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<span>Structure</span> </div> </a> <ul id="toc-Structure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Role_in_cancer" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Role_in_cancer"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Role in cancer</span> </div> </a> <ul id="toc-Role_in_cancer-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Takenouchi-Kosaki_syndrome" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Takenouchi-Kosaki_syndrome"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Takenouchi-Kosaki syndrome</span> </div> </a> <ul id="toc-Takenouchi-Kosaki_syndrome-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Interactions" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Interactions</span> </div> </a> <ul id="toc-Interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> 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id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in humans</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">CDC42</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:CDC42.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/22/CDC42.png/250px-CDC42.png" decoding="async" width="250" height="188" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/22/CDC42.png/375px-CDC42.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/22/CDC42.png/500px-CDC42.png 2x" data-file-width="640" data-file-height="480" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P60766%20or%20P60953">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P60766,P60953">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4YDH">4YDH</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1A4R">1A4R</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1AJE">1AJE</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1AM4">1AM4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1AN0">1AN0</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1CEE">1CEE</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1CF4">1CF4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1DOA">1DOA</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1E0A">1E0A</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1EES">1EES</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1GRN">1GRN</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1GZS">1GZS</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1KI1">1KI1</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1KZ7">1KZ7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1KZG">1KZG</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1NF3">1NF3</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2ASE">2ASE</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2DFK">2DFK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2KB0">2KB0</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2NGR">2NGR</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2ODB">2ODB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2QRZ">2QRZ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2WM9">2WM9</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2WMN">2WMN</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2WMO">2WMO</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3GCG">3GCG</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3QBV">3QBV</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3VHL">3VHL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4DID">4DID</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4ITR">4ITR</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4JS0">4JS0</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4YC7">4YC7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5FI1">5FI1</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/1736">CDC42</a></span>, CDC42Hs, G25K, TKS, cell division cycle 42</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/116952">116952</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:106211">106211</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=123986">123986</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CDC42">CDC42</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000070831">CDC42 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_1.svg" class="mw-file-description" title="Chromosome 1 (human)"><img alt="Chromosome 1 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/450px-Ideogram_human_chromosome_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/600px-Ideogram_human_chromosome_1.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Chromosome_1_(human)" class="mw-redirect" title="Chromosome 1 (human)">Chromosome 1 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_1_ideogram.svg" class="mw-file-description" title="Chromosome 1 (human)"><img alt="Chromosome 1 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/300px-Human_chromosome_1_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/450px-Human_chromosome_1_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/600px-Human_chromosome_1_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 20.683186335857px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CDC42"><img alt="Genomic location for CDC42" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 26.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CDC42"><img alt="Genomic location for CDC42" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">1p36.12</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">22,052,627 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">22,101,360 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_4.svg" class="mw-file-description" title="Chromosome 4 (mouse)"><img alt="Chromosome 4 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/260px-Ideogram_house_mouse_chromosome_4.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/390px-Ideogram_house_mouse_chromosome_4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/520px-Ideogram_house_mouse_chromosome_4.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Chromosome 4 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_4.svg" class="mw-file-description" title="Chromosome 4 (mouse)"><img alt="Chromosome 4 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Ideogram_of_house_mouse_chromosome_4.svg/300px-Ideogram_of_house_mouse_chromosome_4.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Ideogram_of_house_mouse_chromosome_4.svg/450px-Ideogram_of_house_mouse_chromosome_4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Ideogram_of_house_mouse_chromosome_4.svg/600px-Ideogram_of_house_mouse_chromosome_4.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 252.70721322532px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CDC42"><img alt="Genomic location for CDC42" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 258.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CDC42"><img alt="Genomic location for CDC42" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">4 D3|4 69.83 cM</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">137,319,696 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">137,357,720 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000070831">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">monocyte</li><br /><li style="line-height: 137%;">islet of Langerhans</li><br /><li style="line-height: 137%;">rectum</li><br /><li style="line-height: 137%;">ganglionic eminence</li><br /><li style="line-height: 137%;">gallbladder</li><br /><li style="line-height: 137%;">epithelium of colon</li><br /><li style="line-height: 137%;">smooth muscle tissue</li><br /><li style="line-height: 137%;">olfactory zone of nasal mucosa</li><br /><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">ventricular zone</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000006699">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">ascending aorta</li><br /><li style="line-height: 137%;">aortic valve</li><br /><li style="line-height: 137%;">Epithelium of choroid plexus</li><br /><li style="line-height: 137%;">endothelial cell of lymphatic vessel</li><br /><li style="line-height: 137%;">stroma of bone marrow</li><br /><li style="line-height: 137%;">medullary collecting duct</li><br /><li style="line-height: 137%;">renal corpuscle</li><br /><li style="line-height: 137%;">molar</li><br /><li style="line-height: 137%;">vestibular sensory epithelium</li><br /><li style="line-height: 137%;">dermis</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000070831">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_CDC42_210232_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/ba/PBB_GE_CDC42_210232_at_fs.png/250px-PBB_GE_CDC42_210232_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/ba/PBB_GE_CDC42_210232_at_fs.png/375px-PBB_GE_CDC42_210232_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/ba/PBB_GE_CDC42_210232_at_fs.png/500px-PBB_GE_CDC42_210232_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_CDC42_208728_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/PBB_GE_CDC42_208728_s_at_fs.png/250px-PBB_GE_CDC42_208728_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/PBB_GE_CDC42_208728_s_at_fs.png/375px-PBB_GE_CDC42_208728_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0e/PBB_GE_CDC42_208728_s_at_fs.png/500px-PBB_GE_CDC42_208728_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_CDC42_208727_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/PBB_GE_CDC42_208727_s_at_fs.png/250px-PBB_GE_CDC42_208727_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/PBB_GE_CDC42_208727_s_at_fs.png/375px-PBB_GE_CDC42_208727_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/PBB_GE_CDC42_208727_s_at_fs.png/500px-PBB_GE_CDC42_208727_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/998/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051022">Rho GDP-dissociation inhibitor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0061630">ubiquitin protein ligase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034191">apolipoprotein A-I receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030742">GTP-dependent protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003924">GTPase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031435">mitogen-activated protein kinase kinase kinase binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031996">thioesterase binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019901">protein kinase binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000166">nucleotide binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005525">GTP binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042802">identical protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004674">protein serine/threonine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032427">GBD domain binding</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005911">cell-cell junction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005925">focal adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005815">microtubule organizing center</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051233">spindle midzone</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043005">neuron projection</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000322">storage vacuole</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005856">cytoskeleton</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042995">cell projection</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043209">myelin sheath</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070062">extracellular exosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030175">filopodium</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005819">spindle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045177">apical part of cell</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030141">secretory granule</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043025">soma</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0036464">cytoplasmic ribonucleoprotein granule</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072686">mitotic spindle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031256">leading edge membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071944">cell periphery</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005789">endoplasmic reticulum membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000139">Golgi membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030496">midbody</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005813">centrosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005938">cell cortex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0017119">Golgi transport complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032991">protein-containing complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043197">dendritic spine</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003161">cardiac conduction system development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001934">positive regulation of protein phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042059">negative regulation of epidermal growth factor receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051149">positive regulation of muscle cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007097">nuclear migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031424">keratinization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046330">positive regulation of JNK cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051683">establishment of Golgi localization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051017">actin filament bundle assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043525">positive regulation of neuron apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048010">vascular endothelial growth factor receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031069">hair follicle morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060047">heart contraction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031647">regulation of protein stability</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048664">neuron fate determination</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0021762">substantia nigra development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038096">Fc-gamma receptor signaling pathway involved in phagocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007015">actin filament organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031333">negative regulation of protein-containing complex assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060684">epithelial-mesenchymal cell signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0090135">actin filament branching</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010629">negative regulation of gene expression</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033138">positive regulation of peptidyl-serine phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007163">establishment or maintenance of cell polarity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030307">positive regulation of cell growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051246">regulation of protein metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035088">establishment or maintenance of apical/basal cell polarity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045859">regulation of protein kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051988">regulation of attachment of spindle microtubules to kinetochore</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051056">regulation of small GTPase mediated signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071338">positive regulation of hair follicle cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043410">positive regulation of MAPK cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007088">regulation of mitotic nuclear division</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060789">hair follicle placode formation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0090316">positive regulation of intracellular protein transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030154">cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060501">positive regulation of epithelial cell proliferation involved in lung morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043497">regulation of protein heterodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007030">Golgi organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051835">positive regulation of synapse structural plasticity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035264">multicellular organism growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048730">epidermis morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051647">nucleus localization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0090136">epithelial cell-cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002040">sprouting angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007399">nervous system development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030225">macrophage differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0036336">dendritic cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032467">positive regulation of cytokinesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045740">positive regulation of DNA replication</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060071">Wnt signaling pathway, planar cell polarity pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003334">keratinocyte development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042176">regulation of protein catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060070">canonical Wnt signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034332">adherens junction organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072384">organelle transport along microtubule</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030036">actin cytoskeleton organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051489">regulation of filopodium assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006897">endocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048013">ephrin receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046847">filopodium assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031295">T cell costimulation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007596">blood coagulation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043552">positive regulation of phosphatidylinositol 3-kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1900026">positive regulation of substrate adhesion-dependent cell spreading</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010628">positive regulation of gene expression</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031274">positive regulation of pseudopodium assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060661">submandibular salivary gland formation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0039694">viral RNA genome replication</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007264">small GTPase mediated signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016567">protein ubiquitination</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043085">positive regulation of catalytic activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006468">protein phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006911">phagocytosis, engulfment</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007229">integrin-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007266">Rho protein signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008360">regulation of cell shape</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010591">regulation of lamellipodium assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010592">positive regulation of lamellipodium assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030031">cell projection assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032488">Cdc42 protein signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032956">regulation of actin cytoskeleton organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034329">cell junction assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035722">interleukin-12-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038189">neuropilin signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045198">establishment of epithelial cell apical/basal polarity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051491">positive regulation of filopodium assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051492">regulation of stress fiber assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051496">positive regulation of stress fiber assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060997">dendritic spine morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0099563">modification of synaptic structure</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000251">positive regulation of actin cytoskeleton reorganization</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=998&rn=1">998</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=12540&rn=1">12540</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000070831;db=core">ENSG00000070831</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000006699;db=core">ENSMUSG00000006699</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P60953">P60953</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P60766">P60766</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_044472">NM_044472</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001039802">NM_001039802</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001791">NM_001791</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001243769">NM_001243769</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_009861">NM_009861</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001034891">NP_001034891</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001782">NP_001782</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_426359">NP_426359</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001230698">NP_001230698</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_033991">NP_033991</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr1:22052627-22101360">Chr 1: 22.05 – 22.1 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr4:137319696-137357720">Chr 4: 137.32 – 137.36 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q15311701" class="extiw" title="d:Q15311701">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q15311702" class="extiw" title="d:Q15311702">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Cell division control protein 42 homolog</b> (Cdc42 or CDC42) is a protein that in humans is encoded by the <i><b>CDC42</b></i> gene. Cdc42 is involved in regulation of the <a href="/wiki/Cell_cycle" title="Cell cycle">cell cycle</a>. It was originally identified in <a href="/wiki/Saccharomyces_cerevisiae" title="Saccharomyces cerevisiae"><i>S. cerevisiae</i></a> (yeast) as a mediator of <a href="/wiki/Cell_division" title="Cell division">cell division</a>,<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CDC42&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Human Cdc42 is a small <a href="/wiki/GTPase" title="GTPase">GTPase</a> of the <a href="/wiki/Rho_family_of_GTPases" title="Rho family of GTPases">Rho family</a>, which regulates signaling pathways that control diverse cellular functions including cell <a href="/wiki/Morphology_(biology)" title="Morphology (biology)">morphology</a>, <a href="/wiki/Cell_migration" title="Cell migration">cell migration</a>, <a href="/wiki/Endocytosis" title="Endocytosis">endocytosis</a>, <a href="/wiki/Cell_polarity" title="Cell polarity">cell polarity</a> and cell cycle progression.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Rho GTPases are central to dynamic actin cytoskeletal assembly and rearrangement that are the basis of cell-cell adhesion and migration. Activated Cdc42 activates by causing conformational changes<sup id="cite_ref-pmid10816416_8-0" class="reference"><a href="#cite_note-pmid10816416-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> in p21-activated kinases <a href="/wiki/PAK1" title="PAK1">PAK1</a> and <a href="/wiki/PAK2" title="PAK2">PAK2</a>, which in turn initiate actin reorganization and regulate cell adhesion, migration, and invasion.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CDC42&action=edit&section=2" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Cdc42 is a <a href="/wiki/Homodimer" class="mw-redirect" title="Homodimer">homodimer</a> with A and B chains.<sup id="cite_ref-PDBe_1a4r_10-0" class="reference"><a href="#cite_note-PDBe_1a4r-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Its total length is 191 amino acids and its theoretical weight is 21.33 kDa.<sup id="cite_ref-PDBe_1a4r_10-1" class="reference"><a href="#cite_note-PDBe_1a4r-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Its sequence domains include a P-loop containing nucleoside triphosphate hydrolase and a small GTP-binding protein domain.<sup id="cite_ref-PDBe_1a4r_10-2" class="reference"><a href="#cite_note-PDBe_1a4r-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Cdc42 cycles between an active GTP-bound state and an inactive GDP-bound state. This process is regulated by <a href="/wiki/Guanine_nucleotide_exchange_factor" title="Guanine nucleotide exchange factor">guanine nucleotide exchange factors</a> (GEFs) which promote the exchange of bound GDP for free GTP, <a href="/wiki/GTPase_activating_protein" class="mw-redirect" title="GTPase activating protein">GTPase activating proteins</a> (GAPs) which increase GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Role_in_cancer">Role in cancer</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CDC42&action=edit&section=3" title="Edit section: Role in cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Recently, Cdc42 has been shown to actively assist in cancer progression. Several studies have established the basis for this and hypothesized about the underlying mechanisms. </p><p>Cdc42 is overexpressed in non-small cell lung cancer, colorectal adenocarcinoma, melanoma, breast cancer, and testicular cancer.<sup id="cite_ref-Stengel_2011_12-0" class="reference"><a href="#cite_note-Stengel_2011-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Elevated levels of the protein have been correlated with negative patient survival. Cdc42 has also been shown to be required for both G1-S phase progression and mitosis, and it also modulates the transcription factors SRF, STAT3, and NFkB.<sup id="cite_ref-Stengel_2011_12-1" class="reference"><a href="#cite_note-Stengel_2011-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> It has been hypothesized that targeting Cdc42 in conjunction with chemotherapy may be an effective cancer treatment strategy. </p><p>In one study studying the role of Cdc42 in cervical cancer, <a href="/wiki/Immunohistochemistry" title="Immunohistochemistry">immunohistochemistry</a> was used to detect Cdc42 expression in three types of tissues: normal cervical tissues, <a href="/wiki/Cervical_intraepithelial_neoplasia" title="Cervical intraepithelial neoplasia">cervical intraepithelial neoplasia</a> (CIN) I or below, CIN II or above, and cervical cancer tissues.<sup id="cite_ref-Ye_2015_13-0" class="reference"><a href="#cite_note-Ye_2015-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Cdc42 expression was gradually increased showing significant difference and was significantly higher in <a href="/wiki/HeLa" title="HeLa">HeLa</a> cells than in regular cells. The migration ability of HeLa cells transfected with Cdc42 was higher than that of non-transfected cells.<sup id="cite_ref-Ye_2015_13-1" class="reference"><a href="#cite_note-Ye_2015-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> It was proposed that the overexpression of Cdc42 can promote <a href="/wiki/Filopodia" title="Filopodia">filopodia</a> formation in HeLa cells. Cdc42 overexpression significantly improved the ability of cervical cancer cells to migrate, possibly due to improved <a href="/wiki/Pseudopodia" title="Pseudopodia">pseudopodia</a> formation.<sup id="cite_ref-Ye_2015_13-2" class="reference"><a href="#cite_note-Ye_2015-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p>Another study found that Cdc42 drives the process of initiating a <a href="/wiki/Metastasis" title="Metastasis">metastatic</a> tumor in a new tissue by promoting the expression of β1 <a href="/wiki/Integrin" title="Integrin">integrin</a>, an adhesion receptor known to be involved in metastasis.<sup id="cite_ref-Wilson_1987_14-0" class="reference"><a href="#cite_note-Wilson_1987-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Levels of β1 integrin were reduced in Cdc42-deficient cells. β1 integrin is important for adhesion to the <a href="/wiki/Extracellular_matrix" title="Extracellular matrix">extracellular matrix</a>, and could be important for the initial attachment to endothelial cells as well. Knocking down β1 integrin inhibited cancer cell migration, whereas overexpressing the integrin in Cdc42-deficient cells restored <a href="/wiki/Endothelium" title="Endothelium">endothelial</a> invasion.<sup id="cite_ref-Wilson_1987_14-1" class="reference"><a href="#cite_note-Wilson_1987-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Cdc42 promoted β1 integrin expression by activating a transcription factor called SRF. A continually active form of the transcription factor was also capable of restoring endothelial insertion to cancer cells lacking Cdc42. </p><p>Normal cancer cells and Cdc42-deficient cancer cells have also been compared in vivo. When both types of cells were injected into mouse tail veins, control cells spread out more on the vessel endothelium within minutes, suggesting that Cdc42 assists in cell migration.