CINXE.COM

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<h1>Tocriscreen™ Compound Libraries</h1> <p>The Tocriscreen™ range of bioactive compound libraries are collections of compounds designed for use in screening assays for receptor de-orphaning, target validation, drug re-profiling, tool compound identification and also assay development. Comprised of high-purity compounds selected from the Tocris catalog, these libraries provide wide coverage of cellular targets, including GPCRs, ion channels, kinases, enzymes, nuclear receptors and transporters.</p> <p>If the libraries listed below do not suit your needs, then please get in touch through our Tocriscreen PRO custom compound library service to discuss your requirements. To request the detailed compound lists for any of the Tocriscreen compound libraries, please complete the compound library inquiry form.</p> <ul class='tile_column_1'> <li><a href='/about-tocris/tocriscreen-pro-custom-compound-library-service' title='Tocriscreen PRO Custom Compound Library Service with Cherry Picking Available'>Tocriscreen PRO Custom Compound Library Service</a></li> </ul> <ul class='tile_column_2'> <li><a href='/support/screening-inquiry' title='Request Compound List or Submit a Custom Library Request'>Compound Library Inquiry Form</a></li> </ul> <p></p> <div class="tabbed_content"> <div class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="products" id="pharm_tabs_products"> <span>Products</span></div> <div class="tab tab_2" data-tab="2" data-tabname="background" id="pharm_tabs_background"><span>Background</span> </div> <div class="tab tab_4" data-tab="4" data-tabname="literature" id="pharm_tabs_literature"><span>Literature (1)</span> </div> </div> <div class="tab_content tab_1 tab_open" data-tab="1"> <div class="pharm_products"><table class="pharm_prod_table table table-condensed"> <tr> <td colspan="2"><h3>Libraries</h3></td> </tr> <tr> <th>Cat. No.</th> <th>Product Name / Activity</th> </tr> <tr> <td>7150</td> <td><a href="/products/tocriscreen-2-0-max_7150" title="View price & availability information for Tocriscreen 2.0 Max">Tocriscreen 2.0 Max</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Bioactive compound library for high-throughput screening, high-content screening, target validation and assay development; comprised of 1280 biologically active compounds (250 渭L 10 mM DMSO solutions)</td> </tr> <tr> <td>7152</td> <td><a href="/products/tocriscreen-2-0-micro_7152" title="View price & availability information for Tocriscreen 2.0 Micro">Tocriscreen 2.0 Micro</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Bioactive compound library for high-throughput screening, high-content screening, target validation and assay development; comprised of 1280 biologically active compounds (15 渭L 10 mM DMSO solutions)</td> </tr> <tr> <td>7151</td> <td><a href="/products/tocriscreen-2-0-mini_7151" title="View price & availability information for Tocriscreen 2.0 Mini">Tocriscreen 2.0 Mini</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Bioactive compound library for high-throughput screening, high-content screening, target validation and assay development; comprised of 1280 compounds (50 渭L 10 mM DMSO solutions)</td> </tr> <tr> <td>7350</td> <td><a href="/products/tocriscreen-antiviral-library_7350" title="View price & availability information for Tocriscreen Antiviral Library">Tocriscreen Antiviral Library</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Antiviral compound library for high throughput screening, target validation, assay development and drug repurposing; contains 240 bioactive compounds (100 渭L 10 mM DMSO solutions)</td> </tr> <tr> <td>7578</td> <td><a href="/products/tocriscreen-epigenetics-3-0_7578" title="View price & availability information for Tocriscreen Epigenetics 3.0">Tocriscreen Epigenetics 3.0</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>A library of 160 epigenetic compounds (100 渭L, 10 mM DMSO solutions) for high throughput screening, high content screening, target validation and assay development</td> </tr> <tr> <td>7200</td> <td><a href="/products/tocriscreen-fda-approved-drugs_7200" title="View price & availability information for Tocriscreen FDA-Approved Drugs Library">Tocriscreen FDA-Approved Drugs Library</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Drug repurposing library; a library of 190 compounds equivalent to active components of drug formulations approved by the FDA (100 渭L 10 mM DMSO solutions)</td> </tr> <tr> <td>8100</td> <td><a href="/products/tocriscreen-gpcr-compound-library_8100" title="View price & availability information for Tocriscreen GPCR Compound Library">Tocriscreen GPCR Compound Library</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>A bioactive compound library of 240 GPCR compounds (100 渭L 10 mM DMSO solutions) for high-throughput screening, high-content screening, target validation and assay development</td> </tr> <tr> <td>7844</td> <td><a href="/products/tocriscreen-kinase-inhibitor_7844" title="View price & availability information for Tocriscreen Kinase Inhibitor 3.0">Tocriscreen Kinase Inhibitor 3.0</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>A bioactive compound library of 210 kinase inhibitors (100 渭L 10 mM DMSO solutions) for high-throughput screening, high-content screening, target validation and assay development</td> </tr> <tr> <td>7340</td> <td><a href="/products/tocriscreen-stem-cell-library_7340" title="View price & availability information for Tocriscreen Stem Cell Library">Tocriscreen Stem Cell Library</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>A library of 120 stem cell compounds (100 渭L 10 mM DMSO solutions) to explore stem cell