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<div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein superfamily of small GTPases</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Hras_surface_colored_by_conservation.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/32/Hras_surface_colored_by_conservation.png/220px-Hras_surface_colored_by_conservation.png" decoding="async" width="220" height="209" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/32/Hras_surface_colored_by_conservation.png/330px-Hras_surface_colored_by_conservation.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/32/Hras_surface_colored_by_conservation.png/440px-Hras_surface_colored_by_conservation.png 2x" data-file-width="1300" data-file-height="1236" /></a></span><div class="infobox-caption"><a href="/wiki/HRAS" title="HRAS">H-Ras</a> structure <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> 121p, surface colored by conservation in <a href="/wiki/Pfam" title="Pfam">Pfam</a> seed alignment: gold, most conserved; dark cyan, least conserved.</div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">Ras</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a></th><td class="infobox-data pfam" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF00071">PF00071</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/InterPro" title="InterPro">InterPro</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR013753">IPR013753</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/PROSITE" title="PROSITE">PROSITE</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://prosite.expasy.org/PDOC00017">PDOC00017</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Structural_Classification_of_Proteins" class="mw-redirect" title="Structural Classification of Proteins">SCOP2</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://scop2.mrc-lmb.cam.ac.uk/search?t=txt;q=5p21">5p21</a> / <a rel="nofollow" class="external text" href="https://scop.berkeley.edu/pdb/code=5p21">SCOPe</a> / <a rel="nofollow" class="external text" href="http://supfam.org/SUPERFAMILY/cgi-bin/search.cgi?search_field=5p21">SUPFAM</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Conserved_Domain_Database" title="Conserved Domain Database">CDD</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00882">cd00882</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Membranome_database" title="Membranome database">Membranome</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://membranome.org/protein_superfamilies/206">206</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Available protein structures:</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Pfam" title="Pfam">Pfam</a>  </th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="http://pfam.xfam.org/family/PF00071?tab=pdbBlock">structures</a> / <a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/search?kw=PF00071">ECOD</a>  </td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_annotation.annotation_id:PF00071%20AND%20rcsb_polymer_entity_annotation.type:Pfam">RCSB PDB</a>; <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?pfam_accession:PF00071">PDBe</a>; <a rel="nofollow" class="external text" href="https://pdbj.org/search/pdb?other_db_select=PFam&other_db_field=PF00071">PDBj</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PDBsum" title="PDBsum">PDBsum</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF00071">structure summary</a></td></tr></tbody></table></td></tr></tbody></table> <p>The <b>Ras superfamily</b>, derived from "Rat sarcoma virus", is a <a href="/wiki/Protein_superfamily" title="Protein superfamily">protein superfamily</a> of <a href="/wiki/Small_GTPase" title="Small GTPase">small GTPases</a>.<sup id="cite_ref-pmid15731001_1-0" class="reference"><a href="#cite_note-pmid15731001-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Members of the superfamily are divided into <a href="/wiki/Protein_family" title="Protein family">families</a> and subfamilies based on their structure, sequence and function. The five main families are Ras, <a href="/wiki/Rho_family_of_GTPases" title="Rho family of GTPases">Rho</a>, <a href="/wiki/Ran_(biology)" class="mw-redirect" title="Ran (biology)">Ran</a>, <a href="/wiki/Rab_(G-protein)" title="Rab (G-protein)">Rab</a> and <a href="/wiki/ADP_ribosylation_factor" title="ADP ribosylation factor">Arf</a> GTPases.