Chang Lab for Liver Tissue Engineering - Homepage

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class="menu-item"> <a href="https://herniacenter.ucsf.edu/">Center for Hernia Repair & Abdominal Wall Reconstruction</a> </li> <li class="menu-item"> <a href="https://limbpreservation.ucsf.edu/">Center for Limb Preservation & Diabetic Foot</a> </li> <li class="menu-item"> <a href="https://geriatricsurgery.ucsf.edu/">Center for Surgery in Older Adults</a> </li> <li class="menu-item"> <a href="https://colorectalsurgery.ucsf.edu/">Colorectal Surgery</a> </li> <li class="menu-item"> <a href="https://endocrinesurgery.ucsf.edu/">Endocrine Surgery</a> </li> <li class="menu-item"> <a href="https://eras.ucsf.edu/">Enhanced Recovery After Surgery (ERAS)</a> </li> <li class="menu-item"> <a href="https://surgery.ucsf.edu/list-of-external-sites/fetal-treatment-center">Fetal Treatment Center</a> </li> <li class="menu-item"> <a href="https://gisurgery.ucsf.edu/">Gastrointestinal Surgery</a> </li> <li class="menu-item"> <a href="https://generalsurgery.ucsf.edu/">General Surgery</a> </li> <li 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href="https://surgeryfap.ucsf.edu/">Faculty Affairs & Development Portal</a> </li> <li class="menu-item"> <a href="https://medstudentsurgery.ucsf.edu/">Medical Student Portal</a> </li> <li class="menu-item"> <a href="https://murielsteelesociety.ucsf.edu/">Muriel Steele Society</a> </li> <li class="menu-item"> <a href="https://plasticsurgeryresidency.ucsf.edu/">Plastic Surgery Residency</a> </li> <li class="menu-item"> <a href="https://surgeryresidentportal.ucsf.edu/">Resident Portal</a> </li> <li class="menu-item"> <a href="https://surgeryresidentresearch.ucsf.edu/">Resident Research</a> </li> <li class="menu-item"> <a href="https://npfellowship.ucsf.edu/">Surgical & Critical Care NP Fellowship</a> </li> <li class="menu-item"> <a href="https://surgeryeducation.ucsf.edu/">Surgery Education Portal</a> </li> <li class="menu-item"> <a href="https://surgeryresearch.ucsf.edu/">Surgery Research Portal</a> </li> <li class="menu-item"> <a href="https://surgicalskillslab.ucsf.edu/">Surgical Skills Center</a> </li> <li class="menu-item"> <a href="https://thoracicsurgeryresidency.ucsf.edu/">Thoracic Surgery Residency</a> </li> <li class="menu-item"> <a href="https://t32surgicaloncology.ucsf.edu/">T32 Surgical Oncology</a> </li> <li class="menu-item"> <a href="https://t32transplantsurgery.ucsf.edu/">T32 Research Training in Transplant Surgery</a> </li> <li class="menu-item"> <a href="https://ucsf-eastbay.squarespace.com/">UCSF-East Bay General Surgery Residency</a> </li> <li class="menu-item"> <a href="https://vascularsurgeryresidency.ucsf.edu/">Vascular Surgery Integrated Residency Program</a> </li> </ul> </div> </li> <li class="menu-item menu-item--expanded"> <div role="group" aria-labelledby="ResearchWebsites" class="col"> <h2 id="ResearchWebsites" class="col-head" tabindex="0"> <span>Research Websites</span> </h2> <ul class="menu"> <li class="menu-item"> <a href="https://raffailab.ucsf.edu/">Atherosclerosis Research Lab</a> </li> <li class="menu-item"> <a href="https://surgerybiostat.ucsf.edu/">Biostatistics Core</a> </li> <li class="menu-item"> <a href="https://cardiacbiomechanicslab.ucsf.edu/">Cardiac Biomechanics Lab</a> </li> <li class="menu-item"> <a href="https://mindfulsurgeon.ucsf.edu/">Center for Mindfulness in Surgery</a> </li> <li class="menu-item"> <a href="https://livertissueengineering.ucsf.edu/">Chang Laboratory for Liver Tissue Engineering</a> </li> <li class="menu-item"> <a href="https://contelab.ucsf.edu/">Conte Lab</a> </li> <li class="menu-item"> <a href="https://endocrineneoplasialab.ucsf.edu/">Endocrine Neoplasia Research Lab</a> </li> <li class="menu-item"> <a href="https://itl.ucsf.edu/">Immunogenetics & Transplantation Lab</a> </li> <li class="menu-item"> <a href="https://kornblithlab.ucsf.edu/">Kornblith Lab</a> </li> <li class="menu-item"> <a href="https://kratzlab.ucsf.edu/">Kratz Lab</a> </li> <li class="menu-item"> <a href="https://lobularbreastcancer.ucsf.edu/">Lobular Breast Cancer Research Program</a> 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<div class="content-carousel-card-content"> <div class="heading"> <div class="field field--name-field-heading field--type-string field--label-hidden field__item">The Chang Laboratory for Liver Tissue Engineering</div> </div> </div> </div> </div> </div> </div> </div> <div class="field__item"> <div > <div class="columns text-vert-align--top remove-top-padding columns--layout-sidebar-left paragraph paragraph--type--kan-columns paragraph--view-mode--default no-decor"> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <article class="media media--type-image