reprogramming, differentiation, proliferation and signaling</td> </tr></table></div> </div> <div class="tab_content tab_2" data-tab="2"> The <strong>Tocriscreen compound libraries</strong> are composed of biologically active compounds that have proven pharmacological activity against GPCRs, ion channels, kinases, enzymes, nuclear receptors and transporters. <ul> <li>Compounds ready-to-use in DMSO (10 mM)</li> <li>Key research areas are covered including Cancer, Epigenetics, Neuroscience and Stem Cells</li> <li>Includes commonly used standards and the latest research tools, as well pharmacologically active components of FDA-approved drug formulations</li> <li>Compounds available for re-supply from the Tocris catalog</li> </ul> <hr> <h2>Resources for Tocriscreen Compound Libraries</h2> <hr> <div class='row'> <div class='col-sm-12 col-md-6'> <h4>The Chemical Diversity of the Tocriscreen Kinase Inhibitor 3.0</h4> <p>The images show the overlapping chemical space of the 210 compounds in the Tocriscreen Kinase Inhibitor 3.0 compound library (green dots) in relation to the chemical space occupied by the ChEMBL Kinase Inhibitors (grey dots). Each dot represents a unique fingerprint generated from each compound's 3D molecular structure. The even distribution of the fingerprints of the compounds in the Tocriscreen Kinase Inhibitor 3.0 compound library highlights the chemical diversity of this library.</p> </div> <div class='col-sm-12 col-md-6 text-center'> <video width='320' height='240' controls> <source src='https://resources.tocris.com/videos/tocriscreen-kinase-gif.mp4'> </div> </div> <div class='row'> <div class='col-sm-12 col-md-6'> <h4>Webinar: Chemical Genomics - Undruggables and the Quest for Therapeutics</h4> <p>This webinar brings together experts to discuss chemical genomics and the advances and promises it brings to therapeutic discovery. The use of compound libraries and the possibilities for drug repurposing are examined, and the potential of patient lead approaches to identify novel targets with chemical genomics are considered.</p> <a href='/resources/webinars-and-videos/chemical-genomics-webinar' title='Watch the Webinar: Chemical Genomics - Undruggables and the Quest for Therapeutics' class='btn btn-quinary'>Watch Chemical Genomics Webinar</a> </div> <div class='col-sm-12 col-md-6 text-center'> <a href='/resources/webinars-and-videos/chemical-genomics-webinar' title='View Webinar : Chemical Genomics - Undruggables and the Quest for Therapeutics'><img src='https://resources.tocris.com/images/webinars/chemical-genomics-webinar.png' alt='Chemical Genomics - Undruggables and the Quest for Therapeutics'></a> </div> </div> </div> <div class="tab_content tab_3" data-tab="3"> </div> <div class="tab_content tab_4" data-tab="4"> <h3>Literature for Tocriscreen™ Compound Libraries</h3><p>Tocris offers the following scientific literature for Tocriscreen™ Compound Libraries to showcase our products. We invite you to request* your copy today!</p><p class="small">*Please note that Tocris will only send literature to established scientific business / institute addresses.</p><hr/><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/product-guides/fullsize/697383.jpg?v=2" data-toggle="lightbox" data-title="Tocriscreen Compound Libraries " data-footer="<a href='/literature/literature-request/697383' rel='nofollow' title='Request copy of the Tocriscreen Compound Libraries'>Request copy</a> or <a href='/literature/literature-request/p697383' rel='nofollow' title='Request PDF of the Tocriscreen Compound Libraries'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/product-guides/regular/697383.jpg?v=2" alt="Tocriscreen Compound Libraries " class="img-fluid"></a></div> <h4>Tocriscreen Compound Libraries </h4> <p>This brochure gives an overview of the unique Tocriscreen<sup>TM</sup> bioactive compound library range, including</p> <ul class='bullet_list'> <li>Tocriscreen 2.0 Compound Library</li> <li>Focused Tocriscreen Libraries</li> <li>Tocriscreen FDA-approved Drug Library</li> <li>Tocriscreen PRO Custom Service</li> </ul> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/697383" rel="nofollow" title="Request copy of the Tocriscreen Compound Libraries ">Request copy</a> </li><li> <a class="btn btn-quinary request-pdf" href="/literature/literature-request/p697383" rel="nofollow" title="Request PDF of the Tocriscreen Compound Libraries ">Request PDF<div class="lit_request_pdf"></div></a> </li> <li><a class="btn btn-quinary" href="/literature/product-guides" title="View all Product Guides & Listings">View all Product Guides & Listings</a></li> </ul> </div></div> </div> <div class="tab_content tab_5" data-tab="5"> </div> <div class="tab_content tab_6" data-tab="6"> </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="resources_sidebar_container"> <div class="fp_four_box"> <div class="fp_box_wrapper"><h3>Featured New Products</h3> <div class="fp_featured_product"><a href="/products/vu-0542270_8151">8151 | VU 0542270</a><br /> Selective inhibitor of K<sub>ir</sub>6.1 K<sub>ATP</sub> channels</div> <div class="fp_featured_product"><a href="/products/rna-imaging-probe-1c_8813">8813 | RNA Imaging Probe 1c</a><br /> Fluorogenic RNA imaging probe</div> <div class="fp_featured_product"><a href="/products/lsn-3318839_7959">7959 | LSN 3318839</a><br /> Glucagon-like peptide-1 receptor <br />(GLP1-R) positive allosteric modulator</div> <div class="fp_featured_product"><a href="/products/chir-99021-in-solution_8170">8170 | CHIR 99021 in solution</a><br /> Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO</div> <div class="fp_featured_product"><a href="/products/bi-3231_8039">8039 | BI 3231</a><br /> Potent and 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