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> The Ras family itself is further divided into 6 subfamilies: <a href="/wiki/Ras_subfamily" class="mw-redirect" title="Ras subfamily">Ras</a>, <a href="/wiki/RALA" title="RALA">Ral</a>, <a href="/wiki/Rap_(protein)" class="mw-redirect" title="Rap (protein)">Rap</a>, <a href="/wiki/Rheb" class="mw-redirect" title="Rheb">Rheb</a>, <a href="/wiki/RRAD_(gene)" title="RRAD (gene)">Rad</a> and Rit. <i>Miro</i> is a recent contributor to the superfamily. Each subfamily shares the common core G domain, which provides essential GTPase and nucleotide exchange activity. </p><p>The surrounding sequence helps determine the functional specificity of the small GTPase, for example the 'Insert Loop', common to the Rho subfamily, specifically contributes to binding to effector proteins such as <a href="/wiki/Wiskott-Aldrich_syndrome_protein" class="mw-redirect" title="Wiskott-Aldrich syndrome protein">WASP</a>. </p><p>In general, the Ras family is responsible for cell proliferation: Rho for cell <a href="/wiki/Morphology_(biology)" title="Morphology (biology)">morphology</a>, Ran for nuclear transport, and Rab and Arf for <a href="/wiki/Vesicle_(biology_and_chemistry)" title="Vesicle (biology and chemistry)">vesicle</a> transport.<sup id="cite_ref-Munemitsu_3-0" class="reference"><a href="#cite_note-Munemitsu-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Subfamilies_and_members">Subfamilies and members</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ras_superfamily&action=edit&section=1" title="Edit section: Subfamilies and members"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The following is a list of human proteins belonging to the Ras superfamily:<sup id="cite_ref-pmid15731001_1-1" class="reference"><a href="#cite_note-pmid15731001-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <table class="wikitable" style="text-align:center"> <caption>Overview </caption> <tbody><tr> <th>Subfamily</th> <th>Function</th> <th>Members </th></tr> <tr> <td><a href="/wiki/Ras_subfamily" class="mw-redirect" title="Ras subfamily">Ras</a> </td> <td><a href="/wiki/Cell_proliferation" title="Cell proliferation">cell proliferation</a><sup id="cite_ref-Munemitsu_3-1" class="reference"><a href="#cite_note-Munemitsu-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </td> <td align="left"><a href="/wiki/DIRAS1" title="DIRAS1">DIRAS1</a>; <a href="/w/index.php?title=DIRAS2&action=edit&redlink=1" class="new" title="DIRAS2 (page does not exist)">DIRAS2</a>; <a href="/wiki/DIRAS3" class="mw-redirect" title="DIRAS3">DIRAS3</a>; <a href="/w/index.php?title=ERAS_(gene)&action=edit&redlink=1" class="new" title="ERAS (gene) (page does not exist)">ERAS</a>; <a href="/wiki/GEM_(gene)" title="GEM (gene)">GEM</a>; <a href="/wiki/HRAS" title="HRAS">HRAS</a>; <a href="/wiki/KRAS" title="KRAS">KRAS</a>; <a href="/wiki/MRAS" title="MRAS">MRAS</a>; <a href="/w/index.php?title=NKIRAS1&action=edit&redlink=1" class="new" title="NKIRAS1 (page does not exist)">NKIRAS1</a>; <a href="/wiki/NKIRAS2" title="NKIRAS2">NKIRAS2</a>; <a href="/wiki/Neuroblastoma_RAS_viral_oncogene_homolog" title="Neuroblastoma RAS viral oncogene homolog">NRAS</a>; <a href="/wiki/RALA" title="RALA">RALA</a>; <a href="/wiki/RALB" title="RALB">RALB</a>; <a href="/wiki/RAP1A" title="RAP1A">RAP1A</a>; <a href="/wiki/RAP1B" title="RAP1B">RAP1B</a>; <a href="/wiki/RAP2A" title="RAP2A">RAP2A</a>; <a href="/wiki/RAP2B" title="RAP2B">RAP2B</a>; <a href="/w/index.php?title=RAP2C&action=edit&redlink=1" class="new" title="RAP2C (page does not exist)">RAP2C</a>; <a href="/wiki/RASD1" title="RASD1">RASD1</a>; <a href="/wiki/RASD2" title="RASD2">RASD2</a>; <a href="/w/index.php?title=RASL10A&action=edit&redlink=1" class="new" title="RASL10A (page does not exist)">RASL10A</a>; <a href="/w/index.php?title=RASL10B&action=edit&redlink=1" class="new" title="RASL10B (page does not exist)">RASL10B</a>; <a href="/w/index.php?title=RASL11A&action=edit&redlink=1" class="new" title="RASL11A (page does not exist)">RASL11A</a>; <a href="/wiki/RASL11B" title="RASL11B">RASL11B</a>; <a href="/w/index.php?title=RASL12&action=edit&redlink=1" class="new" title="RASL12 (page does not exist)">RASL12</a>; <a href="/w/index.php?title=REM1&action=edit&redlink=1" class="new" title="REM1 (page does not exist)">REM1</a>; <a href="/w/index.php?title=REM2&action=edit&redlink=1" class="new" title="REM2 (page does not exist)">REM2</a>; <a href="/wiki/RERG" title="RERG">RERG</a>; <a href="/w/index.php?title=RERGL&action=edit&redlink=1" class="new" title="RERGL (page does not exist)">RERGL</a>; <a href="/wiki/RRAD_(gene)" title="RRAD (gene)">RRAD</a>; <a href="/wiki/RRAS" title="RRAS">RRAS</a>; <a href="/wiki/RRAS2" title="RRAS2">RRAS2</a> </td></tr> <tr> <td><a