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class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="41993293" href="https://www.academia.edu/Documents/in/Animals"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/HelenChristou","location":"/HelenChristou","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/HelenChristou","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Animals"]}" data-trace="false" data-dom-id="Pill-react-component-0e299492-2f4f-4382-931c-cb3d4e6568cb"></div> <div 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id="Pill-react-component-be03517e-13bd-41b6-8fc8-2d4e2dd55e73"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Helen Christou</h3></div><div class="js-work-strip profile--work_container" data-work-id="104730378"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730378/Acetazolamide_Modulates_Pulmonary_Inflammation_and_Ameliorates_Severe_Experimental_Pulmonary_Hypertension"><img alt="Research paper thumbnail of Acetazolamide Modulates Pulmonary Inflammation and Ameliorates Severe Experimental Pulmonary Hypertension" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730378/Acetazolamide_Modulates_Pulmonary_Inflammation_and_Ameliorates_Severe_Experimental_Pulmonary_Hypertension">Acetazolamide Modulates Pulmonary Inflammation and Ameliorates Severe Experimental Pulmonary Hypertension</a></div><div class="wp-workCard_item"><span>Pediatrics</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Inflammatory cytokines and several immune cells including macrophages contribute to t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Inflammatory cytokines and several immune cells including macrophages contribute to the pathobiology of Pulmonary Arterial Hypertension (PAH). Carbonic anhydrase inhibition and acidosis were reported to be involved in immune modulation, but their effects in chronic pulmonary inflammation in PAH are unknown. Objective: To evaluate whether ACTZ can ameliorate severe experimental PH. by modulating pulmonary inflammation. Design/Methods: In the Sugen 5416/hypoxia (SU/Hx) rat model of severe PH, ACTZ or ammonium chloride (NH4Cl) were administered in the drinking water. (see image for experimental timelines). We assessed right ventricular systolic pressure (RVSP), right ventricular hypertrophy (RVH as Fulton’s Index, FI) and pulmonary vascular remodeling. Expression of …</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730378"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730378"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730378; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730378]").text(description); $(".js-view-count[data-work-id=104730378]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730378; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730378']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730378, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104730378]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730378,"title":"Acetazolamide Modulates Pulmonary Inflammation and Ameliorates Severe Experimental Pulmonary Hypertension","translated_title":"","metadata":{"abstract":"Background: Inflammatory cytokines and several immune cells including macrophages contribute to the pathobiology of Pulmonary Arterial Hypertension (PAH). Carbonic anhydrase inhibition and acidosis were reported to be involved in immune modulation, but their effects in chronic pulmonary inflammation in PAH are unknown. Objective: To evaluate whether ACTZ can ameliorate severe experimental PH. by modulating pulmonary inflammation. Design/Methods: In the Sugen 5416/hypoxia (SU/Hx) rat model of severe PH, ACTZ or ammonium chloride (NH4Cl) were administered in the drinking water. (see image for experimental timelines). We assessed right ventricular systolic pressure (RVSP), right ventricular hypertrophy (RVH as Fulton’s Index, FI) and pulmonary vascular remodeling. Expression of …","publisher":"American Academy of Pediatrics (AAP)","publication_name":"Pediatrics"},"translated_abstract":"Background: Inflammatory cytokines and several immune cells including macrophages contribute to the pathobiology of Pulmonary Arterial Hypertension (PAH). Carbonic anhydrase inhibition and acidosis were reported to be involved in immune modulation, but their effects in chronic pulmonary inflammation in PAH are unknown. Objective: To evaluate whether ACTZ can ameliorate severe experimental PH. by modulating pulmonary inflammation. Design/Methods: In the Sugen 5416/hypoxia (SU/Hx) rat model of severe PH, ACTZ or ammonium chloride (NH4Cl) were administered in the drinking water. (see image for experimental timelines). We assessed right ventricular systolic pressure (RVSP), right ventricular hypertrophy (RVH as Fulton’s Index, FI) and pulmonary vascular remodeling. Expression of …","internal_url":"https://www.academia.edu/104730378/Acetazolamide_Modulates_Pulmonary_Inflammation_and_Ameliorates_Severe_Experimental_Pulmonary_Hypertension","translated_internal_url":"","created_at":"2023-07-19T08:48:24.461-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":41993293,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Acetazolamide_Modulates_Pulmonary_Inflammation_and_Ameliorates_Severe_Experimental_Pulmonary_Hypertension","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":41993293,"first_name":"Helen","middle_initials":null,"last_name":"Christou","page_name":"HelenChristou","domain_name":"independent","created_at":"2016-01-24T03:37:57.009-08:00","display_name":"Helen Christou","url":"https://independent.academia.edu/HelenChristou"},"attachments":[],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology"},{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system"},{"id":462040,"name":"Acetazolamide","url":"https://www.academia.edu/Documents/in/Acetazolamide"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3804974,"name":"right ventricular hypertrophy","url":"https://www.academia.edu/Documents/in/right_ventricular_hypertrophy"}],"urls":[{"id":32973579,"url":"https://publications.aap.org/pediatrics/article/144/2_MeetingAbstract/695/3814/Acetazolamide-Modulates-Pulmonary-Inflammation-and"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730377"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730377/Skeletal_Muscle_Dysfunction_in_Experimental_Pulmonary_Hypertension"><img alt="Research paper thumbnail of Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension" class="work-thumbnail" src="https://attachments.academia-assets.com/104381467/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730377/Skeletal_Muscle_Dysfunction_in_Experimental_Pulmonary_Hypertension">Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that is ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that is in urgent need of improved therapies that treat it. One of the remaining therapeutic challenges is the increasingly recognized skeletal muscle dysfunction that interferes with exercise tolerance. Here we report that in the adult rat Sugen/hypoxia (SU/Hx) model of severe pulmonary hypertension (PH), there is highly significant, almost 50%, decrease in exercise endurance, and this is associated with a 25% increase in the abundance of type II muscle fiber markers, thick sarcomeric aggregates and an increase in the levels of FoxO1 in the soleus (a predominantly type I fiber muscle), with additional alterations in the transcriptomic profiles of the diaphragm (a mixed fiber muscle) and the extensor digitorum longus (a predominantly Type II fiber muscle). In addition, soleus atrophy may contribute to impaired exercise endurance. Studies in L6 rat myoblasts have showed that myotube differentiati...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ecb8e288f2e080bc5a0d2751a98709fc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381467,"asset_id":104730377,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381467/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730377"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730377"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730377; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730377]").text(description); $(".js-view-count[data-work-id=104730377]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730377; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730377']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730377, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ecb8e288f2e080bc5a0d2751a98709fc" } } $('.js-work-strip[data-work-id=104730377]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730377,"title":"Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension","translated_title":"","metadata":{"abstract":"Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that is in urgent need of improved therapies that treat it. One of the remaining therapeutic challenges is the increasingly recognized skeletal muscle dysfunction that interferes with exercise tolerance. Here we report that in the adult rat Sugen/hypoxia (SU/Hx) model of severe pulmonary hypertension (PH), there is highly significant, almost 50%, decrease in exercise endurance, and this is associated with a 25% increase in the abundance of type II muscle fiber markers, thick sarcomeric aggregates and an increase in the levels of FoxO1 in the soleus (a predominantly type I fiber muscle), with additional alterations in the transcriptomic profiles of the diaphragm (a mixed fiber muscle) and the extensor digitorum longus (a predominantly Type II fiber muscle). In addition, soleus atrophy may contribute to impaired exercise endurance. Studies in L6 rat myoblasts have showed that myotube differentiati...","publisher":"MDPI AG","publication_name":"International Journal of Molecular Sciences"},"translated_abstract":"Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that is in urgent need of improved therapies that treat it. One of the remaining therapeutic challenges is the increasingly recognized skeletal muscle dysfunction that interferes with exercise tolerance. Here we report that in the adult rat Sugen/hypoxia (SU/Hx) model of severe pulmonary hypertension (PH), there is highly significant, almost 50%, decrease in exercise endurance, and this is associated with a 25% increase in the abundance of type II muscle fiber markers, thick sarcomeric aggregates and an increase in the levels of FoxO1 in the soleus (a predominantly type I fiber muscle), with additional alterations in the transcriptomic profiles of the diaphragm (a mixed fiber muscle) and the extensor digitorum longus (a predominantly Type II fiber muscle). In addition, soleus atrophy may contribute to impaired exercise endurance. Studies in L6 rat myoblasts have showed that myotube differentiati...","internal_url":"https://www.academia.edu/104730377/Skeletal_Muscle_Dysfunction_in_Experimental_Pulmonary_Hypertension","translated_internal_url":"","created_at":"2023-07-19T08:48:24.275-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":41993293,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":104381467,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381467/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/104381467/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Skeletal_Muscle_Dysfunction_in_Experimen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381467/pdf-libre.pdf?1689782519=\u0026response-content-disposition=attachment%3B+filename%3DSkeletal_Muscle_Dysfunction_in_Experimen.pdf\u0026Expires=1732412926\u0026Signature=N-C0HN2VFHvKp1i0yzTOCmX40d4Yh9MOWXINOUqorPvNvM80SJmbjkjNkppf24eaBMyyMsQy4lXou~845ScnAOzR36q0iU5L-62kpSIo3Hanlih46pwUcbpLgsevnHHeEQ38URRCO-QnEZr~yrIQVXaJeJiBe9BBG1f-kCr4GdG5XkK2qjoEUyXFWH4FhsJd5S6rzf5WXfoocO1p8BqVTHljLVct7Z9WKER3WDjz~AsX5sxV~pWpMCRs3n4Gkv6GYZFzKKjkPMQ48M1FaR~fxCLnaSAhbaVPIO4sc2YIGLc2ubkb8dnAkbGMWPGSjxk~FNrExdJFWrPgSJX8iUsYNQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Skeletal_Muscle_Dysfunction_in_Experimental_Pulmonary_Hypertension","translated_slug":"","page_count":21,"language":"en","content_type":"Work","owner":{"id":41993293,"first_name":"Helen","middle_initials":null,"last_name":"Christou","page_name":"HelenChristou","domain_name":"independent","created_at":"2016-01-24T03:37:57.009-08:00","display_name":"Helen Christou","url":"https://independent.academia.edu/HelenChristou"},"attachments":[{"id":104381467,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381467/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/104381467/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Skeletal_Muscle_Dysfunction_in_Experimen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381467/pdf-libre.pdf?1689782519=\u0026response-content-disposition=attachment%3B+filename%3DSkeletal_Muscle_Dysfunction_in_Experimen.pdf\u0026Expires=1732412926\u0026Signature=N-C0HN2VFHvKp1i0yzTOCmX40d4Yh9MOWXINOUqorPvNvM80SJmbjkjNkppf24eaBMyyMsQy4lXou~845ScnAOzR36q0iU5L-62kpSIo3Hanlih46pwUcbpLgsevnHHeEQ38URRCO-QnEZr~yrIQVXaJeJiBe9BBG1f-kCr4GdG5XkK2qjoEUyXFWH4FhsJd5S6rzf5WXfoocO1p8BqVTHljLVct7Z9WKER3WDjz~AsX5sxV~pWpMCRs3n4Gkv6GYZFzKKjkPMQ48M1FaR~fxCLnaSAhbaVPIO4sc2YIGLc2ubkb8dnAkbGMWPGSjxk~FNrExdJFWrPgSJX8iUsYNQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":276821,"name":"Molecular sciences","url":"https://www.academia.edu/Documents/in/Molecular_sciences"},{"id":357849,"name":"Skeletal Muscle","url":"https://www.academia.edu/Documents/in/Skeletal_Muscle"},{"id":585049,"name":"Myocyte","url":"https://www.academia.edu/Documents/in/Myocyte"},{"id":2807671,"name":"Soleus muscle","url":"https://www.academia.edu/Documents/in/Soleus_muscle"}],"urls":[{"id":32973578,"url":"https://www.mdpi.com/1422-0067/23/18/10912/pdf"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730375"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730375/Adipokines_and_Metabolic_Regulators_in_Human_and_Experimental_Pulmonary_Arterial_Hypertension"><img alt="Research paper thumbnail of Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension" class="work-thumbnail" src="https://attachments.academia-assets.com/104381466/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730375/Adipokines_and_Metabolic_Regulators_in_Human_and_Experimental_Pulmonary_Arterial_Hypertension">Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pulmonary hypertension (PH) is associated with meta-inflammation related to obesity but the role ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pulmonary hypertension (PH) is associated with meta-inflammation related to obesity but the role of adipose tissue in PH pathogenesis is unknown. We hypothesized that adipose tissue-derived metabolic regulators are altered in human and experimental PH. We measured circulating levels of fatty acid binding protein 4 (FABP-4), fibroblast growth factor -21 (FGF-21), adiponectin, and the mRNA levels of FABP-4, FGF-21, and peroxisome proliferator-activated receptor γ (PPARγ) in lung tissue of patients with idiopathic PH and healthy controls. We also evaluated lung and adipose tissue expression of these mediators in the three most commonly used experimental rodent models of pulmonary hypertension. Circulating levels of FABP-4, FGF-21, and adiponectin were significantly elevated in PH patients compared to controls and the mRNA levels of these regulators and PPARγ were also significantly increased in human PH lungs and in the lungs of rats with experimental PH compared to controls. These fin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9a63c9ecf199fbe2f8aded1654f7c4b2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381466,"asset_id":104730375,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381466/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730375"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730375"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730375; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730375]").text(description); $(".js-view-count[data-work-id=104730375]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730375; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730375']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730375, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9a63c9ecf199fbe2f8aded1654f7c4b2" } } $('.js-work-strip[data-work-id=104730375]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730375,"title":"Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension","translated_title":"","metadata":{"abstract":"Pulmonary hypertension (PH) is associated with meta-inflammation related to obesity but the role of adipose tissue in PH pathogenesis is unknown. We hypothesized that adipose tissue-derived metabolic regulators are altered in human and experimental PH. We measured circulating levels of fatty acid binding protein 4 (FABP-4), fibroblast growth factor -21 (FGF-21), adiponectin, and the mRNA levels of FABP-4, FGF-21, and peroxisome proliferator-activated receptor γ (PPARγ) in lung tissue of patients with idiopathic PH and healthy controls. We also evaluated lung and adipose tissue expression of these mediators in the three most commonly used experimental rodent models of pulmonary hypertension. Circulating levels of FABP-4, FGF-21, and adiponectin were significantly elevated in PH patients compared to controls and the mRNA levels of these regulators and PPARγ were also significantly increased in human PH lungs and in the lungs of rats with experimental PH compared to controls. These fin...