BioFulcrum Viral and Infectious Disease Research Program

<!DOCTYPE html> <html lang="en" dir="ltr"> <head> <script src="https://kit.fontawesome.com/02ee16b563.js" crossorigin="anonymous"></script> <script> window.dataLayer = window.dataLayer || []; window.dataLayer.push({ 'event': 'dataLayer-initialized', 'userType': '' }); </script>  <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-K92GBK5');</script>  <meta charset="utf-8" /> <noscript><style>form.antibot * :not(.antibot-message) { display: none !important; }</style> </noscript><meta name="description" content="So far, antiviral drugs have been developed to target specific proteins produced by pathogens. This “one bug, one drug” approach can be highly effective initially, but the stupendous rate of replication and mutation of viral genomes can quickly lead to resistance. The same is true for antimicrobial drugs targeting bacteria, where we battle increased resistance to available antibiotics." /> <link rel="canonical" href="https://gladstone.org/science/biofulcrum-viral-and-infectious-disease-research-program" /> <link rel="image_src" href="https://gladstone.org/sites/default/files/GladstoneShareImg2.jpg" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@GladstoneInst" /> <meta name="twitter:description" content="So far, antiviral drugs have been developed to target specific proteins produced by pathogens. This “one bug, one drug” approach can be highly effective initially, but the stupendous rate of replication and mutation of viral genomes can quickly lead to resistance. The same is true for antimicrobial drugs targeting bacteria, where we battle increased resistance to available antibiotics." /> <meta name="twitter:title" content="BioFulcrum Viral and Infectious Disease Research Program" /> <meta name="twitter:image" content="https://gladstone.org/sites/default/files/GladstoneShareImg2.jpg" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" id="viewport" content="width=device-width, initial-scale=1, user-scalable=yes" /> <link rel="icon" href="/sites/default/files/Social-Media_0.png" type="image/png" /> <title>BioFulcrum Viral and Infectious Disease Research Program | Gladstone Institutes</title> <link rel="stylesheet" media="all" href="/modules/contrib/ajax_loader/css/throbber-general.css?sndln6" /> <link rel="stylesheet" media="all" href="/libraries/drupal-superfish/css/superfish.css?sndln6" /> <link rel="stylesheet" media="all" href="/modules/custom/miniorange_saml/css/miniorange_saml.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/core/components/progress.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/core/components/ajax-progress.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/align.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/fieldgroup.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/container-inline.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/clearfix.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/details.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/hidden.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/item-list.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/js.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/nowrap.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/position-container.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/reset-appearance.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/resize.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/system-status-counter.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/system-status-report-counters.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/system-status-report-general-info.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/tablesort.module.css?sndln6" /> <link rel="stylesheet" media="all" href="/sites/default/files/css/responsive_menu_breakpoint.css?sndln6" /> <link rel="stylesheet" media="all" href="/libraries/mmenu/dist/mmenu.css?sndln6" /> <link rel="stylesheet" media="all" href="/modules/contrib/responsive_menu/css/responsive_menu.css?sndln6" /> <link rel="stylesheet" media="all" href="/modules/contrib/ajax_loader/css/three-bounce.css?sndln6" /> <link rel="stylesheet" media="all" href="/libraries/glightbox/dist/css/glightbox.min.css?sndln6" /> <link rel="stylesheet" media="all" href="/modules/contrib/simple_popup_blocks/css/simple_popup_blocks.css?sndln6" /> <link rel="stylesheet" media="all" href="/modules/contrib/extlink/css/extlink.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/core/assets/vendor/normalize-css/normalize.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/core/normalize-fixes.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/base/layout.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/base/typography.css?sndln6" /> <link rel="stylesheet" media="all" href="//maxcdn.bootstrapcdn.com/bootstrap/3.3.7/css/bootstrap.min.css" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/base/elements.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/base/local-base.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/progress.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/action-links.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/button.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/collapse-processed.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/container-inline.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/details.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/exposed-filters.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/field.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/form.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/icons.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/inline-form.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/item-list.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/link.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/links.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/menu.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/more-link.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/tabledrag.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/tableselect.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/tablesort.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/tabs.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/textarea.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/ui-dialog.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/messages.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/node.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/messages.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/node.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/fixed-header.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/alert.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/block.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/better-exposed-filters.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/more-links.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/forms.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/item-list.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/inline-list.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/site-branding.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/tables.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/tabs.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/progress-bars.