href="/wiki/Rho_family" class="mw-redirect" title="Rho family">Rho</a> </td> <td><a href="/wiki/Cytoskeletal" class="mw-redirect" title="Cytoskeletal">cytoskeletal</a> dynamics/morphology<sup id="cite_ref-Munemitsu_3-2" class="reference"><a href="#cite_note-Munemitsu-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </td> <td align="left"><a href="/wiki/RHOA" class="mw-redirect" title="RHOA">RHOA</a>; <a href="/wiki/RHOB" title="RHOB">RHOB</a>; <a href="/wiki/RHOBTB1" title="RHOBTB1">RHOBTB1</a>; <a href="/wiki/RHOBTB2" title="RHOBTB2">RHOBTB2</a>; <a href="/wiki/RHOBTB3" title="RHOBTB3">RHOBTB3</a>; <a href="/wiki/RhoC" title="RhoC">RHOC</a>; <a href="/wiki/RhoD" title="RhoD">RHOD</a>; <a href="/w/index.php?title=RhoF&action=edit&redlink=1" class="new" title="RhoF (page does not exist)">RHOF</a>; <a href="/wiki/RHOG" class="mw-redirect" title="RHOG">RHOG</a>; <a href="/wiki/RhoH" title="RhoH">RHOH</a>; <a href="/wiki/RHOJ" title="RHOJ">RHOJ</a>; <a href="/wiki/RHOQ" title="RHOQ">RHOQ</a>; <a href="/w/index.php?title=RHOU&action=edit&redlink=1" class="new" title="RHOU (page does not exist)">RHOU</a>; <a href="/wiki/RHOV" class="mw-redirect" title="RHOV">RHOV</a>; <a href="/wiki/Rnd1" title="Rnd1">RND1</a>; <a href="/wiki/Rnd2" title="Rnd2">RND2</a>; <a href="/wiki/Rnd3" title="Rnd3">RND3</a>; <a href="/wiki/RAC1" title="RAC1">RAC1</a>; <a href="/wiki/Rac2" class="mw-redirect" title="Rac2">RAC2</a>; <a href="/wiki/RAC3" title="RAC3">RAC3</a>; <a href="/wiki/CDC42" title="CDC42">CDC42</a> </td></tr> <tr> <td><a href="/wiki/Rab_(G-protein)" title="Rab (G-protein)">Rab</a> </td> <td><a href="/wiki/Membrane_trafficking" class="mw-redirect" title="Membrane trafficking">membrane trafficking</a> </td> <td align="left"><a href="/wiki/RAB1A" title="RAB1A">RAB1A</a>; <a href="/wiki/RAB1B" title="RAB1B">RAB1B</a>; <a href="/w/index.php?title=RAB2&action=edit&redlink=1" class="new" title="RAB2 (page does not exist)">RAB2</a>; <a href="/wiki/RAB3A" title="RAB3A">RAB3A</a>; <a href="/wiki/RAB3B" title="RAB3B">RAB3B</a>; <a href="/wiki/RAB3C" title="RAB3C">RAB3C</a>; <a href="/wiki/RAB3D" title="RAB3D">RAB3D</a>; <a href="/wiki/RAB4A" title="RAB4A">RAB4A</a>; <a href="/wiki/RAB4B" title="RAB4B">RAB4B</a>; <a href="/wiki/RAB5A" title="RAB5A">RAB5A</a>; <a href="/wiki/RAB5B" title="RAB5B">RAB5B</a>; <a href="/wiki/RAB5C" title="RAB5C">RAB5C</a>; <a href="/wiki/RAB6A" title="RAB6A">RAB6A</a>; <a href="/wiki/RAB6B" title="RAB6B">RAB6B</a>; <a href="/wiki/RAB6C" title="RAB6C">RAB6C</a>; <a href="/wiki/RAB7A" title="RAB7A">RAB7A</a>; <a href="/wiki/RAB7B" title="RAB7B">RAB7B</a>; <a href="/wiki/RAB7L1" title="RAB7L1">RAB7L1</a>; <a href="/wiki/RAB8A" title="RAB8A">RAB8A</a>; <a href="/wiki/RAB8B" title="RAB8B">RAB8B</a>; <a href="/w/index.php?title=RAB9&action=edit&redlink=1" class="new" title="RAB9 (page does not exist)">RAB9</a>; <a href="/w/index.php?title=RAB9B&action=edit&redlink=1" class="new" title="RAB9B (page does not exist)">RAB9B</a>; <a href="/w/index.php?title=RABL2A&action=edit&redlink=1" class="new" title="RABL2A (page does not exist)">RABL2A</a>; <a href="/w/index.php?title=RABL2B&action=edit&redlink=1" class="new" title="RABL2B (page does not exist)">RABL2B</a>; <a href="/w/index.php?title=RABL4&action=edit&redlink=1" class="new" title="RABL4 (page does not exist)">RABL4</a>; <a href="/wiki/RAB10" title="RAB10">RAB10</a>; <a href="/wiki/RAB11A" title="RAB11A">RAB11A</a>; <a href="/wiki/RAB11B" title="RAB11B">RAB11B</a>; <a href="/w/index.php?title=RAB12&action=edit&redlink=1" class="new" title="RAB12 (page does not exist)">RAB12</a>; <a href="/wiki/RAB13" title="RAB13">RAB13</a>; <a href="/wiki/RAB14" title="RAB14">RAB14</a>; <a href="/wiki/RAB15" title="RAB15">RAB15</a>; <a href="/wiki/RAB17" title="RAB17">RAB17</a>; <a href="/wiki/RAB18" title="RAB18">RAB18</a>; <a href="/w/index.php?title=RAB19&action=edit&redlink=1" class="new" title="RAB19 (page does not exist)">RAB19</a>; <a href="/w/index.php?title=RAB20&action=edit&redlink=1" class="new" title="RAB20 (page does not exist)">RAB20</a>; <a href="/wiki/RAB21" title="RAB21">RAB21</a>; <a href="/wiki/RAB22A" title="RAB22A">RAB22A</a>; <a href="/wiki/RAB23" title="RAB23">RAB23</a>; <a href="/w/index.php?title=RAB24&action=edit&redlink=1" class="new" title="RAB24 (page does not exist)">RAB24</a>; <a href="/wiki/RAB25" title="RAB25">RAB25</a>; <a href="/wiki/RAB26" title="RAB26">RAB26</a>; <a href="/wiki/RAB27A" title="RAB27A">RAB27A</a>; <a href="/w/index.php?title=RAB27B&action=edit&redlink=1" class="new" title="RAB27B (page