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"International Journal of Molecular Sciences"},"translated_abstract":"Pulmonary hypertension (PH) is associated with meta-inflammation related to obesity but the role of adipose tissue in PH pathogenesis is unknown. We hypothesized that adipose tissue-derived metabolic regulators are altered in human and experimental PH. We measured circulating levels of fatty acid binding protein 4 (FABP-4), fibroblast growth factor -21 (FGF-21), adiponectin, and the mRNA levels of FABP-4, FGF-21, and peroxisome proliferator-activated receptor γ (PPARγ) in lung tissue of patients with idiopathic PH and healthy controls. We also evaluated lung and adipose tissue expression of these mediators in the three most commonly used experimental rodent models of pulmonary hypertension. Circulating levels of FABP-4, FGF-21, and adiponectin were significantly elevated in PH patients compared to controls and the mRNA levels of these regulators and PPARγ were also significantly increased in human PH lungs and in the lungs of rats with experimental PH compared to controls. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730370"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730370/Acetazolamide_Improves_Right_Ventricular_Function_and_Metabolic_Gene_Dysregulation_in_Experimental_Pulmonary_Arterial_Hypertension"><img alt="Research paper thumbnail of Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension" class="work-thumbnail" src="https://attachments.academia-assets.com/104381495/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730370/Acetazolamide_Improves_Right_Ventricular_Function_and_Metabolic_Gene_Dysregulation_in_Experimental_Pulmonary_Arterial_Hypertension">Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension</a></div><div class="wp-workCard_item"><span>Frontiers in Cardiovascular Medicine</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Right ventricular (RV) performance is a key determinant of mortality in pulmonary art...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Right ventricular (RV) performance is a key determinant of mortality in pulmonary arterial hypertension (PAH). RV failure is characterized by metabolic dysregulation with unbalanced anaerobic glycolysis, oxidative phosphorylation, and fatty acid oxidation (FAO). We previously found that acetazolamide (ACTZ) treatment modulates the pulmonary inflammatory response and ameliorates experimental PAH.Objective: To evaluate the effect of ACTZ treatment on RV function and metabolic profile in experimental PAH.Design/Methods: In the Sugen 5416/hypoxia (SuHx) rat model of severe PAH, RV transcriptomic analysis was performed by RNA-seq, and top metabolic targets were validated by RT-PCR. We assessed the effect of therapeutic administration of ACTZ in the drinking water on hemodynamics by catheterization [right and left ventricular systolic pressure (RVSP and LVSP, respectively)] and echocardiography [pulmonary artery acceleration time (PAAT), RV wall thickness in diastole (RVWT), R...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="04fa5ab9f5795103f4a622d27206d691" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381495,"asset_id":104730370,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381495/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730370"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730370"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730370; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730370]").text(description); $(".js-view-count[data-work-id=104730370]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730370; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730370']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730370, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "04fa5ab9f5795103f4a622d27206d691" } } $('.js-work-strip[data-work-id=104730370]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730370,"title":"Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension","translated_title":"","metadata":{"abstract":"Background: Right ventricular (RV) performance is a key determinant of mortality in pulmonary arterial hypertension (PAH). RV failure is characterized by metabolic dysregulation with unbalanced anaerobic glycolysis, oxidative phosphorylation, and fatty acid oxidation (FAO). We previously found that acetazolamide (ACTZ) treatment modulates the pulmonary inflammatory response and ameliorates experimental PAH.Objective: To evaluate the effect of ACTZ treatment on RV function and metabolic profile in experimental PAH.Design/Methods: In the Sugen 5416/hypoxia (SuHx) rat model of severe PAH, RV transcriptomic analysis was performed by RNA-seq, and top metabolic targets were validated by RT-PCR. We assessed the effect of therapeutic administration of ACTZ in the drinking water on hemodynamics by catheterization [right and left ventricular systolic pressure (RVSP and LVSP, respectively)] and echocardiography [pulmonary artery acceleration time (PAAT), RV wall thickness in diastole (RVWT), R...","publisher":"Frontiers Media SA","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Frontiers in Cardiovascular Medicine"},"translated_abstract":"Background: Right ventricular (RV) performance is a key determinant of mortality in pulmonary arterial hypertension (PAH). RV failure is characterized by metabolic dysregulation with unbalanced anaerobic glycolysis, oxidative phosphorylation, and fatty acid oxidation (FAO). We previously found that acetazolamide (ACTZ) treatment modulates the pulmonary inflammatory response and ameliorates experimental PAH.Objective: To evaluate the effect of ACTZ treatment on RV function and metabolic profile in experimental PAH.Design/Methods: In the Sugen 5416/hypoxia (SuHx) rat model of severe PAH, RV transcriptomic analysis was performed by RNA-seq, and top metabolic targets were validated by RT-PCR. We assessed the effect of therapeutic administration of ACTZ in the drinking water on hemodynamics by catheterization [right and left ventricular systolic pressure (RVSP and LVSP, respectively)] and echocardiography [pulmonary artery acceleration time (PAAT), RV wall thickness in diastole (RVWT), R...","internal_url":"https://www.academia.edu/104730370/Acetazolamide_Improves_Right_Ventricular_Function_and_Metabolic_Gene_Dysregulation_in_Experimental_Pulmonary_Arterial_Hypertension","translated_internal_url":"","created_at":"2023-07-19T08:48:23.014-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":41993293,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":104381495,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381495/thumbnails/1.jpg","file_name":"fcvm-08-662870.pdf","download_url":"https://www.academia.edu/attachments/104381495/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acetazolamide_Improves_Right_Ventricular.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381495/fcvm-08-662870-libre.pdf?1689782481=\u0026response-content-disposition=attachment%3B+filename%3DAcetazolamide_Improves_Right_Ventricular.pdf\u0026Expires=1732412926\u0026Signature=IcXem9TF8FOYQYVXql9NP6PKVNpTzMHa3Y-TtxJUGWxZ58K4d6QlJW~hBjc4ZHuOy8FKCtbpzhv2R6wKLW5Ky9Cg7jQk3MbapsQg7-SBr9A3BNOosEhe10j4b98gTlxc4dumeXEi0SCmfQW2Dr5oIs0BdbT1XlVG4-JbTEll0EA4tlLcKERq58MojxJGU5iBCUJY9CJcmMI~3sYWTmkYG8US9jgrtfaaIQ1Xrye1t6o0Q2kB7cN5uF9SE0fkUNhxHp0rEimjMrPCp9O6dvuBA06ibHqCo7NBw6KkFDfv74HVTY59Tkr-MwKWUaRXGQzGjNc-cjQUGC8xukD2mNUZcw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Acetazolamide_Improves_Right_Ventricular_Function_and_Metabolic_Gene_Dysregulation_in_Experimental_Pulmonary_Arterial_Hypertension","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":41993293,"first_name":"Helen","middle_initials":null,"last_name":"Christou","page_name":"HelenChristou","domain_name":"independent","created_at":"2016-01-24T03:37:57.009-08:00","display_name":"Helen Christou","url":"https://independent.academia.edu/HelenChristou"},"attachments":[{"id":104381495,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381495/thumbnails/1.jpg","file_name":"fcvm-08-662870.pdf","download_url":"https://www.academia.edu/attachments/104381495/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acetazolamide_Improves_Right_Ventricular.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381495/fcvm-08-662870-libre.pdf?1689782481=\u0026response-content-disposition=attachment%3B+filename%3DAcetazolamide_Improves_Right_Ventricular.pdf\u0026Expires=1732412926\u0026Signature=IcXem9TF8FOYQYVXql9NP6PKVNpTzMHa3Y-TtxJUGWxZ58K4d6QlJW~hBjc4ZHuOy8FKCtbpzhv2R6wKLW5Ky9Cg7jQk3MbapsQg7-SBr9A3BNOosEhe10j4b98gTlxc4dumeXEi0SCmfQW2Dr5oIs0BdbT1XlVG4-JbTEll0EA4tlLcKERq58MojxJGU5iBCUJY9CJcmMI~3sYWTmkYG8US9jgrtfaaIQ1Xrye1t6o0Q2kB7cN5uF9SE0fkUNhxHp0rEimjMrPCp9O6dvuBA06ibHqCo7NBw6KkFDfv74HVTY59Tkr-MwKWUaRXGQzGjNc-cjQUGC8xukD2mNUZcw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":2369445,"name":"Pulmonary Artery","url":"https://www.academia.edu/Documents/in/Pulmonary_Artery"},{"id":4238921,"name":"beta oxidation","url":"https://www.academia.edu/Documents/in/beta_oxidation"}],"urls":[{"id":32973573,"url":"https://www.frontiersin.org/articles/10.3389/fcvm.2021.662870/full"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730369"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730369/Metabolomic_and_transcriptomic_signatures_of_prenatal_excessive_methionine_support_nature_rather_than_nurture_in_schizophrenia_pathogenesis"><img alt="Research paper thumbnail of Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis" class="work-thumbnail" src="https://attachments.academia-assets.com/104381464/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730369/Metabolomic_and_transcriptomic_signatures_of_prenatal_excessive_methionine_support_nature_rather_than_nurture_in_schizophrenia_pathogenesis">Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis</a></div><div class="wp-workCard_item"><span>Communications Biology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The imbalance of prenatal micronutrients may perturb one-carbon (C1) metabolism and increase the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The imbalance of prenatal micronutrients may perturb one-carbon (C1) metabolism and increase the risk for neuropsychiatric disorders. Prenatal excessive methionine (MET) produces in mice behavioral phenotypes reminiscent of human schizophrenia. Whether in-utero programming or early life caregiving mediate these effects is, however, unknown. Here, we show that the behavioral deficits of MET are independent of the early life mother-infant interaction. We also show that MET produces in early life profound changes in the brain C1 pathway components as well as glutamate transmission, mitochondrial function, and lipid metabolism. Bioinformatics analysis integrating metabolomics and transcriptomic data reveal dysregulations of glutamate transmission and lipid metabolism, and identify perturbed pathways of methylation and redox reactions. Our transcriptomics Linkage analysis of MET mice and schizophrenia subjects reveals master genes involved in inflammation and myelination. Finally, we ide...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="19ef782d3c95e00de4c452729bf8c313" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381464,"asset_id":104730369,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381464/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730369"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730369"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730369; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730369]").text(description); $(".js-view-count[data-work-id=104730369]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730369; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730369']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730369, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "19ef782d3c95e00de4c452729bf8c313" } } $('.js-work-strip[data-work-id=104730369]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730369,"title":"Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis","translated_title":"","metadata":{"abstract":"The imbalance of prenatal micronutrients may perturb one-carbon (C1) metabolism and increase the risk for neuropsychiatric disorders. Prenatal excessive methionine (MET) produces in mice behavioral phenotypes reminiscent of human schizophrenia. Whether in-utero programming or early life caregiving mediate these effects is, however, unknown. Here, we show that the behavioral deficits of MET are independent of the early life mother-infant interaction. We also show that MET produces in early life profound changes in the brain C1 pathway components as well as glutamate transmission, mitochondrial function, and lipid metabolism. Bioinformatics analysis integrating metabolomics and transcriptomic data reveal dysregulations of glutamate transmission and lipid metabolism, and identify perturbed pathways of methylation and redox reactions. Our transcriptomics Linkage analysis of MET mice and schizophrenia subjects reveals master genes involved in inflammation and myelination. Finally, we ide...","publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Communications Biology"},"translated_abstract":"The imbalance of prenatal micronutrients may perturb one-carbon (C1) metabolism and increase the risk for neuropsychiatric disorders. Prenatal excessive methionine (MET) produces in mice behavioral phenotypes reminiscent of human schizophrenia. Whether in-utero programming or early life caregiving mediate these effects is, however, unknown. Here, we show that the behavioral deficits of MET are independent of the early life mother-infant interaction. We also show that MET produces in early life profound changes in the brain C1 pathway components as well as glutamate transmission, mitochondrial function, and lipid metabolism. Bioinformatics analysis integrating metabolomics and transcriptomic data reveal dysregulations of glutamate transmission and lipid metabolism, and identify perturbed pathways of methylation and redox reactions. Our transcriptomics Linkage analysis of MET mice and schizophrenia subjects reveals master genes involved in inflammation and myelination. Finally, we ide...","internal_url":"https://www.academia.edu/104730369/Metabolomic_and_transcriptomic_signatures_of_prenatal_excessive_methionine_support_nature_rather_than_nurture_in_schizophrenia_pathogenesis","translated_internal_url":"","created_at":"2023-07-19T08:48:22.797-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":41993293,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":104381464,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381464/thumbnails/1.jpg","file_name":"s42003-020-01124-8.pdf","download_url":"https://www.academia.edu/attachments/104381464/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Metabolomic_and_transcriptomic_signature.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381464/s42003-020-01124-8-libre.pdf?1689782500=\u0026response-content-disposition=attachment%3B+filename%3DMetabolomic_and_transcriptomic_signature.pdf\u0026Expires=1732412926\u0026Signature=HE6X6lLtkUXQGdw~4rH-HAVg~J1mtvZ4k1giwqj6XAHX1krO8JIIoimIuxmdsifc4765Clr30x4I5hM7wKXWTKZ-5vWQJyktKQiTz6kYSzrO0BT6GFnHcx29jOK9Pisizc94mjeWkxIsjI0KjR0nEhF06sXg7fFaFf5syH23RyVwkmG0a8-8N5VMlS-Of8lPTMd0HXiZbgoZ0zAIGtBfcNHuxf65LcizeFdXKcdACPPD1NgLybRAYI~0ptR5RwM59Smib5tYS-pVKRkKwop7fhAcniiwg6AHgMh5Z0DNpsQ3QCIKrQinX1Wo2icy3w1Y7aWHG6-woFi5URnCKoRLRA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Metabolomic_and_transcriptomic_signatures_of_prenatal_excessive_methionine_support_nature_rather_than_nurture_in_schizophrenia_pathogenesis","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":41993293,"first_name":"Helen","middle_initials":null,"last_name":"Christou","page_name":"HelenChristou","domain_name":"independent","created_at":"2016-01-24T03:37:57.009-08:00","display_name":"Helen Christou","url":"https://independent.academia.edu/HelenChristou"},"attachments":[{"id":104381464,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381464/thumbnails/1.jpg","file_name":"s42003-020-01124-8.pdf","download_url":"https://www.academia.edu/attachments/104381464/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Metabolomic_and_transcriptomic_signature.