CINXE.COM

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Ethos</a></li> <li class="leaf"><a href="/about-tocris/environment" id="main-menu-13876">Environment</a></li> <li class="last leaf"><a href="/about-tocris/careers-at-tocris" id="main-menu-13846">Careers</a></li> </ul></li> <li class="last leaf"><a href="/support/contact-us" id="main-menu-7501">Contact Us</a></li> </ul> </section> </div> </nav> </div> </header> <div class="breadcrumbs_wrapper"> <div class="breadcrumbs_container"> <div class="breadcrumb"><a href="/">Home</a> <span class="breadcrumb_separator">/</span> <a href="/resources">Resources</a> <span class="breadcrumb_separator">/</span> Signaling Pathways</div> </div> </div> <div class="main-container container"> <div class="row"> <section> <a id="main-content"></a> <div class="col-xs-12 col-sm-8 col-md-9"> <h1>Signaling Pathways</h1> <div class="view view-signaling-pathways view-id-signaling_pathways view-display-id-page view-dom-id-54cfcd696063b12957d3f5243d1dfb7f"> <div class="view-header"> <h2>Interactive signal transduction pathways</h2> <p>Our interactive pathways give an overview of some major signal transduction processes, and provide an alternative way to browse the Tocris website. Click on the individual proteins and receptors to locate key research tools and view the range of products Tocris has to offer.</p> </div> <div class="view-content"> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/akt-signaling-pathway">Akt Signaling Pathway</a></h3> <p><p>The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'pro-survival' pathway.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/akt-signaling-pathway" title="View Akt Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/297496.jpg" alt="Akt Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/ampk-signaling-pathway">AMPK Signaling Pathway</a></h3> <p><p>AMPK signaling pathway plays an important role in the cellular response to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/ampk-signaling-pathway" title="View AMPK Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/325798.jpg" alt="AMPK Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/apoptosis-signaling-pathway">Apoptosis Signaling Pathway</a></h3> <p><p>Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell "suicide". Apoptosis can be triggered by events both inside and outside of the cell.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/apoptosis-signaling-pathway" title="View Apoptosis Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/298869.jpg" alt="Apoptosis Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/estrogen-signaling-pathway">Estrogen Signaling Pathway</a></h3> <p><p>Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/estrogen-signaling-pathway" title="View Estrogen Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/322859.jpg" alt="Estrogen Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/insulin-signaling-pathway">Insulin Signaling Pathway</a></h3> <p><p>Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/insulin-signaling-pathway" title="View Insulin Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/298870.jpg" alt="Insulin Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/jak-stat-signaling-pathway">JAK-STAT Signaling Pathway</a></h3> <p><p>The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/jak-stat-signaling-pathway" title="View JAK-STAT Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/323445.jpg" alt="JAK-STAT Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/mapk-signaling-pathway">MAPK Signaling Pathway</a></h3> <p><p>The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/mapk-signaling-pathway" title="View MAPK Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/297495.jpg" alt="MAPK Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/mtor-signaling-pathway">mTOR Signaling Pathway</a></h3> <p><p>mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/mtor-signaling-pathway" title="View mTOR Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/304280.jpg" alt="mTOR Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/nf-kappab-signaling-pathway">NF-魏B Signaling Pathway</a></h3> <p><p>NF-魏B signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/nf-kappab-signaling-pathway" title="View NF-魏B Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/299045.jpg" alt="NF-魏B Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/notch-signaling-pathway">Notch Signaling Pathway</a></h3> <p><p>The Notch pathway is involved in determination of cell fate, regulation of pattern formation and other developmental settings. Disrupted signaling can cause developmental defects and a range of adult pathologies.