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/layout-switcher.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/menu.css?sndln6" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/components/views.css?sndln6" /> <link rel="stylesheet" media="all" href="//fonts.googleapis.com/css?family=Roboto+Condensed:400italic,700italic,400,300,700&subset=latin-ext,latin,greek" /> <link rel="stylesheet" media="all" href="//fonts.googleapis.com/css?family=Open+Sans:400,400i,600,600i,700,700i,800,800i&amp;subset=greek" /> <link rel="stylesheet" media="all" href="//fonts.googleapis.com/css?family=Source+Code+Pro&subset=latin,latin-ext" /> <link rel="stylesheet" media="all" href="//fonts.googleapis.com/css?family=PT+Serif:400,700,400italic,700italic&subset=latin,latin-ext" /> <link rel="stylesheet" media="all" href="/themes/custom/showcase_lite/css/theme/local-theme.css?sndln6" /> <link rel="stylesheet" href="https://use.typekit.net/cxb6mcr.css"> </head> <body class="page path-science-biofulcrum-viral-and-infectious-disease-research-program layout-no-sidebars wide hff-08 pff-06 sff-08 slff-08 headings-wide-spacing-enabled fixed-header-enabled"> <script>document.body.className += ' fade-out';</script>  <noscript> <iframe src="https://www.googletagmanager.com/ns.html?id=GTM-K92GBK5" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript>  <a href="#main-content" class="visually-hidden focusable"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <style> #topbar {background-image: url('/sites/default/files/2024-09/Dawn-Light-Repeat.png'); background-repeat: repeat-x; /* Repeat the image horizontally */ background-size: auto 100%; /* Ensure it stretches to fill the height */ width: 100vw; /* Full width of the viewport */ height: 80px; /* Set the desired height */ margin: 0; /* Flexbox to center the text */ display: flex; justify-content: center; /* Horizontal centering */ align-items: center; /* Vertical centering */ position: relative; } #topbar a { margin-left: 20px; } #topbar a:hover { background: linear-gradient(to right, #084b70, #032c42); /* Gradient background on hover */ color: rgba(255, 255, 255, 1); /* Change text color to white for contrast */ transition: background 0.3s ease, color 0.3s ease; /* Smooth transition for background and color */ border-color: rgba(0, 42, 64, 0.6); /* Keep border color transition */ } #topbar .button { display: inline-block; /* Or block, depending on your needs */ position: relative; /* Allow positioning adjustments */ transform: translateY(-2px); /* Raise the button by 2pixels */ } #close-topbar { font-size: 26px; color: #002A40; cursor: pointer; position: absolute; right: 2%; /* Move closer to the center */ top: 4px; z-index: 100; } #close-topbar:hover { color: #A87F72; /* Change background on hover */ } @media (max-width: 768px) { #topbar p { margin-top:1px !important; } #topbar a { margin-left: 0px; } #topbar a.button { display: block; /* Force the button onto a new line */ margin-top: 3px; /* Add space between text and button */ } #close-topbar { right: 5%; } } </style> <script> document.addEventListener("DOMContentLoaded", function() { // Check if the topbar should be hidden if (sessionStorage.getItem("hideTopBar")) { document.getElementById("topbar").style.display = "none"; } // Add event listener to the close button document.getElementById("close-topbar").addEventListener("click", function() { document.getElementById("topbar").style.display = "none"; sessionStorage.setItem("hideTopBar", "true"); }); }); </script> <div class="page-container"> <div id="topbar"><p style="padding-top:40px; font-weight:normal;">Gladstone NOW: The Campaign <a href="https://gladstonenow.org/" style="margin-top:0px!important;" class="button outline" rel="noopener" target="_blank">Join Us on the Journey</a><span id="close-topbar" style="cursor: pointer; margin-left: 15px;">✕</span></p></div>  <style> @supports not (mix-blend-mode: multiply) { #postdocs{background-image: url(/sites/default/files/background-images/ie/Training-postdocs.jpg)!important;} #grad-students{background-image: url(/sites/default/files/background-images/ie/People-grads.jpg)!important;} } _:-ms-lang(x), #postdocs{background-image: url(/sites/default/files/background-images/ie/Training-postdocs.jpg)!important;} _:-ms-lang(x), #grad-students{background-image: url(/sites/default/files/background-images/ie/People-grads.jpg)!important;} </style> <div class="big-giant-head"><div class="lil-head"> <div class="header-container"> <header role="banner" class="clearfix header region--dark-typography region--gray-background full-width two-columns"> <div class="container-fluid"> <div class="clearfix header__container"> <div class="search-below"> <div class="search-below-inner"> <form action="/google-search" method="GET"> <input id="search-input" class="search-input" placeholder="Search Keyword(s)" type="text" name="q" style="display:none"/> <input type="submit" value="Submit" style="display:none" /> </form> </div> </div> <div class="row"> <div class="col-md-4"> <div class="clearfix header__section header-first"> <div class="region region-header-first"> <div id="block-showcase-lite-branding" class="clearfix site-branding block block-system block-system-branding-block"> <div class="logo-and-site-name-wrapper clearfix"> <div class="logo"> <a href="/index.php/" title="Home" rel="home" class="site-branding__logo"> <img class="off-scrl" src="/sites/default/files/GladstoneLogoWh.png" alt="Home" /> <img class="on-scrl" src="/sites/default/files/GladstoneLogoNv.png" alt="Home" /> </a> </div> </div> </div> <div id="block-responsivemenumobileicon" class="responsive-menu-toggle-wrapper responsive-menu-toggle clearfix block block-responsive-menu block-responsive-menu-toggle"> <div class="content"> <a id="toggle-icon" class="toggle responsive-menu-toggle-icon" title="Menu" href="#off-canvas"> <span class="icon"></span><span class="label">Menu</span> </a> </div> </div> </div> </div> </div> <div class="col-md-8"> <div class="clearfix header__section header-second"> <div class="region region-header"> <div id="block-searchicon" class="clearfix block block-block-content block-block-content8acdf7a0-b4b7-49e8-9e8b-694518c63d40"> <div class="content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><img alt="search icon" class="pocus off-scrl" src="/themes/custom/showcase_lite/images/search-icon.png" /> <img alt="scroll search icon" class="pocus on-scrl" src="/themes/custom/showcase_lite/images/search-icon-nv.png" /></div> </div> </div> <div id="block-mainnavigation-2" class="clearfix block block-superfish block-superfishmain"> <div class="content"> <ul id="superfish-main" class="menu sf-menu sf-main sf-horizontal sf-style-none"> <li id="main-menu-link-contentec177805-cd19-4011-9d2a-730bffcb0770" class="sf-depth-1 menuparent"><a href="/about" class="sf-depth-1 menuparent">About</a><ul><li id="main-menu-link-contenta58c8004-dbdd-473d-9c7d-45b933a4bedf" class="sf-depth-2 sf-no-children"><a href="/people" class="sf-depth-2">People</a></li><li id="main-menu-link-contentc7d4f8d5-0eab-435c-98ce-5c1189992ac9" class="sf-depth-2 sf-no-children"><a href="/community-outreach" class="sf-depth-2">Outreach</a></li><li id="main-menu-link-content353c6936-53b7-4b6c-83d8-01460add4c93" class="sf-depth-2 sf-no-children"><a href="/our-core-values" class="sf-depth-2">Core Values</a></li><li id="main-menu-link-content5f286bab-4cfc-4de5-b061-388cd842ea72" class="sf-depth-2 sf-no-children"><a href="/diversity-equity-and-inclusion" class="sf-depth-2">Diversity, Equity, and