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381464/s42003-020-01124-8-libre.pdf?1689782500=\u0026response-content-disposition=attachment%3B+filename%3DMetabolomic_and_transcriptomic_signature.pdf\u0026Expires=1732412926\u0026Signature=HE6X6lLtkUXQGdw~4rH-HAVg~J1mtvZ4k1giwqj6XAHX1krO8JIIoimIuxmdsifc4765Clr30x4I5hM7wKXWTKZ-5vWQJyktKQiTz6kYSzrO0BT6GFnHcx29jOK9Pisizc94mjeWkxIsjI0KjR0nEhF06sXg7fFaFf5syH23RyVwkmG0a8-8N5VMlS-Of8lPTMd0HXiZbgoZ0zAIGtBfcNHuxf65LcizeFdXKcdACPPD1NgLybRAYI~0ptR5RwM59Smib5tYS-pVKRkKwop7fhAcniiwg6AHgMh5Z0DNpsQ3QCIKrQinX1Wo2icy3w1Y7aWHG6-woFi5URnCKoRLRA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":7802,"name":"Metabolomics","url":"https://www.academia.edu/Documents/in/Metabolomics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":43761,"name":"Transcriptome","url":"https://www.academia.edu/Documents/in/Transcriptome"},{"id":3878940,"name":"Communications biology","url":"https://www.academia.edu/Documents/in/Communications_biology"}],"urls":[{"id":32973572,"url":"https://www.nature.com/articles/s42003-020-01124-8.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730368"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730368/Echocardiographic_markers_of_pulmonary_hemodynamics_and_right_ventricular_hypertrophy_in_rat_models_of_pulmonary_hypertension"><img alt="Research paper thumbnail of Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension" class="work-thumbnail" src="https://attachments.academia-assets.com/104381487/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730368/Echocardiographic_markers_of_pulmonary_hemodynamics_and_right_ventricular_hypertrophy_in_rat_models_of_pulmonary_hypertension">Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension</a></div><div class="wp-workCard_item"><span>Pulmonary Circulation</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Echocardiography is the gold standard non-invasive technique to diagnose pulmonary hypertension. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Echocardiography is the gold standard non-invasive technique to diagnose pulmonary hypertension. It is also an important modality used to monitor disease progression and response to treatment in patients with pulmonary hypertension. Surprisingly, only few studies have been conducted to validate and standardize echocardiographic parameters in experimental animal models of pulmonary hypertension. We sought to define cut-off values for both invasive and non-invasive measures of pulmonary hemodynamics and right ventricular hypertrophy that would reliably diagnose pulmonary hypertension in three different rat models. The study was designed in two phases: (1) a derivation phase to establish the cut-off values for invasive measures of right ventricular systolic pressure, Fulton&#39;s index (right ventricular weight/left ventricle + septum weight), right ventricular to body weight ratio, and non-invasive echocardiographic measures of pulmonary arterial acceleration time, pulmonary arterial ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bc8b86af036b71a92b5816c8828002e5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381487,"asset_id":104730368,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381487/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730368"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730368"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730368; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730368]").text(description); $(".js-view-count[data-work-id=104730368]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730368; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730368']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730368, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bc8b86af036b71a92b5816c8828002e5" } } $('.js-work-strip[data-work-id=104730368]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730368,"title":"Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension","translated_title":"","metadata":{"abstract":"Echocardiography is the gold standard non-invasive technique to diagnose pulmonary hypertension. It is also an important modality used to monitor disease progression and response to treatment in patients with pulmonary hypertension. Surprisingly, only few studies have been conducted to validate and standardize echocardiographic parameters in experimental animal models of pulmonary hypertension. We sought to define cut-off values for both invasive and non-invasive measures of pulmonary hemodynamics and right ventricular hypertrophy that would reliably diagnose pulmonary hypertension in three different rat models. The study was designed in two phases: (1) a derivation phase to establish the cut-off values for invasive measures of right ventricular systolic pressure, Fulton\u0026#39;s index (right ventricular weight/left ventricle + septum weight), right ventricular to body weight ratio, and non-invasive echocardiographic measures of pulmonary arterial acceleration time, pulmonary arterial ...","publisher":"Wiley","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Pulmonary Circulation"},"translated_abstract":"Echocardiography is the gold standard non-invasive technique to diagnose pulmonary hypertension. It is also an important modality used to monitor disease progression and response to treatment in patients with pulmonary hypertension. Surprisingly, only few studies have been conducted to validate and standardize echocardiographic parameters in experimental animal models of pulmonary hypertension. We sought to define cut-off values for both invasive and non-invasive measures of pulmonary hemodynamics and right ventricular hypertrophy that would reliably diagnose pulmonary hypertension in three different rat models. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730366"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730366/Control_of_Human_Hemoglobin_Switching_By_LIN28B_Mediated_Regulation_of_BCL11A_Translation"><img alt="Research paper thumbnail of Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation" class="work-thumbnail" src="https://attachments.academia-assets.com/104381486/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730366/Control_of_Human_Hemoglobin_Switching_By_LIN28B_Mediated_Regulation_of_BCL11A_Translation">Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation</a></div><div class="wp-workCard_item"><span>Blood</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Both sickle cell disease and β-thalassemia are major sources of morbidity and mortality worldwide...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Both sickle cell disease and β-thalassemia are major sources of morbidity and mortality worldwide. Continued production of the β-like γ-globin genes that form fetal hemoglobin after infancy has been shown to ameliorate the severity of these disorders. As a result, there has been considerable interest in understanding the underlying regulation of the physiologic fetal-to-adult hemoglobin switch in humans to be able to better manipulate this process for therapeutic purposes. To date, only a single factor, BCL11A, has been identified as being involved in the developmental regulation of human hemoglobin switching. BCL11A is a direct transcriptional repressor of the γ-globin genes. Moreover, BCL11A is expressed in a developmental stage-specific manner to regulate human hemoglobin switching. However, despite extensive studies, the mechanisms that act upstream to regulate BCL11A expression and thereby control hemoglobin switching have remained elusive. To gain further insights, we have dir...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="295e8d6029407e7d9e958581b9ea6d73" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381486,"asset_id":104730366,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381486/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730366"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730366"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730366; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730366]").text(description); $(".js-view-count[data-work-id=104730366]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730366; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730366']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730366, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "295e8d6029407e7d9e958581b9ea6d73" } } $('.js-work-strip[data-work-id=104730366]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730366,"title":"Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation","translated_title":"","metadata":{"abstract":"Both sickle cell disease and β-thalassemia are major sources of morbidity and mortality worldwide. Continued production of the β-like γ-globin genes that form fetal hemoglobin after infancy has been shown to ameliorate the severity of these disorders. As a result, there has been considerable interest in understanding the underlying regulation of the physiologic fetal-to-adult hemoglobin switch in humans to be able to better manipulate this process for therapeutic purposes. To date, only a single factor, BCL11A, has been identified as being involved in the developmental regulation of human hemoglobin switching. BCL11A is a direct transcriptional repressor of the γ-globin genes. Moreover, BCL11A is expressed in a developmental stage-specific manner to regulate human hemoglobin switching. However, despite extensive studies, the mechanisms that act upstream to regulate BCL11A expression and thereby control hemoglobin switching have remained elusive. To gain further insights, we have dir...","publisher":"American Society of Hematology","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Blood"},"translated_abstract":"Both sickle cell disease and β-thalassemia are major sources of morbidity and mortality worldwide. Continued production of the β-like γ-globin genes that form fetal hemoglobin after infancy has been shown to ameliorate the severity of these disorders. As a result, there has been considerable interest in understanding the underlying regulation of the physiologic fetal-to-adult hemoglobin switch in humans to be able to better manipulate this process for therapeutic purposes. To date, only a single factor, BCL11A, has been identified as being involved in the developmental regulation of human hemoglobin switching. BCL11A is a direct transcriptional repressor of the γ-globin genes. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730364"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730364/Macrophage_FABP4_is_required_for_neutrophil_recruitment_and_bacterial_clearance_in_Pseudomonas_aeruginosa_pneumonia"><img alt="Research paper thumbnail of Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia" class="work-thumbnail" src="https://attachments.academia-assets.com/104381494/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730364/Macrophage_FABP4_is_required_for_neutrophil_recruitment_and_bacterial_clearance_in_Pseudomonas_aeruginosa_pneumonia">Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia</a></div><div class="wp-workCard_item"><span>FASEB journal : official publication of the Federation of American Societies for Experimental Biology</span><span>, Jan 21, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fatty acid binding protein 4 (FABP4), an intracellular lipid chaperone and adipokine, is expresse...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fatty acid binding protein 4 (FABP4), an intracellular lipid chaperone and adipokine, is expressed by lung macrophages, but the function of macrophage-FABP4 remains elusive. We investigated the role of FABP4 in host defense in a murine model of Pseudomonas aeruginosa pneumonia. Compared with wild-type (WT) mice, FABP4-deficient (FABP4) mice exhibited decreased bacterial clearance and increased mortality when challenged intranasally with P. aeruginosa. These findings in FABP4 mice were associated with a delayed neutrophil recruitment into the lungs and were followed by greater acute lung injury and inflammation. Among leukocytes, only macrophages expressed FABP4 in WT mice with P. aeruginosa pneumonia. Chimeric FABP4 mice with WT bone marrow were protected from increased mortality seen in chimeric WT mice with FABP4 bone marrow during P. aeruginosa pneumonia, thus confirming the role of macrophages as the main source of protective FABP4 against that infection. There was less producti...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3241b1183891b4bd0e74977b25434925" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381494,"asset_id":104730364,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381494/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730364"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730364"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730364; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730364]").text(description); $(".js-view-count[data-work-id=104730364]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730364; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730364']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730364, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3241b1183891b4bd0e74977b25434925" } } $('.js-work-strip[data-work-id=104730364]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730364,"title":"Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia","translated_title":"","metadata":{"abstract":"Fatty acid binding protein 4 (FABP4), an intracellular lipid chaperone and adipokine, is expressed by lung macrophages, but the function of macrophage-FABP4 remains elusive. We investigated the role of FABP4 in host defense in a murine model of Pseudomonas aeruginosa pneumonia. Compared with wild-type (WT) mice, FABP4-deficient (FABP4) mice exhibited decreased bacterial clearance and increased mortality when challenged intranasally with P. aeruginosa. These findings in FABP4 mice were associated with a delayed neutrophil recruitment into the lungs and were followed by greater acute lung injury and inflammation. Among leukocytes, only macrophages expressed FABP4 in WT mice with P. aeruginosa pneumonia. Chimeric FABP4 mice with WT bone marrow were protected from increased mortality seen in chimeric WT mice with FABP4 bone marrow during P. aeruginosa pneumonia, thus confirming the role of macrophages as the main source of protective FABP4 against that infection. There was less producti...","publication_date":{"day":21,"month":1,"year":2018,"errors":{}},"publication_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},"translated_abstract":"Fatty acid binding protein 4 (FABP4), an intracellular lipid chaperone and adipokine, is expressed by lung macrophages, but the function of macrophage-FABP4 remains elusive. We investigated the role of FABP4 in host defense in a murine model of Pseudomonas aeruginosa pneumonia. Compared with wild-type (WT) mice, FABP4-deficient (FABP4) mice exhibited decreased bacterial clearance and increased mortality when challenged intranasally with P. aeruginosa. These findings in FABP4 mice were associated with a delayed neutrophil recruitment into the lungs and were followed by greater acute lung injury and inflammation. Among leukocytes, only macrophages expressed FABP4 in WT mice with P. aeruginosa pneumonia. Chimeric FABP4 mice with WT bone marrow were protected from increased mortality seen in chimeric WT mice with FABP4 bone marrow during P. aeruginosa pneumonia, thus confirming the role of macrophages as the main source of protective FABP4 against that infection. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730363"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730363/Bronchopulmonary_Dysplasia_An_Update_of_Current_Pharmacologic_Therapies_and_New_Approaches"><img alt="Research paper thumbnail of Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches" class="work-thumbnail" src="https://attachments.academia-assets.com/104381461/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730363/Bronchopulmonary_Dysplasia_An_Update_of_Current_Pharmacologic_Therapies_and_New_Approaches">Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches</a></div><div class="wp-workCard_item"><span>Clinical Medicine Insights: Pediatrics</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of surviving extr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of surviving extremely preterm infants and is associated with significant health care utilization in infancy and beyond. Recent advances in neonatal care have resulted in improved survival of extremely low birth weight (ELBW) infants; however, the incidence of BPD has not been substantially impacted by novel interventions in this vulnerable population. The multifactorial cause of BPD requires a multi-pronged approach for prevention and treatment. New approaches in assisted ventilation, optimal nutrition, and pharmacologic interventions are currently being evaluated. The focus of this review is the current state of the evidence for pharmacotherapy in BPD. Promising future approaches in need of further study will also be reviewed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c96d1fc02534d18d64ddaa0b812d676f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381461,"asset_id":104730363,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381461/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730363"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730363"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730363; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730363]").text(description); $(".js-view-count[data-work-id=104730363]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730363; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730363']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730363, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c96d1fc02534d18d64ddaa0b812d676f" } } $('.js-work-strip[data-work-id=104730363]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730363,"title":"Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches","translated_title":"","metadata":{"abstract":"Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of surviving extremely preterm infants and is associated with significant health care utilization in infancy and beyond. Recent advances in neonatal care have resulted in improved survival of extremely low birth weight (ELBW) infants; however, the incidence of BPD has not been substantially impacted by novel interventions in this vulnerable population. The multifactorial cause of BPD requires a multi-pronged approach for prevention and treatment. New approaches in assisted ventilation, optimal nutrition, and pharmacologic interventions are currently being evaluated. The focus of this review is the current state of the evidence for pharmacotherapy in BPD. Promising future approaches in need of further study will also be reviewed.","publisher":"SAGE Publications","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Clinical Medicine Insights: Pediatrics"},"translated_abstract":"Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of surviving extremely preterm infants and is associated with significant health care utilization in infancy and beyond. Recent advances in neonatal care have resulted in improved survival of extremely low birth weight (ELBW) infants; however, the incidence of BPD has not been substantially impacted by novel interventions in this vulnerable population. The multifactorial cause of BPD requires a multi-pronged approach for prevention and treatment. New approaches in assisted ventilation, optimal nutrition, and pharmacologic interventions are currently being evaluated. The focus of this review is the current state of the evidence for pharmacotherapy in BPD. Promising future approaches in need of further study will also be reviewed.","internal_url":"https://www.academia.edu/104730363/Bronchopulmonary_Dysplasia_An_Update_of_Current_Pharmacologic_Therapies_and_New_Approaches","translated_internal_url":"","created_at":"2023-07-19T08:48:21.691-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":41993293,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":104381461,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381461/thumbnails/1.jpg","file_name":"1179556518817322.pdf","download_url":"https://www.academia.edu/attachments/104381461/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bronchopulmonary_Dysplasia_An_Update_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381461/1179556518817322-libre.pdf?1689782496=\u0026response-content-disposition=attachment%3B+filename%3DBronchopulmonary_Dysplasia_An_Update_of.pdf\u0026Expires=1732412926\u0026Signature=BUVhFh080F0wOzhcey9mtq5JkhHaT4XCZqhXxUtRS7RBhONCDq6G91AdNl25mpVYlvwLBeO23sTw-SKE2Cnl8O3Ypr7dY7w~5-U~IKzHT~805gdkniXXof3fTneCHvwf26hf3N7OPGXG5pY3CiuevVy5S74cSuqoh8~-QQnnryZCwvXnGIT4HwieCTUuKOymbpb1RYtOUh1LWogWNg7dGFSCmaK9Du11OAjeHHi-IuWLkNQx4cqo1Y7gqnqLT349zOXrK~1zypsk1nd3fULjYScOXHujhhffXOiUFK74xr5xYuDQBdGtL5gzimY8QCJDUsbR3vSacwXRESY8OqjBEA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Bronchopulmonary_Dysplasia_An_Update_of_Current_Pharmacologic_Therapies_and_New_Approaches","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":41993293,"first_name":"Helen","middle_initials":null,"last_name":"Christou","page_name":"HelenChristou","domain_name":"independent","created_at":"2016-01-24T03:37:57.009-08:00","display_name":"Helen Christou","url":"https://independent.academia.edu/HelenChristou"},"attachments":[{"id":104381461,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381461/thumbnails/1.jpg","file_name":"1179556518817322.pdf","download_url":"https://www.academia.edu/attachments/104381461/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bronchopulmonary_Dysplasia_An_Update_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381461/1179556518817322-libre.pdf?1689782496=\u0026response-content-disposition=attachment%3B+filename%3DBronchopulmonary_Dysplasia_An_Update_of.pdf\u0026Expires=1732412926\u0026Signature=BUVhFh080F0wOzhcey9mtq5JkhHaT4XCZqhXxUtRS7RBhONCDq6G91AdNl25mpVYlvwLBeO23sTw-SKE2Cnl8O3Ypr7dY7w~5-U~IKzHT~805gdkniXXof3fTneCHvwf26hf3N7OPGXG5pY3CiuevVy5S74cSuqoh8~-QQnnryZCwvXnGIT4HwieCTUuKOymbpb1RYtOUh1LWogWNg7dGFSCmaK9Du11OAjeHHi-IuWLkNQx4cqo1Y7gqnqLT349zOXrK~1zypsk1nd3fULjYScOXHujhhffXOiUFK74xr5xYuDQBdGtL5gzimY8QCJDUsbR3vSacwXRESY8OqjBEA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":104381460,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381460/thumbnails/1.jpg","file_name":"1179556518817322.pdf","download_url":"https://www.academia.edu/attachments/104381460/download_file","bulk_download_file_name":"Bronchopulmonary_Dysplasia_An_Update_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381460/1179556518817322-libre.pdf?1689782492=\u0026response-content-disposition=attachment%3B+filename%3DBronchopulmonary_Dysplasia_An_Update_of.pdf\u0026Expires=1732412926\u0026Signature=VRiLMjLH2uwkpIJF34W6Mv8AGomyA1cDPA0QQpdSHTcXkKabKwBaV1BneGhqxjGxrw4Qx~F~gBMwI3dMGjTDKjxzIpcMeDgQtDAZfXkbYsD2hRU5XIdchwaS8WPBK1oFtKIlnfhcJHuf8OfbUf9pplgbDk9wsTz-f67dCwHM4qpt2b87P8IyLgdcpP6BN67X6hAvKxggQPozaSbF5FyUDxZDJR51iQQtt0PctVEgLcOGE0g81Gu5zPuCICtBfvcxNLbAAgZY28xD90ZyKq~vji-hgoLINNlRuhlLhpH7YUQPKh5kKnAgpj7~RRQFW5jJKcTU0F-e6qVoGfz8m~29Lw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics"},{"id":5500,"name":"Incidence Geometry","url":"https://www.academia.edu/Documents/in/Incidence_Geometry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":70561,"name":"Low Birth Weight","url":"https://www.academia.edu/Documents/in/Low_Birth_Weight"},{"id":116278,"name":"Psychological Intervention","url":"https://www.academia.edu/Documents/in/Psychological_Intervention"},{"id":248620,"name":"Pharmacotherapy","url":"https://www.academia.edu/Documents/in/Pharmacotherapy"},{"id":568312,"name":"Intensive Care Medicine","url":"https://www.academia.edu/Documents/in/Intensive_Care_Medicine"},{"id":633452,"name":"Bronchopulmonary Dysplasia","url":"https://www.academia.edu/Documents/in/Bronchopulmonary_Dysplasia"}],"urls":[{"id":32973567,"url":"http://journals.sagepub.com/doi/pdf/10.1177/1179556518817322"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730362"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730362/Adjuvant_Effect_of_Bacille_Calmette_Gu%C3%A9rin_on_Hepatitis_B_Vaccine_Immunogenicity_in_the_Preterm_and_Term_Newborn"><img alt="Research paper thumbnail of Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn" class="work-thumbnail" src="https://attachments.academia-assets.com/104381489/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730362/Adjuvant_Effect_of_Bacille_Calmette_Gu%C3%A9rin_on_Hepatitis_B_Vaccine_Immunogenicity_in_the_Preterm_and_Term_Newborn">Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn</a></div><div class="wp-workCard_item"><span>Frontiers in immunology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Immunization is key to protecting term and preterm infants from a heightened risk of infection. H...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Immunization is key to protecting term and preterm infants from a heightened risk of infection. However, preterm immunity is distinct from that of the term, limiting its ability to effectively respond to vaccines routinely given at birth, such as hepatitis B vaccine (HBV). As part of the Expanded Program on Immunization, HBV is often given together with the live-attenuated vaccine Bacille Calmette-Guérin (BCG), known to activate multiple pattern-recognition receptors. Of note, some clinical studies suggest BCG can enhance efficacy of other vaccines in term newborns. However, little is known about whether BCG can shape Th-polarizing cytokine responses to HBV nor the age-dependency of such effects, including whether they may extend to the preterm. To characterize the effects of BCG on HBV immunogenicity, we studied individual and combined administration of these vaccines to cord newborn and adult human whole blood and mononuclear cellsand to neonatal and adult mice. Compared to either...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="efa79321ee5c69dda3c5759237fd8eb0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381489,"asset_id":104730362,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381489/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730362"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730362"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730362; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730362]").text(description); $(".js-view-count[data-work-id=104730362]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730362; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730362']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730362, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "efa79321ee5c69dda3c5759237fd8eb0" } } $('.js-work-strip[data-work-id=104730362]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730362,"title":"Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn","translated_title":"","metadata":{"abstract":"Immunization is key to protecting term and preterm infants from a heightened risk of infection. However, preterm immunity is distinct from that of the term, limiting its ability to effectively respond to vaccines routinely given at birth, such as hepatitis B vaccine (HBV). As part of the Expanded Program on Immunization, HBV is often given together with the live-attenuated vaccine Bacille Calmette-Guérin (BCG), known to activate multiple pattern-recognition receptors. Of note, some clinical studies suggest BCG can enhance efficacy of other vaccines in term newborns. However, little is known about whether BCG can shape Th-polarizing cytokine responses to HBV nor the age-dependency of such effects, including whether they may extend to the preterm. To characterize the effects of BCG on HBV immunogenicity, we studied individual and combined administration of these vaccines to cord newborn and adult human whole blood and mononuclear cellsand to neonatal and adult mice. 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To characterize the effects of BCG on HBV immunogenicity, we studied individual and combined administration of these vaccines to cord newborn and adult human whole blood and mononuclear cellsand to neonatal and adult mice. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730361"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730361/Impaired_Pulmonary_Arterial_Vasoconstriction_and_Nitric_Oxide_Mediated_Relaxation_Underlie_Severe_Pulmonary_Hypertension_in_Sugen_Hypoxia_Rat_Model"><img alt="Research paper thumbnail of Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in Sugen-Hypoxia Rat Model" class="work-thumbnail" src="https://attachments.academia-assets.com/104381484/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730361/Impaired_Pulmonary_Arterial_Vasoconstriction_and_Nitric_Oxide_Mediated_Relaxation_Underlie_Severe_Pulmonary_Hypertension_in_Sugen_Hypoxia_Rat_Model">Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in Sugen-Hypoxia Rat Model</a></div><div class="wp-workCard_item"><span>The Journal of pharmacology and experimental therapeutics</span><span>, Jan 6, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the progn...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and examined the underlying mechanisms, in the sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with sugen (20 mg/kg sc) and exposed to hypoxia (9% O2) for 3 weeks followed by 4 weeks in normoxia (Su/Hx), or treated with sugen alone (Su) or hypoxia alone (Hx) or neither (Nx). After hemodynamic measurements, the heart was assessed for right ventricular hypertrophy (Fulton&#39;s Index), the pulmonary artery, aorta and mesenteric arteries were isolated for vascular function studies, and contractile markers were measured in pulmonary artery using quantitative PCR. Other rats were used for morphometric analysis of pulmonary vascular remodeling. Right ventricular systolic pressure and Fulton&#39;s Index were higher in Su/Hx vs Su, Hx and Nx rats. Pulmonary vascular remode...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e978f6c81e6882a82c6438f862d78b5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381484,"asset_id":104730361,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381484/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730361"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730361"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730361; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730361]").text(description); $(".js-view-count[data-work-id=104730361]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730361; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730361']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730361, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0e978f6c81e6882a82c6438f862d78b5" } } $('.js-work-strip[data-work-id=104730361]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730361,"title":"Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in Sugen-Hypoxia Rat Model","translated_title":"","metadata":{"abstract":"Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and examined the underlying mechanisms, in the sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with sugen (20 mg/kg sc) and exposed to hypoxia (9% O2) for 3 weeks followed by 4 weeks in normoxia (Su/Hx), or treated with sugen alone (Su) or hypoxia alone (Hx) or neither (Nx). After hemodynamic measurements, the heart was assessed for right ventricular hypertrophy (Fulton\u0026#39;s Index), the pulmonary artery, aorta and mesenteric arteries were isolated for vascular function studies, and contractile markers were measured in pulmonary artery using quantitative PCR. Other rats were used for morphometric analysis of pulmonary vascular remodeling. Right ventricular systolic pressure and Fulton\u0026#39;s Index were higher in Su/Hx vs Su, Hx and Nx rats. Pulmonary vascular remode...","publication_date":{"day":6,"month":1,"year":2017,"errors":{}},"publication_name":"The Journal of pharmacology and experimental therapeutics"},"translated_abstract":"Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and examined the underlying mechanisms, in the sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with sugen (20 mg/kg sc) and exposed to hypoxia (9% O2) for 3 weeks followed by 4 weeks in normoxia (Su/Hx), or treated with sugen alone (Su) or hypoxia alone (Hx) or neither (Nx). After hemodynamic measurements, the heart was assessed for right ventricular hypertrophy (Fulton\u0026#39;s Index), the pulmonary artery, aorta and mesenteric arteries were isolated for vascular function studies, and contractile markers were measured in pulmonary artery using quantitative PCR. 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href="https://www.academia.edu/104730359/Cord_Blood_Adipocyte_Fatty_Acid_Binding_Protein_Levels_Correlate_With_Gestational_Age_and_Birth_Weight_in_Neonates"><img alt="Research paper thumbnail of Cord Blood Adipocyte Fatty Acid-Binding Protein Levels Correlate With Gestational Age and Birth Weight in Neonates" class="work-thumbnail" src="https://attachments.academia-assets.com/104381493/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730359/Cord_Blood_Adipocyte_Fatty_Acid_Binding_Protein_Levels_Correlate_With_Gestational_Age_and_Birth_Weight_in_Neonates">Cord Blood Adipocyte Fatty Acid-Binding Protein Levels Correlate With Gestational Age and Birth Weight in Neonates</a></div><div class="wp-workCard_item"><span>The Journal of clinical endocrinology and metabolism</span><span>, May 1, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Infants born small for gestational age (SGA) have increased risk for obesity and metabolic syndro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Infants born small for gestational age (SGA) have increased risk for obesity and metabolic syndrome, but the underlying mechanisms are not fully elucidated. Adipocyte fatty acid-binding protein (AFABP) is an adipokine that has been implicated in modulation of insulin sensitivity and lipid metabolism. Higher plasma AFABP levels are associated with increased risk of metabolic syndrome and cardiovascular morbidity in adults. Alterations in AFABP levels during fetal growth have not been characterized. To examine AFABP levels in neonatal cord blood in relation to gestational age and birth weight. A cross-sectional study of 361 neonates born at a tertiary academic center. Plasma AFABP levels were measured by enzyme-linked immunosorbent assay. For comparison, venous samples from 26 adults were analyzed. AFABP levels were higher in neonates compared with adults (P &lt; 0.01). Preterm infants had higher AFABP levels [48.2 (31.2 to 73.3) ng/mL] compared with full-term infants [35.8 (25.1 to 5...