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pertussis vaccine: controlled studies of immunogenicity and reactogenicity</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="35037977" href="https://usfca.academia.edu/MaryDarcy"><img alt="Profile image of Mary Darcy" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Mary Darcy</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2001, Vaccine</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">11 pages</p></div><div 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data-landing_url="https://www.academia.edu/15859663/A_combined_liquid_Hib_PRP_OMPC_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_controlled_studies_of_immunogenicity_and_reactogenicity" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="15859662" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15859662/A_combined_liquid_Hib_PRP_OMP_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_uncontrolled_preliminary_clinical_trial_of_immunogenicity_and_reactogenicity">A combined liquid Hib (PRP-OMP), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: uncontrolled preliminary clinical trial of immunogenicity and reactogenicity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35037977" href="https://usfca.academia.edu/MaryDarcy">Mary Darcy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A combined liquid Hib (PRP-OMP), hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine: uncontrolled preliminary clinical trial of immunogenicity and 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data-collection-position="1" data-entity-id="99497823" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants">Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given Along With Commercial Hib Vaccines inComparison With Separate Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="176086834" href="https://independent.academia.edu/ZeppFred">Fred Zepp</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pediatrics, 2002</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective. Combination vaccines simplify vaccine administration and have the potential to promote compliance and cost-effectiveness by decreasing the number of injections needed to immunize a child. The objective of this study was to assess the safety and reactogenicity of the diphtheria-tetanus toxoid-acellular pertussis-hepatitis B virus-inactivated polio virus (DTPa-HBV-IPV) vaccine when coadministered with different Haemophilus influenzae type B (Hib) vaccines in comparison with separate, commercially available, control vaccines in a 3-dose primary vaccination series. Methods. An open-label, randomized, parallel-group study in 5318 infants who were 8 to 16 weeks of age at enrollment was conducted in 90 centers in Germany. The incidence of adverse events that occurred in infants who received the DTPa-HBV-IPV candidate vaccine coadministered with 1 of 4 different Hib vaccines (given in separate sites; groups 1–4) was compared with the incidence that occurred in infants who receive...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given Along With Commercial Hib Vaccines inComparison With Separate Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants","attachmentId":100570559,"attachmentType":"pdf","work_url":"https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="96170416" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/96170416/Safety_and_immunogenicity_of_three_different_formulations_of_a_liquid_hexavalent_diphtheria_tetanus_acellular_pertussis_inactivated_poliovirus_Haemophilus_influenzae_b_conjugate_hepatitis_B_vaccine_at_2_4_6_and_12_14_months_of_age">Safety and immunogenicity of three different formulations of a liquid hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine at 2, 4, 6 and 12-14 months of age</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="7113918" href="https://independent.academia.edu/FranciscoDiaz9">Francisco Diaz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">The current recommended infant vaccination schedules require many injections at multiple sites, which increase stress for infants and parents and may create challenges to vaccination compliance. Therefore, combination vaccines, which reduce the number of injections at each medical visit, can be an essential method to improve compliance. The objective of this study was to assess the safety and immunogenicity of an investigational, liquid, hexavalent, pediatric vaccine at 2, 4, 6, and 12-14 months of age. In this multicenter, open-label controlled study, 756 infants were randomized in approximately equal numbers to receive 0.5mL intramuscular dose of diptheria-tetanus-pertussis-polio-Haemophilus influenzae type b+hepatitis B vaccine, or 1 of 3 double-blind investigational formulations. All formulations included a hepatitis B surface antigen (HBsAg) concentration of 10μg/0.5mL. 