Inclusion</a></li><li id="main-menu-link-contentebbe6ae0-c06b-4709-a6ab-ec04b12d6cae" class="sf-depth-2 sf-no-children"><a href="/about#finances" class="sf-depth-2">Finances</a></li><li id="main-menu-link-contenta51d07ea-dc8c-466a-830f-b776efe25b87" class="sf-depth-2 sf-no-children"><a href="/people/foundation-board" class="sf-depth-2">Gladstone Foundation</a></li><li id="main-menu-link-contentfdda1b91-039b-465e-9b46-fbd2f96d51a4" class="sf-depth-2 sf-no-children"><a href="/about/history" class="sf-depth-2">History</a></li><li id="main-menu-link-contente5031172-5afd-4fb1-af5c-af1d2b49b131" class="sf-depth-2 sf-no-children"><a href="/ogawa-yamanaka-stem-cell-prize" class="sf-depth-2">Ogawa-Yamanaka Stem Cell Prize</a></li><li id="main-menu-link-contentd60b06e4-a8a5-4a8e-b051-4291971584d6" class="sf-depth-2 sf-no-children"><a href="/about#contact" class="sf-depth-2">Contact</a></li></ul></li><li id="main-menu-link-content2fd8e091-0f6f-488c-8327-870a7667f9bb" class="active-trail sf-depth-1 menuparent"><a href="/science" class="sf-depth-1 menuparent">Science</a><ul><li id="main-menu-link-content9f48d697-aaff-4bc8-9d5d-0bb99cb9250f" class="sf-depth-2 sf-no-children"><a href="/science/institutes" class="sf-depth-2">Institutes</a></li><li id="main-menu-link-contenta99233e4-460c-4de2-879e-0b8681c72d32" class="sf-depth-2 sf-no-children"><a href="/science#centers" class="sf-depth-2">Centers</a></li><li id="main-menu-link-content6c639096-f891-4d1f-bdb3-36839a5e5f6e" class="sf-depth-2 sf-no-children"><a href="/science/cores" class="sf-depth-2">Core Facilities</a></li><li id="main-menu-link-content372262d3-f1a1-416a-91f7-6ed89b70f411" class="sf-depth-2 sf-no-children"><a href="/people/investigators" class="sf-depth-2">Investigators</a></li><li id="main-menu-link-content7d607630-2961-4c68-ae9f-f8824648a1fc" class="sf-depth-2 sf-no-children"><a href="/industry-partners" class="sf-depth-2">Industry Partners</a></li><li id="main-menu-link-content9f87c22d-7b75-4920-91b0-fe4e4d3648d2" class="active-trail sf-depth-2 sf-no-children"><a href="/science/programs" class="sf-depth-2">Programs</a></li></ul></li><li id="main-menu-link-contentc4e8c4f7-8d5c-430b-a475-a02e5e0230fa" class="sf-depth-1 menuparent"><a href="/training" class="sf-depth-1 menuparent">Training</a><ul><li id="main-menu-link-contentba2445f4-4738-44f3-92b4-154306766274" class="sf-depth-2 sf-no-children"><a href="/training/academic-affairs" class="sf-depth-2">Academic Affairs</a></li><li id="main-menu-link-contentd757d4e1-b20f-401a-bb06-cc6043f060e5" class="sf-depth-2 sf-no-children"><a href="/training/postdocs" class="sf-depth-2">Postdocs</a></li><li id="main-menu-link-content80d70947-0c90-44b3-837d-be54dbd481e4" class="sf-depth-2 sf-no-children"><a href="/training/graduate-students" class="sf-depth-2">Graduate Students</a></li><li id="main-menu-link-content1606964c-6173-446c-8e9a-e8c8287ae23b" class="sf-depth-2 sf-no-children"><a href="/cirm-scholars" class="sf-depth-2">CIRM Scholars Program</a></li><li id="main-menu-link-content6aa2371d-c1eb-4bcd-9a33-3487cff85166" class="sf-depth-2 sf-no-children"><a href="https://gladstone.org/embark" class="sf-depth-2 sf-external">Embark: Presidential Postdoctoral Program</a></li><li id="main-menu-link-content7bacc720-5f94-478b-a9a2-f03120667d4d" class="sf-depth-2 sf-no-children"><a href="/nomis-gladstone-fellowship-program" class="sf-depth-2">NOMIS–Gladstone Fellowship Program</a></li><li id="main-menu-link-content0bf33cd5-b878-4825-9439-dbdb7ec2e5c1" class="sf-depth-2 sf-no-children"><a href="/training/pumas-summer-internship-program" class="sf-depth-2">PUMAS Summer Internship Program</a></li></ul></li><li id="main-views-viewviewsnews-searchpage-1" class="sf-depth-1 menuparent"><a href="/news" class="sf-depth-1 menuparent">News</a><ul><li id="main-menu-link-content1cd935ac-2aef-4f8b-8139-51f3c5b37a24" class="sf-depth-2 sf-no-children"><a href="/media" class="sf-depth-2">For Media</a></li></ul></li><li id="main-menu-link-contentb916fc5c-0841-477f-b3ba-3c2810e6d392" class="sf-depth-1 sf-no-children"><a href="/events" class="sf-depth-1">Events</a></li><li id="main-menu-link-content0772936b-2355-40b4-b9af-5f9750726d1c" class="sf-depth-1 sf-no-children"><a href="/giving" class="sf-depth-1">Give</a></li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </header> </div> <div id="page-start" class="clearfix page-start"></div> <a name="main-content"></a> <div class="system-messages clearfix"> <div class="container"> <div class="row"> <div class="col-md-12"> <div class="region region-system-messages"> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-showcase-lite-page-title" class="clearfix block block-core block-page-title-block"> <div class="content"> <h1 class="title page-title"><span class="field field--name-title field--type-string field--label-hidden">BioFulcrum Viral and Infectious Disease Research Program</span> </h1> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="clearfix main-content region--dark-typography region--white-background region--no-separator"> <div class="landing-page-container" > <div class="clearfix main-content__container"> <div class="row"> <section> <div class="clearfix main-content__section" > <div class="region region-content"> <div id="block-showcase-lite-content" class="clearfix block block-system block-system-main-block"> <div class="content"> <article data-history-node-id="1097" class="node node--type-page node--view-mode-full clearfix"> <div class="node__container"> <div class="node__main-content clearfix"> <header class="node__header"> </header> <div class="container"> <nav role="navigation" aria-labelledby="block-biofulcrumtabs-menu" id="block-biofulcrumtabs" class="clearfix block block-menu navigation menu--biofulcrum-tabs"> <h2 class="visually-hidden" id="block-biofulcrumtabs-menu">Biofulcrum tabs</h2> <ul class="clearfix menu"> <li class="menu-item"> <a href="/science/biofulcrum" data-drupal-link-system-path="node/1096">Overview</a> </li> <li class="menu-item"> <a href="/science/biofulcrum-heart-failure-research-program" data-drupal-link-system-path="node/1098">Heart Failure</a> </li> <li class="menu-item menu-item--active-trail"> <a href="/science/biofulcrum-viral-and-infectious-disease-research-program" data-drupal-link-system-path="node/1097" class="is-active" aria-current="page">Viral and Infectious Disease</a> </li> </ul> </nav> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p class="large">So far, antiviral drugs have been developed to target specific proteins produced by pathogens. This “one bug, one drug” approach can be highly effective initially, but the stupendous rate of replication and mutation of viral genomes can quickly lead to resistance. The same is true for antimicrobial drugs targeting bacteria, where we battle increased resistance to available antibiotics.</p> <p>Launched in 2017, this second <a href="/science/biofulcrum">BioFulcrum research program</a> takes an entirely different approach by identifying human host proteins. These proteins interact physically with viral and bacterial gene products in ways that are essential for microbial pathogenesis, and thus may serve as targets for the development of new classes of antiviral/bacterial therapeutics.