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0cad319802331f59e376186dc1d8495a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381493,"asset_id":104730359,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381493/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730359"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730359"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730359; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730359]").text(description); $(".js-view-count[data-work-id=104730359]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730359; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730359']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730359, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0cad319802331f59e376186dc1d8495a" } } $('.js-work-strip[data-work-id=104730359]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730359,"title":"Cord Blood Adipocyte Fatty Acid-Binding Protein Levels Correlate With Gestational Age and Birth Weight in Neonates","translated_title":"","metadata":{"abstract":"Infants born small for gestational age (SGA) have increased risk for obesity and metabolic syndrome, but the underlying mechanisms are not fully elucidated. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4458329" id="papers"><div class="js-work-strip profile--work_container" data-work-id="104730378"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730378/Acetazolamide_Modulates_Pulmonary_Inflammation_and_Ameliorates_Severe_Experimental_Pulmonary_Hypertension"><img alt="Research paper thumbnail of Acetazolamide Modulates Pulmonary Inflammation and Ameliorates Severe Experimental Pulmonary Hypertension" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730378/Acetazolamide_Modulates_Pulmonary_Inflammation_and_Ameliorates_Severe_Experimental_Pulmonary_Hypertension">Acetazolamide Modulates Pulmonary Inflammation and Ameliorates Severe Experimental Pulmonary Hypertension</a></div><div class="wp-workCard_item"><span>Pediatrics</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Inflammatory cytokines and several immune cells including macrophages contribute to t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Inflammatory cytokines and several immune cells including macrophages contribute to the pathobiology of Pulmonary Arterial Hypertension (PAH). Carbonic anhydrase inhibition and acidosis were reported to be involved in immune modulation, but their effects in chronic pulmonary inflammation in PAH are unknown. Objective: To evaluate whether ACTZ can ameliorate severe experimental PH. by modulating pulmonary inflammation. Design/Methods: In the Sugen 5416/hypoxia (SU/Hx) rat model of severe PH, ACTZ or ammonium chloride (NH4Cl) were administered in the drinking water. (see image for experimental timelines). We assessed right ventricular systolic pressure (RVSP), right ventricular hypertrophy (RVH as Fulton’s Index, FI) and pulmonary vascular remodeling. Expression of …</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730378"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730378"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730378; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730378]").text(description); $(".js-view-count[data-work-id=104730378]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730378; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730378']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730378, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104730378]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730378,"title":"Acetazolamide Modulates Pulmonary Inflammation and Ameliorates Severe Experimental Pulmonary Hypertension","translated_title":"","metadata":{"abstract":"Background: Inflammatory cytokines and several immune cells including macrophages contribute to the pathobiology of Pulmonary Arterial Hypertension (PAH). Carbonic anhydrase inhibition and acidosis were reported to be involved in immune modulation, but their effects in chronic pulmonary inflammation in PAH are unknown. Objective: To evaluate whether ACTZ can ameliorate severe experimental PH. by modulating pulmonary inflammation. Design/Methods: In the Sugen 5416/hypoxia (SU/Hx) rat model of severe PH, ACTZ or ammonium chloride (NH4Cl) were administered in the drinking water. (see image for experimental timelines). We assessed right ventricular systolic pressure (RVSP), right ventricular hypertrophy (RVH as Fulton’s Index, FI) and pulmonary vascular remodeling. Expression of …","publisher":"American Academy of Pediatrics (AAP)","publication_name":"Pediatrics"},"translated_abstract":"Background: Inflammatory cytokines and several immune cells including macrophages contribute to the pathobiology of Pulmonary Arterial Hypertension (PAH). Carbonic anhydrase inhibition and acidosis were reported to be involved in immune modulation, but their effects in chronic pulmonary inflammation in PAH are unknown. Objective: To evaluate whether ACTZ can ameliorate severe experimental PH. by modulating pulmonary inflammation. Design/Methods: In the Sugen 5416/hypoxia (SU/Hx) rat model of severe PH, ACTZ or ammonium chloride (NH4Cl) were administered in the drinking water. (see image for experimental timelines). We assessed right ventricular systolic pressure (RVSP), right ventricular hypertrophy (RVH as Fulton’s Index, FI) and pulmonary vascular remodeling. Expression of …","internal_url":"https://www.academia.edu/104730378/Acetazolamide_Modulates_Pulmonary_Inflammation_and_Ameliorates_Severe_Experimental_Pulmonary_Hypertension","translated_internal_url":"","created_at":"2023-07-19T08:48:24.461-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":41993293,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Acetazolamide_Modulates_Pulmonary_Inflammation_and_Ameliorates_Severe_Experimental_Pulmonary_Hypertension","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":41993293,"first_name":"Helen","middle_initials":null,"last_name":"Christou","page_name":"HelenChristou","domain_name":"independent","created_at":"2016-01-24T03:37:57.009-08:00","display_name":"Helen Christou","url":"https://independent.academia.edu/HelenChristou"},"attachments":[],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology"},{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system"},{"id":462040,"name":"Acetazolamide","url":"https://www.academia.edu/Documents/in/Acetazolamide"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3804974,"name":"right ventricular hypertrophy","url":"https://www.academia.edu/Documents/in/right_ventricular_hypertrophy"}],"urls":[{"id":32973579,"url":"https://publications.aap.org/pediatrics/article/144/2_MeetingAbstract/695/3814/Acetazolamide-Modulates-Pulmonary-Inflammation-and"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730377"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730377/Skeletal_Muscle_Dysfunction_in_Experimental_Pulmonary_Hypertension"><img alt="Research paper thumbnail of Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension" class="work-thumbnail" src="https://attachments.academia-assets.com/104381467/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730377/Skeletal_Muscle_Dysfunction_in_Experimental_Pulmonary_Hypertension">Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that is ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that is in urgent need of improved therapies that treat it. One of the remaining therapeutic challenges is the increasingly recognized skeletal muscle dysfunction that interferes with exercise tolerance. Here we report that in the adult rat Sugen/hypoxia (SU/Hx) model of severe pulmonary hypertension (PH), there is highly significant, almost 50%, decrease in exercise endurance, and this is associated with a 25% increase in the abundance of type II muscle fiber markers, thick sarcomeric aggregates and an increase in the levels of FoxO1 in the soleus (a predominantly type I fiber muscle), with additional alterations in the transcriptomic profiles of the diaphragm (a mixed fiber muscle) and the extensor digitorum longus (a predominantly Type II fiber muscle). In addition, soleus atrophy may contribute to impaired exercise endurance. Studies in L6 rat myoblasts have showed that myotube differentiati...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ecb8e288f2e080bc5a0d2751a98709fc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381467,"asset_id":104730377,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381467/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730377"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730377"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730377; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730377]").text(description); $(".js-view-count[data-work-id=104730377]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730377; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730377']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730377, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ecb8e288f2e080bc5a0d2751a98709fc" } } $('.js-work-strip[data-work-id=104730377]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730377,"title":"Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension","translated_title":"","metadata":{"abstract":"Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that is in urgent need of improved therapies that treat it. One of the remaining therapeutic challenges is the increasingly recognized skeletal muscle dysfunction that interferes with exercise tolerance. Here we report that in the adult rat Sugen/hypoxia (SU/Hx) model of severe pulmonary hypertension (PH), there is highly significant, almost 50%, decrease in exercise endurance, and this is associated with a 25% increase in the abundance of type II muscle fiber markers, thick sarcomeric aggregates and an increase in the levels of FoxO1 in the soleus (a predominantly type I fiber muscle), with additional alterations in the transcriptomic profiles of the diaphragm (a mixed fiber muscle) and the extensor digitorum longus (a predominantly Type II fiber muscle). In addition, soleus atrophy may contribute to impaired exercise endurance. Studies in L6 rat myoblasts have showed that myotube differentiati...","publisher":"MDPI AG","publication_name":"International Journal of Molecular Sciences"},"translated_abstract":"Pulmonary arterial hypertension (PAH) is a serious, progressive, and often fatal disease that is in urgent need of improved therapies that treat it. One of the remaining therapeutic challenges is the increasingly recognized skeletal muscle dysfunction that interferes with exercise tolerance. Here we report that in the adult rat Sugen/hypoxia (SU/Hx) model of severe pulmonary hypertension (PH), there is highly significant, almost 50%, decrease in exercise endurance, and this is associated with a 25% increase in the abundance of type II muscle fiber markers, thick sarcomeric aggregates and an increase in the levels of FoxO1 in the soleus (a predominantly type I fiber muscle), with additional alterations in the transcriptomic profiles of the diaphragm (a mixed fiber muscle) and the extensor digitorum longus (a predominantly Type II fiber muscle). In addition, soleus atrophy may contribute to impaired exercise endurance. Studies in L6 rat myoblasts have showed that myotube differentiati...","internal_url":"https://www.academia.edu/104730377/Skeletal_Muscle_Dysfunction_in_Experimental_Pulmonary_Hypertension","translated_internal_url":"","created_at":"2023-07-19T08:48:24.275-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":41993293,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":104381467,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381467/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/104381467/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Skeletal_Muscle_Dysfunction_in_Experimen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381467/pdf-libre.pdf?1689782519=\u0026response-content-disposition=attachment%3B+filename%3DSkeletal_Muscle_Dysfunction_in_Experimen.pdf\u0026Expires=1732412926\u0026Signature=N-C0HN2VFHvKp1i0yzTOCmX40d4Yh9MOWXINOUqorPvNvM80SJmbjkjNkppf24eaBMyyMsQy4lXou~845ScnAOzR36q0iU5L-62kpSIo3Hanlih46pwUcbpLgsevnHHeEQ38URRCO-QnEZr~yrIQVXaJeJiBe9BBG1f-kCr4GdG5XkK2qjoEUyXFWH4FhsJd5S6rzf5WXfoocO1p8BqVTHljLVct7Z9WKER3WDjz~AsX5sxV~pWpMCRs3n4Gkv6GYZFzKKjkPMQ48M1FaR~fxCLnaSAhbaVPIO4sc2YIGLc2ubkb8dnAkbGMWPGSjxk~FNrExdJFWrPgSJX8iUsYNQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Skeletal_Muscle_Dysfunction_in_Experimental_Pulmonary_Hypertension","translated_slug":"","page_count":21,"language":"en","content_type":"Work","owner":{"id":41993293,"first_name":"Helen","middle_initials":null,"last_name":"Christou","page_name":"HelenChristou","domain_name":"independent","created_at":"2016-01-24T03:37:57.009-08:00","display_name":"Helen Christou","url":"https://independent.academia.edu/HelenChristou"},"attachments":[{"id":104381467,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381467/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/104381467/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Skeletal_Muscle_Dysfunction_in_Experimen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381467/pdf-libre.pdf?1689782519=\u0026response-content-disposition=attachment%3B+filename%3DSkeletal_Muscle_Dysfunction_in_Experimen.pdf\u0026Expires=1732412926\u0026Signature=N-C0HN2VFHvKp1i0yzTOCmX40d4Yh9MOWXINOUqorPvNvM80SJmbjkjNkppf24eaBMyyMsQy4lXou~845ScnAOzR36q0iU5L-62kpSIo3Hanlih46pwUcbpLgsevnHHeEQ38URRCO-QnEZr~yrIQVXaJeJiBe9BBG1f-kCr4GdG5XkK2qjoEUyXFWH4FhsJd5S6rzf5WXfoocO1p8BqVTHljLVct7Z9WKER3WDjz~AsX5sxV~pWpMCRs3n4Gkv6GYZFzKKjkPMQ48M1FaR~fxCLnaSAhbaVPIO4sc2YIGLc2ubkb8dnAkbGMWPGSjxk~FNrExdJFWrPgSJX8iUsYNQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":276821,"name":"Molecular sciences","url":"https://www.academia.edu/Documents/in/Molecular_sciences"},{"id":357849,"name":"Skeletal Muscle","url":"https://www.academia.edu/Documents/in/Skeletal_Muscle"},{"id":585049,"name":"Myocyte","url":"https://www.academia.edu/Documents/in/Myocyte"},{"id":2807671,"name":"Soleus muscle","url":"https://www.academia.edu/Documents/in/Soleus_muscle"}],"urls":[{"id":32973578,"url":"https://www.mdpi.com/1422-0067/23/18/10912/pdf"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730375"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730375/Adipokines_and_Metabolic_Regulators_in_Human_and_Experimental_Pulmonary_Arterial_Hypertension"><img alt="Research paper thumbnail of Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension" class="work-thumbnail" src="https://attachments.academia-assets.com/104381466/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730375/Adipokines_and_Metabolic_Regulators_in_Human_and_Experimental_Pulmonary_Arterial_Hypertension">Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pulmonary hypertension (PH) is associated with meta-inflammation related to obesity but the role ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pulmonary hypertension (PH) is associated with meta-inflammation related to obesity but the role of adipose tissue in PH pathogenesis is unknown. We hypothesized that adipose tissue-derived metabolic regulators are altered in human and experimental PH. We measured circulating levels of fatty acid binding protein 4 (FABP-4), fibroblast growth factor -21 (FGF-21), adiponectin, and the mRNA levels of FABP-4, FGF-21, and peroxisome proliferator-activated receptor γ (PPARγ) in lung tissue of patients with idiopathic PH and healthy controls. We also evaluated lung and adipose tissue expression of these mediators in the three most commonly used experimental rodent models of pulmonary hypertension. Circulating levels of FABP-4, FGF-21, and adiponectin were significantly elevated in PH patients compared to controls and the mRNA levels of these regulators and PPARγ were also significantly increased in human PH lungs and in the lungs of rats with experimental PH compared to controls. These fin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9a63c9ecf199fbe2f8aded1654f7c4b2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381466,"asset_id":104730375,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381466/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730375"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730375"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730375; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730375]").text(description); $(".js-view-count[data-work-id=104730375]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730375; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730375']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730375, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9a63c9ecf199fbe2f8aded1654f7c4b2" } } $('.js-work-strip[data-work-id=104730375]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730375,"title":"Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension","translated_title":"","metadata":{"abstract":"Pulmonary hypertension (PH) is associated with meta-inflammation related to obesity but the role of adipose tissue in PH pathogenesis is unknown. We hypothesized that adipose tissue-derived metabolic regulators are altered in human and experimental PH. We measured circulating levels of fatty acid binding protein 4 (FABP-4), fibroblast growth factor -21 (FGF-21), adiponectin, and the mRNA levels of FABP-4, FGF-21, and peroxisome proliferator-activated receptor γ (PPARγ) in lung tissue of patients with idiopathic PH and healthy controls. We also evaluated lung and adipose tissue expression of these mediators in the three most commonly used experimental rodent models of pulmonary hypertension. Circulating levels of FABP-4, FGF-21, and adiponectin were significantly elevated in PH patients compared to controls and the mRNA levels of these regulators and PPARγ were also significantly increased in human PH lungs and in the lungs of rats with experimental PH compared to controls. These fin...