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var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1739836611000); window.Aedu.timeDifference = new Date().getTime() - 1739836611000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"ObjectivesTo study the safety and efficacy of topical bevacizumab in the treatment of corneal neovascularization (NV).DesignIn a prospective, open-label, non-comparative study, 10 eyes from 10 patients with stable corneal NV were treated with topical bevacizumab 1.0% for 3 weeks and followed up to 24 weeks.Main Outcome MeasuresThe primary safety variables were the occurrence of ocular and systemic adverse events throughout the course of the study. The primary efficacy variables were neovascular area (NA), measuring the area of the corneal vessels themselves; vessel caliber (VC), measuring the mean diameter of the corneal vessels; and invasion area (IA), measuring the fraction of the total corneal area covered by the vessels.ResultsFrom baseline visit to the last follow-up visit, the mean reduction was 47.1% ± 36.7% for NA, 54.1% ± 28.1 for VC, and 12.2% ± 42.0% for IA. The decreases in NA and VC were statistically significant (p = 0.0014 and p = 0.00009, respectively). However, changes in IA did not achieve statistical significance (p = 0.19). Visual acuity and central corneal thickness showed no significant changes. Topical bevacizumab was well-tolerated with no adverse events.ConclusionsShort-term topical bevacizumab therapy reduces the severity of corneal NV without local or systemic side-effects.Application to Clinical PracticeTopical bevacizumab provides an alternative therapy in the treatment of stable corneal neovascularization.Trial Registrationclinicaltrials.gov Identifier: {\u0026amp;quot;type\u0026amp;quot;:\u0026amp;quot;clinical-trial\u0026amp;quot;,\u0026amp;quot;attrs\u0026amp;quot;:{\u0026amp;quot;text\u0026amp;quot;:\u0026amp;quot;NCT00559936\u0026amp;quot;,\u0026amp;quot;term_id\u0026amp;quot;:\u0026amp;quot;NCT00559936\u0026amp;quot;}}NCT00559936","author":[{"@context":"https://schema.org","@type":"Person","name":"Khalid Alarfaj","url":"https://iabfu.academia.edu/KhalidAlarfaj"}],"contributor":[],"dateCreated":"2021-11-10","dateModified":"2021-11-10","datePublished":"2009-01-01","headline":"Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, non-comparative study","image":"https://attachments.academia-assets.com/74498600/thumbnails/1.jpg","inLanguage":"en","keywords":["Ophthalmology","Archives","Treatment","Treatment Outcome","Visual acuity","Prospective studies","Humans","Female","Male","Monoclonal Antibodies","Aged","Middle Aged","Optometry and Ophthalmology","Topical Drug Administration","Adult","Ophthalmic Solutions","Corneal neovascularization","Angiogenesis inhibitors"],"publication":"Archives of …","publisher":{"@context":"https://schema.org","@type":"Organization","name":"ncbi.nlm.nih.gov"},"sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"iabfu"}],"thumbnailUrl":"https://attachments.academia-assets.com/74498600/thumbnails/1.jpg","url":"https://www.academia.edu/61479077/Topical_bevacizumab_in_the_treatment_of_corneal_neovascularization_results_of_a_prospective_open_label_non_comparative_study"}</script><style type="text/css">@media(max-width: 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= true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":61479077,"created_at":"2021-11-10T10:16:35.432-08:00","from_world_paper_id":183614010,"updated_at":"2021-11-10T10:38:42.705-08:00","_data":{"abstract":"ObjectivesTo study the safety and efficacy of topical bevacizumab in the treatment of corneal neovascularization (NV).DesignIn a prospective, open-label, non-comparative study, 10 eyes from 10 patients with stable corneal NV were treated with topical bevacizumab 1.0% for 3 weeks and followed up to 24 weeks.Main Outcome MeasuresThe primary safety variables were the occurrence of ocular and systemic adverse events throughout the course of the study. The primary efficacy variables were neovascular area (NA), measuring the area of the corneal vessels themselves; vessel caliber (VC), measuring the mean diameter of the corneal vessels; and invasion area (IA), measuring the fraction of the total corneal area covered by the vessels.ResultsFrom baseline visit to the last follow-up visit, the mean reduction was 47.1% ± 36.7% for NA, 54.1% ± 28.1 for VC, and 12.2% ± 42.0% for IA. The decreases in NA and VC were statistically significant (p = 0.0014 and p = 0.00009, respectively). However, changes in IA did not achieve statistical significance (p = 0.19). Visual acuity and central corneal thickness showed no significant changes. Topical bevacizumab was well-tolerated with no adverse events.ConclusionsShort-term topical bevacizumab therapy reduces the severity of corneal NV without local or systemic side-effects.Application to Clinical