</p> <p>The program builds upon solid prior research that used leading-edge technologies to define host-pathogen protein interactomes. The research will also include further experiments to complete an atlas for additional pathogens, and will identify valid drug targets from among thousands of candidate host proteins. It will focus on targets that are important for pathogenesis of multiple pathogens (“one drug stops several bugs”), that can be drugged without toxic effects on the host, and that remain essential for pathogenesis despite pathogen evolution.</p> <div class="pullquote"> <h2>Progam Objectives</h2> <ul> <li>Create a comprehensive map of the genetic and protein networks underlying infectious diseases</li> <li>Uncover host molecular pathways commonly hijacked by pathogens to reveal basic biological mechanisms and novel therapeutic targets</li> <li>Develop new technologies that use a single small molecule or drug to target multiple pathogens</li> </ul> </div> </div> </div> </div> </div> </article> </div> </div> <div id="block-scientificpartnersvirology" class="clearfix block block-block-content block-block-contentadc516df-d00d-400e-9bcb-4feff932c5f3"> <div class="content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="container"> <h2>Scientific Partners</h2> <br /> <div class="col-sm-4"> <ul> <li><strong>Jeff Cox, PhD</strong><br/>UC Berkeley</li> <li><strong>Jennifer Doudna, PhD</strong><br/>Gladstone Institutes<br/>UC Berkeley<br/>UC San Francisco</li> </ul> </div> <div class="col-sm-4"> <ul> <li><strong>Nevan Krogan, PhD</strong><br/>Gladstone Institutes<br/>UC San Francisco</li> <li><strong>Alex Marson, MD, PhD</strong><br/>Gladstone Institutes<br/>UC San Francisco</li> </ul> </div> <div class="col-sm-4"> <ul> <li><strong>Melanie Ott, MD, PhD</strong><br/>Gladstone Institutes</li> <li><strong>Katie Pollard, PhD</strong><br/>Gladstone Institutes</li> </ul> </div> </div> </div> </div> </div> <div id="block-allnews" class="clearfix block block-block-content block-block-content54b395c1-79cb-4273-bb84-8c637a97d3c7"> <div id="related-news" class="container"> <h2>Recent News</h2> <div id="news-carousel" class="owl-carousel"> </div> </div> <script src="/core/assets/vendor/jquery/jquery.min.js?v=3.2.1:2:28017"></script> <script src="/libraries/owl-carousel2/owl.carousel.js"></script> <script> jQuery(document).ready(function() { jQuery.ajax({ type: "GET", url: "https://gladstone.org/all-news", dataType: "xml", success: parseXml }); }); function parseXml(xml) { jQuery(xml).find("item").each(function() { thepic = jQuery(this).find("Image").text(); link = jQuery(this).find("Link").text(); summary = jQuery(this).find("Summary").text(); alt = jQuery(this).find("Alt").text(); title = jQuery(this).find("Title").text(); date = jQuery(this).find("Date").text(); jQuery("#news-carousel").append("<a href='"+link+"' title='Read more' target='_self'><div class='item'><img alt='"+alt+"' class='owl-lazy' data-src='"+thepic+"' src='"+thepic+"' style='opacity: 1;'><div class='blowpic'>"+title+"<br><div class='summy'>"+summary+"</div><div class='authored'>"+date+"</div></div></div></a>"); }); var owlnews = $('#news-carousel'); owlnews.owlCarousel({ margin: 10, lazyLoad:true, lazyLoadEager: 1, loop: true, dots: false, responsive: { 0: { items: 1 }, 600: { items: 2 }, 1000: { items: 3, nav: true } } }) // disable scroll owlnews.on('drag.owl.carousel', function(event) { document.ontouchmove = function (e) { e.preventDefault() } }) // enable scroll owlnews.on('dragged.owl.carousel', function(event) { document.ontouchmove = function (e) { return true } }) } </script> </div> </div> </div> </section> </div> </div> </div> </div> <footer class="clearfix footer region--light-typography region--dark-background region--no-separator "> <div class="container"> <div class="clearfix footer__container"> <div class="row"> <div class="col-sm-6"> <div class="clearfix footer__section footer-first" > <div class="region region-footer-first"> <div id="block-footerlogoandtext" class="clearfix block block-block-content block-block-content070d0444-f1db-41b9-b0e5-c612e818de00"> <div class="content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><img alt="Gladstone Logo" data-entity-type="file" data-entity-uuid="d46b018a-8f64-44cc-a976-32422aa080da" src="/sites/default/files/inline-images/GladstoneLogoBlu.png" width="200px" /></p> <p class="small">Gladstone Institutes is an independent state-of-the-art biomedical research institution that empowers its world-class scientists to find new pathways to cures.</p> <p><a title="Gladstone Facebook page" href="https://www.facebook.com/gladstoneinstitutes" target="_blank"><i class="fa fa-facebook" aria-hidden="false"></i></a> <a title="Gladstone Twitter page" href="https://twitter.com/GladstoneInst" target="_blank"><i class="fa-brands fa-x-twitter" aria-hidden="false"></i></a> <a title="Gladstone Youtube channel" href="https://www.youtube.com/user/GladstoneScience" target="_blank"><i class="fa fa-youtube-play" aria-hidden="false"></i></a> <a title="Gladstone on Instagram" href="https://www.instagram.com/gladstoneinstitutes/" target="_blank"><i class="fa fa-instagram" aria-hidden="false"></i></a> <a title="Gladstone LinkedIn company profile" href="https://www.linkedin.com/company/gladstoneinstitutes/" target="_blank"><i class="fa fa-linkedin" aria-hidden="false"></i></a></p> </div> </div> </div> </div> </div> </div> <div class="col-sm-6"> <div class="clearfix footer__section footer-second" > <div class="region region-footer-second"> <div id="block-mailchimpsignup" class="clearfix block block-block-content block-block-contentca1523b3-883f-4a8f-82fb-6004e5955761"> <div class="content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><h5>Stay up to date with us</h5> <p class="small">Subscribe to our newsletter  to receive monthly updates on the innovative discoveries, distinguishing awards, and noteworthy events taking place at Gladstone Institutes.</p>  <div id="mc_embed_signup"> <form action="https://gladstoneinstitutes.us10.list-manage.com/subscribe/post?u=1a62a392ffda799ebdf0313d3&id=f25fc65fc1" method="post" id="mc-embedded-subscribe-form" name="mc-embedded-subscribe-form" class="validate" target="_blank" novalidate> <div id="mc_embed_signup_scroll"> <div class="mc-field-group" > <input type="email" value="" name="EMAIL" class="required email" id="mce-EMAIL" placeholder="Email Address"><label for="mce-EMAIL" class="form-label-hide">Email Address</label> </div> <div id="mce-responses" class="clear"> <div class="response" id="mce-error-response" style="display:none"></div> <div class="response" id="mce-success-response" style="display:none"></div> </div>  <div style="position: absolute; left: -5000px;" aria-hidden="true"><input type="text" id="whatsamattau" name="b_1a62a392ffda799ebdf0313d3_f25fc65fc1" tabindex="-1" value=""><label for="whatsamattau" class="form-label-hide">Comments</label></div> <div class="clear"><input type="submit" value="Subscribe" name="subscribe" id="mc-embedded-subscribe"></div> </div> </form> </div> </div> </div> </div> </div> </div> </div> <div class="clearfix visible-xs-block"></div> <div class="clearfix visible-xs-block visible-xs-block"></div> </div> </div> </div> </footer> <div class="clearfix footer-bottom region--light-typography region--dark-background region--no-separator "> <div class="container"> <div class="clearfix footer-bottom__container"> <div class="row"> <div class="col-md-12"> <div class="clearfix footer-bottom__section"> <div class="region region-footer-bottom"> <div id="block-footeraddressandcopyrightetc" class="clearfix block block-block-content block-block-content35b59adf-34dd-4cb5-912f-296911f75197"> <div