CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>University of Veterinary Medicine Vienna | Functional Cancer Genomics - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "departments", 'action': "show_works", 'controller_action': 'departments#show_works', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="cTbCRJpIEE5YyQlRcyE+9VETYqx/q7hlhW45Nx6FDakciuvrHjV5jBAYIyuSHUS2PdHoJU4sHu0hO6pMWm94Cw==" /> <link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="description" content="Academia.edu is the platform to share, find, and explore 50 Million research papers. Join us to accelerate your research needs & academic interests." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'departments'; var $action_name = "show_works"; var $rails_env = 'production'; var $app_rev = '12e896337d6d87b1b7832f17b5dc6a26376c2655'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15252,"monthly_visitors":"119 million","monthly_visitor_count":119262695,"monthly_visitor_count_in_millions":119,"user_count":278616090,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1733988384000); window.Aedu.timeDifference = new Date().getTime() - 1733988384000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-0fb6fc03c471832908791ad7ddba619b6165b3ccf7ae0f65cf933f34b0b660a7.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-2eebbf16f94e23df09908fc0eb355e7d088296bc7bbbbe96567743814345fdd9.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-086d9084944b0c8a793ea96ac398b4180db6177bb674e9655034fb25e834c8b4.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://vetmeduni.academia.edu/Departments/Functional_Cancer_Genomics/Documents" /> </head>   <body class='c-departments a-show_works logged_out u-bgColorWhite'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav no-xs no-sm no-md"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <div class="DesignSystem" style="margin-top:-40px"><div class="PageHeader"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><div class="u-floatLeft u-fs24 u-tcGrayDarkest"><span class="PageHeader-title u-m0x u-fw700 u-mr5x u-pr5x u-borderColorGrayLight u-borderRight1"><a href="https://vetmeduni.academia.edu/"><span class="u-linkUnstyled u-tcGrayDarkest">University of Veterinary Medicine Vienna</span></a></span><h1 class="u-m0x u-fw300 u-fs24 u-displayInline">Functional Cancer Genomics</h1></div><div class="u-floatRight u-mt1x"></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline"><li class="u-floatLeft u-pr5x u-mr5x u-borderColorGrayLight u-borderRight1"><a href="https://vetmeduni.academia.edu/"><span><i class="fa fa-arrow-left"></i>  All Departments</span></a></li><li class="u-floatLeft active"><a href="https://vetmeduni.academia.edu/Departments/Functional_Cancer_Genomics/Documents">5 Papers</a></li><li class="u-floatLeft"><a href="https://vetmeduni.academia.edu/Departments/Functional_Cancer_Genomics">1 Researchers</a></li></ul></div></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="u-ph0x"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16315106 coauthored" data-work_id="16315106" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16315106/Direct_glucocorticoid_receptor_Stat5_interaction_in_hepatocytes_controls_body_size_and_maturation_related_gene_expression">Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The glucocorticoid receptor regulates transcription through DNA binding as well as through cross-talk with other transcription factors. In hepatocytes, the glucocorticoid receptor is critical for normal postnatal growth. Using... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16315106" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The glucocorticoid receptor regulates transcription through DNA binding as well as through cross-talk with other transcription factors. In hepatocytes, the glucocorticoid receptor is critical for normal postnatal growth. Using hepatocyte-specific and domain-selective mutations in the mouse we show that Stat5 in hepatocytes is essential for normal postnatal growth and that it mediates the growth-promoting effect of the glucocorticoid receptor through a direct interaction involving the Nterminal tetramerization domain of Stat5b. This interaction mediates a selective and unexpectedly extensive part of the transcriptional actions of these molecules since it controls the expression of gene sets involved in growth and sexual maturation.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16315106" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ffdade58bf8311282b5a3bf3381ced46" rel="nofollow" data-download="{"attachment_id":42529679,"asset_id":16315106,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42529679/download_file?st=MTczMzk4ODM4Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35485628" href="https://vetmeduni.academia.edu/RMoriggl">R. Moriggl</a><script data-card-contents-for-user="35485628" type="text/json">{"id":35485628,"first_name":"R.","last_name":"Moriggl","domain_name":"vetmeduni","page_name":"RMoriggl","display_name":"R. Moriggl","profile_url":"https://vetmeduni.academia.edu/RMoriggl","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16315106">+1</span><div class="hidden js-additional-users-16315106"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/AndreasReimann">Andreas Reimann</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16315106'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16315106').