PracticeTopical bevacizumab provides an alternative therapy in the treatment of stable corneal neovascularization.Trial Registrationclinicaltrials.gov Identifier: {\"type\":\"clinical-trial\",\"attrs\":{\"text\":\"NCT00559936\",\"term_id\":\"NCT00559936\"}}NCT00559936","publisher":"ncbi.nlm.nih.gov","publication_date":"2009,,","publication_name":"Archives of …"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, non-comparative study","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [260145]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":74498600,"attachmentType":"pdf"}"><img alt="First page of “Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, non-comparative study”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/74498600/mini_magick20211110-2133-1artozc.png?1636568240" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, non-comparative study</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="260145" href="https://iabfu.academia.edu/KhalidAlarfaj"><img alt="Profile image of Khalid Alarfaj" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Khalid Alarfaj</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2009, Archives of …</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">16 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 61479077; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=61479077"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">ObjectivesTo study the safety and efficacy of topical bevacizumab in the treatment of corneal neovascularization (NV).DesignIn a prospective, open-label, non-comparative study, 10 eyes from 10 patients with stable corneal NV were treated with topical bevacizumab 1.0% for 3 weeks and followed up to 24 weeks.Main Outcome MeasuresThe primary safety variables were the occurrence of ocular and systemic adverse events throughout the course of the study. The primary efficacy variables were neovascular area (NA), measuring the area of the corneal vessels themselves; vessel caliber (VC), measuring the mean diameter of the corneal vessels; and invasion area (IA), measuring the fraction of the total corneal area covered by the vessels.ResultsFrom baseline visit to the last follow-up visit, the mean reduction was 47.1% ± 36.7% for NA, 54.1% ± 28.1 for VC, and 12.2% ± 42.0% for IA. The decreases in NA and VC were statistically significant (p = 0.0014 and p = 0.00009, respectively). However, changes in IA did not achieve statistical significance (p = 0.19). Visual acuity and central corneal thickness showed no significant changes. Topical bevacizumab was well-tolerated with no adverse events.ConclusionsShort-term topical bevacizumab therapy reduces the severity of corneal NV without local or systemic side-effects.Application to Clinical PracticeTopical bevacizumab provides an alternative therapy in the treatment of stable corneal neovascularization.Trial Registrationclinicaltrials.gov Identifier: {"type":"clinical-trial","attrs":{"text":"NCT00559936","term_id":"NCT00559936"}}NCT00559936</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":74498600,"attachmentType":"pdf","workUrl":"https://www.academia.edu/61479077/Topical_bevacizumab_in_the_treatment_of_corneal_neovascularization_results_of_a_prospective_open_label_non_comparative_study"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":74498600,"attachmentType":"pdf","workUrl":"https://www.academia.edu/61479077/Topical_bevacizumab_in_the_treatment_of_corneal_neovascularization_results_of_a_prospective_open_label_non_comparative_study"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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Design-In a prospective, open-label, non-comparative study, 10 eyes from 10 patients with stable corneal NV were treated with topical bevacizumab 1.0% for 3 weeks and followed up to 24 weeks. Main Outcome Measures-The primary safety variables were the occurrence of ocular and systemic adverse events throughout the course of the study. The primary efficacy variables were neovascular area (NA), measuring the area of the corneal vessels themselves; vessel caliber (VC), measuring the mean diameter of the corneal vessels; and invasion area (IA), measuring the fraction of the total corneal area covered by the vessels. Results-From baseline visit to the last follow-up visit, the mean reduction was 47.1% ± 36.7% for NA, 54.1% ± 28.1 for VC, and 12.2% ± 42.0% for IA. The decreases in NA and VC were statistically significant (p = 0.0014 and p = 0.00009, respectively). However, changes in IA did not achieve statistical significance (p = 0.19). Visual acuity and central corneal thickness showed no significant changes. Topical bevacizumab was well-tolerated with no adverse events. Conclusions-Short-term topical bevacizumab therapy reduces the severity of corneal NV without local or systemic side-effects. Application to Clinical Practice-Topical bevacizumab provides an alternative therapy in the treatment of stable corneal neovascularization. Trial Registration-clinicaltrials.gov Identifier: NCT00559936 The cornea has the unique feature (except for cartilage) of being normally avascular, but under pathologic conditions vessels invade the cornea from the limbal vascular plexus. A wide variety of insults including infection, inflammation, ischemia, degeneration, trauma, and loss of the limbal stem cell barrier can cause corneal neovascularization (NV). 