<sup id="cite_ref-Wilson_1987_14-2" class="reference"><a href="#cite_note-Wilson_1987-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> After six weeks, the control cells had generated more metastases than the Cdc42-deficient cells. Invading cancer cells send out protrusions that reach down between neighboring endothelial cells to contact the underlying basement membrane. The cancer cells then spread out on this extracellular matrix so that the endothelial cells retract, and allow the invaders to insert themselves between them.<sup id="cite_ref-Wilson_1987_14-3" class="reference"><a href="#cite_note-Wilson_1987-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> In the absence of Cdc42, cancer cells failed to spread out on the basement membrane, and Cdc42-deficient cells showed reduced adhesion to extracellular matrix-coated coverslips.<sup id="cite_ref-Wilson_1987_14-4" class="reference"><a href="#cite_note-Wilson_1987-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Cdc42 therefore promotes the attachment of cancer cells to both endothelial cells and the underlying basement membrane during transendothelial migration. </p><p>The small molecular inhibitor AZA197 has been used to inhibit Cdc42 in the treatment of KRAS mutant colorectal cancers.<sup id="cite_ref-Zins_2013_15-0" class="reference"><a href="#cite_note-Zins_2013-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> There was evidence that Cdc42 inhibition by AZA197 treatment suppresses proliferative and pro-survival signaling pathways via PAK1-ERK signaling and reduces colon cancer cell migration and invasion.<sup id="cite_ref-Zins_2013_15-1" class="reference"><a href="#cite_note-Zins_2013-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> In mice, systemic AZA197 treatment in vivo reduced primary tumor growth and prolonged survival.<sup id="cite_ref-Zins_2013_15-2" class="reference"><a href="#cite_note-Zins_2013-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Therapy targeting Rho GTPase Cdc42 signaling pathways may be effective for treatment of patients with advanced colon cancer overexpressing Cdc42, and particularly those with KRAS-mutant disease. </p> <div class="mw-heading mw-heading2"><h2 id="Takenouchi-Kosaki_syndrome">Takenouchi-Kosaki syndrome</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CDC42&action=edit&section=4" title="Edit section: Takenouchi-Kosaki syndrome"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Mutations in the <i>CDC42</i> gene are responsible for the <a href="/w/index.php?title=Takenouchi-Kosaki_syndrome&action=edit&redlink=1" class="new" title="Takenouchi-Kosaki syndrome (page does not exist)">Takenouchi-Kosaki syndrome</a>, an <a href="/wiki/Dominance_(genetics)" title="Dominance (genetics)">autosomal-dominant</a> complex congenital developmental disorder associated with <a href="/wiki/Thrombocytopenia" title="Thrombocytopenia">thrombocytopenia</a>.<sup id="cite_ref-Santoro_2021_16-0" class="reference"><a href="#cite_note-Santoro_2021-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> Alleic variants that are associated with the syndrome include mutations in the <i>CDC42</i> gene that are expressed at the protein level as Ile21Thr, Tyr64Cys, Arg66Gly, Cys81Phe, Ser83Pro, or Glu171Lys.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CDC42&action=edit&section=5" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>CDC42 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/ARHGAP1" title="ARHGAP1">ARHGAP1</a>,<sup id="cite_ref-pmid9427749_18-0" class="reference"><a href="#cite_note-pmid9427749-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9407060_19-0" class="reference"><a href="#cite_note-pmid9407060-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10551883_20-0" class="reference"><a href="#cite_note-pmid10551883-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9535855_21-0" class="reference"><a href="#cite_note-pmid9535855-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/ARHGDIA" title="ARHGDIA">ARHGDIA</a>,<sup id="cite_ref-pmid17353931_22-0" class="reference"><a href="#cite_note-pmid17353931-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9490022_23-0" class="reference"><a href="#cite_note-pmid9490022-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/BAIAP2" title="BAIAP2">BAIAP2</a>,<sup id="cite_ref-pmid12504591_24-0" class="reference"><a href="#cite_note-pmid12504591-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11696321_25-0" class="reference"><a href="#cite_note-pmid11696321-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11130076_26-0" class="reference"><a href="#cite_note-pmid11130076-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/BNIP2" title="BNIP2">BNIP2</a>,<sup id="cite_ref-pmid10551883_20-1" class="reference"><a href="#cite_note-pmid10551883-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10799524_27-0" class="reference"><a href="#cite_note-pmid10799524-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10954711_28-0" class="reference"><a href="#cite_note-pmid10954711-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/BNIPL" title="BNIPL">BNIPL</a>,<sup id="cite_ref-pmid12901880_29-0" class="reference"><a href="#cite_note-pmid12901880-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CDC42EP2" title="CDC42EP2">CDC42EP2</a>,<sup id="cite_ref-pmid10490598_30-0" class="reference"><a href="#cite_note-pmid10490598-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11035016_31-0" class="reference"><a href="#cite_note-pmid11035016-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CDC42EP3" title="CDC42EP3">CDC42EP3</a>,<sup id="cite_ref-pmid10490598_30-1" class="reference"><a href="#cite_note-pmid10490598-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9535835_32-0" class="reference"><a href="#cite_note-pmid9535835-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/ERRFI1" title="ERRFI1">ERRFI1</a>,<sup id="cite_ref-pmid10749885_33-0" class="reference"><a href="#cite_note-pmid10749885-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/GDI1" title="GDI1">GDI1</a>,<sup id="cite_ref-pmid11583574_34-0" class="reference"><a href="#cite_note-pmid11583574-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/IQGAP1" title="IQGAP1">IQGAP1</a>,<sup id="cite_ref-pmid9535855_21-1" class="reference"><a href="#cite_note-pmid9535855-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8798539_35-0" class="reference"><a href="#cite_note-pmid8798539-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12110184_36-0" class="reference"><a href="#cite_note-pmid12110184-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8670801_37-0" class="reference"><a href="#cite_note-pmid8670801-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9182573_38-0" class="reference"><a href="#cite_note-pmid9182573-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/IQGAP2" title="IQGAP2">IQGAP2</a>,<sup id="cite_ref-pmid8756646_39-0" class="reference"><a href="#cite_note-pmid8756646-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/ITSN1" class="mw-redirect" title="ITSN1">ITSN1</a>,<sup id="cite_ref-pmid11584276_40-0" class="reference"><a href="#cite_note-pmid11584276-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12006984_41-0" class="reference"><a href="#cite_note-pmid12006984-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MAP3K10" title="MAP3K10">MAP3K10</a>,<sup id="cite_ref-pmid9427749_18-1" class="reference"><a href="#cite_note-pmid9427749-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MAP3K11" title="MAP3K11">MAP3K11</a>,<sup id="cite_ref-pmid9427749_18-2" class="reference"><a href="#cite_note-pmid9427749-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10799501_42-0" class="reference"><a href="#cite_note-pmid10799501-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PAK1" title="PAK1">PAK1</a>,<sup id="cite_ref-pmid9535855_21-2" class="reference"><a href="#cite_note-pmid9535855-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12650940_43-0" class="reference"><a href="#cite_note-pmid12650940-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PAK2" title="PAK2">PAK2</a>,<sup id="cite_ref-pmid9535855_21-3" class="reference"><a href="#cite_note-pmid9535855-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10320322_44-0" class="reference"><a href="#cite_note-pmid10320322-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9822598_45-0" class="reference"><a href="#cite_note-pmid9822598-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PAK4" title="PAK4">PAK4</a>.<sup id="cite_ref-pmid17353931_22-1" class="reference"><a href="#cite_note-pmid17353931-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9822598_45-1" class="reference"><a href="#cite_note-pmid9822598-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11756552_46-0" class="reference"><a href="#cite_note-pmid11756552-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PAK7" class="mw-redirect" title="PAK7">PAK7</a>,<sup id="cite_ref-pmid11756552_46-1" class="reference"><a href="#cite_note-pmid11756552-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12032833_47-0" class="reference"><a href="#cite_note-pmid12032833-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PARD6A" title="PARD6A">PARD6A</a>,<sup id="cite_ref-pmid10934474_48-0" class="reference"><a href="#cite_note-pmid10934474-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11260256_49-0" class="reference"><a href="#cite_note-pmid11260256-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10873802_50-0" class="reference"><a href="#cite_note-pmid10873802-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PARD6B" title="PARD6B">PARD6B</a>,<sup id="cite_ref-pmid10934474_48-1" class="reference"><a href="#cite_note-pmid10934474-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11260256_49-1" class="reference"><a href="#cite_note-pmid11260256-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11162552_51-0" class="reference"><a href="#cite_note-pmid11162552-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Phospholipase_D1" title="Phospholipase D1">Phospholipase D1</a>,<sup id="cite_ref-pmid10747870_52-0" class="reference"><a href="#cite_note-pmid10747870-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/RICS_(gene)" title="RICS (gene)">RICS</a><sup id="cite_ref-pmid12857875_53-0" class="reference"><a href="#cite_note-pmid12857875-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12819203_54-0" class="reference"><a href="#cite_note-pmid12819203-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12446789_55-0" class="reference"><a href="#cite_note-pmid12446789-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/TRIP10" title="TRIP10">TRIP10</a>,<sup id="cite_ref-pmid9210375_56-0" class="reference"><a href="#cite_note-pmid9210375-56"><span class="cite-bracket">[</span>56<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10713100_57-0" class="reference"><a href="#cite_note-pmid10713100-57"><span class="cite-bracket">[</span>57<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/WASL_(gene)" title="WASL (gene)">WASL</a>,<sup id="cite_ref-pmid10781580_58-0" class="reference"><a href="#cite_note-pmid10781580-58"><span class="cite-bracket">[</span>58<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9422512_59-0" class="reference"><a href="#cite_note-pmid9422512-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Wiskott%E2%80%93Aldrich_syndrome_protein" title="Wiskott–Aldrich syndrome protein">Wiskott–Aldrich syndrome protein</a>,<sup id="cite_ref-pmid10713100_57-1" class="reference"><a href="#cite_note-pmid10713100-57"><span class="cite-bracket">[</span>57<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10724160_60-0" class="reference"><a href="#cite_note-pmid10724160-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8643625_61-0" class="reference"><a href="#cite_note-pmid8643625-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8625410_62-0" class="reference"><a href="#cite_note-pmid8625410-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CDC42&action=edit&section=6" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/ROP_GTPase" title="ROP GTPase">ROP GTPase</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CDC42&action=edit&section=7" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 33em;"> <ol class="references"> <li 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href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000006699">GRCm38: Ensembl release 89: ENSMUSG00000006699</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output 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style="width:100%;padding:0"><div style="padding:0 0.25em"><ul class="gallery mw-gallery-traditional nochecker" style="line-height:130%"> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1a4r_EBI.jpg" class="mw-file-description" title="1a4r: G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM"><img alt="1a4r: G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/21/PDB_1a4r_EBI.jpg/180px-PDB_1a4r_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/21/PDB_1a4r_EBI.jpg/270px-PDB_1a4r_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/21/PDB_1a4r_EBI.jpg/360px-PDB_1a4r_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1a4r</b>: G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1aje_EBI.jpg" class="mw-file-description" title="1aje: CDC42 FROM HUMAN, NMR, 20 STRUCTURES"><img alt="1aje: CDC42 FROM HUMAN, NMR, 20 STRUCTURES" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/de/PDB_1aje_EBI.jpg/180px-PDB_1aje_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/de/PDB_1aje_EBI.jpg/270px-PDB_1aje_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/de/PDB_1aje_EBI.jpg/360px-PDB_1aje_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1aje</b>: CDC42 FROM HUMAN, NMR, 20 STRUCTURES</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1am4_EBI.jpg" 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src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/PDB_1doa_EBI.jpg/180px-PDB_1doa_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/PDB_1doa_EBI.jpg/270px-PDB_1doa_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7f/PDB_1doa_EBI.jpg/360px-PDB_1doa_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1doa</b>: STRUCTURE OF THE RHO FAMILY GTP-BINDING PROTEIN CDC42 IN COMPLEX WITH THE MULTIFUNCTIONAL REGULATOR RHOGDI</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1e0a_EBI.jpg" class="mw-file-description" title="1e0a: CDC42 COMPLEXED WITH THE GTPASE BINDING DOMAIN OF P21 ACTIVATED KINASE"><img alt="1e0a: CDC42 COMPLEXED WITH THE GTPASE BINDING DOMAIN OF P21 ACTIVATED KINASE" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4b/PDB_1e0a_EBI.jpg/180px-PDB_1e0a_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4b/PDB_1e0a_EBI.jpg/270px-PDB_1e0a_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4b/PDB_1e0a_EBI.jpg/360px-PDB_1e0a_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1e0a</b>: CDC42 COMPLEXED WITH THE GTPASE BINDING DOMAIN OF P21 ACTIVATED KINASE</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1ees_EBI.jpg" class="mw-file-description" title="1ees: SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES"><img alt="1ees: SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/89/PDB_1ees_EBI.jpg/180px-PDB_1ees_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/89/PDB_1ees_EBI.jpg/270px-PDB_1ees_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/89/PDB_1ees_EBI.jpg/360px-PDB_1ees_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1ees</b>: SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1grn_EBI.jpg" class="mw-file-description" title="1grn: CRYSTAL STRUCTURE OF THE CDC42/CDC42GAP/ALF3 COMPLEX."><img alt="1grn: CRYSTAL STRUCTURE OF THE CDC42/CDC42GAP/ALF3 COMPLEX." src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d3/PDB_1grn_EBI.jpg/180px-PDB_1grn_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d3/PDB_1grn_EBI.jpg/270px-PDB_1grn_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d3/PDB_1grn_EBI.jpg/360px-PDB_1grn_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1grn</b>: CRYSTAL STRUCTURE OF THE CDC42/CDC42GAP/ALF3 COMPLEX.</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1gzs_EBI.jpg" class="mw-file-description" title="1gzs: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE GEF DOMAIN OF THE SALMONELLA TYPHIMURIUM SOPE TOXIN AND HUMAN CDC42"><img alt="1gzs: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE GEF DOMAIN OF THE SALMONELLA TYPHIMURIUM SOPE TOXIN AND HUMAN CDC42" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/19/PDB_1gzs_EBI.jpg/180px-PDB_1gzs_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/19/PDB_1gzs_EBI.jpg/270px-PDB_1gzs_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/19/PDB_1gzs_EBI.jpg/360px-PDB_1gzs_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1gzs</b>: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE GEF DOMAIN OF THE SALMONELLA TYPHIMURIUM SOPE TOXIN AND HUMAN CDC42</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1ki1_EBI.jpg" class="mw-file-description" title="1ki1: Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42"><img alt="1ki1: Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c8/PDB_1ki1_EBI.jpg/180px-PDB_1ki1_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c8/PDB_1ki1_EBI.jpg/270px-PDB_1ki1_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c8/PDB_1ki1_EBI.jpg/360px-PDB_1ki1_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1ki1</b>: Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1kz7_EBI.jpg" class="mw-file-description" title="1kz7: Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42"><img alt="1kz7: Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/PDB_1kz7_EBI.jpg/180px-PDB_1kz7_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/PDB_1kz7_EBI.jpg/270px-PDB_1kz7_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d5/PDB_1kz7_EBI.jpg/360px-PDB_1kz7_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1kz7</b>: Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1kzg_EBI.jpg" class="mw-file-description" title="1kzg: DbsCdc42(Y889F)"><img alt="1kzg: DbsCdc42(Y889F)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/60/PDB_1kzg_EBI.jpg/180px-PDB_1kzg_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/60/PDB_1kzg_EBI.jpg/270px-PDB_1kzg_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/60/PDB_1kzg_EBI.jpg/360px-PDB_1kzg_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1kzg</b>: DbsCdc42(Y889F)</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1nf3_EBI.jpg" class="mw-file-description" title="1nf3: Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6"><img alt="1nf3: Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8f/PDB_1nf3_EBI.jpg/180px-PDB_1nf3_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8f/PDB_1nf3_EBI.jpg/270px-PDB_1nf3_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8f/PDB_1nf3_EBI.jpg/360px-PDB_1nf3_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1nf3</b>: Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2ase_EBI.jpg" class="mw-file-description" title="2ase: NMR structure of the F28L mutant of Cdc42Hs"><img alt="2ase: NMR structure of the F28L mutant of Cdc42Hs" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/PDB_2ase_EBI.jpg/180px-PDB_2ase_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/PDB_2ase_EBI.jpg/270px-PDB_2ase_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ae/PDB_2ase_EBI.jpg/360px-PDB_2ase_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2ase</b>: NMR structure of the F28L mutant of Cdc42Hs</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2dfk_EBI.jpg" class="mw-file-description" title="2dfk: Crystal structure of the CDC42-Collybistin II complex"><img alt="2dfk: Crystal structure of the CDC42-Collybistin II complex" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/76/PDB_2dfk_EBI.jpg/180px-PDB_2dfk_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/76/PDB_2dfk_EBI.jpg/270px-PDB_2dfk_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/76/PDB_2dfk_EBI.jpg/360px-PDB_2dfk_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2dfk</b>: Crystal structure of the CDC42-Collybistin II complex</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2ngr_EBI.jpg" class="mw-file-description" title="2ngr: TRANSITION STATE COMPLEX FOR GTP HYDROLYSIS BY CDC42: COMPARISONS OF THE HIGH RESOLUTION STRUCTURES FOR CDC42 BOUND TO THE ACTIVE AND CATALYTICALLY COMPROMISED FORMS OF THE CDC42-GAP."