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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Pulmonary Hypertension</h1><div class="u-tcGrayDark">11,433 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Pulmonary Hypertension</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Pulmonary_Hypertension">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27449224 coauthored" data-work_id="27449224" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27449224/Leaflet_area_as_a_determinant_of_tricuspid_regurgitation_severity_in_patients_with_pulmonary_hypertension">Leaflet area as a determinant of tricuspid regurgitation severity in patients with pulmonary hypertension</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Tricuspid regurgitation (TR) is a risk factor for mortality in pulmonary hypertension (PH). TR severity varies among patients with comparable degrees of PH and right ventricular remodeling. The contribution of leaflet adaptation to the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27449224" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Tricuspid regurgitation (TR) is a risk factor for mortality in pulmonary hypertension (PH). TR severity varies among patients with comparable degrees of PH and right ventricular remodeling. The contribution of leaflet adaptation to the pathophysiology of TR has yet to be examined. We hypothesized that tricuspid leaflet area (TLA) is increased in PH, and that the adequacy of this increase relative to right ventricular remodeling determines TR severity. A prospective cohort of 255 patients with PH from pre and postcapillary pathogeneses was assembled from 2 centers. Patients underwent a 3-dimensional echocardiogram focused on the tricuspid apparatus. TLA was measured with the Omni 4D software package. Compared with normal controls, patients with PH had a 2-fold increase in right ventricular volumes, 62% increase in annular area, and 49% increase in TLA. Those with severe TR demonstrated inadequate increase in TLA relative to the closure area, such that the ratio of TLA:closure area &l...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27449224" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d4aa489b5c85cb2dc9a5a2489e56d947" rel="nofollow" data-download="{"attachment_id":47707492,"asset_id":27449224,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47707492/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="51586568" href="https://independent.academia.edu/LanqiHua">Lanqi Hua</a><script data-card-contents-for-user="51586568" type="text/json">{"id":51586568,"first_name":"Lanqi","last_name":"Hua","domain_name":"independent","page_name":"LanqiHua","display_name":"Lanqi Hua","profile_url":"https://independent.academia.edu/LanqiHua?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-27449224">+1</span><div class="hidden js-additional-users-27449224"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/MarkHandschumacher">Mark Handschumacher</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-27449224'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-27449224').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_27449224 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="27449224"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27449224; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27449224]").text(description); $(".js-view-count-work_27449224").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27449224").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27449224"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="53293" rel="nofollow" href="https://www.academia.edu/Documents/in/Software">Software</a>, <script data-card-contents-for-ri="53293" type="text/json">{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="192721" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk_factors">Risk factors</a><script data-card-contents-for-ri="192721" type="text/json">{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27449224]'), work: {"id":27449224,"title":"Leaflet area as a determinant of tricuspid regurgitation severity in patients with pulmonary hypertension","created_at":"2016-08-01T15:59:53.111-07:00","url":"https://www.academia.edu/27449224/Leaflet_area_as_a_determinant_of_tricuspid_regurgitation_severity_in_patients_with_pulmonary_hypertension?f_ri=31958","dom_id":"work_27449224","summary":"Tricuspid regurgitation (TR) is a risk factor for mortality in pulmonary hypertension (PH). TR severity varies among patients with comparable degrees of PH and right ventricular remodeling. The contribution of leaflet adaptation to the pathophysiology of TR has yet to be examined. We hypothesized that tricuspid leaflet area (TLA) is increased in PH, and that the adequacy of this increase relative to right ventricular remodeling determines TR severity. A prospective cohort of 255 patients with PH from pre and postcapillary pathogeneses was assembled from 2 centers. Patients underwent a 3-dimensional echocardiogram focused on the tricuspid apparatus. TLA was measured with the Omni 4D software package. Compared with normal controls, patients with PH had a 2-fold increase in right ventricular volumes, 62% increase in annular area, and 49% increase in TLA. Those with severe TR demonstrated inadequate increase in TLA relative to the closure area, such that the ratio of TLA:closure area \u0026l...","downloadable_attachments":[{"id":47707492,"asset_id":27449224,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":51586568,"first_name":"Lanqi","last_name":"Hua","domain_name":"independent","page_name":"LanqiHua","display_name":"Lanqi Hua","profile_url":"https://independent.academia.edu/LanqiHua?f_ri=31958","photo":"/images/s65_no_pic.png"},{"id":51666062,"first_name":"Mark","last_name":"Handschumacher","domain_name":"independent","page_name":"MarkHandschumacher","display_name":"Mark Handschumacher","profile_url":"https://independent.academia.edu/MarkHandschumacher?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software?f_ri=31958","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=31958","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=31958","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=31958"},{"id":803294,"name":"Ventricular Remodeling","url":"https://www.academia.edu/Documents/in/Ventricular_Remodeling?f_ri=31958"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies?f_ri=31958"},{"id":2463800,"name":"Severity of Illness Index","url":"https://www.academia.edu/Documents/in/Severity_of_Illness_Index?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13112816" data-work_id="13112816" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13112816/Echocardiography_in_Pulmonary_Arterial_Hypertension_from_Diagnosis_to_Prognosis">Echocardiography in Pulmonary Arterial Hypertension: from Diagnosis to Prognosis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Pulmonary arterial hypertension is most often diagnosed in its advanced stages because of the nonspecific nature of early symptoms and signs. Although clinical assessment is essential when evaluating patients with suspected pulmonary... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13112816" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Pulmonary arterial hypertension is most often diagnosed in its advanced stages because of the nonspecific nature of early symptoms and signs. Although clinical assessment is essential when evaluating patients with suspected pulmonary arterial hypertension, echocardiography is a key screening tool in the diagnostic algorithm. It provides an estimate of pulmonary artery pressure, either at rest or during exercise, and is useful in ruling out secondary causes of pulmonary hypertension. In addition, echocardiography is valuable in assessing prognosis and treatment options, monitoring the efficacy of specific therapeutic interventions, and detecting the preclinical stages of disease. (J Am Soc Echocardiogr 2012;-:---.) High CO can be present in hyperkinetic conditions, such as systemic-to-pulmonary shunts (only in the pulmonary circulation), anemia, hyperthyroidism, and so on.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13112816" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8da596550f6761bbffafce1c2c30ea27" rel="nofollow" data-download="{"attachment_id":45655814,"asset_id":13112816,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45655814/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32362914" href="https://unina.academia.edu/AntonioCittadini">Antonio Cittadini</a><script data-card-contents-for-user="32362914" type="text/json">{"id":32362914,"first_name":"Antonio","last_name":"Cittadini","domain_name":"unina","page_name":"AntonioCittadini","display_name":"Antonio Cittadini","profile_url":"https://unina.academia.edu/AntonioCittadini?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13112816 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13112816"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13112816, container: ".js-paper-rank-work_13112816", }); });</script></li><li class="js-percentile-work_13112816 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13112816; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13112816"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13112816 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13112816"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13112816; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13112816]").text(description); $(".js-view-count-work_13112816").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13112816").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13112816"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="8270" rel="nofollow" href="https://www.academia.edu/Documents/in/Forecasting">Forecasting</a>, <script data-card-contents-for-ri="8270" type="text/json">{"id":8270,"name":"Forecasting","url":"https://www.academia.edu/Documents/in/Forecasting?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="46824" rel="nofollow" href="https://www.academia.edu/Documents/in/Echocardiography">Echocardiography</a>, <script data-card-contents-for-ri="46824" type="text/json">{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13112816]'), work: {"id":13112816,"title":"Echocardiography in Pulmonary Arterial Hypertension: from Diagnosis to Prognosis","created_at":"2015-06-19T15:04:30.793-07:00","url":"https://www.academia.edu/13112816/Echocardiography_in_Pulmonary_Arterial_Hypertension_from_Diagnosis_to_Prognosis?f_ri=31958","dom_id":"work_13112816","summary":"Pulmonary arterial hypertension is most often diagnosed in its advanced stages because of the nonspecific nature of early symptoms and signs. Although clinical assessment is essential when evaluating patients with suspected pulmonary arterial hypertension, echocardiography is a key screening tool in the diagnostic algorithm. It provides an estimate of pulmonary artery pressure, either at rest or during exercise, and is useful in ruling out secondary causes of pulmonary hypertension. In addition, echocardiography is valuable in assessing prognosis and treatment options, monitoring the efficacy of specific therapeutic interventions, and detecting the preclinical stages of disease. (J Am Soc Echocardiogr 2012;-:---.) High CO can be present in hyperkinetic conditions, such as systemic-to-pulmonary shunts (only in the pulmonary circulation), anemia, hyperthyroidism, and so on.","downloadable_attachments":[{"id":45655814,"asset_id":13112816,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32362914,"first_name":"Antonio","last_name":"Cittadini","domain_name":"unina","page_name":"AntonioCittadini","display_name":"Antonio Cittadini","profile_url":"https://unina.academia.edu/AntonioCittadini?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":8270,"name":"Forecasting","url":"https://www.academia.edu/Documents/in/Forecasting?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=31958","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958","nofollow":true},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=31958"},{"id":532928,"name":"Chest","url":"https://www.academia.edu/Documents/in/Chest?f_ri=31958"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=31958"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=31958"},{"id":1154249,"name":"Heart Ventricles","url":"https://www.academia.edu/Documents/in/Heart_Ventricles?f_ri=31958"},{"id":2369445,"name":"Pulmonary Artery","url":"https://www.academia.edu/Documents/in/Pulmonary_Artery?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_34362251" data-work_id="34362251" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/34362251/Atrial_Septostomy_in_Patients_with_End_Stage_Pulmonary_Hypertension_No_More_Needles_but_Wires_Energy_and_Close_Anatomical_Definition">Atrial Septostomy in Patients with End-Stage Pulmonary Hypertension. No More Needles but Wires, Energy and Close Anatomical Definition</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To assess the usefulness of a new approach to atrial septal puncture and septostomy in patients with end-stage pulmonary hypertension. Background: Atrial septostomy in end-stage pulmonary hypertension has high mortality and morbidity... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_34362251" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To assess the usefulness of a new approach to atrial septal puncture and septostomy in patients with end-stage pulmonary hypertension. Background: Atrial septostomy in end-stage pulmonary hypertension has high mortality and morbidity rates mainly due to trans-septal catheterization. New approaches to safety during this technical step are expected. Methods: Twelve patients with end-stage pulmonary arterial hypertension (5 males, 7 females, mean age 41, 9 ± 12, 0 years) underwent to balloon atrial septostomy. Intracardiac echography (ICE) was used to localize fossa ovalis while a radiofrequency wire was used to perforate the atrial septum. Then a septostomy was performed by progressive balloon dilatation of atrial septum. Septal perforation was successful at the first attempt in 4 patients and after 5 attempts in a single case, while Bas was successful in all.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/34362251" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6e44daf3417a501f19e51420b39c20e3" rel="nofollow" data-download="{"attachment_id":54252555,"asset_id":34362251,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54252555/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="16268548" href="https://independent.academia.edu/RBaglini">Roberto Baglini</a><script data-card-contents-for-user="16268548" type="text/json">{"id":16268548,"first_name":"Roberto","last_name":"Baglini","domain_name":"independent","page_name":"RBaglini","display_name":"Roberto Baglini","profile_url":"https://independent.academia.edu/RBaglini?f_ri=31958","photo":"https://0.academia-photos.com/16268548/13871560/14948152/s65_roberto.baglini.jpg"}</script></span></span></li><li class="js-paper-rank-work_34362251 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="34362251"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 34362251, container: ".js-paper-rank-work_34362251", }); 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$(".js-view-count[data-work-id=34362251]").text(description); $(".js-view-count-work_34362251").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_34362251").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="34362251"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="29160" rel="nofollow" href="https://www.academia.edu/Documents/in/Interventional_cardiology">Interventional cardiology</a>, <script data-card-contents-for-ri="29160" type="text/json">{"id":29160,"name":"Interventional cardiology","url":"https://www.academia.edu/Documents/in/Interventional_cardiology?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="291048" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiac_Catheterization">Cardiac Catheterization</a>, <script data-card-contents-for-ri="291048" type="text/json">{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="746571" rel="nofollow" href="https://www.academia.edu/Documents/in/Catheter_ablation">Catheter ablation</a><script data-card-contents-for-ri="746571" type="text/json">{"id":746571,"name":"Catheter ablation","url":"https://www.academia.edu/Documents/in/Catheter_ablation?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=34362251]'), work: {"id":34362251,"title":"Atrial Septostomy in Patients with End-Stage Pulmonary Hypertension. No More Needles but Wires, Energy and Close Anatomical Definition","created_at":"2017-08-26T11:24:13.201-07:00","url":"https://www.academia.edu/34362251/Atrial_Septostomy_in_Patients_with_End_Stage_Pulmonary_Hypertension_No_More_Needles_but_Wires_Energy_and_Close_Anatomical_Definition?f_ri=31958","dom_id":"work_34362251","summary":"To assess the usefulness of a new approach to atrial septal puncture and septostomy in patients with end-stage pulmonary hypertension. Background: Atrial septostomy in end-stage pulmonary hypertension has high mortality and morbidity rates mainly due to trans-septal catheterization. New approaches to safety during this technical step are expected. Methods: Twelve patients with end-stage pulmonary arterial hypertension (5 males, 7 females, mean age 41, 9 ± 12, 0 years) underwent to balloon atrial septostomy. Intracardiac echography (ICE) was used to localize fossa ovalis while a radiofrequency wire was used to perforate the atrial septum. Then a septostomy was performed by progressive balloon dilatation of atrial septum. Septal perforation was successful at the first attempt in 4 patients and after 5 attempts in a single case, while Bas was successful in all.","downloadable_attachments":[{"id":54252555,"asset_id":34362251,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":16268548,"first_name":"Roberto","last_name":"Baglini","domain_name":"independent","page_name":"RBaglini","display_name":"Roberto Baglini","profile_url":"https://independent.academia.edu/RBaglini?f_ri=31958","photo":"https://0.academia-photos.com/16268548/13871560/14948152/s65_roberto.baglini.jpg"}],"research_interests":[{"id":29160,"name":"Interventional cardiology","url":"https://www.academia.edu/Documents/in/Interventional_cardiology?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=31958","nofollow":true},{"id":746571,"name":"Catheter ablation","url":"https://www.academia.edu/Documents/in/Catheter_ablation?f_ri=31958","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19609539" data-work_id="19609539" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19609539/Atrial_septal_defect_in_adults_40_years_old_negative_impact_of_low_arterial_oxygen_saturation">Atrial septal defect in adults ≥40 years old: negative impact of low arterial oxygen saturation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Although good prognosis and clinical long-term outcome have been commonly reported in minimally symptomatic adult patients with ASD, this information has been based on studies with a relatively small number of adult patients.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_19609539" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Although good prognosis and clinical long-term outcome have been commonly reported in minimally symptomatic adult patients with ASD, this information has been based on studies with a relatively small number of adult patients. We studied unoperated patients aged over 40 years to define the patterns of presentation, anatomical characteristics, outcome and predictive factors for free-event survival of major cardiovascular and pulmonary events. Methods and results: Two-hundred survivors of atrial septal defect aged over 40-yr attended from 1985 to 1998 were reviewed and followed-up from 1.6 to 22 years. Patients were classified in three groups according to age at entry: Group 1, between 40 and 49; Group 2; 50 and 59; and Group 3, z 60 years old. The mean age at presentation was 48.8 F 9.2 years, and the most common clinical presentations were arrhythmia and dyspnea (51.4%). There were 37 (18.5%) events: 7 heart failure-related, 5 sudden death, 13 severe pulmonary infections, 5 embolisms, and 4 strokes. According to Cox's regression analysis, predictors of primary end point included age group at presentation (hazard ratio 1.71, 95% confidence limits 1.16 to 2.54), and either pulmonary hypertension (mean pulmonary pressure > 35 mmHg; hazard ratio = 0.65 (4.6, confidence limits 2.2 to 9.5) or, arterial oxygen saturation < 80% (hazard ratio 1.71, 95% confidence limits 1.16 to 2.54). Conclusions: This study supports that long term outcome of patients aged >40 years with unoperated ASD is importantly determined by the mPAP (>35 mmHg), SaO2% (_80) and the age at diagnosis. Nevertheless we identified an inverse association between the mPAP level and SaO2% (interaction). The event-free survival expectancy may be estimated using the age at diagnosis and either SaO2% or mPAP. This prognostic stratification based on pathophysiological principles, may help in making decisions for therapeutic interventions. SaO2% should always be measured as a part of the initial clinical approach of those patients with atrial septal defect aged over 40 years. D</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19609539" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8d54c8742185f766a1cd8661f32fd642" rel="nofollow" data-download="{"attachment_id":42072642,"asset_id":19609539,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42072642/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40029084" href="https://unac.academia.edu/CarlosCastellanos">Carlos Castellanos</a><script data-card-contents-for-user="40029084" type="text/json">{"id":40029084,"first_name":"Carlos","last_name":"Castellanos","domain_name":"unac","page_name":"CarlosCastellanos","display_name":"Carlos Castellanos","profile_url":"https://unac.academia.edu/CarlosCastellanos?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_19609539 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19609539"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 19609539, container: ".js-paper-rank-work_19609539", }); 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$(".js-view-count[data-work-id=19609539]").text(description); $(".js-view-count-work_19609539").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_19609539").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="19609539"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">27</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" rel="nofollow" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="25436" rel="nofollow" href="https://www.academia.edu/Documents/in/Stratification">Stratification</a>, <script data-card-contents-for-ri="25436" type="text/json">{"id":25436,"name":"Stratification","url":"https://www.academia.edu/Documents/in/Stratification?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a><script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=19609539]'), work: {"id":19609539,"title":"Atrial septal defect in adults ≥40 years old: negative impact of low arterial oxygen saturation","created_at":"2015-12-11T08:47:06.586-08:00","url":"https://www.academia.edu/19609539/Atrial_septal_defect_in_adults_40_years_old_negative_impact_of_low_arterial_oxygen_saturation?f_ri=31958","dom_id":"work_19609539","summary":"Background: Although good prognosis and clinical long-term outcome have been commonly reported in minimally symptomatic adult patients with ASD, this information has been based on studies with a relatively small number of adult patients. We studied unoperated patients aged over 40 years to define the patterns of presentation, anatomical characteristics, outcome and predictive factors for free-event survival of major cardiovascular and pulmonary events. Methods and results: Two-hundred survivors of atrial septal defect aged over 40-yr attended from 1985 to 1998 were reviewed and followed-up from 1.6 to 22 years. Patients were classified in three groups according to age at entry: Group 1, between 40 and 49; Group 2; 50 and 59; and Group 3, z 60 years old. The mean age at presentation was 48.8 F 9.2 years, and the most common clinical presentations were arrhythmia and dyspnea (51.4%). There were 37 (18.5%) events: 7 heart failure-related, 5 sudden death, 13 severe pulmonary infections, 5 embolisms, and 4 strokes. According to Cox's regression analysis, predictors of primary end point included age group at presentation (hazard ratio 1.71, 95% confidence limits 1.16 to 2.54), and either pulmonary hypertension (mean pulmonary pressure \u003e 35 mmHg; hazard ratio = 0.65 (4.6, confidence limits 2.2 to 9.5) or, arterial oxygen saturation \u003c 80% (hazard ratio 1.71, 95% confidence limits 1.16 to 2.54). Conclusions: This study supports that long term outcome of patients aged \u003e40 years with unoperated ASD is importantly determined by the mPAP (\u003e35 mmHg), SaO2% (_80) and the age at diagnosis. Nevertheless we identified an inverse association between the mPAP level and SaO2% (interaction). The event-free survival expectancy may be estimated using the age at diagnosis and either SaO2% or mPAP. This prognostic stratification based on pathophysiological principles, may help in making decisions for therapeutic interventions. SaO2% should always be measured as a part of the initial clinical approach of those patients with atrial septal defect aged over 40 years. D","downloadable_attachments":[{"id":42072642,"asset_id":19609539,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":40029084,"first_name":"Carlos","last_name":"Castellanos","domain_name":"unac","page_name":"CarlosCastellanos","display_name":"Carlos Castellanos","profile_url":"https://unac.academia.edu/CarlosCastellanos?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=31958","nofollow":true},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=31958","nofollow":true},{"id":25436,"name":"Stratification","url":"https://www.academia.edu/Documents/in/Stratification?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=31958"},{"id":59748,"name":"Sudden Death","url":"https://www.academia.edu/Documents/in/Sudden_Death?f_ri=31958"},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=31958"},{"id":123230,"name":"Regression Analysis","url":"https://www.academia.edu/Documents/in/Regression_Analysis?f_ri=31958"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=31958"},{"id":164831,"name":"Dyspnea","url":"https://www.academia.edu/Documents/in/Dyspnea?f_ri=31958"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=31958"},{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=31958"},{"id":323090,"name":"Cardiac Arrhythmias","url":"https://www.academia.edu/Documents/in/Cardiac_Arrhythmias?f_ri=31958"},{"id":380825,"name":"Oxygen","url":"https://www.academia.edu/Documents/in/Oxygen?f_ri=31958"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=31958"},{"id":487159,"name":"Group","url":"https://www.academia.edu/Documents/in/Group?f_ri=31958"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=31958"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=31958"},{"id":735030,"name":"Congenital Heart Disease","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Disease?f_ri=31958"},{"id":746681,"name":"Arrhythmia","url":"https://www.academia.edu/Documents/in/Arrhythmia?f_ri=31958"},{"id":985062,"name":"Clinical Presentation","url":"https://www.academia.edu/Documents/in/Clinical_Presentation?f_ri=31958"},{"id":1228884,"name":"Confidence Limit","url":"https://www.academia.edu/Documents/in/Confidence_Limit?f_ri=31958"},{"id":1272981,"name":"Proportional Hazards Models","url":"https://www.academia.edu/Documents/in/Proportional_Hazards_Models?f_ri=31958"},{"id":1325909,"name":"Atrial Septal Defect","url":"https://www.academia.edu/Documents/in/Atrial_Septal_Defect?f_ri=31958"},{"id":1470936,"name":"Age Groups","url":"https://www.academia.edu/Documents/in/Age_Groups?f_ri=31958"},{"id":1558342,"name":"Oxygen saturation","url":"https://www.academia.edu/Documents/in/Oxygen_saturation?f_ri=31958"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_66555046" data-work_id="66555046" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/66555046/The_Cambridge_Pulmonary_Hypertension_Outcome_Review_CAMPHOR_a_measure_of_health_related_quality_of_life_and_quality_of_life_for_patients_with_pulmonary_hypertension">The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR): a measure of health-related quality of life and quality of life for patients with pulmonary hypertension</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: No outcome measures specific to pulmonary hypertension (PH) currently exist. The aim of the study was to develop health-related quality of life (symptoms and functioning) scales and a quality of life scale that would allow... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_66555046" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: No outcome measures specific to pulmonary hypertension (PH) currently exist. The aim of the study was to develop health-related quality of life (symptoms and functioning) scales and a quality of life scale that would allow comprehensive, accurate and valid patient-reported outcome assessment in clinical studies. Methods: The content of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) was derived from qualitative interviews conducted with 35 patients. Item reduction was based on the analysis of responses to a postal survey (n=75) and patient interviews (n=15) designed to determine face and content validity. A final postal validation study (n=91) was performed to determine reproducibility and construct validity. Results: The questionnaire was well received by participants who found it to be relevant, comprehensible and quick and easy to complete. Rasch and factor analyses were conducted to ensure unidimensionality of the final CAMPHOR scales; Overall symptoms (made up of Energy, Breathlessness and Mood subscales), Functioning and Quality of life. The CAMPHOR scales had good internal consistency (a=0.90-0.92) and reproducibility (test-retest correlations=0.86-0.92). They also exhibited convergent, divergent and known groups validity. Conclusions: The CAMPHOR is a valuable new instrument for assessing patient-reported outcome in PH clinical trials and routine practice.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/66555046" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d4e686fce5b77c6f91d7ef4a1f33bf26" rel="nofollow" data-download="{"attachment_id":77701164,"asset_id":66555046,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77701164/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="55334260" href="https://independent.academia.edu/StephenMcKenna6">Stephen McKenna</a><script data-card-contents-for-user="55334260" type="text/json">{"id":55334260,"first_name":"Stephen","last_name":"McKenna","domain_name":"independent","page_name":"StephenMcKenna6","display_name":"Stephen McKenna","profile_url":"https://independent.academia.edu/StephenMcKenna6?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_66555046 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="66555046"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 66555046, container: ".js-paper-rank-work_66555046", }); });</script></li><li class="js-percentile-work_66555046 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66555046; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_66555046"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_66555046 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="66555046"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66555046; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66555046]").text(description); $(".js-view-count-work_66555046").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_66555046").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="66555046"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2599" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychometrics">Psychometrics</a>, <script data-card-contents-for-ri="2599" type="text/json">{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4531" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Trial">Clinical Trial</a>, <script data-card-contents-for-ri="4531" type="text/json">{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7470" rel="nofollow" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=66555046]'), work: {"id":66555046,"title":"The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR): a measure of health-related quality of life and quality of life for patients with pulmonary hypertension","created_at":"2021-12-30T05:34:48.721-08:00","url":"https://www.academia.edu/66555046/The_Cambridge_Pulmonary_Hypertension_Outcome_Review_CAMPHOR_a_measure_of_health_related_quality_of_life_and_quality_of_life_for_patients_with_pulmonary_hypertension?f_ri=31958","dom_id":"work_66555046","summary":"Objective: No outcome measures specific to pulmonary hypertension (PH) currently exist. The aim of the study was to develop health-related quality of life (symptoms and functioning) scales and a quality of life scale that would allow comprehensive, accurate and valid patient-reported outcome assessment in clinical studies. Methods: The content of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) was derived from qualitative interviews conducted with 35 patients. Item reduction was based on the analysis of responses to a postal survey (n=75) and patient interviews (n=15) designed to determine face and content validity. A final postal validation study (n=91) was performed to determine reproducibility and construct validity. Results: The questionnaire was well received by participants who found it to be relevant, comprehensible and quick and easy to complete. Rasch and factor analyses were conducted to ensure unidimensionality of the final CAMPHOR scales; Overall symptoms (made up of Energy, Breathlessness and Mood subscales), Functioning and Quality of life. The CAMPHOR scales had good internal consistency (a=0.90-0.92) and reproducibility (test-retest correlations=0.86-0.92). They also exhibited convergent, divergent and known groups validity. Conclusions: The CAMPHOR is a valuable new instrument for assessing patient-reported outcome in PH clinical trials and routine practice.","downloadable_attachments":[{"id":77701164,"asset_id":66555046,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":55334260,"first_name":"Stephen","last_name":"McKenna","domain_name":"independent","page_name":"StephenMcKenna6","display_name":"Stephen McKenna","profile_url":"https://independent.academia.edu/StephenMcKenna6?