Nature Reviews Clinical Oncology

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M. Williams</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Allyson M. Peddle</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Sabine Tejpar</span></li> </ul> <div class="c-meta u-color-inherit"> <span class="c-meta__item"> <span class="c-meta__type">Review Article</span> </span> <time class="c-meta__item" datetime="2024-09-24" itemprop="datePublished">24 September 2024</time> </div> </div> </div> </div> </div> </article> <section id="featured-content" class="u-mb-48 u-mt-24" data-track-component="featured content grid"> <div class="u-container"> <div class="c-section-heading" data-test="title"> <h2 class="u-ma-0"> Featured </h2> </div> <ul class="app-article-list-row"> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-024-00934-7/MediaObjects/41571_2024_934_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00934-7/MediaObjects/41571_2024_934_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00934-7/MediaObjects/41571_2024_934_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00934-7" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Translating biological insights into improved management of endometrial cancer</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Endometrial cancer is the commonest gynaecological cancer in economically developed countries, and both the incidence and mortality continue to increase. This increasing prevalence highlights the need for novel treatment approaches that will improve patient outcomes. In this Review, the authors describe the epidemiology and standard-of-care treatment approaches for patients with endometrial cancer, as well as highlighting the importance of understanding tumour biology and incorporating this knowledge into better-informed treatment strategies for specific subgroups of patients.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Jeffrey A. How</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Amir A. Jazaeri</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Karen H. Lu</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-08-28" itemprop="datePublished">28 Aug 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-024-00937-4/MediaObjects/41571_2024_937_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00937-4/MediaObjects/41571_2024_937_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00937-4/MediaObjects/41571_2024_937_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00937-4" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Immunotherapy for ovarian cancer: towards a tailored immunophenotype-based approach</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Although ovarian cancer is considered an immunoreactive disease, moderate to no efficacy has been shown in the trials testing immune-checkpoint inhibitors in these patients performed thus far. The authors of this Review summarize these results and propose a systematic classification of ovarian cancer based on CD8<sup>+</sup> T cell immunophenotypes that, integrated with genetic data, can enable the design of tailored therapeutic approaches, including adoptive cell therapy and novel immunotherapy combinations.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Eleonora Ghisoni</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Matteo Morotti</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">George Coukos</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-09-04" itemprop="datePublished">04 Sept 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-024-00939-2/MediaObjects/41571_2024_939_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00939-2/MediaObjects/41571_2024_939_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00939-2/MediaObjects/41571_2024_939_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00939-2" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Dual HER2 inhibition: mechanisms of synergy, patient selection, and resistance</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Patients with HER2<sup>+</sup> breast cancer often respond to trastuzumab, although acquired resistance is common and can involve a range of mechanisms. reflecting the highly heterogeneous biology of this breast cancer subtype. In this Review, the authors describe the role of dual HER2 blockade, involving the co-administration of two HER2-targeted therapies (including monoclonal antibodies, tyrosine kinase inhibitors and antibody–drug conjugates) in patients with HER2<sup>+</sup> breast cancer.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Adrienne G. Waks</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Olga Martínez-Sáez</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Aleix Prat</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-09-13" itemprop="datePublished">13 Sept 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00945-4" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Two decades of advances in clinical oncology — lessons learned and future directions</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Since the publication of the first issue of <i>Nature Reviews Clinical Oncology</i>, we have witnessed advances in multiple research areas that have culminated in improved outcomes for many cancer types, although substantial unmet needs remain for a majority of patients worldwide. Here, we have asked experts in several key specialities to reflect on the progress from the past 20 years and propose the next steps to enable further advances. Although we are aware that this Viewpoint cannot provide full coverage of the vast field that is clinical oncology, we hope that these messages inspire a diverse range of readers.