TSILab - Homepage | UCSF Department of Surgery

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class="menu-item"> <a href="https://breastcaresurgery.ucsf.edu/">Breast Care Surgery</a> </li> <li class="menu-item"> <a href="https://cardiacsurgery.ucsf.edu/">Cardiac Surgery</a> </li> <li class="menu-item"> <a href="https://herniacenter.ucsf.edu/">Center for Hernia Repair & Abdominal Wall Reconstruction</a> </li> <li class="menu-item"> <a href="https://limbpreservation.ucsf.edu/">Center for Limb Preservation & Diabetic Foot</a> </li> <li class="menu-item"> <a href="https://geriatricsurgery.ucsf.edu/">Center for Surgery in Older Adults</a> </li> <li class="menu-item"> <a href="https://colorectalsurgery.ucsf.edu/">Colorectal Surgery</a> </li> <li class="menu-item"> <a href="https://endocrinesurgery.ucsf.edu/">Endocrine Surgery</a> </li> <li class="menu-item"> <a href="https://eras.ucsf.edu/">Enhanced Recovery After Surgery (ERAS)</a> </li> <li class="menu-item"> <a href="https://surgery.ucsf.edu/list-of-external-sites/fetal-treatment-center">Fetal Treatment Center</a> </li> <li 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Training</span> </h2> <ul class="menu"> <li class="menu-item"> <a href="https://transplantfellowship.ucsf.edu/">Abdominal Transplant Fellowship</a> </li> <li class="menu-item"> <a href="https://surgeryfap.ucsf.edu/">Faculty Affairs & Development Portal</a> </li> <li class="menu-item"> <a href="https://medstudentsurgery.ucsf.edu/">Medical Student Portal</a> </li> <li class="menu-item"> <a href="https://murielsteelesociety.ucsf.edu/">Muriel Steele Society</a> </li> <li class="menu-item"> <a href="https://plasticsurgeryresidency.ucsf.edu/">Plastic Surgery Residency</a> </li> <li class="menu-item"> <a href="https://surgeryresidentportal.ucsf.edu/">Resident Portal</a> </li> <li class="menu-item"> <a href="https://surgeryresidentresearch.ucsf.edu/">Resident Research</a> </li> <li class="menu-item"> <a href="https://npfellowship.ucsf.edu/">Surgical & Critical Care NP Fellowship</a> </li> <li class="menu-item"> <a href="https://surgeryeducation.ucsf.edu/">Surgery Education Portal</a> </li> <li 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Websites</span> </h2> <ul class="menu"> <li class="menu-item"> <a href="https://raffailab.ucsf.edu/">Atherosclerosis Research Lab</a> </li> <li class="menu-item"> <a href="https://surgerybiostat.ucsf.edu/">Biostatistics Core</a> </li> <li class="menu-item"> <a href="https://cardiacbiomechanicslab.ucsf.edu/">Cardiac Biomechanics Lab</a> </li> <li class="menu-item"> <a href="https://mindfulsurgeon.ucsf.edu/">Center for Mindfulness in Surgery</a> </li> <li class="menu-item"> <a href="https://livertissueengineering.ucsf.edu/">Chang Laboratory for Liver Tissue Engineering</a> </li> <li class="menu-item"> <a href="https://contelab.ucsf.edu/">Conte Lab</a> </li> <li class="menu-item"> <a href="https://endocrineneoplasialab.ucsf.edu/">Endocrine Neoplasia Research Lab</a> </li> <li class="menu-item"> <a href="https://itl.ucsf.edu/">Immunogenetics & Transplantation Lab</a> </li> <li class="menu-item"> <a href="https://kornblithlab.ucsf.edu/">Kornblith Lab</a> </li> <li class="menu-item"> <a 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Lab</a> </li> <li class="menu-item"> <a href="https://toplab.ucsf.edu/">Thoracic Oncology Lab</a> </li> <li class="menu-item"> <a href="https://tsilab.ucsf.edu/">TSI Lab</a> </li> <li class="menu-item"> <a href="https://wanglaboratory.ucsf.edu/">Wang Lab</a> </li> <li class="menu-item"> <a href="https://weaverlab.ucsf.edu/">Weaver Lab</a> </li> <li class="menu-item"> <a href="https://willenbringlab.ucsf.edu/">Willenbring Lab</a> </li> </ul> </div> </li> </ul> </div> </nav> <div class="search-api-form block block-search container-inline hidden" data-drupal-selector="search-api-form" id="block-searchapiform-2"> <div class="search-form-modal-container"> <button class="dropdown-close dropdown-button">Close</button> <form region="mobile_menu" action="/search" method="get" id="search-api-form" accept-charset="UTF-8"> <div class="search-text-and-button-wrapper js-form-wrapper form-wrapper" data-drupal-selector="edit-search-text-and-button-wrapper" id="edit-search-text-and-button-wrapper"><div 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class="field field--name-field-heading field--type-string field--label-hidden field__item">The Transplant and Stem Cell Immunobiology (TSI) Laboratory </div> </div> <div class="body"> <div class="clearfix text-formatted field field--name-field-body field--type-text field--label-hidden