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href="https://www.academia.edu/17527248/Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given">Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants Along With Commercial Hib Vaccines inComparison With Separate Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37298606" href="https://unimedizin-mainz.academia.edu/ClaudiusMeyer">Claudius Meyer</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants Along With Commercial Hib Vaccines inComparison With Separate Safety and 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="16795810" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16795810/Comparison_of_the_reactogenicity_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_DTPa_HBV_IPV_vaccine_mixed_with_the_Haemophilus_influenzae_type_b_Hib_conjugate_vaccine_and_administered_as_a_single_injection_with_the_DTPa_IPV_Hib_and_">Comparison of the reactogenicity and immunogenicity of a combined diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio (DTPa–HBV–IPV) vaccine, mixed with the Haemophilus influenzae type b (Hib) conjugate vaccine and administered as a single injection, with the DTPa–IPV/Hib and...</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="26641596" href="https://independent.academia.edu/EugeniodeFrutos">Eugenio de Frutos</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36236693" href="https://independent.academia.edu/JosepMar%C3%A9s">Josep Marés</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Comparison of the reactogenicity and immunogenicity of a combined diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio (DTPa–HBV–IPV) vaccine, mixed with the Haemophilus influenzae type b (Hib) conjugate vaccine and administered as a single injection, with the DTPa–IPV/Hib and...","attachmentId":39187356,"attachmentType":"pdf","work_url":"https://www.academia.edu/16795810/Comparison_of_the_reactogenicity_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_DTPa_HBV_IPV_vaccine_mixed_with_the_Haemophilus_influenzae_type_b_Hib_conjugate_vaccine_and_administered_as_a_single_injection_with_the_DTPa_IPV_Hib_and_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/16795810/Comparison_of_the_reactogenicity_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_DTPa_HBV_IPV_vaccine_mixed_with_the_Haemophilus_influenzae_type_b_Hib_conjugate_vaccine_and_administered_as_a_single_injection_with_the_DTPa_IPV_Hib_and_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="14493062" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14493062/Safety_and_Immunogenicity_of_a_New_Fully_Liquid_DTPw_HepB_Hib_Combination_Vaccine_in_Infants">Safety and Immunogenicity of a New Fully Liquid DTPw-HepB-Hib Combination Vaccine in Infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33440598" href="https://hacettepe.academia.edu/AtesKara">Ates Kara</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and Immunogenicity of a New Fully Liquid DTPw-HepB-Hib Combination Vaccine in Infants","attachmentId":44114348,"attachmentType":"pdf","work_url":"https://www.academia.edu/14493062/Safety_and_Immunogenicity_of_a_New_Fully_Liquid_DTPw_HepB_Hib_Combination_Vaccine_in_Infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14493062/Safety_and_Immunogenicity_of_a_New_Fully_Liquid_DTPw_HepB_Hib_Combination_Vaccine_in_Infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="16980685" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16980685/Immunogenicity_and_safety_of_a_DTaP_IPV_PRP_approximately_T_combination_vaccine_given_with_hepatitis_B_vaccine_a_randomized_open_label_trial">Immunogenicity and safety of a DTaP-IPV//PRP approximately T combination vaccine given with hepatitis B vaccine: a randomized open-label trial</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36500531" href="https://independent.academia.edu/MariaCapeding">Maria Capeding</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Bulletin of the World Health Organization, 2008</p><p class="ds-related-work--abstract ds2-5-body-sm">To determine seroprotection and vaccine response rates produced by a diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type-b conjugate (DTaP-IPV//PRP approximately T) vaccine containing a polyribosyl-ribitol-phosphate (PRP)-tetanus toxoid conjugate (Pentaxim) and given with a hepatitis B vaccine. In this multicentre open-label trial, 424 infants who received DTaP-IPV//PRP approximately T at 6, 10 and 14 weeks of age were also randomized to receive hepatitis B vaccine at either 6, 10 and 14 weeks or 0, 6 and 14 weeks of age. Antibody levels were determined at 6 and 18 weeks of age, and reactogenicity was monitored using parental reports. Immunogenicity was high for all vaccine antigens and was similar to that in a historical control study. After primary vaccination, 98.7% of all infants had an anti-PRP antibody titre &gt; 0.15 microg/ml. Seroprotection against poliovirus type-1, -2 and -3 and tetanus was obtained in all infants, and against diphthe...