><img alt="2ngr: TRANSITION STATE COMPLEX FOR GTP HYDROLYSIS BY CDC42: COMPARISONS OF THE HIGH RESOLUTION STRUCTURES FOR CDC42 BOUND TO THE ACTIVE AND CATALYTICALLY COMPROMISED FORMS OF THE CDC42-GAP." src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0f/PDB_2ngr_EBI.jpg/180px-PDB_2ngr_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0f/PDB_2ngr_EBI.jpg/270px-PDB_2ngr_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0f/PDB_2ngr_EBI.jpg/360px-PDB_2ngr_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2ngr</b>: TRANSITION STATE COMPLEX FOR GTP HYDROLYSIS BY CDC42: COMPARISONS OF THE HIGH RESOLUTION STRUCTURES FOR CDC42 BOUND TO THE ACTIVE AND CATALYTICALLY COMPROMISED FORMS OF THE CDC42-GAP.</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2odb_EBI.png" class="mw-file-description" title="2odb: The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)"><img alt="2odb: The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/PDB_2odb_EBI.png/180px-PDB_2odb_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/PDB_2odb_EBI.png/270px-PDB_2odb_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/61/PDB_2odb_EBI.png/360px-PDB_2odb_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2odb</b>: The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Hydrolases:_acid_anhydride_hydrolases_(EC_3.6)310" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Acid_anhydride_hydrolases" title="Template:Acid anhydride hydrolases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Acid_anhydride_hydrolases" title="Template talk:Acid anhydride hydrolases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Acid_anhydride_hydrolases" title="Special:EditPage/Template:Acid anhydride hydrolases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Hydrolases:_acid_anhydride_hydrolases_(EC_3.6)310" style="font-size:114%;margin:0 4em"><a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a>: <a href="/wiki/Acid_anhydride_hydrolases" title="Acid anhydride hydrolases">acid anhydride hydrolases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 3.6)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.1" title="List of EC numbers (EC 3)">3.6.1</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pyrophosphatase" title="Pyrophosphatase">Pyrophosphatase</a> <ul><li><a href="/wiki/Inorganic_pyrophosphatase" title="Inorganic pyrophosphatase">Inorganic</a></li> <li><a href="/wiki/Thiamine_pyrophosphatase" class="mw-redirect" title="Thiamine pyrophosphatase">Thiamine</a></li></ul></li> <li><a href="/wiki/Apyrase" title="Apyrase">Apyrase</a></li> <li><a href="/wiki/Thiamine-triphosphatase" title="Thiamine-triphosphatase">Thiamine-triphosphatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.2" title="List of EC numbers (EC 3)">3.6.2</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenylylsulfatase" title="Adenylylsulfatase">Adenylylsulfatase</a></li> <li><a href="/wiki/Phosphoadenylylsulfatase" title="Phosphoadenylylsulfatase">Phosphoadenylylsulfatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.3" title="List of EC numbers (EC 3)">3.6.3</a>-<a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.4" title="List of EC numbers (EC 3)">4</a>: <a href="/wiki/ATPase" title="ATPase">ATPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">3.6.3</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Cu++ (3.6.3.4)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ATP7A" title="ATP7A">Menkes/ATP7A</a></li> <li><a href="/wiki/Wilson_disease_protein" title="Wilson disease protein">Wilson/ATP7B</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Calcium_ATPase" title="Calcium ATPase">Ca+</a> (3.6.3.8)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/SERCA" title="SERCA">SERCA</a> <ul><li><a href="/wiki/ATP2A1" title="ATP2A1">ATP2A1</a></li> <li><a href="/wiki/ATP2A2" title="ATP2A2">ATP2A2</a></li> <li><a href="/wiki/ATP2A3" title="ATP2A3">ATP2A3</a></li></ul></li> <li><a href="/wiki/Plasma_membrane_Ca2%2B_ATPase" title="Plasma membrane Ca2+ ATPase">Plasma membrane</a> <ul><li><a href="/wiki/ATP2B1" title="ATP2B1">ATP2B1</a></li> <li><a href="/wiki/ATP2B2" title="ATP2B2">ATP2B2</a></li> <li><a href="/wiki/ATP2B3" title="ATP2B3">ATP2B3</a></li> <li><a href="/wiki/ATP2B4" title="ATP2B4">ATP2B4</a></li></ul></li> <li><a href="/wiki/Secretory_Pathway_Ca%C2%B2%E2%81%BA_ATPase" title="Secretory Pathway Ca²⁺ ATPase">SPCA</a> <ul><li><a href="/wiki/ATP2C1" title="ATP2C1">ATP2C1</a></li> <li><a href="/w/index.php?title=ATP2C2&action=edit&redlink=1" class="new" title="ATP2C2 (page does not exist)">ATP2C2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Na%2B/K%2B-ATPase" class="mw-redirect" title="Na+/K+-ATPase">Na+/K+</a> (3.6.3.9)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ATPase,_Na%2B/K%2B_transporting,_alpha_1" title="ATPase, Na+/K+ transporting, alpha 1">ATP1A1</a></li> <li><a href="/wiki/ATP1A2" title="ATP1A2">ATP1A2</a></li> <li><a href="/wiki/ATP1A3" title="ATP1A3">ATP1A3</a></li> <li><a href="/wiki/ATP1A4" title="ATP1A4">ATP1A4</a></li> <li><a href="/wiki/ATP1B1" title="ATP1B1">ATP1B1</a></li> <li><a href="/w/index.php?title=ATP1B2&action=edit&redlink=1" class="new" title="ATP1B2 (page does not exist)">ATP1B2</a></li> <li><a href="/wiki/ATP1B3" title="ATP1B3">ATP1B3</a></li> <li><a href="/w/index.php?title=ATP1B4&action=edit&redlink=1" class="new" title="ATP1B4 (page does not exist)">ATP1B4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hydrogen_potassium_ATPase" title="Hydrogen potassium ATPase">H+/K+</a> (3.6.3.10)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=ATP4A&action=edit&redlink=1" class="new" title="ATP4A (page does not exist)">ATP4A</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other <a href="/wiki/P-type_ATPase" title="P-type ATPase">P-type ATPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ATP8B1" class="mw-redirect" title="ATP8B1">ATP8B1</a></li> <li><a href="/wiki/ATP10A" class="mw-redirect" title="ATP10A">ATP10A</a></li> <li><a href="/wiki/ATP11B" title="ATP11B">ATP11B</a></li> <li><a href="/wiki/ATP12A" title="ATP12A">ATP12A</a></li> <li><a href="/wiki/ATP13A2" title="ATP13A2">ATP13A2</a></li> <li><a href="/wiki/ATP13A3" title="ATP13A3">ATP13A3</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.4</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dynein" title="Dynein">Dynein</a></li> <li><a href="/wiki/Kinesin" title="Kinesin">Kinesin</a></li> <li><a href="/wiki/Myosin" title="Myosin">Myosin</a></li> <li><a href="/wiki/Katanin" title="Katanin">Katanin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.5" title="List of EC numbers (EC 3)">3.6.5</a>: <a href="/wiki/GTPase" title="GTPase">GTPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.1: <a href="/wiki/Heterotrimeric_G_protein" title="Heterotrimeric G protein">Heterotrimeric G protein</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Gs_alpha_subunit" title="Gs alpha subunit">G<sub>αs</sub></a> <ul><li><a href="/wiki/Olfactory_receptor" title="Olfactory receptor">G<sub>olf</sub></a></li></ul></li> <li><a href="/wiki/Gi_alpha_subunit" title="Gi alpha subunit">G<sub>αi</sub></a> <ul><li><a href="/wiki/GNAI1" title="GNAI1">GNAI1</a></li> <li><a href="/wiki/GNAI2" title="GNAI2">GNAI2</a></li> <li><a href="/wiki/GNAI3" title="GNAI3">GNAI3</a></li> <li><a href="/wiki/Transducin" title="Transducin">Transducin</a> <ul><li><a href="/wiki/GNAT1" title="GNAT1">GNAT1</a></li> <li><a href="/wiki/GNAT2" title="GNAT2">GNAT2</a></li></ul></li> <li><a href="/wiki/Gustducin" title="Gustducin">Gustducin</a> <ul><li><a href="/wiki/GNAT3" title="GNAT3">GNAT3</a></li></ul></li></ul></li> <li><a href="/wiki/Gq_alpha_subunit" title="Gq alpha subunit">G<sub>αq/11</sub></a> <ul><li><a href="/wiki/GNAQ" title="GNAQ">GNAQ</a></li> <li><a href="/wiki/GNA11" title="GNA11">GNA11</a></li></ul></li> <li><a href="/wiki/G12/G13_alpha_subunits" title="G12/G13 alpha subunits">G<sub>α12/13</sub></a> <ul><li><a href="/wiki/GNA12" title="GNA12">GNA12</a></li> <li><a href="/wiki/GNA13" title="GNA13">GNA13</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.2: <a href="/wiki/Small_GTPase" title="Small GTPase">Small GTPase</a> > <a href="/wiki/Ras_superfamily" title="Ras superfamily">Ras superfamily</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Rho_family_of_GTPases" title="Rho family of GTPases">Rho family of GTPases</a>: <i>Cdc42</i> <ul><li><a class="mw-selflink selflink">CDC42</a></li> <li><a href="/wiki/TC10_protein" class="mw-redirect" title="TC10 protein">TC10</a></li> <li><a href="/wiki/TCL_(GTPase)" title="TCL (GTPase)">TCL</a></li></ul></li> <li><i>RhoUV</i> <ul><li><a href="/wiki/Wrch1" title="Wrch1">RhoU</a></li> <li><a href="/wiki/Chp_(GTPase)" title="Chp (GTPase)">RhoV</a></li></ul></li> <li><a href="/wiki/Rac_(GTPase)" title="Rac (GTPase)">Rac</a> <ul><li><a href="/wiki/RAC1" title="RAC1">Rac1</a></li> <li><a href="/wiki/RAC2" title="RAC2">2</a></li> <li><a href="/wiki/Rac3" class="mw-redirect" title="Rac3">3</a></li> <li><a href="/wiki/RhoG" title="RhoG">RhoG</a></li></ul></li> <li><i>RhoBTB</i> <ul><li><a href="/wiki/RHOBTB1" title="RHOBTB1">1</a></li> <li><a href="/wiki/RHOBTB2" title="RHOBTB2">2</a></li></ul></li> <li><a href="/wiki/RhoH" title="RhoH">RhoH</a></li> <li><a href="/wiki/Rho_family_of_GTPases" title="Rho family of GTPases">Rho</a> <ul><li><a href="/wiki/RHOA" class="mw-redirect" title="RHOA">A</a></li> <li><a href="/wiki/RHOB" title="RHOB">B</a></li> <li><a href="/wiki/RhoC" title="RhoC">C</a></li></ul></li> <li><a href="/wiki/Rnd_(GTPase)" title="Rnd (GTPase)">Rnd</a> <ul><li><a href="/wiki/Rnd1" title="Rnd1">1</a></li> <li><a href="/wiki/Rnd2" title="Rnd2">2</a></li> <li><a href="/wiki/Rnd3" title="Rnd3">3</a></li></ul></li> <li><i>RhoDF</i> <ul><li><a href="/wiki/Rif_(GTPase)" title="Rif (GTPase)">RhoF</a></li> <li><a href="/wiki/RhoD" title="RhoD">RhoD</a></li></ul></li></ul> <ul><li>other: <a href="/wiki/Ras_subfamily" class="mw-redirect" title="Ras