Immunogenetics and Transplantation Laboratory (ITL) - Homepage

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</div> <div class="content-carousel-card-wrapper desktop"> <div class="media-container"> <div class="corner-detail desktop"> <svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" width="100px" height="100px" viewbox="0 0 100 100" style="enable-background:new 0 0 100 100;" xml:space="preserve"> <style type="text/css"> .st0 { fill: none; stroke: #FEB80A; stroke-width: 5; stroke-miterlimit: 10; } </style> <polyline class="st0" points="2.5,100 2.5,2.5 100,2.5 "/> </svg> </div> <article class="media media--type-image media--view-mode-con" aria-label="Image about High-throughput HLA antibody screening with minimal MFI variation"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/kan_max_2600x2600/public/2024-11/itl-homepage-banners6.webp?itok=p7OJWTli" width="2600" height="1463" alt="High-throughput HLA antibody screening with minimal MFI variation" class="image-style-kan-max-2600x2600" /> </div> </article> <div class="vector vector-top desktop"> <svg viewbox="0 0 1440 31" fill="none" xmlns="http://www.w3.org/2000/svg"> <mask id="mask0_3317_107350" style="mask-type:alpha" maskunits="userSpaceOnUse" x="0" y="0" width="1440" height="31"> <rect width="1440" height="31" fill="#D9D9D9"/> </mask> <g mask="url(#mask0_3317_107350)"> <path d="M0 -46.8823C97.5525 -32.6474 109.164 -0.823154 260.949 18.9397C310.483 25.3889 365.586 22.3005 421.356 5.50924C421.356 5.50924 473.745 -13.4426 520.917 -28.0149C587.174 -48.4849 606.019 -43.0738 714.185 -18.9704C826.647 6.09318 928.321 -42.53 1016.16 -28.0149C1104 -13.4998 1155.5 3.5 1207.95 19.2446C1260.4 34.9892 1322 30.3939 1345 25.5002C1368 20.6066 1440 10.8402 1440 10.8402" stroke="#CACED2" stroke-miterlimit="10"/> <path d="M0 24.8783C117.417 24.8783 183.404 19.6813 268.393 11.0586C336.261 4.17467 497.027 -24.931 565.316 -27.1305C755.443 -33.2683 767.879 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xml:space="preserve"> <style type="text/css"> .st0 { fill: none; stroke: #FEB80A; stroke-width: 5; stroke-miterlimit: 10; } </style> <polyline class="st0" points="2.5,100 2.5,2.5 100,2.5 "/> </svg> </div> <article class="media media--type-image media--view-mode-con" aria-label="Image about Real-time PCR approach for rapid HLA typing"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/kan_max_2600x2600/public/2024-11/itl-homepage-banners5.webp?itok=nMLIPgS0" width="2600" height="1463" alt="Real-time PCR approach for rapid HLA typing" class="image-style-kan-max-2600x2600" /> </div> </article> <div class="vector vector-top desktop"> <svg viewbox="0 0 1440 31" fill="none" xmlns="http://www.w3.org/2000/svg"> <mask id="mask0_3317_107350" style="mask-type:alpha" maskunits="userSpaceOnUse" x="0" y="0" width="1440" height="31"> <rect width="1440" height="31" fill="#D9D9D9"/> </mask> <g 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74.8802 1 74.8802" stroke="#CACED2" stroke-miterlimit="10"/> <path d="M1441 40.6085C1413.31 41.8672 1347.95 52.4947 1282.34 37.8121C1224.37 24.8424 1157.5 -8 1074.02 15.9147C990.54 39.8295 854.696 41.4105 790.852 36.5055C731.859 31.9703 699.904 31.62 640.079 29.427C538.688 25.7093 499.769 35.9695 395.448 39.8299C367.758 41.0886 325.915 34.1723 266.187 37.8121C206.459 41.4455 176.113 28.5776 114.057 30.5389C52 32.5003 35.5 37.8121 1 40.6103" stroke="#CACED2" stroke-miterlimit="10"/> <path d="M1441 74.8783C1323.58 74.8783 1257.6 69.6813 1172.61 61.0586C1104.74 54.1747 943.973 25.069 875.684 22.8695C685.557 16.7317 673.121 76.085 424.847 74.8783C213.911 68.1778 184.5 36.5007 116 15.5004C47.5 -5.5 1 3.12031 1 3.12031" stroke="#CACED2" stroke-miterlimit="10"/> </svg> </div> </div> <div class="content-carousel-card-content"> <div class="body"> <div class="clearfix text-formatted field field--name-field-body field--type-text field--label-hidden field__item">Real-time PCR approach for rapid HLA typing</div> </div> </div> </div> </div> </div> </div> </div> <div class="field__item"> <div > <div class="columns text-vert-align--top remove-top-padding columns--layout-sidebar-left paragraph paragraph--type--kan-columns paragraph--view-mode--default no-decor"> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <article class="align-center media media--type-image media--view-mode-rounded-overlay" aria-label="Image about raja_rajalingam"> <div class="corner-detail mobile"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="50px" height="50px" viewBox="0 0 50 50" style="enable-background:new 0 0 50 50;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,50 2.5,2.5 50,2.5 " /> </svg> </div> <div class="corner-detail