1 Although corneal NV can occasionally serve a beneficial role in the clearing of infections, wound healing, and in arresting stromal melts, 2 its disadvantages are numerous. Corneal NV often leads to tissue scarring,</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Topical Bevacizumab in the Treatment of Corneal Neovascularization","attachmentId":83736945,"attachmentType":"pdf","work_url":"https://www.academia.edu/76051958/Topical_Bevacizumab_in_the_Treatment_of_Corneal_Neovascularization","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/76051958/Topical_Bevacizumab_in_the_Treatment_of_Corneal_Neovascularization"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="76051956" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/76051956/Short_Term_Topical_Bevacizumab_in_the_Treatment_of_Stable_Corneal_Neovascularization">Short-Term Topical Bevacizumab in the Treatment of Stable Corneal Neovascularization</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58073595" href="https://independent.academia.edu/MDastjerdi">Mohammad Dastjerdi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Ophthalmology, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">Purpose-To evaluate the safety and efficacy of topical bevacizumab in the treatment of corneal neovascularization (NV). Design-Prospective, non-randomized, interventional case series. Study Population-Twenty eyes from 20 patients with stable corneal NV. Intervention Procedures-Patients were treated with topical 1.0% for 3 weeks and monitored for a total of 24 weeks. Main Outcome Measures-Primary outcome measures included: neovascular area, defined as the area of the corneal vessels themselves; vessel caliber, defined as the mean corneal vessel diameter; and invasion area, defined as the fraction of the total cornea into which the vessels extended. The occurrence of ocular and systemic adverse events was closely monitored.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Short-Term Topical Bevacizumab in the Treatment of Stable Corneal Neovascularization","attachmentId":83738574,"attachmentType":"pdf","work_url":"https://www.academia.edu/76051956/Short_Term_Topical_Bevacizumab_in_the_Treatment_of_Stable_Corneal_Neovascularization","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/76051956/Short_Term_Topical_Bevacizumab_in_the_Treatment_of_Stable_Corneal_Neovascularization"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="73026747" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/73026747/The_Effect_of_Topical_Bevacizumab_on_Corneal_Neovasularization_in_a_Rabbit_Model">The Effect of Topical Bevacizumab on Corneal Neovasularization in a Rabbit Model</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="55060323" href="https://independent.academia.edu/kasiriali">ali kasiri</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Objectives: To evaluate the effect of topical bevacizumab for treatment of the corneal neovascularization (CNV) in a rabbit model of corneal injury. Methods: Corneal neovascularization was induced by 3 sutures of the cornea in 20 rabbits (20 corneas). Two weeks later all sutures have been removed then rabbits were divided randomly into 2 groups: group 1 received topical bevacizumab at 10 mg/mL and group 2 received only topical normal salin drops as control group, in the right eyes three times a day for two weeks. Photographs of (CNV) were obtained before drug administration and at 1 and 2 weeks after therapy. The images were analyzed using NIH Image J 1.49c software. Results: The mean percentage of CNV area estimated as 100 % before treatment. At the 1 week after treatment, the mean percentage of neovascularization area in Bevacizumab and Salin group were 75.64±4.32 and 93.33±4.57 respectively. Also at the 2 week after treatment were 61.45±6.18 and 84.96±5.21 respectively. After one...