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_16315106 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16315106"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16315106, container: ".js-paper-rank-work_16315106", }); });</script></li><li class="js-percentile-work_16315106 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16315106; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16315106"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16315106 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16315106"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16315106; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16315106]").text(description); $(".js-view-count-work_16315106").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16315106").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16315106"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="27784" href="https://www.academia.edu/Documents/in/Gene_expression">Gene expression</a>, <script data-card-contents-for-ri="27784" type="text/json">{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="37834" href="https://www.academia.edu/Documents/in/Western_blotting">Western blotting</a>, <script data-card-contents-for-ri="37834" type="text/json">{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="74780" href="https://www.academia.edu/Documents/in/Mutation">Mutation</a><script data-card-contents-for-ri="74780" type="text/json">{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16315106]'), work: {"id":16315106,"title":"Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression","created_at":"2015-09-30T01:57:01.865-07:00","owner_id":35423477,"url":"https://www.academia.edu/16315106/Direct_glucocorticoid_receptor_Stat5_interaction_in_hepatocytes_controls_body_size_and_maturation_related_gene_expression","slug":"Direct_glucocorticoid_receptor_Stat5_interaction_in_hepatocytes_controls_body_size_and_maturation_related_gene_expression","dom_id":"work_16315106","summary":"The glucocorticoid receptor regulates transcription through DNA binding as well as through cross-talk with other transcription factors. In hepatocytes, the glucocorticoid receptor is critical for normal postnatal growth. Using hepatocyte-specific and domain-selective mutations in the mouse we show that Stat5 in hepatocytes is essential for normal postnatal growth and that it mediates the growth-promoting effect of the glucocorticoid receptor through a direct interaction involving the Nterminal tetramerization domain of Stat5b. This interaction mediates a selective and unexpectedly extensive part of the transcriptional actions of these molecules since it controls the expression of gene sets involved in growth and sexual maturation.","publication":"Genes \u0026 Development","publication_with_fallback":"Genes \u0026 Development","downloadable_attachments":[{"id":42529679,"asset_id":16315106,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42529679/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42529679/Direct_glucocorticoid_receptor-Stat5_int20160210-26457-1l1napo-libre.pdf?1455091565=\u0026response-content-disposition=attachment%3B+filename%3DDirect_glucocorticoid_receptor_Stat5_int.pdf\u0026Expires=1733991983\u0026Signature=Wa5vmIzBi8Rao1~tWFOQRt94hG28cDyrOb41NMHv3JO5NA1PpAxbsE7cbQPngC76E8BiaH3jeDk4izyISex-gpq7wQFpBUKolxpunLhP3jmMRMwtWl4Cb7jOkWtk3o1TvMP3Tz-YIg2Hu3p3DZMxhjP~tZ8RGumt0O8tKKlv337DjRjC~sOqvg9Ed3LODTjcTdqjnLTKC4NrUI64EFlha2cIV7pEiqlURyvvNx~igcBuME225kyGmMU3fkZwNkn91tXN4agIieQ7QBjvGc5ufwqjvcmUvPEAGF~~coWXg7VqW-OAdOxUeZ100hHBmNgFhBz1mK7V27llIbXQ4K04BQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42529679/download_file?st=MTczMzk4ODM4Myw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42529679/mini_magick20190217-18982-m3e13w.png?1550439484"}],"downloadable_attachments_with_full_thumbnails":[{"id":42529679,"asset_id":16315106,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42529679/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42529679/Direct_glucocorticoid_receptor-Stat5_int20160210-26457-1l1napo-libre.pdf?1455091565=\u0026response-content-disposition=attachment%3B+filename%3DDirect_glucocorticoid_receptor_Stat5_int.pdf\u0026Expires=1733991983\u0026Signature=Wa5vmIzBi8Rao1~tWFOQRt94hG28cDyrOb41NMHv3JO5NA1PpAxbsE7cbQPngC76E8BiaH3jeDk4izyISex-gpq7wQFpBUKolxpunLhP3jmMRMwtWl4Cb7jOkWtk3o1TvMP3Tz-YIg2Hu3p3DZMxhjP~tZ8RGumt0O8tKKlv337DjRjC~sOqvg9Ed3LODTjcTdqjnLTKC4NrUI64EFlha2cIV7pEiqlURyvvNx~igcBuME225kyGmMU3fkZwNkn91tXN4agIieQ7QBjvGc5ufwqjvcmUvPEAGF~~coWXg7VqW-OAdOxUeZ100hHBmNgFhBz1mK7V27llIbXQ4K04BQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42529679/download_file?st=MTczMzk4ODM4Myw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42529679/mini_magick20190217-18982-m3e13w.png?1550439484"}],"has_pdf":true,"has_fulltext":true,"page_count":6,"ordered_authors":[{"id":35485628,"first_name":"R.","last_name":"Moriggl","domain_name":"vetmeduni","page_name":"RMoriggl","display_name":"R. Moriggl","profile_url":"https://vetmeduni.academia.edu/RMoriggl","photo":"/images/s65_no_pic.png"},{"id":35423477,"first_name":"Andreas","last_name":"Reimann","domain_name":"independent","page_name":"AndreasReimann","display_name":"Andreas