Validate Your KRAS-Targeting Strategy

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Whitepaper","url":"https:\/\/news.certisoncology.com\/ras-mutations-in-cancer-emerging-drug-development-strategies","target":""},"media-option":"image","image":{"image":{"ID":5625,"id":5625,"title":"tumor-microenvironment-optimized","filename":"tumor-microenvironment-optimized.webp","filesize":83012,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized.webp","link":"https:\/\/www.certisoncology.com\/kras-targeted-oncology-drug-development\/tumor-microenvironment-optimized\/","alt":"tumor-microenvironment","author":"6","description":"tumor-microenvironment","caption":"tumor-microenvironment","name":"tumor-microenvironment-optimized","status":"inherit","uploaded_to":5537,"date":"2023-09-25 19:27:44","modified":"2023-09-25 19:28:00","menu_order":0,"mime_type":"image\/webp","type":"image","subtype":"webp","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":2000,"height":1500,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized-150x150.webp","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized-720x540.webp","medium-width":300,"medium-height":225,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized-768x576.webp","medium_large-width":768,"medium_large-height":576,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized-960x720.webp","large-width":960,"large-height":720,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized-1536x1152.webp","1536x1536-width":1536,"1536x1536-height":1152,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized.webp","2048x2048-width":2000,"2048x2048-height":1500,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized-540x405.webp","small-width":540,"small-height":405,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized-540x540.webp","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized-720x720.webp","square-md-width":720,"square-md-height":720,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized-640x920.webp","portrait-width":640,"portrait-height":920,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/tumor-microenvironment-optimized-960x640.webp","landscape-width":960,"landscape-height":640}},"href":"","title":" ","description":"<p>Understanding how KRAS inhibitors affect the tumor microenvironment (TME) and anti-tumor immunity is crucial for developing rational therapeutic combination strategies that fight KRAS mutations in cancer.<sup>1<\/sup> Traditional models, such as syngeneic tumor models (often used in oncology drug development) are homogeneous and therefore do not represent the complex tumor microenvironment.<sup>2<\/sup> Talk to us about the use of clinically relevant, humanized orthotopic PDX models that recapitulate the TME.<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"left to right","vertical-align":"top"}}"></component-5f6e3c3648fee><component-5f6e4355bed24 :arr="{"content":"<p>Certis Oncology is currently engaged in an observational clinical research study to evaluate KRAS mutations in colorectal cancers, and to assess concordance across CertisAI\u2122 predictions, orthotopic PDX cancer models and cancer patients. Ask us about adding your KRAS-targeted compound to the list of drugs being tested <em>in vivo<\/em>, or about your own co-clinical trial initiatives.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.certisoncology.com\/observational-clinical-research-study-testing-kras-targeting-therapies\/\">Learn More<\/a><\/p>\n","callout":{"headline":"Clinical Research Study & Co-Clinical Trial Enrollment: Maintaining a Strong Connection to the Clinic","content":"","image":{"ID":5585,"id":5585,"title":"clia-logo-2","filename":"clia-logo-2-e1695333769119.png","filesize":12928,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-e1695333769119.png","link":"https:\/\/www.certisoncology.com\/kras-targeted-oncology-drug-development\/clia-logo-2\/","alt":"","author":"6","description":"","caption":"","name":"clia-logo-2","status":"inherit","uploaded_to":5537,"date":"2023-09-21 22:00:12","modified":"2023-09-21 