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=31958","nofollow":true},{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=31958","nofollow":true},{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=31958","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=31958","nofollow":true},{"id":30494,"name":"England","url":"https://www.academia.edu/Documents/in/England?f_ri=31958"},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958"},{"id":44529,"name":"Activities of Daily Living","url":"https://www.academia.edu/Documents/in/Activities_of_Daily_Living?f_ri=31958"},{"id":82844,"name":"Health related Quality of Life","url":"https://www.academia.edu/Documents/in/Health_related_Quality_of_Life?f_ri=31958"},{"id":104434,"name":"Construct Validity","url":"https://www.academia.edu/Documents/in/Construct_Validity?f_ri=31958"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=31958"},{"id":291274,"name":"Great Britain","url":"https://www.academia.edu/Documents/in/Great_Britain?f_ri=31958"},{"id":546356,"name":"Clinical Study","url":"https://www.academia.edu/Documents/in/Clinical_Study?f_ri=31958"},{"id":842184,"name":"Quality Life","url":"https://www.academia.edu/Documents/in/Quality_Life?f_ri=31958"},{"id":2529977,"name":"attitude to health","url":"https://www.academia.edu/Documents/in/attitude_to_health?f_ri=31958"},{"id":2592746,"name":"Outcome measure","url":"https://www.academia.edu/Documents/in/Outcome_measure?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_55410380" data-work_id="55410380" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/55410380/124_Severe_Pulmonary_Hypertension_in_IPF_Characteristics_and_Implications">124: Severe Pulmonary Hypertension in IPF: Characteristics and Implications</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Between 3/2006 and 9/2007 2951 pts met inclusion criteria and had followup data. Lw pts tended to be younger at diagnosis than Iw or Hw pts (mean age 46 vs.52 and 53 yrs respectively) with a trend to more FCIV pts in Iw and Hw. Survival... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_55410380" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Between 3/2006 and 9/2007 2951 pts met inclusion criteria and had followup data. Lw pts tended to be younger at diagnosis than Iw or Hw pts (mean age 46 vs.52 and 53 yrs respectively) with a trend to more FCIV pts in Iw and Hw. Survival and freedom from hospitalization was the same in all groups. Enrollment 6MWD tended to be lower in Iw and Hw without significant difference in the frequency or degree of improvement in 6MWD at one year. Repeat RHC done in 1272 patients demonstrated that PAOP values normalized (Յ 12) in 50-65% of Iw and Hw patients and worsened in 21% of the previously Lw pts. Conclusions: There was no difference in survival or hospitalization between classical PAH pts and those with higher left sided pressures. The latter pts tended to be slightly older at diagnosis with slightly worse 6MWD at both enrollment and follow up at 12 months. The majority of patients outside the classical PAH definition at diagnosis had hemodynamcis in the classical range after treatment. Similar outcomes in all groups suggests that PAH diagnosis and PH specific therapy were appropriate in this expanded population.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/55410380" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dfd44ae9b16b93826908c9f590808d2a" rel="nofollow" data-download="{"attachment_id":71292955,"asset_id":55410380,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/71292955/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38212303" href="https://independent.academia.edu/LucyThuita">Lucy Thuita</a><script data-card-contents-for-user="38212303" type="text/json">{"id":38212303,"first_name":"Lucy","last_name":"Thuita","domain_name":"independent","page_name":"LucyThuita","display_name":"Lucy Thuita","profile_url":"https://independent.academia.edu/LucyThuita?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_55410380 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="55410380"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 55410380, container: ".js-paper-rank-work_55410380", }); });</script></li><li class="js-percentile-work_55410380 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55410380; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_55410380"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_55410380 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="55410380"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55410380; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55410380]").text(description); $(".js-view-count-work_55410380").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_55410380").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="55410380"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1036494" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation">Heart and Lung Transplantation</a>, <script data-card-contents-for-ri="1036494" type="text/json">{"id":1036494,"name":"Heart and Lung Transplantation","url":"https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3789879" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology">Cardiovascular medicine and haematology</a><script data-card-contents-for-ri="3789879" type="text/json">{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=55410380]'), work: {"id":55410380,"title":"124: Severe Pulmonary Hypertension in IPF: Characteristics and Implications","created_at":"2021-10-04T05:00:11.992-07:00","url":"https://www.academia.edu/55410380/124_Severe_Pulmonary_Hypertension_in_IPF_Characteristics_and_Implications?f_ri=31958","dom_id":"work_55410380","summary":"Between 3/2006 and 9/2007 2951 pts met inclusion criteria and had followup data. Lw pts tended to be younger at diagnosis than Iw or Hw pts (mean age 46 vs.52 and 53 yrs respectively) with a trend to more FCIV pts in Iw and Hw. Survival and freedom from hospitalization was the same in all groups. Enrollment 6MWD tended to be lower in Iw and Hw without significant difference in the frequency or degree of improvement in 6MWD at one year. Repeat RHC done in 1272 patients demonstrated that PAOP values normalized (Յ 12) in 50-65% of Iw and Hw patients and worsened in 21% of the previously Lw pts. Conclusions: There was no difference in survival or hospitalization between classical PAH pts and those with higher left sided pressures. The latter pts tended to be slightly older at diagnosis with slightly worse 6MWD at both enrollment and follow up at 12 months. The majority of patients outside the classical PAH definition at diagnosis had hemodynamcis in the classical range after treatment. Similar outcomes in all groups suggests that PAH diagnosis and PH specific therapy were appropriate in this expanded population.","downloadable_attachments":[{"id":71292955,"asset_id":55410380,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38212303,"first_name":"Lucy","last_name":"Thuita","domain_name":"independent","page_name":"LucyThuita","display_name":"Lucy Thuita","profile_url":"https://independent.academia.edu/LucyThuita?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":1036494,"name":"Heart and Lung Transplantation","url":"https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation?f_ri=31958","nofollow":true},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=31958","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_46959875" data-work_id="46959875" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/46959875/Platelet_protease_activated_receptor_1_and_membrane_expression_of_P_selectin_in_pulmonary_arterial_hypertension">Platelet protease-activated receptor 1 and membrane expression of P-selectin in pulmonary arterial hypertension</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Introduction: Pulmonary arterial hypertension (PAH) is frequently associated with thrombotic events, particularly involving the pulmonary microcirculation at sites of vascular injury. We therefore decided to analyse protease-activated... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_46959875" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Introduction: Pulmonary arterial hypertension (PAH) is frequently associated with thrombotic events, particularly involving the pulmonary microcirculation at sites of vascular injury. We therefore decided to analyse protease-activated receptor 1 (PAR1), a key element in the activation of human platelets by thrombin, in PAH patients in stable clinical condition. Methods: Using flow cytometry, we analyzed platelet PAR1 density, PAR1-mediated exposure of P-selectin and the formation of platelet-leukocyte aggregates in 30 PAH patients aged 11 to 78 years (median 50.5 years). The control group consisted of 25 healthy subjects with the same age range as patients. Results: In patients, total platelet PAR1 density and uncleaved PAR1 density correlated negatively with platelet count (r 2 = 0.33 and r 2 = 0.34 respectively, p b 0.0015). In patients with a low platelet count (b 150 × 10 9 platelets/L), both densities were increased relative to controls (82% and 33% respectively, p b 0.05). Thrombin peptide-induced platelet exposure of P-selectin was directly related to total and uncleaved PAR1 density (respectively, r 2 = 0.33 and r 2 = 0.29, p b 0.0025) and increased in subjects with low platelet count (46% versus those with normal platelet count, p b 0.05). Patients with low platelet count had decreased in vitro thrombin-induced formation of platelet-leukocyte aggregates (57% decrease versus controls, p b 0.05). Conclusions: There seems to be a subpopulation of PAH patients with increased propensity to thrombotic events as suggested by increased platelet PAR1 expression and PAR-mediated surface exposure of P-selectin associated with decreased platelet count.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/46959875" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8764af9445f6e94949ed3988f7ec4715" rel="nofollow" data-download="{"attachment_id":66309146,"asset_id":46959875,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/66309146/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12568411" href="https://usp-br1.academia.edu/SergioBydlowski">Sergio Bydlowski</a><script data-card-contents-for-user="12568411" type="text/json">{"id":12568411,"first_name":"Sergio","last_name":"Bydlowski","domain_name":"usp-br1","page_name":"SergioBydlowski","display_name":"Sergio Bydlowski","profile_url":"https://usp-br1.academia.edu/SergioBydlowski?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_46959875 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="46959875"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 46959875, container: ".js-paper-rank-work_46959875", }); });</script></li><li class="js-percentile-work_46959875 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 46959875; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_46959875"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_46959875 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="46959875"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 46959875; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=46959875]").text(description); $(".js-view-count-work_46959875").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_46959875").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="46959875"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22997" rel="nofollow" href="https://www.academia.edu/Documents/in/Arterial_hypertension">Arterial hypertension</a>, <script data-card-contents-for-ri="22997" type="text/json">{"id":22997,"name":"Arterial hypertension","url":"https://www.academia.edu/Documents/in/Arterial_hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52136" rel="nofollow" href="https://www.academia.edu/Documents/in/Platelet">Platelet</a><script data-card-contents-for-ri="52136" type="text/json">{"id":52136,"name":"Platelet","url":"https://www.academia.edu/Documents/in/Platelet?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=46959875]'), work: {"id":46959875,"title":"Platelet protease-activated receptor 1 and membrane expression of P-selectin in pulmonary arterial hypertension","created_at":"2021-04-20T01:04:59.889-07:00","url":"https://www.academia.edu/46959875/Platelet_protease_activated_receptor_1_and_membrane_expression_of_P_selectin_in_pulmonary_arterial_hypertension?f_ri=31958","dom_id":"work_46959875","summary":"Introduction: Pulmonary arterial hypertension (PAH) is frequently associated with thrombotic events, particularly involving the pulmonary microcirculation at sites of vascular injury. We therefore decided to analyse protease-activated receptor 1 (PAR1), a key element in the activation of human platelets by thrombin, in PAH patients in stable clinical condition. Methods: Using flow cytometry, we analyzed platelet PAR1 density, PAR1-mediated exposure of P-selectin and the formation of platelet-leukocyte aggregates in 30 PAH patients aged 11 to 78 years (median 50.5 years). The control group consisted of 25 healthy subjects with the same age range as patients. Results: In patients, total platelet PAR1 density and uncleaved PAR1 density correlated negatively with platelet count (r 2 = 0.33 and r 2 = 0.34 respectively, p b 0.0015). In patients with a low platelet count (b 150 × 10 9 platelets/L), both densities were increased relative to controls (82% and 33% respectively, p b 0.05). Thrombin peptide-induced platelet exposure of P-selectin was directly related to total and uncleaved PAR1 density (respectively, r 2 = 0.33 and r 2 = 0.29, p b 0.0025) and increased in subjects with low platelet count (46% versus those with normal platelet count, p b 0.05). Patients with low platelet count had decreased in vitro thrombin-induced formation of platelet-leukocyte aggregates (57% decrease versus controls, p b 0.05). Conclusions: There seems to be a subpopulation of PAH patients with increased propensity to thrombotic events as suggested by increased platelet PAR1 expression and PAR-mediated surface exposure of P-selectin associated with decreased platelet count.","downloadable_attachments":[{"id":66309146,"asset_id":46959875,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":12568411,"first_name":"Sergio","last_name":"Bydlowski","domain_name":"usp-br1","page_name":"SergioBydlowski","display_name":"Sergio Bydlowski","profile_url":"https://usp-br1.academia.edu/SergioBydlowski?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true},{"id":22997,"name":"Arterial hypertension","url":"https://www.academia.edu/Documents/in/Arterial_hypertension?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":52136,"name":"Platelet","url":"https://www.academia.edu/Documents/in/Platelet?f_ri=31958","nofollow":true},{"id":62996,"name":"Par","url":"https://www.academia.edu/Documents/in/Par?f_ri=31958"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=31958"},{"id":205694,"name":"TRAP","url":"https://www.academia.edu/Documents/in/TRAP?f_ri=31958"},{"id":209508,"name":"Platelet activation mechanism","url":"https://www.academia.edu/Documents/in/Platelet_activation_mechanism?f_ri=31958"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":496063,"name":"Thrombosis","url":"https://www.academia.edu/Documents/in/Thrombosis?f_ri=31958"},{"id":1110464,"name":"Vascular Injury","url":"https://www.academia.edu/Documents/in/Vascular_Injury?f_ri=31958"},{"id":1281380,"name":"Platelet Count","url":"https://www.academia.edu/Documents/in/Platelet_Count?f_ri=31958"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies?f_ri=31958"},{"id":2369445,"name":"Pulmonary Artery","url":"https://www.academia.edu/Documents/in/Pulmonary_Artery?f_ri=31958"},{"id":3187114,"name":"Blood platelets","url":"https://www.academia.edu/Documents/in/Blood_platelets?f_ri=31958"},{"id":3514584,"name":"Pulmonary artery hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_artery_hypertension?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_36739097" data-work_id="36739097" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/36739097/Bidirectional_shunt_in_uncomplicated_atrial_septal_defect">Bidirectional shunt in uncomplicated atrial septal defect</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The presence of right to left shunts at atrial level in 40 patients with an uncomplicated atrial septal defect was determined by measuring the pulmonary vein to systemic artery oxygen stepdown. In six patients (group 1) a sizeable right... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_36739097" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The presence of right to left shunts at atrial level in 40 patients with an uncomplicated atrial septal defect was determined by measuring the pulmonary vein to systemic artery oxygen stepdown. In six patients (group 1) a sizeable right to left shunt was found: left atrial oxygen stepdown was >0 7 vol%, mean right to left shunt 0-67 1/min/m2 (range 0.361-0), and arterial oxygen saturation between 84% and 90.5%. The patients in group 1 did not show any differences from those with left to right shunts alone (group 2) as regards sex, cardiac rhythm, heart rate, "a" wave and mean right atrial pressure, end diastolic right ventricular pressure, morphology of diastolic right ventricular pressure curves, pulmonary to systemic vascular resistance ratio, size of the defect, and coexistence of anomalous pulmonary venous drainage. Patients with coexisting right to left shunts were, however, significantly older and had smaller left to right shunts.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/36739097" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="96590e5e88d49a605aa73bad65c7dfe8" rel="nofollow" data-download="{"attachment_id":56682269,"asset_id":36739097,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/56682269/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="64787511" href="https://independent.academia.edu/JuanAngel63">Juan Angel</a><script data-card-contents-for-user="64787511" type="text/json">{"id":64787511,"first_name":"Juan","last_name":"Angel","domain_name":"independent","page_name":"JuanAngel63","display_name":"Juan Angel","profile_url":"https://independent.academia.edu/JuanAngel63?f_ri=31958","photo":"https://0.academia-photos.com/64787511/34318770/30213250/s65_juan.angel.jpg"}</script></span></span></li><li class="js-paper-rank-work_36739097 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="36739097"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 36739097, container: ".js-paper-rank-work_36739097", }); });</script></li><li class="js-percentile-work_36739097 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 36739097; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_36739097"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_36739097 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="36739097"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 36739097; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=36739097]").text(description); $(".js-view-count-work_36739097").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_36739097").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="36739097"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" rel="nofollow" href="https://www.academia.edu/Documents/in/Child">Child</a><script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=36739097]'), work: {"id":36739097,"title":"Bidirectional shunt in uncomplicated atrial septal defect","created_at":"2018-05-29T04:56:33.224-07:00","url":"https://www.academia.edu/36739097/Bidirectional_shunt_in_uncomplicated_atrial_septal_defect?f_ri=31958","dom_id":"work_36739097","summary":"The presence of right to left shunts at atrial level in 40 patients with an uncomplicated atrial septal defect was determined by measuring the pulmonary vein to systemic artery oxygen stepdown. In six patients (group 1) a sizeable right to left shunt was found: left atrial oxygen stepdown was \u003e0 7 vol%, mean right to left shunt 0-67 1/min/m2 (range 0.361-0), and arterial oxygen saturation between 84% and 90.5%. The patients in group 1 did not show any differences from those with left to right shunts alone (group 2) as regards sex, cardiac rhythm, heart rate, \"a\" wave and mean right atrial pressure, end diastolic right ventricular pressure, morphology of diastolic right ventricular pressure curves, pulmonary to systemic vascular resistance ratio, size of the defect, and coexistence of anomalous pulmonary venous drainage. Patients with coexisting right to left shunts were, however, significantly older and had smaller left to right shunts.","downloadable_attachments":[{"id":56682269,"asset_id":36739097,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":64787511,"first_name":"Juan","last_name":"Angel","domain_name":"independent","page_name":"JuanAngel63","display_name":"Juan Angel","profile_url":"https://independent.academia.edu/JuanAngel63?f_ri=31958","photo":"https://0.academia-photos.com/64787511/34318770/30213250/s65_juan.angel.jpg"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=31958","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=31958","nofollow":true},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=31958"},{"id":131298,"name":"Heart rate","url":"https://www.academia.edu/Documents/in/Heart_rate?f_ri=31958"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=31958"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=31958"},{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=31958"},{"id":380825,"name":"Oxygen","url":"https://www.academia.edu/Documents/in/Oxygen?f_ri=31958"},{"id":487159,"name":"Group","url":"https://www.academia.edu/Documents/in/Group?f_ri=31958"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=31958"},{"id":1325909,"name":"Atrial Septal Defect","url":"https://www.academia.edu/Documents/in/Atrial_Septal_Defect?f_ri=31958"},{"id":1558342,"name":"Oxygen saturation","url":"https://www.academia.edu/Documents/in/Oxygen_saturation?f_ri=31958"},{"id":1969879,"name":"Vascular Resistance","url":"https://www.academia.edu/Documents/in/Vascular_Resistance?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_35676041" data-work_id="35676041" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/35676041/Pulmonary_Capillary_Endothelium_Bound_Angiotensin_Converting_Enzyme_Activity_in_Humans">Pulmonary Capillary Endothelium-Bound Angiotensin-Converting Enzyme Activity in Humans</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background-Pulmonary endothelium has metabolic functions including the conversion of angiotensin I to angiotensin II by angiotensin-converting ectoenzyme (ACE). In this study, we have validated an indicator-dilution technique that... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_35676041" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background-Pulmonary endothelium has metabolic functions including the conversion of angiotensin I to angiotensin II by angiotensin-converting ectoenzyme (ACE). In this study, we have validated an indicator-dilution technique that provides estimations of dynamically perfused capillary surface area (DPCSA) in humans, and we have characterized pulmonary endothelial ACE in vivo. Methods and Results-In 12 adults, single-pass transpulmonary (one or both lungs) hydrolysis of the specific ACE substrate 3 H-benzoyl-Phe-Ala-Pro ( 3 H-BPAP) was measured and expressed as % metabolism (%M) and vϭϪln(1ϪM). We also calculated A max /K m , an index of DPCSA. %M (70.1Ϯ3.2 vs 67.9Ϯ3.1) and v (1.29Ϯ0.14 vs 1.20Ϯ0.12) were similar in both lungs and the right lung, respectively, whereas A max /K m/ /body surface area decreased from 2460Ϯ193 to 1318Ϯ115 mL/min per square meter. Conclusions-Pulmonary endothelial ACE activity can be assessed in humans at the bedside by means of indicatordilution techniques. Our data suggest homogeneous pulmonary capillary ACE concentrations and capillary transit times (t c ) in both human lungs, and similar t c within the normal range of cardiac index. A max /K m in the right lung is 54% of total A max /K m in both lungs, suggesting that A max /K m is a reliable and quantifiable index of DPCSA in humans. (Circulation. 1999;99:1593-1599.)</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/35676041" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="29d9e59d28c287452f1328ec7e276cad" rel="nofollow" data-download="{"attachment_id":55546544,"asset_id":35676041,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/55546544/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="31679598" href="https://uoa.academia.edu/ApostolosArmaganidis">Apostolos Armaganidis</a><script data-card-contents-for-user="31679598" type="text/json">{"id":31679598,"first_name":"Apostolos","last_name":"Armaganidis","domain_name":"uoa","page_name":"ApostolosArmaganidis","display_name":"Apostolos Armaganidis","profile_url":"https://uoa.academia.edu/ApostolosArmaganidis?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_35676041 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="35676041"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 35676041, container: ".js-paper-rank-work_35676041", }); 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$(".js-view-count[data-work-id=35676041]").text(description); $(".js-view-count-work_35676041").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_35676041").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="35676041"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="71421" rel="nofollow" href="https://www.academia.edu/Documents/in/Capillaries">Capillaries</a>, <script data-card-contents-for-ri="71421" type="text/json">{"id":71421,"name":"Capillaries","url":"https://www.academia.edu/Documents/in/Capillaries?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="74347" rel="nofollow" href="https://www.academia.edu/Documents/in/Hemodynamics">Hemodynamics</a><script data-card-contents-for-ri="74347" type="text/json">{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=35676041]'), work: {"id":35676041,"title":"Pulmonary Capillary Endothelium-Bound Angiotensin-Converting Enzyme Activity in Humans","created_at":"2018-01-15T14:14:43.127-08:00","url":"https://www.academia.edu/35676041/Pulmonary_Capillary_Endothelium_Bound_Angiotensin_Converting_Enzyme_Activity_in_Humans?f_ri=31958","dom_id":"work_35676041","summary":"Background-Pulmonary endothelium has metabolic functions including the conversion of angiotensin I to angiotensin II by angiotensin-converting ectoenzyme (ACE). In this study, we have validated an indicator-dilution technique that provides estimations of dynamically perfused capillary surface area (DPCSA) in humans, and we have characterized pulmonary endothelial ACE in vivo. Methods and Results-In 12 adults, single-pass transpulmonary (one or both lungs) hydrolysis of the specific ACE substrate 3 H-benzoyl-Phe-Ala-Pro ( 3 H-BPAP) was measured and expressed as % metabolism (%M) and vϭϪln(1ϪM). We also calculated A max /K m , an index of DPCSA. %M (70.1Ϯ3.2 vs 67.9Ϯ3.1) and v (1.29Ϯ0.14 vs 1.20Ϯ0.12) were similar in both lungs and the right lung, respectively, whereas A max /K m/ /body surface area decreased from 2460Ϯ193 to 1318Ϯ115 mL/min per square meter. Conclusions-Pulmonary endothelial ACE activity can be assessed in humans at the bedside by means of indicatordilution techniques. Our data suggest homogeneous pulmonary capillary ACE concentrations and capillary transit times (t c ) in both human lungs, and similar t c within the normal range of cardiac index. A max /K m in the right lung is 54% of total A max /K m in both lungs, suggesting that A max /K m is a reliable and quantifiable index of DPCSA in humans. (Circulation. 1999;99:1593-1599.)","downloadable_attachments":[{"id":55546544,"asset_id":35676041,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":31679598,"first_name":"Apostolos","last_name":"Armaganidis","domain_name":"uoa","page_name":"ApostolosArmaganidis","display_name":"Apostolos Armaganidis","profile_url":"https://uoa.academia.edu/ApostolosArmaganidis?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":71421,"name":"Capillaries","url":"https://www.academia.edu/Documents/in/Capillaries?f_ri=31958","nofollow":true},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=31958","nofollow":true},{"id":138877,"name":"Vascular endothelium","url":"https://www.academia.edu/Documents/in/Vascular_endothelium?f_ri=31958"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung?f_ri=31958"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=31958"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=31958"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=31958"},{"id":440014,"name":"Tritium","url":"https://www.academia.edu/Documents/in/Tritium?f_ri=31958"},{"id":515070,"name":"Circulation","url":"https://www.academia.edu/Documents/in/Circulation?f_ri=31958"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=31958"},{"id":876966,"name":"Blood gas analysis","url":"https://www.academia.edu/Documents/in/Blood_gas_analysis?f_ri=31958"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=31958"},{"id":2226523,"name":"Pulmonary circulation","url":"https://www.academia.edu/Documents/in/Pulmonary_circulation?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10307602" data-work_id="10307602" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10307602/Pharmacokinetics_safety_and_efficacy_of_bosentan_in_pediatric_patients_with_pulmonary_arterial_hypertension">Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Bosentan, a dual endothelin-receptor antagonist, is registered for the treatment of pulmonary arterial hypertension. Little is known about the effects of bosentan in children. This study was conducted to investigate the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10307602" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Bosentan, a dual endothelin-receptor antagonist, is registered for the treatment of pulmonary arterial hypertension. Little is known about the effects of bosentan in children. This study was conducted to investigate the pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension. Methods: In this 2-center, open-label study, 19 pediatric patients with pulmonary arterial hypertension were enrolled and stratified for body weight and epoprostenol use. Patients weighing between 10 and 20 kg, between 20 and 40 kg, or greater than 40 kg received a single dose of 31.25, 62.5, or 125 mg, respectively, on day 1, followed by 4 weeks of treatment with the initial dose. The dose was then up-titrated to the target dose (31.25, 62.5, or 125 mg twice daily). Pharmacokinetic and hemodynamic parameters were obtained at baseline and after 12 weeks of treatment. Six-minute walk distance and cardiopulmonary exercise testing results were measured at baseline and at week 12 in children aged 8 years or older. Results: The variability in exposure among the 3 groups was less than 2-fold after single-and multiple-dose administration. The exposure to bosentan decreased over time in all groups. The covariates body weight, gender, age, and the use of epoprostenol had no significant effect on the pharmacokinetics of bosentan. Bosentan produced hemodynamic improvement and was well tolerated. The mean change from baseline in mean pulmonary artery pressure was ؊8.0 mm Hg (95% confidence interval, ؊12.2 to ؊3.7 mm Hg), and that in pulmonary vascular resistance index was ؊300 dyne · s · m 2 /cm 5 (95% confidence interval, ؊576 to ؊24 dyne · s · m 2 /cm 5 ). Conclusions: The pharmacokinetics of bosentan in pediatric patients with pulmonary arterial hypertension and healthy adults are similar, and treatment with bosentan resulted in hemodynamic improvement. These results suggest that the applied dosing regimens may be appropriate to treat pediatric patients. (Clin Pharmacol Ther 2003;73:372-82.)</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10307602" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="13eb5cc9b882ad42224071db3f5336ea" rel="nofollow" data-download="{"attachment_id":47444073,"asset_id":10307602,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47444073/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="25260678" href="https://independent.academia.edu/ngocnguyen144">ngoc nguyen</a><script data-card-contents-for-user="25260678" type="text/json">{"id":25260678,"first_name":"ngoc","last_name":"nguyen","domain_name":"independent","page_name":"ngocnguyen144","display_name":"ngoc nguyen","profile_url":"https://independent.academia.edu/ngocnguyen144?