Reimann","profile_url":"https://independent.academia.edu/AndreasReimann","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression","nofollow":false},{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation","nofollow":false},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":164264,"name":"Body Size","url":"https://www.academia.edu/Documents/in/Body_Size"},{"id":432593,"name":"Hepatocytes","url":"https://www.academia.edu/Documents/in/Hepatocytes"},{"id":440820,"name":"Chromatin Immunoprecipitation","url":"https://www.academia.edu/Documents/in/Chromatin_Immunoprecipitation"},{"id":974764,"name":"Sexual Maturation","url":"https://www.academia.edu/Documents/in/Sexual_Maturation"},{"id":1810445,"name":"Gene expression profiling","url":"https://www.academia.edu/Documents/in/Gene_expression_profiling"}],"publication_year":2007,"publication_year_with_fallback":2007,"paper_rank":null,"all_time_views":17,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16361359" data-work_id="16361359" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16361359/A_small_amphipathic_%CE%B1_helical_region_is_required_for_transcriptional_activities_and_proteasome_dependent_turnover_of_the_tyrosine_phosphorylated_Stat5">A small amphipathic α-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cytokines induce the tyrosine phosphorylation and associated activation of signal transducers and activators of transcription (Stat). The mechanisms by which this response is terminated are largely unknown. Among a variety of inhibitors... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16361359" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cytokines induce the tyrosine phosphorylation and associated activation of signal transducers and activators of transcription (Stat). The mechanisms by which this response is terminated are largely unknown. Among a variety of inhibitors examined, the proteasome inhibitors ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16361359" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="82f1e71b5183cccc3337c04accd5124b" rel="nofollow" data-download="{"attachment_id":42511682,"asset_id":16361359,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42511682/download_file?st=MTczMzk4ODM4Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35485628" href="https://vetmeduni.academia.edu/RMoriggl">R. Moriggl</a><script data-card-contents-for-user="35485628" type="text/json">{"id":35485628,"first_name":"R.","last_name":"Moriggl","domain_name":"vetmeduni","page_name":"RMoriggl","display_name":"R. Moriggl","profile_url":"https://vetmeduni.academia.edu/RMoriggl","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16361359 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16361359"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16361359, container: ".js-paper-rank-work_16361359", }); });</script></li><li class="js-percentile-work_16361359 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16361359; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16361359"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16361359 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16361359"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16361359; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16361359]").text(description); $(".js-view-count-work_16361359").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16361359").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16361359"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="42132" href="https://www.academia.edu/Documents/in/Transcription">Transcription</a>, <script data-card-contents-for-ri="42132" type="text/json">{"id":42132,"name":"Transcription","url":"https://www.academia.edu/Documents/in/Transcription","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="81271" href="https://www.academia.edu/Documents/in/Proteasome">Proteasome</a><script data-card-contents-for-ri="81271" type="text/json">{"id":81271,"name":"Proteasome","url":"https://www.academia.edu/Documents/in/Proteasome","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16361359]'), work: {"id":16361359,"title":"A small amphipathic α-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5","created_at":"2015-10-01T06:43:56.700-07:00","owner_id":35485628,"url":"https://www.academia.edu/16361359/A_small_amphipathic_%CE%B1_helical_region_is_required_for_transcriptional_activities_and_proteasome_dependent_turnover_of_the_tyrosine_phosphorylated_Stat5","slug":"A_small_amphipathic_α_helical_region_is_required_for_transcriptional_activities_and_proteasome_dependent_turnover_of_the_tyrosine_phosphorylated_Stat5","dom_id":"work_16361359","summary":"Cytokines