field__item">UCSF Department of Surgery</div> </div> </div> </div> </div> </div> </div> </div> <div class="field__item column-tippi-pic"> <div > <div class="columns text-vert-align--top remove-top-padding columns--layout-sidebar-left paragraph paragraph--type--kan-columns paragraph--view-mode--default no-decor"> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <div><h3>Principal Investigators</h3></div><div class="principal-investigators"><div class="principal-investigator"> <article class="media media--type-image media--view-mode-rounded-overlay" aria-label="Image about Schrepfer "> <div class="corner-detail mobile"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="50px" height="50px" viewBox="0 0 50 50" style="enable-background:new 0 0 50 50;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,50 2.5,2.5 50,2.5 " /> </svg> </div> <div class="corner-detail desktop"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="100px" height="100px" viewBox="0 0 100 100" style="enable-background:new 0 0 100 100;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,100 2.5,2.5 100,2.5 " /> </svg> </div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/rounded_overlay/public/2023-10/schrepfer_354x210.jpg.webp?itok=7zEE0i0N" width="354" height="210" alt="Schrepfer " class="image-style-rounded-overlay"> </div> </article> <div><div class="text-container"><h3><a class="bio-title" href="/bio/sonja-schrepfer" rel="bookmark"><span class="field field--name-title field--type-string field--label-hidden">Sonja Schrepfer, MD, PhD</span></a></h3><div class="field field--name-field-academic-working-titles field--type-text-long field--label-hidden field__item"><p style="font-size:1rem;">Professor of Surgery, UCSF<br>Division of Cardiothoracic Surgery<br>Director, TSI Lab</p></div></div></div></div><div class="principal-investigator"> <article class="media media--type-image media--view-mode-rounded-overlay" aria-label="Image about Tobias Deuse"> <div class="corner-detail mobile"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="50px" height="50px" viewBox="0 0 50 50" style="enable-background:new 0 0 50 50;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,50 2.5,2.5 50,2.5 " /> </svg> </div> <div class="corner-detail desktop"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="100px" height="100px" viewBox="0 0 100 100" style="enable-background:new 0 0 100 100;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,100 2.5,2.5 100,2.5 " /> </svg> </div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/rounded_overlay/public/2023-10/dr-tobias-deuse-md-354X210.jpg.webp?itok=SPHrJNIQ" width="354" height="210" alt="Tobias Deuse" class="image-style-rounded-overlay"> </div> </article> <div><div class="text-container"><h3><a class="bio-title" href="/bio/tobias-deuse" rel="bookmark"><span class="field field--name-title field--type-string field--label-hidden">Tobias Deuse, MD</span></a></h3><div class="field field--name-field-academic-working-titles field--type-text-long field--label-hidden field__item"><p style="font-size:1rem;">Professor of Surgery, UCSF<br>Division of Cardiothoracic Surgery<br>The Julien I.E. Hoffman, M.D. Endowed Chair in Cardiac Surgery<br>Director, Minimally-invasive Cardiac Surgery<br>Surgical Director, Transcatheter Valve Program<br>Principal Investigator, TSI lab</p></div></div></div></div></div> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <h2>Stem Cell & Transplant Immunobiology, Cardiovascular Disease, Space Medicine</h2><div class="lab_content_textarea_top"><p>The Transplant and Stem Cell Immunobiology (TSI) Laboratory uses multiple research directions to answer complex questions about stem cell therapy, heart and lung transplantation, and cardiovascular disease. Our laboratory focuses on the immunogenicity of allogeneic stem cells, tissues, and organs, and is interested in designing methods to prevent immunological recognition and rejection of such materials.</p><p>We are also interested in better understanding and preventing mechanisms that result in cardiovascular disease. With topics that range from basic science (e.g. identifying novel molecules involved in pluripotent stem cell immunogenicity) to translational medicine (e.g. developing drugs that may be useful in reducing myointimal hyperplasia), we take a wide-angle approach to our research.</p><p>Currently, we are involved in exciting cardiovascular research funded by the National Aeronautics and Space Administration (NASA). In addition to our excellent team at UCSF, we also work closely both scientifically and collaboratively with <a href="http://www.tsi-lab.de" target="_blank">our sister laboratory</a> in Hamburg, Germany.