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_10307602 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10307602"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10307602, container: ".js-paper-rank-work_10307602", }); });</script></li><li class="js-percentile-work_10307602 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 10307602; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_10307602"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_10307602 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="10307602"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 10307602; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=10307602]").text(description); $(".js-view-count-work_10307602").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_10307602").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="10307602"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12571" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Pharmacology">Clinical Pharmacology</a>, <script data-card-contents-for-ri="12571" type="text/json">{"id":12571,"name":"Clinical Pharmacology","url":"https://www.academia.edu/Documents/in/Clinical_Pharmacology?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" rel="nofollow" href="https://www.academia.edu/Documents/in/Child">Child</a><script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=10307602]'), work: {"id":10307602,"title":"Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension","created_at":"2015-01-24T00:27:28.715-08:00","url":"https://www.academia.edu/10307602/Pharmacokinetics_safety_and_efficacy_of_bosentan_in_pediatric_patients_with_pulmonary_arterial_hypertension?f_ri=31958","dom_id":"work_10307602","summary":"Background: Bosentan, a dual endothelin-receptor antagonist, is registered for the treatment of pulmonary arterial hypertension. Little is known about the effects of bosentan in children. This study was conducted to investigate the pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension. Methods: In this 2-center, open-label study, 19 pediatric patients with pulmonary arterial hypertension were enrolled and stratified for body weight and epoprostenol use. Patients weighing between 10 and 20 kg, between 20 and 40 kg, or greater than 40 kg received a single dose of 31.25, 62.5, or 125 mg, respectively, on day 1, followed by 4 weeks of treatment with the initial dose. The dose was then up-titrated to the target dose (31.25, 62.5, or 125 mg twice daily). Pharmacokinetic and hemodynamic parameters were obtained at baseline and after 12 weeks of treatment. Six-minute walk distance and cardiopulmonary exercise testing results were measured at baseline and at week 12 in children aged 8 years or older. Results: The variability in exposure among the 3 groups was less than 2-fold after single-and multiple-dose administration. The exposure to bosentan decreased over time in all groups. The covariates body weight, gender, age, and the use of epoprostenol had no significant effect on the pharmacokinetics of bosentan. Bosentan produced hemodynamic improvement and was well tolerated. The mean change from baseline in mean pulmonary artery pressure was ؊8.0 mm Hg (95% confidence interval, ؊12.2 to ؊3.7 mm Hg), and that in pulmonary vascular resistance index was ؊300 dyne · s · m 2 /cm 5 (95% confidence interval, ؊576 to ؊24 dyne · s · m 2 /cm 5 ). Conclusions: The pharmacokinetics of bosentan in pediatric patients with pulmonary arterial hypertension and healthy adults are similar, and treatment with bosentan resulted in hemodynamic improvement. These results suggest that the applied dosing regimens may be appropriate to treat pediatric patients. (Clin Pharmacol Ther 2003;73:372-82.)","downloadable_attachments":[{"id":47444073,"asset_id":10307602,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":25260678,"first_name":"ngoc","last_name":"nguyen","domain_name":"independent","page_name":"ngocnguyen144","display_name":"ngoc nguyen","profile_url":"https://independent.academia.edu/ngocnguyen144?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12571,"name":"Clinical Pharmacology","url":"https://www.academia.edu/Documents/in/Clinical_Pharmacology?f_ri=31958","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=31958","nofollow":true},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=31958"},{"id":276810,"name":"Shell Half-Life","url":"https://www.academia.edu/Documents/in/Shell_Half-Life?f_ri=31958"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance?f_ri=31958"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight?f_ri=31958"},{"id":1210718,"name":"Cardiopulmonary Exercise Testing","url":"https://www.academia.edu/Documents/in/Cardiopulmonary_Exercise_Testing?f_ri=31958"},{"id":1587858,"name":"Confidence Interval","url":"https://www.academia.edu/Documents/in/Confidence_Interval?f_ri=31958"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_34404308" data-work_id="34404308" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/34404308/Ventilation_perfusion_lung_scanning_in_the_evaluation_of_pulmonary_hypertension">Ventilation-perfusion lung scanning in the evaluation of pulmonary hypertension</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The objective of this study was to define the sensitivity, specificity and accuracy of ventilation-perfusion (V/Q) lung scanning in distinguishing chronic thromboembolic pulmonary hypertension (PHT) from other nonembolic causes of PHT.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_34404308" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The objective of this study was to define the sensitivity, specificity and accuracy of ventilation-perfusion (V/Q) lung scanning in distinguishing chronic thromboembolic pulmonary hypertension (PHT) from other nonembolic causes of PHT. The V/Q lung scans from 75 patients in whom a confirmed cause of PHT was established were retrospectively reviewed. Twenty-five patients (33%) had chronic thromboembolic PHT, whereas 35 patients (47%) and 15 patients (20%) suffered from primary PHT and secondary nonthromboembolic PHT, respectively. A high-probability V/Q scan interpretation had a sensitivity of 96% and a specificity of 94% for detecting patients with thromboembolic PHT. The combination of high- and intermediate-probability V/Q scan interpretations had a sensitivity of 100% for detecting patients with thromboembolic PH; however, the specificity decreased to 86%. Of the 35 patients with primary PHT, all but one patient had low-probability V/Q scan interpretations. In this series, a low-...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/34404308" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4c94ff157bb27b5deec14bf27a019345" rel="nofollow" data-download="{"attachment_id":54285658,"asset_id":34404308,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54285658/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35075800" href="https://independent.academia.edu/AbassAlavi">Abass Alavi</a><script data-card-contents-for-user="35075800" type="text/json">{"id":35075800,"first_name":"Abass","last_name":"Alavi","domain_name":"independent","page_name":"AbassAlavi","display_name":"Abass Alavi","profile_url":"https://independent.academia.edu/AbassAlavi?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_34404308 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="34404308"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 34404308, container: ".js-paper-rank-work_34404308", }); 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The V/Q lung scans from 75 patients in whom a confirmed cause of PHT was established were retrospectively reviewed. Twenty-five patients (33%) had chronic thromboembolic PHT, whereas 35 patients (47%) and 15 patients (20%) suffered from primary PHT and secondary nonthromboembolic PHT, respectively. A high-probability V/Q scan interpretation had a sensitivity of 96% and a specificity of 94% for detecting patients with thromboembolic PHT. The combination of high- and intermediate-probability V/Q scan interpretations had a sensitivity of 100% for detecting patients with thromboembolic PH; however, the specificity decreased to 86%. Of the 35 patients with primary PHT, all but one patient had low-probability V/Q scan interpretations. In this series, a low-...","downloadable_attachments":[{"id":54285658,"asset_id":34404308,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35075800,"first_name":"Abass","last_name":"Alavi","domain_name":"independent","page_name":"AbassAlavi","display_name":"Abass Alavi","profile_url":"https://independent.academia.edu/AbassAlavi?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":10035,"name":"Nuclear medicine","url":"https://www.academia.edu/Documents/in/Nuclear_medicine?f_ri=31958","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":71308,"name":"Pulmonary fibrosis","url":"https://www.academia.edu/Documents/in/Pulmonary_fibrosis?f_ri=31958","nofollow":true},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=31958"},{"id":102587,"name":"Pulmonary Embolism","url":"https://www.academia.edu/Documents/in/Pulmonary_Embolism?f_ri=31958"},{"id":176423,"name":"Thromboembolism","url":"https://www.academia.edu/Documents/in/Thromboembolism?f_ri=31958"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung?f_ri=31958"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=31958"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=31958"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=31958"},{"id":2226523,"name":"Pulmonary circulation","url":"https://www.academia.edu/Documents/in/Pulmonary_circulation?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10145857" data-work_id="10145857" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10145857/Anatomic_correction_of_transposition_of_the_great_arteries">Anatomic correction of transposition of the great arteries</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Inversion of the atrial flow in transposition of the great arteries is achieved in the following way: the remaining atrial septum is detached from behind, leaving it as a flap between both AVvalves. The incision is continued into the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10145857" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Inversion of the atrial flow in transposition of the great arteries is achieved in the following way: the remaining atrial septum is detached from behind, leaving it as a flap between both AVvalves. The incision is continued into the coronary sinus and the Vena magna cordis to the base of the left atrial appendage along the mitral ring. The resulting flap from the split coronary sinus is sutured to the left atrial wail in front of the left side pulmonary veins, thus forming a septum dorsal to the caval veins, diverting the left pulmonary venous blood to the right side. The atrial septal</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10145857" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5a0fd4c307364e8f67edfc252e62e64c" rel="nofollow" data-download="{"attachment_id":47510212,"asset_id":10145857,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47510212/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="24769887" href="https://independent.academia.edu/camiloneto">camilo neto</a><script data-card-contents-for-user="24769887" type="text/json">{"id":24769887,"first_name":"camilo","last_name":"neto","domain_name":"independent","page_name":"camiloneto","display_name":"camilo neto","profile_url":"https://independent.academia.edu/camiloneto?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_10145857 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10145857"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10145857, container: ".js-paper-rank-work_10145857", }); 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class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20285588" data-work_id="20285588" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20285588/Comparison_of_Endothelial_Biomarkers_According_to_Reversibility_of_Pulmonary_Hypertension_Secondary_to_Congenital_Heart_Disease">Comparison of Endothelial Biomarkers According to Reversibility of Pulmonary Hypertension Secondary to Congenital Heart Disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The reversibility of pulmonary arterial hypertension (PAH) in children with congenital heart disease (CHD) is strongly associated with the degree of intimal proliferation, vessel narrowing, and number of circulating endothelial cells... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20285588" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The reversibility of pulmonary arterial hypertension (PAH) in children with congenital heart disease (CHD) is strongly associated with the degree of intimal proliferation, vessel narrowing, and number of circulating endothelial cells (CECs). Circulating endothelial cells may arise from either endothelial damage or accelerated turnover during vessel remodeling, but nothing is known about endothelial microparticles (EMPs) and other biomarkers reflecting endothelial alterations. This study aimed to document endothelial markers further according to the irreversibility of PAH secondary to CHD. The study investigated soluble markers of endothelial damage or activation (thrombomodulin, soluble endothelial protein C receptor, and soluble E-selectin), inflammation (interleukin-6), and angiogenic cytokine levels [vascular endothelial growth factor (VEGF) and placental growth factor (PlGF)] in 26 patients with CHD, 16 with reversible PAH (median age, 2 years) and 10 with irreversible PAH (median age, 9 years). Endothelial activation/apoptosis was evaluated by measuring EMP levels. Plasma procoagulant activity also was measured. The results show that the levels of soluble markers indicating endothelial activation were not predictors of PAH irreversibility. Lower levels of PlGF were observed in reversible compared with irreversible PAH but were not associated with the CEC level, the mean pulmonary artery pressure (mPAP), or age. No significant difference in procoagulant activity or EMP level was found between irreversible and reversible PAH. Among a large panel of biomarkers reflecting endothelial activation, regeneration, and injury, the high CEC levels previously described proved to be the only marker allowing discrimination between reversible and irreversible PAH secondary to CHD.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20285588" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3c23177cb402e94f3da0527e83acdaa4" rel="nofollow" data-download="{"attachment_id":41970845,"asset_id":20285588,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41970845/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41520379" href="https://independent.academia.edu/PascaleGaussem">Pascale Gaussem</a><script data-card-contents-for-user="41520379" type="text/json">{"id":41520379,"first_name":"Pascale","last_name":"Gaussem","domain_name":"independent","page_name":"PascaleGaussem","display_name":"Pascale Gaussem","profile_url":"https://independent.academia.edu/PascaleGaussem?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_20285588 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20285588"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20285588, container: ".js-paper-rank-work_20285588", }); });</script></li><li class="js-percentile-work_20285588 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20285588; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_20285588"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_20285588 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="20285588"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20285588; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20285588]").text(description); $(".js-view-count-work_20285588").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20285588").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20285588"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3243" rel="nofollow" href="https://www.academia.edu/Documents/in/Nonparametric_Statistics">Nonparametric Statistics</a>, <script data-card-contents-for-ri="3243" type="text/json">{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37788" rel="nofollow" href="https://www.academia.edu/Documents/in/Pediatric_Cardiology">Pediatric Cardiology</a>, <script data-card-contents-for-ri="37788" type="text/json">{"id":37788,"name":"Pediatric Cardiology","url":"https://www.academia.edu/Documents/in/Pediatric_Cardiology?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="57980" rel="nofollow" href="https://www.academia.edu/Documents/in/Congenital_Heart_Defects">Congenital Heart Defects</a><script data-card-contents-for-ri="57980" type="text/json">{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20285588]'), work: {"id":20285588,"title":"Comparison of Endothelial Biomarkers According to Reversibility of Pulmonary Hypertension Secondary to Congenital Heart Disease","created_at":"2016-01-15T03:02:04.272-08:00","url":"https://www.academia.edu/20285588/Comparison_of_Endothelial_Biomarkers_According_to_Reversibility_of_Pulmonary_Hypertension_Secondary_to_Congenital_Heart_Disease?f_ri=31958","dom_id":"work_20285588","summary":"The reversibility of pulmonary arterial hypertension (PAH) in children with congenital heart disease (CHD) is strongly associated with the degree of intimal proliferation, vessel narrowing, and number of circulating endothelial cells (CECs). Circulating endothelial cells may arise from either endothelial damage or accelerated turnover during vessel remodeling, but nothing is known about endothelial microparticles (EMPs) and other biomarkers reflecting endothelial alterations. This study aimed to document endothelial markers further according to the irreversibility of PAH secondary to CHD. The study investigated soluble markers of endothelial damage or activation (thrombomodulin, soluble endothelial protein C receptor, and soluble E-selectin), inflammation (interleukin-6), and angiogenic cytokine levels [vascular endothelial growth factor (VEGF) and placental growth factor (PlGF)] in 26 patients with CHD, 16 with reversible PAH (median age, 2 years) and 10 with irreversible PAH (median age, 9 years). Endothelial activation/apoptosis was evaluated by measuring EMP levels. Plasma procoagulant activity also was measured. The results show that the levels of soluble markers indicating endothelial activation were not predictors of PAH irreversibility. Lower levels of PlGF were observed in reversible compared with irreversible PAH but were not associated with the CEC level, the mean pulmonary artery pressure (mPAP), or age. No significant difference in procoagulant activity or EMP level was found between irreversible and reversible PAH. Among a large panel of biomarkers reflecting endothelial activation, regeneration, and injury, the high CEC levels previously described proved to be the only marker allowing discrimination between reversible and irreversible PAH secondary to CHD.","downloadable_attachments":[{"id":41970845,"asset_id":20285588,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":41520379,"first_name":"Pascale","last_name":"Gaussem","domain_name":"independent","page_name":"PascaleGaussem","display_name":"Pascale Gaussem","profile_url":"https://independent.academia.edu/PascaleGaussem?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":37788,"name":"Pediatric Cardiology","url":"https://www.academia.edu/Documents/in/Pediatric_Cardiology?f_ri=31958","nofollow":true},{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects?f_ri=31958","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=31958"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=31958"},{"id":138877,"name":"Vascular endothelium","url":"https://www.academia.edu/Documents/in/Vascular_endothelium?f_ri=31958"},{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric?f_ri=31958"},{"id":401214,"name":"Endothelial cell","url":"https://www.academia.edu/Documents/in/Endothelial_cell?f_ri=31958"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=31958"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=31958"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=31958"},{"id":735030,"name":"Congenital Heart Disease","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Disease?f_ri=31958"},{"id":951344,"name":"Growth Factor","url":"https://www.academia.edu/Documents/in/Growth_Factor?f_ri=31958"},{"id":1796877,"name":"Vascular Endothelial Growth Factor","url":"https://www.academia.edu/Documents/in/Vascular_Endothelial_Growth_Factor?f_ri=31958"},{"id":1969879,"name":"Vascular Resistance","url":"https://www.academia.edu/Documents/in/Vascular_Resistance?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_49065214" data-work_id="49065214" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/49065214/Illness_and_Object_Relations_Narratives_From_Women_With_Pulmonary_Hypertension">Illness and Object Relations: Narratives From Women With Pulmonary Hypertension</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objectives The current research study aims at investigating the illness experience of people affected by Pulmonary Hypertension (PH), as a particularly challenging rare disease that is paradigmatic for the understanding of regulatory... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_49065214" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objectives The current research study aims at investigating the illness experience of people affected by Pulmonary Hypertension (PH), as a particularly challenging rare disease that is paradigmatic for the understanding of regulatory processes. Methods The study used Giorgi's method to analyze the illness narratives of 11 adult Italian women affected by PH according to a qualitative phenomenological approach. An object relations perspective looking at chronic illness as an internal object was adopted for result interpretation. Results Four general themes were identified that characterize illness narratives of people with PH and illustrate the progressive stages of the disease. They respectively deal with the body/mind disruption at symptom onset, the protagonization of illness in the search for a diagnosis, the complicated grief at the time of diagnosis, and the anaclitic strategies to face the future. Conclusion Findings make a significant contribution to the exploration of the subjective experience of people with PH in managing illness-related challenges from symptom onset to after diagnosis.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/49065214" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fc5700e6af078320409fb8ec01ded244" rel="nofollow" data-download="{"attachment_id":67456730,"asset_id":49065214,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67456730/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="77158625" href="https://iums.academia.edu/IranianJournalofPsychiatryClinicalPsychologyIJPCP">Iranian Journal of Psychiatry & Clinical Psychology (IJPCP)</a><script data-card-contents-for-user="77158625" type="text/json">{"id":77158625,"first_name":"Iranian Journal of Psychiatry \u0026 Clinical Psychology","last_name":"(IJPCP)","domain_name":"iums","page_name":"IranianJournalofPsychiatryClinicalPsychologyIJPCP","display_name":"Iranian Journal of Psychiatry \u0026 Clinical Psychology (IJPCP)","profile_url":"https://iums.academia.edu/IranianJournalofPsychiatryClinicalPsychologyIJPCP?f_ri=31958","photo":"https://0.academia-photos.com/77158625/19119988/19068972/s65_iranian_journal_of_psychiatry_clinical_psychology._ijpcp_.jpg"}</script></span></span></li><li class="js-paper-rank-work_49065214 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="49065214"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 49065214, container: ".js-paper-rank-work_49065214", }); });</script></li><li class="js-percentile-work_49065214 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 49065214; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_49065214"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_49065214 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="49065214"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 49065214; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=49065214]").text(description); $(".js-view-count-work_49065214").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_49065214").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="49065214"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="244" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychoanalysis">Psychoanalysis</a>, <script data-card-contents-for-ri="244" type="text/json">{"id":244,"name":"Psychoanalysis","url":"https://www.academia.edu/Documents/in/Psychoanalysis?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12135" rel="nofollow" href="https://www.academia.edu/Documents/in/Qualitative_Research">Qualitative Research</a>, <script data-card-contents-for-ri="12135" type="text/json">{"id":12135,"name":"Qualitative Research","url":"https://www.academia.edu/Documents/in/Qualitative_Research?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="241911" rel="nofollow" href="https://www.academia.edu/Documents/in/Self-Perception">Self-Perception</a><script data-card-contents-for-ri="241911" type="text/json">{"id":241911,"name":"Self-Perception","url":"https://www.academia.edu/Documents/in/Self-Perception?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=49065214]'), work: {"id":49065214,"title":"Illness and Object Relations: Narratives From Women With Pulmonary Hypertension","created_at":"2021-05-29T04:42:00.904-07:00","url":"https://www.academia.edu/49065214/Illness_and_Object_Relations_Narratives_From_Women_With_Pulmonary_Hypertension?f_ri=31958","dom_id":"work_49065214","summary":"Objectives The current research study aims at investigating the illness experience of people affected by Pulmonary Hypertension (PH), as a particularly challenging rare disease that is paradigmatic for the understanding of regulatory processes. Methods The study used Giorgi's method to analyze the illness narratives of 11 adult Italian women affected by PH according to a qualitative phenomenological approach. An object relations perspective looking at chronic illness as an internal object was adopted for result interpretation. Results Four general themes were identified that characterize illness narratives of people with PH and illustrate the progressive stages of the disease. They respectively deal with the body/mind disruption at symptom onset, the protagonization of illness in the search for a diagnosis, the complicated grief at the time of diagnosis, and the anaclitic strategies to face the future. Conclusion Findings make a significant contribution to the exploration of the subjective experience of people with PH in managing illness-related challenges from symptom onset to after diagnosis.","downloadable_attachments":[{"id":67456730,"asset_id":49065214,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":77158625,"first_name":"Iranian Journal of Psychiatry \u0026 Clinical Psychology","last_name":"(IJPCP)","domain_name":"iums","page_name":"IranianJournalofPsychiatryClinicalPsychologyIJPCP","display_name":"Iranian Journal of Psychiatry \u0026 Clinical Psychology (IJPCP)","profile_url":"https://iums.academia.edu/IranianJournalofPsychiatryClinicalPsychologyIJPCP?f_ri=31958","photo":"https://0.academia-photos.com/77158625/19119988/19068972/s65_iranian_journal_of_psychiatry_clinical_psychology._ijpcp_.jpg"}],"research_interests":[{"id":244,"name":"Psychoanalysis","url":"https://www.academia.edu/Documents/in/Psychoanalysis?f_ri=31958","nofollow":true},{"id":12135,"name":"Qualitative Research","url":"https://www.academia.edu/Documents/in/Qualitative_Research?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":241911,"name":"Self-Perception","url":"https://www.academia.edu/Documents/in/Self-Perception?f_ri=31958","nofollow":true},{"id":429764,"name":"Personal Narrative","url":"https://www.academia.edu/Documents/in/Personal_Narrative?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_33110200" data-work_id="33110200" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/33110200/Pulmonary_hypertension_in_patients_with_end_stage_renal_disease">Pulmonary hypertension in patients with end-stage renal disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: The aims of this study were to evaluate the incidence of unexplained pulmonary hypertension (PH) among patients with end-stage renal disease (ESRD) and to suggest possible etiologic factors. Methods: The incidence of PH was... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_33110200" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: The aims of this study were to evaluate the incidence of unexplained pulmonary hypertension (PH) among patients with end-stage renal disease (ESRD) and to suggest possible etiologic factors. Methods: The incidence of PH was prospectively estimated by Doppler echocardiography in 58 patients with ESRD receiving long-term hemodialysis via arteriovenous access, and in control groups of 5 patients receiving peritoneal dialysis (PD) and 12 predialysis patients without a known other cause to suggest the presence of PH. Clinical variables were compared between patients with and without PH receiving hemodialysis. Changes in pulmonary artery pressure (PAP) values before and after onset of hemodialysis via arteriovenous access, arteriovenous access compression, and successful kidney transplantation were recorded. Results: PH > 35 mm Hg was found in 39.7% of patients receiving hemodialysis (mean ؎ SD, 44 ؎ 7 mm Hg; range, 37 to 65 mm Hg), in none of the patients receiving PD, and in 1 of 12 predialysis patients. Patients with PH receiving hemodialysis had a significantly higher cardiac output (6.9 L/min vs 5.5 L/min, p ‫؍‬ 0.017). PH developed in four of six patients with normal PAP after onset of hemodialysis therapy via arteriovenous access. One-minute arteriovenous access compression in four patients decreased the mean systolic PAP from 52 ؎ 7 to 41 ؎ 4 mm Hg (p ‫؍‬ 0.024). PH normalized in four of five patients receiving hemodialysis following kidney transplantation. Kaplan-Meier survival analysis according to PAP values revealed significant survival differences (p < 0.024).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/33110200" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ec2149a96983feaa8b57c795a7b63730" rel="nofollow" data-download="{"attachment_id":53206149,"asset_id":33110200,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/53206149/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35484580" href="https://independent.academia.edu/FaridNakhoul">Farid Nakhoul</a><script data-card-contents-for-user="35484580" type="text/json">{"id":35484580,"first_name":"Farid","last_name":"Nakhoul","domain_name":"independent","page_name":"FaridNakhoul","display_name":"Farid Nakhoul","profile_url":"https://independent.academia.edu/FaridNakhoul?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_33110200 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="33110200"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 33110200, container: ".js-paper-rank-work_33110200", }); });</script></li><li class="js-percentile-work_33110200 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 33110200; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_33110200"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_33110200 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="33110200"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33110200; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=33110200]").text(description); $(".js-view-count-work_33110200").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_33110200").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="33110200"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="647" rel="nofollow" href="https://www.academia.edu/Documents/in/Surgery">Surgery</a>, <script data-card-contents-for-ri="647" type="text/json">{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9003" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_transplantation">Kidney transplantation</a>, <script data-card-contents-for-ri="9003" type="text/json">{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a><script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=33110200]'), work: {"id":33110200,"title":"Pulmonary hypertension in patients with end-stage renal disease","created_at":"2017-05-20T02:56:47.661-07:00","url":"https://www.academia.edu/33110200/Pulmonary_hypertension_in_patients_with_end_stage_renal_disease?f_ri=31958","dom_id":"work_33110200","summary":"Background: The aims of this study were to evaluate the incidence of unexplained pulmonary hypertension (PH) among patients with end-stage renal disease (ESRD) and to suggest possible etiologic factors. Methods: The incidence of PH was prospectively estimated by Doppler echocardiography in 58 patients with ESRD receiving long-term hemodialysis via arteriovenous access, and in control groups of 5 patients receiving peritoneal dialysis (PD) and 12 predialysis patients without a known other cause to suggest the presence of PH. Clinical variables were compared between patients with and without PH receiving hemodialysis. Changes in pulmonary artery pressure (PAP) values before and after onset of hemodialysis via arteriovenous access, arteriovenous access compression, and successful kidney transplantation were recorded. Results: PH \u003e 35 mm Hg was found in 39.7% of patients receiving hemodialysis (mean ؎ SD, 44 ؎ 7 mm Hg; range, 37 to 65 mm Hg), in none of the patients receiving PD, and in 1 of 12 predialysis patients. Patients with PH receiving hemodialysis had a significantly higher cardiac output (6.9 L/min vs 5.5 L/min, p ‫؍‬ 0.017). PH developed in four of six patients with normal PAP after onset of hemodialysis therapy via arteriovenous access. One-minute arteriovenous access compression in four patients decreased the mean systolic PAP from 52 ؎ 7 to 41 ؎ 4 mm Hg (p ‫؍‬ 0.024). PH normalized in four of five patients receiving hemodialysis following kidney transplantation. Kaplan-Meier survival analysis according to PAP values revealed significant survival differences (p \u003c 0.024).","downloadable_attachments":[{"id":53206149,"asset_id":33110200,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35484580,"first_name":"Farid","last_name":"Nakhoul","domain_name":"independent","page_name":"FaridNakhoul","display_name":"Farid Nakhoul","profile_url":"https://independent.academia.edu/FaridNakhoul?