induce the tyrosine phosphorylation and associated activation of signal transducers and activators of transcription (Stat). The mechanisms by which this response is terminated are largely unknown. Among a variety of inhibitors examined, the proteasome inhibitors ...","publication":"The EMBO …","publication_with_fallback":"The EMBO …","downloadable_attachments":[{"id":42511682,"asset_id":16361359,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42511682/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42511682/A_small_amphipathic_alpha-helical_region20160209-28311-hua91k-libre.pdf?1455058272=\u0026response-content-disposition=attachment%3B+filename%3DA_small_amphipathic__helical_region_is.pdf\u0026Expires=1733991983\u0026Signature=QYAa3jrmXmmGhLeGWGS4z0WRG2jxzOM7yYgOFCbWpQsu4y9CARUsV7XftFADzc1W8AY7flpAK1-78Ymx6lJrScz3RUoCHpCX1uS0nQ0Iv8r0Dvm24VEI7GrcRjCepltOPrBcJhDAMorKpTOFCX5eK~cRMCLLxQZ8uMgUWOkVmRqValSwrAoWvFqj46i8dq15kdDogGOpgF552I9s2ZjzKQx9qSC0u1FNbDhCymwP-~B5bZ~GUQXsIJV6xuMJDCWgl6XoFL4oXzkBW60oE3B0SERSmtVuPIEWKxAGoUw8FRYWjfmC8KNREbsyw9SNAONViAa2AeFIKuaZ-kTQt5x0Kg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42511682/download_file?st=MTczMzk4ODM4Myw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42511682/mini_magick20190217-31041-frsz1e.png?1550441919"}],"downloadable_attachments_with_full_thumbnails":[{"id":42511682,"asset_id":16361359,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42511682/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42511682/A_small_amphipathic_alpha-helical_region20160209-28311-hua91k-libre.pdf?1455058272=\u0026response-content-disposition=attachment%3B+filename%3DA_small_amphipathic__helical_region_is.pdf\u0026Expires=1733991983\u0026Signature=QYAa3jrmXmmGhLeGWGS4z0WRG2jxzOM7yYgOFCbWpQsu4y9CARUsV7XftFADzc1W8AY7flpAK1-78Ymx6lJrScz3RUoCHpCX1uS0nQ0Iv8r0Dvm24VEI7GrcRjCepltOPrBcJhDAMorKpTOFCX5eK~cRMCLLxQZ8uMgUWOkVmRqValSwrAoWvFqj46i8dq15kdDogGOpgF552I9s2ZjzKQx9qSC0u1FNbDhCymwP-~B5bZ~GUQXsIJV6xuMJDCWgl6XoFL4oXzkBW60oE3B0SERSmtVuPIEWKxAGoUw8FRYWjfmC8KNREbsyw9SNAONViAa2AeFIKuaZ-kTQt5x0Kg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42511682/download_file?st=MTczMzk4ODM4Myw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42511682/mini_magick20190217-31041-frsz1e.png?1550441919"}],"has_pdf":true,"has_fulltext":true,"page_count":8,"ordered_authors":[{"id":35485628,"first_name":"R.","last_name":"Moriggl","domain_name":"vetmeduni","page_name":"RMoriggl","display_name":"R. Moriggl","profile_url":"https://vetmeduni.academia.edu/RMoriggl","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":42132,"name":"Transcription","url":"https://www.academia.edu/Documents/in/Transcription","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false},{"id":81271,"name":"Proteasome","url":"https://www.academia.edu/Documents/in/Proteasome","nofollow":false}],"publication_year":2000,"publication_year_with_fallback":2000,"paper_rank":null,"all_time_views":11,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16361360" data-work_id="16361360" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16361360/The_role_of_Stat5_transcription_factors_as_tumor_suppressors_or_oncogenes">The role of Stat5 transcription factors as tumor suppressors or oncogenes</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16361360" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2b96ced94a8811859630264707a20702" rel="nofollow" data-download="{"attachment_id":42511683,"asset_id":16361360,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42511683/download_file?st=MTczMzk4ODM4Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35485628" href="https://vetmeduni.academia.edu/RMoriggl">R. Moriggl</a><script data-card-contents-for-user="35485628" type="text/json">{"id":35485628,"first_name":"R.","last_name":"Moriggl","domain_name":"vetmeduni","page_name":"RMoriggl","display_name":"R. Moriggl","profile_url":"https://vetmeduni.academia.edu/RMoriggl","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16361360 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16361360"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16361360, container: ".js-paper-rank-work_16361360", }); });</script></li><li class="js-percentile-work_16361360 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16361360; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16361360"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16361360 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16361360"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16361360; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16361360]").text(description); $(".js-view-count-work_16361360").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16361360").