</p><p class="less-height" style="padding-top:15px;"><a class="btn-outline-editor btn-secondary-outline-editor" href="/tsilab-about-the-lab-overview" data-entity-type="node" data-entity-uuid="28122d3e-dcea-45fc-ae40-2a53130c66d5" data-entity-substitution="canonical">Read More</a></p></div> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item"> <div > <div class="columns remove-top-padding columns--layout-column-wider-left paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="field field--name-field-heading field--type-string field--label-hidden field__item">Our Research</div> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="filtered-list paragraph paragraph--type--kan-filtered-list paragraph--view-mode--default"> <div class="filtered-list__view"> <div class="field field--name-kan-field-views field--type-viewsreference field--label-hidden field__item"><div class="views-element-container"><div class="view view-research view-id-research view-display-id-block_3 js-view-dom-id-a2703e24fa5ed7e005a8077e02b749eb8d28b9f2dfd8a22476cd60c55853f1c9"> <div class="view-header"> <style>.associated-publications {margin-top:15px;} .associated-conditions-procedures {margin-top:15px;} .associated-physicians {margin-top:15px;} .item-research-body a { display: inline-block !important; 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While frequently ...</div></div></div></div> </div> <div class="more-link"><a href="/tsilab-research">View All Research</a></div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item news-for-lab"> <div > <div class="columns text-vert-align--top remove-top-padding columns--layout-column-wider-left paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="field field--name-field-heading field--type-string field--label-hidden field__item">Featured News</div> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="filtered-list paragraph paragraph--type--kan-filtered-list paragraph--view-mode--default"> <div class="filtered-list__view"> <div class="field field--name-kan-field-views field--type-viewsreference field--label-hidden field__item"><div class="views-element-container"><div class="view view-news-events view-id-news_events view-display-id-featured_article_block js-view-dom-id-a1fd02b1fead80336b7aa553afd9f95af992356dc4d284b71c5bbb60b591a376"> <div class="view-content"> <div class="views-row"> <article data-history-node-id="137611" class="node node--type-news node--view-mode-featured"> <div> <div class="corner-detail mobile"> <svg width="50" height="50" viewBox="0 0 50 50" fill="none" xmlns="http://www.w3.org/2000/svg"> <mask id="path-1-inside-1_3369_102218" fill="white"> <path d="M0 0H50V50H0V0Z"/> </mask> <path d="M0 0V-5H-5V0H0ZM0 5H50V-5H0V5ZM5 50V0H-5V50H5Z" fill="#FEB80A" mask="url(#path-1-inside-1_3369_102218)"/> </svg> </div> <div class="corner-detail desktop"> <svg width="100" height="100" viewBox="0 0 100 100" fill="none" xmlns="http://www.w3.org/2000/svg"> <mask id="path-1-inside-1_3369_104160" fill="white"> <path d="M0 0H100V100H0V0Z"/> </mask> <path d="M0 0V-5H-5V0H0ZM0 5H100V-5H0V5ZM5 100V0H-5V100H5Z" fill="#FEB80A" mask="url(#path-1-inside-1_3369_104160)"/> </svg> </div> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__items"> <div class="field__item"> <article class="media media--type-image media--view-mode-news-featured" aria-label="Image about tsilab-the-economist-article"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_featured/public/2024-10/tsilab-the-economist-article.jpg.webp?itok=3Tc0ttFu 1308w" sizes="(min-width: 1290px) 81.75rem, (min-width: 768px) 100vw, (min-width: 560px) 100vw" width="1308" height="935" src="/sites/default/files/styles/news_featured/public/2024-10/tsilab-the-economist-article.jpg.webp?itok=3Tc0ttFu" alt="tsilab-the-economist-article" /> </div> </article> </div> </div> <div class="featured-news-text-wrapper"> <p class="content-title"> <div class="ext__link field field--name-title field--type-string field--label-hidden field__item" target="_blank"><a href="https://www.economist.com/science-and-technology/2024/02/20/new-treatments-are-emerging-for-type-1-diabetes" class="ext__link field field--name-title field--type-string field--label-hidden field__item" target="_blank">The Economist: New treatments are emerging for type-1 diabetes</a></div> </p> <svg class="yellow-arrow" width="6" height="8" viewBox="0 0 6 8" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M6 4L-3.26266e-07 7.4641L-2.34249e-08 0.535898L6 