quilty and acute cellular rejection (according to the International Society for Heart and Lung Transplantation, ISHLT, classification). Transplant vasculopathy was evaluated by coronary angiography, and severe stenosis was found in 19% of patients. Survival was tested by Kaplan-Meier and Cox regression analyses for all-cause mortality and major cardiac events (lethal acute cellular rejection, graft loss or myocardial infarction). We found 1840 (19%) Quilty-positive biopsies in 487 Quilty-positive patients (52%). Quilty was more prevalent in women (p = 0.038) and younger men (p = 0.001), and was correlated with ISHLT grade 1R (OR 1.45, 95% CI 1.36-1.55; p b 0.001) and ISHLT grade 2R (OR 2.48, 95% CI 2.21-3.41; p b 0.001). Quilty in any biopsy was associated with a higher all-cause mortality (log rank p = 0.045) due to a higher risk for major cardiac event (p = 0.0001). Multivariate regression analysis showed Quilty (RR 1.69, 95%CI 1.05-2.73) and transplant vasculopathy (RR 2.78, 95%CI 1.68-4.61) as risk factors for major cardiac events and treated hyperlipidemia as lowering the risk for major cardiac events (RR 0.47, 95%CI 0.28-0.77). Quilty is associated with graft loss and poor outcome post HTx. Index biopsy during the first post-transplant year is a useful tool to identify patients at risk and is recommended during routine post-transplant management.","downloadable_attachments":[{"id":48580013,"asset_id":28257648,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35111808,"first_name":"Ernst","last_name":"Wellnhofer","domain_name":"independent","page_name":"ErnstWellnhofer","display_name":"Ernst Wellnhofer","profile_url":"https://independent.academia.edu/ErnstWellnhofer?f_ri=893785","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=893785","nofollow":true},{"id":12069,"name":"Histology","url":"https://www.academia.edu/Documents/in/Histology?f_ri=893785","nofollow":true},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy?f_ri=893785","nofollow":true},{"id":75348,"name":"Cox 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Angiography","url":"https://www.academia.edu/Documents/in/Coronary_Angiography?f_ri=893785"},{"id":416442,"name":"Transplant","url":"https://www.academia.edu/Documents/in/Transplant?f_ri=893785"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=893785"},{"id":525017,"name":"Multivariate Regression","url":"https://www.academia.edu/Documents/in/Multivariate_Regression?f_ri=893785"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=893785"},{"id":749302,"name":"Indexation","url":"https://www.academia.edu/Documents/in/Indexation?f_ri=893785"},{"id":868560,"name":"Lymphocytes","url":"https://www.academia.edu/Documents/in/Lymphocytes?f_ri=893785"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=893785"},{"id":987931,"name":"Heart Transplantation","url":"https://www.academia.edu/Documents/in/Heart_Transplantation?f_ri=893785"}]}, }) } 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