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=31958","nofollow":true},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=31958","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=31958"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=31958"},{"id":426578,"name":"Cardiac Output Monitoring","url":"https://www.academia.edu/Documents/in/Cardiac_Output_Monitoring?f_ri=31958"},{"id":532928,"name":"Chest","url":"https://www.academia.edu/Documents/in/Chest?f_ri=31958"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure?f_ri=31958"},{"id":1611680,"name":"Renal Dialysis","url":"https://www.academia.edu/Documents/in/Renal_Dialysis?f_ri=31958"},{"id":2369445,"name":"Pulmonary Artery","url":"https://www.academia.edu/Documents/in/Pulmonary_Artery?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24947215" data-work_id="24947215" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24947215/Pulmonary_thromboendarterectomy_surgery">Pulmonary thromboendarterectomy surgery</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Considerable progress has been made over the past decade in understanding the etiology, prevalence, natural history, and therapeutic approach to chronic thromboembolic pulmonary hypertension. Pulmonary endarterectomy is now widely... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24947215" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Considerable progress has been made over the past decade in understanding the etiology, prevalence, natural history, and therapeutic approach to chronic thromboembolic pulmonary hypertension. Pulmonary endarterectomy is now widely recognized as the definitive treatment for chronic pulmonary hypertension resulting from thromboembolic disease. This article focuses on the surgical treatment of chronic thromboembolic pulmonary hypertension.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24947215" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3f7a60831060c3c986935954642892a9" rel="nofollow" data-download="{"attachment_id":45277995,"asset_id":24947215,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45277995/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33257578" href="https://ucsd.academia.edu/StuartJamieson">Stuart Jamieson</a><script data-card-contents-for-user="33257578" type="text/json">{"id":33257578,"first_name":"Stuart","last_name":"Jamieson","domain_name":"ucsd","page_name":"StuartJamieson","display_name":"Stuart Jamieson","profile_url":"https://ucsd.academia.edu/StuartJamieson?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24947215 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24947215"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24947215, container: ".js-paper-rank-work_24947215", }); });</script></li><li class="js-percentile-work_24947215 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24947215; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24947215"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24947215 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24947215"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24947215; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24947215]").text(description); $(".js-view-count-work_24947215").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24947215").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24947215"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="97269" rel="nofollow" href="https://www.academia.edu/Documents/in/Chronic_Disease">Chronic Disease</a>, <script data-card-contents-for-ri="97269" type="text/json">{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="102587" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Embolism">Pulmonary Embolism</a>, <script data-card-contents-for-ri="102587" type="text/json">{"id":102587,"name":"Pulmonary Embolism","url":"https://www.academia.edu/Documents/in/Pulmonary_Embolism?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="480301" rel="nofollow" href="https://www.academia.edu/Documents/in/Carotid_Endarterectomy">Carotid Endarterectomy</a><script data-card-contents-for-ri="480301" type="text/json">{"id":480301,"name":"Carotid Endarterectomy","url":"https://www.academia.edu/Documents/in/Carotid_Endarterectomy?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24947215]'), work: {"id":24947215,"title":"Pulmonary thromboendarterectomy surgery","created_at":"2016-05-02T07:17:48.030-07:00","url":"https://www.academia.edu/24947215/Pulmonary_thromboendarterectomy_surgery?f_ri=31958","dom_id":"work_24947215","summary":"Considerable progress has been made over the past decade in understanding the etiology, prevalence, natural history, and therapeutic approach to chronic thromboembolic pulmonary hypertension. Pulmonary endarterectomy is now widely recognized as the definitive treatment for chronic pulmonary hypertension resulting from thromboembolic disease. This article focuses on the surgical treatment of chronic thromboembolic pulmonary hypertension.","downloadable_attachments":[{"id":45277995,"asset_id":24947215,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33257578,"first_name":"Stuart","last_name":"Jamieson","domain_name":"ucsd","page_name":"StuartJamieson","display_name":"Stuart Jamieson","profile_url":"https://ucsd.academia.edu/StuartJamieson?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=31958","nofollow":true},{"id":102587,"name":"Pulmonary Embolism","url":"https://www.academia.edu/Documents/in/Pulmonary_Embolism?f_ri=31958","nofollow":true},{"id":480301,"name":"Carotid Endarterectomy","url":"https://www.academia.edu/Documents/in/Carotid_Endarterectomy?f_ri=31958","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24592656" data-work_id="24592656" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24592656/Hemoglobin_sickle_cell_disease_in_Brazil">Hemoglobin sickle cell disease in Brazil</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24592656" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f6196f24d067e73e6566613d1fb0defc" rel="nofollow" data-download="{"attachment_id":44921701,"asset_id":24592656,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44921701/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="47406300" href="https://unifesp.academia.edu/mariastellafigueiredo">maria stella figueiredo</a><script data-card-contents-for-user="47406300" type="text/json">{"id":47406300,"first_name":"maria stella","last_name":"figueiredo","domain_name":"unifesp","page_name":"mariastellafigueiredo","display_name":"maria stella figueiredo","profile_url":"https://unifesp.academia.edu/mariastellafigueiredo?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24592656 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24592656"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24592656, container: ".js-paper-rank-work_24592656", }); });</script></li><li class="js-percentile-work_24592656 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24592656; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24592656"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24592656 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24592656"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24592656; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24592656]").text(description); $(".js-view-count-work_24592656").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24592656").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24592656"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="5569" rel="nofollow" href="https://www.academia.edu/Documents/in/Sickle_Cell_Anemia">Sickle Cell Anemia</a>, <script data-card-contents-for-ri="5569" type="text/json">{"id":5569,"name":"Sickle Cell Anemia","url":"https://www.academia.edu/Documents/in/Sickle_Cell_Anemia?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8999" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_diseases">Kidney diseases</a>, <script data-card-contents-for-ri="8999" type="text/json">{"id":8999,"name":"Kidney diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a><script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24592656]'), work: {"id":24592656,"title":"Hemoglobin sickle cell disease in Brazil","created_at":"2016-04-20T07:18:07.404-07:00","url":"https://www.academia.edu/24592656/Hemoglobin_sickle_cell_disease_in_Brazil?f_ri=31958","dom_id":"work_24592656","summary":null,"downloadable_attachments":[{"id":44921701,"asset_id":24592656,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":47406300,"first_name":"maria stella","last_name":"figueiredo","domain_name":"unifesp","page_name":"mariastellafigueiredo","display_name":"maria stella figueiredo","profile_url":"https://unifesp.academia.edu/mariastellafigueiredo?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":5569,"name":"Sickle Cell Anemia","url":"https://www.academia.edu/Documents/in/Sickle_Cell_Anemia?f_ri=31958","nofollow":true},{"id":8999,"name":"Kidney diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14319679" data-work_id="14319679" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14319679/Reactive_oxygen_species_production_in_the_early_and_later_stage_of_chronic_ventilatory_hypoxia">Reactive oxygen species production in the early and later stage of chronic ventilatory hypoxia</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Pulmonary hypertension resulting from chronic hypoxia is at least partly caused by the increased production of reactive oxygen species (ROS). The goal of the presented study was to investigate the dynamics and the site of production of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14319679" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Pulmonary hypertension resulting from chronic hypoxia is at least partly caused by the increased production of reactive oxygen species (ROS). The goal of the presented study was to investigate the dynamics and the site of production of ROS during chronic hypoxia. In our study Wistar rats were kept for 1, 4 and 21 days in an isobaric hypoxic chamber (F(iO2)=0.1), while controls stayed in normoxia. We compared NO production in expired air, plasma and perfusate drained from isolated rat lungs and measured superoxide concentration in the perfusate. We also detected the presence of superoxide products (hydrogen peroxide and peroxynitrite) and the level of ROS-induced damage expressed as the concentration of lipid peroxydation end products. We found that the production and release of ROS and NO during early phase of chronic hypoxia has specific timing and differs in various compartments, suggesting the crucial role of ROS interaction for development of hypoxic pulmonary hypertension.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14319679" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4529e302808834b5c218c71bc92cfb12" rel="nofollow" data-download="{"attachment_id":44323677,"asset_id":14319679,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44323677/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33273328" href="https://independent.academia.edu/HMaxov%C3%A1">H. Maxová</a><script data-card-contents-for-user="33273328" type="text/json">{"id":33273328,"first_name":"H.","last_name":"Maxová","domain_name":"independent","page_name":"HMaxová","display_name":"H. Maxová","profile_url":"https://independent.academia.edu/HMaxov%C3%A1?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14319679 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14319679"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14319679, container: ".js-paper-rank-work_14319679", }); });</script></li><li class="js-percentile-work_14319679 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14319679; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_14319679"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14319679 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14319679"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14319679; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14319679]").text(description); $(".js-view-count-work_14319679").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14319679").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14319679"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="67133" rel="nofollow" href="https://www.academia.edu/Documents/in/Anoxia">Anoxia</a>, <script data-card-contents-for-ri="67133" type="text/json">{"id":67133,"name":"Anoxia","url":"https://www.academia.edu/Documents/in/Anoxia?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="82978" rel="nofollow" href="https://www.academia.edu/Documents/in/Reactive_Oxygen_Species">Reactive Oxygen Species</a>, <script data-card-contents-for-ri="82978" type="text/json">{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="93922" rel="nofollow" href="https://www.academia.edu/Documents/in/Nitric_oxide">Nitric oxide</a><script data-card-contents-for-ri="93922" type="text/json">{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14319679]'), work: {"id":14319679,"title":"Reactive oxygen species production in the early and later stage of chronic ventilatory hypoxia","created_at":"2015-07-22T23:36:06.116-07:00","url":"https://www.academia.edu/14319679/Reactive_oxygen_species_production_in_the_early_and_later_stage_of_chronic_ventilatory_hypoxia?f_ri=31958","dom_id":"work_14319679","summary":"Pulmonary hypertension resulting from chronic hypoxia is at least partly caused by the increased production of reactive oxygen species (ROS). The goal of the presented study was to investigate the dynamics and the site of production of ROS during chronic hypoxia. In our study Wistar rats were kept for 1, 4 and 21 days in an isobaric hypoxic chamber (F(iO2)=0.1), while controls stayed in normoxia. We compared NO production in expired air, plasma and perfusate drained from isolated rat lungs and measured superoxide concentration in the perfusate. We also detected the presence of superoxide products (hydrogen peroxide and peroxynitrite) and the level of ROS-induced damage expressed as the concentration of lipid peroxydation end products. We found that the production and release of ROS and NO during early phase of chronic hypoxia has specific timing and differs in various compartments, suggesting the crucial role of ROS interaction for development of hypoxic pulmonary hypertension.","downloadable_attachments":[{"id":44323677,"asset_id":14319679,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33273328,"first_name":"H.","last_name":"Maxová","domain_name":"independent","page_name":"HMaxová","display_name":"H. Maxová","profile_url":"https://independent.academia.edu/HMaxov%C3%A1?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":67133,"name":"Anoxia","url":"https://www.academia.edu/Documents/in/Anoxia?f_ri=31958","nofollow":true},{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species?f_ri=31958","nofollow":true},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=31958","nofollow":true},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=31958"},{"id":274826,"name":"Hydrogen Peroxide","url":"https://www.academia.edu/Documents/in/Hydrogen_Peroxide?f_ri=31958"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=31958"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats?f_ri=31958"},{"id":2369445,"name":"Pulmonary Artery","url":"https://www.academia.edu/Documents/in/Pulmonary_Artery?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19169342" data-work_id="19169342" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19169342/Pregnancy_and_Cardiovascular_Disease">Pregnancy and Cardiovascular Disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The cardiovascular system undergoes significant changes during pregnancy to adapt to and accommodate the increased metabolic demands of the fetus and the mother. 1-5 These adaptations produce an important hemodynamic burden on patients... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_19169342" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The cardiovascular system undergoes significant changes during pregnancy to adapt to and accommodate the increased metabolic demands of the fetus and the mother. 1-5 These adaptations produce an important hemodynamic burden on patients with underlying heart disease, and confer an increase in morbidity and mortality. Furthermore, pregnancy may cause specific cardiovascular disorders, which can impose a risk to the pregnant woman and to her fetus. It is estimated that in the western world 0.2-4% of all pregnancies are complicated by cardiovascular diseases (CVD). 4 This risk is in the ascending order as the age of first pregnancy is increasing and as the number of cardiovascular risk factors is rising (e.g. smoking, hypercholesterolemia, diabetes, hypertension, obesity). During pregnancy, the most frequent cardiovascular events relate to hypertension (6-8%). On the other hand, in the western world, the most frequent CVD present during pregnancy is congenital heart disease-CHD (circa 75%), 4,6,7 while rheumatic heart disease predominates in the other countries (circa 70%) and CHD is seen in ~15%. In pregnant women with heart disease, maternal death is estimated around 1% but it varies depending on the underlying CVD; neonatal complications occur in 20-28% and neonatal mortality ranges between 1% and 4%. In general, CVDs are the most common cause of maternal death during pregnancy in the Western industrialized world. 4 Thus, women of child-bearing age with CVD or cardiovascular risk factors should be counseled and managed early by an interdisciplinary team of gynecologists, cardiologists, and, when necessary, cardiothoracic surgeons. To meet the metabolic demands of mother and fetus, cardiac output increases 1 L/min at 8 weeks' gestation, representing >50% of the total change seen, which culminates in an increase of cardiac output of 30-50% during normal pregnancy, maintained until term. 9,10 Cardiac output increases primarily because of stroke volume rather than heart rate, at least in early pregnancy, while later the heart rate also increases. By 8 weeks' gestation, systemic vascular resistance has fallen to 70% of its preconceptional value. The majority of the pregnancy-induced changes in these parameters occur during the embryonic period. Plasma volume has increased by ~40% at 24 weeks of gestation. Blood pressure falls mainly due to vasodilation, primarily conferred by nitric oxide and relaxin, affecting both systolic and diastolic components. In the third trimester, diastolic pressure gradually rises and may normalize to baseline values at term. Another important aspect of the cardiovascular status in pregnancy relates to hemostatic changes, which lead to hypercoagulability via an increase in concentration of coagulation factors, fibrinogen, and</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19169342" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6c69c88fc480e95d9b2e4dfd683677ad" rel="nofollow" data-download="{"attachment_id":40469252,"asset_id":19169342,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40469252/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="24274079" href="https://uoa.academia.edu/AM">Antonis Manolis</a><script data-card-contents-for-user="24274079" type="text/json">{"id":24274079,"first_name":"Antonis","last_name":"Manolis","domain_name":"uoa","page_name":"AM","display_name":"Antonis Manolis","profile_url":"https://uoa.academia.edu/AM?f_ri=31958","photo":"https://0.academia-photos.com/24274079/51142592/39201964/s65_antonis.manolis.jpg"}</script></span></span></li><li class="js-paper-rank-work_19169342 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19169342"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 19169342, container: ".js-paper-rank-work_19169342", }); 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$(".js-view-count[data-work-id=19169342]").text(description); $(".js-view-count-work_19169342").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_19169342").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="19169342"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9478" rel="nofollow" href="https://www.academia.edu/Documents/in/Diet">Diet</a>, <script data-card-contents-for-ri="9478" type="text/json">{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="38676" rel="nofollow" href="https://www.academia.edu/Documents/in/Anxiety">Anxiety</a>, <script data-card-contents-for-ri="38676" type="text/json">{"id":38676,"name":"Anxiety","url":"https://www.academia.edu/Documents/in/Anxiety?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62550" rel="nofollow" href="https://www.academia.edu/Documents/in/Pregnancy">Pregnancy</a><script data-card-contents-for-ri="62550" type="text/json">{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=19169342]'), work: {"id":19169342,"title":"Pregnancy and Cardiovascular Disease","created_at":"2015-11-29T02:44:39.734-08:00","url":"https://www.academia.edu/19169342/Pregnancy_and_Cardiovascular_Disease?f_ri=31958","dom_id":"work_19169342","summary":"The cardiovascular system undergoes significant changes during pregnancy to adapt to and accommodate the increased metabolic demands of the fetus and the mother. 1-5 These adaptations produce an important hemodynamic burden on patients with underlying heart disease, and confer an increase in morbidity and mortality. Furthermore, pregnancy may cause specific cardiovascular disorders, which can impose a risk to the pregnant woman and to her fetus. It is estimated that in the western world 0.2-4% of all pregnancies are complicated by cardiovascular diseases (CVD). 4 This risk is in the ascending order as the age of first pregnancy is increasing and as the number of cardiovascular risk factors is rising (e.g. smoking, hypercholesterolemia, diabetes, hypertension, obesity). During pregnancy, the most frequent cardiovascular events relate to hypertension (6-8%). On the other hand, in the western world, the most frequent CVD present during pregnancy is congenital heart disease-CHD (circa 75%), 4,6,7 while rheumatic heart disease predominates in the other countries (circa 70%) and CHD is seen in ~15%. In pregnant women with heart disease, maternal death is estimated around 1% but it varies depending on the underlying CVD; neonatal complications occur in 20-28% and neonatal mortality ranges between 1% and 4%. In general, CVDs are the most common cause of maternal death during pregnancy in the Western industrialized world. 4 Thus, women of child-bearing age with CVD or cardiovascular risk factors should be counseled and managed early by an interdisciplinary team of gynecologists, cardiologists, and, when necessary, cardiothoracic surgeons. To meet the metabolic demands of mother and fetus, cardiac output increases 1 L/min at 8 weeks' gestation, representing \u003e50% of the total change seen, which culminates in an increase of cardiac output of 30-50% during normal pregnancy, maintained until term. 9,10 Cardiac output increases primarily because of stroke volume rather than heart rate, at least in early pregnancy, while later the heart rate also increases. By 8 weeks' gestation, systemic vascular resistance has fallen to 70% of its preconceptional value. The majority of the pregnancy-induced changes in these parameters occur during the embryonic period. Plasma volume has increased by ~40% at 24 weeks of gestation. Blood pressure falls mainly due to vasodilation, primarily conferred by nitric oxide and relaxin, affecting both systolic and diastolic components. In the third trimester, diastolic pressure gradually rises and may normalize to baseline values at term. Another important aspect of the cardiovascular status in pregnancy relates to hemostatic changes, which lead to hypercoagulability via an increase in concentration of coagulation factors, fibrinogen, and","downloadable_attachments":[{"id":40469252,"asset_id":19169342,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":24274079,"first_name":"Antonis","last_name":"Manolis","domain_name":"uoa","page_name":"AM","display_name":"Antonis Manolis","profile_url":"https://uoa.academia.edu/AM?f_ri=31958","photo":"https://0.academia-photos.com/24274079/51142592/39201964/s65_antonis.manolis.jpg"}],"research_interests":[{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":38676,"name":"Anxiety","url":"https://www.academia.edu/Documents/in/Anxiety?f_ri=31958","nofollow":true},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=31958","nofollow":true},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=31958"},{"id":89995,"name":"Diuretics","url":"https://www.academia.edu/Documents/in/Diuretics?f_ri=31958"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=31958"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":323090,"name":"Cardiac Arrhythmias","url":"https://www.academia.edu/Documents/in/Cardiac_Arrhythmias?f_ri=31958"},{"id":380006,"name":"Rest","url":"https://www.academia.edu/Documents/in/Rest?f_ri=31958"},{"id":410370,"name":"Public health 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major</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27429051" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="853d04539a7c5324c30a2511f5f1ae7f" rel="nofollow" data-download="{"attachment_id":47687159,"asset_id":27429051,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47687159/download_file?st=MTczOTgwNTU3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i 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InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="27429051"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27429051; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27429051]").text(description); $(".js-view-count-work_27429051").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27429051").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27429051"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="46824" rel="nofollow" href="https://www.academia.edu/Documents/in/Echocardiography">Echocardiography</a>, <script data-card-contents-for-ri="46824" 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Dysfunction","url":"https://www.academia.edu/Documents/in/Left_Ventricular_Dysfunction?f_ri=31958"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=31958"},{"id":426578,"name":"Cardiac Output Monitoring","url":"https://www.academia.edu/Documents/in/Cardiac_Output_Monitoring?f_ri=31958"},{"id":627890,"name":"Blood Transfusion","url":"https://www.academia.edu/Documents/in/Blood_Transfusion?f_ri=31958"},{"id":979424,"name":"Beta Thalassemia","url":"https://www.academia.edu/Documents/in/Beta_Thalassemia?f_ri=31958"},{"id":1154249,"name":"Heart Ventricles","url":"https://www.academia.edu/Documents/in/Heart_Ventricles?f_ri=31958"},{"id":2207328,"name":"Heart Diseases","url":"https://www.academia.edu/Documents/in/Heart_Diseases?f_ri=31958"},{"id":2397637,"name":"Deferoxamine","url":"https://www.academia.edu/Documents/in/Deferoxamine?f_ri=31958"},{"id":2397638,"name":"Thalassemia Major","url":"https://www.academia.edu/Documents/in/Thalassemia_Major?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24823317" data-work_id="24823317" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24823317/Long_Term_Outcome_of_Lung_and_Heart_Lung_Transplantation_for_Idiopathic_Pulmonary_Arterial_Hypertension">Long-Term Outcome of Lung and Heart-Lung Transplantation for Idiopathic Pulmonary Arterial Hypertension</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Background. The survival after lung and heart-lung transplantation for idiopathic pulmonary arterial hypertension has been reportedly the lowest among the major diagnostic categories of lung transplant recipients.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24823317" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0593754e3df2bfb94d0b352567518ab3" rel="nofollow" data-download="{"attachment_id":45148588,"asset_id":24823317,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45148588/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="20735473" href="https://usna.academia.edu/BruceJohnson">Bruce Johnson</a><script data-card-contents-for-user="20735473" type="text/json">{"id":20735473,"first_name":"Bruce","last_name":"Johnson","domain_name":"usna","page_name":"BruceJohnson","display_name":"Bruce Johnson","profile_url":"https://usna.academia.edu/BruceJohnson?f_ri=31958","photo":"https://0.academia-photos.com/20735473/5737692/6523939/s65_bruce.johnson.jpg"}</script></span></span></li><li class="js-paper-rank-work_24823317 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24823317"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24823317, container: ".js-paper-rank-work_24823317", }); 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$(".js-view-count[data-work-id=24823317]").text(description); $(".js-view-count-work_24823317").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24823317").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24823317"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">27</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="647" rel="nofollow" href="https://www.academia.edu/Documents/in/Surgery">Surgery</a>, <script data-card-contents-for-ri="647" type="text/json">{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8942" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment">Treatment</a>, <script data-card-contents-for-ri="8942" type="text/json">{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10882" rel="nofollow" href="https://www.academia.edu/Documents/in/Evolution">Evolution</a><script data-card-contents-for-ri="10882" type="text/json">{"id":10882,"name":"Evolution","url":"https://www.academia.edu/Documents/in/Evolution?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24823317]'), work: {"id":24823317,"title":"Long-Term Outcome of Lung and Heart-Lung Transplantation for Idiopathic Pulmonary Arterial Hypertension","created_at":"2016-04-27T15:55:25.035-07:00","url":"https://www.academia.edu/24823317/Long_Term_Outcome_of_Lung_and_Heart_Lung_Transplantation_for_Idiopathic_Pulmonary_Arterial_Hypertension?f_ri=31958","dom_id":"work_24823317","summary":"Background. The survival after lung and heart-lung transplantation for idiopathic pulmonary arterial hypertension has been reportedly the lowest among the major diagnostic categories of lung transplant recipients.","downloadable_attachments":[{"id":45148588,"asset_id":24823317,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":20735473,"first_name":"Bruce","last_name":"Johnson","domain_name":"usna","page_name":"BruceJohnson","display_name":"Bruce Johnson","profile_url":"https://usna.academia.edu/BruceJohnson?f_ri=31958","photo":"https://0.academia-photos.com/20735473/5737692/6523939/s65_bruce.johnson.jpg"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=31958","nofollow":true},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=31958","nofollow":true},{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment?f_ri=31958","nofollow":true},{"id":10882,"name":"Evolution","url":"https://www.academia.edu/Documents/in/Evolution?f_ri=31958","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=31958"},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=31958"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958"},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958"},{"id":33069,"name":"Probability","url":"https://www.academia.edu/Documents/in/Probability?f_ri=31958"},{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=31958"},{"id":129739,"name":"Anesthesia","url":"https://www.academia.edu/Documents/in/Anesthesia?f_ri=31958"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=31958"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=31958"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=31958"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=31958"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance?f_ri=31958"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=31958"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=31958"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=31958"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=31958"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=31958"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=31958"},{"id":908385,"name":"Long Term","url":"https://www.academia.edu/Documents/in/Long_Term?f_ri=31958"},{"id":1036494,"name":"Heart and Lung Transplantation","url":"https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation?f_ri=31958"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models?f_ri=31958"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13869605" data-work_id="13869605" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13869605/Effects_of_multikinase_inhibitors_on_pressure_overload_induced_right_ventricular_remodeling">Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Little is known about the effects of current PAH therapies and receptor tyrosine kinase inhibitors on heart remodeling. We sought to investigate the effects of the multikinase inhibitors sunitinib (PDGFR-, VEGFR-and KIT-inhibitor) and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13869605" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Little is known about the effects of current PAH therapies and receptor tyrosine kinase inhibitors on heart remodeling. We sought to investigate the effects of the multikinase inhibitors sunitinib (PDGFR-, VEGFR-and KIT-inhibitor) and sorafenib (raf1/b-, VEGFR-, PDGFR-inhibitor) on pressure overload induced right ventricular (RV) remodeling. Methods: We investigated the effects of the kinase inhibitors on hemodynamics and remodeling in rats subjected either to monocrotaline (MCT)-induced PH or to surgical pulmonary artery banding (PAB). MCT rats were treated from days 21 to 35 with either vehicle, sunitinib (1 mg/kg, 5 mg/kg and 10 mg/kg/day) or sorafenib (10 mg/kg/day). PAB rats were treated with vehicle, sunitinib (10 mg/kg/day) or sorafenib (10 mg/kg/day) from days 7 to 21. RV function and remodeling were determined using echocardiography, invasive hemodynamic measurement and histomorphometry. Results: Treatment with both sorafenib and sunitinib decreased right ventricular systolic pressure, pulmonary vascular remodeling, RV hypertrophy and fibrosis in MCT rats. This was associated with an improvement of RV function. Importantly, after PAB, both compounds reversed RV chamber and cellular hypertrophy, reduced RV interstitial and perivascular fibrosis, and improved RV function. Conclusion: We demonstrated that sunitinib and sorafenib reversed RV remodeling and significantly improved RV function measured via a range of invasive and non-invasive cardiopulmonary endpoints in experimental models of RV hypertrophy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13869605" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fc554fb77f7733d10f61a20a4878614f" rel="nofollow" data-download="{"attachment_id":44858569,"asset_id":13869605,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44858569/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32953854" href="https://jlu-giessen.academia.edu/AkylbekSydykov">Akylbek Sydykov</a><script data-card-contents-for-user="32953854" type="text/json">{"id":32953854,"first_name":"Akylbek","last_name":"Sydykov","domain_name":"jlu-giessen","page_name":"AkylbekSydykov","display_name":"Akylbek Sydykov","profile_url":"https://jlu-giessen.academia.edu/AkylbekSydykov?