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/notch-signaling-pathway" title="View Notch Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/304279.jpg" alt="Notch Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/p53-signaling-pathway">p53 Signaling Pathway</a></h3> <p><p>p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/p53-signaling-pathway" title="View p53 Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/306562.jpg" alt="p53 Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/tgf-beta-signaling-pathway">TGF-尾 Signaling Pathway</a></h3> <p><p>The TGF-尾 signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/tgf-beta-signaling-pathway" title="View TGF-尾 Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/299050.jpg" alt="TGF-尾 Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/toll-like-receptor-signaling-pathway">Toll-like Receptor Signaling Pathway</a></h3> <p><p>TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/toll-like-receptor-signaling-pathway" title="View Toll-like Receptor Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/304356.jpg" alt="Toll-like Receptor Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/vegf-signaling-pathway">VEGF Signaling Pathway</a></h3> <p><p>VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/vegf-signaling-pathway" title="View VEGF Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/302261.jpg" alt="VEGF Signaling Pathway"></a> </div> </div></span> </div> </div> <div> <div class="views-field views-field-php"> <span class="field-content"><div class="row"> <div class="col-xs-8 col-sm-9 col-md-10"> <h3><a href="/pathways/wnt-signaling-pathway">Wnt Signaling Pathway</a></h3> <p><p>The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.</p> </p> </div> <div class="col-xs-4 col-sm-3 col-md-2"> <a href="/pathways/wnt-signaling-pathway" title="View Wnt Signaling Pathway"><img src="https://resources.tocris.com/images/literature/pathways/standard/299054.jpg" alt="Wnt Signaling Pathway"></a> </div> </div></span> </div> </div> </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3"> <div class="distributor_region"></div> </div> </section> </div> </div> <footer id="footer_wrapper" class="container-fluid"> <div id="footer_wrapper_container" class="row"> <div id="footer" class="container"> <div id="footer_container" class="row"> <nav class="footer_column footer_column_1 col-xs-12 col-sm-3"> <div class="region region-footer-column-1"> <section id="block-menu-menu-corporate-menu" class="block block-menu clearfix"> <h6 class="block-title">Corporate</h6> <ul class="menu nav"><li class="first leaf"><a href="/about-tocris" id="menu-corporate-menu-14021">About Us</a></li> <li class="leaf"><a href="/about-tocris/careers-at-tocris" id="menu-corporate-menu-14026">Careers</a></li> <li class="leaf"><a href="/about-tocris/tocris-events" id="menu-corporate-menu-14031">Events</a></li> <li class="leaf"><a href="/support/terms-and-conditions-of-sale" id="menu-corporate-menu-591">Terms & Conditions</a></li> <li class="last leaf"><a href="/about-tocris/tocris-in-the-news" id="menu-corporate-menu-594">Tocris in the News</a></li> </ul> </section> </div> </nav> <nav class="footer_column footer_column_2 col-xs-12 col-sm-3"> <div class="region region-footer-column-2"> <section id="block-menu-menu-support-menu" class="block block-menu clearfix"> <h6 class="block-title">Support</h6> <ul class="menu nav"><li class="first leaf"><a href="/support/contact-us" id="menu-support-menu-603">Contact Us</a></li> <li class="leaf"><a href="/support/customer-support" id="menu-support-menu-14036">Customer Support</a></li> <li class="leaf"><a href="/distributors" id="menu-support-menu-601">Distributors</a></li> <li class="leaf"><a href="/about-tocris/licensing" id="menu-support-menu-14041">Licensing</a></li> <li class="leaf"><a href="/resources" id="menu-support-menu-14046">Scientific Resources</a></li> <li class="last leaf"><a href="/support/technical-support" id="menu-support-menu-14051">Technical Support</a></li> </ul> </section> </div> </nav> <nav class="footer_column footer_column_3 col-xs-12 col-sm-3"> <div class="region region-footer-column-3"> <section id="block-menu-menu-brands-menu" class="block block-menu clearfix"> <h6 class="block-title">Bio-Techne Brands</h6> <ul class="menu nav"><li class="first leaf"><a href="https://www.rndsystems.com/" title="" target="_blank" id="menu-brands-menu-605">R&D Systems</a></li> <li class="leaf"><a href="https://www.novusbio.com" title="" target="_blank" id="menu-brands-menu-606">Novus Biologicals</a></li> <li class="leaf"><a href="/" title="" id="menu-brands-menu-607">Tocris Bioscience</a></li> <li class="leaf"><a href="https://www.bio-techne.com/brands/proteinsimple" target="_blank" id="menu-brands-menu-608">ProteinSimple</a></li> <li class="last leaf"><a href="https://acdbio.com" title="" target="_blank" id="menu-brands-menu-9731">ACD</a></li> </ul> </section> </div> </nav> <div class="footer_column footer_column_4 col-xs-12 col-sm-3"> <div class="region region-footer-column-4"> <section id="block-block-2" class="block block-block clearfix"> <h6 class="block-title">Stay Connected</h6> <p>Get the latest news, product updates, and promotions:</p> <p><a class="btn btn-primary" href="/literature/signup" rel="nofollow">Sign Up for E-Alerts</a></p> <p>Follow Tocris:</p> <p><a class="social_link" href="https://www.linkedin.com/company/tocris-bioscience/" target="_blank" rel="nofollow"><span class="icon-linkedin-square">聽</span></a> <a class="social_link" href="https://www.facebook.com/TocrisBioscience/" target="_blank"><span class="icon-facebook-square">聽</span></a> <a class="social_link" href="https://twitter.com/Tocris" target="_blank"><span class="icon-twitter-square">聽</span></a></p> </section> </div> </div> </div> </div> </div> </footer> <div id="copyright_wrapper" class="container-fluid"> <div id="copyright_wrapper_container" class="row"> <div id="copyright" class="container"> <div id="copyright_container" class="row"> <div id="copyright_content" class="col-xs-12"> <p> <div class="region region-copyright"> <section id="block-block-4" class="block block-block clearfix"> © Copyright 2024 Tocris Bioscience. 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