class="content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><hr noshade /> <p><b><span>1650 Owens Street, San Francisco, CA 94158</span> <span class="safety"><a href="/crisis-response-and-building-safety">Crisis Response and Building Safety</a></span> 415.734.2000</b><br> <span>© 2024 Gladstone Institutes</span> <span>All Rights Reserved</span> <span><a href="https://gladstone.org/terms-conditions">Terms and Conditions</a></span> <a href="https://gladstone.org/conflict-of-interest">Conflict of Interest</a><br> Registered 501(c)(3). EIN: 23-7203666</p> <p id="footerlinks"><a href="/careers" class="footerlink">Careers</a> <a href="/media" class="footerlink">For Media</a> <a href="/about#contact" class="footerlink">Contact</a></p> <style> .path-science-histology-and-light-microscopy-core #3040 {display:none !important} .path-events-2024-ogawa-yamanaka-stem-cell-prize-reception #valet-p {margin-top:10px} .path-people-lisa-elia #related-news{display:none} .path-people-john-peck .relatedlinks {display:none} .news h2.lite, .event h2.lite {color:#002A40 !important} #second-blurb {display:none} #3040 {visibility:hidden} .safety a {font-weight:800} .investigator #contact .to-hide {padding-bottom:22px} .path-training #nomis .display {margin-bottom: 20px} @media (min-width: 1200px) { .path-celebrate25 #block-showcase-lite-page-title {width:88%; height:auto;} .path-forms-2023-ogawa-yamanaka-prize-media-registration .block-page-title-block {width:80%} } @media (max-width: 1199px) { .path-forms-2023-ogawa-yamanaka-prize-media-registration .block-page-title-block {width:100%} .path-celebrate25 #block-showcase-lite-page-title {width:112%} } @media (max-width: 991px) { .path-celebrate25 #block-showcase-lite-page-title {width:99%} .path-forms-2023-ogawa-yamanaka-prize-media-registration .block-page-title-block {width:93%} } @media (max-width: 658px) { .path-celebrate25 #block-showcase-lite-page-title {width:100%} } .path-celebrate25 #intro table td, .path-celebrate25 table th {text-align:left} .path-celebrate25 #intro table li {font-size: 18px; font-weight:400} .path-people-taha-taha #related-news {display:none} #block-mediatabs.moby ul li a {padding: 6px;font-size: 12px;line-height: 15px;color: #002A40;font-weight: 600;letter-spacing: 1px;border: 1px solid #F5F5F5;text-align: center;margin: 3px 0;} #block-nomistabs {margin-top: -21px;margin-bottom: 60px;} #block-diversitytabs .menu-item--active-trail a, #block-peopletabs .menu-item--active-trail a, #block-ogawatabs .menu-item--active-trail a, #block-trainingtabs .menu-item--active-trail a, #block-biofulcrumtabs .menu-item--active-trail a, #block-embarktags .menu-item--active-trail a, #block-pumastabs-2 .menu-item--active-trail a, #block-mediatabs .menu-item--active-trail a, #block-donatetabs .menu-item--active-trail a, #block-institutetabs .menu-item--active-trail a, #block-nomistabs .menu-item--active-trail a {border-width: 0;border-top-width: 8px;border-style: solid;border-image: linear-gradient(to right,#CC29A4,#F76912) 1 0;text-decoration: none;font-weight: bold;} #block-diversitytabs.moby .menu-item--active-trail a, #block-peopletabs.moby .menu-item--active-trail a, #block-ogawatabs.moby .menu-item--active-trail a, #block-trainingtabs.moby .menu-item--active-trail a, #block-biofulcrumtabs.moby .menu-item--active-trail a, #block-embarktags.moby .menu-item--active-trail a, #block-pumastabs-2.moby .menu-item--active-trail a, #block-mediatabs.moby .menu-item--active-trail a, #block-donatetabs.moby .menu-item--active-trail a, #block-institutetabs.moby .menu-item--active-trail a, #block-nomistabs.moby .menu-item--active-trail a {border-width: 1px;border-image: none;background-image: linear-gradient(to right,#CC29A4,#F76912);text-decoration: none;color: white;} .path-events-centering-health-justice-and-trans-well-being .col-sm-3 img {margin-left:-15px; margin-top:8px} @media (max-width: 767px) { .event #intro .col-sm-3, .event #intro .col-sm-9,.event #additional .col-sm-3, .event #additional .col-sm-9{padding-left:0; padding-bottom:20px} .event .subsec.sscontacts {margin-bottom:-27px} .path-events-centering-health-justice-and-trans-well-being .col-sm-9 {margin-left:-15px} } .path-news-heres-what-6-scientists-have-say-about-alzheimers-disease-research #block-showcase-lite-content{padding-top:0} .path-news-heres-what-6-scientists-have-say-about-alzheimers-disease-research .node__header{padding:0} .path-home #covidlink{display:none} .path-events-2022-ogawa-yamanaka-stem-cell-prize-ceremony #related-news{display:none} .path-events-2022-ogawa-yamanaka-stem-cell-prize-ceremony #block-ogawanews #related-news {display:block !important} .path-events-2022-ogawa-yamanaka-stem-cell-prize-ceremony #block-ogawanews {margin-top:-26px} .nonlink{text-decoration:none !important} img{height:auto} .path-people-catherine-tcheandjieu-gueliatcha .system-messages {margin-top:138px} .path-people-barbara-engelhardt .owl-nav,.path-people-karin-pelka .owl-nav,.path-people-vijay-ramani .owl-nav,.path-people-catherine-tcheandjieu-gueliatcha .owl-nav,.path-people-ryan-corces .owl-nav, .path-people-christina-theodoris .owl-nav,.path-people-michael-alexanian .owl-nav, .path-people-swetansu-hota .owl-nav, .path-people-julia-kaye .owl-nav{display:none} .path-people-barbara-engelhardt .cloned,.path-people-karin-pelka .cloned,.path-people-vijay-ramani .cloned, .path-people-catherine-tcheandjieu-gueliatcha .cloned,.path-people-ryan-corces .cloned,.path-people-christina-theodoris .cloned,.path-people-michael-alexanian .cloned, .path-people-swetansu-hota .cloned, .path-people-julia-kaye .cloned{visibility:hidden} .path-people-melanie-ott .to-hide a {display:none;} .path-people-melanie-ott a.inv-phone {display:block !important; margin-top:-37px} .investigator .labbies{display:none} .event .col-sm-3 img {max-width:100%} .owl-carousel,.owl-nav,.owl-stage-outer{outline:none} .path-events-hanukkah-celebration #event-partners {padding: 58px 0; background-image: linear-gradient(to right,#002A40,#00D4E6);} .path-ogawa-yamanaka-stem-cell-prize .big-giant-head, .path-ogawa-yamanaka-stem-cell-prize-criteria .big-giant-head{background-position:center !important} .path-ogawa-yamanaka-stem-cell-prize #second-blurb p:nth-of-type(2){display:none} #datalist .button{color:#002A40} .path-science-genomic-immunology-institute #dvision {display: block;} .path-science-genomic-immunology-institute #dvision p.small{padding:0 0 8px 0} .path-science-genomic-immunology-institute #dvision .container {margin-top:-7px} .path-science-genomic-immunology-institute #dvision .col-sm-4{padding-left:0} .event #additional th,#additional td{text-align:left} .event #additional th{background:#00D4E6} .event #additional {margin-bottom:54px;margin-top:-50px} .event .pullquote .col-sm-6{padding-left:0} .vilcek-partners{margin-top:34px} .vilcek-partners img{width:100%} .subsecdate div{margin-bottom:14px} .schmoo .labsite .button{font-size:14px} #block-views-block-user-admin-people-scientist h1.page-title{text-transform:uppercase} .path-people-christof-fellmann .pubitem div {font-size: 24px; margin-bottom:24px} #datalist .pubitem{font-size:24px} .path-news-highlights-gladstones-scientific-advisory-board-meeting .field--name-field-story div,.path-news-celebrating-2022-pumas-interns .field--name-field-story div {width:100% !important; height:750px !important} .path-news-highlights-gladstones-scientific-advisory-board-meeting .field--name-field-images,.path-news-celebrating-2022-pumas-interns .field--name-field-images{display:none} .path-people-ansuman-satpathy .sudonav {display:none} .path-form-ogawa-yamanaka-stem-cell-prize-nomination-2023 .big-giant-head {background-image: url(/sites/default/files/background-images/Web-Banner-2022-form.jpg);background-size: cover;background-repeat: no-repeat} .path-science-bioinformatics-core #publications {margin-top:-24px} @media (max-width: 1200px) { .path-news-highlights-gladstones-scientific-advisory-board-meeting .field--name-field-story div,.path-news-celebrating-2022-pumas-interns .field--name-field-story div { height:700px !important} } @media (max-width: 991px) { .path-news-highlights-gladstones-scientific-advisory-board-meeting .field--name-field-story div,.path-news-celebrating-2022-pumas-interns .field--name-field-story div { height:600px !important} .ssaudience,.sshashtag{font-size:20px} } @media (max-width: 670px) { .path-news-highlights-gladstones-scientific-advisory-board-meeting .field--name-field-story div,.path-news-celebrating-2022-pumas-interns .field--name-field-story div { height:450px !important} } @media (max-width: 450px) { .path-news-highlights-gladstones-scientific-advisory-board-meeting .field--name-field-story div,.path-news-celebrating-2022-pumas-interns .field--name-field-story div { height:300px !important} } @media (min-width: 768px) { .event #intro .col-sm-3, .event #additional .col-sm-3 {padding-left:0 !important} .event #intro .col-sm-3 img, .event #additional .col-sm-3 img{padding-top:8px} .event .subsec.sscontacts {margin-bottom:-18px} } .view-display-id-confocal .views-row:nth-child(4) {visibility:hidden !important} .view-display-id-histology_widefield .views-row:nth-child(4), .view-display-id-histology_widefield .views-row:nth-child(5), .view-display-id-histology_widefield .views-row:nth-child(6){visibility:hidden !important} </style></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <script> if ($(window).width() < 950) { $('#sabimg').removeClass('parallax_bg'); } </script> </div> <div class="off-canvas-wrapper"><div id="off-canvas"> <ul> <li class="menu-item--ec177805-cd19-4011-9d2a-730bffcb0770 menu-name--main"> <a href="/about" data-drupal-link-system-path="node/2518">About</a> <ul> <li class="menu-item--a58c8004-dbdd-473d-9c7d-45b933a4bedf menu-name--main"> <a href="/people" data-drupal-link-system-path="node/29">People</a> <ul> <li class="menu-item--_66da21c-3e1d-4f62-bc37-4df0658a194e menu-name--main"> <a href="/people/investigators" data-drupal-link-system-path="people/investigators">Investigators</a> </li> <li class="menu-item--_3dae56e-59f8-4793-9742-d7bf30652239 menu-name--main"> <a href="/people/leadership" data-drupal-link-system-path="people/leadership">Leadership</a> </li> <li class="menu-item--a2c0d309-5cc7-4a19-93af-4c2c573f44c5 menu-name--main"> <a href="/people/trustees" data-drupal-link-system-path="node/3057">Trustees</a> </li> <li class="menu-item--fc5284a2-f8d3-47ee-bcc9-47c458cf95ba menu-name--main"> <a href="/people/foundation-board" data-drupal-link-system-path="node/1066">Gladstone Foundation</a> </li> </ul> </li> <li class="menu-item--c7d4f8d5-0eab-435c-98ce-5c1189992ac9 menu-name--main"> <a href="/community-outreach" data-drupal-link-system-path="node/1094">Outreach</a> </li> <li class="menu-item--_53c6936-53b7-4b6c-83d8-01460add4c93 menu-name--main"> <a href="/our-core-values" data-drupal-link-system-path="node/3277">Core Values</a> </li> <li class="menu-item--_f286bab-4cfc-4de5-b061-388cd842ea72 menu-name--main"> <a href="/diversity-equity-and-inclusion" data-drupal-link-system-path="node/3276">Diversity, Equity, and Inclusion</a> </li> <li class="menu-item--ebbe6ae0-c06b-4709-a6ab-ec04b12d6cae menu-name--main"> <a href="/about#finances" data-drupal-link-system-path="node/2518">Finances</a> </li> <li class="menu-item--a51d07ea-dc8c-466a-830f-b776efe25b87 menu-name--main"> <a href="/people/foundation-board" data-drupal-link-system-path="node/1066">Gladstone Foundation</a> </li> <li class="menu-item--fdda1b91-039b-465e-9b46-fbd2f96d51a4 menu-name--main"> <a href="/about/history" data-drupal-link-system-path="node/1065">History</a> </li> <li class="menu-item--e5031172-5afd-4fb1-af5c-af1d2b49b131 menu-name--main"> <a href="/ogawa-yamanaka-stem-cell-prize" data-drupal-link-system-path="node/1601">Ogawa-Yamanaka Stem Cell Prize</a> </li> <li class="menu-item--d60b06e4-a8a5-4a8e-b051-4291971584d6 menu-name--main"> <a href="/about#contact" data-drupal-link-system-path="node/2518">Contact</a> </li> </ul> </li> <li class="menu-item--_fd8e091-0f6f-488c-8327-870a7667f9bb menu-name--main menu-item--active-trail"> <a href="/science" data-drupal-link-system-path="node/2514">Science</a> <ul> <li class="menu-item--_f48d697-aaff-4bc8-9d5d-0bb99cb9250f menu-name--main"> <a href="/science/institutes" data-drupal-link-system-path="node/2535">Institutes</a> <ul> <li class="menu-item--_525724c-b24e-48a3-8ef6-b8974ac54ad8 menu-name--main"> <a href="/science/cardiovascular-disease-institute" data-drupal-link-system-path="node/2510">Cardiovascular Disease Institute</a> </li> <li class="menu-item--_04936dc-1ef2-4bb1-9e32-4a56a277e4b0 menu-name--main"> <a href="/science/data-science-and-biotechnology-institute" data-drupal-link-system-path="node/2513">Data Science and Biotechnology Institute</a> </li> <li class="menu-item--_5109bba-9b47-4bd4-99a5-11362904b343 menu-name--main"> <a href="/science/genomic-immunology-institute" data-drupal-link-system-path="node/3081">Genomic Immunology Institute</a> </li> <li class="menu-item--bea93446-0f27-4042-a0af-30613390a301 menu-name--main"> <a href="/science/neurological-disease-institute" data-drupal-link-system-path="node/2512">Neurological Disease Institute</a> </li> <li class="menu-item--_cfc4794-e62c-40a8-91d0-09114051a52f menu-name--main"> <a href="/science/virology-institute" data-drupal-link-system-path="node/2511">Virology Institute</a> </li> </ul> </li> <li class="menu-item--a99233e4-460c-4de2-879e-0b8681c72d32 menu-name--main"> <a href="/science#centers" data-drupal-link-system-path="node/2514">Centers</a> </li> <li class="menu-item--_c639096-f891-4d1f-bdb3-36839a5e5f6e menu-name--main"> <a href="/science/cores" data-drupal-link-system-path="node/2515">Core Facilities</a> <ul> <li class="menu-item--c421a1c7-4eb1-4fe7-b6c2-4a6db85b43a9 menu-name--main"> <a href="/science/assay-development-and-drug-discovery-core" data-drupal-link-system-path="node/3279">Assay Development and Drug Discovery Core</a> </li> <li class="menu-item--d02302f5-3d39-4ed5-9ebf-d6838c46228a menu-name--main"> <a href="/science/behavioral-core" data-drupal-link-system-path="node/3267">Behavioral core</a> </li> <li class="menu-item--_65ea1cd-f913-4854-b122-f8565166c03a menu-name--main"> <a href="/science/bioinformatics-core" data-drupal-link-system-path="node/3268">Bioinformatics Core</a> </li> <li class="menu-item--f5b785c5-1195-4293-bbbe-9182a89cdd12 menu-name--main"> <a href="/science/flow-cytometry-core" data-drupal-link-system-path="node/3270">Flow Cytometry Core</a> </li> <li class="menu-item--_0287e05-2beb-46e3-899a-7e9610d9d713 menu-name--main"> <a href="/science/genomics-core" data-drupal-link-system-path="node/3271">Genomics Core</a> </li> <li class="menu-item--_3cd92df-90f8-4ea6-9ce8-c66919cc47cc menu-name--main"> <a href="/science/histology-and-light-microscopy-core" data-drupal-link-system-path="node/3269">Histology and Light Microscopy Core</a> </li> <li class="menu-item--_e89022b-0ae7-45d0-b775-67e2103df680 