subfamily">Ras</a> <ul><li><a href="/wiki/HRAS" title="HRAS">HRAS</a></li> <li><a href="/wiki/KRAS" title="KRAS">KRAS</a></li> <li><a href="/wiki/Neuroblastoma_RAS_viral_oncogene_homolog" title="Neuroblastoma RAS viral oncogene homolog">NRAS</a></li></ul></li> <li><a href="/wiki/Rab_(G-protein)" title="Rab (G-protein)">Rab</a> <ul><li><a href="/wiki/RAB23" title="RAB23">RAB23</a></li> <li><a href="/wiki/RAB27" title="RAB27">RAB27</a></li></ul></li> <li><a href="/wiki/ADP_ribosylation_factor" title="ADP ribosylation factor">Arf</a> <ul><li><a href="/wiki/ARF6" title="ARF6">ARF6</a></li> <li><a href="/wiki/SAR1B" class="mw-redirect" title="SAR1B">SAR1B</a></li> <li><a href="/wiki/ARL13B" title="ARL13B">ARL13B</a></li> <li><a href="/wiki/ARL6" title="ARL6">ARL6</a></li></ul></li> <li><a href="/wiki/Ran_(gene)" class="mw-redirect" title="Ran (gene)">Ran</a></li> <li><a href="/wiki/RHEB" title="RHEB">Rheb</a></li> <li><a href="/wiki/Rap_GTP-binding_protein" title="Rap GTP-binding protein">Rap</a></li> <li><a href="/wiki/RRAD_(gene)" title="RRAD (gene)">RGK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.3: <a href="/wiki/Protein-synthesizing_GTPase" title="Protein-synthesizing GTPase">Protein-synthesizing GTPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Prokaryotic_elongation_factors" class="mw-redirect" title="Prokaryotic elongation factors">Prokaryotic</a> <ul><li><a href="/wiki/Prokaryotic_initiation_factor-2" class="mw-redirect" title="Prokaryotic initiation factor-2">IF-2</a></li> <li><a href="/wiki/EF-Tu" title="EF-Tu">EF-Tu</a></li> <li><a href="/wiki/EF-G" title="EF-G">EF-G</a></li></ul></li> <li><a href="/wiki/Eukaryotic_elongation_factors" class="mw-redirect" title="Eukaryotic elongation factors">Eukaryotic</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.5-6: <a href="/wiki/Molecular_motor" title="Molecular motor">Polymerization motors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dynamin_superfamily" title="Dynamin superfamily">dynamin superfamily</a> <ul><li><a href="/wiki/Dynamin" title="Dynamin">Dynamin</a></li> <li><a href="/wiki/Guanylate-binding_protein" title="Guanylate-binding protein">Guanylate-binding protein</a></li> <li><a href="/w/index.php?title=Mitofusin-1&action=edit&redlink=1" class="new" title="Mitofusin-1 (page does not exist)">Mitofusin-1</a></li> <li><a href="/wiki/MX1" title="MX1">MX1</a> and <a href="/wiki/MX2" title="MX2">MX2</a></li> <li><a href="/wiki/Dynamin-like_120_kDa_protein" title="Dynamin-like 120 kDa protein">OPA1</a></li></ul></li> <li><a href="/wiki/Tubulin" title="Tubulin">Tubulin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Cell_cycle_proteins179" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cell_cycle_proteins" title="Template:Cell cycle proteins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cell_cycle_proteins" title="Template talk:Cell cycle proteins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cell_cycle_proteins" title="Special:EditPage/Template:Cell cycle proteins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cell_cycle_proteins179" style="font-size:114%;margin:0 4em"><a href="/wiki/Cell_cycle" title="Cell cycle">Cell cycle</a> <a href="/wiki/Protein" title="Protein">proteins</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cyclin" title="Cyclin">Cyclin</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cyclin_A" title="Cyclin A">A</a> (<a href="/wiki/Cyclin_A1" title="Cyclin A1">A1</a>, <a href="/wiki/Cyclin_A2" title="Cyclin A2">A2</a>)</li> <li><a href="/wiki/Cyclin_B" title="Cyclin B">B</a> (<a href="/wiki/Cyclin_B1" title="Cyclin B1">B1</a>, <a href="/wiki/Cyclin_B2" title="Cyclin B2">B2</a>, B3)</li> <li><a href="/wiki/Cyclin_D" title="Cyclin D">D</a> (<a href="/wiki/Cyclin_D1" title="Cyclin D1">D1</a>, <a href="/wiki/Cyclin_D2" title="Cyclin D2">D2</a>, <a href="/wiki/Cyclin_D3" title="Cyclin D3">D3</a>)</li> <li><a href="/wiki/Cyclin_E" title="Cyclin E">E</a> (<a href="/wiki/Cyclin_E1" title="Cyclin E1">E1</a>, <a href="/wiki/Cyclin_E2" title="Cyclin E2">E2</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cyclin-dependent_kinase" title="Cyclin-dependent kinase">CDK</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cyclin-dependent_kinase_1" title="Cyclin-dependent kinase 1">1</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_2" title="Cyclin-dependent kinase 2">2</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_3" title="Cyclin-dependent kinase 3">3</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_4" title="Cyclin-dependent kinase 4">4</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_5" title="Cyclin-dependent kinase 5">5</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_6" title="Cyclin-dependent kinase 6">6</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_7" title="Cyclin-dependent kinase 7">7</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_8" title="Cyclin-dependent kinase 8">8</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_9" title="Cyclin-dependent kinase 9">9</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_10" title="Cyclin-dependent kinase 10">10</a></li> <li><a href="/wiki/CDC2L2" title="CDC2L2">11A</a></li> <li><a href="/wiki/CDC2L1" title="CDC2L1">11B</a></li> <li><a href="/wiki/CDK12" title="CDK12">12</a></li> <li><a href="/wiki/CDK13" title="CDK13">13</a></li> <li><a href="/wiki/PFTK1" title="PFTK1">14</a></li> <li><a href="/wiki/CDK-activating_kinase" title="CDK-activating kinase">CDK-activating kinase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cyclin-dependent_kinase_inhibitor_protein" title="Cyclin-dependent kinase inhibitor protein">CDK inhibitor</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/INK4" title="INK4">INK4a/ARF</a> (<a href="/wiki/P14arf" title="P14arf">p14arf</a>/<a href="/wiki/P16" title="P16">p16</a>, <a href="/wiki/CDKN2B" title="CDKN2B">p15</a>, <a href="/wiki/CDKN2C" title="CDKN2C">p18</a>, <a href="/wiki/CDKN2D" title="CDKN2D">p19</a>)</li> <li><a href="/wiki/Cell_cycle#Inhibitors" title="Cell cycle">cip/kip</a> (<a href="/wiki/P21" title="P21">p21</a>, <a href="/wiki/CDKN1B" title="CDKN1B">p27</a>, <a href="/wiki/Cyclin-dependent_kinase_inhibitor_1C" title="Cyclin-dependent kinase inhibitor 1C">p57</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/P53_p63_p73_family" title="P53 p63 p73 family">P53 p63 p73 family</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/P53" title="P53">p53</a></li> <li><a href="/wiki/TP63" title="TP63">p63</a></li> <li><a href="/wiki/P73" title="P73">p73</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cdk1" class="mw-redirect" title="Cdk1">Cdc2</a></li> <li><a href="/wiki/Cdc25" title="Cdc25">Cdc25</a></li> <li><a class="mw-selflink selflink">Cdc42</a></li> <li><a href="/wiki/Cellular_apoptosis_susceptibility_protein" title="Cellular apoptosis susceptibility protein">Cellular apoptosis susceptibility protein</a></li> <li><a href="/wiki/E2F" title="E2F">E2F</a></li> <li><a href="/wiki/Maturation_promoting_factor" title="Maturation promoting factor">Maturation promoting factor</a></li> <li><a href="/wiki/Wee1" title="Wee1">Wee</a></li> <li><a href="/wiki/Cullin" title="Cullin">Cullin</a> (<a href="/wiki/CUL7" title="CUL7">CUL7</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Phases and<br />checkpoints</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interphase" title="Interphase">Interphase</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/G1_phase" title="G1 phase">G<sub>1</sub> phase</a></li> <li><a href="/wiki/S_phase" title="S phase">S phase</a></li> <li><a href="/wiki/G2_phase" title="G2 phase">G<sub>2</sub> phase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_division" title="Cell division">M phase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mitosis" title="Mitosis">Mitosis</a> (<a href="/wiki/Preprophase" title="Preprophase">Preprophase</a></li> <li><a href="/wiki/Prophase" title="Prophase">Prophase</a></li> <li><a href="/wiki/Prometaphase" title="Prometaphase">Prometaphase</a></li> <li><a href="/wiki/Metaphase" title="Metaphase">Metaphase</a></li> <li><a href="/wiki/Anaphase" title="Anaphase">Anaphase</a></li> <li><a href="/wiki/Telophase" title="Telophase">Telophase</a>)</li> <li><a href="/wiki/Cytokinesis" title="Cytokinesis">Cytokinesis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_cycle_checkpoint" title="Cell cycle checkpoint">Cell cycle checkpoints</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Restriction_point" title="Restriction point">Restriction point</a></li> <li><a href="/wiki/Spindle_checkpoint" title="Spindle checkpoint">Spindle checkpoint</a></li> <li><a href="/wiki/Postreplication_checkpoint" title="Postreplication checkpoint">Postreplication checkpoint</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other cellular phases</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Apoptosis" title="Apoptosis">Apoptosis</a></li> <li><a href="/wiki/G0_phase" title="G0 phase">G<sub>0</sub> phase</a></li> <li><a href="/wiki/Meiosis" title="Meiosis">Meiosis</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Hydrolases:_acid_anhydride_hydrolases_(EC_3.6)310" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Acid_anhydride_hydrolases" title="Template:Acid anhydride hydrolases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Acid_anhydride_hydrolases" title="Template talk:Acid anhydride hydrolases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Acid_anhydride_hydrolases" title="Special:EditPage/Template:Acid anhydride hydrolases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Hydrolases:_acid_anhydride_hydrolases_(EC_3.6)310" style="font-size:114%;margin:0 4em"><a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a>: <a href="/wiki/Acid_anhydride_hydrolases" title="Acid anhydride hydrolases">acid anhydride hydrolases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 3.6)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.1" title="List of EC numbers (EC 3)">3.6.1</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pyrophosphatase" title="Pyrophosphatase">Pyrophosphatase</a> <ul><li><a