does not exist)">RAB27B</a>; <a href="/w/index.php?title=RAB28&action=edit&redlink=1" class="new" title="RAB28 (page does not exist)">RAB28</a>; <a href="/wiki/RAB2B" title="RAB2B">RAB2B</a>; <a href="/wiki/RAB30" title="RAB30">RAB30</a>; <a href="/wiki/RAB31" title="RAB31">RAB31</a>; <a href="/w/index.php?title=RAB32&action=edit&redlink=1" class="new" title="RAB32 (page does not exist)">RAB32</a>; <a href="/wiki/RAB33A" title="RAB33A">RAB33A</a>; <a href="/wiki/RAB33B" title="RAB33B">RAB33B</a>; <a href="/wiki/RAB34" title="RAB34">RAB34</a>; <a href="/wiki/RAB35" title="RAB35">RAB35</a>; <a href="/wiki/RAB36" title="RAB36">RAB36</a>; <a href="/wiki/RAB37" title="RAB37">RAB37</a>; <a href="/wiki/RAB38" title="RAB38">RAB38</a>; <a href="/w/index.php?title=RAB39&action=edit&redlink=1" class="new" title="RAB39 (page does not exist)">RAB39</a>; <a href="/wiki/RAB39B" title="RAB39B">RAB39B</a>; <a href="/wiki/RAB40A" title="RAB40A">RAB40A</a>; <a href="/w/index.php?title=RAB40AL&action=edit&redlink=1" class="new" title="RAB40AL (page does not exist)">RAB40AL</a>; <a href="/w/index.php?title=RAB40B&action=edit&redlink=1" class="new" title="RAB40B (page does not exist)">RAB40B</a>; <a href="/w/index.php?title=RAB40C&action=edit&redlink=1" class="new" title="RAB40C (page does not exist)">RAB40C</a>; <a href="/w/index.php?title=RAB41&action=edit&redlink=1" class="new" title="RAB41 (page does not exist)">RAB41</a>; <a href="/w/index.php?title=RAB42&action=edit&redlink=1" class="new" title="RAB42 (page does not exist)">RAB42</a>; <a href="/w/index.php?title=RAB43&action=edit&redlink=1" class="new" title="RAB43 (page does not exist)">RAB43</a> </td></tr> <tr> <td><a href="/wiki/Rap_(protein)" class="mw-redirect" title="Rap (protein)">Rap</a> </td> <td><a href="/wiki/Cell_adhesion" title="Cell adhesion">cellular adhesion</a> </td> <td align="left"><a href="/wiki/RAP1A" title="RAP1A">RAP1A</a>; <a href="/wiki/RAP1B" title="RAP1B">RAP1B</a>; <a href="/wiki/RAP2A" title="RAP2A">RAP2A</a>; <a href="/wiki/RAP2B" title="RAP2B">RAP2B</a>; <a href="/w/index.php?title=RAP2C&action=edit&redlink=1" class="new" title="RAP2C (page does not exist)">RAP2C</a> </td></tr> <tr> <td><a href="/wiki/ADP_ribosylation_factor" title="ADP ribosylation factor">Arf</a> </td> <td><a href="/wiki/Vesicular_transport" class="mw-redirect" title="Vesicular transport">vesicular transport</a><sup id="cite_ref-Munemitsu_3-3" class="reference"><a href="#cite_note-Munemitsu-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </td> <td align="left"><a href="/wiki/ARF1" title="ARF1">ARF1</a>; <a href="/wiki/ARF3" title="ARF3">ARF3</a>; <a href="/wiki/ARF4" title="ARF4">ARF4</a>; <a href="/wiki/ARF5" title="ARF5">ARF5</a>; <a href="/wiki/Arf6" class="mw-redirect" title="Arf6">ARF6</a>; <a href="/wiki/ARL1" title="ARL1">ARL1</a>; <a href="/wiki/ARL2" title="ARL2">ARL2</a>; <a href="/wiki/ARL3" title="ARL3">ARL3</a>; <a href="/w/index.php?title=ARL4&action=edit&redlink=1" class="new" title="ARL4 (page does not exist)">ARL4</a>; <a href="/w/index.php?title=ARL5&action=edit&redlink=1" class="new" title="ARL5 (page does not exist)">ARL5</a>; <a href="/w/index.php?title=ARL5C&action=edit&redlink=1" class="new" title="ARL5C (page does not exist)">ARL5C</a>; <a href="/wiki/ARL6" title="ARL6">ARL6</a>; <a href="/w/index.php?title=ARL7&action=edit&redlink=1" class="new" title="ARL7 (page does not exist)">ARL7</a>; <a href="/w/index.php?title=ARL8&action=edit&redlink=1" class="new" title="ARL8 (page does not exist)">ARL8</a>; <a href="/w/index.php?title=ARL9&action=edit&redlink=1" class="new" title="ARL9 (page does not exist)">ARL9</a>; <a href="/w/index.php?title=ARL10A&action=edit&redlink=1" class="new" title="ARL10A (page does not exist)">ARL10A</a>; <a href="/w/index.php?title=ARL10B&action=edit&redlink=1" class="new" title="ARL10B (page does not exist)">ARL10B</a>; <a href="/w/index.php?title=ARL10C&action=edit&redlink=1" class="new" title="ARL10C (page does not exist)">ARL10C</a>; <a href="/wiki/ARL11" title="ARL11">ARL11</a>; <a href="/wiki/ARL13A" title="ARL13A">ARL13A</a>; <a href="/wiki/ARL13B" title="ARL13B">ARL13B</a>; <a href="/w/index.php?title=ARL14&action=edit&redlink=1" class="new" title="ARL14 (page does not exist)">ARL14</a>; <a href="/wiki/ARL15" title="ARL15">ARL15</a>; <a href="/w/index.php?title=ARL16&action=edit&redlink=1" class="new" title="ARL16 (page does not exist)">ARL16</a>; <a href="/w/index.php?title=ARL17&action=edit&redlink=1" class="new" title="ARL17 (page does not exist)">ARL17</a>; <a href="/wiki/TRIM23" title="TRIM23">TRIM23</a>, <a