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Susana Banerjee</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Christopher M. Booth</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Yi-Long Wu</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Viewpoint</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-10-01" itemprop="datePublished">01 Oct 2024</time> </div> </article> </div> </li> </ul> </div> </section> <section id="latest-issue" data-track-component="latest-issue grid"> <div class="u-container u-mb-48"> <div class="c-section-heading"> <h2 class="u-ma-0"> <a href="/nrclinonc/current-issue" class="c-section-heading__link" data-track="click" data-track-action="view all" data-track-label="button"> Current issue <svg class="c-section-heading__icon" aria-hidden="true" focusable="false" height="16" width="16"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-chevron-right"></use></svg> </a> </h2> </div> <div class="app-latest-issue-row"> <div class="app-latest-issue-row__main u-display-flex u-flex-direction-column u-flex-shrink"> <ul class="app-latest-issue-row__article-list"> <li class="app-latest-issue-row__item"><div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00942-7" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">New clinical trials in CUP and a novel paradigm in cancer classification</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Elie Rassy</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Fabrice André</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Comment</span></span><time class="c-meta__item" datetime="2024-09-11" itemprop="datePublished">11 Sept 2024</time> </div> </article> </div></li> <li class="app-latest-issue-row__item"><div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00944-5" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Vorasidenib: a new hope or a false promise for patients with low-grade glioma?</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Stanislav Lazarev</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Kunal K. 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M. Williams</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Allyson M. Peddle</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Sabine Tejpar</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item" datetime="2024-09-24" itemprop="datePublished">24 Sept 2024</time> </div> </article> </div></li> <li class="app-latest-issue-row__item"><div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00946-3" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Molecular imaging supports the development of multispecific cancer antibodies</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Claudia A. J. van Winkel</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Frank R. Pierik</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Marjolijn N. Lub-de Hooge</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item" datetime="2024-09-26" itemprop="datePublished">26 Sept 2024</time> </div> </article> </div></li> <li class="app-latest-issue-row__item"><div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00956-1" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Navigating the changing landscape of BTK-targeted therapies for B cell lymphomas and chronic lymphocytic leukaemia</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Michele D. Stanchina</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Skye Montoya</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Juan Pablo Alderuccio</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item" datetime="2024-11-01" itemprop="datePublished">01 Nov 2024</time> </div> </article> </div></li> </ul> </div> <div class="app-latest-issue-row__side"> <div class="app-latest-issue-row__image"> <picture> <source type="image/webp" srcset="https://media.springernature.com/w440/springer-static/cover-hires/journal/41571/21/12?as=webp&q=95"> <img src="https://media.springernature.com/w440/springer-static/cover-hires/journal/41571/21/12?q=95" alt="Volume 21 Issue 12" itemprop="image"> </picture> </div> <div class="app-latest-issue-row__buttons app-latest-issue-row--by-3"> <div class="app-latest-issue-row__button"> <a href="/nrclinonc/current-issue" class="u-button u-button--full-width" data-track="click" data-track-action="view current issue" data-track-label="button">Contents</a> </div> <div class="app-latest-issue-row__button"> <a href="/nrclinonc/volumes/21" class="u-button u-button--full-width" data-track="click" data-track-action="click view all issues">View all issues</a> </div> <div class="app-latest-issue-row__button"><a href="/nrclinonc/subscribe" class="u-button u-button--primary u-button--full-width" data-track="click" data-track-action="subscribe" data-track-label="button">Subscribe</a></div> </div> </div> </div> </div> </section> <section id="announcement-content" class="u-mb-48 u-mt-24" data-track-component="announcement content grid"> <div class="u-container"> <div class="c-section-heading" data-test="title"> <h2 class="u-ma-0"> Announcements </h2> </div> <ul class="app-announcement-list-row"> <li class="app-announcement-list-row__item"> <article class="c-card c-card--flush u-pl-0 u-justify-content-space-between"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/nature-cms/uploads/mosaic_featured_form_item/6623/announcement-image-901ac0a41eccf63dd74f36989484b892.jpg?as=webp 160w, https://media.springernature.com/w290h158/nature-cms/uploads/mosaic_featured_form_item/6623/announcement-image-901ac0a41eccf63dd74f36989484b892.jpg?