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16361360"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="14109" href="https://www.academia.edu/Documents/in/Leukemia">Leukemia</a>, <script data-card-contents-for-ri="14109" type="text/json">{"id":14109,"name":"Leukemia","url":"https://www.academia.edu/Documents/in/Leukemia","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23066" href="https://www.academia.edu/Documents/in/DNA_damage">DNA damage</a>, <script data-card-contents-for-ri="23066" type="text/json">{"id":23066,"name":"DNA damage","url":"https://www.academia.edu/Documents/in/DNA_damage","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="24731" href="https://www.academia.edu/Documents/in/Apoptosis">Apoptosis</a>, <script data-card-contents-for-ri="24731" type="text/json">{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a><script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16361360]'), work: {"id":16361360,"title":"The role of Stat5 transcription factors as tumor suppressors or oncogenes","created_at":"2015-10-01T06:43:57.273-07:00","owner_id":35485628,"url":"https://www.academia.edu/16361360/The_role_of_Stat5_transcription_factors_as_tumor_suppressors_or_oncogenes","slug":"The_role_of_Stat5_transcription_factors_as_tumor_suppressors_or_oncogenes","dom_id":"work_16361360","summary":null,"publication":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","publication_with_fallback":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","downloadable_attachments":[{"id":42511683,"asset_id":16361360,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42511683/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42511683/j.bbcan.2010.10.004-libre.pdf20160209-28316-jdrfr6?1455058272=\u0026response-content-disposition=attachment%3B+filename%3DThe_role_of_Stat5_transcription_factors.pdf\u0026Expires=1733282899\u0026Signature=Lca91fS6PTI14eqhhyTgVs3OjoqIjDb0dy8VAcKr0PfudCrt0eT6CtDzyHLPWMvIYlRRMwroAZD0d2ICVlUrtH6hvvt0MCYwfiFfSeRDo8lmyuznalbirz7wFfYwGDH4RcEVsO9NTyXBngwQ8WHitp29pay-gnKX4VGjvZ628Nq1Q-2ffup~2A7L8XUnxj8w1H~rXVao-jTSYLiN5iEs2JcLeSR9v1vLVV79WzAYooatBfVfDurZzle4egtpybKWgr~eUSropCQ6i-FKrlVoBK3QRDK6q~vViv0esSIbbfTJ8RiUY9b254NtDUtIZzlGAien7l146X1PrvzuSl1UIA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42511683/download_file?st=MTczMzk4ODM4Myw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42511683/mini_magick20190217-31038-1lgtse4.png?1550441920"}],"downloadable_attachments_with_full_thumbnails":[{"id":42511683,"asset_id":16361360,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42511683/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42511683/j.bbcan.2010.10.004-libre.pdf20160209-28316-jdrfr6?1455058272=\u0026response-content-disposition=attachment%3B+filename%3DThe_role_of_Stat5_transcription_factors.pdf\u0026Expires=1733282899\u0026Signature=Lca91fS6PTI14eqhhyTgVs3OjoqIjDb0dy8VAcKr0PfudCrt0eT6CtDzyHLPWMvIYlRRMwroAZD0d2ICVlUrtH6hvvt0MCYwfiFfSeRDo8lmyuznalbirz7wFfYwGDH4RcEVsO9NTyXBngwQ8WHitp29pay-gnKX4VGjvZ628Nq1Q-2ffup~2A7L8XUnxj8w1H~rXVao-jTSYLiN5iEs2JcLeSR9v1vLVV79WzAYooatBfVfDurZzle4egtpybKWgr~eUSropCQ6i-FKrlVoBK3QRDK6q~vViv0esSIbbfTJ8RiUY9b254NtDUtIZzlGAien7l146X1PrvzuSl1UIA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42511683/download_file?st=MTczMzk4ODM4Myw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42511683/mini_magick20190217-31038-1lgtse4.png?1550441920"}],"has_pdf":true,"has_fulltext":true,"page_count":11,"ordered_authors":[{"id":35485628,"first_name":"R.","last_name":"Moriggl","domain_name":"vetmeduni","page_name":"RMoriggl","display_name":"R. Moriggl","profile_url":"https://vetmeduni.academia.edu/RMoriggl","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":14109,"name":"Leukemia","url":"https://www.academia.edu/Documents/in/Leukemia","nofollow":false},{"id":23066,"name":"DNA damage","url":"https://www.academia.edu/Documents/in/DNA_damage","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":118582,"name":"Physical sciences","url":"https://www.academia.edu/Documents/in/Physical_sciences"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":280879,"name":"Mitochondrial dysfunction","url":"https://www.academia.edu/Documents/in/Mitochondrial_dysfunction"},{"id":323415,"name":"Mouse Model","url":"https://www.academia.edu/Documents/in/Mouse_Model"},{"id":338613,"name":"Oncogenes","url":"https://www.academia.edu/Documents/in/Oncogenes"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1579513,"name":"Tumor Progression","url":"https://www.academia.edu/Documents/in/Tumor_Progression"}],"publication_year":2011,"publication_year_with_fallback":2011,"paper_rank":null,"all_time_views":74,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16361361" data-work_id="16361361" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16361361/STAT1_acts_as_a_tumor_promoter_for_leukemia_development">STAT1 acts as a tumor promoter for leukemia development</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">. STAT1 -/-B cell precursors are susceptible to v-abl transformation A: STAT1 +/and STAT1 -/fetal liver cells were stained for B cell precursors that represent targets for the v-abl retrovirus. The percentages of CD19 + /CD43 + cells were... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16361361" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">. STAT1 -/-B cell precursors are susceptible to v-abl transformation A: STAT1 +/and STAT1 -/fetal liver cells were stained for B cell precursors that represent targets for the v-abl retrovirus. The percentages of CD19 + /CD43 + cells were found comparable (one representative example is given). STAT1 +/and STAT1 -/littermate fetal liver derived cells were infected with v-abl and maintained in growth factor-free methylcellulose. Colonies are depicted in B and quantified in C. Data represent mean ± SD. Colony size of outgrowing pro-B cells from one representative STAT1 +/and STAT1 -/preparation is depicted (D). Gel shift assays (lanes 1) and supershift assays for Stat1 (lanes 2) and Stat3 (lanes 3) show activation of STAT1 and STAT3 in v-abl transformed cells (E).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16361361" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f5edf7972bd8f755085a0e49a663a158" rel="nofollow" data-download="{"attachment_id":42511686,"asset_id":16361361,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42511686/download_file?st=MTczMzk4ODM4NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35485628" href="https://vetmeduni.academia.edu/RMoriggl">R. Moriggl</a><script data-card-contents-for-user="35485628" type="text/json">{"id":35485628,"first_name":"R.","last_name":"Moriggl","domain_name":"vetmeduni","page_name":"RMoriggl","display_name":"R. Moriggl","profile_url":"https://vetmeduni.academia.edu/RMoriggl","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16361361 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16361361"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16361361, container: ".js-paper-rank-work_16361361", }); });</script></li><li class="js-percentile-work_16361361 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16361361; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16361361"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16361361 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16361361"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16361361; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16361361]").text(description); $(".js-view-count-work_16361361").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16361361").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16361361"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3642" href="https://www.academia.edu/Documents/in/Stem_Cells">Stem Cells</a>, <script data-card-contents-for-ri="3642" type="text/json">{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="70247" href="https://www.academia.edu/Documents/in/Natural_Killer_cells">Natural Killer cells</a>, <script data-card-contents-for-ri="70247" type="text/json">{"id":70247,"name":"Natural Killer cells","url":"https://www.academia.edu/Documents/in/Natural_Killer_cells","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="84760" href="https://www.academia.edu/Documents/in/Mice">Mice</a><script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16361361]'), work: {"id":16361361,"title":"STAT1 acts as a tumor promoter for leukemia development","created_at":"2015-10-01T06:43:57.399-07:00","owner_id":35485628,"url":"https://www.academia.edu/16361361/STAT1_acts_as_a_tumor_promoter_for_leukemia_development","slug":"STAT1_acts_as_a_tumor_promoter_for_leukemia_development","dom_id":"work_16361361","summary":". STAT1 -/-B cell precursors are susceptible to v-abl transformation A: STAT1 +/and STAT1 -/fetal liver cells were stained for B cell precursors that represent targets for the v-abl retrovirus. The percentages of CD19 + /CD43 + cells were found comparable (one representative example is given). STAT1 +/and STAT1 -/littermate fetal liver derived cells were infected with v-abl and maintained in growth factor-free methylcellulose. Colonies are depicted in B and quantified in C. Data represent mean ± SD. Colony size of outgrowing pro-B cells from one representative STAT1 +/and STAT1 -/preparation is depicted (D). Gel shift assays (lanes 1) and supershift assays for Stat1 (lanes 2) and Stat3 (lanes 3) show activation of STAT1 and STAT3 in v-abl transformed cells (E).","publication":"Cancer Cell","publication_with_fallback":"Cancer Cell","downloadable_attachments":[{"id":42511686,"asset_id":16361361,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42511686/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42511686/STAT1_acts_as_a_tumor_promoter_for_leuke20160209-26039-30xzus-libre.pdf?1455058272=\u0026response-content-disposition=attachment%3B+filename%3DSTAT1_acts_as_a_tumor_promoter_for_leuke.pdf\u0026Expires=1733991984\u0026Signature=fi8mNLo-2f-lkR-pUIauGwbN1lEgAaBFPOn6CksGeDx8oX197Cnf1oaEYCOS-JzYjsH0T9qDJ1htyc9KrqAO2Q~YhjbHhObd~OB8M0lEaG26j3~4kYCWF7IfJ9-0CsmJ8NVw3A0jDsdMpobdhU2eQkA-z~UKQaTNort3G7jW9YmBiU6-psBVusYSSQEN4igUnY1r88YpRT0r~w~CqBq8pM-hjyPDVRpkNS-~3916wSdhld1cOz-a04GZGK98VZfi3p235fIOvo31Nz7z2WmGwD1s1IGViXaJR1kosVrQD4PRDljzrO02EkerOEACALbcKhRjTX5o2I6Lhj66t5a7Dg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