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"International Journal of Molecular Sciences"},"translated_abstract":"Pulmonary hypertension (PH) is associated with meta-inflammation related to obesity but the role of adipose tissue in PH pathogenesis is unknown. We hypothesized that adipose tissue-derived metabolic regulators are altered in human and experimental PH. We measured circulating levels of fatty acid binding protein 4 (FABP-4), fibroblast growth factor -21 (FGF-21), adiponectin, and the mRNA levels of FABP-4, FGF-21, and peroxisome proliferator-activated receptor γ (PPARγ) in lung tissue of patients with idiopathic PH and healthy controls. We also evaluated lung and adipose tissue expression of these mediators in the three most commonly used experimental rodent models of pulmonary hypertension. Circulating levels of FABP-4, FGF-21, and adiponectin were significantly elevated in PH patients compared to controls and the mRNA levels of these regulators and PPARγ were also significantly increased in human PH lungs and in the lungs of rats with experimental PH compared to controls. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730370"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730370/Acetazolamide_Improves_Right_Ventricular_Function_and_Metabolic_Gene_Dysregulation_in_Experimental_Pulmonary_Arterial_Hypertension"><img alt="Research paper thumbnail of Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension" class="work-thumbnail" src="https://attachments.academia-assets.com/104381495/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730370/Acetazolamide_Improves_Right_Ventricular_Function_and_Metabolic_Gene_Dysregulation_in_Experimental_Pulmonary_Arterial_Hypertension">Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension</a></div><div class="wp-workCard_item"><span>Frontiers in Cardiovascular Medicine</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Right ventricular (RV) performance is a key determinant of mortality in pulmonary art...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Right ventricular (RV) performance is a key determinant of mortality in pulmonary arterial hypertension (PAH). RV failure is characterized by metabolic dysregulation with unbalanced anaerobic glycolysis, oxidative phosphorylation, and fatty acid oxidation (FAO). We previously found that acetazolamide (ACTZ) treatment modulates the pulmonary inflammatory response and ameliorates experimental PAH.Objective: To evaluate the effect of ACTZ treatment on RV function and metabolic profile in experimental PAH.Design/Methods: In the Sugen 5416/hypoxia (SuHx) rat model of severe PAH, RV transcriptomic analysis was performed by RNA-seq, and top metabolic targets were validated by RT-PCR. We assessed the effect of therapeutic administration of ACTZ in the drinking water on hemodynamics by catheterization [right and left ventricular systolic pressure (RVSP and LVSP, respectively)] and echocardiography [pulmonary artery acceleration time (PAAT), RV wall thickness in diastole (RVWT), R...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="04fa5ab9f5795103f4a622d27206d691" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381495,"asset_id":104730370,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381495/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730370"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730370"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730370; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730370]").text(description); $(".js-view-count[data-work-id=104730370]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730370; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730370']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730370, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "04fa5ab9f5795103f4a622d27206d691" } } $('.js-work-strip[data-work-id=104730370]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730370,"title":"Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension","translated_title":"","metadata":{"abstract":"Background: Right ventricular (RV) performance is a key determinant of mortality in pulmonary arterial hypertension (PAH). RV failure is characterized by metabolic dysregulation with unbalanced anaerobic glycolysis, oxidative phosphorylation, and fatty acid oxidation (FAO). We previously found that acetazolamide (ACTZ) treatment modulates the pulmonary inflammatory response and ameliorates experimental PAH.Objective: To evaluate the effect of ACTZ treatment on RV function and metabolic profile in experimental PAH.Design/Methods: In the Sugen 5416/hypoxia (SuHx) rat model of severe PAH, RV transcriptomic analysis was performed by RNA-seq, and top metabolic targets were validated by RT-PCR. We assessed the effect of therapeutic administration of ACTZ in the drinking water on hemodynamics by catheterization [right and left ventricular systolic pressure (RVSP and LVSP, respectively)] and echocardiography [pulmonary artery acceleration time (PAAT), RV wall thickness in diastole (RVWT), R...","publisher":"Frontiers Media SA","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Frontiers in Cardiovascular Medicine"},"translated_abstract":"Background: Right ventricular (RV) performance is a key determinant of mortality in pulmonary arterial hypertension (PAH). RV failure is characterized by metabolic dysregulation with unbalanced anaerobic glycolysis, oxidative phosphorylation, and fatty acid oxidation (FAO). We previously found that acetazolamide (ACTZ) treatment modulates the pulmonary inflammatory response and ameliorates experimental PAH.Objective: To evaluate the effect of ACTZ treatment on RV function and metabolic profile in experimental PAH.Design/Methods: In the Sugen 5416/hypoxia (SuHx) rat model of severe PAH, RV transcriptomic analysis was performed by RNA-seq, and top metabolic targets were validated by RT-PCR. We assessed the effect of therapeutic administration of ACTZ in the drinking water on hemodynamics by catheterization [right and left ventricular systolic pressure (RVSP and LVSP, respectively)] and echocardiography [pulmonary artery acceleration time (PAAT), RV wall thickness in diastole (RVWT), R...","internal_url":"https://www.academia.edu/104730370/Acetazolamide_Improves_Right_Ventricular_Function_and_Metabolic_Gene_Dysregulation_in_Experimental_Pulmonary_Arterial_Hypertension","translated_internal_url":"","created_at":"2023-07-19T08:48:23.014-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":41993293,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":104381495,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381495/thumbnails/1.jpg","file_name":"fcvm-08-662870.pdf","download_url":"https://www.academia.edu/attachments/104381495/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acetazolamide_Improves_Right_Ventricular.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381495/fcvm-08-662870-libre.pdf?1689782481=\u0026response-content-disposition=attachment%3B+filename%3DAcetazolamide_Improves_Right_Ventricular.pdf\u0026Expires=1732412926\u0026Signature=IcXem9TF8FOYQYVXql9NP6PKVNpTzMHa3Y-TtxJUGWxZ58K4d6QlJW~hBjc4ZHuOy8FKCtbpzhv2R6wKLW5Ky9Cg7jQk3MbapsQg7-SBr9A3BNOosEhe10j4b98gTlxc4dumeXEi0SCmfQW2Dr5oIs0BdbT1XlVG4-JbTEll0EA4tlLcKERq58MojxJGU5iBCUJY9CJcmMI~3sYWTmkYG8US9jgrtfaaIQ1Xrye1t6o0Q2kB7cN5uF9SE0fkUNhxHp0rEimjMrPCp9O6dvuBA06ibHqCo7NBw6KkFDfv74HVTY59Tkr-MwKWUaRXGQzGjNc-cjQUGC8xukD2mNUZcw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Acetazolamide_Improves_Right_Ventricular_Function_and_Metabolic_Gene_Dysregulation_in_Experimental_Pulmonary_Arterial_Hypertension","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":41993293,"first_name":"Helen","middle_initials":null,"last_name":"Christou","page_name":"HelenChristou","domain_name":"independent","created_at":"2016-01-24T03:37:57.009-08:00","display_name":"Helen Christou","url":"https://independent.academia.edu/HelenChristou"},"attachments":[{"id":104381495,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381495/thumbnails/1.jpg","file_name":"fcvm-08-662870.pdf","download_url":"https://www.academia.edu/attachments/104381495/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acetazolamide_Improves_Right_Ventricular.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381495/fcvm-08-662870-libre.pdf?1689782481=\u0026response-content-disposition=attachment%3B+filename%3DAcetazolamide_Improves_Right_Ventricular.pdf\u0026Expires=1732412926\u0026Signature=IcXem9TF8FOYQYVXql9NP6PKVNpTzMHa3Y-TtxJUGWxZ58K4d6QlJW~hBjc4ZHuOy8FKCtbpzhv2R6wKLW5Ky9Cg7jQk3MbapsQg7-SBr9A3BNOosEhe10j4b98gTlxc4dumeXEi0SCmfQW2Dr5oIs0BdbT1XlVG4-JbTEll0EA4tlLcKERq58MojxJGU5iBCUJY9CJcmMI~3sYWTmkYG8US9jgrtfaaIQ1Xrye1t6o0Q2kB7cN5uF9SE0fkUNhxHp0rEimjMrPCp9O6dvuBA06ibHqCo7NBw6KkFDfv74HVTY59Tkr-MwKWUaRXGQzGjNc-cjQUGC8xukD2mNUZcw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":2369445,"name":"Pulmonary Artery","url":"https://www.academia.edu/Documents/in/Pulmonary_Artery"},{"id":4238921,"name":"beta oxidation","url":"https://www.academia.edu/Documents/in/beta_oxidation"}],"urls":[{"id":32973573,"url":"https://www.frontiersin.org/articles/10.3389/fcvm.2021.662870/full"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730369"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730369/Metabolomic_and_transcriptomic_signatures_of_prenatal_excessive_methionine_support_nature_rather_than_nurture_in_schizophrenia_pathogenesis"><img alt="Research paper thumbnail of Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis" class="work-thumbnail" src="https://attachments.academia-assets.com/104381464/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730369/Metabolomic_and_transcriptomic_signatures_of_prenatal_excessive_methionine_support_nature_rather_than_nurture_in_schizophrenia_pathogenesis">Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis</a></div><div class="wp-workCard_item"><span>Communications Biology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The imbalance of prenatal micronutrients may perturb one-carbon (C1) metabolism and increase the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The imbalance of prenatal micronutrients may perturb one-carbon (C1) metabolism and increase the risk for neuropsychiatric disorders. Prenatal excessive methionine (MET) produces in mice behavioral phenotypes reminiscent of human schizophrenia. Whether in-utero programming or early life caregiving mediate these effects is, however, unknown. Here, we show that the behavioral deficits of MET are independent of the early life mother-infant interaction. We also show that MET produces in early life profound changes in the brain C1 pathway components as well as glutamate transmission, mitochondrial function, and lipid metabolism. Bioinformatics analysis integrating metabolomics and transcriptomic data reveal dysregulations of glutamate transmission and lipid metabolism, and identify perturbed pathways of methylation and redox reactions. Our transcriptomics Linkage analysis of MET mice and schizophrenia subjects reveals master genes involved in inflammation and myelination. Finally, we ide...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="19ef782d3c95e00de4c452729bf8c313" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381464,"asset_id":104730369,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381464/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730369"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730369"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730369; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730369]").text(description); $(".js-view-count[data-work-id=104730369]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730369; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730369']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730369, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "19ef782d3c95e00de4c452729bf8c313" } } $('.js-work-strip[data-work-id=104730369]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730369,"title":"Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis","translated_title":"","metadata":{"abstract":"The imbalance of prenatal micronutrients may perturb one-carbon (C1) metabolism and increase the risk for neuropsychiatric disorders. Prenatal excessive methionine (MET) produces in mice behavioral phenotypes reminiscent of human schizophrenia. Whether in-utero programming or early life caregiving mediate these effects is, however, unknown. Here, we show that the behavioral deficits of MET are independent of the early life mother-infant interaction. We also show that MET produces in early life profound changes in the brain C1 pathway components as well as glutamate transmission, mitochondrial function, and lipid metabolism. Bioinformatics analysis integrating metabolomics and transcriptomic data reveal dysregulations of glutamate transmission and lipid metabolism, and identify perturbed pathways of methylation and redox reactions. Our transcriptomics Linkage analysis of MET mice and schizophrenia subjects reveals master genes involved in inflammation and myelination. Finally, we ide...","publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Communications Biology"},"translated_abstract":"The imbalance of prenatal micronutrients may perturb one-carbon (C1) metabolism and increase the risk for neuropsychiatric disorders. Prenatal excessive methionine (MET) produces in mice behavioral phenotypes reminiscent of human schizophrenia. Whether in-utero programming or early life caregiving mediate these effects is, however, unknown. Here, we show that the behavioral deficits of MET are independent of the early life mother-infant interaction. We also show that MET produces in early life profound changes in the brain C1 pathway components as well as glutamate transmission, mitochondrial function, and lipid metabolism. Bioinformatics analysis integrating metabolomics and transcriptomic data reveal dysregulations of glutamate transmission and lipid metabolism, and identify perturbed pathways of methylation and redox reactions. Our transcriptomics Linkage analysis of MET mice and schizophrenia subjects reveals master genes involved in inflammation and myelination. Finally, we ide...","internal_url":"https://www.academia.edu/104730369/Metabolomic_and_transcriptomic_signatures_of_prenatal_excessive_methionine_support_nature_rather_than_nurture_in_schizophrenia_pathogenesis","translated_internal_url":"","created_at":"2023-07-19T08:48:22.797-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":41993293,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":104381464,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381464/thumbnails/1.jpg","file_name":"s42003-020-01124-8.pdf","download_url":"https://www.academia.edu/attachments/104381464/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Metabolomic_and_transcriptomic_signature.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381464/s42003-020-01124-8-libre.pdf?1689782500=\u0026response-content-disposition=attachment%3B+filename%3DMetabolomic_and_transcriptomic_signature.pdf\u0026Expires=1732412926\u0026Signature=HE6X6lLtkUXQGdw~4rH-HAVg~J1mtvZ4k1giwqj6XAHX1krO8JIIoimIuxmdsifc4765Clr30x4I5hM7wKXWTKZ-5vWQJyktKQiTz6kYSzrO0BT6GFnHcx29jOK9Pisizc94mjeWkxIsjI0KjR0nEhF06sXg7fFaFf5syH23RyVwkmG0a8-8N5VMlS-Of8lPTMd0HXiZbgoZ0zAIGtBfcNHuxf65LcizeFdXKcdACPPD1NgLybRAYI~0ptR5RwM59Smib5tYS-pVKRkKwop7fhAcniiwg6AHgMh5Z0DNpsQ3QCIKrQinX1Wo2icy3w1Y7aWHG6-woFi5URnCKoRLRA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Metabolomic_and_transcriptomic_signatures_of_prenatal_excessive_methionine_support_nature_rather_than_nurture_in_schizophrenia_pathogenesis","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":41993293,"first_name":"Helen","middle_initials":null,"last_name":"Christou","page_name":"HelenChristou","domain_name":"independent","created_at":"2016-01-24T03:37:57.009-08:00","display_name":"Helen Christou","url":"https://independent.academia.edu/HelenChristou"},"attachments":[{"id":104381464,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381464/thumbnails/1.jpg","file_name":"s42003-020-01124-8.pdf","download_url":"https://www.academia.edu/attachments/104381464/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Metabolomic_and_transcriptomic_signature.