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13869605 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13869605"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13869605, container: ".js-paper-rank-work_13869605", }); });</script></li><li class="js-percentile-work_13869605 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13869605; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13869605"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13869605 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13869605"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13869605; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13869605]").text(description); $(".js-view-count-work_13869605").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13869605").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13869605"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9334" rel="nofollow" href="https://www.academia.edu/Documents/in/Inflammation">Inflammation</a>, <script data-card-contents-for-ri="9334" type="text/json">{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13869605]'), work: {"id":13869605,"title":"Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling","created_at":"2015-07-10T01:11:19.883-07:00","url":"https://www.academia.edu/13869605/Effects_of_multikinase_inhibitors_on_pressure_overload_induced_right_ventricular_remodeling?f_ri=31958","dom_id":"work_13869605","summary":"Little is known about the effects of current PAH therapies and receptor tyrosine kinase inhibitors on heart remodeling. We sought to investigate the effects of the multikinase inhibitors sunitinib (PDGFR-, VEGFR-and KIT-inhibitor) and sorafenib (raf1/b-, VEGFR-, PDGFR-inhibitor) on pressure overload induced right ventricular (RV) remodeling. Methods: We investigated the effects of the kinase inhibitors on hemodynamics and remodeling in rats subjected either to monocrotaline (MCT)-induced PH or to surgical pulmonary artery banding (PAB). MCT rats were treated from days 21 to 35 with either vehicle, sunitinib (1 mg/kg, 5 mg/kg and 10 mg/kg/day) or sorafenib (10 mg/kg/day). PAB rats were treated with vehicle, sunitinib (10 mg/kg/day) or sorafenib (10 mg/kg/day) from days 7 to 21. RV function and remodeling were determined using echocardiography, invasive hemodynamic measurement and histomorphometry. Results: Treatment with both sorafenib and sunitinib decreased right ventricular systolic pressure, pulmonary vascular remodeling, RV hypertrophy and fibrosis in MCT rats. This was associated with an improvement of RV function. Importantly, after PAB, both compounds reversed RV chamber and cellular hypertrophy, reduced RV interstitial and perivascular fibrosis, and improved RV function. Conclusion: We demonstrated that sunitinib and sorafenib reversed RV remodeling and significantly improved RV function measured via a range of invasive and non-invasive cardiopulmonary endpoints in experimental models of RV hypertrophy.","downloadable_attachments":[{"id":44858569,"asset_id":13869605,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32953854,"first_name":"Akylbek","last_name":"Sydykov","domain_name":"jlu-giessen","page_name":"AkylbekSydykov","display_name":"Akylbek Sydykov","profile_url":"https://jlu-giessen.academia.edu/AkylbekSydykov?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=31958","nofollow":true},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958","nofollow":true},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=31958"},{"id":803294,"name":"Ventricular Remodeling","url":"https://www.academia.edu/Documents/in/Ventricular_Remodeling?f_ri=31958"},{"id":1343089,"name":"Protein Kinase Inhibitors","url":"https://www.academia.edu/Documents/in/Protein_Kinase_Inhibitors?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20938544" data-work_id="20938544" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20938544/Pulmonary_Hypertension_Bronchoscopy_and_the_Big_Bad_Wolf_An_Overestimated_Risk_Factor">Pulmonary Hypertension, Bronchoscopy and the Big Bad Wolf! An Overestimated Risk Factor?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">contraindication for FB. Evaluation of the risk that this condition represents for bronchoscopic procedures relies by necessity only on the experts' opinion .</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20938544" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="276ac13ee947088fb9741c7b54e73c8a" rel="nofollow" data-download="{"attachment_id":41637192,"asset_id":20938544,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41637192/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="7629744" href="https://uoa.academia.edu/GrigorisStratakos">Grigoris Stratakos</a><script data-card-contents-for-user="7629744" type="text/json">{"id":7629744,"first_name":"Grigoris","last_name":"Stratakos","domain_name":"uoa","page_name":"GrigorisStratakos","display_name":"Grigoris Stratakos","profile_url":"https://uoa.academia.edu/GrigorisStratakos?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_20938544 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20938544"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20938544, container: ".js-paper-rank-work_20938544", }); });</script></li><li class="js-percentile-work_20938544 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20938544; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_20938544"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_20938544 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="20938544"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20938544; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20938544]").text(description); $(".js-view-count-work_20938544").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20938544").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20938544"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="192721" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk_factors">Risk factors</a>, <script data-card-contents-for-ri="192721" type="text/json">{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="202428" rel="nofollow" href="https://www.academia.edu/Documents/in/Respiration">Respiration</a>, <script data-card-contents-for-ri="202428" type="text/json">{"id":202428,"name":"Respiration","url":"https://www.academia.edu/Documents/in/Respiration?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="466476" rel="nofollow" href="https://www.academia.edu/Documents/in/Bronchoscopy">Bronchoscopy</a><script data-card-contents-for-ri="466476" type="text/json">{"id":466476,"name":"Bronchoscopy","url":"https://www.academia.edu/Documents/in/Bronchoscopy?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20938544]'), work: {"id":20938544,"title":"Pulmonary Hypertension, Bronchoscopy and the Big Bad Wolf! An Overestimated Risk Factor?","created_at":"2016-01-27T06:17:04.867-08:00","url":"https://www.academia.edu/20938544/Pulmonary_Hypertension_Bronchoscopy_and_the_Big_Bad_Wolf_An_Overestimated_Risk_Factor?f_ri=31958","dom_id":"work_20938544","summary":"contraindication for FB. Evaluation of the risk that this condition represents for bronchoscopic procedures relies by necessity only on the experts' opinion .","downloadable_attachments":[{"id":41637192,"asset_id":20938544,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":7629744,"first_name":"Grigoris","last_name":"Stratakos","domain_name":"uoa","page_name":"GrigorisStratakos","display_name":"Grigoris Stratakos","profile_url":"https://uoa.academia.edu/GrigorisStratakos?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=31958","nofollow":true},{"id":202428,"name":"Respiration","url":"https://www.academia.edu/Documents/in/Respiration?f_ri=31958","nofollow":true},{"id":466476,"name":"Bronchoscopy","url":"https://www.academia.edu/Documents/in/Bronchoscopy?f_ri=31958","nofollow":true},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_4405032" data-work_id="4405032" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/4405032/Fatal_Fat_Embolism_after_Vertebroplasty_Identification_of_the_High_Risk_Patient">Fatal Fat Embolism after Vertebroplasty: Identification of the High-Risk Patient</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We report a rare complication of autopsy-proven fat and bone marrow embolization following percutaneous vertebroplasty in a patient who had no evidence of cement leakage. Cement injection was done during one patient encounter, covering 3... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_4405032" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We report a rare complication of autopsy-proven fat and bone marrow embolization following percutaneous vertebroplasty in a patient who had no evidence of cement leakage. Cement injection was done during one patient encounter, covering 3 vertebral levels by using a unipedicular approach. Patients may have complications even without polymethylmethacrylate leakage.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4405032" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c00093c80d1fcb677b8d461ab20911b6" rel="nofollow" data-download="{"attachment_id":31832378,"asset_id":4405032,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/31832378/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5401727" href="https://oxford.academia.edu/AzimShaikh">Azim Shaikh</a><script data-card-contents-for-user="5401727" type="text/json">{"id":5401727,"first_name":"Azim","last_name":"Shaikh","domain_name":"oxford","page_name":"AzimShaikh","display_name":"Azim Shaikh","profile_url":"https://oxford.academia.edu/AzimShaikh?f_ri=31958","photo":"https://0.academia-photos.com/5401727/2371840/2763183/s65_azim.shaikh.jpg"}</script></span></span></li><li class="js-paper-rank-work_4405032 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="4405032"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 4405032, container: ".js-paper-rank-work_4405032", }); });</script></li><li class="js-percentile-work_4405032 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4405032; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_4405032"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_4405032 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="4405032"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4405032; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4405032]").text(description); $(".js-view-count-work_4405032").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_4405032").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="4405032"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="102587" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Embolism">Pulmonary Embolism</a>, <script data-card-contents-for-ri="102587" type="text/json">{"id":102587,"name":"Pulmonary Embolism","url":"https://www.academia.edu/Documents/in/Pulmonary_Embolism?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="192721" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk_factors">Risk factors</a>, <script data-card-contents-for-ri="192721" type="text/json">{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=4405032]'), work: {"id":4405032,"title":"Fatal Fat Embolism after Vertebroplasty: Identification of the High-Risk Patient","created_at":"2013-09-04T01:53:41.376-07:00","url":"https://www.academia.edu/4405032/Fatal_Fat_Embolism_after_Vertebroplasty_Identification_of_the_High_Risk_Patient?f_ri=31958","dom_id":"work_4405032","summary":"We report a rare complication of autopsy-proven fat and bone marrow embolization following percutaneous vertebroplasty in a patient who had no evidence of cement leakage. Cement injection was done during one patient encounter, covering 3 vertebral levels by using a unipedicular approach. Patients may have complications even without polymethylmethacrylate leakage.","downloadable_attachments":[{"id":31832378,"asset_id":4405032,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5401727,"first_name":"Azim","last_name":"Shaikh","domain_name":"oxford","page_name":"AzimShaikh","display_name":"Azim Shaikh","profile_url":"https://oxford.academia.edu/AzimShaikh?f_ri=31958","photo":"https://0.academia-photos.com/5401727/2371840/2763183/s65_azim.shaikh.jpg"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":102587,"name":"Pulmonary Embolism","url":"https://www.academia.edu/Documents/in/Pulmonary_Embolism?f_ri=31958","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=31958","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=31958"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=31958"},{"id":963201,"name":"Thoracic Vertebrae","url":"https://www.academia.edu/Documents/in/Thoracic_Vertebrae?f_ri=31958"},{"id":1161733,"name":"Ambulatory Surgical Procedures","url":"https://www.academia.edu/Documents/in/Ambulatory_Surgical_Procedures?f_ri=31958"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=31958"},{"id":2112668,"name":"Spinal fractures","url":"https://www.academia.edu/Documents/in/Spinal_fractures?f_ri=31958"},{"id":2369445,"name":"Pulmonary Artery","url":"https://www.academia.edu/Documents/in/Pulmonary_Artery?f_ri=31958"},{"id":2463621,"name":"Postoperative Complications","url":"https://www.academia.edu/Documents/in/Postoperative_Complications?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16054995" data-work_id="16054995" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16054995/Pulmonary_and_systemic_arterial_pressure_in_hyaline_membrane_disease">Pulmonary and systemic arterial pressure in hyaline membrane disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Systolic pulmonary arterial pressure was determined serialiy over the first 10 days of life in 33 babies with hyaline membrane disease by measuring the peak velocity of pansystolic tricuspid valve regurgitation, using Doppler ultrasound,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16054995" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Systolic pulmonary arterial pressure was determined serialiy over the first 10 days of life in 33 babies with hyaline membrane disease by measuring the peak velocity of pansystolic tricuspid valve regurgitation, using Doppler ultrasound, and applying the Bernoulli equation. Results are presented in age groups 0-12, 13-36, 37-72, and 73-96 hours respectively. The incidence of tricuspid valve regurgitation was 92, 97, 80, and 64% (falling to 35% by day 10) compared with 53, 50, 31, and 0% in 17 healthy premature infants.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16054995" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c5409618c29217125f8fde4d014cb1e7" rel="nofollow" data-download="{"attachment_id":42767103,"asset_id":16054995,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42767103/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35187492" href="https://independent.academia.edu/RichardBoys">Richard Boys</a><script data-card-contents-for-user="35187492" type="text/json">{"id":35187492,"first_name":"Richard","last_name":"Boys","domain_name":"independent","page_name":"RichardBoys","display_name":"Richard Boys","profile_url":"https://independent.academia.edu/RichardBoys?f_ri=31958","photo":"https://0.academia-photos.com/35187492/19171339/19117342/s65_richard.boys.jpg"}</script></span></span></li><li class="js-paper-rank-work_16054995 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16054995"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16054995, container: ".js-paper-rank-work_16054995", }); });</script></li><li class="js-percentile-work_16054995 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16054995; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16054995"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16054995 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16054995"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16054995; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16054995]").text(description); $(".js-view-count-work_16054995").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16054995").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16054995"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4594" rel="nofollow" href="https://www.academia.edu/Documents/in/Carbon_Dioxide">Carbon Dioxide</a>, <script data-card-contents-for-ri="4594" type="text/json">{"id":4594,"name":"Carbon Dioxide","url":"https://www.academia.edu/Documents/in/Carbon_Dioxide?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52112" rel="nofollow" href="https://www.academia.edu/Documents/in/Hyaline_membrane_disease">Hyaline membrane disease</a>, <script data-card-contents-for-ri="52112" type="text/json">{"id":52112,"name":"Hyaline membrane disease","url":"https://www.academia.edu/Documents/in/Hyaline_membrane_disease?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="71935" rel="nofollow" href="https://www.academia.edu/Documents/in/Doppler_Ultrasound">Doppler Ultrasound</a><script data-card-contents-for-ri="71935" type="text/json">{"id":71935,"name":"Doppler Ultrasound","url":"https://www.academia.edu/Documents/in/Doppler_Ultrasound?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16054995]'), work: {"id":16054995,"title":"Pulmonary and systemic arterial pressure in hyaline membrane disease","created_at":"2015-09-22T18:36:12.442-07:00","url":"https://www.academia.edu/16054995/Pulmonary_and_systemic_arterial_pressure_in_hyaline_membrane_disease?f_ri=31958","dom_id":"work_16054995","summary":"Systolic pulmonary arterial pressure was determined serialiy over the first 10 days of life in 33 babies with hyaline membrane disease by measuring the peak velocity of pansystolic tricuspid valve regurgitation, using Doppler ultrasound, and applying the Bernoulli equation. Results are presented in age groups 0-12, 13-36, 37-72, and 73-96 hours respectively. The incidence of tricuspid valve regurgitation was 92, 97, 80, and 64% (falling to 35% by day 10) compared with 53, 50, 31, and 0% in 17 healthy premature infants.","downloadable_attachments":[{"id":42767103,"asset_id":16054995,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35187492,"first_name":"Richard","last_name":"Boys","domain_name":"independent","page_name":"RichardBoys","display_name":"Richard Boys","profile_url":"https://independent.academia.edu/RichardBoys?f_ri=31958","photo":"https://0.academia-photos.com/35187492/19171339/19117342/s65_richard.boys.jpg"}],"research_interests":[{"id":4594,"name":"Carbon Dioxide","url":"https://www.academia.edu/Documents/in/Carbon_Dioxide?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":52112,"name":"Hyaline membrane disease","url":"https://www.academia.edu/Documents/in/Hyaline_membrane_disease?f_ri=31958","nofollow":true},{"id":71935,"name":"Doppler Ultrasound","url":"https://www.academia.edu/Documents/in/Doppler_Ultrasound?f_ri=31958","nofollow":true},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=31958"},{"id":137946,"name":"Disease Severity","url":"https://www.academia.edu/Documents/in/Disease_Severity?f_ri=31958"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=31958"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=31958"},{"id":797418,"name":"Gestational Age","url":"https://www.academia.edu/Documents/in/Gestational_Age?f_ri=31958"},{"id":1015729,"name":"Ct Image of Pulmonary Artery","url":"https://www.academia.edu/Documents/in/Ct_Image_of_Pulmonary_Artery?f_ri=31958"},{"id":1157501,"name":"Blood Flow Velocity","url":"https://www.academia.edu/Documents/in/Blood_Flow_Velocity?f_ri=31958"},{"id":1312781,"name":"Temporal Variability","url":"https://www.academia.edu/Documents/in/Temporal_Variability?f_ri=31958"},{"id":1470936,"name":"Age Groups","url":"https://www.academia.edu/Documents/in/Age_Groups?f_ri=31958"},{"id":2369445,"name":"Pulmonary Artery","url":"https://www.academia.edu/Documents/in/Pulmonary_Artery?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24395977" data-work_id="24395977" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24395977/Effects_of_beraprost_sodium_an_oral_prostacyclin_analogue_in_patients_with_pulmonary_arterial_hypertension_a_randomized_double_blind_placebo_controlled_trial">Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The purpose of this study was to assess the efficacy and safety of beraprost sodium, an orally active prostacyclin analogue, in New York Heart Association (NYHA) functional class II and III patients with pulmonary arterial hypertension... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24395977" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The purpose of this study was to assess the efficacy and safety of beraprost sodium, an orally active prostacyclin analogue, in New York Heart Association (NYHA) functional class II and III patients with pulmonary arterial hypertension (PAH). BACKGROUND Pulmonary arterial hypertension is a life-threatening disease for which continuous intravenous infusion of prostacyclin has been proven effective. However, this treatment is associated with serious complications arising from the complex delivery system.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24395977" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="42bde5b210b7d6f6359ffc2d6181b0ba" rel="nofollow" data-download="{"attachment_id":44728567,"asset_id":24395977,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44728567/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="47036324" href="https://independent.academia.edu/Sitbon">O. Sitbon</a><script data-card-contents-for-user="47036324" type="text/json">{"id":47036324,"first_name":"O.","last_name":"Sitbon","domain_name":"independent","page_name":"Sitbon","display_name":"O. Sitbon","profile_url":"https://independent.academia.edu/Sitbon?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24395977 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24395977"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24395977, container: ".js-paper-rank-work_24395977", }); });</script></li><li class="js-percentile-work_24395977 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24395977; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24395977"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24395977 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24395977"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24395977; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24395977]").text(description); $(".js-view-count-work_24395977").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24395977").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24395977"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22997" rel="nofollow" href="https://www.academia.edu/Documents/in/Arterial_hypertension">Arterial hypertension</a>, <script data-card-contents-for-ri="22997" type="text/json">{"id":22997,"name":"Arterial hypertension","url":"https://www.academia.edu/Documents/in/Arterial_hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a><script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24395977]'), work: {"id":24395977,"title":"Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial","created_at":"2016-04-14T06:31:26.252-07:00","url":"https://www.academia.edu/24395977/Effects_of_beraprost_sodium_an_oral_prostacyclin_analogue_in_patients_with_pulmonary_arterial_hypertension_a_randomized_double_blind_placebo_controlled_trial?f_ri=31958","dom_id":"work_24395977","summary":"The purpose of this study was to assess the efficacy and safety of beraprost sodium, an orally active prostacyclin analogue, in New York Heart Association (NYHA) functional class II and III patients with pulmonary arterial hypertension (PAH). BACKGROUND Pulmonary arterial hypertension is a life-threatening disease for which continuous intravenous infusion of prostacyclin has been proven effective. However, this treatment is associated with serious complications arising from the complex delivery system.","downloadable_attachments":[{"id":44728567,"asset_id":24395977,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":47036324,"first_name":"O.","last_name":"Sitbon","domain_name":"independent","page_name":"Sitbon","display_name":"O. Sitbon","profile_url":"https://independent.academia.edu/Sitbon?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=31958","nofollow":true},{"id":22997,"name":"Arterial hypertension","url":"https://www.academia.edu/Documents/in/Arterial_hypertension?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=31958","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=31958"},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=31958"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The?f_ri=31958"},{"id":164831,"name":"Dyspnea","url":"https://www.academia.edu/Documents/in/Dyspnea?f_ri=31958"},{"id":194055,"name":"Randomised Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomised_Controlled_Trial?f_ri=31958"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=31958"},{"id":1210716,"name":"Exercise Tolerance","url":"https://www.academia.edu/Documents/in/Exercise_Tolerance?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22220284" data-work_id="22220284" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22220284/Methemoglobin_formation_in_children_with_congenital_heart_disease_treated_with_inhaled_nitric_oxide_after_cardiac_surgery">Methemoglobin formation in children with congenital heart disease treated with inhaled nitric oxide after cardiac surgery</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Inhaled nitric oxide (NO) is used as a therapy of pulmonary hypertension in children after cardiac surgery. Hemoglobin binds to NO with great affinity and forms methemoglobin by oxidation in the erythrocyte. Once produced, methemoglobin... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22220284" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Inhaled nitric oxide (NO) is used as a therapy of pulmonary hypertension in children after cardiac surgery. Hemoglobin binds to NO with great affinity and forms methemoglobin by oxidation in the erythrocyte. Once produced, methemoglobin is unable to transport and unload oxygen in the tissues. The amount of available hemoglobin in the body for oxygen transport is thereby reduced. Anemia, acidosis, respiratory compromise and cardiac disease may render patients more susceptible than expected for a given methemoglobin level. The goal of the present study was to review the cumulative effect of inhaled NO on methemoglobin formation in critically ill children. We therefore looked for methemoglobin levels in children with congenital heart disease after cardiac surgery who were treated with inhaled NO in a range of 5-40 ppm. We retrospectively reviewed the medical charts of 38 children with congenital heart disease after cardiac surgery. We extracted demographic data and physiological measur...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22220284" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="61d9274e1c8d13fd578cc30c16d30464" rel="nofollow" data-download="{"attachment_id":42872239,"asset_id":22220284,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42872239/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43582265" href="https://independent.academia.edu/GWollenek">G. Wollenek</a><script data-card-contents-for-user="43582265" type="text/json">{"id":43582265,"first_name":"G.","last_name":"Wollenek","domain_name":"independent","page_name":"GWollenek","display_name":"G. 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Hemoglobin binds to NO with great affinity and forms methemoglobin by oxidation in the erythrocyte. Once produced, methemoglobin is unable to transport and unload oxygen in the tissues. The amount of available hemoglobin in the body for oxygen transport is thereby reduced. Anemia, acidosis, respiratory compromise and cardiac disease may render patients more susceptible than expected for a given methemoglobin level. The goal of the present study was to review the cumulative effect of inhaled NO on methemoglobin formation in critically ill children. We therefore looked for methemoglobin levels in children with congenital heart disease after cardiac surgery who were treated with inhaled NO in a range of 5-40 ppm. We retrospectively reviewed the medical charts of 38 children with congenital heart disease after cardiac surgery. We extracted demographic data and physiological measur...","downloadable_attachments":[{"id":42872239,"asset_id":22220284,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43582265,"first_name":"G.","last_name":"Wollenek","domain_name":"independent","page_name":"GWollenek","display_name":"G. Wollenek","profile_url":"https://independent.academia.edu/GWollenek?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":39851,"name":"Cardiac Surgery","url":"https://www.academia.edu/Documents/in/Cardiac_Surgery?f_ri=31958","nofollow":true},{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects?f_ri=31958","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=31958","nofollow":true},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=31958"},{"id":94234,"name":"INTENSIVE CARE","url":"https://www.academia.edu/Documents/in/INTENSIVE_CARE?f_ri=31958"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":306949,"name":"Oxygen Transport","url":"https://www.academia.edu/Documents/in/Oxygen_Transport?f_ri=31958"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=31958"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance?f_ri=31958"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=31958"},{"id":568312,"name":"Intensive Care Medicine","url":"https://www.academia.edu/Documents/in/Intensive_Care_Medicine?f_ri=31958"},{"id":571425,"name":"Oximetry","url":"https://www.academia.edu/Documents/in/Oximetry?f_ri=31958"},{"id":735030,"name":"Congenital Heart Disease","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Disease?f_ri=31958"},{"id":1225893,"name":"Effective Dose","url":"https://www.academia.edu/Documents/in/Effective_Dose?f_ri=31958"},{"id":1309032,"name":"Cardiac Disease","url":"https://www.academia.edu/Documents/in/Cardiac_Disease?f_ri=31958"},{"id":1993786,"name":"Cumulant","url":"https://www.academia.edu/Documents/in/Cumulant?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18789385 coauthored" data-work_id="18789385" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18789385/Pulmonary_arterial_hypertension_in_congenital_heart_disease_An_epidemiologic_perspective_from_a_Dutch_registry">Pulmonary arterial hypertension in congenital heart disease: An epidemiologic perspective from a Dutch registry</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18789385" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e733831032225e51efa10ecebcd3b2dd" rel="nofollow" data-download="{"attachment_id":40255918,"asset_id":18789385,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40255918/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38869969" href="https://independent.academia.edu/PaulBresser">Paul Bresser</a><script data-card-contents-for-user="38869969" type="text/json">{"id":38869969,"first_name":"Paul","last_name":"Bresser","domain_name":"independent","page_name":"PaulBresser","display_name":"Paul Bresser","profile_url":"https://independent.academia.edu/PaulBresser?