href="/wiki/ARL4D" title="ARL4D">ARL4D</a>; <a href="/wiki/ARFRP1" title="ARFRP1">ARFRP1</a>; <a href="/wiki/ARL13B" title="ARL13B">ARL13B</a> </td></tr> <tr> <td><a href="/wiki/Ran_(biology)" class="mw-redirect" title="Ran (biology)">Ran</a> </td> <td><a href="/wiki/Nuclear_transport" title="Nuclear transport">nuclear transport</a> </td> <td align="left"><a href="/wiki/Ran_(biology)" class="mw-redirect" title="Ran (biology)">RAN</a> </td></tr> <tr> <td><a href="/wiki/Rheb" class="mw-redirect" title="Rheb">Rheb</a> </td> <td><a href="/wiki/MTOR" title="MTOR">mTOR</a> pathway </td> <td align="left"><a href="/wiki/RHEB" title="RHEB">RHEB</a>; <a href="/w/index.php?title=RHEBL1&action=edit&redlink=1" class="new" title="RHEBL1 (page does not exist)">RHEBL1</a> </td></tr> <tr> <td><a href="/wiki/RRAD_(gene)" title="RRAD (gene)">RGK</a> </td> <td> </td> <td align="left"><a href="/wiki/RRAD_(gene)" title="RRAD (gene)">RRAD</a>; <a href="/wiki/GEM_(gene)" title="GEM (gene)">GEM</a>; <a href="/w/index.php?title=REM_(gene)&action=edit&redlink=1" class="new" title="REM (gene) (page does not exist)">REM</a>; <a href="/w/index.php?title=REM2&action=edit&redlink=1" class="new" title="REM2 (page does not exist)">REM2</a> </td></tr> <tr> <td><i><style data-mw-deduplicate="TemplateStyles:r1238216509">.mw-parser-output .vanchor>:target~.vanchor-text{background-color:#b1d2ff}@media screen{html.skin-theme-clientpref-night .mw-parser-output .vanchor>:target~.vanchor-text{background-color:#0f4dc9}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .vanchor>:target~.vanchor-text{background-color:#0f4dc9}}</style><span class="vanchor"><span id="Rit"></span><span class="vanchor-text">Rit</span></span></i> </td> <td align="left"> </td> <td align="left"><a href="/wiki/RIT1" title="RIT1">RIT1</a>; <a href="/wiki/RIT2" title="RIT2">RIT2</a> </td></tr> <tr> <td><i><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238216509"><span class="vanchor"><span id="Miro"></span><span class="vanchor-text">Miro</span></span></i> </td> <td><a href="/wiki/Mitochondria" class="mw-redirect" title="Mitochondria">mitochondrial</a> transport </td> <td align="left"><a href="/wiki/RHOT1" title="RHOT1">RHOT1</a>; <a href="/wiki/RHOT2" title="RHOT2">RHOT2</a> </td></tr></tbody></table> <p>Unclassified: </p> <ul><li><a href="/wiki/ARHGAP5" title="ARHGAP5">ARHGAP5</a></li> <li><a href="/w/index.php?title=DNAJC27&action=edit&redlink=1" class="new" title="DNAJC27 (page does not exist)">DNAJC27</a></li> <li><a href="/wiki/GRLF1" title="GRLF1">GRLF1</a></li> <li><a href="/wiki/RASEF" title="RASEF">RASEF</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ras_superfamily&action=edit&section=2" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Ras_subfamily" class="mw-redirect" title="Ras subfamily">Ras subfamily</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ras_superfamily&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-pmid15731001-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid15731001_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid15731001_1-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFWennerbergRossmanDer2005" class="citation journal cs1">Wennerberg K, Rossman KL, Der CJ (March 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.01660">"The Ras superfamily at a glance"</a>. <i>J. Cell Sci</i>. <b>118</b> (Pt 5): 843–6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.01660">10.1242/jcs.01660</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15731001">15731001</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Cell+Sci.&rft.atitle=The+Ras+superfamily+at+a+glance&rft.volume=118&rft.issue=Pt+5&rft.pages=843-6&rft.date=2005-03&rft_id=info%3Adoi%2F10.1242%2Fjcs.01660&rft_id=info%3Apmid%2F15731001&rft.aulast=Wennerberg&rft.aufirst=K&rft.au=Rossman%2C+KL&rft.au=Der%2C+CJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1242%252Fjcs.01660&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARas+superfamily" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGoitreTrapaniTrabalziniRetta2013" class="citation book cs1">Goitre, L; Trapani, E; Trabalzini, L; Retta, SF (26 December 2013). <i>The Ras superfamily of small GTPases: the unlocked secrets</i>. Methods in Molecular Biology. Vol. 1120. pp. 1–18. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2F978-1-62703-791-4_1">10.1007/978-1-62703-791-4_1</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-62703-790-7" title="Special:BookSources/978-1-62703-790-7"><bdi>978-1-62703-790-7</bdi></a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24470015">24470015</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+Ras+superfamily+of+small+GTPases%3A+the+unlocked+secrets.