media--view-mode-rounded-overlay" aria-label="Image about Dr Tammy Chang"> <div class="corner-detail mobile"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="50px" height="50px" viewBox="0 0 50 50" style="enable-background:new 0 0 50 50;" 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href="/bio/tammy-t-chang-md-phd" data-entity-type="node" data-entity-uuid="8583e53b-27dd-4064-bbb3-552092c0a156" data-entity-substitution="canonical">Tammy T. Chang, MD, PhD</a></h3><p style="font-size:1rem;">Professor of Surgery<br>Division of General Surgery</p> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <h2 style="margin-top:0px;">Translating Regenerative Surgery on the Liver From Concept to Therapeutic Reality</h2><div class="lab_content_textarea_top"><p>Tissue engineering and regeneration are the next evolutionary step in surgical practice. As surgeons, we resect, reconstruct, and transplant to treat a diverse array of diseases resulting from acute inflammation, congenital malformation, malignancy, or organ failure. In the near future, our armamentarium will increase to include using our surgical skills to induce tissue regeneration in situ or to implant ex vivo engineered organs. Accelerating advances in biotechnology, stem cell biology, and minimally invasive surgery are ripe for convergence, which will lead to the creation of novel surgical treatments to replace diseased or dysfunctional tissues. Our lab's goal is to make significant contributions to bringing these regenerative surgical therapies from the lab into the operating room.</p><p><a class="btn-outline-editor" href="/chang-lab-about" data-entity-type="node" data-entity-uuid="28122d3e-dcea-45fc-ae40-2a53130c66d5" data-entity-substitution="canonical">Read More</a></p></div> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item news-for-lab"> <div > <div class="columns text-vert-align--top remove-top-padding columns--layout-column-wider-left paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="field field--name-field-heading field--type-string field--label-hidden field__item">Featured News</div> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="filtered-list paragraph paragraph--type--kan-filtered-list paragraph--view-mode--default"> <div class="filtered-list__view"> <div class="field field--name-kan-field-views field--type-viewsreference field--label-hidden field__item"><div class="views-element-container"><div class="view view-news-events view-id-news_events view-display-id-featured_article_block js-view-dom-id-da0505fbe7c081a9a45d6757b943bf14058dc6ee77a9ada5e45f569371d4020e"> <div class="view-content"> <div class="views-row"> <article data-history-node-id="138571" class="node node--type-news node--view-mode-featured"> <div> <div class="corner-detail mobile"> <svg width="50" height="50" viewBox="0 0 50 50" fill="none" xmlns="http://www.w3.org/2000/svg"> <mask id="path-1-inside-1_3369_102218" fill="white"> <path d="M0 0H50V50H0V0Z"/> </mask> <path d="M0 0V-5H-5V0H0ZM0 5H50V-5H0V5ZM5 50V0H-5V50H5Z" fill="#FEB80A" mask="url(#path-1-inside-1_3369_102218)"/> </svg> </div> <div class="corner-detail desktop"> <svg width="100" height="100" viewBox="0 0 100 100" fill="none" xmlns="http://www.w3.org/2000/svg"> <mask id="path-1-inside-1_3369_104160" fill="white"> <path d="M0 0H100V100H0V0Z"/> </mask> <path d="M0 0V-5H-5V0H0ZM0 5H100V-5H0V5ZM5 100V0H-5V100H5Z" fill="#FEB80A" mask="url(#path-1-inside-1_3369_104160)"/> </svg> </div> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__items"> <div class="field__item"> <article class="media media--type-image media--view-mode-news-featured" aria-label="Image about Group Photo for ACS news item"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_featured/public/2024-10/Group-ACS-banner.webp?h=0abf8b4b&itok=EYTgEPmp 1308w" sizes="(min-width: 1290px) 81.75rem, (min-width: 768px) 100vw, (min-width: 560px) 100vw" width="1308" height="935" src="/sites/default/files/styles/news_featured/public/2024-10/Group-ACS-banner.webp?h=0abf8b4b&itok=EYTgEPmp" alt="Group Photo for ACS news item" /> </div> </article> </div> </div> <div class="featured-news-text-wrapper"> <p class="content-title"> <div class="ext__link field field--name-title field--type-string field--label-hidden field__item" target="_blank"><a href="https://www.facs.org/media-center/press-releases/2024/how-liver-tissue-from-the-international-space-station-may-transform-tissue-engineering/" class="ext__link field field--name-title field--type-string field--label-hidden field__item" target="_blank">How Liver Tissue from the International Space Station May Transform Tissue Engineering </a></div> </p> <svg class="yellow-arrow" width="6" height="8" viewBox="0 0 6 8" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M6 