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-18789385">+1</span><div class="hidden js-additional-users-18789385"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/ElkeHoendermis">Elke Hoendermis</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-18789385'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-18789385').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_18789385 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18789385"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18789385, container: ".js-paper-rank-work_18789385", }); });</script></li><li class="js-percentile-work_18789385 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 18789385; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_18789385"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_18789385 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="18789385"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 18789385; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=18789385]").text(description); $(".js-view-count-work_18789385").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18789385").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18789385"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22997" rel="nofollow" href="https://www.academia.edu/Documents/in/Arterial_hypertension">Arterial hypertension</a>, <script data-card-contents-for-ri="22997" type="text/json">{"id":22997,"name":"Arterial hypertension","url":"https://www.academia.edu/Documents/in/Arterial_hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a><script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18789385]'), work: {"id":18789385,"title":"Pulmonary arterial hypertension in congenital heart disease: An epidemiologic perspective from a Dutch registry","created_at":"2015-11-22T01:56:13.951-08:00","url":"https://www.academia.edu/18789385/Pulmonary_arterial_hypertension_in_congenital_heart_disease_An_epidemiologic_perspective_from_a_Dutch_registry?f_ri=31958","dom_id":"work_18789385","summary":null,"downloadable_attachments":[{"id":40255918,"asset_id":18789385,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38869969,"first_name":"Paul","last_name":"Bresser","domain_name":"independent","page_name":"PaulBresser","display_name":"Paul Bresser","profile_url":"https://independent.academia.edu/PaulBresser?f_ri=31958","photo":"/images/s65_no_pic.png"},{"id":58675789,"first_name":"Elke","last_name":"Hoendermis","domain_name":"independent","page_name":"ElkeHoendermis","display_name":"Elke Hoendermis","profile_url":"https://independent.academia.edu/ElkeHoendermis?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=31958","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=31958","nofollow":true},{"id":22997,"name":"Arterial hypertension","url":"https://www.academia.edu/Documents/in/Arterial_hypertension?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=31958"},{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects?f_ri=31958"},{"id":157892,"name":"Netherlands","url":"https://www.academia.edu/Documents/in/Netherlands?f_ri=31958"},{"id":209856,"name":"Registries","url":"https://www.academia.edu/Documents/in/Registries?f_ri=31958"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=31958"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=31958"},{"id":437772,"name":"Odds ratio","url":"https://www.academia.edu/Documents/in/Odds_ratio?f_ri=31958"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=31958"},{"id":735030,"name":"Congenital Heart Disease","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Disease?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14610053 coauthored" data-work_id="14610053" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14610053/Denys_Drash_syndrome_and_congenital_diaphragmatic_hernia_Another_case_with_the_1097G_A_Arg366His_mutation">Denys–Drash syndrome and congenital diaphragmatic hernia: Another case with the 1097G > A(Arg366His) mutation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Congenital diaphragmatic hernia (CDH) is a disorder of the development of the lung and diaphragm and is associated with pulmonary hypoplasia and pulmonary hypertension. Denys-Drash syndrome (DDS) is a well-known syndrome caused by several... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14610053" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Congenital diaphragmatic hernia (CDH) is a disorder of the development of the lung and diaphragm and is associated with pulmonary hypoplasia and pulmonary hypertension. Denys-Drash syndrome (DDS) is a well-known syndrome caused by several different germline mutations in the WT1gene. CDH in DDS is rare. We present the third case of CDH with clinical features of DDS and the same, rare Arg366His mutation in the WT1-gene, as reported in the other two known cases. This report provides additional evidence that WT1 mutations can result in diaphragmatic hernia.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14610053" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="07ff37d57192620a3603460c44699cc7" rel="nofollow" data-download="{"attachment_id":44037216,"asset_id":14610053,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44037216/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35129417" href="https://independent.academia.edu/TimothyAntonius">Timothy Antonius</a><script data-card-contents-for-user="35129417" type="text/json">{"id":35129417,"first_name":"Timothy","last_name":"Antonius","domain_name":"independent","page_name":"TimothyAntonius","display_name":"Timothy Antonius","profile_url":"https://independent.academia.edu/TimothyAntonius?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-14610053">+2</span><div class="hidden js-additional-users-14610053"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://radboudumc.academia.edu/ArnoVanHeijst">Arno Van Heijst</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/KeesNoordam">Kees Noordam</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-14610053'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-14610053').html(); 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Denys-Drash syndrome (DDS) is a well-known syndrome caused by several different germline mutations in the WT1gene. CDH in DDS is rare. We present the third case of CDH with clinical features of DDS and the same, rare Arg366His mutation in the WT1-gene, as reported in the other two known cases. This report provides additional evidence that WT1 mutations can result in diaphragmatic hernia.","downloadable_attachments":[{"id":44037216,"asset_id":14610053,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35129417,"first_name":"Timothy","last_name":"Antonius","domain_name":"independent","page_name":"TimothyAntonius","display_name":"Timothy Antonius","profile_url":"https://independent.academia.edu/TimothyAntonius?f_ri=31958","photo":"/images/s65_no_pic.png"},{"id":33554934,"first_name":"Arno Van","last_name":"Heijst","domain_name":"radboudumc","page_name":"ArnoVanHeijst","display_name":"Arno Van Heijst","profile_url":"https://radboudumc.academia.edu/ArnoVanHeijst?f_ri=31958","photo":"https://0.academia-photos.com/33554934/17597798/17654712/s65_arno_van.heijst.jpg"},{"id":49557337,"first_name":"Kees","last_name":"Noordam","domain_name":"independent","page_name":"KeesNoordam","display_name":"Kees Noordam","profile_url":"https://independent.academia.edu/KeesNoordam?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=31958","nofollow":true},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American?f_ri=31958","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=31958"},{"id":371362,"name":"Chromosome","url":"https://www.academia.edu/Documents/in/Chromosome?f_ri=31958"},{"id":555120,"name":"Arginine","url":"https://www.academia.edu/Documents/in/Arginine?f_ri=31958"},{"id":579357,"name":"Congenital Diaphragmatic Hernia","url":"https://www.academia.edu/Documents/in/Congenital_Diaphragmatic_Hernia?f_ri=31958"},{"id":1365896,"name":"Histidine","url":"https://www.academia.edu/Documents/in/Histidine?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_52779432" data-work_id="52779432" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/52779432/Association_of_High_Blood_Pressure_with_Body_Mass_Index_Smoking_and_Physical_Activity_in_Healthy_Young_Adults">Association of High Blood Pressure with Body Mass Index, Smoking and Physical Activity in Healthy Young Adults</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Introduction: The purpose of this study was to examine the associations between resting blood pressure (BP), smoking, physical activity (PA) and body mass index (BMI) in Greek young adults. Materials and Methodology: A standardised... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_52779432" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Introduction: The purpose of this study was to examine the associations between resting blood pressure (BP), smoking, physical activity (PA) and body mass index (BMI) in Greek young adults. Materials and Methodology: A standardised questionnaire and the Greek version of IPAQ-short were given to 1500 randomly selected health science students, in order to record smoking behaviour, PA status, BMI and resting BP. All healthy young adults aged 19-30 years old were eligible. The final size of the study cohort was 1249 students (522 men). Results: Males’ BP was 129.2/77.0 mmHg, significantly higher than the females’ values of 119.9/73.4 mmHg. Approximately 17% of the total population were classified as overweight and 3% as obese. In the overall population, smoking prevalence was 35.2%, with 15.3% being heavy smokers (≥21 cigs/d). Smoking prevalence did not differ significantly between sexes. The prevalence of health-enhancing PA (high PAclass) was only 14.0%, while 42.8% of the study popul...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/52779432" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ace9831a24779d95e12c734593f193c3" rel="nofollow" data-download="{"attachment_id":69880035,"asset_id":52779432,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/69880035/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34144438" href="https://independent.academia.edu/MariaPapandreou">Maria Papandreou</a><script data-card-contents-for-user="34144438" type="text/json">{"id":34144438,"first_name":"Maria","last_name":"Papandreou","domain_name":"independent","page_name":"MariaPapandreou","display_name":"Maria Papandreou","profile_url":"https://independent.academia.edu/MariaPapandreou?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_52779432 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="52779432"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 52779432, container: ".js-paper-rank-work_52779432", }); 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$(".js-view-count[data-work-id=52779432]").text(description); $(".js-view-count-work_52779432").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_52779432").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="52779432"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9112" rel="nofollow" href="https://www.academia.edu/Documents/in/Physical_Activity">Physical Activity</a>, <script data-card-contents-for-ri="9112" type="text/json">{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22997" rel="nofollow" href="https://www.academia.edu/Documents/in/Arterial_hypertension">Arterial hypertension</a>, <script data-card-contents-for-ri="22997" type="text/json">{"id":22997,"name":"Arterial hypertension","url":"https://www.academia.edu/Documents/in/Arterial_hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="69367" rel="nofollow" href="https://www.academia.edu/Documents/in/Exercise_and_physical_activity_for_health">Exercise and physical activity for health</a><script data-card-contents-for-ri="69367" type="text/json">{"id":69367,"name":"Exercise and physical activity for health","url":"https://www.academia.edu/Documents/in/Exercise_and_physical_activity_for_health?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=52779432]'), work: {"id":52779432,"title":"Association of High Blood Pressure with Body Mass Index, Smoking and Physical Activity in Healthy Young Adults","created_at":"2021-09-18T23:09:43.406-07:00","url":"https://www.academia.edu/52779432/Association_of_High_Blood_Pressure_with_Body_Mass_Index_Smoking_and_Physical_Activity_in_Healthy_Young_Adults?f_ri=31958","dom_id":"work_52779432","summary":"Introduction: The purpose of this study was to examine the associations between resting blood pressure (BP), smoking, physical activity (PA) and body mass index (BMI) in Greek young adults. Materials and Methodology: A standardised questionnaire and the Greek version of IPAQ-short were given to 1500 randomly selected health science students, in order to record smoking behaviour, PA status, BMI and resting BP. All healthy young adults aged 19-30 years old were eligible. The final size of the study cohort was 1249 students (522 men). Results: Males’ BP was 129.2/77.0 mmHg, significantly higher than the females’ values of 119.9/73.4 mmHg. Approximately 17% of the total population were classified as overweight and 3% as obese. In the overall population, smoking prevalence was 35.2%, with 15.3% being heavy smokers (≥21 cigs/d). Smoking prevalence did not differ significantly between sexes. The prevalence of health-enhancing PA (high PAclass) was only 14.0%, while 42.8% of the study popul...","downloadable_attachments":[{"id":69880035,"asset_id":52779432,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34144438,"first_name":"Maria","last_name":"Papandreou","domain_name":"independent","page_name":"MariaPapandreou","display_name":"Maria Papandreou","profile_url":"https://independent.academia.edu/MariaPapandreou?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=31958","nofollow":true},{"id":22997,"name":"Arterial hypertension","url":"https://www.academia.edu/Documents/in/Arterial_hypertension?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":69367,"name":"Exercise and physical activity for health","url":"https://www.academia.edu/Documents/in/Exercise_and_physical_activity_for_health?f_ri=31958","nofollow":true},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension?f_ri=31958"},{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=31958"},{"id":76390,"name":"High Blood Pressure","url":"https://www.academia.edu/Documents/in/High_Blood_Pressure?f_ri=31958"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=31958"},{"id":112635,"name":"Smoking and Drug Rehabilitation","url":"https://www.academia.edu/Documents/in/Smoking_and_Drug_Rehabilitation?f_ri=31958"},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index?f_ri=31958"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=31958"},{"id":253318,"name":"Adapted Physical Activity","url":"https://www.academia.edu/Documents/in/Adapted_Physical_Activity?f_ri=31958"},{"id":295203,"name":"Hypertension Management","url":"https://www.academia.edu/Documents/in/Hypertension_Management?f_ri=31958"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=31958"},{"id":708755,"name":"Body Mass ındex","url":"https://www.academia.edu/Documents/in/Body_Mass_%C4%B1ndex?f_ri=31958"},{"id":790009,"name":"Hypertension treatment","url":"https://www.academia.edu/Documents/in/Hypertension_treatment?f_ri=31958"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_4075547" data-work_id="4075547" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/4075547/TERAPIA_INALAT%C3%93RIA_COM_%C3%93X%C3%8DDO_N%C3%8DTRICO_NA_HIPERTENS%C3%83O_PULMONAR_PERSISTENTE_DO_NEONATO_CUIDADO_DE_ENFERMAGEM_NITRIC_OXIDE_INHALATION_THERAPY_IN_PERSISTENT_PULMONARY_HYPERTENSION_AMONG_NEWBORNS_NURSING_CARE">TERAPIA INALATÓRIA COM ÓXÍDO NÍTRICO NA HIPERTENSÃO PULMONAR PERSISTENTE DO NEONATO: CUIDADO DE ENFERMAGEM NITRIC OXIDE INHALATION THERAPY IN PERSISTENT PULMONARY HYPERTENSION AMONG NEWBORNS: NURSING CARE</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">RESUMO: RESUMO: RESUMO: RESUMO: RESUMO: Este estudo trata de revisão bibliográfica sobre a utilização do óxido nítrico inalatório em neonatos acometidos de hipertensão pulmonar persistente. Objetiva enfocar os temas relacionados à sua... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_4075547" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">RESUMO: RESUMO: RESUMO: RESUMO: RESUMO: Este estudo trata de revisão bibliográfica sobre a utilização do óxido nítrico inalatório em neonatos acometidos de hipertensão pulmonar persistente. Objetiva enfocar os temas relacionados à sua administração e aos cuidados de enfermagem. Realizou-se a coleta de dados empíricos a partir das bases de dados MEDLINE, LILACS, BDENF, Biblioteca COCHRANE e vias não sistemáticas, no período de 1996 a 2003. As palavras-chave utilizadas foram: óxido nítrico, hipertensão pulmonar persistente, terapia intensiva neonatal, neonato, enfermagem neonatal e cuidados de enfermagem. Foram identificadas 190 publicações, 30 das quais se enquadravam nos objetivos da pesquisa. O estudo permitiu a organização do conhecimento produzido, possibilitando a apresentação dos dados em temas relacionados aos equipamentos de administração do óxido nítrico e às condutas ligadas à própria terapêutica, fornecendo subsídios teóricos para a sistematização da assistência de enfermagem, com vistas à eficácia da terapêutica. Palavras-chave: Palavras-chave: Palavras-chave: Palavras-chave: Palavras-chave: Cuidado de enfermagem; enfermagem neonatal; hipertensão pulmonar persistente; óxido nítrico. 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Objetiva enfocar os temas relacionados à sua administração e aos cuidados de enfermagem. Realizou-se a coleta de dados empíricos a partir das bases de dados MEDLINE, LILACS, BDENF, Biblioteca COCHRANE e vias não sistemáticas, no período de 1996 a 2003. As palavras-chave utilizadas foram: óxido nítrico, hipertensão pulmonar persistente, terapia intensiva neonatal, neonato, enfermagem neonatal e cuidados de enfermagem. Foram identificadas 190 publicações, 30 das quais se enquadravam nos objetivos da pesquisa. O estudo permitiu a organização do conhecimento produzido, possibilitando a apresentação dos dados em temas relacionados aos equipamentos de administração do óxido nítrico e às condutas ligadas à própria terapêutica, fornecendo subsídios teóricos para a sistematização da assistência de enfermagem, com vistas à eficácia da terapêutica. Palavras-chave: Palavras-chave: Palavras-chave: Palavras-chave: Palavras-chave: Cuidado de enfermagem; enfermagem neonatal; hipertensão pulmonar persistente; óxido nítrico. 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bilateral leg edema in a primary care setting, and to determine the ability of primary care providers to arrive at the correct diagnosis using the information available at the initial clinical encounter. PATIENTS... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24885600" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To identify the causes of bilateral leg edema in a primary care setting, and to determine the ability of primary care providers to arrive at the correct diagnosis using the information available at the initial clinical encounter. PATIENTS AND METHODS: Fifty-eight ambulatory adult patients with bilateral leg edema were enrolled at an inner city family practice during a 3-year period. Historical information, physical examination findings, and clinical impressions of primary care providers were compared with the results of laboratory evaluations consisting of echocardiograms, venous duplex ultrasound leg scans, serum albumin levels, and when appropriate, 24-hour urinalyses. RESULTS: Forty-five patients (78%) completed the study. The initial clinical impression was venous insufficiency in 32 (71%) patients and congestive heart failure in 8 (18%) patients. In</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24885600" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9d9297b0d590dc7e31d349acf448c096" rel="nofollow" data-download="{"attachment_id":45205532,"asset_id":24885600,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45205532/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="47791642" href="https://case.academia.edu/StephenZyzanski">Stephen Zyzanski</a><script data-card-contents-for-user="47791642" type="text/json">{"id":47791642,"first_name":"Stephen","last_name":"Zyzanski","domain_name":"case","page_name":"StephenZyzanski","display_name":"Stephen Zyzanski","profile_url":"https://case.academia.edu/StephenZyzanski?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24885600 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24885600"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24885600, container: ".js-paper-rank-work_24885600", }); 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$(".js-view-count[data-work-id=24885600]").text(description); $(".js-view-count-work_24885600").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24885600").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24885600"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="633" rel="nofollow" href="https://www.academia.edu/Documents/in/Primary_Care">Primary Care</a>, <script data-card-contents-for-ri="633" type="text/json">{"id":633,"name":"Primary Care","url":"https://www.academia.edu/Documents/in/Primary_Care?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2974" rel="nofollow" href="https://www.academia.edu/Documents/in/Primary_Health_Care">Primary Health Care</a>, <script data-card-contents-for-ri="2974" type="text/json">{"id":2974,"name":"Primary Health Care","url":"https://www.academia.edu/Documents/in/Primary_Health_Care?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="15639" rel="nofollow" href="https://www.academia.edu/Documents/in/Ultrasound">Ultrasound</a>, <script data-card-contents-for-ri="15639" type="text/json">{"id":15639,"name":"Ultrasound","url":"https://www.academia.edu/Documents/in/Ultrasound?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="25469" rel="nofollow" href="https://www.academia.edu/Documents/in/Family_Practice">Family Practice</a><script data-card-contents-for-ri="25469" type="text/json">{"id":25469,"name":"Family Practice","url":"https://www.academia.edu/Documents/in/Family_Practice?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24885600]'), work: {"id":24885600,"title":"Etiology and diagnosis of bilateral leg edema in primary care","created_at":"2016-04-29T11:15:40.059-07:00","url":"https://www.academia.edu/24885600/Etiology_and_diagnosis_of_bilateral_leg_edema_in_primary_care?f_ri=31958","dom_id":"work_24885600","summary":"To identify the causes of bilateral leg edema in a primary care setting, and to determine the ability of primary care providers to arrive at the correct diagnosis using the information available at the initial clinical encounter. PATIENTS AND METHODS: Fifty-eight ambulatory adult patients with bilateral leg edema were enrolled at an inner city family practice during a 3-year period. Historical information, physical examination findings, and clinical impressions of primary care providers were compared with the results of laboratory evaluations consisting of echocardiograms, venous duplex ultrasound leg scans, serum albumin levels, and when appropriate, 24-hour urinalyses. RESULTS: Forty-five patients (78%) completed the study. The initial clinical impression was venous insufficiency in 32 (71%) patients and congestive heart failure in 8 (18%) patients. In","downloadable_attachments":[{"id":45205532,"asset_id":24885600,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":47791642,"first_name":"Stephen","last_name":"Zyzanski","domain_name":"case","page_name":"StephenZyzanski","display_name":"Stephen Zyzanski","profile_url":"https://case.academia.edu/StephenZyzanski?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":633,"name":"Primary Care","url":"https://www.academia.edu/Documents/in/Primary_Care?f_ri=31958","nofollow":true},{"id":2974,"name":"Primary Health Care","url":"https://www.academia.edu/Documents/in/Primary_Health_Care?f_ri=31958","nofollow":true},{"id":15639,"name":"Ultrasound","url":"https://www.academia.edu/Documents/in/Ultrasound?f_ri=31958","nofollow":true},{"id":25469,"name":"Family Practice","url":"https://www.academia.edu/Documents/in/Family_Practice?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958"},{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=31958"},{"id":162159,"name":"Differential Diagnosis","url":"https://www.academia.edu/Documents/in/Differential_Diagnosis?f_ri=31958"},{"id":228832,"name":"Heart Disease","url":"https://www.academia.edu/Documents/in/Heart_Disease?f_ri=31958"},{"id":273520,"name":"Ohio","url":"https://www.academia.edu/Documents/in/Ohio?f_ri=31958"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=31958"},{"id":382481,"name":"Edema","url":"https://www.academia.edu/Documents/in/Edema?f_ri=31958"},{"id":516735,"name":"Physical examination","url":"https://www.academia.edu/Documents/in/Physical_examination?f_ri=31958"},{"id":570668,"name":"Urban Population","url":"https://www.academia.edu/Documents/in/Urban_Population?f_ri=31958"},{"id":704648,"name":"Clinical Competence","url":"https://www.academia.edu/Documents/in/Clinical_Competence?f_ri=31958"},{"id":881608,"name":"Bovine Serum Albumin","url":"https://www.academia.edu/Documents/in/Bovine_Serum_Albumin?f_ri=31958"},{"id":1863718,"name":"The American","url":"https://www.academia.edu/Documents/in/The_American?f_ri=31958"},{"id":2349258,"name":"Serum albumin","url":"https://www.academia.edu/Documents/in/Serum_albumin?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_1514408" data-work_id="1514408" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/1514408/Mutations_in_the_G6PC3_gene_cause_Dursun_syndrome">Mutations in the G6PC3 gene cause Dursun syndrome</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Dursun syndrome is a triad of familial primary pulmonary hypertension, leucopenia, and atrial septal defect. Here we demonstrate that mutations in G6PC3 cause Dursun syndrome. Mutations in G6PC3 are known to also cause severe congenital... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_1514408" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Dursun syndrome is a triad of familial primary pulmonary hypertension, leucopenia, and atrial septal defect. Here we demonstrate that mutations in G6PC3 cause Dursun syndrome. Mutations in G6PC3 are known to also cause severe congenital neutropenia type 4. Identification of the genetic basis of Dursun syndrome expands the pre-existing knowledge about the phenotypic effects of mutations in G6PC3. We propose that Dursun syndrome should now be considered as a subset of severe congenital neutropenia type 4 with pulmonary hypertension as an important clinical feature. © 2010 Wiley-Liss, Inc.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/1514408" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6403ae6c6cd67fcd8564e25ef4836b00" rel="nofollow" data-download="{"attachment_id":50944510,"asset_id":1514408,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50944510/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1547142" href="https://manchester.academia.edu/SiddharthBanka">Siddharth Banka</a><script data-card-contents-for-user="1547142" type="text/json">{"id":1547142,"first_name":"Siddharth","last_name":"Banka","domain_name":"manchester","page_name":"SiddharthBanka","display_name":"Siddharth Banka","profile_url":"https://manchester.academia.edu/SiddharthBanka?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_1514408 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="1514408"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 1514408, container: ".js-paper-rank-work_1514408", }); 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$(".js-view-count[data-work-id=1514408]").text(description); $(".js-view-count-work_1514408").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_1514408").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="1514408"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="74780" rel="nofollow" href="https://www.academia.edu/Documents/in/Mutation">Mutation</a>, <script data-card-contents-for-ri="74780" type="text/json">{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="84760" rel="nofollow" href="https://www.academia.edu/Documents/in/Mice">Mice</a><script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=1514408]'), work: {"id":1514408,"title":"Mutations in the G6PC3 gene cause Dursun syndrome","created_at":"2012-04-18T07:35:09.933-07:00","url":"https://www.academia.edu/1514408/Mutations_in_the_G6PC3_gene_cause_Dursun_syndrome?f_ri=31958","dom_id":"work_1514408","summary":"Dursun syndrome is a triad of familial primary pulmonary hypertension, leucopenia, and atrial septal defect. Here we demonstrate that mutations in G6PC3 cause Dursun syndrome. Mutations in G6PC3 are known to also cause severe congenital neutropenia type 4. Identification of the genetic basis of Dursun syndrome expands the pre-existing knowledge about the phenotypic effects of mutations in G6PC3. We propose that Dursun syndrome should now be considered as a subset of severe congenital neutropenia type 4 with pulmonary hypertension as an important clinical feature. © 2010 Wiley-Liss, Inc.","downloadable_attachments":[{"id":50944510,"asset_id":1514408,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":1547142,"first_name":"Siddharth","last_name":"Banka","domain_name":"manchester","page_name":"SiddharthBanka","display_name":"Siddharth Banka","profile_url":"https://manchester.academia.edu/SiddharthBanka?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=31958","nofollow":true},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=31958","nofollow":true},{"id":181936,"name":"Gene","url":"https://www.academia.edu/Documents/in/Gene?f_ri=31958"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle?f_ri=31958"},{"id":316015,"name":"Gen","url":"https://www.academia.edu/Documents/in/Gen?f_ri=31958"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=31958"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=31958"},{"id":1225171,"name":"Syndrome","url":"https://www.academia.edu/Documents/in/Syndrome?f_ri=31958"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data?f_ri=31958"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13547908 coauthored" data-work_id="13547908" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13547908/Patent_ductus_arteriosus_stenting_for_palliation_of_severe_pulmonary_arterial_hypertension_in_childhood">Patent ductus arteriosus stenting for palliation of severe pulmonary arterial hypertension in childhood</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A 4.5-year-old child with severe idiopathic pulmonary arterial hypertension underwent right-heart catheterisation, showing suprasystemic pulmonary pressure and a tiny patent ductus arteriosus with trivial rightto-left shunting. The ductus... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13547908" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A 4.5-year-old child with severe idiopathic pulmonary arterial hypertension underwent right-heart catheterisation, showing suprasystemic pulmonary pressure and a tiny patent ductus arteriosus with trivial rightto-left shunting. The ductus arteriosus was successfully stented with a bare metal stent. At 1-year follow-up, a remarkable improvement was observed in clinical status, functional capacity, and serology. Echocardiography confirmed a favourable cardiac remodelling.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13547908" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4ce5e406d1acf63e68cad0e13f41a964" rel="nofollow" data-download="{"attachment_id":45223391,"asset_id":13547908,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45223391/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32737420" href="https://unina2.academia.edu/MariaRusso">Maria Russo</a><script data-card-contents-for-user="32737420" type="text/json">{"id":32737420,"first_name":"Maria","last_name":"Russo","domain_name":"unina2","page_name":"MariaRusso","display_name":"Maria Russo","profile_url":"https://unina2.academia.edu/MariaRusso?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-13547908">+1</span><div class="hidden js-additional-users-13547908"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/MicheleDAlto">Michele D'Alto</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-13547908'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-13547908').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_13547908 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13547908"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13547908, container: ".js-paper-rank-work_13547908", }); });</script></li><li class="js-percentile-work_13547908 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13547908; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13547908"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13547908 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13547908"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13547908; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13547908]").text(description); $(".js-view-count-work_13547908").