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Transplant Immunology | UCSF Department of Surgery
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aria-labelledby="system-breadcrumb"> <span id="system-breadcrumb" class="visually-hidden" tabindex="0">Breadcrumb</span> <div class="breadcrumbs__container"> <ol class="breadcrumbs__list"> <li class="breadcrumbs__item"> <a class="breadcrumbs__link" href="/">Home</a> </li> <span class="breadcrumbs__spacer">/</span> <li class="breadcrumbs__item"> Transplant Immunology </li> </ol> </div> </nav> </div> </div> <div class="main l-content right-sidebar-only"> <div class="page-content-outer-wrap"> <div class="region region-title"> <div id="block-dos-page-title" class="block block-core block-page-title-block"> <h1 class="page-title"><span class="field field--name-title field--type-string field--label-hidden">Transplant Immunology</span> </h1> </div> </div> <div class="page-content-inner-wrap"> <div class="page-content"> <div class="region region-content"> <div id="block-dos-content" class="block block-system block-system-main-block"> <article data-history-node-id="132511" class="node node--type-research node--view-mode-full"> <div class="node__content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Organ transplantation is often the only clinical option available for treating certain types of cardiovascular disease. While frequently successfully performed, organ transplantation is often accompanied by immune system complications that result in rejection. The TSI Lab is highly motivated toward designing methods to help prevent such rejection, ranging from investigating the immunogenicity of matrix components of bioengineered tissue for transplantation (Conradi et al. 2015), to use of techniques that allow visualization of immune responses after transplantation (Conradi et al. 2011), to identifying novel immunosuppressants for prevention of acute cardiac graft rejection (Deuse et al. 2012). The TSI Lab continues to develop new concepts to identify and prevent immune rejection post-transplantion.</p><h4>Related Publications</h4><div>Conradi L, Pahrmann C, Schmidt S, Deuse T, Hansen A, Eder A, Reichenspurner H, Robbins RC, Eschenhagen T, Schrepfer S </div><div><strong>Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT).</strong><em><strong> </strong></em></div><div><em>Journal of visualized experiments</em> : JoVE, 2011;[epublish](52).</div><div><a>View Abstract</a> | <a href="http://www.ncbi.nlm.nih.gov/pubmed/21673633" target="_blank">PubMed AbstractPlus</a></div><p> </p><div>Conradi L, Schmidt S, Neofytou E, Deuse T, Peters L, Eder A, Hua X, Hansen A, Robbins RC, Beygui RE, Reichenspurner H, Eschenhagen T, Schrepfer S </div><div><strong>Immunobiology of fibrin-based engineered heart tissue.</strong><em><strong> </strong></em></div><div><em>Stem cells translational medicine</em>, Jun-2015;4(6):625-31. Epub 2015 May 6.</div><div><a>View Abstract</a> | <a href="http://www.ncbi.nlm.nih.gov/pubmed/25947338" target="_blank">PubMed AbstractPlus</a></div><div><br>Deuse T, Hua X, Taylor V, Stubbendorff M, Baluom M, Chen Y, Park G, Velden J, Streichert T, Reichenspurner H, Robbins RC, Schrepfer S </div><div><strong>Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545. </strong></div><div><em>Transplantation</em>, Oct-15-2012;94(7):695-702.</div><div><a>View Abstract</a> | <a href="http://www.ncbi.nlm.nih.gov/pubmed/22971540" target="_blank">PubMed AbstractPlus</a></div></div> </div> </article> </div> <div id="block-dos-researchconetnttypecss" class="research-css-changes block block-block-content block-block-content7eede32a-991e-498b-843b-5f403ee2365b"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style> /* make h1 tag a bit smaller since this is long h1 */ @media (min-width: 64em) { .h1, h1 { font-size: 3.05rem !important; } } @media (min-width: 57.5em) { body:not(.page-is-fullwidth) .main.l-content.right-sidebar-only { flex-direction: row; max-width: 57em; } } </style></div> </div> </div> </div> </div> </div> <aside id="sidebar-right" class="sidebar-second" role="complementary"> <div class="region region-sidebar-right"> <div class="views-element-container block block-views block-views-blocksidebar-components-block-1" id="block-views-block-sidebar-components-block-1"> <div region="sidebar_right"><div class="view view-sidebar-components view-id-sidebar_components view-display-id-block_1 js-view-dom-id-63271b173519eba6e92a96bd49d129269b1bf38012e06b933ca8c249cde9eb00"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-sidebar-components"><div class="field-content"></div></div></div> </div> </div> </div> </div> <div class="views-element-container block block-views block-views-blockresearch-research-bios-rightbar-block" id="block-dos-views-block-research-research-bios-rightbar-block"> <h2>Associated Bios</h2> <div region="sidebar_right"><div class="associated-bios-block view view-research view-id-research view-display-id-research_bios_rightbar_block js-view-dom-id-a4643a474acaec4bd8795c25a9fc8ea6234eb95859b2f4c13362b9de71e54d79"> <div class="view-header"> <style>.associated-publications {margin-top:15px;} .associated-conditions-procedures {margin-top:15px;} .associated-physicians {margin-top:15px;} .item-research-body a { display: inline-block !important; font-size: 1rem !important; } .views-label.views-label-field-related-links a { text-decoration: none; color: #0f388a; cursor: auto; pointer-events: none; } .related-bio-row.views-row img { width: 55%; padding: 12px; text-align:center; } .research-rightbar-bio-img { background: linear-gradient(to bottom, #052049 0, rgba(22, 160, 172, 0.5) 50%, rgba(22, 160, 172, 0) 100%) !important; margin-bottom: 2rem; text-align: center; font-size: 1.3rem; } .field-content.rightbar-research-bio-image { font-size: 1.2rem; padding: 0 15px; } .associated-bios-block { margin-bottom:1rem;} .research-rightbar-assoc-bios {margin-bottom:2rem !important;} .field-content.research-rightbar-bios { font-weight: bold; padding: 10px; } .related-bio-row.views-row { border: 1px solid #7e92ae; border-bottom-right-radius: 40px; line-height: 1.25; margin-bottom: 1.25rem; } .research-rightbar-bio-text {font-size:1.25rem; margin: 1.25rem;} .research-rightbar-bios-title {font-size: 1.5rem; font-weight: bold; margin: 1.25rem;} .rightbar-elements { border-bottom-right-radius: 40px; border: 1px solid #7e92ae; } .rightbar-elements h2 { margin: 10px; font-size: 1.5rem; } .research-rightbar-bio-text br { margin-bottom: 8px; } </style> </div> <div class="view-content"> <div class="related-bio-row views-row"><div class="views-field views-field-field-primary-image"><div class="field-content research-rightbar-bio-img"> <img loading="lazy" src="/sites/default/files/styles/kan_thumbnail/public/2024-10/Deuse-headshot-revised-144x192.webp?itok=a0i9XDpy" width="144" height="192" alt="Deuse headshot 144x192" class="image-style-kan-thumbnail" /> </div></div><div class="views-field views-field-title"><div class="field-content research-rightbar-bios-title"><a href="/bio/tobias-deuse" hreflang="en">Tobias Deuse, MD</a></div></div><div class="views-field views-field-field-academic-working-titles"><div class="field-content research-rightbar-bio-text"> <p>Professor of Surgery, UCSF<br>Division of Cardiothoracic Surgery<br>The Julien I.E. 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