&rft.series=Methods+in+Molecular+Biology&rft.pages=1-18&rft.date=2013-12-26&rft_id=info%3Apmid%2F24470015&rft_id=info%3Adoi%2F10.1007%2F978-1-62703-791-4_1&rft.isbn=978-1-62703-790-7&rft.aulast=Goitre&rft.aufirst=L&rft.au=Trapani%2C+E&rft.au=Trabalzini%2C+L&rft.au=Retta%2C+SF&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARas+superfamily" class="Z3988"></span></span> </li> <li id="cite_note-Munemitsu-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-Munemitsu_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Munemitsu_3-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Munemitsu_3-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Munemitsu_3-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMunemitsuInnisClarkMcCormick1990" class="citation journal cs1">Munemitsu S, Innis M, Clark R, McCormick F, Ullrich A, Polakis P (1990). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC361395">"Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42"</a>. <i>Mol Cell Biol</i>. <b>10</b> (11): 5977–82. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FMCB.10.11.5977">10.1128/MCB.10.11.5977</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0270-7306">0270-7306</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC361395">361395</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2122236">2122236</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mol+Cell+Biol&rft.atitle=Molecular+cloning+and+expression+of+a+G25K+cDNA%2C+the+human+homolog+of+the+yeast+cell+cycle+gene+CDC42&rft.volume=10&rft.issue=11&rft.pages=5977-82&rft.date=1990&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC361395%23id-name%3DPMC&rft.issn=0270-7306&rft_id=info%3Apmid%2F2122236&rft_id=info%3Adoi%2F10.1128%2FMCB.10.11.5977&rft.aulast=Munemitsu&rft.aufirst=S&rft.au=Innis%2C+M&rft.au=Clark%2C+R&rft.au=McCormick%2C+F&rft.au=Ullrich%2C+A&rft.au=Polakis%2C+P&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC361395&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARas+superfamily" class="Z3988"></span></span> </li> </ol></div></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist 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navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Acid_anhydride_hydrolases" title="Template:Acid anhydride hydrolases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Acid_anhydride_hydrolases" title="Template talk:Acid anhydride hydrolases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Acid_anhydride_hydrolases" title="Special:EditPage/Template:Acid anhydride hydrolases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Hydrolases:_acid_anhydride_hydrolases_(EC_3.6)" style="font-size:114%;margin:0 4em"><a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a>: <a href="/wiki/Acid_anhydride_hydrolases" title="Acid anhydride hydrolases">acid anhydride hydrolases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 3.6)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.1" title="List of EC numbers (EC 3)">3.6.1</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pyrophosphatase" title="Pyrophosphatase">Pyrophosphatase</a> <ul><li><a href="/wiki/Inorganic_pyrophosphatase" title="Inorganic pyrophosphatase">Inorganic</a></li> <li><a href="/wiki/Thiamine_pyrophosphatase" class="mw-redirect" title="Thiamine pyrophosphatase">Thiamine</a></li></ul></li> <li><a href="/wiki/Apyrase" title="Apyrase">Apyrase</a></li> <li><a href="/wiki/Thiamine-triphosphatase" title="Thiamine-triphosphatase">Thiamine-triphosphatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.2" title="List of EC numbers (EC 3)">3.6.2</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenylylsulfatase" title="Adenylylsulfatase">Adenylylsulfatase</a></li> <li><a href="/wiki/Phosphoadenylylsulfatase" title="Phosphoadenylylsulfatase">Phosphoadenylylsulfatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.3" title="List of EC numbers (EC 3)">3.6.3</a>-<a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.4" title="List of EC numbers (EC 3)">4</a>: <a href="/wiki/ATPase" title="ATPase">ATPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">3.6.3</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Cu++ (3.6.3.4)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ATP7A" title="ATP7A">Menkes/ATP7A</a></li> <li><a href="/wiki/Wilson_disease_protein" title="Wilson disease protein">Wilson/ATP7B</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Calcium_ATPase" title="Calcium