4L-3.26266e-07 7.4641L-2.34249e-08 0.535898L6 4Z" fill="#FEB80A"/> </svg> <a href="https://www.facs.org/media-center/press-releases/2024/how-liver-tissue-from-the-international-space-station-may-transform-tissue-engineering/" class="featured-story-link" rel="bookmark">Read full story</a> </div> </div> </article> </div> </div> </div> </div> </div> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="filtered-list paragraph paragraph--type--kan-filtered-list paragraph--view-mode--default"> <div class="filtered-list__view"> <div class="field field--name-kan-field-views field--type-viewsreference field--label-hidden field__item"><div class="views-element-container"><div class="news-with-readmore view view-news-events view-id-news_events view-display-id-block_3 js-view-dom-id-2578c81b17052481b88d0f789f259f5b3308909ebf6a084ecc30110b3bec2580"> <div class="view-header"> <style> .news-with-readmore .more-link { margin-top: 18px; 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Chang, MD, PhD Awarded NASA and National Science Foundation Grants to Study Microgravity in Biological Systems</a> </div> </div> <div class="more-link"><a href="/news">View All News</a></div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item"> <div > <div class="columns text-vert-align--top remove-top-padding columns--layout-column-wider-left paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <h2>Chang Lab Gallery </h2><a href="/chang-lab-gallery"> <article class="media media--type-image media--view-mode-rounded-overlay" aria-label="Image about Chang Lab Conferences"> <div class="corner-detail mobile"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="50px" height="50px" 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-webkit-appearance: none; -moz-appearance: none; appearance: none; position: relative; font-size: 1rem; padding: 0.625rem 1.25rem; background-color: transparent; color: #14828c; border-color: #14828c; } .view-publications-for-lab .more-link:hover { color: #052049; border-color: #052049; } .view-publications-for-lab .more-link a { text-decoration:none;} .view-publications-for-lab .more-link a::before { content: ""; width: 100%; height: 100%; outline: 0.25rem solid transparent; position: absolute; top: 0; left: 0; border-radius: 30px; } .view-publications-for-lab .more-link a:hover::before { outline-color: #052049; } </style> </div> <div class="view-content"> <div class="item-list pubs-outerlist"> <ol> <li><span class="views-field views-field-title"><span class="field-content"><b>Metastatic melanoma to small bowel: metastasectomy is supported in the era of immunotherapy and checkpoint inhibitors.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2024 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/38468341">PubMed</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>Irreversible Electroporation of the Liver Increases the Transplant Engraftment of Hepatocytes.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2023 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/37738854">PubMed</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>Isochoric Supercooling Organ Preservation System.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2023 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/37627819">PubMed</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>An exploratory study on isochoric supercooling preservation of the pig liver.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2023 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/37229422">PubMed</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>Self-Assembled Matrigel-Free iPSC-Derived Liver Organoids Demonstrate Wide-Ranging Highly Differentiated Liver Functions.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2023 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/36573434">PubMed</a> </span></span></li> </ol> </div> </div> <div class="more-link"><a href="/chang-lab-publications">View All Publications</a></div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> </div> <div><style> .paragraph--type--small-cta .field--name-field-title h2 { font-size: 2rem; } .highlite-area { background-color:#fefdee; border:gray 1px solid; padding:14px; } @media (min-width: 64em) { .text-block__title > h2::after { content: ""; width: 100%; display: inline-block; height: 2px; border-bottom: 2px solid #feb80a; margin-left: 1.5rem; margin-right: -100%; } } @media (min-width: 64em) { .text-block__title > h2 { overflow: hidden; width:100% !important; max-width:100% !important; } } .text-block__title > h2 { text-align: left; margin-bottom: 3rem !important; line-height: 1.25; letter-spacing: -0.04rem; } 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