menu-name--main"> <a href="https://labs.gladstone.org/mass_spectrometry">Mass Spectrometry Facility</a> </li> <li class="menu-item--_bf032e3-ab9d-4f74-b03c-3384cc7450fc menu-name--main"> <a href="/science/stem-cell-core" data-drupal-link-system-path="node/3273">Stem Cell Core</a> </li> <li class="menu-item--_4d75575-fd61-4e57-a9eb-250e2eca62a9 menu-name--main"> <a href="/science/transgenic-gene-targeting-core" data-drupal-link-system-path="node/3274">Transgenic Gene Targeting Core</a> </li> </ul> </li> <li class="menu-item--_72262d3-f1a1-416a-91f7-6ed89b70f411 menu-name--main"> <a href="/people/investigators" data-drupal-link-system-path="people/investigators">Investigators</a> </li> <li class="menu-item--_d607630-2961-4c68-ae9f-f8824648a1fc menu-name--main"> <a href="/industry-partners" data-drupal-link-system-path="node/1596">Industry Partners</a> <ul> <li class="menu-item--_68c3c4f-a1c6-4a76-8faf-eadceaeff105 menu-name--main"> <a href="/science/cure-network-ventures" data-drupal-link-system-path="node/2081">Cure Network Ventures</a> </li> <li class="menu-item--_ffb2c07-31a2-46af-8291-5c51aa650f22 menu-name--main"> <a href="/science/licensing/old" data-drupal-link-system-path="node/2080">Licensing</a> </li> </ul> </li> <li class="menu-item--_f87c22d-7b75-4920-91b0-fe4e4d3648d2 menu-name--main menu-item--active-trail"> <a href="/science/programs" data-drupal-link-system-path="node/7870">Programs</a> <ul> <li class="menu-item--c22b65a3-c9d1-4665-a259-0c3fc6136e28 menu-name--main menu-item--active-trail"> <a href="/science/biofulcrum" data-drupal-link-system-path="node/1096">BioFulcrum</a> <ul> <li class="menu-item--d76a90e0-749a-40cc-885c-8020679b3432 menu-name--main"> <a href="/science/biofulcrum-heart-failure-research-program" data-drupal-link-system-path="node/1098">Heart Failure Research Program</a> </li> <li class="menu-item--dca3d1cc-bd03-46f4-8bd7-8c444e9792cd menu-name--main menu-item--active-trail"> <a href="/science/biofulcrum-viral-and-infectious-disease-research-program" data-drupal-link-system-path="node/1097" class="is-active" aria-current="page">Viral and Infectious Disease Research Program</a> </li> </ul> </li> <li class="menu-item--_3db7004-9d99-4ee8-8754-9bef04ea0606 menu-name--main"> <a href="/science/hope-collaboratory" data-drupal-link-system-path="node/7869">Hope Collaboratory</a> </li> </ul> </li> </ul> </li> <li class="menu-item--c4e8c4f7-8d5c-430b-a475-a02e5e0230fa menu-name--main"> <a href="/training" data-drupal-link-system-path="node/1594">Training</a> <ul> <li class="menu-item--ba2445f4-4738-44f3-92b4-154306766274 menu-name--main"> <a href="/training/academic-affairs" data-drupal-link-system-path="node/2516">Academic Affairs</a> <ul> <li class="menu-item--ca6f017b-b12a-4c5f-b458-80b7544707c5 menu-name--main"> <a href="/living-in-san-francisco" data-drupal-link-system-path="node/1079">Living and Working in San Francisco</a> </li> </ul> </li> <li class="menu-item--d757d4e1-b20f-401a-bb06-cc6043f060e5 menu-name--main"> <a href="/training/postdocs" data-drupal-link-system-path="node/7604">Postdocs</a> </li> <li class="menu-item--_0d70947-0c90-44b3-837d-be54dbd481e4 menu-name--main"> <a href="/training/graduate-students" data-drupal-link-system-path="node/1081">Graduate Students</a> </li> <li class="menu-item--_606964c-6173-446c-8e9a-e8c8287ae23b menu-name--main"> <a href="/cirm-scholars" data-drupal-link-system-path="node/8481">CIRM Scholars Program</a> </li> <li class="menu-item--_aa2371d-c1eb-4bcd-9a33-3487cff85166 menu-name--main"> <a href="https://gladstone.org/embark">Embark: Presidential Postdoctoral Program</a> <ul> <li class="menu-item--a9681b53-5bf9-4121-83a4-55dc4b3ded2b menu-name--main"> <a href="/form/embark" data-drupal-link-system-path="webform/gladstone_presidential_postdocto">Apply</a> </li> </ul> </li> <li class="menu-item--_bacc720-5f94-478b-a9a2-f03120667d4d menu-name--main"> <a href="/nomis-gladstone-fellowship-program" data-drupal-link-system-path="node/8241">NOMIS–Gladstone Fellowship Program</a> </li> <li class="menu-item--_bf33cd5-b878-4825-9439-dbdb7ec2e5c1 menu-name--main"> <a href="/training/pumas-summer-internship-program" data-drupal-link-system-path="node/1605">PUMAS Summer Internship Program</a> <ul> <li class="menu-item--_efb5f93-215f-4d2a-945a-bab43e81dfd4 menu-name--main"> <a href="/pumas-application-instructions" data-drupal-link-system-path="node/3527">PUMAS Application Instructions</a> </li> </ul> </li> </ul> </li> <li class="menu-item--viewsnews-searchpage-1 menu-name--main"> <a href="/news" data-drupal-link-system-path="news">News</a> <ul> <li class="menu-item--_cd935ac-2aef-4f8b-8139-51f3c5b37a24 menu-name--main"> <a href="/media" data-drupal-link-system-path="node/1070">For Media</a> </li> </ul> </li> <li class="menu-item--b916fc5c-0841-477f-b3ba-3c2810e6d392 menu-name--main"> <a href="/events" data-drupal-link-system-path="events">Events</a> </li> <li class="menu-item--_772936b-2355-40b4-b9af-5f9750726d1c menu-name--main"> <a href="/giving" data-drupal-link-system-path="node/1083">Give</a> </li> </ul> </div></div> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/1097","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJyFk-GOGyEMhF8IQn9VfRtkwLvrBjCy4S7p05eLcqkObXW_1jPfIKHBC7_h5jNDQnHwb770QzgEFBMzqN5dAMXPuaAq7KifunKajAXnJAUy_UGDt56pXl2S0SBfntJs1N8oqXt-X5oqdbNn2o8e-LZIT3UeRrcapswcC9QdvULJbtEXSNMxHLahETp6LEDZJdxg5G4EtXFVekNfsA636EsQhGtjqt9HI9eN9m9j2u_z3rvRg9_jLNRn6jirjdddeNRkqcxebcgcr2uIuWsXaDamurDImcXuAvcFbHTDZA_8eNEVce3wjsoFT4haSvbHz_-SX6ekdasotJ1C5SER41yVJrwk9swBsj2vZ5bxZKgHYteFv7bxq_1Yyq-WllniYTUK52yUSsvoG7fR_KNydSee0dFQNtLDvaYzzz8mHeH0xAdtrNSJ6ynvPOIxb4Y4-V07lscv9xcFRG7k","theme":"showcase_lite","theme_token":null},"ajaxTrustedUrl":[],"responsive_menu":{"position":"left","theme":"theme-dark","pagedim":"pagedim","modifyViewport":true,"use_bootstrap":false,"breakpoint":"all and (min-width: 992px)","drag":false},"ajaxLoader":{"markup":"\u003Cdiv class=\u0022ajax-throbber sk-flow\u0022\u003E\n \u003Cdiv class=\u0022sk-flow-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-flow-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-flow-dot\u0022\u003E\u003C\/div\u003E\n \u003C\/div\u003E","hideAjaxMessage":false,"alwaysFullscreen":false,"throbberPosition":"body"},"fitvids":{"selectors":".node\r,.breaklft","custom_vendors":"","ignore_selectors":".twovids\r,.twovids-mobile"},"glightbox":{"openEffect":"zoom","closeEffect":"zoom","slideEffect":"slide","closeOnOutsideClick":true,"width":"98%","height":"98%","videosWidth":"","moreText":"","descPosition":"bottom","loop":false,"zoomable":true,"draggable":true,"preload":true,"autoplayVideos":false,"autofocusVideos":false},"simple_popup_blocks":{"settings":[]},"data":{"extlink":{"extTarget":false,"extTargetAppendNewWindowLabel":"(opens in a new window)","extTargetNoOverride":false,"extNofollow":false,"extNoreferrer":false,"extFollowNoOverride":false,"extClass":"0","extLabel":"(link is external)","extImgClass":false,"extSubdomains":true,"extExclude":"","extInclude":"","extCssExclude":".header-author","extCssInclude":"","extCssExplicit":"","extAlert":false,"extAlertText":"This link will take you to an external web site. We are not responsible for their content.","extHideIcons":false,"mailtoClass":"0","telClass":"","mailtoLabel":"(link sends email)","telLabel":"(link is a phone number)","extUseFontAwesome":false,"extIconPlacement":"append","extFaLinkClasses":"fa fa-external-link","extFaMailtoClasses":"fa