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img data-test="image-0" src="https://media.springernature.com/w290h158/nature-cms/uploads/mosaic_featured_form_item/6623/announcement-image-901ac0a41eccf63dd74f36989484b892.jpg" alt="colourful chart" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline" data-test="announcement-title-0"> <a href="https://www.nature.com/articles/s41571-024-00943-6" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="click on homepage featured announcement" data-track-label="announcement 0"> Article freely available </a> </h3> <div class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description" data-test="description-0"> <p>The article "Neoadjuvant immunotherapy for dMMR and pMMR colorectal cancers: therapeutic strategies and putative biomarkers of response" from C. J. M. Williams, A. M. Peddle et al. will be freely available while the December issue is featured on the journal's homepage</p> </div> </div> </div> </article> </li> <li class="app-announcement-list-row__item"> <article class="c-card c-card--flush u-pl-0 u-justify-content-space-between"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/nature-cms/uploads/mosaic_featured_form_item/6623/announcement-image-1fe7f4e46af13180e571cccac1d06aff.jpg?as=webp 160w, https://media.springernature.com/w290h158/nature-cms/uploads/mosaic_featured_form_item/6623/announcement-image-1fe7f4e46af13180e571cccac1d06aff.jpg?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img data-test="image-1" src="https://media.springernature.com/w290h158/nature-cms/uploads/mosaic_featured_form_item/6623/announcement-image-1fe7f4e46af13180e571cccac1d06aff.jpg" alt="celebratory cup of tea" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline" data-test="announcement-title-1"> <a href="https://www.nature.com/collections/cjdfcggcbc" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="click on homepage featured announcement" data-track-label="announcement 1"> 20 years of Nature Reviews Clinical Oncology </a> </h3> <div class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description" data-test="description-1"> <p>In this Collection, we compile some of the most popular contents published over 20 years – including some specially commissioned contents</p> </div> </div> </div> </article> </li> <li class="app-announcement-list-row__item"> <article class="c-card c-card--flush u-pl-0 u-justify-content-space-between"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" 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Allogeneic products have the potential to address many of these issues, but come with their own challenges. This Review summarizes the advantages and disadvantages of allogeneic CAR cell products derived from T cells or other immune cells, their engineering and progress towards clinical implementation, as well as hurdles that remain to be overcome.</p> </div> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Caroline Diorio</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">David T. Teachey</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Stephan A. 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These data provide a meaningful advance; however, this strategy might not be right for all patients, and careful consideration is recommended before blanket use.</p> </div> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Joshua Drago</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Shanu Modi</span></li> </ul> </div> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">News & Views</span></span><time class="c-meta__item" datetime="2024-11-06" itemprop="datePublished">06 Nov 2024</time> </div> </article> </div> </li> <li class="app-reviews-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00964-1" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">On the cusp of targeted therapy for cancer cachexia — what clinical benefits might we promise our patients?</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>A number of therapeutics that target mediators of signalling in the hypothalamic and brainstem regions that control appetite, ingestive behaviour, satiety, nausea and vomiting are starting to move the needle on cancer cachexia. However, clarification of meaningful clinical benefits for patients and the primary end points that should support regulatory approval of cachexia treatments is needed.</p> </div> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Vickie E. Baracos</span></li> </ul> </div> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">News & Views</span></span><time class="c-meta__item" datetime="2024-11-05" itemprop="datePublished">05 Nov 2024</time> </div> </article> </div> </li> <li class="app-reviews-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41571-024-00956-1/MediaObjects/41571_2024_956_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00956-1/MediaObjects/41571_2024_956_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41571-024-00956-1/MediaObjects/41571_2024_956_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-024-00956-1" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Navigating the changing landscape of BTK-targeted therapies for B cell lymphomas and chronic lymphocytic leukaemia</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>In several B cell malignancies, BTK is a crucial mediator of oncogenic signalling pathways and inhibitors of this kinase have substantially improved patient outcomes. This Review discusses the currently approved indications for covalent and non-covalent BTK inhibitors, as well as mechanisms of resistance, and novel BTK-targeted agents and treatment strategies that have the potential to further improve outcomes.</p> </div> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Michele D. 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