ATPase">Ca+</a> (3.6.3.8)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/SERCA" title="SERCA">SERCA</a> <ul><li><a href="/wiki/ATP2A1" title="ATP2A1">ATP2A1</a></li> <li><a href="/wiki/ATP2A2" title="ATP2A2">ATP2A2</a></li> <li><a href="/wiki/ATP2A3" title="ATP2A3">ATP2A3</a></li></ul></li> <li><a href="/wiki/Plasma_membrane_Ca2%2B_ATPase" title="Plasma membrane Ca2+ ATPase">Plasma membrane</a> <ul><li><a href="/wiki/ATP2B1" title="ATP2B1">ATP2B1</a></li> <li><a href="/wiki/ATP2B2" title="ATP2B2">ATP2B2</a></li> <li><a href="/wiki/ATP2B3" title="ATP2B3">ATP2B3</a></li> <li><a href="/wiki/ATP2B4" title="ATP2B4">ATP2B4</a></li></ul></li> <li><a href="/wiki/Secretory_Pathway_Ca%C2%B2%E2%81%BA_ATPase" title="Secretory Pathway Ca²⁺ ATPase">SPCA</a> <ul><li><a href="/wiki/ATP2C1" title="ATP2C1">ATP2C1</a></li> <li><a href="/w/index.php?title=ATP2C2&action=edit&redlink=1" class="new" title="ATP2C2 (page does not exist)">ATP2C2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Na%2B/K%2B-ATPase" class="mw-redirect" title="Na+/K+-ATPase">Na+/K+</a> (3.6.3.9)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ATPase,_Na%2B/K%2B_transporting,_alpha_1" title="ATPase, Na+/K+ transporting, alpha 1">ATP1A1</a></li> <li><a href="/wiki/ATP1A2" title="ATP1A2">ATP1A2</a></li> <li><a href="/wiki/ATP1A3" title="ATP1A3">ATP1A3</a></li> <li><a href="/wiki/ATP1A4" title="ATP1A4">ATP1A4</a></li> <li><a href="/wiki/ATP1B1" title="ATP1B1">ATP1B1</a></li> <li><a href="/w/index.php?title=ATP1B2&action=edit&redlink=1" class="new" title="ATP1B2 (page does not exist)">ATP1B2</a></li> <li><a href="/wiki/ATP1B3" title="ATP1B3">ATP1B3</a></li> <li><a href="/w/index.php?title=ATP1B4&action=edit&redlink=1" class="new" title="ATP1B4 (page does not exist)">ATP1B4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hydrogen_potassium_ATPase" title="Hydrogen potassium ATPase">H+/K+</a> (3.6.3.10)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=ATP4A&action=edit&redlink=1" class="new" title="ATP4A (page does not exist)">ATP4A</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other <a href="/wiki/P-type_ATPase" title="P-type ATPase">P-type ATPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ATP8B1" class="mw-redirect" title="ATP8B1">ATP8B1</a></li> <li><a href="/wiki/ATP10A" class="mw-redirect" title="ATP10A">ATP10A</a></li> <li><a href="/wiki/ATP11B" title="ATP11B">ATP11B</a></li> <li><a href="/wiki/ATP12A" title="ATP12A">ATP12A</a></li> <li><a href="/wiki/ATP13A2" title="ATP13A2">ATP13A2</a></li> <li><a href="/wiki/ATP13A3" title="ATP13A3">ATP13A3</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.4</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dynein" title="Dynein">Dynein</a></li> <li><a href="/wiki/Kinesin" title="Kinesin">Kinesin</a></li> <li><a href="/wiki/Myosin" title="Myosin">Myosin</a></li> <li><a href="/wiki/Katanin" title="Katanin">Katanin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.5" title="List of EC numbers (EC 3)">3.6.5</a>: <a href="/wiki/GTPase" title="GTPase">GTPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.1: <a href="/wiki/Heterotrimeric_G_protein" title="Heterotrimeric G protein">Heterotrimeric G protein</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Gs_alpha_subunit" title="Gs alpha subunit">G<sub>αs</sub></a> <ul><li><a href="/wiki/Olfactory_receptor" title="Olfactory receptor">G<sub>olf</sub></a></li></ul></li> <li><a href="/wiki/Gi_alpha_subunit" title="Gi alpha subunit">G<sub>αi</sub></a> <ul><li><a href="/wiki/GNAI1" title="GNAI1">GNAI1</a></li> <li><a href="/wiki/GNAI2" title="GNAI2">GNAI2</a></li> <li><a href="/wiki/GNAI3" title="GNAI3">GNAI3</a></li> <li><a href="/wiki/Transducin" title="Transducin">Transducin</a> <ul><li><a href="/wiki/GNAT1" title="GNAT1">GNAT1</a></li> <li><a href="/wiki/GNAT2" title="GNAT2">GNAT2</a></li></ul></li> <li><a href="/wiki/Gustducin" title="Gustducin">Gustducin</a> <ul><li><a href="/wiki/GNAT3" title="GNAT3">GNAT3</a></li></ul></li></ul></li> <li><a href="/wiki/Gq_alpha_subunit" title="Gq alpha subunit">G<sub>αq/11</sub></a> <ul><li><a href="/wiki/GNAQ" title="GNAQ">GNAQ</a></li> <li><a href="/wiki/GNA11" title="GNA11">GNA11</a></li></ul></li> <li><a href="/wiki/G12/G13_alpha_subunits" title="G12/G13 alpha subunits">G<sub>α12/13</sub></a> <ul><li><a href="/wiki/GNA12" title="GNA12">GNA12</a></li> <li><a href="/wiki/GNA13" title="GNA13">GNA13</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.2: <a href="/wiki/Small_GTPase" title="Small GTPase">Small GTPase</a> > <a class="mw-selflink