fa-envelope-o","extAdditionalLinkClasses":"","extAdditionalMailtoClasses":"","extAdditionalTelClasses":"","extFaTelClasses":"fa fa-phone","whitelistedDomains":null,"extExcludeNoreferrer":""}},"superfish":{"superfish-main":{"id":"superfish-main","sf":{"animation":{"opacity":"show","height":"show"},"speed":"fast","autoArrows":false,"dropShadows":false,"disableHI":true},"plugins":{"touchscreen":{"behaviour":0,"mode":"window_width","breakpoint":1200},"supposition":true,"supersubs":{"minWidth":14,"maxWidth":20}}}},"user":{"uid":0,"permissionsHash":"00ee4b4e45ee0887fca65f62a578eaa0f7bd8270bfbecd3b33e3e3d874f97f13"}}</script> <script src="/modules/contrib/jquery_once/lib/jquery_3.7.1_jquery.min.js?v=3.7.1"></script> <script src="/core/assets/vendor/once/once.min.js?v=1.0.1"></script> <script src="/modules/contrib/jquery_once/lib/jquery-once-2.2.3/jquery.once.min.js?v=2.2.3"></script> <script src="/core/misc/drupalSettingsLoader.js?v=10.3.9"></script> <script src="/core/misc/drupal.js?v=10.3.9"></script> <script src="/core/misc/drupal.init.js?v=10.3.9"></script> <script src="/core/assets/vendor/tabbable/index.umd.min.js?v=6.2.0"></script> <script src="/libraries/mmenu/dist/mmenu.js?v=10.3.9"></script> <script src="/modules/contrib/responsive_menu/js/responsive_menu.config.js?v=10.3.9"></script> <script src="/core/misc/progress.js?v=10.3.9"></script> <script src="/core/assets/vendor/loadjs/loadjs.min.js?v=4.3.0"></script> <script src="/core/misc/debounce.js?v=10.3.9"></script> <script src="/core/misc/announce.js?v=10.3.9"></script> <script src="/core/misc/message.js?v=10.3.9"></script> <script src="/core/misc/ajax.js?v=10.3.9"></script> <script src="/themes/contrib/stable/js/ajax.js?v=10.3.9"></script> <script src="/modules/contrib/ajax_loader/js/ajax-throbber.js?v=1.x"></script> <script src="/libraries/fitvids/jquery.fitvids.js?v=10.3.9"></script> <script src="/modules/contrib/fitvids/js/init-fitvids.js?v=10.3.9"></script> <script src="/modules/custom/glightbox/js/glightbox.js?v=10.3.9"></script> <script src="/libraries/glightbox/dist/js/glightbox.min.js?v=10.3.9"></script> <script src="/modules/custom/glightbox/modules/glightbox_inline/js/glightbox_inline.js?sndln6"></script> <script src="/modules/contrib/simple_popup_blocks/js/simple_popup_blocks.js?v=10.3.9"></script> <script src="//use.fontawesome.com/f479fb1064.js"></script> <script src="/modules/contrib/extlink/js/extlink.js?v=10.3.9"></script> <script src="/modules/contrib/obfuscate_email/js/obfuscate_email.js?v=10.3.9"></script> <script src="/libraries/drupal-superfish/superfish.js?sndln6"></script> <script src="/libraries/drupal-superfish/sftouchscreen.js?sndln6"></script> <script src="/libraries/drupal-superfish/supposition.js?sndln6"></script> <script src="/libraries/drupal-superfish/supersubs.js?sndln6"></script> <script src="/modules/contrib/superfish/js/superfish.js?v=2.0"></script> <script src="//maxcdn.bootstrapcdn.com/bootstrap/3.3.7/js/bootstrap.min.js"></script> <script src="/themes/custom/showcase_lite/js/waypoints/jquery.waypoints.min.js?v=4.0.1"></script> <script src="/themes/custom/showcase_lite/js/waypoints/shortcuts/sticky.min.js?v=4.0.1"></script> <script src="/themes/custom/showcase_lite/js/init/waypoints-fixed-header-init.js?v=10.3.9"></script> <script> (function(){ var s = document.createElement('script'); var h = document.querySelector('head') || document.body; s.src = 'https://acsbapp.com/apps/app/dist/js/app.js'; s.async = true; s.onload = function(){ acsbJS.init({ statementLink : '', footerHtml : '', hideMobile : false, hideTrigger : false, disableBgProcess : false, language : 'en', position : 'right', leadColor : '#146FF8', triggerColor : '#146FF8', triggerRadius : '50%', triggerPositionX : 'right', triggerPositionY : 'bottom', triggerIcon : 'people', triggerSize : 'bottom', triggerOffsetX : 20, triggerOffsetY : 20, mobile : { triggerSize : 'small', triggerPositionX : 'right', triggerPositionY : 'bottom', triggerOffsetX : 20, triggerOffsetY : 20, triggerRadius : '20' } }); }; h.appendChild(s); })();</script> </body> </html> <script> if (jQuery('#block-peopletabs ul').height() > 60) { jQuery('#block-peopletabs').addClass('moby'); } if (jQuery('#block-biofulcrumtabs ul').height() > 60) { jQuery('#block-biofulcrumtabs').addClass('moby'); } if (jQuery('#block-donatetabs ul').height() > 60) { jQuery('#block-donatetabs').addClass('moby'); } if (jQuery('#block-trainingtabs ul').height() > 60) { jQuery('#block-trainingtabs').addClass('moby'); } if (jQuery('#block-clvtabs ul').height() > 60) { jQuery('#block-clvtabs').addClass('moby'); } if (jQuery('#block-institutetabs ul').height() > 120) { jQuery('#block-institutetabs').addClass('moby'); } if (jQuery('#block-institutetabs-2 ul').height() > 120) { jQuery('#block-institutetabs-2').addClass('moby'); } if (jQuery('#block-diversitytabs ul').height() > 60) { jQuery('#block-diversitytabs').addClass('moby'); } if (jQuery('#block-pumastabs-2 ul').height() > 60) { jQuery('#block-pumastabs-2').addClass('moby'); } if (jQuery('#mini-core-tabs ul').height() > 40) { jQuery('#mini-core-tabs').addClass('moby'); } if (jQuery('#block-mediatabs ul').height() > 60) { jQuery('#block-mediatabs').addClass('moby'); } if (jQuery('#block-ogawatabs ul').height() > 60) { jQuery('#block-ogawatabs').addClass('moby'); } if (jQuery('#block-nomistabs ul').height() > 60) { jQuery('#block-nomistabs').addClass('moby'); } </script> <script> jQuery(function() { jQuery('body').removeClass('fade-out'); }); </script> <script> jQuery(document).ready(function(){ jQuery(".pocus").click(function(){ jQuery("#search-input").fadeToggle(); }); jQuery('.spb_overlay').click(function () { jQuery("#spb-block-covidpopup").hide(); jQuery('body').css('overflowY', 'auto'); }); jQuery("#block-covidpopup").click(function () { window.location = "/news/gladstone-investigator-jennifer-doudna-wins-nobel-prize-chemistry"; }); }); var specifiedElement = document.getElementById('search-input'); var specifiedElement2 = document.getElementById('block-searchicon'); //I'm using "click" but it works with any event document.addEventListener('click', function(event) { var isClickInside = specifiedElement.contains(event.target); var orClickInside = specifiedElement2.contains(event.target); if (!isClickInside && !orClickInside ) { jQuery("#search-input").fadeOut(); } }); </script> <script> if (matchMedia('only screen and (min-width: 992px)').matches) { // desktop // Initial state var scrollPos = 0; // adding scroll event window.addEventListener('scroll', function(){ if(jQuery(window).scrollTop() <= 0) { jQuery('body').removeClass('onscroll'); } // detects new state and compares it with the new one if ((document.body.getBoundingClientRect()).top > scrollPos) jQuery('body').addClass('onscroll'); else jQuery('body').removeClass('onscroll'); // saves the new position for iteration. scrollPos = (document.body.getBoundingClientRect()).top; if(jQuery(window).scrollTop() <= 0) { jQuery('body').removeClass('onscroll'); } }); } </script> <script> jQuery('.owl-carousel').find('.owl-prev').attr('role','button').attr('title','Previous'); jQuery('.owl-carousel').find('.owl-next').attr('role','button').attr('title','Next'); jQuery('.owl-carousel, .owl-prev, .owl-next').attr('tabindex','0'); </script> <script src="/themes/custom/showcase_lite/js/smartquotes/smartquotes.js"></script> <script>smartquotes();</script>

CINXE.COM

BioFulcrum Viral and Infectious Disease Research Program | Gladstone Institutes