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381464/s42003-020-01124-8-libre.pdf?1689782500=\u0026response-content-disposition=attachment%3B+filename%3DMetabolomic_and_transcriptomic_signature.pdf\u0026Expires=1732412926\u0026Signature=HE6X6lLtkUXQGdw~4rH-HAVg~J1mtvZ4k1giwqj6XAHX1krO8JIIoimIuxmdsifc4765Clr30x4I5hM7wKXWTKZ-5vWQJyktKQiTz6kYSzrO0BT6GFnHcx29jOK9Pisizc94mjeWkxIsjI0KjR0nEhF06sXg7fFaFf5syH23RyVwkmG0a8-8N5VMlS-Of8lPTMd0HXiZbgoZ0zAIGtBfcNHuxf65LcizeFdXKcdACPPD1NgLybRAYI~0ptR5RwM59Smib5tYS-pVKRkKwop7fhAcniiwg6AHgMh5Z0DNpsQ3QCIKrQinX1Wo2icy3w1Y7aWHG6-woFi5URnCKoRLRA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":7802,"name":"Metabolomics","url":"https://www.academia.edu/Documents/in/Metabolomics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":43761,"name":"Transcriptome","url":"https://www.academia.edu/Documents/in/Transcriptome"},{"id":3878940,"name":"Communications biology","url":"https://www.academia.edu/Documents/in/Communications_biology"}],"urls":[{"id":32973572,"url":"https://www.nature.com/articles/s42003-020-01124-8.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730368"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730368/Echocardiographic_markers_of_pulmonary_hemodynamics_and_right_ventricular_hypertrophy_in_rat_models_of_pulmonary_hypertension"><img alt="Research paper thumbnail of Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension" class="work-thumbnail" src="https://attachments.academia-assets.com/104381487/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730368/Echocardiographic_markers_of_pulmonary_hemodynamics_and_right_ventricular_hypertrophy_in_rat_models_of_pulmonary_hypertension">Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension</a></div><div class="wp-workCard_item"><span>Pulmonary Circulation</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Echocardiography is the gold standard non-invasive technique to diagnose pulmonary hypertension. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Echocardiography is the gold standard non-invasive technique to diagnose pulmonary hypertension. It is also an important modality used to monitor disease progression and response to treatment in patients with pulmonary hypertension. Surprisingly, only few studies have been conducted to validate and standardize echocardiographic parameters in experimental animal models of pulmonary hypertension. We sought to define cut-off values for both invasive and non-invasive measures of pulmonary hemodynamics and right ventricular hypertrophy that would reliably diagnose pulmonary hypertension in three different rat models. The study was designed in two phases: (1) a derivation phase to establish the cut-off values for invasive measures of right ventricular systolic pressure, Fulton&#39;s index (right ventricular weight/left ventricle + septum weight), right ventricular to body weight ratio, and non-invasive echocardiographic measures of pulmonary arterial acceleration time, pulmonary arterial ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bc8b86af036b71a92b5816c8828002e5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381487,"asset_id":104730368,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381487/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730368"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730368"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730368; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730368]").text(description); $(".js-view-count[data-work-id=104730368]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730368; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730368']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730368, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bc8b86af036b71a92b5816c8828002e5" } } $('.js-work-strip[data-work-id=104730368]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730368,"title":"Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension","translated_title":"","metadata":{"abstract":"Echocardiography is the gold standard non-invasive technique to diagnose pulmonary hypertension. It is also an important modality used to monitor disease progression and response to treatment in patients with pulmonary hypertension. Surprisingly, only few studies have been conducted to validate and standardize echocardiographic parameters in experimental animal models of pulmonary hypertension. We sought to define cut-off values for both invasive and non-invasive measures of pulmonary hemodynamics and right ventricular hypertrophy that would reliably diagnose pulmonary hypertension in three different rat models. The study was designed in two phases: (1) a derivation phase to establish the cut-off values for invasive measures of right ventricular systolic pressure, Fulton\u0026#39;s index (right ventricular weight/left ventricle + septum weight), right ventricular to body weight ratio, and non-invasive echocardiographic measures of pulmonary arterial acceleration time, pulmonary arterial ...","publisher":"Wiley","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Pulmonary Circulation"},"translated_abstract":"Echocardiography is the gold standard non-invasive technique to diagnose pulmonary hypertension. It is also an important modality used to monitor disease progression and response to treatment in patients with pulmonary hypertension. Surprisingly, only few studies have been conducted to validate and standardize echocardiographic parameters in experimental animal models of pulmonary hypertension. We sought to define cut-off values for both invasive and non-invasive measures of pulmonary hemodynamics and right ventricular hypertrophy that would reliably diagnose pulmonary hypertension in three different rat models. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730366"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730366/Control_of_Human_Hemoglobin_Switching_By_LIN28B_Mediated_Regulation_of_BCL11A_Translation"><img alt="Research paper thumbnail of Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation" class="work-thumbnail" src="https://attachments.academia-assets.com/104381486/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730366/Control_of_Human_Hemoglobin_Switching_By_LIN28B_Mediated_Regulation_of_BCL11A_Translation">Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation</a></div><div class="wp-workCard_item"><span>Blood</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Both sickle cell disease and β-thalassemia are major sources of morbidity and mortality worldwide...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Both sickle cell disease and β-thalassemia are major sources of morbidity and mortality worldwide. Continued production of the β-like γ-globin genes that form fetal hemoglobin after infancy has been shown to ameliorate the severity of these disorders. As a result, there has been considerable interest in understanding the underlying regulation of the physiologic fetal-to-adult hemoglobin switch in humans to be able to better manipulate this process for therapeutic purposes. To date, only a single factor, BCL11A, has been identified as being involved in the developmental regulation of human hemoglobin switching. BCL11A is a direct transcriptional repressor of the γ-globin genes. Moreover, BCL11A is expressed in a developmental stage-specific manner to regulate human hemoglobin switching. However, despite extensive studies, the mechanisms that act upstream to regulate BCL11A expression and thereby control hemoglobin switching have remained elusive. To gain further insights, we have dir...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="295e8d6029407e7d9e958581b9ea6d73" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381486,"asset_id":104730366,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381486/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730366"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730366"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730366; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730366]").text(description); $(".js-view-count[data-work-id=104730366]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730366; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730366']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730366, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "295e8d6029407e7d9e958581b9ea6d73" } } $('.js-work-strip[data-work-id=104730366]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730366,"title":"Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation","translated_title":"","metadata":{"abstract":"Both sickle cell disease and β-thalassemia are major sources of morbidity and mortality worldwide. Continued production of the β-like γ-globin genes that form fetal hemoglobin after infancy has been shown to ameliorate the severity of these disorders. As a result, there has been considerable interest in understanding the underlying regulation of the physiologic fetal-to-adult hemoglobin switch in humans to be able to better manipulate this process for therapeutic purposes. To date, only a single factor, BCL11A, has been identified as being involved in the developmental regulation of human hemoglobin switching. BCL11A is a direct transcriptional repressor of the γ-globin genes. Moreover, BCL11A is expressed in a developmental stage-specific manner to regulate human hemoglobin switching. However, despite extensive studies, the mechanisms that act upstream to regulate BCL11A expression and thereby control hemoglobin switching have remained elusive. To gain further insights, we have dir...","publisher":"American Society of Hematology","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Blood"},"translated_abstract":"Both sickle cell disease and β-thalassemia are major sources of morbidity and mortality worldwide. Continued production of the β-like γ-globin genes that form fetal hemoglobin after infancy has been shown to ameliorate the severity of these disorders. As a result, there has been considerable interest in understanding the underlying regulation of the physiologic fetal-to-adult hemoglobin switch in humans to be able to better manipulate this process for therapeutic purposes. To date, only a single factor, BCL11A, has been identified as being involved in the developmental regulation of human hemoglobin switching. BCL11A is a direct transcriptional repressor of the γ-globin genes. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730364"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730364/Macrophage_FABP4_is_required_for_neutrophil_recruitment_and_bacterial_clearance_in_Pseudomonas_aeruginosa_pneumonia"><img alt="Research paper thumbnail of Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia" class="work-thumbnail" src="https://attachments.academia-assets.com/104381494/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730364/Macrophage_FABP4_is_required_for_neutrophil_recruitment_and_bacterial_clearance_in_Pseudomonas_aeruginosa_pneumonia">Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia</a></div><div class="wp-workCard_item"><span>FASEB journal : official publication of the Federation of American Societies for Experimental Biology</span><span>, Jan 21, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fatty acid binding protein 4 (FABP4), an intracellular lipid chaperone and adipokine, is expresse...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fatty acid binding protein 4 (FABP4), an intracellular lipid chaperone and adipokine, is expressed by lung macrophages, but the function of macrophage-FABP4 remains elusive. We investigated the role of FABP4 in host defense in a murine model of Pseudomonas aeruginosa pneumonia. Compared with wild-type (WT) mice, FABP4-deficient (FABP4) mice exhibited decreased bacterial clearance and increased mortality when challenged intranasally with P. aeruginosa. These findings in FABP4 mice were associated with a delayed neutrophil recruitment into the lungs and were followed by greater acute lung injury and inflammation. Among leukocytes, only macrophages expressed FABP4 in WT mice with P. aeruginosa pneumonia. Chimeric FABP4 mice with WT bone marrow were protected from increased mortality seen in chimeric WT mice with FABP4 bone marrow during P. aeruginosa pneumonia, thus confirming the role of macrophages as the main source of protective FABP4 against that infection. There was less producti...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3241b1183891b4bd0e74977b25434925" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381494,"asset_id":104730364,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381494/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730364"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730364"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730364; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730364]").text(description); $(".js-view-count[data-work-id=104730364]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730364; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730364']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730364, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3241b1183891b4bd0e74977b25434925" } } $('.js-work-strip[data-work-id=104730364]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730364,"title":"Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia","translated_title":"","metadata":{"abstract":"Fatty acid binding protein 4 (FABP4), an intracellular lipid chaperone and adipokine, is expressed by lung macrophages, but the function of macrophage-FABP4 remains elusive. We investigated the role of FABP4 in host defense in a murine model of Pseudomonas aeruginosa pneumonia. Compared with wild-type (WT) mice, FABP4-deficient (FABP4) mice exhibited decreased bacterial clearance and increased mortality when challenged intranasally with P. aeruginosa. These findings in FABP4 mice were associated with a delayed neutrophil recruitment into the lungs and were followed by greater acute lung injury and inflammation. Among leukocytes, only macrophages expressed FABP4 in WT mice with P. aeruginosa pneumonia. Chimeric FABP4 mice with WT bone marrow were protected from increased mortality seen in chimeric WT mice with FABP4 bone marrow during P. aeruginosa pneumonia, thus confirming the role of macrophages as the main source of protective FABP4 against that infection. There was less producti...","publication_date":{"day":21,"month":1,"year":2018,"errors":{}},"publication_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},"translated_abstract":"Fatty acid binding protein 4 (FABP4), an intracellular lipid chaperone and adipokine, is expressed by lung macrophages, but the function of macrophage-FABP4 remains elusive. We investigated the role of FABP4 in host defense in a murine model of Pseudomonas aeruginosa pneumonia. Compared with wild-type (WT) mice, FABP4-deficient (FABP4) mice exhibited decreased bacterial clearance and increased mortality when challenged intranasally with P. aeruginosa. These findings in FABP4 mice were associated with a delayed neutrophil recruitment into the lungs and were followed by greater acute lung injury and inflammation. Among leukocytes, only macrophages expressed FABP4 in WT mice with P. aeruginosa pneumonia. Chimeric FABP4 mice with WT bone marrow were protected from increased mortality seen in chimeric WT mice with FABP4 bone marrow during P. aeruginosa pneumonia, thus confirming the role of macrophages as the main source of protective FABP4 against that infection. There was less producti...","internal_url":"https://www.academia.edu/104730364/Macrophage_FABP4_is_required_for_neutrophil_recruitment_and_bacterial_clearance_in_Pseudomonas_aeruginosa_pneumonia","translated_internal_url":"","created_at":"2023-07-19T08:48:21.870-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":41993293,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":104381494,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381494/thumbnails/1.jpg","file_name":"fj.201802002R20230719-1-c20kan.pdf","download_url":"https://www.academia.edu/attachments/104381494/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Macrophage_FABP4_is_required_for_neutrop.