Cancer epidemiology

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<div class="u-mb-32" data-promo-text data-promo-text-threshold="650"> <p>Cancer is one of leading causes of mortality worldwide. Therefore, understanding incidence and mortality trends for each cancer is a public health priority in many countries. This Collection compiles articles that describe geographical and temporal patterns of incidence, mortality, risk factor exposures, public health interventions, screening, treatment and access to care for several cancer types.</p> </div> </div> <div class="l-with-sidebar__sidebar u-mb-24" style="--with-sidebar--basis: 450px"> <img src="https://media.springernature.com/w580h326/nature-cms/uploads/collections/NRCO-epidemiology-Collection-i1-33a9e41a9b3f0c0bc881da6126ded415.jpg" alt="charts overlaid on a world map "> </div> </div> </div> <section class="u-container u-mb-48" data-track-component="collection article grid" aria-labelledby="ReviewsandPerspectives"> <h2 id="ReviewsandPerspectives" class="c-section-heading">Reviews and Perspectives</h2> <ul class="c-list-group c-list-group--lg c-list-group--bordered c-list-group--flush app-article-list-row"> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-024-00904-z/MediaObjects/41571_2024_904_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00904-z/MediaObjects/41571_2024_904_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00904-z/MediaObjects/41571_2024_904_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00904-z" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Epidemiology of HPV-associated cancers past, present and future: towards prevention and elimination</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Lessons from the prevention of cervical cancer, the first cancer type deemed amenable to elimination, can provide information on strategies to manage other cancers. Infection with human papillomavirus (HPV) causes virtually all cervical cancers and an important proportion of other cancer types. The authors of this Review discuss the epidemiology of HPV-associated cancers and the potential for their elimination, focusing on the cofactors that could have the greatest effect on prevention efforts and health equity.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Talía Malagón</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Eduardo L. Franco</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Salvatore Vaccarella</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-05-17" itemprop="datePublished">17 May 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="/nrclinonc" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Reviews Clinical Oncology</a></span> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-024-00881-3/MediaObjects/41571_2024_881_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00881-3/MediaObjects/41571_2024_881_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00881-3/MediaObjects/41571_2024_881_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00881-3" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Global epidemiology of epithelial ovarian cancer</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Ovarian cancer, accounting for 4.7% of cancer deaths in women in 2020, remains highly prevalent globally. Nonetheless, owing to changes in environmental exposures, the approach to preventive measures and disease classification, both incidence and mortality have been declining in economically developed countries since the early 2000s. Conversely, parts of Asia and eastern Europe have seen increases in the incidence of ovarian cancer over this period of time. In this Review, the authors summarize the epidemiology of ovarian cancer, including the roles of the various risk factors and the potential for prevention.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Penelope M. Webb</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Susan J. Jordan</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-03-28" itemprop="datePublished">28 Mar 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="/nrclinonc" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Reviews Clinical Oncology</a></span> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-023-00844-0/MediaObjects/41571_2023_844_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00844-0/MediaObjects/41571_2023_844_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00844-0/MediaObjects/41571_2023_844_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-023-00844-0" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Lung cancer in patients who have never smoked — an emerging disease</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Lung cancer is a disease typically associated with tobacco smoking; however, lung cancer in individuals who have never smoked (LCINS) is estimated to be the fifth most common cause of cancer-related deaths globally. Moreover, smoking rates are declining around the world and therefore LCINS is likely to increase as a proportion of all lung cancers over time. Thus, understanding the aetiology and features of LCINS is increasingly important. Herein, the authors review the emerging data on the epidemiology, clinical characteristics and molecular features of LCINS as well as the genetic and environmental risk factors for this disease. They also summarize the unique diagnostic and management paradigms of LCINS.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Jaclyn LoPiccolo</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Alexander Gusev</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Pasi A. Jänne</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-01-09" itemprop="datePublished">9 Jan 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="/nrclinonc" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Reviews Clinical Oncology</a></span> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-023-00825-3/MediaObjects/41571_2023_825_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00825-3/MediaObjects/41571_2023_825_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00825-3/MediaObjects/41571_2023_825_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-023-00825-3" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Hepatocellular carcinoma (HCC) is among the most common causes of cancer-related death globally, and despite improvements in prevention and treatment strategies, continued increases in HCC incidence and mortality are predicted. Cirrhosis remains the major risk factor for HCC, although the underlying aetiology is shifting from virus-related to non-viral liver diseases. In this Review, the authors discuss the changing trends in HCC epidemiology and their implications for screening, prevention and therapy, including opportunities to further improve the management of patients with, or at high risk of, HCC.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Amit G. Singal</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Fasiha Kanwal</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Josep M. Llovet</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2023-10-26" itemprop="datePublished">26 Oct 2023</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="/nrclinonc" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Reviews Clinical Oncology</a></span> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-023-00802-w/MediaObjects/41571_2023_802_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00802-w/MediaObjects/41571_2023_802_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00802-w/MediaObjects/41571_2023_802_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-023-00802-w" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Improving quality and quantity of life for childhood cancer survivors globally in the twenty-first century</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Advances in the treatment of childhood cancers have substantially improved cure rates, although the gains in survival are offset by an elevated burden of morbidities and an excess risk of early death owing predominantly to the adverse effects of therapy. In this Review, the authors summarize the evolution of paediatric cancer therapies over the past five decades as well as the associated landscape of treatment-related late and/or long-term health conditions experienced by childhood cancer survivors. In addition, they discuss strategies that are being explored to reduce the overall burden and consequences of these morbidities with the ultimate aim of improving not only the quantity but also the quality of life-years gained for this large, medically vulnerable population.