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Effect of Topical Bevacizumab on Corneal Neovasularization in a Rabbit Model","attachmentId":81712638,"attachmentType":"pdf","work_url":"https://www.academia.edu/73026747/The_Effect_of_Topical_Bevacizumab_on_Corneal_Neovasularization_in_a_Rabbit_Model","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/73026747/The_Effect_of_Topical_Bevacizumab_on_Corneal_Neovasularization_in_a_Rabbit_Model"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="24138850" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24138850/Prevention_of_Corneal_Neovascularization_Comparison_of_Different_Doses_of_Subconjunctival_Bevacizumab_with_Its_Topical_Form_in_Experimental_Rats">Prevention of Corneal Neovascularization: Comparison of Different Doses of Subconjunctival Bevacizumab with Its Topical Form in Experimental Rats</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="46559123" href="https://independent.academia.edu/MaryamTahvildari">Maryam Tahvildari</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Ophthalmic Research, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">25 mg/ml of bevacizumab in the fourth group increased the avascular area more than twofold, compared with the salinetreated group (32.2% compared with 15%, p ! 0.001). This difference between groups 4 and 2 was statistically significant (p = 0.04). Although topical delivery of 25 mg/ml bevacizumab was effective to inhibit CNV (p = 0.004), the results were similar to those of the third group. Qualitative microscopic evaluation of the cornea was compatible with the gross findings, as bevacizumab-treated groups had less intense corneal vessel channels and inflammation. Conclusion: Both subconjunctival and topical bevacizumab can prevent CNV in rats.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prevention of Corneal Neovascularization: Comparison of Different Doses of Subconjunctival Bevacizumab with Its Topical Form in Experimental Rats","attachmentId":44494816,"attachmentType":"pdf","work_url":"https://www.academia.edu/24138850/Prevention_of_Corneal_Neovascularization_Comparison_of_Different_Doses_of_Subconjunctival_Bevacizumab_with_Its_Topical_Form_in_Experimental_Rats","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/24138850/Prevention_of_Corneal_Neovascularization_Comparison_of_Different_Doses_of_Subconjunctival_Bevacizumab_with_Its_Topical_Form_in_Experimental_Rats"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="4732458" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4732458/Short_and_long_term_safety_profile_and_efficacy_of_topical_bevacizumab_Avastin_eye_drops_against_corneal_neovascularization">Short and long-term safety profile and efficacy of topical bevacizumab (Avastin ® ) eye drops against corneal neovascularization</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="6055587" href="https://independent.academia.edu/FelixGrey">Felix Grey</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Graefes Archive for Clinical and Experimental Ophthalmology, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">Purpose To evaluate the short- and long-term in vivo safety and efficacy of topical bevacizumab (Avastin) application for treatment of corneal neovascularization secondary to a variety of corneal diseases. Methods Thirty eyes of 27 patients with progressive corneal neovascularisation (not responding to conventional anti-inflammatory treatment) due to different underlying corneal diseases received topical bevacizumab (Avastin) eye drops (5 mg/ml Bevacizumab) for 0.5–12 months (five times/day on average). At each visit, a routine Snellen visual acuity assessment was performed, followed by ophthalmic examination including fluorescein staining. Changes of corneal neovascularization and vessel diameter were assessed using morphometry of standardized digital corneal photographs. Results Five patients (five eyes) developed new corneal epithelial defects during topical bevacizumab treatment. In 22 patients, no new epithelial defects were observed. None of the 27 patients complained about any drug-related ocular or systemic adverse events during follow-up. No allergic reactions were observed. Corneal photographs of 21 eyes (19 patients) could be assessed. The mean reduction in vascularized area during treatment was 61%. The mean reduction in vessel diameter under topical Avastin therapy was 24%. Conclusions Off-label topical bevacizumab therapy against corneal neovascularization secondary to different corneal diseases was generally well-tolerated for up to 12 months. Bevacizumab (Avastin) eye drops inhibit corneal neovascularization, and lead to a reduction of the vessel diameter. Our results suggest that off-label use of Bevacizumab eye drops is a relatively safe and well-tolerated option for the treatment of corneal neovascularization. Care should be taken in patients with epithelial defects and neurotrophic keratopathy.