42511686/download_file?st=MTczMzk4ODM4NCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42511686/mini_magick20190217-2731-15ky25z.png?1550441927"}],"downloadable_attachments_with_full_thumbnails":[{"id":42511686,"asset_id":16361361,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42511686/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42511686/STAT1_acts_as_a_tumor_promoter_for_leuke20160209-26039-30xzus-libre.pdf?1455058272=\u0026response-content-disposition=attachment%3B+filename%3DSTAT1_acts_as_a_tumor_promoter_for_leuke.pdf\u0026Expires=1733991984\u0026Signature=fi8mNLo-2f-lkR-pUIauGwbN1lEgAaBFPOn6CksGeDx8oX197Cnf1oaEYCOS-JzYjsH0T9qDJ1htyc9KrqAO2Q~YhjbHhObd~OB8M0lEaG26j3~4kYCWF7IfJ9-0CsmJ8NVw3A0jDsdMpobdhU2eQkA-z~UKQaTNort3G7jW9YmBiU6-psBVusYSSQEN4igUnY1r88YpRT0r~w~CqBq8pM-hjyPDVRpkNS-~3916wSdhld1cOz-a04GZGK98VZfi3p235fIOvo31Nz7z2WmGwD1s1IGViXaJR1kosVrQD4PRDljzrO02EkerOEACALbcKhRjTX5o2I6Lhj66t5a7Dg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42511686/download_file?st=MTczMzk4ODM4NCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42511686/mini_magick20190217-2731-15ky25z.png?1550441927"}],"has_pdf":true,"has_fulltext":true,"page_count":6,"ordered_authors":[{"id":35485628,"first_name":"R.","last_name":"Moriggl","domain_name":"vetmeduni","page_name":"RMoriggl","display_name":"R. Moriggl","profile_url":"https://vetmeduni.academia.edu/RMoriggl","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells","nofollow":false},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis","nofollow":false},{"id":70247,"name":"Natural Killer cells","url":"https://www.academia.edu/Documents/in/Natural_Killer_cells","nofollow":false},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice","nofollow":false},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":372410,"name":"Genotype","url":"https://www.academia.edu/Documents/in/Genotype"},{"id":506082,"name":"Cancer Cell","url":"https://www.academia.edu/Documents/in/Cancer_Cell"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1186610,"name":"DNA binding proteins","url":"https://www.academia.edu/Documents/in/DNA_binding_proteins"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":2058663,"name":"Interferon gamma","url":"https://www.academia.edu/Documents/in/Interferon_gamma"}],"publication_year":2006,"publication_year_with_fallback":2006,"paper_rank":null,"all_time_views":14,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16361363 coauthored" data-work_id="16361363" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16361363/Sensitized_phenotypic_screening_identifies_gene_dosage_sensitive_region_on_chromosome_11_that_predisposes_to_disease_in_mice">Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16361363" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="cd10c21d506eb5ae2a8de09ebe12cd33" rel="nofollow" data-download="{"attachment_id":42511696,"asset_id":16361363,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42511696/download_file?st=MTczMzk4ODM4NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35485628" href="https://vetmeduni.academia.edu/RMoriggl">R. Moriggl</a><script data-card-contents-for-user="35485628" type="text/json">{"id":35485628,"first_name":"R.","last_name":"Moriggl","domain_name":"vetmeduni","page_name":"RMoriggl","display_name":"R. Moriggl","profile_url":"https://vetmeduni.academia.edu/RMoriggl","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16361363">+1</span><div class="hidden js-additional-users-16361363"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/LuisaLuciani">Luisa Luciani</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16361363'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16361363').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_16361363 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16361363"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16361363, container: ".js-paper-rank-work_16361363", }); });</script></li><li class="js-percentile-work_16361363 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16361363; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16361363"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16361363 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16361363"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16361363; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16361363]").text(description); $(".js-view-count-work_16361363").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16361363").