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HOPE Collaboratory | Gladstone Institutes
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But attempts to completely eliminate the virus from the bodies of people living with HIV, curing them for good, have failed. The HIV Obstruction by Programmed Epigenetics (HOPE) Collaboratory aims to both silence and permanently remove HIV from the body, by taking advantage of knowledge about how other viruses have become naturally inactivated over time." /> <link rel="canonical" href="https://gladstone.org/science/hope-collaboratory" /> <link rel="image_src" href="https://gladstone.org/sites/default/files/GladstoneShareImg2.jpg" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@GladstoneInst" /> <meta name="twitter:description" content="Over the last 40 years, HIV has shifted from a deadly and mysterious virus to one that can be controlled with daily drugs. But attempts to completely eliminate the virus from the bodies of people living with HIV, curing them for good, have failed. 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class="content"> <h1 class="title page-title"><span class="field field--name-title field--type-string field--label-hidden">HOPE Collaboratory</span> </h1> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="clearfix main-content region--dark-typography region--white-background region--no-separator"> <div class="landing-page-container" > <div class="clearfix main-content__container"> <div class="row"> <section> <div class="clearfix main-content__section" > <div class="region region-content"> <div id="block-showcase-lite-content" class="clearfix block block-system block-system-main-block"> <div class="content"> <article data-history-node-id="7869" class="node node--type-page node--view-mode-full clearfix"> <div class="node__container"> <div class="node__main-content clearfix"> <header class="node__header"> </header> <div class="container"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p class="large">Over the last 40 years, HIV has shifted from a deadly and mysterious virus to one that can be controlled with daily drugs. But attempts to completely eliminate the virus from the bodies of people living with HIV, curing them for good, have failed.</p> <p>The HIV Obstruction by Programmed Epigenetics (HOPE) Collaboratory aims to both silence and permanently remove HIV from the body, by taking advantage of knowledge about how other viruses have become naturally inactivated over time.</p> <p>HOPE researchers are focused on a novel “block-lock-excise” approach to find a cure for HIV that doesn’t require continuous treatment. This approach consists of using drugs to block the silent virus from reactivating, and then changing the DNA of latent HIV with gene editing approaches to permanently destroy the virus.</p> <p>The group is also engaging the community to help ensure that any resulting therapeutics are welcomed—and understood—by people living with HIV.</p> <p><a class="button magenta" href="https://hopeforhivcure.org/" target="_blank">Visit the Hope Website</a></p> <p>In August 2021, the HOPE Collaboratory received a $26.5-million grant (UM1AI164559) from the National Institutes of Health under its flagship program on HIV cure research, called the Martin Delaney Collaboratories program.</p> </div> </div> </div> </div> </article> </div> </div> <div id="block-hopecollaboratory" class="clearfix block block-block-content block-block-content488e97e2-9ca0-4ae7-862f-f5b88c3d4fc7"> <div class="content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p class="hopeimg hopeimg1"> </p><div class="container"><h2>The Team</h2><p>The Collaboratory is led by researchers at Gladstone Institutes, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, and Weill Cornell Medicine. HOPE includes members from 16 institutions around the world, and also works with two pharmaceutical companies with insight into the development of potential therapeutics from the drugs studied in the labs. In addition, clinical groups will help provide data and samples from people living with HIV in the United States, Africa, and Brazil.