href="/wiki/Inorganic_pyrophosphatase" title="Inorganic pyrophosphatase">Inorganic</a></li> <li><a href="/wiki/Thiamine_pyrophosphatase" class="mw-redirect" title="Thiamine pyrophosphatase">Thiamine</a></li></ul></li> <li><a href="/wiki/Apyrase" title="Apyrase">Apyrase</a></li> <li><a href="/wiki/Thiamine-triphosphatase" title="Thiamine-triphosphatase">Thiamine-triphosphatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.2" title="List of EC numbers (EC 3)">3.6.2</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenylylsulfatase" title="Adenylylsulfatase">Adenylylsulfatase</a></li> <li><a href="/wiki/Phosphoadenylylsulfatase" title="Phosphoadenylylsulfatase">Phosphoadenylylsulfatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.3" title="List of EC numbers (EC 3)">3.6.3</a>-<a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.4" title="List of EC numbers (EC 3)">4</a>: <a href="/wiki/ATPase" title="ATPase">ATPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">3.6.3</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Cu++ (3.6.3.4)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ATP7A" title="ATP7A">Menkes/ATP7A</a></li> <li><a href="/wiki/Wilson_disease_protein" title="Wilson disease protein">Wilson/ATP7B</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Calcium_ATPase" title="Calcium ATPase">Ca+</a> (3.6.3.8)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/SERCA" title="SERCA">SERCA</a> <ul><li><a href="/wiki/ATP2A1" title="ATP2A1">ATP2A1</a></li> <li><a href="/wiki/ATP2A2" title="ATP2A2">ATP2A2</a></li> <li><a href="/wiki/ATP2A3" title="ATP2A3">ATP2A3</a></li></ul></li> <li><a href="/wiki/Plasma_membrane_Ca2%2B_ATPase" title="Plasma membrane Ca2+ ATPase">Plasma membrane</a> <ul><li><a href="/wiki/ATP2B1" title="ATP2B1">ATP2B1</a></li> <li><a href="/wiki/ATP2B2" title="ATP2B2">ATP2B2</a></li> <li><a href="/wiki/ATP2B3" title="ATP2B3">ATP2B3</a></li> <li><a href="/wiki/ATP2B4" title="ATP2B4">ATP2B4</a></li></ul></li> <li><a href="/wiki/Secretory_Pathway_Ca%C2%B2%E2%81%BA_ATPase" title="Secretory Pathway Ca²⁺ ATPase">SPCA</a> <ul><li><a href="/wiki/ATP2C1" title="ATP2C1">ATP2C1</a></li> <li><a href="/w/index.php?title=ATP2C2&action=edit&redlink=1" class="new" title="ATP2C2 (page does not exist)">ATP2C2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Na%2B/K%2B-ATPase" class="mw-redirect" title="Na+/K+-ATPase">Na+/K+</a> (3.6.3.9)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ATPase,_Na%2B/K%2B_transporting,_alpha_1" title="ATPase, Na+/K+ transporting, alpha 1">ATP1A1</a></li> <li><a href="/wiki/ATP1A2" title="ATP1A2">ATP1A2</a></li> <li><a href="/wiki/ATP1A3" title="ATP1A3">ATP1A3</a></li> <li><a href="/wiki/ATP1A4" title="ATP1A4">ATP1A4</a></li> <li><a href="/wiki/ATP1B1" title="ATP1B1">ATP1B1</a></li> <li><a href="/w/index.php?title=ATP1B2&action=edit&redlink=1" class="new" title="ATP1B2 (page does not exist)">ATP1B2</a></li> <li><a href="/wiki/ATP1B3" title="ATP1B3">ATP1B3</a></li> <li><a href="/w/index.php?title=ATP1B4&action=edit&redlink=1" class="new" title="ATP1B4 (page does not exist)">ATP1B4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hydrogen_potassium_ATPase" title="Hydrogen potassium ATPase">H+/K+</a> (3.6.3.10)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=ATP4A&action=edit&redlink=1" class="new" title="ATP4A (page does not exist)">ATP4A</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other <a href="/wiki/P-type_ATPase" title="P-type ATPase">P-type ATPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ATP8B1" class="mw-redirect" title="ATP8B1">ATP8B1</a></li> <li><a href="/wiki/ATP10A" class="mw-redirect" title="ATP10A">ATP10A</a></li> <li><a href="/wiki/ATP11B" title="ATP11B">ATP11B</a></li> <li><a href="/wiki/ATP12A" title="ATP12A">ATP12A</a></li> <li><a href="/wiki/ATP13A2" title="ATP13A2">ATP13A2</a></li> <li><a href="/wiki/ATP13A3" title="ATP13A3">ATP13A3</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.4</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dynein" title="Dynein">Dynein</a></li> <li><a href="/wiki/Kinesin" title="Kinesin">Kinesin</a></li> <li><a href="/wiki/Myosin" title="Myosin">Myosin</a></li> <li><a href="/wiki/Katanin" title="Katanin">Katanin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#3.6.5" title="List of EC numbers (EC 3)">3.6.5</a>: <a href="/wiki/GTPase" title="GTPase">GTPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.1: <a href="/wiki/Heterotrimeric_G_protein" title="Heterotrimeric G protein">Heterotrimeric G protein</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Gs_alpha_subunit" title="Gs alpha subunit">G<sub>αs</sub></a> <ul><li><a href="/wiki/Olfactory_receptor" title="Olfactory receptor">G<sub>olf</sub></a></li></ul></li> <li><a href="/wiki/Gi_alpha_subunit" title="Gi alpha subunit">G<sub>αi</sub></a> <ul><li><a href="/wiki/GNAI1" title="GNAI1">GNAI1</a></li> <li><a href="/wiki/GNAI2" title="GNAI2">GNAI2</a></li> <li><a href="/wiki/GNAI3" title="GNAI3">GNAI3</a></li> <li><a href="/wiki/Transducin" title="Transducin">Transducin</a> <ul><li><a href="/wiki/GNAT1" title="GNAT1">GNAT1</a></li> <li><a href="/wiki/GNAT2" title="GNAT2">GNAT2</a></li></ul></li> <li><a href="/wiki/Gustducin" title="Gustducin">Gustducin</a> <ul><li><a href="/wiki/GNAT3" title="GNAT3">GNAT3</a></li></ul></li></ul></li> <li><a href="/wiki/Gq_alpha_subunit" title="Gq alpha subunit">G<sub>αq/11</sub></a> <ul><li><a href="/wiki/GNAQ" title="GNAQ">GNAQ</a></li> <li><a href="/wiki/GNA11" title="GNA11">GNA11</a></li></ul></li> <li><a href="/wiki/G12/G13_alpha_subunits" title="G12/G13 alpha subunits">G<sub>α12/13</sub></a> <ul><li><a href="/wiki/GNA12" title="GNA12">GNA12</a></li> <li><a href="/wiki/GNA13" title="GNA13">GNA13</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.2: <a href="/wiki/Small_GTPase" title="Small GTPase">Small GTPase</a> > <a href="/wiki/Ras_superfamily" title="Ras superfamily">Ras superfamily</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Rho_family_of_GTPases" title="Rho family of GTPases">Rho family of GTPases</a>: <i>Cdc42</i> <ul><li><a class="mw-selflink selflink">CDC42</a></li> <li><a href="/wiki/TC10_protein" class="mw-redirect" title="TC10 protein">TC10</a></li> <li><a href="/wiki/TCL_(GTPase)" title="TCL (GTPase)">TCL</a></li></ul></li> <li><i>RhoUV</i> <ul><li><a href="/wiki/Wrch1" title="Wrch1">RhoU</a></li> <li><a href="/wiki/Chp_(GTPase)" title="Chp (GTPase)">RhoV</a></li></ul></li> <li><a href="/wiki/Rac_(GTPase)" title="Rac (GTPase)">Rac</a> <ul><li><a href="/wiki/RAC1" title="RAC1">Rac1</a></li> <li><a href="/wiki/RAC2" title="RAC2">2</a></li> <li><a href="/wiki/Rac3" class="mw-redirect" title="Rac3">3</a></li> <li><a href="/wiki/RhoG" title="RhoG">RhoG</a></li></ul></li> <li><i>RhoBTB</i> <ul><li><a href="/wiki/RHOBTB1" title="RHOBTB1">1</a></li> <li><a href="/wiki/RHOBTB2" title="RHOBTB2">2</a></li></ul></li> <li><a href="/wiki/RhoH" title="RhoH">RhoH</a></li> <li><a href="/wiki/Rho_family_of_GTPases" title="Rho family of GTPases">Rho</a> <ul><li><a href="/wiki/RHOA" class="mw-redirect" title="RHOA">A</a></li> <li><a href="/wiki/RHOB" title="RHOB">B</a></li> <li><a href="/wiki/RhoC" title="RhoC">C</a></li></ul></li> <li><a href="/wiki/Rnd_(GTPase)" title="Rnd (GTPase)">Rnd</a> <ul><li><a href="/wiki/Rnd1" title="Rnd1">1</a></li> <li><a href="/wiki/Rnd2" title="Rnd2">2</a></li> <li><a href="/wiki/Rnd3" title="Rnd3">3</a></li></ul></li> <li><i>RhoDF</i> <ul><li><a href="/wiki/Rif_(GTPase)" title="Rif (GTPase)">RhoF</a></li> <li><a href="/wiki/RhoD" title="RhoD">RhoD</a></li></ul></li></ul> <ul><li>other: <a href="/wiki/Ras_subfamily" class="mw-redirect" title="Ras subfamily">Ras</a> <ul><li><a href="/wiki/HRAS" title="HRAS">HRAS</a></li> <li><a href="/wiki/KRAS" title="KRAS">KRAS</a></li> <li><a href="/wiki/Neuroblastoma_RAS_viral_oncogene_homolog" title="Neuroblastoma RAS viral oncogene homolog">NRAS</a></li></ul></li> <li><a href="/wiki/Rab_(G-protein)" title="Rab (G-protein)">Rab</a> <ul><li><a href="/wiki/RAB23" title="RAB23">RAB23</a></li> <li><a href="/wiki/RAB27" title="RAB27">RAB27</a></li></ul></li> <li><a href="/wiki/ADP_ribosylation_factor" title="ADP ribosylation factor">Arf</a> <ul><li><a href="/wiki/ARF6" title="ARF6">ARF6</a></li> <li><a href="/wiki/SAR1B" class="mw-redirect" title="SAR1B">SAR1B</a></li> <li><a href="/wiki/ARL13B" title="ARL13B">ARL13B</a></li> <li><a href="/wiki/ARL6" title="ARL6">ARL6</a></li></ul></li> <li><a href="/wiki/Ran_(gene)" class="mw-redirect" title="Ran (gene)">Ran</a></li> <li><a href="/wiki/RHEB" title="RHEB">Rheb</a></li> <li><a href="/wiki/Rap_GTP-binding_protein" title="Rap GTP-binding protein">Rap</a></li> <li><a href="/wiki/RRAD_(gene)" title="RRAD (gene)">RGK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.3: <a href="/wiki/Protein-synthesizing_GTPase" title="Protein-synthesizing GTPase">Protein-synthesizing GTPase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Prokaryotic_elongation_factors" class="mw-redirect" title="Prokaryotic elongation factors">Prokaryotic</a> <ul><li><a href="/wiki/Prokaryotic_initiation_factor-2" class="mw-redirect" title="Prokaryotic initiation factor-2">IF-2</a></li> <li><a href="/wiki/EF-Tu" title="EF-Tu">EF-Tu</a></li> <li><a href="/wiki/EF-G" title="EF-G">EF-G</a></li></ul></li> <li><a href="/wiki/Eukaryotic_elongation_factors" class="mw-redirect" title="Eukaryotic elongation factors">Eukaryotic</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3.6.5.5-6: <a href="/wiki/Molecular_motor" title="Molecular motor">Polymerization motors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dynamin_superfamily" title="Dynamin superfamily">dynamin superfamily</a> <ul><li><a href="/wiki/Dynamin" title="Dynamin">Dynamin</a></li> <li><a href="/wiki/Guanylate-binding_protein" title="Guanylate-binding protein">Guanylate-binding protein</a></li> <li><a href="/w/index.php?title=Mitofusin-1&action=edit&redlink=1" class="new" title="Mitofusin-1 (page does not exist)">Mitofusin-1</a></li> <li><a href="/wiki/MX1" title="MX1">MX1</a> and 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