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views-slideshow-controls-text-status-play"><a href="#">Pause</a></span> <span id="views_slideshow_controls_text_next_slider-slider_block_1" class="views-slideshow-controls-text-next views_slideshow_controls_text_next"> <a href="#" rel="next">Next</a> </span> </div> </div> </div> </div> </div> <h1>Valerie M. Weaver Lab</h1>  <article class="node node-page " about="/valerie-m-weaver-lab" typeof="sioc:Item foaf:Document" role="article"> <span property="dc:title" content="Valerie M. Weaver Lab" class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <footer class="article-meta"> </footer> <div class="content"> <div class="field field-type-text-with-summary field-label-hidden field-name-body"> <p>Stromal-epithelial interactions regulate tissue development and homeostasis. In particular, the extracellular matrix, which is the noncellular component of the microenvironment, influences cell growth, survival, migration and tissue-specific differentiation through a repertoire of cellular receptors including integrins, syndecans and discoidin receptors. My group is exploring the molecular mechanisms whereby these extracellular matrix receptors modulate cell fate. Specifically, we are investigating how mechanical and topological properties of the matrix, which are related to its composition and organization, regulate the function of matrix receptors to alter cell behavior. Our research program is broadly divided into two fields of inquiry. The first focuses on understanding how matrix composition and organization influences mammary tissue development and tumor progression, and the second aims to clarify the role of matrix force on embryonic and adult stem cell fate.</p> </div> </div> </article> </div> <div class="sidebar-second col"> <div class="block block-views "> <h2 class="title">News</h2> <div class="view-id-news view-display-id-news_block view-dom-id-6f704f1853f6184972730be295aa9982"> <div class="views-row"> <div class="views-field views-field-created"> <span class="field-content">May 29, 2018</span> </div> <div class="views-field views-field-field-image"> <div class="field-content"><a href="/news/physical-and-biochemical-properties-extracellular-matrix-regulate-cell-fate"><img typeof="foaf:Image" src="/sites/weaverlab.ucsf.edu/files/styles/ucsf_square_thumbnail/public/field/image/news/1-s2.0-S0070215318300346-f01-01-9780128098028.jpg?itok=RqSK4yP9" alt="" /></a></div> </div> <div class="views-field views-field-body"> <div class="field-content"><p>Read our new chapter in Current Topics in Developmental Biology. </p> <p><a href="https://authors.elsevier.com/b/1X7ThFzn76kQw">https://authors.elsevier.com/b/1X7ThFzn76kQw</a></p> <p> </p></div> </div> <div class="views-field views-field-view-node"> <span class="field-content"><a href="/news/physical-and-biochemical-properties-extracellular-matrix-regulate-cell-fate">view</a></span> </div> </div> <div class="views-row"> <div class="views-field views-field-created"> <span class="field-content">June 23, 2016</span> </div> <div class="views-field views-field-field-image"> <div class="field-content"><a href="/news/super-resolution-imaging-platform-published-integrative-biology"><img typeof="foaf:Image" src="/sites/weaverlab.ucsf.edu/files/styles/ucsf_square_thumbnail/public/field/image/news/2016_05_14_Integrative_Biology_Figures_Revision6_Summary_Summary.png?itok=bCu1AMgo" alt="" /></a></div> </div> <div class="views-field views-field-body"> <div class="field-content"><p>Congratulations to Guanqing Ou and coauthors on their publication in <em>Integrative Biology</em>!