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and safety of a DTaP-IPV//PRP approximately T combination vaccine given with hepatitis B vaccine: a randomized open-label trial","attachmentId":39290159,"attachmentType":"pdf","work_url":"https://www.academia.edu/16980685/Immunogenicity_and_safety_of_a_DTaP_IPV_PRP_approximately_T_combination_vaccine_given_with_hepatitis_B_vaccine_a_randomized_open_label_trial","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/16980685/Immunogenicity_and_safety_of_a_DTaP_IPV_PRP_approximately_T_combination_vaccine_given_with_hepatitis_B_vaccine_a_randomized_open_label_trial"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="83687820" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/83687820/Immunogenicity_of_two_diphtheria_tetanus_whole_cell_pertussis_hepatitis_B_vaccines_in_infants_A_comparative_trial">Immunogenicity of two diphtheria-tetanus-whole cell pertussis-hepatitis B vaccines in infants: A comparative trial</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="106494209" href="https://independent.academia.edu/drprajaktbarde">dr prajakt barde</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity of two diphtheria-tetanus-whole cell pertussis-hepatitis B vaccines in infants: A comparative trial","attachmentId":88950764,"attachmentType":"pdf","work_url":"https://www.academia.edu/83687820/Immunogenicity_of_two_diphtheria_tetanus_whole_cell_pertussis_hepatitis_B_vaccines_in_infants_A_comparative_trial","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/83687820/Immunogenicity_of_two_diphtheria_tetanus_whole_cell_pertussis_hepatitis_B_vaccines_in_infants_A_comparative_trial"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="49725247" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/49725247/A_phase_III_randomized_controlled_study_to_assess_the_immunogenicity_and_tolerability_of_DTPw_HBV_Hib_a_liquid_pentavalent_vaccine_in_Indian_infants">A phase III randomized, controlled study to assess the immunogenicity and tolerability of DTPw-HBV-Hib, a liquid pentavalent vaccine in Indian infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="154784666" href="https://independent.academia.edu/ProfVishwanathPatil">Prof. Vishwanath Patil</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A phase III randomized, controlled study to assess the immunogenicity and tolerability of DTPw-HBV-Hib, a liquid pentavalent vaccine in Indian infants","attachmentId":67987438,"attachmentType":"pdf","work_url":"https://www.academia.edu/49725247/A_phase_III_randomized_controlled_study_to_assess_the_immunogenicity_and_tolerability_of_DTPw_HBV_Hib_a_liquid_pentavalent_vaccine_in_Indian_infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/49725247/A_phase_III_randomized_controlled_study_to_assess_the_immunogenicity_and_tolerability_of_DTPw_HBV_Hib_a_liquid_pentavalent_vaccine_in_Indian_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="2495889" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life">Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2293675" href="https://ankara.academia.edu/BetulUlukol">Betul Ulukol</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1999</p><p class="ds-related-work--abstract ds2-5-body-sm">This study was designed to assess the immunogenicity of a vaccine combining diphtheria and tetanus toxoids, acellular pertussis vaccine, and inactivated poliovirus vaccine reconstituting Haemophilus influenzae type b polysaccharide conjugated to tetanus protein (DTaP-IPV//PRP-T; Pasteur Mérieux Connaught, Lyon, France) administered simultaneously in association with hepatitis B vaccine (RECOMBIVAX ™ Merck, Sharp & Dohme, West Point, PA, USA) for the primary immunization of infants. The vaccines were administered at two, three and four months of age. One hundred and sixty-two healthy infants, aged 8–10 weeks, were enrolled in the study. Blood samples were taken before the first dose and 4 weeks after the third dose. The infants were observed for 15 minutes after vaccination for any immediate reaction. Adverse events requiring a medical consultation were recorded by the parents in a diary over the 7 days following vaccination. Four weeks after the third immunization, the percentages of infants fulfilling seroconversion criteria were 98.9% for pertussis toxin, 95.9% for filamentous haemagglutinin, 100.0% for tetanus, 100.0% for diphtheria, 99.3% for poliovirus type 1, 100.0% for both poliovirus types 2 and 3, 98.0% for Haemophilus influenzae type b, and 100% for hepatitis B surface antigen. No vaccine-related serious adverse event was reported. The simultaneous administration of DTaP-IPV//PRP-T and hepatitis B vaccines at two, three and four months of age yielded clinically satisfactory immune responses to all antigens compared with historical controls and gave a good safety profile.