selflink">Ras superfamily</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Rho_family_of_GTPases" title="Rho family of GTPases">Rho family of GTPases</a>: <i>Cdc42</i> <ul><li><a href="/wiki/CDC42" title="CDC42">CDC42</a></li> <li><a href="/wiki/TC10_protein" class="mw-redirect" title="TC10 protein">TC10</a></li> <li><a href="/wiki/TCL_(GTPase)" title="TCL (GTPase)">TCL</a></li></ul></li> <li><i>RhoUV</i> <ul><li><a href="/wiki/Wrch1" title="Wrch1">RhoU</a></li> <li><a href="/wiki/Chp_(GTPase)" title="Chp (GTPase)">RhoV</a></li></ul></li> <li><a href="/wiki/Rac_(GTPase)" title="Rac (GTPase)">Rac</a> <ul><li><a href="/wiki/RAC1" title="RAC1">Rac1</a></li> <li><a href="/wiki/RAC2" title="RAC2">2</a></li> <li><a href="/wiki/Rac3" class="mw-redirect" title="Rac3">3</a></li> <li><a href="/wiki/RhoG" title="RhoG">RhoG</a></li></ul></li> <li><i>RhoBTB</i> <ul><li><a href="/wiki/RHOBTB1" title="RHOBTB1">1</a></li> <li><a href="/wiki/RHOBTB2" title="RHOBTB2">2</a></li></ul></li> <li><a href="/wiki/RhoH" title="RhoH">RhoH</a></li> <li><a href="/wiki/Rho_family_of_GTPases" title="Rho family of GTPases">Rho</a> <ul><li><a href="/wiki/RHOA" class="mw-redirect" title="RHOA">A</a></li> <li><a href="/wiki/RHOB" title="RHOB">B</a></li> <li><a href="/wiki/RhoC" title="RhoC">C</a></li></ul></li> <li><a href="/wiki/Rnd_(GTPase)" title="Rnd (GTPase)">Rnd</a> <ul><li><a href="/wiki/Rnd1" title="Rnd1">1</a></li> <li><a href="/wiki/Rnd2" title="Rnd2">2</a></li> <li><a href="/wiki/Rnd3" title="Rnd3">3</a></li></ul></li> <li><i>RhoDF</i> <ul><li><a href="/wiki/Rif_(GTPase)" title="Rif (GTPase)">RhoF</a></li> <li><a href="/wiki/RhoD" title="RhoD">RhoD</a></li></ul></li></ul> <ul><li>other: <a href="/wiki/Ras_subfamily" class="mw-redirect" title="Ras subfamily">Ras</a> <ul><li><a href="/wiki/HRAS" title="HRAS">HRAS</a></li> <li><a href="/wiki/KRAS" title="KRAS">KRAS</a></li> <li><a href="/wiki/Neuroblastoma_RAS_viral_oncogene_homolog" title="Neuroblastoma RAS viral oncogene homolog">NRAS</a></li></ul></li> <li><a href="/wiki/Rab_(G-protein)" title="Rab (G-protein)">Rab</a> <ul><li><a href="/wiki/RAB23" title="RAB23">RAB23</a></li> <li><a href="/wiki/RAB27" title="RAB27">RAB27</a></li></ul></li> <li><a href="/wiki/ADP_ribosylation_factor" title="ADP ribosylation factor">Arf</a> <ul><li><a href="/wiki/ARF6" title="ARF6">ARF6</a></li> <li><a href="/wiki/SAR1B" class="mw-redirect" title="SAR1B">SAR1B</a></li> <li><a href="/wiki/ARL13B" title="ARL13B">ARL13B</a></li> <li><a href="/wiki/ARL6" title="ARL6">ARL6</a></li></ul></li> <li><a href="/wiki/Ran_(gene)" class="mw-redirect" title="Ran (gene)">Ran</a></li> <li><a href="/wiki/RHEB" title="RHEB">Rheb</a></li> <li><a href="/wiki/Rap_GTP-binding_protein" title="Rap GTP-binding protein">Rap</a></li> <li><a href="/wiki/RRAD_(gene)" title="RRAD (gene)">RGK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.3: <a href="/wiki/Protein-synthesizing_GTPase" title="Protein-synthesizing GTPase">Protein-synthesizing GTPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Prokaryotic_elongation_factors" class="mw-redirect" title="Prokaryotic elongation factors">Prokaryotic</a> <ul><li><a href="/wiki/Prokaryotic_initiation_factor-2" class="mw-redirect" title="Prokaryotic initiation factor-2">IF-2</a></li> <li><a href="/wiki/EF-Tu" title="EF-Tu">EF-Tu</a></li> <li><a href="/wiki/EF-G" title="EF-G">EF-G</a></li></ul></li> <li><a href="/wiki/Eukaryotic_elongation_factors" class="mw-redirect" title="Eukaryotic elongation factors">Eukaryotic</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.5-6: <a href="/wiki/Molecular_motor" title="Molecular motor">Polymerization motors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dynamin_superfamily" title="Dynamin superfamily">dynamin superfamily</a> <ul><li><a href="/wiki/Dynamin" title="Dynamin">Dynamin</a></li> <li><a href="/wiki/Guanylate-binding_protein" title="Guanylate-binding protein">Guanylate-binding protein</a></li> <li><a href="/w/index.php?title=Mitofusin-1&action=edit&redlink=1" class="new" title="Mitofusin-1 (page does not exist)">Mitofusin-1</a></li> <li><a href="/wiki/MX1" title="MX1">MX1</a> and <a href="/wiki/MX2" title="MX2">MX2</a></li> <li><a href="/wiki/Dynamin-like_120_kDa_protein" title="Dynamin-like 120 kDa protein">OPA1</a></li></ul></li> <li><a href="/wiki/Tubulin" title="Tubulin">Tubulin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this 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href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output 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