CINXE.COM

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normal capacity of a patient's immune system to treat a wide range of disorders including cancer, autoimmune diseases and organ rejection. All immune cell therapies are examples of adoptive cell transfer (ACT), where cells are taken from a patient, modified and/or expanded, then transfused back into the patient.</p> <div class="tabbed_content"> <div class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="products" id="pharm_tabs_products"> <span>Research Areas</span></div> </div> <div class="tab_content tab_1 tab_open" data-tab="1"> <div class="pharm_sub_cats"><h3>Immune Cell Therapy Product Areas</h3><ul class="tile_column_1"><li><a href="/pharmacology/akt-protein-kinase-b" title="Browse products for Akt (Protein Kinase B)">Akt (Protein Kinase B)</a></li><li><a href="/product-type/crispr-reagents" title="Browse products for CRISPR Reagents">CRISPR Reagents</a></li><li><a href="/cell-biology/cytokine-and-nf-kappab-signaling" title="Browse products for Cytokine and NF-κB Signaling">Cytokine and NF-κB Signaling</a></li><li><a href="/product-type/gmp-ancillary-material-grade-small-molecules" title="Browse products for GMP & Ancillary Material Grade Small Molecules">GMP & Ancillary Material Grade Small Molecules</a></li></ul><ul class="tile_column_2"><li><a href="/cell-biology/immune-checkpoints" title="Browse products for Immune Checkpoints">Immune Checkpoints</a></li><li><a href="/pharmacology/mtor" title="Browse products for mTOR">mTOR</a></li><li><a href="/pharmacology/pi-3-kinase" title="Browse products for PI 3-kinase">PI 3-kinase</a></li><li><a href="/product-type/viral-transduction-enhancers" title="Browse products for Viral Transduction Enhancers">Viral Transduction Enhancers</a></li></ul></div> <div class="pharm_long_desc"><h4>CAR T-cell Therapy</h4> <p>Chimeric Antigen Receptor (CAR) T cell therapies involve the genetic modification of a patient's T cells, which play important roles in immune response organization and killing of pathogenic cells, to express a CAR specific for a tumor antigen. The CAR protein is a fusion of a single chain fragment of a monoclonal antibody, and one or more T cell receptor intracellular signaling domains. This protein, when expressed via viral transduction, CRISPR-Cas9 or direct transfer of mRNA, enables T cells to recognise a specific protein on tumor cells. Once expanded <em>ex vivo</em>, T cells are transfused back into the patient, where they recognize and kill <a href='/research-area/cancer-research' title='View cancer research areas and research products'>cancer</a> cells with high specificity.</p> <p>Acute Lymphoblastic Leukemia (ALL) in children and young adults, is an example of where CAR T-cell therapy has shown success. A clinical trial using CD19-targeting CAR T cells resulted in a complete response, with all signs of cancer abolished in 27 of 30 patients in the trial. Following larger and longer clinical trials, in which patients showed long-lasting remission, this therapy has now been approved by the FDA.</p> <h4>NK Cell Therapy</h4> <p>Natural Killer (NK) cells are immune cells with an inherent ability to kill cells without previous sensitization. Their activation is tightly controlled to prevent damage to 'self' tissues, through the integration of pro- and anti-inflammatory signalling pathways. Their role on the front line of immune response and rapid response make NK cells attractive for cell-based therapies. As with other cell therapies, NK cells can be extracted from a patient and the population expanded <em>ex vivo</em> using cytokines and feeder cells. NK cells for therapy can also be derived from <a href='/cell-biology/stem-cells' title='View stem cells reasearch and products'>stem cells</a>, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).</p> <p>Similar to CAR T cell therapies, NK cells can be genetically modified prior to transfusion into a patient. The aim of this is to enable NK cells to detect a tumor specific antigen, increasing target specificity. NK cells are relatively resistant to retroviral transfer, although the efficiency of transfer can be enhanced with small molecules targeting the TBK1/IKKε complex, for example. Alternatively, electroporation can be used for gene transfer.</p> <p>In cancer, both autologous and allogeneic NK cells are under investigation, with the most promising results shown in blood cancers such as leukemia and lymphoma. NK cell therapy is also being investigated for melanomas and other solid tumors.</p> <h4>T<sub>reg</sub> Cell Therapy</h4> <p>Regulatory T cells (T<sub>reg</sub>) are peripheral blood lymphocytes that are involved in the control of 'self' tolerance, tissue inflammation and long-term immune system homeostasis. In autoimmune disorders, the number of T<sub>reg</sub> cells is reduced, and their function in impaired, leading to misrecognition and immune response to 'self' tissues. Exogenous stabilizing factors, such as <a href='/products/rapamycin_1292' target='_blank' title='View Rapamycin'>Rapamycin</a>, can enhance T<sub>reg</sub> function in autoimmune diseases and Graft vs Host Disease (GvHD). The enhancement of T<sub>reg</sub> function is also the goal of T<sub>reg</sub>-based ACT therapies.</p> <p>The first preclinical investigations into T<sub>reg</sub> cell therapies were performed with polyclonal T<sub>regs</sub> cells that are not specific for a single antigen. These cells were isolated based on expression of multiple cell markers. Purified FOXP3<sup>+</sup> T<sub>regs</sub> have been investigated for the treatment of GvHD and type I diabetes. Cells were purified from blood, grown <em>ex vivo</em> in the presence of antibodies against CD3 and CD28 with high concentrations of IL-2 to expand a highly enriched population of T<sub>regs</sub>.</p> <p>Monoclonal T<sub>reg</sub> cells, i.e. those that are specific for a particular antigen, are more likely to be effective in autoimmune disorders against a single cell type, for example multiple sclerosis (MS). They have also shown efficacy in the treatment of organ rejection. T<sub>regs</sub> isolated from an organ transplant recipient are stimulated with antigen-presenting cells from the donor organ to expand a population of donor tissue specific T<sub>regs</sub>. These cells have been shown to be more effective at suppressing organ rejection than polyclonal T<sub>regs</sub>.</p></div> </div> <div class="tab_content tab_2" data-tab="2"> </div> <div class="tab_content tab_3" data-tab="3"> </div> <div class="tab_content tab_4" data-tab="4"> </div> <div class="tab_content tab_5" data-tab="5"> </div> <div class="tab_content tab_6" data-tab="6"> </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="resources_sidebar_container"> <div class="fp_four_box"> <div class="fp_box_wrapper"><h3>Featured New Products</h3> <div class="fp_featured_product"><a href="/products/vu-0542270_8151">8151 | VU 0542270</a><br /> Selective inhibitor of K<sub>ir</sub>6.1 K<sub>ATP</sub> channels</div> <div class="fp_featured_product"><a href="/products/rna-imaging-probe-1c_8813">8813 | RNA Imaging Probe 1c</a><br /> Fluorogenic RNA imaging probe</div> <div class="fp_featured_product"><a 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