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life","attachmentId":50600022,"attachmentType":"pdf","work_url":"https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":42850597,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":42850597,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_42850597" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/4278383/Primary_vaccination_of_infants_with_diphtheria_tetanus_acellular_pertussis_hepatitis_B_virus_inactivated_polio_virus_and_Haemophilus_influenzae_type_b_vaccines_given_as_either_separate_or_mixed_injections"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="123908120" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/123908120/A_fully_liquid_diphtheria_tetanus_five_component_acellular_pertussis_inactivated_poliomyelitis_Haemophilus_influenzae_type_b_conjugate_vaccine_immunogenicity_and_safety_of_primary_vaccination_in_Taiwanese_infants">A fully liquid diphtheria–tetanus–five component acellular pertussis–inactivated poliomyelitis–Haemophilus influenzae type b conjugate vaccine: immunogenicity and safety of primary vaccination in Taiwanese infants</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="317575668" href="https://independent.academia.edu/EstebanORTIZ204">Esteban ORTIZ</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Infectious Diseases, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A fully liquid diphtheria–tetanus–five component acellular pertussis–inactivated poliomyelitis–Haemophilus influenzae type b conjugate vaccine: immunogenicity and safety of primary vaccination in Taiwanese 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="15536449" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age">Reactogenicity of DTPa-HBV/Hib vaccine administered as a single injection vs DTPa-HBV and Hib vaccines administered simultaneously at separate sites, to infants at 2, 4 and 6 months of age</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34691855" href="https://independent.academia.edu/Jos%C3%A9Garciasicilia">José Garcia-sicilia</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reactogenicity of DTPa-HBV/Hib vaccine administered as a single injection vs DTPa-HBV and Hib vaccines administered simultaneously at separate sites, to infants at 2, 4 and 6 months of age","attachmentId":43111726,"attachmentType":"pdf","work_url":"https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/15536449/Reactogenicity_of_DTPa_HBV_Hib_vaccine_administered_as_a_single_injection_vs_DTPa_HBV_and_Hib_vaccines_administered_simultaneously_at_separate_sites_to_infants_at_2_4_and_6_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="92826712" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine">Reactogenicity and Immunogenicity Profiles of a Novel Pentavalent Diphtheria-Tetanus???Whole Cell Pertussis???Hepatitis B and Haemophilus Influenzae Type B Vaccine</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="249836346" href="https://independent.academia.edu/TheinAungMyat">Aung Myat Thein</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Pediatric Infectious Disease Journal, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reactogenicity and Immunogenicity Profiles of a Novel Pentavalent Diphtheria-Tetanus???Whole Cell Pertussis???Hepatitis B and Haemophilus Influenzae Type B Vaccine","attachmentId":95732621,"attachmentType":"pdf","work_url":"https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="14975690" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14975690/Evaluation_of_a_combined_tetravalent_diphtheria_tetanus_whole_cell_pertussis_and_hepatitis_B_candidate_vaccine_administered_to_healthy_infants_according_to_a_three_dose_vaccination_schedule">Evaluation of a combined tetravalent diphtheria, tetanus, whole-cell pertussis and hepatitis B candidate vaccine administered to healthy infants according to a three-dose vaccination schedule</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33970761" href="https://independent.academia.edu/PVandepapeliere">P. Vandepapeliere</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evaluation of a combined tetravalent diphtheria, tetanus, whole-cell pertussis and hepatitis B candidate vaccine administered to healthy infants according to a three-dose vaccination schedule","attachmentId":43682292,"attachmentType":"pdf","work_url":"https://www.academia.edu/14975690/Evaluation_of_a_combined_tetravalent_diphtheria_tetanus_whole_cell_pertussis_and_hepatitis_B_candidate_vaccine_administered_to_healthy_infants_according_to_a_three_dose_vaccination_schedule","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link 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According to the EPI (Expanded Programme for Immunization) Schedule and Following Hepatitis B Vaccination at Birth</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="6266956" href="https://independent.academia.edu/mariettareyes">marietta