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16361363"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="8015" href="https://www.academia.edu/Documents/in/Atherosclerosis">Atherosclerosis</a>, <script data-card-contents-for-ri="8015" type="text/json">{"id":8015,"name":"Atherosclerosis","url":"https://www.academia.edu/Documents/in/Atherosclerosis","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="38676" href="https://www.academia.edu/Documents/in/Anxiety">Anxiety</a>, <script data-card-contents-for-ri="38676" type="text/json">{"id":38676,"name":"Anxiety","url":"https://www.academia.edu/Documents/in/Anxiety","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="84760" href="https://www.academia.edu/Documents/in/Mice">Mice</a><script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16361363]'), work: {"id":16361363,"title":"Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice","created_at":"2015-10-01T06:43:57.681-07:00","owner_id":35485628,"url":"https://www.academia.edu/16361363/Sensitized_phenotypic_screening_identifies_gene_dosage_sensitive_region_on_chromosome_11_that_predisposes_to_disease_in_mice","slug":"Sensitized_phenotypic_screening_identifies_gene_dosage_sensitive_region_on_chromosome_11_that_predisposes_to_disease_in_mice","dom_id":"work_16361363","summary":null,"publication":"EMBO Molecular Medicine","publication_with_fallback":"EMBO Molecular Medicine","downloadable_attachments":[{"id":42511696,"asset_id":16361363,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42511696/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42511696/Sensitized_phenotypic_screening_identifi20160209-7817-tni6bq-libre.pdf?1455058273=\u0026response-content-disposition=attachment%3B+filename%3DSensitized_phenotypic_screening_identifi.pdf\u0026Expires=1733991984\u0026Signature=gjsaHxOb7Hp0DD3Jw3FiLszzr1q4SZJ6GxDz5YJoQsPqYYA-hLwrtmuw3Byq5p~NqturRFKSToqT750SyUM204ykOh6MIZw0BOdEySsB5aAz9hxgL1YLyjLmFrYduEL4~Rq84VK4s10BKq09~CnnWoDx~62c5D7PpB5eBEPh-9JhsiNDHcqcH1KQgGqQhpQCleT0TBgElMwegRb23pVkX6n-jQheq7qfLuTb5FJphM1NSukOBBbO6jy1-gRLwGK5bbSvgRQnizBvfraqbXvkEx0A3Svqe-M-Q-WV8mLP1dV9ITE8Rv6KzoEpfu-SYArZOFZVB2rCyPNWPg-m5N5AMA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42511696/download_file?st=MTczMzk4ODM4NCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42511696/mini_magick20190217-4229-p5e6a8.png?1550441964"}],"downloadable_attachments_with_full_thumbnails":[{"id":42511696,"asset_id":16361363,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/42511696/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/42511696/Sensitized_phenotypic_screening_identifi20160209-7817-tni6bq-libre.pdf?1455058273=\u0026response-content-disposition=attachment%3B+filename%3DSensitized_phenotypic_screening_identifi.pdf\u0026Expires=1733991984\u0026Signature=gjsaHxOb7Hp0DD3Jw3FiLszzr1q4SZJ6GxDz5YJoQsPqYYA-hLwrtmuw3Byq5p~NqturRFKSToqT750SyUM204ykOh6MIZw0BOdEySsB5aAz9hxgL1YLyjLmFrYduEL4~Rq84VK4s10BKq09~CnnWoDx~62c5D7PpB5eBEPh-9JhsiNDHcqcH1KQgGqQhpQCleT0TBgElMwegRb23pVkX6n-jQheq7qfLuTb5FJphM1NSukOBBbO6jy1-gRLwGK5bbSvgRQnizBvfraqbXvkEx0A3Svqe-M-Q-WV8mLP1dV9ITE8Rv6KzoEpfu-SYArZOFZVB2rCyPNWPg-m5N5AMA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/42511696/download_file?st=MTczMzk4ODM4NCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/42511696/mini_magick20190217-4229-p5e6a8.png?1550441964"}],"has_pdf":true,"has_fulltext":true,"page_count":17,"ordered_authors":[{"id":35485628,"first_name":"R.","last_name":"Moriggl","domain_name":"vetmeduni","page_name":"RMoriggl","display_name":"R. Moriggl","profile_url":"https://vetmeduni.academia.edu/RMoriggl","photo":"/images/s65_no_pic.png"},{"id":43069888,"first_name":"Luisa","last_name":"Luciani","domain_name":"independent","page_name":"LuisaLuciani","display_name":"Luisa Luciani","profile_url":"https://independent.academia.edu/LuisaLuciani","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":8015,"name":"Atherosclerosis","url":"https://www.academia.edu/Documents/in/Atherosclerosis","nofollow":false},{"id":38676,"name":"Anxiety","url":"https://www.academia.edu/Documents/in/Anxiety","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice","nofollow":false},{"id":138959,"name":"Aneuploidy","url":"https://www.academia.edu/Documents/in/Aneuploidy"},{"id":194433,"name":"Gene Dosage","url":"https://www.academia.edu/Documents/in/Gene_Dosage"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":623821,"name":"ANXIETY","url":"https://www.academia.edu/Documents/in/ANXIETY-1"},{"id":1015202,"name":"Hypersensitivity","url":"https://www.academia.edu/Documents/in/Hypersensitivity"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"}],"publication_year":2011,"publication_year_with_fallback":2011,"paper_rank":null,"all_time_views":9,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div></div></div><div class="u-taCenter Pagination"></div></div></div></div></div></div></div> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "27dda2288dc026acaf02d2a21abfe7c33505f362c31ea066e6a49a372abe32eb", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="73OiqGpKcfh+ul0IH0TsGIsWfMeV6tXoLzlG9kwECtmCz4sH7jcYOjZrd3L+eJZb59T2TqRtc2CLbNWNCO5/ew==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://vetmeduni.academia.edu/Departments/Functional_Cancer_Genomics/Documents" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="HxbgWOFvITosCQGToHieKdXOMPV3sjaiLF1SaxUB7yhyqsn3ZRJI+GTYK+lBRORquQy6fEY1kCqICMEQUeuaig==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style=""><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style=""><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>