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381494/fj.201802002R20230719-1-c20kan-libre.pdf?1689782496=\u0026response-content-disposition=attachment%3B+filename%3DMacrophage_FABP4_is_required_for_neutrop.pdf\u0026Expires=1732412926\u0026Signature=Qi3Xl8jv15tfxDm95FpAM83VpyDvh4a35uDgG1-03ADJnbF3sHFIo2r~UFXJLIFiRpLvqHuqFkSszRe5coyKMue85ceqE8GJHGDGi5HPym3nXPQiVVi7nkJbZobmEtDPibXy2NSNk80YBglYH~MUI1CU-A~oWZSSm--tGhm46F~n1FTzaU0lXcTh2FYP4ZGr1JyYhOQXfeXhhjY3t09H6IYDxDvjCvKPWmhpP5fTXmiF9gNhFTgbpTm9koeNGKMiuJ~Z448a2sGuAjgzlarR9SOioNGoYrpgtf4d3m4UMGV6ChR2FKCuH4yovD-0Ws7j-an5~DEROURLTwbM-4sh3g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Macrophage_FABP4_is_required_for_neutrophil_recruitment_and_bacterial_clearance_in_Pseudomonas_aeruginosa_pneumonia","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":41993293,"first_name":"Helen","middle_initials":null,"last_name":"Christou","page_name":"HelenChristou","domain_name":"independent","created_at":"2016-01-24T03:37:57.009-08:00","display_name":"Helen Christou","url":"https://independent.academia.edu/HelenChristou"},"attachments":[{"id":104381494,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104381494/thumbnails/1.jpg","file_name":"fj.201802002R20230719-1-c20kan.pdf","download_url":"https://www.academia.edu/attachments/104381494/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Macrophage_FABP4_is_required_for_neutrop.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104381494/fj.201802002R20230719-1-c20kan-libre.pdf?1689782496=\u0026response-content-disposition=attachment%3B+filename%3DMacrophage_FABP4_is_required_for_neutrop.pdf\u0026Expires=1732412926\u0026Signature=Qi3Xl8jv15tfxDm95FpAM83VpyDvh4a35uDgG1-03ADJnbF3sHFIo2r~UFXJLIFiRpLvqHuqFkSszRe5coyKMue85ceqE8GJHGDGi5HPym3nXPQiVVi7nkJbZobmEtDPibXy2NSNk80YBglYH~MUI1CU-A~oWZSSm--tGhm46F~n1FTzaU0lXcTh2FYP4ZGr1JyYhOQXfeXhhjY3t09H6IYDxDvjCvKPWmhpP5fTXmiF9gNhFTgbpTm9koeNGKMiuJ~Z448a2sGuAjgzlarR9SOioNGoYrpgtf4d3m4UMGV6ChR2FKCuH4yovD-0Ws7j-an5~DEROURLTwbM-4sh3g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology"},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":225499,"name":"Pseudomonas aeruginosa","url":"https://www.academia.edu/Documents/in/Pseudomonas_aeruginosa"},{"id":295234,"name":"Chemokine","url":"https://www.academia.edu/Documents/in/Chemokine"},{"id":636395,"name":"Pseudomonas Aeruginosa","url":"https://www.academia.edu/Documents/in/Pseudomonas_Aeruginosa-1"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730363"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730363/Bronchopulmonary_Dysplasia_An_Update_of_Current_Pharmacologic_Therapies_and_New_Approaches"><img alt="Research paper thumbnail of Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches" class="work-thumbnail" src="https://attachments.academia-assets.com/104381461/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730363/Bronchopulmonary_Dysplasia_An_Update_of_Current_Pharmacologic_Therapies_and_New_Approaches">Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches</a></div><div class="wp-workCard_item"><span>Clinical Medicine Insights: Pediatrics</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of surviving extr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of surviving extremely preterm infants and is associated with significant health care utilization in infancy and beyond. Recent advances in neonatal care have resulted in improved survival of extremely low birth weight (ELBW) infants; however, the incidence of BPD has not been substantially impacted by novel interventions in this vulnerable population. The multifactorial cause of BPD requires a multi-pronged approach for prevention and treatment. New approaches in assisted ventilation, optimal nutrition, and pharmacologic interventions are currently being evaluated. The focus of this review is the current state of the evidence for pharmacotherapy in BPD. Promising future approaches in need of further study will also be reviewed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c96d1fc02534d18d64ddaa0b812d676f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381461,"asset_id":104730363,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381461/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730363"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730363"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730363; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730363]").text(description); $(".js-view-count[data-work-id=104730363]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730363; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730363']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730363, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c96d1fc02534d18d64ddaa0b812d676f" } } $('.js-work-strip[data-work-id=104730363]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730363,"title":"Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches","translated_title":"","metadata":{"abstract":"Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of surviving extremely preterm infants and is associated with significant health care utilization in infancy and beyond. 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Promising future approaches in need of further study will also be reviewed.","publisher":"SAGE Publications","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Clinical Medicine Insights: Pediatrics"},"translated_abstract":"Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of surviving extremely preterm infants and is associated with significant health care utilization in infancy and beyond. Recent advances in neonatal care have resulted in improved survival of extremely low birth weight (ELBW) infants; however, the incidence of BPD has not been substantially impacted by novel interventions in this vulnerable population. The multifactorial cause of BPD requires a multi-pronged approach for prevention and treatment. New approaches in assisted ventilation, optimal nutrition, and pharmacologic interventions are currently being evaluated. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730362"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730362/Adjuvant_Effect_of_Bacille_Calmette_Gu%C3%A9rin_on_Hepatitis_B_Vaccine_Immunogenicity_in_the_Preterm_and_Term_Newborn"><img alt="Research paper thumbnail of Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn" class="work-thumbnail" src="https://attachments.academia-assets.com/104381489/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730362/Adjuvant_Effect_of_Bacille_Calmette_Gu%C3%A9rin_on_Hepatitis_B_Vaccine_Immunogenicity_in_the_Preterm_and_Term_Newborn">Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn</a></div><div class="wp-workCard_item"><span>Frontiers in immunology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Immunization is key to protecting term and preterm infants from a heightened risk of infection. H...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Immunization is key to protecting term and preterm infants from a heightened risk of infection. However, preterm immunity is distinct from that of the term, limiting its ability to effectively respond to vaccines routinely given at birth, such as hepatitis B vaccine (HBV). As part of the Expanded Program on Immunization, HBV is often given together with the live-attenuated vaccine Bacille Calmette-Guérin (BCG), known to activate multiple pattern-recognition receptors. Of note, some clinical studies suggest BCG can enhance efficacy of other vaccines in term newborns. However, little is known about whether BCG can shape Th-polarizing cytokine responses to HBV nor the age-dependency of such effects, including whether they may extend to the preterm. To characterize the effects of BCG on HBV immunogenicity, we studied individual and combined administration of these vaccines to cord newborn and adult human whole blood and mononuclear cellsand to neonatal and adult mice. Compared to either...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="efa79321ee5c69dda3c5759237fd8eb0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381489,"asset_id":104730362,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381489/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730362"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730362"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730362; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730362]").text(description); $(".js-view-count[data-work-id=104730362]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730362; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730362']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730362, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "efa79321ee5c69dda3c5759237fd8eb0" } } $('.js-work-strip[data-work-id=104730362]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730362,"title":"Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn","translated_title":"","metadata":{"abstract":"Immunization is key to protecting term and preterm infants from a heightened risk of infection. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104730361"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104730361/Impaired_Pulmonary_Arterial_Vasoconstriction_and_Nitric_Oxide_Mediated_Relaxation_Underlie_Severe_Pulmonary_Hypertension_in_Sugen_Hypoxia_Rat_Model"><img alt="Research paper thumbnail of Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in Sugen-Hypoxia Rat Model" class="work-thumbnail" src="https://attachments.academia-assets.com/104381484/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730361/Impaired_Pulmonary_Arterial_Vasoconstriction_and_Nitric_Oxide_Mediated_Relaxation_Underlie_Severe_Pulmonary_Hypertension_in_Sugen_Hypoxia_Rat_Model">Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in Sugen-Hypoxia Rat Model</a></div><div class="wp-workCard_item"><span>The Journal of pharmacology and experimental therapeutics</span><span>, Jan 6, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the progn...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and examined the underlying mechanisms, in the sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with sugen (20 mg/kg sc) and exposed to hypoxia (9% O2) for 3 weeks followed by 4 weeks in normoxia (Su/Hx), or treated with sugen alone (Su) or hypoxia alone (Hx) or neither (Nx). After hemodynamic measurements, the heart was assessed for right ventricular hypertrophy (Fulton&#39;s Index), the pulmonary artery, aorta and mesenteric arteries were isolated for vascular function studies, and contractile markers were measured in pulmonary artery using quantitative PCR. Other rats were used for morphometric analysis of pulmonary vascular remodeling. Right ventricular systolic pressure and Fulton&#39;s Index were higher in Su/Hx vs Su, Hx and Nx rats. Pulmonary vascular remode...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e978f6c81e6882a82c6438f862d78b5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381484,"asset_id":104730361,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381484/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730361"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730361"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730361; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730361]").text(description); $(".js-view-count[data-work-id=104730361]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730361; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730361']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730361, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0e978f6c81e6882a82c6438f862d78b5" } } $('.js-work-strip[data-work-id=104730361]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730361,"title":"Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in Sugen-Hypoxia Rat Model","translated_title":"","metadata":{"abstract":"Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and examined the underlying mechanisms, in the sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with sugen (20 mg/kg sc) and exposed to hypoxia (9% O2) for 3 weeks followed by 4 weeks in normoxia (Su/Hx), or treated with sugen alone (Su) or hypoxia alone (Hx) or neither (Nx). After hemodynamic measurements, the heart was assessed for right ventricular hypertrophy (Fulton\u0026#39;s Index), the pulmonary artery, aorta and mesenteric arteries were isolated for vascular function studies, and contractile markers were measured in pulmonary artery using quantitative PCR. Other rats were used for morphometric analysis of pulmonary vascular remodeling. Right ventricular systolic pressure and Fulton\u0026#39;s Index were higher in Su/Hx vs Su, Hx and Nx rats. 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href="https://www.academia.edu/104730359/Cord_Blood_Adipocyte_Fatty_Acid_Binding_Protein_Levels_Correlate_With_Gestational_Age_and_Birth_Weight_in_Neonates"><img alt="Research paper thumbnail of Cord Blood Adipocyte Fatty Acid-Binding Protein Levels Correlate With Gestational Age and Birth Weight in Neonates" class="work-thumbnail" src="https://attachments.academia-assets.com/104381493/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104730359/Cord_Blood_Adipocyte_Fatty_Acid_Binding_Protein_Levels_Correlate_With_Gestational_Age_and_Birth_Weight_in_Neonates">Cord Blood Adipocyte Fatty Acid-Binding Protein Levels Correlate With Gestational Age and Birth Weight in Neonates</a></div><div class="wp-workCard_item"><span>The Journal of clinical endocrinology and metabolism</span><span>, May 1, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Infants born small for gestational age (SGA) have increased risk for obesity and metabolic syndro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Infants born small for gestational age (SGA) have increased risk for obesity and metabolic syndrome, but the underlying mechanisms are not fully elucidated. Adipocyte fatty acid-binding protein (AFABP) is an adipokine that has been implicated in modulation of insulin sensitivity and lipid metabolism. Higher plasma AFABP levels are associated with increased risk of metabolic syndrome and cardiovascular morbidity in adults. Alterations in AFABP levels during fetal growth have not been characterized. To examine AFABP levels in neonatal cord blood in relation to gestational age and birth weight. A cross-sectional study of 361 neonates born at a tertiary academic center. Plasma AFABP levels were measured by enzyme-linked immunosorbent assay. For comparison, venous samples from 26 adults were analyzed. AFABP levels were higher in neonates compared with adults (P &lt; 0.01). Preterm infants had higher AFABP levels [48.2 (31.2 to 73.3) ng/mL] compared with full-term infants [35.8 (25.1 to 5...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0cad319802331f59e376186dc1d8495a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104381493,"asset_id":104730359,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104381493/download_file?st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&st=MTczMjQwOTMyNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104730359"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104730359"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104730359; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104730359]").text(description); $(".js-view-count[data-work-id=104730359]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104730359; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104730359']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104730359, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0cad319802331f59e376186dc1d8495a" } } $('.js-work-strip[data-work-id=104730359]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104730359,"title":"Cord Blood Adipocyte Fatty Acid-Binding Protein Levels Correlate With Gestational Age and Birth Weight in Neonates","translated_title":"","metadata":{"abstract":"Infants born small for gestational age (SGA) have increased risk for obesity and metabolic syndrome, but the underlying mechanisms are not fully elucidated. 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Preterm infants had higher AFABP levels [48.2 (31.2 to 73.3) ng/mL] compared with full-term infants [35.8 (25.1 to 5...","publication_date":{"day":1,"month":5,"year":2017,"errors":{}},"publication_name":"The Journal of clinical endocrinology and metabolism"},"translated_abstract":"Infants born small for gestational age (SGA) have increased risk for obesity and metabolic syndrome, but the underlying mechanisms are not fully elucidated. Adipocyte fatty acid-binding protein (AFABP) is an adipokine that has been implicated in modulation of insulin sensitivity and lipid metabolism. Higher plasma AFABP levels are associated with increased risk of metabolic syndrome and cardiovascular morbidity in adults. Alterations in AFABP levels during fetal growth have not been characterized. To examine AFABP levels in neonatal cord blood in relation to gestational age and birth weight. A cross-sectional study of 361 neonates born at a tertiary academic center. 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