reyes</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A New DTPw-HBV/Hib Vaccine is Immunogenic and Safe when Administered According to the EPI (Expanded Programme for Immunization) Schedule and Following Hepatitis B Vaccination at 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js-related-work-sidebar-card" data-collection-position="7" data-entity-id="5197071" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/5197071/A_liquid_hexavalent_combined_vaccine_against_diphtheria_tetanus_pertussis_poliomyelitis_Haemophilus_influenzae_type_B_and_hepatitis_B_review_of_immunogenicity_and_safety">A liquid hexavalent combined vaccine against diphtheria, tetanus, pertussis, poliomyelitis, Haemophilus influenzae type B and hepatitis B: review of immunogenicity and safety</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="6966196" href="https://independent.academia.edu/AlmaMunoz">Alma Munoz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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href="https://www.academia.edu/5197071/A_liquid_hexavalent_combined_vaccine_against_diphtheria_tetanus_pertussis_poliomyelitis_Haemophilus_influenzae_type_B_and_hepatitis_B_review_of_immunogenicity_and_safety"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="14000140" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14000140/Facilitating_the_WHO_expanded_program_of_immunization_the_clinical_profile_of_a_combined_diphtheria_tetanus_pertussis_hepatitis_B_and_Haemophilus_influenzae_type_b_vaccine">Facilitating the WHO expanded program of immunization: the clinical profile of a combined diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae type b vaccine</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33036876" href="https://independent.academia.edu/VytautasUsonis">Vytautas Usonis</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Infectious Diseases, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Facilitating the WHO expanded program of immunization: the clinical profile of a combined diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae type b vaccine","attachmentId":44716365,"attachmentType":"pdf","work_url":"https://www.academia.edu/14000140/Facilitating_the_WHO_expanded_program_of_immunization_the_clinical_profile_of_a_combined_diphtheria_tetanus_pertussis_hepatitis_B_and_Haemophilus_influenzae_type_b_vaccine","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/14000140/Facilitating_the_WHO_expanded_program_of_immunization_the_clinical_profile_of_a_combined_diphtheria_tetanus_pertussis_hepatitis_B_and_Haemophilus_influenzae_type_b_vaccine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="62049503" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62049503/Safety_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_vaccine_administered_according_to_two_different_primary_vaccination_schedules">Safety and immunogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine administered according to two different primary vaccination schedules</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31850906" href="https://unito.academia.edu/CarlaZotti">Carla Zotti</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and immunogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine administered according to two different primary vaccination schedules","attachmentId":74917132,"attachmentType":"pdf","work_url":"https://www.academia.edu/62049503/Safety_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_vaccine_administered_according_to_two_different_primary_vaccination_schedules","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/62049503/Safety_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_vaccine_administered_according_to_two_different_primary_vaccination_schedules"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="4278382" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4278382/Immunogenicity_and_safety_of_DTaP_IPV_PRP_T_combination_vaccine_given_with_hepatitis_B_vaccine_a_randomized_open_label_trial">Immunogenicity and safety of DTaP-IPV/PRP-T combination vaccine given with hepatitis B vaccine: a randomized open-label trial</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5193659" href="https://independent.academia.edu/OrtizEsteban">Esteban Ortiz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Bulletin of The World Health Organization, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and safety of DTaP-IPV/PRP-T combination vaccine given with hepatitis B vaccine: a randomized open-label trial","attachmentId":31748861,"attachmentType":"pdf","work_url":"https://www.academia.edu/4278382/Immunogenicity_and_safety_of_DTaP_IPV_PRP_T_combination_vaccine_given_with_hepatitis_B_vaccine_a_randomized_open_label_trial","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link 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