desktop"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="100px" height="100px" viewBox="0 0 100 100" style="enable-background:new 0 0 100 100;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,100 2.5,2.5 100,2.5 " /> </svg> </div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/rounded_overlay/public/2023-10/raja_rajalingam-354x210.jpg.webp?itok=cf5TTqKC" width="354" height="210" alt="raja_rajalingam" class="image-style-rounded-overlay"> </div> </article> <h3><a class="bio-title" href="/bio/rajalingam-raja-phd-fachi-frcp" rel="bookmark"><span class="field field--name-title field--type-string field--label-hidden">Rajalingam Raja, PhD, F(ACHI), FRCP</span></a></h3><p style="font-size:1.1rem;">Clinical Professor of Surgery <br>Director, Immunogenetics and Transplantation Laboratory</p><div class="mission"><div class="mission-header"><h3> </h3></div></div> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <div class="lab_front_heading" id="sg_contentHeading"><h1 class="sg_frontPageH1">Diagnostic Testing, Research & Education</h1><div class="lab_content_textarea_top"><p><span style="font-size:inherit;">The UCSF Immunogenetics and Transplantation Laboratory (ITL) is a CLIA-certified, ASHI-accredited, CMS-approved freestanding histocompatibility laboratory licensed by both California and New York. Housed in a newly constructed, custom designed, state-of-the-art facility with approximately 10,000 square feet of laboratory space dedicated to histocompatibility and immunogenetics testing, ITL has state-of-the-art equipment and liquid handling systems to support quality high volume testing. </span></p><p>ITL provides diagnostic HLA testing services for therapeutic transplantation, disease associations, drug hypersensitivity, and transfusion services. ITL facilitates over 800 organ (kidney, liver, lung, heart, pancreas, and islet) and hematopoietic stem cell transplantations per year at UCSF. ITL serves as a contract laboratory for Donor Network West, the northern California organ procurement organization. As a freestanding HLA laboratory, the ITL provides services to non-UCSF clients including transplant programs in other states. </p><p>ITL is also a core HLA laboratory for the Immune Tolerance Network, a research cooperative focused on the development of therapeutic approaches for asthma and allergy, autoimmune diseases, and organ transplantation that lead to immune tolerance. ITL performs testing for clinical trials, and conducts basic and translational research in immunology, immunogenetics, molecular biology, and transplant immunology.  </p><p>In addition, ITL provides educational programs in immunogenetics and transplant immunology for healthcare professionals. </p></div></div><h2>Licenses and Certificates </h2><ul><li><a href="/sites/default/files/2024-11/2022-2024-clia_vn.pdf">Clinical Laboratory Improvement Amendments (CLIA)</a></li><li><a href="/sites/default/files/2024-11/2023-2025-ashi-accreditation.pdf">American Society for Histocompatibility and Immunogenetics (ASHI)</a></li><li><a href="/sites/default/files/2024-11/2024-2025-ca-lab-license_vn.pdf">California License</a></li><li><a href="/sites/default/files/2024-11/ny-lab-permit-2024-2025.pdf">New York License</a></li></ul> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item"> <div > <div class="quote__full-width"> <div class="quote-content"> <div class="field field--name-field-quote-text field--type-string-long field--label-hidden field__item"><q>The Immunogenetics and Transplantation Laboratory provides quality diagnostic testing, research, and education as vital contributions to optimal patient care and leadership in the advancement of our discipline.</q></div> <div class="name-proc-wrapper"> <a href="/bio/rajalingam-raja-phd-fachi-frcp" class="quote-credit-link" aria-label="Quote by Rajalingam Raja, Director, Immunogenetics &amp; Transplantation Lab"> <span class="field field--name-field-quote-credit field--type-string field--label-hidden field__item">Rajalingam Raja</span> </a> <span class="field field--name-field-quote-credit-detail field--type-string field--label-hidden field__item">Director, Immunogenetics & Transplantation Lab</span> </div> </div> </div> </div></div> <div class="field__item column-set-research"> <div > <div class="columns text-vert-align--top columns--layout-equal paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__title"> <h2>Collaborations</h2> </div> <div class="text-block__text"> <div class="research-area"><div><a href="https://immunox.ucsf.edu/"> <article class="align-center media media--type-image media--view-mode-content-width-inline-image" aria-label="Image about Bakar