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Short and long-term safety profile and efficacy of topical bevacizumab (Avastin ® ) eye drops against corneal neovascularization","attachmentId":49656635,"attachmentType":"pdf","work_url":"https://www.academia.edu/4732458/Short_and_long_term_safety_profile_and_efficacy_of_topical_bevacizumab_Avastin_eye_drops_against_corneal_neovascularization","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/4732458/Short_and_long_term_safety_profile_and_efficacy_of_topical_bevacizumab_Avastin_eye_drops_against_corneal_neovascularization"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="93827717" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/93827717/Effects_of_topical_and_subconjunctival_use_of_bevacizumab_on_corneal_neovascularization_in_rabbits_eyes">Effects of topical and subconjunctival use of bevacizumab on corneal neovascularization in rabbits' eyes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44720896" href="https://independent.academia.edu/AnaPaulaMiyaguskoTabaOguido">Ana Paula Miyagusko Taba Oguido</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Arquivos brasileiros de oftalmologia</p><p class="ds-related-work--abstract ds2-5-body-sm">To evaluate and compare the effects of topical application and subconjunctival injection of bevacizumab on corneal neovascularization (CNV) in rabbits&#39; eyes after chemical burning of the cornea. The animals were randomly distributed into four groups of five animals. In one group, the drug was instilled, while in another, it was administered by subconjunctival injection. The two procedures using bevacizumab were compared with instillation and subconjunctival injection of saline solution (S). Neovascularization was evaluated according to the size of the invasion area of new blood vessels and through computerized analysis of this area. The data were analyzed using the Kruskal-Wallis test followed by Dunn&#39;s test for two-by-two comparison of the groups, to assess the external examination of CNV. Analysis of variance was used to assess the area of CNV. P&lt;0.05 was considered statistically significant. Assessing both the external examination and the invasion area of neovessels on...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effects of topical and subconjunctival use of bevacizumab on corneal neovascularization in rabbits' eyes","attachmentId":96457479,"attachmentType":"pdf","work_url":"https://www.academia.edu/93827717/Effects_of_topical_and_subconjunctival_use_of_bevacizumab_on_corneal_neovascularization_in_rabbits_eyes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/93827717/Effects_of_topical_and_subconjunctival_use_of_bevacizumab_on_corneal_neovascularization_in_rabbits_eyes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="26844640" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26844640/Inhibition_of_Corneal_Neovascularization_by_Subconjunctival_and_Topical_Bevacizumab_and_Sunitinib_in_a_Rabbit_Model">Inhibition of Corneal Neovascularization by Subconjunctival and Topical Bevacizumab and Sunitinib in a Rabbit Model</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50841261" href="https://independent.academia.edu/RabiaSakarya">Rabia Sakarya</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cornea, 2013</p><p class="ds-related-work--abstract ds2-5-body-sm">Purpose: To compare the effects of subconjunctival injection and topical application of bevacizumab and sunitinib on experimentally induced corneal neovascularization (CNV).</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Inhibition of Corneal Neovascularization by Subconjunctival and Topical Bevacizumab and Sunitinib in a Rabbit Model","attachmentId":47114773,"attachmentType":"pdf","work_url":"https://www.academia.edu/26844640/Inhibition_of_Corneal_Neovascularization_by_Subconjunctival_and_Topical_Bevacizumab_and_Sunitinib_in_a_Rabbit_Model","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26844640/Inhibition_of_Corneal_Neovascularization_by_Subconjunctival_and_Topical_Bevacizumab_and_Sunitinib_in_a_Rabbit_Model"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="48677250" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/48677250/Inhibition_of_Corneal_Neovascularization_by_Subconjunctival_Bevacizumab_in_an_Animal_Model">Inhibition of Corneal Neovascularization by Subconjunctival Bevacizumab in an Animal Model</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33336977" href="https://johnshopkins.academia.edu/PeterGehlbach">Peter Gehlbach</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Ophthalmology, 2008</p><p class="ds-related-work--abstract ds2-5-body-sm">The aim of this study was to evaluate the effects of subconjunctival ranibizumab and bevacizumab injection on angiogenesis in the rabbit cornea. The corneas of 24 New Zealand rabbits were cauterized with silver nitrate to induce neovascularization. The eyes were irrigated with 10 ml of 0.9% saline solution. The alkaline burns were similar in all the rabbits. At the 24 h after cauterization, the rabbits were divided into three groups of eight animals each: The first group (GC) received 0.02 ml 0.9% saline solution as a control group whereas second (GR) and third (GB) groups received 0.5 mg ranibizumab and 1.25 mg bevacizumab by subconjunctival injection, respectively, on days first and 7 