</p></div> </div> <div class="views-field views-field-view-node"> <span class="field-content"><a href="/news/super-resolution-imaging-platform-published-integrative-biology">view</a></span> </div> </div> <div class="views-row"> <div class="views-field views-field-created"> <span class="field-content">April 19, 2016</span> </div> <div class="views-field views-field-field-image"> <div class="field-content"></div> </div> <div class="views-field views-field-body"> <div class="field-content"><p>UCSF news recently highlighted our publication in Nature Medicine:</p> <p><a href="https://www.ucsf.edu/news/2016/04/402431/gene-mutation-makes-tumors-tense-worsens-patient-prognosis">Gene Mutation Makes Tumors Tense, Worsens Patient Prognosis</a></p></div> </div> <div class="views-field views-field-view-node"> <span class="field-content"><a href="/news/nature-medicine-publication-featured-ucsf-news">view</a></span> </div> </div> <h2 class="element-invisible">Pages</h2><ul class="pager"><li class="pager-current first">1</li> <li class="pager-item"><a title="Go to page 2" href="/valerie-m-weaver-lab?page=1">2</a></li> <li class="pager-item"><a title="Go to page 3" href="/valerie-m-weaver-lab?page=2">3</a></li> <li class="pager-item"><a title="Go to page 4" href="/valerie-m-weaver-lab?page=3">4</a></li> <li class="pager-item"><a title="Go to page 5" href="/valerie-m-weaver-lab?page=4">5</a></li> <li class="pager-item"><a title="Go to page 6" href="/valerie-m-weaver-lab?page=5">6</a></li> <li class="pager-item"><a title="Go to page 7" href="/valerie-m-weaver-lab?page=6">7</a></li> <li class="pager-item"><a title="Go to page 8" href="/valerie-m-weaver-lab?page=7">8</a></li> <li class="pager-item"><a title="Go to page 9" href="/valerie-m-weaver-lab?page=8">9</a></li> <li class="pager-ellipsis">…</li> <li class="pager-next"><a href="/valerie-m-weaver-lab?page=1">›</a></li> <li class="pager-last last"><a href="/valerie-m-weaver-lab?page=10">»</a></li> </ul> <div class="more-link"> <a href="/news"> See all </a> </div> </div> </div> <div class="block block-views "> <h2 class="title">Key Publications</h2> <div class="view-key-publications- view-id-key_publications_ view-display-id-block view-dom-id-3a0116f7d2be1596a041971d0e48e2ee"> <div class="views-row"> <div class="views-field views-field-title"> <span class="field-content"><a href="/content/tissue-mechanics-modulate-microrna-dependent-pten-expression-regulate-malignant-progression">Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.</a></span> </div> <div class="views-field views-field-biblio-date"> <span class="field-content">2014 Mar 16</span> </div> </div> <div class="views-row"> <div class="views-field views-field-title"> <span class="field-content"><a href="/content/cancer-glycocalyx-mechanically-primes-integrin-mediated-growth-and-survival">The cancer glycocalyx mechanically primes integrin-mediated growth and survival.</a></span> </div> <div class="views-field views-field-biblio-date"> <span class="field-content">2014 Jul 17</span> </div> </div> <div class="views-row"> <div class="views-field views-field-title"> <span class="field-content"><a href="/content/oncogenic-targeting-brm-drives-malignancy-through-cebp%CE%B2-dependent-induction-%CE%B15-integrin">Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.</a></span> </div> <div class="views-field views-field-biblio-date"> <span class="field-content">2013 Jun 17</span> </div> </div> <div class="views-row"> <div class="views-field views-field-title"> <span class="field-content"><a href="/content/hoxa9-regulates-brca1-expression-modulate-human-breast-tumor-phenotype">HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.</a></span> </div> <div class="views-field views-field-biblio-date"> <span class="field-content">2010 May</span> </div> </div> <div class="views-row"> <div class="views-field views-field-title"> <span class="field-content"><a href="/content/matrix-crosslinking-forces-tumor-progression-enhancing-integrin-signaling">Matrix crosslinking forces tumor progression by enhancing integrin signaling.</a></span> </div> <div class="views-field views-field-biblio-date"> <span class="field-content">2009 Nov 25</span> </div> </div> <h2 class="element-invisible">Pages</h2><ul class="pager"><li class="pager-current first">1</li> <li class="pager-item"><a title="Go to page 2" href="/valerie-m-weaver-lab?page=1">2</a></li> <li class="pager-next"><a href="/valerie-m-weaver-lab?page=1">›</a></li> <li class="pager-last last"><a href="/valerie-m-weaver-lab?page=1">»</a></li> </ul> </div> </div> </div> </div> </div> </div> <div class="footer-container"> <footer role="contentinfo" class="row"> <div 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