</p><h2>Leadership</h2><div class="col-sm-6"><p><strong>Melanie Ott, MD, PhD</strong><br>Program Director and Co-Principal Investigator HOPE Collaboratory<br>Director, Gladstone Institute of Virology</p><p><strong>Lishomwa Ndhlovu, MD, PhD</strong><br>Co-Principal Investigator, HOPE Collaboratory<br>Weill Cornell Medicine</p><p><strong>Susana Valente, PhD</strong><br>Co-Principal Investigator, HOPE Collaboratory<br>The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology</p><p><strong>Nadia Roan, PhD</strong><br>Research Focus 2 Co-Leader, HOPE Collaboratory<br>Senior Investigator, Gladstone Institutes</p><p><strong>Priti Kumar, PhD</strong><br>Research Focus 3 Co-Leader, HOPE Collaboratory<br>Yale University School of Medicine</p></div><div class="col-sm-6"><p><strong>Doug Nixon, MD, PhD</strong><br>Research Focus 1 Co-Leader, HOPE Collaboratory<br>Weill Cornell Medicine</p><p><strong>Patricia Defechereux, PhD</strong><br>Community Engagement Coordinator, HOPE Collaboratory<br>Gladstone Institutes</p><p><strong>Robert Furler O'Brien, PhD</strong><br>Program Manager, HOPE Collaboratory<br>Weill Cornell Medicine</p><p><strong>Sydney Norman</strong><br>Project Coordinator, HOPE Collaboratory<br>Gladstone Institutes</p></div></div><div class="after-leaders container"><p>In addition, the HOPE Collaboratory includes 10 members and four consultants from organizations around the world. It also works in partnership with the Last Gift Study at UC San Diego and the African Cohort Study (AFRICOS) at the US Military HIV Research Program, as well as with the San Francisco AIDS Foundation and industry partners Amgen, Sangamo Therapeutics, and Provirex.</p></div><p class="hopeimg hopeimg2"> </p><div class="container"><div class="partner-logos"><div class="row"><div class="three-col c-one"><img src="/sites/default/files/background-images/scrippslogo.png" data-entity-uuid data-entity-type alt="Scripps Research logo" width="370" height="116" loading="lazy"></div><div class="three-col c-two"><img src="/sites/default/files/background-images/gladstonelogo.png" data-entity-uuid data-entity-type alt="Gladstone logo" width="370" height="116" loading="lazy"></div><div class="three-col c-three"><img src="/sites/default/files/background-images/weillcornelllogo.png" data-entity-uuid data-entity-type alt="Weill Cornell Medicine logo" width="370" height="116" loading="lazy"></div></div></div></div><p class="hopegroupic"><img src="/sites/default/files/background-images/hopesymposiumgroup.jpg" data-entity-uuid data-entity-type alt width="1400" height="463" loading="lazy"></p></div> </div> </div> <div id="block-hopecss" class="clearfix block block-block-content block-block-contenta20958b9-339c-438b-ae4a-d52831ca0f55"> <div class="content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style> #block-hopecss {height:1px} #block-hopecollaboratory {margin-bottom:-74px} p.large{margin-top:23px} h2:nth-of-type(1){margin-bottom:29px} h2:nth-of-type(2){margin-top:23px;margin-bottom:28px} .hopeimg {width:100%; height:434px; background-repeat:no-repeat; background-size:cover} .hopeimg1{background-image: url('/sites/default/files/inline-images/HopeCollaboratory1.jpg');margin-top:-32px;margin-bottom:44px;background-position:right } .hopeimg2{background-image: 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url('/sites/default/files/background-images/hopesymposiumgroup.jpg');background-size:cover;background-position:center} .hopegroupic img {display:none} .three-col {text-align:center; padding-bottom:24px} .c-one img {padding-left:40px} } </style></div> </div> </div> <div id="block-hopenews" class="clearfix block block-block-content block-block-content0d86319a-d718-45b8-ba3f-7cd8fc1ca732"> <div id="related-news" class="container"> <h2>Recent News</h2> <div class="owl-carousel"> <a href="/news/closing-loopholes-current-hiv-therapy" title="Read more" target="_self"><div class="item"><img alt="HIV study" class="owl-lazy" data-src="/sites/default/files/styles/news_card/public/news-events/_bbb9404.jpg?itok=bf0BfAby" /><div class="blowpic">Closing the Loopholes of Current HIV Therapy<br><div class="summy">Scientists say it may be possible to drive the virus into “deep latency” by targeting the cellular process of transcription, by which lingering HIV cells continue to produce viral components.</div><div class="authored"><time datetime="2024-10-14T05:03:37-07:00" class="datetime">October 14, 2024</time> </div></div></div></a><a href="/news/how-understanding-rna-structure-can-help-researchers-design-better-hiv-drugs" title="Read more" target="_self"><div class="item"><img alt="Gladstone Senior Staff Research Scientist Ursula Schulze-Gahmen and Research Associate II Maria McCavitt-Malvido" class="owl-lazy" data-src="/sites/default/files/styles/news_card/public/news-events/nature_schulze-gahmen_hero.jpg?itok=QbjZXhek" /><div class="blowpic">How Understanding RNA Structure Can Help Researchers Design Better HIV Drugs<br><div class="summy">New research sheds light on the biological effect of the many possible three-dimensional structures of a critical loop of RNA in HIV</div><div class="authored"><time datetime="2023-07-10T11:28:28-07:00" class="datetime">July 10, 2023</time> </div></div></div></a><a 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