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13547908").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13547908"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="4482" rel="nofollow" href="https://www.academia.edu/Documents/in/Palliative_Care">Palliative Care</a>, <script data-card-contents-for-ri="4482" type="text/json">{"id":4482,"name":"Palliative Care","url":"https://www.academia.edu/Documents/in/Palliative_Care?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="27521" rel="nofollow" href="https://www.academia.edu/Documents/in/Stents">Stents</a>, <script data-card-contents-for-ri="27521" type="text/json">{"id":27521,"name":"Stents","url":"https://www.academia.edu/Documents/in/Stents?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="323537" rel="nofollow" href="https://www.academia.edu/Documents/in/Haemodynamics">Haemodynamics</a><script data-card-contents-for-ri="323537" type="text/json">{"id":323537,"name":"Haemodynamics","url":"https://www.academia.edu/Documents/in/Haemodynamics?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13547908]'), work: {"id":13547908,"title":"Patent ductus arteriosus stenting for palliation of severe pulmonary arterial hypertension in childhood","created_at":"2015-07-02T08:49:27.444-07:00","url":"https://www.academia.edu/13547908/Patent_ductus_arteriosus_stenting_for_palliation_of_severe_pulmonary_arterial_hypertension_in_childhood?f_ri=31958","dom_id":"work_13547908","summary":"A 4.5-year-old child with severe idiopathic pulmonary arterial hypertension underwent right-heart catheterisation, showing suprasystemic pulmonary pressure and a tiny patent ductus arteriosus with trivial rightto-left shunting. The ductus arteriosus was successfully stented with a bare metal stent. At 1-year follow-up, a remarkable improvement was observed in clinical status, functional capacity, and serology. Echocardiography confirmed a favourable cardiac remodelling.","downloadable_attachments":[{"id":45223391,"asset_id":13547908,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32737420,"first_name":"Maria","last_name":"Russo","domain_name":"unina2","page_name":"MariaRusso","display_name":"Maria Russo","profile_url":"https://unina2.academia.edu/MariaRusso?f_ri=31958","photo":"/images/s65_no_pic.png"},{"id":35945154,"first_name":"Michele","last_name":"D'Alto","domain_name":"independent","page_name":"MicheleDAlto","display_name":"Michele D'Alto","profile_url":"https://independent.academia.edu/MicheleDAlto?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4482,"name":"Palliative Care","url":"https://www.academia.edu/Documents/in/Palliative_Care?f_ri=31958","nofollow":true},{"id":27521,"name":"Stents","url":"https://www.academia.edu/Documents/in/Stents?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":323537,"name":"Haemodynamics","url":"https://www.academia.edu/Documents/in/Haemodynamics?f_ri=31958","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_29004892" data-work_id="29004892" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/29004892/Risk_of_persistent_pulmonary_hypertension_of_the_neonate_in_twin_to_twin_transfusion_syndrome">Risk of persistent pulmonary hypertension of the neonate in twin-to-twin transfusion syndrome</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Chronic twin-to-twin transfusion syndrome (TTTS) is a complication of monochorionic twin gestations and is associated with high perinatal mortality and increased neurological, cardiovascular and renal morbidity. To report the risk of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_29004892" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Chronic twin-to-twin transfusion syndrome (TTTS) is a complication of monochorionic twin gestations and is associated with high perinatal mortality and increased neurological, cardiovascular and renal morbidity. To report the risk of severe persistent pulmonary hypertension of the newborn (PPHN) in TTTS and discuss the possible association between severe PPHN and TTTS. All cases of monochorionic twins with severe PPHN at birth admitted to our nursery between June 2002 and July 2006 were reviewed retrospectively. We compared the incidence of severe PPHN in monochorionic twins with and without TTTS. Severe PPHN was diagnosed according to clinical and ultrasound criteria when an infant with a structurally normal heart had (1) severe hypoxemia and (2) evidence of a right-to-left shunt on persistent ductus arteriosus or foramen ovale, requiring treatment with inhaled nitric oxide (iNO). In a consecutive series of 73 twin pregnancies with TTTS, 4 of the 135 live-born twins (3%) were affec...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/29004892" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ca3d2db3fa9c5ad1912f39ad09316a69" rel="nofollow" data-download="{"attachment_id":49453463,"asset_id":29004892,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49453463/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35808696" href="https://independent.academia.edu/NicoBlom">Nico Blom</a><script data-card-contents-for-user="35808696" type="text/json">{"id":35808696,"first_name":"Nico","last_name":"Blom","domain_name":"independent","page_name":"NicoBlom","display_name":"Nico Blom","profile_url":"https://independent.academia.edu/NicoBlom?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_29004892 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="29004892"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 29004892, container: ".js-paper-rank-work_29004892", }); 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To report the risk of severe persistent pulmonary hypertension of the newborn (PPHN) in TTTS and discuss the possible association between severe PPHN and TTTS. All cases of monochorionic twins with severe PPHN at birth admitted to our nursery between June 2002 and July 2006 were reviewed retrospectively. We compared the incidence of severe PPHN in monochorionic twins with and without TTTS. Severe PPHN was diagnosed according to clinical and ultrasound criteria when an infant with a structurally normal heart had (1) severe hypoxemia and (2) evidence of a right-to-left shunt on persistent ductus arteriosus or foramen ovale, requiring treatment with inhaled nitric oxide (iNO). In a consecutive series of 73 twin pregnancies with TTTS, 4 of the 135 live-born twins (3%) were affec...","downloadable_attachments":[{"id":49453463,"asset_id":29004892,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35808696,"first_name":"Nico","last_name":"Blom","domain_name":"independent","page_name":"NicoBlom","display_name":"Nico Blom","profile_url":"https://independent.academia.edu/NicoBlom?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":15639,"name":"Ultrasound","url":"https://www.academia.edu/Documents/in/Ultrasound?f_ri=31958","nofollow":true},{"id":24853,"name":"Neonatology","url":"https://www.academia.edu/Documents/in/Neonatology?f_ri=31958","nofollow":true},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=31958"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=31958"},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=31958"},{"id":157892,"name":"Netherlands","url":"https://www.academia.edu/Documents/in/Netherlands?f_ri=31958"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=31958"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=31958"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=31958"},{"id":380018,"name":"Donor","url":"https://www.academia.edu/Documents/in/Donor?f_ri=31958"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=31958"},{"id":671891,"name":"Perinatal mortality","url":"https://www.academia.edu/Documents/in/Perinatal_mortality?f_ri=31958"},{"id":797418,"name":"Gestational Age","url":"https://www.academia.edu/Documents/in/Gestational_Age?f_ri=31958"},{"id":1147308,"name":"Ductus Arteriosus","url":"https://www.academia.edu/Documents/in/Ductus_Arteriosus?f_ri=31958"},{"id":1321043,"name":"Twin Pregnancy","url":"https://www.academia.edu/Documents/in/Twin_Pregnancy?f_ri=31958"},{"id":2416700,"name":"Inhaled Nitric Oxide","url":"https://www.academia.edu/Documents/in/Inhaled_Nitric_Oxide?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_43806704" data-work_id="43806704" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/43806704/Circulating_Serotonin_Catecholamines_and_Central_Nervous_System_Circuitry_Related_to_Some_Cardiorespiratory_Vascular_and_Hematological_Disorders">Circulating Serotonin, Catecholamines, and Central Nervous System Circuitry Related to Some Cardiorespiratory, Vascular, and Hematological Disorders</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">This review presents results that show that assessment of circulating neurotransmitters is the most effective and, indeed imperative, way to attain a scientific approach to the autonomic nervous system (ANS). The resulting ANS profile... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_43806704" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This review presents results that show that assessment of circulating neurotransmitters is the most effective and, indeed imperative, way to attain a scientific approach to the autonomic nervous system (ANS). The resulting ANS profile makes it possible to prescribe neuropharmacologic therapies to correct central nervous system circuitry disorders responsible for the abnormalities registered at the peripheral ANS level. Some examples of disastrous therapeutic trials based on poor knowledge of neuropharmacology and the ANS in general are provided. In addition, data regarding the protagonist role exerted by circulating plasma serotonin in pulmonary bronchoconstriction, pulmonary vasoconstriction, and platelet serotonin in both cardiovascular and hematological disorders are given. All of these disorders were dramatically improved by the administration of neuropharmacologic agents that affected both platelet and neuronal serotonin uptake.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/43806704" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1ecc3a6728d6f294328a7e4bc212e8c1" rel="nofollow" data-download="{"attachment_id":64124500,"asset_id":43806704,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/64124500/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="66806619" href="https://bcm.academia.edu/DrAlexLechin">Dr. Alex Lechin</a><script data-card-contents-for-user="66806619" type="text/json">{"id":66806619,"first_name":"Dr. Alex","last_name":"Lechin","domain_name":"bcm","page_name":"DrAlexLechin","display_name":"Dr. Alex Lechin","profile_url":"https://bcm.academia.edu/DrAlexLechin?f_ri=31958","photo":"https://0.academia-photos.com/66806619/17487651/17563291/s65_alex.lechin.jpg"}</script></span></span></li><li class="js-paper-rank-work_43806704 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="43806704"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 43806704, container: ".js-paper-rank-work_43806704", }); 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$(".js-view-count[data-work-id=43806704]").text(description); $(".js-view-count-work_43806704").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_43806704").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="43806704"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9968" rel="nofollow" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="51565" rel="nofollow" href="https://www.academia.edu/Documents/in/Serotonin">Serotonin</a>, <script data-card-contents-for-ri="51565" type="text/json">{"id":51565,"name":"Serotonin","url":"https://www.academia.edu/Documents/in/Serotonin?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="51566" rel="nofollow" href="https://www.academia.edu/Documents/in/Dopamine">Dopamine</a><script data-card-contents-for-ri="51566" type="text/json">{"id":51566,"name":"Dopamine","url":"https://www.academia.edu/Documents/in/Dopamine?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=43806704]'), work: {"id":43806704,"title":"Circulating Serotonin, Catecholamines, and Central Nervous System Circuitry Related to Some Cardiorespiratory, Vascular, and Hematological Disorders","created_at":"2020-08-07T21:33:17.531-07:00","url":"https://www.academia.edu/43806704/Circulating_Serotonin_Catecholamines_and_Central_Nervous_System_Circuitry_Related_to_Some_Cardiorespiratory_Vascular_and_Hematological_Disorders?f_ri=31958","dom_id":"work_43806704","summary":"This review presents results that show that assessment of circulating neurotransmitters is the most effective and, indeed imperative, way to attain a scientific approach to the autonomic nervous system (ANS). The resulting ANS profile makes it possible to prescribe neuropharmacologic therapies to correct central nervous system circuitry disorders responsible for the abnormalities registered at the peripheral ANS level. Some examples of disastrous therapeutic trials based on poor knowledge of neuropharmacology and the ANS in general are provided. In addition, data regarding the protagonist role exerted by circulating plasma serotonin in pulmonary bronchoconstriction, pulmonary vasoconstriction, and platelet serotonin in both cardiovascular and hematological disorders are given. All of these disorders were dramatically improved by the administration of neuropharmacologic agents that affected both platelet and neuronal serotonin uptake.","downloadable_attachments":[{"id":64124500,"asset_id":43806704,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":66806619,"first_name":"Dr. Alex","last_name":"Lechin","domain_name":"bcm","page_name":"DrAlexLechin","display_name":"Dr. Alex Lechin","profile_url":"https://bcm.academia.edu/DrAlexLechin?f_ri=31958","photo":"https://0.academia-photos.com/66806619/17487651/17563291/s65_alex.lechin.jpg"}],"research_interests":[{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":51565,"name":"Serotonin","url":"https://www.academia.edu/Documents/in/Serotonin?f_ri=31958","nofollow":true},{"id":51566,"name":"Dopamine","url":"https://www.academia.edu/Documents/in/Dopamine?f_ri=31958","nofollow":true},{"id":51568,"name":"Noradrenaline","url":"https://www.academia.edu/Documents/in/Noradrenaline?f_ri=31958"},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension?f_ri=31958"},{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=31958"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System?f_ri=31958"},{"id":564886,"name":"Adrenaline","url":"https://www.academia.edu/Documents/in/Adrenaline?f_ri=31958"},{"id":2003956,"name":"Autonomic Nervous System Dysfunction","url":"https://www.academia.edu/Documents/in/Autonomic_Nervous_System_Dysfunction?f_ri=31958"},{"id":2584186,"name":"polycythemia vera","url":"https://www.academia.edu/Documents/in/polycythemia_vera?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_4590692" data-work_id="4590692" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/4590692/PULMONARY_HYPERTENSION_AND_ANESTHESIA">PULMONARY HYPERTENSION AND ANESTHESIA</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4590692" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="599d9e4844e79267568b36f4beeab0c1" rel="nofollow" data-download="{"attachment_id":31958203,"asset_id":4590692,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/31958203/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5766099" href="https://umontreal.academia.edu/ElieChidiac">Elie Chidiac</a><script data-card-contents-for-user="5766099" type="text/json">{"id":5766099,"first_name":"Elie","last_name":"Chidiac","domain_name":"umontreal","page_name":"ElieChidiac","display_name":"Elie Chidiac","profile_url":"https://umontreal.academia.edu/ElieChidiac?f_ri=31958","photo":"https://0.academia-photos.com/5766099/2487524/2889357/s65_elie.chidiac.jpg"}</script></span></span></li><li class="js-paper-rank-work_4590692 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="4590692"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 4590692, container: ".js-paper-rank-work_4590692", }); });</script></li><li class="js-percentile-work_4590692 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4590692; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_4590692"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_4590692 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="4590692"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4590692; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4590692]").text(description); $(".js-view-count-work_4590692").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_4590692").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="4590692"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="46824" rel="nofollow" href="https://www.academia.edu/Documents/in/Echocardiography">Echocardiography</a>, <script data-card-contents-for-ri="46824" type="text/json">{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="254060" rel="nofollow" href="https://www.academia.edu/Documents/in/General_Anesthesia">General Anesthesia</a>, <script data-card-contents-for-ri="254060" type="text/json">{"id":254060,"name":"General Anesthesia","url":"https://www.academia.edu/Documents/in/General_Anesthesia?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="516735" rel="nofollow" href="https://www.academia.edu/Documents/in/Physical_examination">Physical examination</a><script data-card-contents-for-ri="516735" type="text/json">{"id":516735,"name":"Physical examination","url":"https://www.academia.edu/Documents/in/Physical_examination?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=4590692]'), work: {"id":4590692,"title":"PULMONARY HYPERTENSION AND ANESTHESIA","created_at":"2013-09-25T23:10:42.384-07:00","url":"https://www.academia.edu/4590692/PULMONARY_HYPERTENSION_AND_ANESTHESIA?f_ri=31958","dom_id":"work_4590692","summary":null,"downloadable_attachments":[{"id":31958203,"asset_id":4590692,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5766099,"first_name":"Elie","last_name":"Chidiac","domain_name":"umontreal","page_name":"ElieChidiac","display_name":"Elie Chidiac","profile_url":"https://umontreal.academia.edu/ElieChidiac?f_ri=31958","photo":"https://0.academia-photos.com/5766099/2487524/2889357/s65_elie.chidiac.jpg"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=31958","nofollow":true},{"id":254060,"name":"General Anesthesia","url":"https://www.academia.edu/Documents/in/General_Anesthesia?f_ri=31958","nofollow":true},{"id":516735,"name":"Physical examination","url":"https://www.academia.edu/Documents/in/Physical_examination?f_ri=31958","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_4747194" data-work_id="4747194" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/4747194/Pulmonary_vascular_and_right_ventricular_dysfunction_in_adult_critical_care_current_and_emerging_options_for_management_a_systematic_literature_review">Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Introduction: Pulmonary vascular dysfunction, pulmonary hypertension (PH), and resulting right ventricular (RV) failure occur in many critical illnesses and may be associated with a worse prognosis. PH and RV failure may be difficult to... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_4747194" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Introduction: Pulmonary vascular dysfunction, pulmonary hypertension (PH), and resulting right ventricular (RV) failure occur in many critical illnesses and may be associated with a worse prognosis. PH and RV failure may be difficult to manage: principles include maintenance of appropriate RV preload, augmentation of RV function, and reduction of RV afterload by lowering pulmonary vascular resistance (PVR). We therefore provide a detailed update on the management of PH and RV failure in adult critical care. Methods: A systematic review was performed, based on a search of the literature from 1980 to 2010, by using prespecified search terms. Relevant studies were subjected to analysis based on the GRADE method.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4747194" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8056c8222ede8d0ac05512e12ae9a139" rel="nofollow" data-download="{"attachment_id":32060393,"asset_id":4747194,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/32060393/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="6081228" href="https://independent.academia.edu/lauraprice3">laura price</a><script data-card-contents-for-user="6081228" type="text/json">{"id":6081228,"first_name":"laura","last_name":"price","domain_name":"independent","page_name":"lauraprice3","display_name":"laura price","profile_url":"https://independent.academia.edu/lauraprice3?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_4747194 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="4747194"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 4747194, container: ".js-paper-rank-work_4747194", }); });</script></li><li class="js-percentile-work_4747194 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4747194; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_4747194"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_4747194 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="4747194"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4747194; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4747194]").text(description); $(".js-view-count-work_4747194").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_4747194").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="4747194"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="32538" rel="nofollow" href="https://www.academia.edu/Documents/in/Critical_Care">Critical Care</a>, <script data-card-contents-for-ri="32538" type="text/json">{"id":32538,"name":"Critical Care","url":"https://www.academia.edu/Documents/in/Critical_Care?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="39851" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiac_Surgery">Cardiac Surgery</a>, <script data-card-contents-for-ri="39851" type="text/json">{"id":39851,"name":"Cardiac Surgery","url":"https://www.academia.edu/Documents/in/Cardiac_Surgery?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="66683" rel="nofollow" href="https://www.academia.edu/Documents/in/Systematic_Literature_Review">Systematic Literature Review</a><script data-card-contents-for-ri="66683" type="text/json">{"id":66683,"name":"Systematic Literature Review","url":"https://www.academia.edu/Documents/in/Systematic_Literature_Review?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=4747194]'), work: {"id":4747194,"title":"Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review","created_at":"2013-10-11T03:56:54.835-07:00","url":"https://www.academia.edu/4747194/Pulmonary_vascular_and_right_ventricular_dysfunction_in_adult_critical_care_current_and_emerging_options_for_management_a_systematic_literature_review?f_ri=31958","dom_id":"work_4747194","summary":"Introduction: Pulmonary vascular dysfunction, pulmonary hypertension (PH), and resulting right ventricular (RV) failure occur in many critical illnesses and may be associated with a worse prognosis. PH and RV failure may be difficult to manage: principles include maintenance of appropriate RV preload, augmentation of RV function, and reduction of RV afterload by lowering pulmonary vascular resistance (PVR). We therefore provide a detailed update on the management of PH and RV failure in adult critical care. Methods: A systematic review was performed, based on a search of the literature from 1980 to 2010, by using prespecified search terms. Relevant studies were subjected to analysis based on the GRADE method.","downloadable_attachments":[{"id":32060393,"asset_id":4747194,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":6081228,"first_name":"laura","last_name":"price","domain_name":"independent","page_name":"lauraprice3","display_name":"laura price","profile_url":"https://independent.academia.edu/lauraprice3?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":32538,"name":"Critical Care","url":"https://www.academia.edu/Documents/in/Critical_Care?f_ri=31958","nofollow":true},{"id":39851,"name":"Cardiac Surgery","url":"https://www.academia.edu/Documents/in/Cardiac_Surgery?f_ri=31958","nofollow":true},{"id":66683,"name":"Systematic Literature Review","url":"https://www.academia.edu/Documents/in/Systematic_Literature_Review?f_ri=31958","nofollow":true},{"id":72821,"name":"Low Dose","url":"https://www.academia.edu/Documents/in/Low_Dose?f_ri=31958"},{"id":94234,"name":"INTENSIVE CARE","url":"https://www.academia.edu/Documents/in/INTENSIVE_CARE?f_ri=31958"},{"id":221411,"name":"Systematic review","url":"https://www.academia.edu/Documents/in/Systematic_review?f_ri=31958"},{"id":274856,"name":"Phosphodiesterase Inhibitors","url":"https://www.academia.edu/Documents/in/Phosphodiesterase_Inhibitors?f_ri=31958"},{"id":546356,"name":"Clinical Study","url":"https://www.academia.edu/Documents/in/Clinical_Study?f_ri=31958"},{"id":698785,"name":"Side Effect","url":"https://www.academia.edu/Documents/in/Side_Effect?f_ri=31958"},{"id":906958,"name":"Disease Management","url":"https://www.academia.edu/Documents/in/Disease_Management?f_ri=31958"},{"id":1969879,"name":"Vascular Resistance","url":"https://www.academia.edu/Documents/in/Vascular_Resistance?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5642943" data-work_id="5642943" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5642943/Formulation_of_Pulsatile_Delivery_of_Ramipril_A_ChronoPharmaceutical_Approach_for_the_Treatment_of_Hypertension">Formulation of Pulsatile Delivery of Ramipril: A ChronoPharmaceutical Approach for the Treatment of Hypertension</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of present study was to formulate and evaluate oral multiparticulate pulsatile release of ramipril based on chronophamaceutical approach for the treatment of hypertension. In the present study the immediate release core mini... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5642943" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of present study was to formulate and evaluate oral multiparticulate pulsatile release of ramipril based on chronophamaceutical approach for the treatment of hypertension. In the present study the immediate release core mini tablets were prepared by direct compression by using various proportions of different superdisintegrants. The optimized core tablets were then coated with pH sensitive polymers like Eudragit -S100 and Eudragit-L100. To achieve the desired dissolution profile, various parameters like coating duration and coat thickness studied. The coated tablets were evaluated for hardness, thickness, friability, weight variation, drug content, and disintegration time and in-vitro drug release. In-vitro drug release was found to be 98 % from coated tablets in 20 min after 5 hrs lag time. FT-IR spectra revealed that there is no chemical incompatibility between the drug and other excipients. Scanning electron micrograph of optimized tablet shown that the thickness level in the coating. The results concluded the programmable pulsatile release has been achieved from coated tablets after a lag time of 5 hrs, which is consistent with the demands of the chronotherapeutic drug delivery and increasing bioavailability. Prasad et al___________________________________________________________________ BBB[1][1][2013]005-017</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5642943" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0111a20016e5f40f5e187ae81cf8c4b5" rel="nofollow" data-download="{"attachment_id":32707099,"asset_id":5642943,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/32707099/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="7856206" href="https://independent.academia.edu/EditorBBB">British Biomedical Bulletin</a><script data-card-contents-for-user="7856206" type="text/json">{"id":7856206,"first_name":"British Biomedical","last_name":"Bulletin","domain_name":"independent","page_name":"EditorBBB","display_name":"British Biomedical Bulletin","profile_url":"https://independent.academia.edu/EditorBBB?f_ri=31958","photo":"https://0.academia-photos.com/7856206/5915532/6716757/s65_british_biomedical.bulletin.jpg"}</script></span></span></li><li class="js-paper-rank-work_5642943 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5642943"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5642943, container: ".js-paper-rank-work_5642943", }); 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Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=31958","nofollow":true},{"id":27521,"name":"Stents","url":"https://www.academia.edu/Documents/in/Stents?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=31958"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_29116187" data-work_id="29116187" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/29116187/Risk_factors_and_pathophysiology_of_chronic_obstructive_pulmonary_disease_COPD_">Risk factors and pathophysiology of chronic obstructive pulmonary disease (COPD)</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/29116187" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f0c2dac1d8ab6ba4c97b807b2f3ff6c8" rel="nofollow" data-download="{"attachment_id":49565507,"asset_id":29116187,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button 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Kodgule","profile_url":"https://crfindia.academia.edu/DrRRKodgule?f_ri=31958","photo":"https://0.academia-photos.com/54509175/113092668/102360980/s65_rahul.kodgule.jpeg"}</script></span></span></li><li class="js-paper-rank-work_29116187 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="29116187"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 29116187, container: ".js-paper-rank-work_29116187", }); });</script></li><li class="js-percentile-work_29116187 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 29116187; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = 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Pollution","url":"https://www.academia.edu/Documents/in/Environmental_Pollution?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="28973" rel="nofollow" href="https://www.academia.edu/Documents/in/Comorbidity">Comorbidity</a>, <script data-card-contents-for-ri="28973" type="text/json">{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a><script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=29116187]'), work: {"id":29116187,"title":"Risk factors and pathophysiology of chronic obstructive pulmonary disease (COPD)","created_at":"2016-10-13T00:13:30.770-07:00","url":"https://www.academia.edu/29116187/Risk_factors_and_pathophysiology_of_chronic_obstructive_pulmonary_disease_COPD_?f_ri=31958","dom_id":"work_29116187","summary":null,"downloadable_attachments":[{"id":49565507,"asset_id":29116187,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":54509175,"first_name":"Rahul","last_name":"Kodgule","domain_name":"crfindia","page_name":"DrRRKodgule","display_name":"Rahul Kodgule","profile_url":"https://crfindia.academia.edu/DrRRKodgule?f_ri=31958","photo":"https://0.academia-photos.com/54509175/113092668/102360980/s65_rahul.kodgule.jpeg"}],"research_interests":[{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=31958","nofollow":true},{"id":25445,"name":"Environmental Pollution","url":"https://www.academia.edu/Documents/in/Environmental_Pollution?f_ri=31958","nofollow":true},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=31958"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung?f_ri=31958"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=31958"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=31958"},{"id":556576,"name":"Chronic obstructive pulmonary disease","url":"https://www.academia.edu/Documents/in/Chronic_obstructive_pulmonary_disease?f_ri=31958"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=31958"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=31958"},{"id":2345130,"name":"Socioeconomic Factors","url":"https://www.academia.edu/Documents/in/Socioeconomic_Factors?f_ri=31958"},{"id":2463800,"name":"Severity of Illness Index","url":"https://www.academia.edu/Documents/in/Severity_of_Illness_Index?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_23523142" data-work_id="23523142" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/23523142/Teste_de_vasorreatividade_pulmonar">Teste de vasorreatividade pulmonar</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">pulmonar, cardiopatias, vasculite pulmonar, colagenoses ou tromboembolismo pulmonar.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23523142" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ad0c179c2409c91eb276d9d1c3b04fba" rel="nofollow" data-download="{"attachment_id":43958635,"asset_id":23523142,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43958635/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="45544673" href="https://independent.academia.edu/MarcoMoura6">Marco Moura</a><script data-card-contents-for-user="45544673" type="text/json">{"id":45544673,"first_name":"Marco","last_name":"Moura","domain_name":"independent","page_name":"MarcoMoura6","display_name":"Marco Moura","profile_url":"https://independent.academia.edu/MarcoMoura6?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_23523142 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23523142"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23523142, container: ".js-paper-rank-work_23523142", }); });</script></li><li class="js-percentile-work_23523142 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 23523142; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_23523142"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_23523142 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="23523142"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 23523142; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=23523142]").text(description); $(".js-view-count-work_23523142").