22:00:12","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":150,"height":68,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-e1695333769119.png","medium-width":150,"medium-height":68,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-e1695333769119.png","medium_large-width":150,"medium_large-height":68,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-e1695333769119.png","large-width":150,"large-height":68,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-e1695333769119.png","1536x1536-width":150,"1536x1536-height":68,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-e1695333769119.png","2048x2048-width":150,"2048x2048-height":68,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-e1695333769119.png","small-width":150,"small-height":68,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-e1695333769119.png","square-sm-width":150,"square-sm-height":68,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-e1695333769119.png","square-md-width":150,"square-md-height":68,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-e1695333769119.png","portrait-width":150,"portrait-height":68,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/clia-logo-2-e1695333769119.png","landscape-width":150,"landscape-height":68}}},"layout":{"background":"white","style":"card","columns":"12","callout-columns":"2"}}"></component-5f6e4355bed24><component-5f6e424bba9c9 :arr="{"headline":"Ready to Move Your KRAS-Targeting Therapeutic Program Forward?","description":"<p><a href=\"https:\/\/meetings.hubspot.com\/dstanton1\" target=\"_blank\" rel=\"noopener\">Book a meeting<\/a> if preferred or contact us at <a href=\"mailto:busdev@certisoncology.com\" target=\"_blank\" rel=\"noopener\">busdev@certisoncology.com<\/a> or 858-988-1033 to discuss your next preclinical study.<\/p>\n","cta":"","layout":{"background":"cells","style":"default","sticky":false}}"></component-5f6e424bba9c9><component-5f7e3c2a849f9 :arr="{"title":"RAS-Mutant Cancer Models","description":"<h2 id=\"Download-Data-Pack\">Download Data Pack <a href=\"#Download-Data-Pack\"><\/a><\/h2>\n","id":"0de68203-7587-4a3a-9e17-054281e27fa6","options":{"active":""}}"></component-5f7e3c2a849f9><component-5f6e4355bed24 :arr="{"content":"<p><a href=\"https:\/\/www.certisoncology.com\/for-drug-developers\/\" target=\"_blank\" rel=\"noopener\">Certis Oncology Solutions<\/a> is the only translational partner that combines predictive AI with advanced preclinical cancer models to evaluate efficacy and understand the complex mechanisms of action inherent to antineoplastics that target RAS pathways.<\/p>\n","callout":{"headline":"Only Certis Delivers KRAS-Targeted Oncology Intelligence\u00ae","content":"","image":false},"layout":{"background":"gray","style":"card","columns":"12","callout-columns":"2"}}"></component-5f6e4355bed24><component-5f6e4355bed24 :arr="{"content":"<h2>References<\/h2>\n<p><strong>1<\/strong> Boumelha J et al. <a href=\"https:\/\/www.cancer.gov\/research\/key-initiatives\/ras\/news-events\/dialogue-blog\/2022\/g12ci-antipd1-combo\" target=\"_blank\" rel=\"noopener\">KRASG12C Inhibition Drives Anti-Tumour Immunity in Lung Cancer But Combinations With Anti-PD1 Immunotherapy May Only Benefit Patients With \u2018Inflamed\u2019 Tumours<\/a>. NCI (Online). Nov. 14, 2022.<br \/>\n<strong>2<\/strong> Bareham B et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8423639\/\" target=\"_blank\" rel=\"noopener\">Modeling Human Tumor-Immune Environments In Vivo for the Preclinical Assessment of Immunotherapies<\/a>. <em>Cancer Immunol Immunother<\/em>. Oct 2021;70(10):2737-2750.