Immunox"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/umbraco/media/12145581/logo-color20ac9a35.png.webp?itok=pnOkKU81 325w, /sites/default/files/styles/max_875x875/public/umbraco/media/12145581/logo-color20ac9a35.png.webp?itok=2JleGBiA 580w" sizes="(min-width: 57.1875rem) 54.6875rem, calc(100vw - 2.5rem)" width="580" height="160" src="/sites/default/files/styles/max_325x325/public/umbraco/media/12145581/logo-color20ac9a35.png.webp?itok=pnOkKU81" alt="Bakar Immunox" title="Bakar Immunox"> </div> </article> </a></div><div><a href="http://cancer.ucsf.edu/"> <article class="align-center media media--type-image media--view-mode-content-width-inline-image" aria-label="Image about Cancer Center"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/umbraco/media/12145580/cancer-center.jpg.webp?itok=xRkGSmyR 325w, /sites/default/files/styles/max_875x875/public/umbraco/media/12145580/cancer-center.jpg.webp?itok=qqu_LdQF 540w" sizes="(min-width: 57.1875rem) 54.6875rem, calc(100vw - 2.5rem)" width="540" height="169" src="/sites/default/files/styles/max_325x325/public/umbraco/media/12145580/cancer-center.jpg.webp?itok=xRkGSmyR" alt="Cancer Center" title="Cancer Center"> </div> </article> </a></div><div><a href="http://hlacovid19.org/about/"> <article class="align-center media media--type-image media--view-mode-content-width-inline-image" aria-label="Image about HLA-COVID 19"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/umbraco/media/12145589/hla-covid-19.jpg.webp?itok=rAtLBz8x 325w, /sites/default/files/styles/max_650x650/public/umbraco/media/12145589/hla-covid-19.jpg.webp?itok=8PnuKkmU 650w, /sites/default/files/styles/max_875x875/public/umbraco/media/12145589/hla-covid-19.jpg.webp?itok=xA4woYQN 875w, /sites/default/files/styles/max_2600x2600/public/umbraco/media/12145589/hla-covid-19.jpg.webp?itok=LtOAxtdQ 1264w" sizes="(min-width: 57.1875rem) 54.6875rem, calc(100vw - 2.5rem)" width="875" height="544" src="/sites/default/files/styles/max_325x325/public/umbraco/media/12145589/hla-covid-19.jpg.webp?itok=rAtLBz8x" alt="HLA-COVID 19" title="HLA-COVID 19"> </div> </article> </a></div><div><a href="https://www.immunetolerance.org/"> <article class="align-center media media--type-image media--view-mode-content-width-inline-image" aria-label="Image about Bio -itn -logo -300w"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/max_875x875/public/umbraco/media/12145590/bio-itn-logo-300w.jpg.webp?itok=G1WI3133 300w" sizes="(min-width: 57.1875rem) 54.6875rem, calc(100vw - 2.5rem)" width="300" height="300" src="/sites/default/files/styles/max_325x325/public/umbraco/media/12145590/bio-itn-logo-300w.jpg.webp?itok=neXX_Ez2" alt="Bio -itn -logo -300w" title="Bio -itn -logo -300w"> </div> </article> </a></div></div><p><a class="btn-outline-editor" href="/node/1831" data-entity-type="node" data-entity-uuid="1de58cfd-8fdf-4fc2-940f-b47f341963f4" data-entity-substitution="canonical">Learn More</a></p> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__title"> <h2>Our Research</h2> </div> <div class="text-block__text"> <div style="margin-top:0px;"><div class="research-summary"><ol><li><div>Define the functional histocompatibility to increase the number of transplants and improve transplant outcomes by identifying acceptable HLA mismatches and tolerable donor-specific HLA antibodies (DSA)...</div></li><li><div>Understand the function of germline-encoded polymorphism of immunity related genes (HLA, KIR, KLR, and FcR) in human populations and their impact on infections, tumor transformation, autoimmune diseases, pregnancy success and allogeneic solid organ and bone marrow transplantation....</div></li><li><div>Genes encoding killer-cell Immunoglobulin-like receptors (KIR) and HLA class I ligands are located on different chromosomes, and both feature extraordinary diversity in the number and type of genes...</div></li></ol></div><p><a class="btn-outline-editor" href="/itl-research" title="Read more" aria-label="Read more" data-entity-type="node" data-entity-uuid="23a98188-0168-4625-a0bc-6eece478b797" data-entity-substitution="canonical">Read Full Research</a></p></div> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--small-cta paragraph--view-mode--default"> <div class="field field--name-field-title field--type-text field--label-hidden field__item"><h2>Support the Lab</h2></div> <div class="clearfix text-formatted field field--name-field-paragraph field--type-text-long field--label-hidden field__item"><p>Your generous support of the Immunogenetics and Transplantation Laboratory helps scientists discover new treatments for bone marrow, cornea transplantation and more.</p></div> <div class="field--name-field-link"> <a 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