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_23523142").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="23523142"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="71342" rel="nofollow" href="https://www.academia.edu/Documents/in/Portal_hypertension">Portal hypertension</a>, <script data-card-contents-for-ri="71342" type="text/json">{"id":71342,"name":"Portal hypertension","url":"https://www.academia.edu/Documents/in/Portal_hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="93922" rel="nofollow" href="https://www.academia.edu/Documents/in/Nitric_oxide">Nitric oxide</a>, <script data-card-contents-for-ri="93922" type="text/json">{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="228832" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Disease">Heart Disease</a><script data-card-contents-for-ri="228832" type="text/json">{"id":228832,"name":"Heart Disease","url":"https://www.academia.edu/Documents/in/Heart_Disease?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23523142]'), work: {"id":23523142,"title":"Teste de vasorreatividade pulmonar","created_at":"2016-03-21T11:28:01.557-07:00","url":"https://www.academia.edu/23523142/Teste_de_vasorreatividade_pulmonar?f_ri=31958","dom_id":"work_23523142","summary":"pulmonar, cardiopatias, vasculite pulmonar, colagenoses ou tromboembolismo pulmonar.","downloadable_attachments":[{"id":43958635,"asset_id":23523142,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":45544673,"first_name":"Marco","last_name":"Moura","domain_name":"independent","page_name":"MarcoMoura6","display_name":"Marco Moura","profile_url":"https://independent.academia.edu/MarcoMoura6?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":71342,"name":"Portal hypertension","url":"https://www.academia.edu/Documents/in/Portal_hypertension?f_ri=31958","nofollow":true},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=31958","nofollow":true},{"id":228832,"name":"Heart Disease","url":"https://www.academia.edu/Documents/in/Heart_Disease?f_ri=31958","nofollow":true},{"id":350855,"name":"Peripheral Vascular Disease","url":"https://www.academia.edu/Documents/in/Peripheral_Vascular_Disease?f_ri=31958"},{"id":735030,"name":"Congenital Heart Disease","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Disease?f_ri=31958"},{"id":1698070,"name":"Heart Surgery","url":"https://www.academia.edu/Documents/in/Heart_Surgery?f_ri=31958"},{"id":2416700,"name":"Inhaled Nitric Oxide","url":"https://www.academia.edu/Documents/in/Inhaled_Nitric_Oxide?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_33904014" data-work_id="33904014" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/33904014/BMC_Pregnancy_and_Childbirth">BMC Pregnancy and Childbirth</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cyclic nucleotide phosphodiesterases (PDE) are the enzymes catalyzing the hydrolysis and inactivation of the second messengers, cAMP and cGMP. Eleven PDE families are described to date, and selective inhibitors of some PDEs families are... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_33904014" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cyclic nucleotide phosphodiesterases (PDE) are the enzymes catalyzing the hydrolysis and inactivation of the second messengers, cAMP and cGMP. Eleven PDE families are described to date, and selective inhibitors of some PDEs families are currently used in clinic for treating cardiovascular disorders, erectile dysfunction, and pulmonary hypertension. Isoforms of the PDE4 family are involved in smooth muscle contraction and inflammation. PDE4 selective inhibitors are currently in clinical trials for the treatment of diseases related to inflammatory disorders. Because of their myorelaxant properties, we first examined their expression in human myometrium and uncover an increased expression of one specific isoform, PDE4B2, in the near-term myometrium as compared to myometrium in the nonpregnant state. Using human myometrial cells in culture, we demonstrated that PDE4B2 can be induced by its own substrate, under the control of one of the major utero-contractile agonists, PGE2, itself upre...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/33904014" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5a4d7b20ed15bd50041b29d46dfe8102" rel="nofollow" data-download="{"attachment_id":53875964,"asset_id":33904014,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/53875964/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="27482149" href="https://independent.academia.edu/ToityDeave">Toity Deave</a><script data-card-contents-for-user="27482149" type="text/json">{"id":27482149,"first_name":"Toity","last_name":"Deave","domain_name":"independent","page_name":"ToityDeave","display_name":"Toity Deave","profile_url":"https://independent.academia.edu/ToityDeave?f_ri=31958","photo":"https://0.academia-photos.com/27482149/18521187/18486656/s65_toity.deave.jpg"}</script></span></span></li><li class="js-paper-rank-work_33904014 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="33904014"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 33904014, container: ".js-paper-rank-work_33904014", }); });</script></li><li class="js-percentile-work_33904014 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 33904014; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_33904014"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_33904014 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="33904014"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33904014; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=33904014]").text(description); $(".js-view-count-work_33904014").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_33904014").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="33904014"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="588" rel="nofollow" href="https://www.academia.edu/Documents/in/Nursing">Nursing</a>, <script data-card-contents-for-ri="588" type="text/json">{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4531" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Trial">Clinical Trial</a>, <script data-card-contents-for-ri="4531" type="text/json">{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37819" rel="nofollow" href="https://www.academia.edu/Documents/in/Erectile_dysfunction">Erectile dysfunction</a><script data-card-contents-for-ri="37819" type="text/json">{"id":37819,"name":"Erectile dysfunction","url":"https://www.academia.edu/Documents/in/Erectile_dysfunction?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=33904014]'), work: {"id":33904014,"title":"BMC Pregnancy and Childbirth","created_at":"2017-07-17T00:40:28.485-07:00","url":"https://www.academia.edu/33904014/BMC_Pregnancy_and_Childbirth?f_ri=31958","dom_id":"work_33904014","summary":"Cyclic nucleotide phosphodiesterases (PDE) are the enzymes catalyzing the hydrolysis and inactivation of the second messengers, cAMP and cGMP. Eleven PDE families are described to date, and selective inhibitors of some PDEs families are currently used in clinic for treating cardiovascular disorders, erectile dysfunction, and pulmonary hypertension. Isoforms of the PDE4 family are involved in smooth muscle contraction and inflammation. PDE4 selective inhibitors are currently in clinical trials for the treatment of diseases related to inflammatory disorders. Because of their myorelaxant properties, we first examined their expression in human myometrium and uncover an increased expression of one specific isoform, PDE4B2, in the near-term myometrium as compared to myometrium in the nonpregnant state. Using human myometrial cells in culture, we demonstrated that PDE4B2 can be induced by its own substrate, under the control of one of the major utero-contractile agonists, PGE2, itself upre...","downloadable_attachments":[{"id":53875964,"asset_id":33904014,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":27482149,"first_name":"Toity","last_name":"Deave","domain_name":"independent","page_name":"ToityDeave","display_name":"Toity Deave","profile_url":"https://independent.academia.edu/ToityDeave?f_ri=31958","photo":"https://0.academia-photos.com/27482149/18521187/18486656/s65_toity.deave.jpg"}],"research_interests":[{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=31958","nofollow":true},{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":37819,"name":"Erectile dysfunction","url":"https://www.academia.edu/Documents/in/Erectile_dysfunction?f_ri=31958","nofollow":true},{"id":65171,"name":"Smooth muscle","url":"https://www.academia.edu/Documents/in/Smooth_muscle?f_ri=31958"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme?f_ri=31958"},{"id":274856,"name":"Phosphodiesterase Inhibitors","url":"https://www.academia.edu/Documents/in/Phosphodiesterase_Inhibitors?f_ri=31958"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=31958"},{"id":461924,"name":"Cyclic nucleotides","url":"https://www.academia.edu/Documents/in/Cyclic_nucleotides?f_ri=31958"},{"id":1200088,"name":"Second Messengers","url":"https://www.academia.edu/Documents/in/Second_Messengers?f_ri=31958"},{"id":1220176,"name":"Preterm Delivery","url":"https://www.academia.edu/Documents/in/Preterm_Delivery?f_ri=31958"},{"id":2454817,"name":"Inflammatory response","url":"https://www.academia.edu/Documents/in/Inflammatory_response?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_31286298" data-work_id="31286298" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/31286298/A_primary_care_provider_s_guide_to_preventive_and_acute_care_management_of_adults_and_children_with_sickle_cell_disease">A primary care provider’s guide to preventive and acute care management of adults and children with sickle cell disease</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/31286298" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c490aba5f908fed3876c536cb7a94ceb" rel="nofollow" data-download="{"attachment_id":51685849,"asset_id":31286298,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51685849/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="59782384" href="https://independent.academia.edu/ArdiePackMabien">Ardie Pack-Mabien</a><script data-card-contents-for-user="59782384" type="text/json">{"id":59782384,"first_name":"Ardie","last_name":"Pack-Mabien","domain_name":"independent","page_name":"ArdiePackMabien","display_name":"Ardie Pack-Mabien","profile_url":"https://independent.academia.edu/ArdiePackMabien?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_31286298 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="31286298"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 31286298, container: ".js-paper-rank-work_31286298", }); });</script></li><li class="js-percentile-work_31286298 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31286298; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_31286298"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_31286298 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="31286298"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31286298; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31286298]").text(description); $(".js-view-count-work_31286298").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_31286298").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="31286298"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="588" rel="nofollow" href="https://www.academia.edu/Documents/in/Nursing">Nursing</a>, <script data-card-contents-for-ri="588" type="text/json">{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2898" rel="nofollow" href="https://www.academia.edu/Documents/in/Pain">Pain</a>, <script data-card-contents-for-ri="2898" type="text/json">{"id":2898,"name":"Pain","url":"https://www.academia.edu/Documents/in/Pain?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2974" rel="nofollow" href="https://www.academia.edu/Documents/in/Primary_Health_Care">Primary Health Care</a>, <script data-card-contents-for-ri="2974" type="text/json">{"id":2974,"name":"Primary Health Care","url":"https://www.academia.edu/Documents/in/Primary_Health_Care?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="5569" rel="nofollow" href="https://www.academia.edu/Documents/in/Sickle_Cell_Anemia">Sickle Cell Anemia</a><script data-card-contents-for-ri="5569" type="text/json">{"id":5569,"name":"Sickle Cell Anemia","url":"https://www.academia.edu/Documents/in/Sickle_Cell_Anemia?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=31286298]'), work: {"id":31286298,"title":"A primary care provider’s guide to preventive and acute care management of adults and children with sickle cell disease","created_at":"2017-02-07T13:07:58.537-08:00","url":"https://www.academia.edu/31286298/A_primary_care_provider_s_guide_to_preventive_and_acute_care_management_of_adults_and_children_with_sickle_cell_disease?f_ri=31958","dom_id":"work_31286298","summary":null,"downloadable_attachments":[{"id":51685849,"asset_id":31286298,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":59782384,"first_name":"Ardie","last_name":"Pack-Mabien","domain_name":"independent","page_name":"ArdiePackMabien","display_name":"Ardie Pack-Mabien","profile_url":"https://independent.academia.edu/ArdiePackMabien?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=31958","nofollow":true},{"id":2898,"name":"Pain","url":"https://www.academia.edu/Documents/in/Pain?f_ri=31958","nofollow":true},{"id":2974,"name":"Primary Health Care","url":"https://www.academia.edu/Documents/in/Primary_Health_Care?f_ri=31958","nofollow":true},{"id":5569,"name":"Sickle Cell Anemia","url":"https://www.academia.edu/Documents/in/Sickle_Cell_Anemia?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958"},{"id":61234,"name":"Stroke","url":"https://www.academia.edu/Documents/in/Stroke?f_ri=31958"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=31958"},{"id":109739,"name":"Infection","url":"https://www.academia.edu/Documents/in/Infection?f_ri=31958"},{"id":164831,"name":"Dyspnea","url":"https://www.academia.edu/Documents/in/Dyspnea?f_ri=31958"},{"id":305410,"name":"Nurse Practitioners","url":"https://www.academia.edu/Documents/in/Nurse_Practitioners?f_ri=31958"},{"id":387144,"name":"Fever","url":"https://www.academia.edu/Documents/in/Fever?f_ri=31958"},{"id":1290159,"name":"Cholelithiasis","url":"https://www.academia.edu/Documents/in/Cholelithiasis?f_ri=31958"},{"id":1292329,"name":"Primary Prevention","url":"https://www.academia.edu/Documents/in/Primary_Prevention?f_ri=31958"},{"id":1329861,"name":"Priapism","url":"https://www.academia.edu/Documents/in/Priapism?f_ri=31958"},{"id":1863718,"name":"The American","url":"https://www.academia.edu/Documents/in/The_American?f_ri=31958"},{"id":2463800,"name":"Severity of Illness Index","url":"https://www.academia.edu/Documents/in/Severity_of_Illness_Index?f_ri=31958"},{"id":2471455,"name":"Acute Disease","url":"https://www.academia.edu/Documents/in/Acute_Disease?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_36935097" data-work_id="36935097" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/36935097/Factors_associated_with_early_deaths_following_neonatal_male_circumcision_in_the_United_States_2001_2010">Factors associated with early deaths following neonatal male circumcision in the United States, 2001-2010</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We sought to quantify early deaths following neonatal circumcision (same hospital admission) and to identify factors associated with such mortality. We performed a retrospective analysis of all patients who underwent circumcision while... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_36935097" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We sought to quantify early deaths following neonatal circumcision (same hospital admission) and to identify factors associated with such mortality. We performed a retrospective analysis of all patients who underwent circumcision while hospitalized during the first 30 days of life from 2001-2010 using the National Inpatient Sample (NIS). Over 10 years, 200 early deaths were recorded among 9,833,110 subjects (1 death per 49,166 circumcisions). Note: this figure should not be interpreted as causal but correlational: it may include both under-counting and over-counting of deaths attributable to circumcision. Compared to survivors, subjects who died following newborn circumcision were more likely to have associated co-morbid conditions, such as cardiac disease (OR: 697.8 [378.5-1286.6] p<0.001), coagulopathy (OR: 159.6 [95.6-266.2] p<0.001), fluid and electrolyte disorders (OR: 68.2 [49.1-94.6] p<0.001), or pulmonary circulatory disorders (OR: 169.5 [69.7-412.5] p<0.001). Recognizing these factors could inform clinical and parental decisions, potentially reducing associated risks.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/36935097" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a8924c37fd443ba6fadab95bce6359b6" rel="nofollow" data-download="{"attachment_id":57509490,"asset_id":36935097,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/57509490/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="377433" href="https://oxford.academia.edu/BrianDEarp">Brian D . 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We performed a retrospective analysis of all patients who underwent circumcision while hospitalized during the first 30 days of life from 2001-2010 using the National Inpatient Sample (NIS). Over 10 years, 200 early deaths were recorded among 9,833,110 subjects (1 death per 49,166 circumcisions). Note: this figure should not be interpreted as causal but correlational: it may include both under-counting and over-counting of deaths attributable to circumcision. Compared to survivors, subjects who died following newborn circumcision were more likely to have associated co-morbid conditions, such as cardiac disease (OR: 697.8 [378.5-1286.6] p\u003c0.001), coagulopathy (OR: 159.6 [95.6-266.2] p\u003c0.001), fluid and electrolyte disorders (OR: 68.2 [49.1-94.6] p\u003c0.001), or pulmonary circulatory disorders (OR: 169.5 [69.7-412.5] p\u003c0.001). Recognizing these factors could inform clinical and parental decisions, potentially reducing associated risks. 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href="https://www.academia.edu/20037546/Bosentan_in_der_P%C3%A4diatrie_Die_ideale_Arzneiform_in_der_klinischen_Studie">Bosentan in der Pädiatrie. Die ideale Arzneiform in der klinischen Studie</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Die pulmonale arterielle Hypertonie (PAH) ist bei Kindern ein seltenes Krankheitsbild. Aus der Gruppe der Endothelin-Antagonisten ist nur Bosentan für die Behandlung der PAH bei pädiatrischen Patienten indiziert. Das 2009 zugelassene... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20037546" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Die pulmonale arterielle Hypertonie (PAH) ist bei Kindern ein seltenes Krankheitsbild. Aus der Gruppe der Endothelin-Antagonisten ist nur Bosentan für die Behandlung der PAH bei pädiatrischen Patienten indiziert. Das 2009 zugelassene Produkt "Tracleer ® 32 mg Tabletten zur Herstellung einer Suspension zum Einnehmen" wird in einer speziellen Zubereitung für die pädiatrische Verwendung angeboten. 454 | Pharm. Unserer Zeit | 6/2010 (39)</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20037546" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="67c165bdb3f2a7bd3eb2bfcf960c3838" rel="nofollow" data-download="{"attachment_id":40970127,"asset_id":20037546,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40970127/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40974474" href="https://independent.academia.edu/J%C3%B6rgBreitkreutz">Jörg Breitkreutz</a><script data-card-contents-for-user="40974474" type="text/json">{"id":40974474,"first_name":"Jörg","last_name":"Breitkreutz","domain_name":"independent","page_name":"JörgBreitkreutz","display_name":"Jörg Breitkreutz","profile_url":"https://independent.academia.edu/J%C3%B6rgBreitkreutz?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_20037546 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20037546"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20037546, container: ".js-paper-rank-work_20037546", }); 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Die ideale Arzneiform in der klinischen Studie","created_at":"2016-01-05T07:16:19.468-08:00","url":"https://www.academia.edu/20037546/Bosentan_in_der_P%C3%A4diatrie_Die_ideale_Arzneiform_in_der_klinischen_Studie?f_ri=31958","dom_id":"work_20037546","summary":"Die pulmonale arterielle Hypertonie (PAH) ist bei Kindern ein seltenes Krankheitsbild. Aus der Gruppe der Endothelin-Antagonisten ist nur Bosentan für die Behandlung der PAH bei pädiatrischen Patienten indiziert. Das 2009 zugelassene Produkt \"Tracleer ® 32 mg Tabletten zur Herstellung einer Suspension zum Einnehmen\" wird in einer speziellen Zubereitung für die pädiatrische Verwendung angeboten. 454 | Pharm. Unserer Zeit | 6/2010 (39)","downloadable_attachments":[{"id":40970127,"asset_id":20037546,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":40974474,"first_name":"Jörg","last_name":"Breitkreutz","domain_name":"independent","page_name":"JörgBreitkreutz","display_name":"Jörg Breitkreutz","profile_url":"https://independent.academia.edu/J%C3%B6rgBreitkreutz?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=31958","nofollow":true},{"id":23390,"name":"Pharmaceutical Chemistry","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Chemistry?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=31958","nofollow":true},{"id":1135797,"name":"Dosage Forms","url":"https://www.academia.edu/Documents/in/Dosage_Forms?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16654372" data-work_id="16654372" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16654372/Dyspn%C3%A9e_%C3%A0_l_effort_chez_le_patient_atteint_de_scl%C3%A9rodermie_syst%C3%A9mique_du_sympt%C3%B4me_au_diagnostic_%C3%A9tiologique">Dyspnée à l’effort chez le patient atteint de sclérodermie systémique : du symptôme au diagnostic étiologique</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Pulmonary hypertension and interstitial lung disease are the two main causes of death in systemic sclerosis. The hallmark of these complications is dyspnea on exertion. Assessment of dyspnea in systemic sclerosis is based on a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16654372" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Pulmonary hypertension and interstitial lung disease are the two main causes of death in systemic sclerosis. The hallmark of these complications is dyspnea on exertion. Assessment of dyspnea in systemic sclerosis is based on a questionnaire; 6-minute walk test and Borg index. After excluding anemia, a deceptive cause mainly due to digestive haemorrhage, echocardiography, pulmonary function tests and high resolution computed tomography of the chest are the first step to diagnosis. Peak velocity of tricuspid regurgitation as measured by echocardiography is the main parameter to evaluate the risk of pulmonary hypertension before performing a right heart catheterization. Diastolic left ventricle dysfunction is another frequently encountered cause of dyspnea in systemic sclerosis. Other less common causes are pericarditis, respiratory muscle involvement, lung cancer, pulmonary embolism.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16654372" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4f44df57ac9c10df331649f4e3ec60b1" rel="nofollow" data-download="{"attachment_id":42420936,"asset_id":16654372,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42420936/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36012250" href="https://univ-lille.academia.edu/PascaldeGroote">Pascal de Groote</a><script data-card-contents-for-user="36012250" type="text/json">{"id":36012250,"first_name":"Pascal de","last_name":"Groote","domain_name":"univ-lille","page_name":"PascaldeGroote","display_name":"Pascal de Groote","profile_url":"https://univ-lille.academia.edu/PascaldeGroote?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16654372 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16654372"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16654372, container: ".js-paper-rank-work_16654372", }); 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$(".js-view-count[data-work-id=16654372]").text(description); $(".js-view-count-work_16654372").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16654372").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16654372"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="428" rel="nofollow" href="https://www.academia.edu/Documents/in/Algorithms">Algorithms</a>, <script data-card-contents-for-ri="428" type="text/json">{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="44529" rel="nofollow" href="https://www.academia.edu/Documents/in/Activities_of_Daily_Living">Activities of Daily Living</a>, <script data-card-contents-for-ri="44529" type="text/json">{"id":44529,"name":"Activities of Daily Living","url":"https://www.academia.edu/Documents/in/Activities_of_Daily_Living?f_ri=31958","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="46824" rel="nofollow" href="https://www.academia.edu/Documents/in/Echocardiography">Echocardiography</a><script data-card-contents-for-ri="46824" type="text/json">{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=31958","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16654372]'), work: {"id":16654372,"title":"Dyspnée à l’effort chez le patient atteint de sclérodermie systémique : du symptôme au diagnostic étiologique","created_at":"2015-10-11T05:16:53.607-07:00","url":"https://www.academia.edu/16654372/Dyspn%C3%A9e_%C3%A0_l_effort_chez_le_patient_atteint_de_scl%C3%A9rodermie_syst%C3%A9mique_du_sympt%C3%B4me_au_diagnostic_%C3%A9tiologique?f_ri=31958","dom_id":"work_16654372","summary":"Pulmonary hypertension and interstitial lung disease are the two main causes of death in systemic sclerosis. The hallmark of these complications is dyspnea on exertion. Assessment of dyspnea in systemic sclerosis is based on a questionnaire; 6-minute walk test and Borg index. After excluding anemia, a deceptive cause mainly due to digestive haemorrhage, echocardiography, pulmonary function tests and high resolution computed tomography of the chest are the first step to diagnosis. Peak velocity of tricuspid regurgitation as measured by echocardiography is the main parameter to evaluate the risk of pulmonary hypertension before performing a right heart catheterization. Diastolic left ventricle dysfunction is another frequently encountered cause of dyspnea in systemic sclerosis. Other less common causes are pericarditis, respiratory muscle involvement, lung cancer, pulmonary embolism.","downloadable_attachments":[{"id":42420936,"asset_id":16654372,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36012250,"first_name":"Pascal de","last_name":"Groote","domain_name":"univ-lille","page_name":"PascaldeGroote","display_name":"Pascal de Groote","profile_url":"https://univ-lille.academia.edu/PascaldeGroote?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=31958","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":44529,"name":"Activities of Daily Living","url":"https://www.academia.edu/Documents/in/Activities_of_Daily_Living?f_ri=31958","nofollow":true},{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=31958","nofollow":true},{"id":53338,"name":"Decision Trees","url":"https://www.academia.edu/Documents/in/Decision_Trees?f_ri=31958"},{"id":136346,"name":"Anemia","url":"https://www.academia.edu/Documents/in/Anemia?f_ri=31958"},{"id":162159,"name":"Differential Diagnosis","url":"https://www.academia.edu/Documents/in/Differential_Diagnosis?f_ri=31958"},{"id":164831,"name":"Dyspnea","url":"https://www.academia.edu/Documents/in/Dyspnea?f_ri=31958"},{"id":198747,"name":"Left Ventricular Dysfunction","url":"https://www.academia.edu/Documents/in/Left_Ventricular_Dysfunction?f_ri=31958"},{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=31958"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=31958"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=31958"},{"id":1146831,"name":"Exercise Test","url":"https://www.academia.edu/Documents/in/Exercise_Test?f_ri=31958"},{"id":1210716,"name":"Exercise Tolerance","url":"https://www.academia.edu/Documents/in/Exercise_Tolerance?f_ri=31958"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13128430" data-work_id="13128430" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13128430/Anesth%C3%A9sie_et_insuffisance_cardiaque_droite">Anesthésie et insuffisance cardiaque droite</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Reçu le 21 octobre 2008 ; accepté le 21 juillet 2009 Résumé Objectif. -Mise au point sur la prise en charge anesthésique périopératoire d'un patient porteur d'une insuffisance ventriculaire droite (IVD). Acquisition des données. -Les... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13128430" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Reçu le 21 octobre 2008 ; accepté le 21 juillet 2009 Résumé Objectif. -Mise au point sur la prise en charge anesthésique périopératoire d'un patient porteur d'une insuffisance ventriculaire droite (IVD). Acquisition des données. -Les articles principaux et plus particulièrement ceux publiés au cours des cinq dernières années et indexés dans la base de données Medline 1 ont été analysés. Synthèse des données. -La consultation de préanesthésie doit permettre d'identifier l'étiologie de l'IVD, d'évaluer la réserve fonctionnelle du patient, de planifier les examens complémentaires adéquats et d'informer le patient sur les risques encourus. En peropératoire, le monitorage dépend de la gravité de la pathologie du patient ; dans tous les cas un monitorage invasif de la pression artérielle est nécessaire. Particulièrement chez ces patients, l'anesthésie doit être conduite en évitant toute variation hémodynamique. Le risque de décès est important durant les premiers jours postopératoires ; la prise en charge postopératoire est idéalement faite en unité de soins intensifs. Conclusion. -L'insuffisance ventriculaire droite est une pathologie souvent méconnue et pourtant pourvoyeuse d'une morbimortalité non négligeable. Dès la période préopératoire, l'anesthésiste doit identifier les patients à risque pour pouvoir adapter la stratégie de prise en charge à leur pathologie. # 2009 Publié par Elsevier Masson SAS.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13128430" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8111487d71f8394c485f19bfbbf9acf5" rel="nofollow" data-download="{"attachment_id":45675185,"asset_id":13128430,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45675185/download_file?st=MTczOTgwNTU3Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32385049" href="https://univ-paris7.academia.edu/EtienneGayat">Etienne Gayat</a><script data-card-contents-for-user="32385049" type="text/json">{"id":32385049,"first_name":"Etienne","last_name":"Gayat","domain_name":"univ-paris7","page_name":"EtienneGayat","display_name":"Etienne Gayat","profile_url":"https://univ-paris7.academia.edu/EtienneGayat?f_ri=31958","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13128430 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13128430"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13128430, container: ".js-paper-rank-work_13128430", }); 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accepté le 21 juillet 2009 Résumé Objectif. -Mise au point sur la prise en charge anesthésique périopératoire d'un patient porteur d'une insuffisance ventriculaire droite (IVD). Acquisition des données. -Les articles principaux et plus particulièrement ceux publiés au cours des cinq dernières années et indexés dans la base de données Medline 1 ont été analysés. Synthèse des données. -La consultation de préanesthésie doit permettre d'identifier l'étiologie de l'IVD, d'évaluer la réserve fonctionnelle du patient, de planifier les examens complémentaires adéquats et d'informer le patient sur les risques encourus. En peropératoire, le monitorage dépend de la gravité de la pathologie du patient ; dans tous les cas un monitorage invasif de la pression artérielle est nécessaire. Particulièrement chez ces patients, l'anesthésie doit être conduite en évitant toute variation hémodynamique. Le risque de décès est important durant les premiers jours postopératoires ; la prise en charge postopératoire est idéalement faite en unité de soins intensifs. Conclusion. -L'insuffisance ventriculaire droite est une pathologie souvent méconnue et pourtant pourvoyeuse d'une morbimortalité non négligeable. Dès la période préopératoire, l'anesthésiste doit identifier les patients à risque pour pouvoir adapter la stratégie de prise en charge à leur pathologie. # 2009 Publié par Elsevier Masson SAS.","downloadable_attachments":[{"id":45675185,"asset_id":13128430,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32385049,"first_name":"Etienne","last_name":"Gayat","domain_name":"univ-paris7","page_name":"EtienneGayat","display_name":"Etienne Gayat","profile_url":"https://univ-paris7.academia.edu/EtienneGayat?f_ri=31958","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=31958","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=31958","nofollow":true},{"id":88321,"name":"Blood 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