<\/p>\n","callout":{"headline":"","content":"","image":false},"layout":{"background":"gray","style":"default","columns":"12","callout-columns":"2"}}"></component-5f6e4355bed24> </div> <footer> <div class="container"> <div class="d-flex flex-wrap flex-md-nowrap"> <div class="mb-4 mb-md-2 mb-lg-0 mr-sm-4"> <figure class="mb-3 mr-lg-6"> <img class="img-fluid d-block" src="/wp-content/themes/certis/images/certis-logo-lockup-white.svg"> </figure> <address> <div> <span class="street-address d-block">5626 Oberlin Drive, Suite 110</span> <span class="city state zip d-block mb-3">San Diego, CA 92121</span> </div> <div> <span class="phone d-block">Drug Development: 858-988-1033</span> <span class="phone d-block">Patients & Oncologists: 858-228-4110</span> <span class="phone d-block">Main: 858-952-1820</span> </div> </address> </div> <nav class="flex-grow-1"> <ul class="sections ml-0 ml-md-4"> <li> <h4 style="text-transform: uppercase;">Drug Developers</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/for-drug-developers/predictive-oncology-intelligence/">CertisAI™</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/cancer-models-preclinical-studies/">Cancer Models</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/custom-model-development/">Custom Model Development</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/in-vitro-ex-vivo-pharmacology/">In Vitro/Ex Vivo Pharmacology</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/in-vivo-pharmacology/">In Vivo Pharmacology</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/imaging-endpoint-analysis/">Imaging/Endpoint Analysis</a></li> <li><a href="https://www.certisoncology.com/for-drug-developers/immuno-oncology/">Immuno-Oncology</a></li> </ul> </li> <li> <h4 style="text-transform: uppercase;">Oncologists</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/for-oncologists/order-yourpdx/">Order YourPDX<sup>®</sup></a></li> <li><a href="https://www.certisoncology.com/for-oncologists/clinical-research/">Clinical Research</a></li> <li><a href="https://www.certisoncology.com/for-oncologists/patient-education/">Patient Education</a></li> </ul> </li> <li> <h4 style="text-transform: uppercase;">Resource Library</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/resources/cancer-market-facts/">Cancer Facts</a></li> <li><a href="https://www.certisoncology.com/resources/clinical-results/">Clinical Results</a></li> <li><a href="https://www.certisoncology.com/resources/supporting-research/">Supporting Research</a></li> <li><a href="https://www.certisoncology.com/resources/media/">Media</a></li> <li><a href="https://whitepapers.certisoncology.com/">White Papers</a></li> </ul> </li> <li> <h4 style="text-transform: uppercase;">About</h4> <ul class="child-pages"> <li><a href="https://www.certisoncology.com/about-us/mission-vision-values/">Mission, Vision & Values</a></li> <li><a href="https://www.certisoncology.com/about-us/our-team/">Team</a></li> <li><a href="https://www.certisoncology.com/about-us/our-story/">Our Story</a></li> <li><a href="https://www.certisoncology.com/about-us/careers/">Careers</a></li> <li><a href="https://www.certisoncology.com/about-us/news/">Company News</a></li> <li><a href="https://www.certisoncology.com/contact-us/">Contact Us</a></li> <li><a href="https://oncointel.certisoncology.com/">Login</a></li> <li><a href="https://www.certisoncology.com/privacy-policy/">Privacy Policy</a></li> </ul> </li> </ul> </nav> </div> <div class="d-flex justify-content-between align-items-end mt-2"> <div class="social-media icons"> <ul> <li><a href="https://www.facebook.com/CertisOncology" target="_blank" class="facebook"></a></li> <li><a href="https://www.linkedin.com/company/certis-oncology" target="_blank" class="linkedin"></a></li> <li><a href="https://twitter.com/CertisOncology" target="_blank" class="twitter"></a></li> <li><a href="https://www.instagram.com/certis_oncology" target="_blank" class="instagram"></a></li> <li><a href="https://www.youtube.com/channel/UCeX4_jh3RlNKxQxZ89_utjg" target="_blank" class="youtube"></a></li> <li><a href="https://blog.certisoncology.com/" target="_blank" class="blog"></a></li> </ul> </div> <div class="d-flex justify-content-end"> <figure class="mouse mx-auto"> <img class="img-fluid d-block" src="/wp-content/themes/certis/images/certis-footer-mouse.svg"> </figure> </div> </div> <hr /> <div class="row"> <div class="col"> <div class="copyright mb-2 mb-sm-0"> <span class="d-block">©2024 Certis Oncology Solutions. 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Validate Your KRAS-Targeting Strategy - Certis Oncology