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Matthew J. Ehrhardt</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Kevin R. Krull</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Melissa M. Hudson</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2023-07-24" itemprop="datePublished">24 Jul 2023</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="/nrclinonc" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Reviews Clinical Oncology</a></span> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-023-00798-3/MediaObjects/41571_2023_798_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00798-3/MediaObjects/41571_2023_798_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00798-3/MediaObjects/41571_2023_798_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-023-00798-3" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">The global burden of lung cancer: current status and future trends</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Lung cancer is the commonest cancer globally. Reflecting patterns of smoking and other risk factor exposures, both the incidence of and mortality from lung cancer are highest in economically developed countries. Nonetheless, developing and less economically developed countries are likely to have the biggest increases in lung cancer in the coming years. In this Review, the authors describe the global epidemiology of lung cancer, and how changes in exposures, socioeconomic status, public health interventions and better treatment strategies are influencing both the incidence of and mortality from lung cancer.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Amanda Leiter</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Rajwanth R. Veluswamy</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Juan P. Wisnivesky</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2023-07-21" itemprop="datePublished">21 Jul 2023</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="/nrclinonc" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Reviews Clinical Oncology</a></span> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-023-00747-0/MediaObjects/41571_2023_747_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00747-0/MediaObjects/41571_2023_747_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00747-0/MediaObjects/41571_2023_747_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-023-00747-0" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Globally, gastric cancer is a common and highly fatal cancer with two anatomical subtypes, non-cardia and cardia gastric cancer. <i>Helicobacter pylori</i> causes almost 90% of distal gastric cancers worldwide. The authors of this Review summarize the current epidemiology of gastric cancer and the evidence and implications of primary and secondary prevention efforts.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Aaron P. Thrift</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Theresa Nguyen Wenker</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Hashem B. El-Serag</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2023-03-23" itemprop="datePublished">23 Mar 2023</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="/nrclinonc" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Reviews Clinical Oncology</a></span> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-023-00744-3/MediaObjects/41571_2023_744_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00744-3/MediaObjects/41571_2023_744_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-023-00744-3/MediaObjects/41571_2023_744_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-023-00744-3" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Global trends in the epidemiology of bladder cancer: challenges for public health and clinical practice</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Bladder cancer is among the ten most common cancers worldwide and therefore constitutes a substantial health-care burden. This Review summarizes the global trends in bladder cancer incidence and mortality, and describes the main risk factors associated with bladder cancer occurrence and outcomes. The implications, challenges and opportunities of these epidemiological trends for public health and clinical practice are also discussed.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Lisa M. C. van Hoogstraten</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Alina Vrieling</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Lambertus A. Kiemeney</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2023-03-13" itemprop="datePublished">13 Mar 2023</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="/nrclinonc" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Reviews Clinical Oncology</a></span> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-022-00672-8/MediaObjects/41571_2022_672_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-022-00672-8/MediaObjects/41571_2022_672_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-022-00672-8/MediaObjects/41571_2022_672_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-022-00672-8" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Is early-onset cancer an emerging global epidemic? Current evidence and future implications</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>The incidence of early-onset forms of many cancers (defined as cancers diagnosed in individuals <50 years of age) has increased in a number of countries over the past several decades. The underlying reasons for this apparent increase probably include greater use of screening programmes, but also changing patterns in early-life exposures. 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The authors of this Perspective discuss how population-level approaches with amenable goals should be considered an integral part of cancer control.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Isabelle Soerjomataram</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Freddie Bray</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Perspective</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2021-06-02" itemprop="datePublished">2 Jun 2021</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="/nrclinonc" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Reviews Clinical Oncology</a></span> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-020-00445-1/MediaObjects/41571_2020_445_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-020-00445-1/MediaObjects/41571_2020_445_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-020-00445-1/MediaObjects/41571_2020_445_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-020-00445-1" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Rising incidence of early-onset colorectal cancer — a call to action</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>The incidence of early-onset colorectal cancer (CRC) is increasing worldwide for reasons that are currently unclear. 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In this Perspective, the authors describe changes in cancer incidence and death rates in the USA, highlighting the effects of specific policies and research developments, and providing insight into unmet needs that should be addressed by future health policies.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Farhad Islami</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Rebecca L. 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