after lesion. The rabbits' corneas were extracted on the 14th day. Digital photographs of the corneas were obtained and the newly formed vessels were analyzed in a computerized system (google sketch-up program). The rates of these vessels were compared between the groups. Ranibizumab and bevacizumab were both effective on inhibition of angiogenesis, in comparison to 0.9% saline solution (P<0.05). Ranibizumab was found to be statistically more effective to reduce corneal neovascularization than bevacizumab (P<0.05). Bevacizumab and ranibizumab were found to be effective in inhibiting the corneal neovascularization in the rabbit cornea. Ranibizumab seemed more effective than bevacizumab on inhibiting corneal neovascularization in the rabbit cornea.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Inhibition of Corneal Neovascularization by Subconjunctival Bevacizumab in an Animal Model","attachmentId":67165966,"attachmentType":"pdf","work_url":"https://www.academia.edu/48677250/Inhibition_of_Corneal_Neovascularization_by_Subconjunctival_Bevacizumab_in_an_Animal_Model","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/48677250/Inhibition_of_Corneal_Neovascularization_by_Subconjunctival_Bevacizumab_in_an_Animal_Model"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="18516021" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18516021/Subconjunctival_Bevacizumab_Injection_for_Corneal_Neovascularization">Subconjunctival Bevacizumab Injection for Corneal Neovascularization</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38533355" href="https://independent.academia.edu/DavidRootman">David Rootman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cornea, 2008</p><p class="ds-related-work--abstract ds2-5-body-sm">Purpose: To report on the clinical use of subconjunctival bevacizumab in patients with corneal neovascularization.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Subconjunctival Bevacizumab Injection for Corneal Neovascularization","attachmentId":40106320,"attachmentType":"pdf","work_url":"https://www.academia.edu/18516021/Subconjunctival_Bevacizumab_Injection_for_Corneal_Neovascularization","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18516021/Subconjunctival_Bevacizumab_Injection_for_Corneal_Neovascularization"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="85598570" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/85598570/Intrastromal_injection_of_bevacizumab_in_patients_with_corneal_neovascularization">Intrastromal injection of bevacizumab in patients with corneal neovascularization</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="130963840" href="https://independent.academia.edu/MichelEidFarah">Michel Eid Farah</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Arquivos Brasileiros de Oftalmologia, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">Corneal neovascularization (NV) not only reduces visual acuity, but it also causes loss of the cornea's immune privilege, strongly contributing to a worse prognosis in penetrating keratoplasty. Several mediators participate in corneal angiogenesis, and the role of vascular endothelial growth factor (VEGF) has been extensively proven. AntiVEGF agents have been shown to be effective in slowing the growth of corneal neovessels. Bevacizumab, an antiVEGF agent, has been successfully used in the treatment of corneal neovascularization. In this paper, we report a series of patients who underwent intracorneal bevacizumab injections to treat corneal vascularization.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Intrastromal injection of bevacizumab in patients with corneal neovascularization","attachmentId":90246669,"attachmentType":"pdf","work_url":"https://www.academia.edu/85598570/Intrastromal_injection_of_bevacizumab_in_patients_with_corneal_neovascularization","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/85598570/Intrastromal_injection_of_bevacizumab_in_patients_with_corneal_neovascularization"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":74498600,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":74498600,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_74498600" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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js-related-work-sidebar-card" data-collection-position="3" data-entity-id="105133686" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/105133686/Can_Subconjunctival_Bevacizumab_Injection_Regress_Corneal_Neovascularization">Can Subconjunctival Bevacizumab Injection Regress Corneal Neovascularization?</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="272865182" href="https://independent.academia.edu/Zeynep%C3%96zbek19">Zeynep Özbek</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Can Subconjunctival Bevacizumab Injection Regress Corneal 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