4Z" fill="#FEB80A"/> </svg> <a href="https://www.economist.com/science-and-technology/2024/02/20/new-treatments-are-emerging-for-type-1-diabetes" class="featured-story-link" rel="bookmark">Read full story</a> </div> </div> </article> </div> </div> </div> </div> </div> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="filtered-list paragraph paragraph--type--kan-filtered-list paragraph--view-mode--default"> <div class="filtered-list__view"> <div class="field field--name-kan-field-views field--type-viewsreference field--label-hidden field__item"><div class="views-element-container"><div class="news-with-readmore view view-news-events view-id-news_events view-display-id-block_3 js-view-dom-id-7534f562af1a8b339e59e9f657cba22550a7f0bcf1257c3a6d73a5118b0fccdd"> <div class="view-header"> <style> .news-with-readmore .more-link { margin-top: 18px; 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width: 100%; height: 100%; outline: 0.25rem solid transparent; position: absolute; top: 0; left: 0; border-radius: 30px; } .news-with-readmore .more-link a:hover::before { outline-color: #052049; } .row-with-icon .news-icon { width: 24px !important; display: inline-block; } .row-with-icon.views-row a { display: inline !important; padding-left: 7px; vertical-align: 4px; } </style> </div> <div class="view-content"> <div class="row-with-icon views-row"><img src='/sites/default/files/2024-10/news-icon-2.png' class='news-icon' /><a href="/news/economist-new-treatments-are-emerging-type-1-diabetes" hreflang="en">The Economist: New treatments are emerging for type-1 diabetes</a> </div> <div class="row-with-icon views-row"><img src='/sites/default/files/2024-10/news-icon-2.png' class='news-icon' /><a href="/news/department-surgery-staff-and-faculty-receive-2022-chancellor-awards-diversity" hreflang="en">Department of Surgery staff and faculty receive 2022 Chancellor Awards for Diversity</a> </div> <div class="row-with-icon views-row"><img src='/sites/default/files/2024-10/news-icon-2.png' class='news-icon' /><a href="/news/dr-tobias-deuse-awarded-4-year-nsf-grant-study-effects-aging-aboard-iss-using-novel-platform" hreflang="en">Dr. Tobias Deuse Awarded 4-year NSF Grant to Study Effects of Aging Aboard ISS Using Novel Platform</a> </div> <div class="row-with-icon views-row"><img src='/sites/default/files/2024-10/news-icon-2.png' class='news-icon' /><a href="/news/tobias-deuse-md-and-sonja-schrepfer-md-phd-lead-research-team-unearthing-new-clues-stem-cell" hreflang="en">Tobias Deuse, MD and Sonja Schrepfer, MD, PhD Lead Research Team Unearthing New Clues to Stem Cell Transplant Rejection</a> </div> </div> <div class="more-link"><a href="/news">View All News</a></div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item columns-set-bottom"> <div > <div class="columns text-vert-align--top remove-top-padding columns--layout-column-wider-right paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <figure class="media media--type-image media--view-mode-inline-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2024-08/PXL_20240304_003133858_2-new.jpg.webp?itok=vE9rR0qU 183w, /sites/default/files/styles/max_650x650/public/2024-08/PXL_20240304_003133858_2-new.jpg.webp?itok=yEN6rHNb 366w, /sites/default/files/styles/max_875x875/public/2024-08/PXL_20240304_003133858_2-new.jpg.webp?itok=AqcmXTxV 492w, /sites/default/files/styles/max_1300x1300/public/2024-08/PXL_20240304_003133858_2-new.jpg.webp?itok=z1hzIFNr 732w, /sites/default/files/styles/max_1750x1750/public/2024-08/PXL_20240304_003133858_2-new.jpg.webp?itok=N64jtgP- 985w, /sites/default/files/styles/max_2600x2600/public/2024-08/PXL_20240304_003133858_2-new.jpg.webp?itok=0jSDMKQi 1463w" sizes="(min-width: 76rem) 33rem, calc(100vw - 2.5rem)" width="492" height="875" src="/sites/default/files/styles/max_325x325/public/2024-08/PXL_20240304_003133858_2-new.jpg.webp?itok=vE9rR0qU" alt="TSILab Gallery"> </div> </figure> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__title"> <h2>Featured Publications</h2> </div> <div class="text-block__text"> <ol class="the-pubs"><li style="background-color:white;margin-left:47.0pt;">Hu X, White K, Olroyd AG, DeJesus R, Dominguez A, Dowdle WE, Friera AM, Young A, Wells F, Chu EY, McGill TJ, Lin A, Egenberger K, Gagnon A, Rukstalis JM, Hogrebe NJ, Gattis C, Basco R, Millman JR, Kievit P, Davis MM, Lanier LL, Connolly AJ, Deuse T, <strong>Schrepfer S</strong>. Hypoimmune rhesus macaque induced pluripotent stem cells achieve long-term survival in fully immunocompetent allogeneic recipients. Nat Biotechnol. 2023; doi: 10.1038/s41587-023-01784-x.<o:p></o:p></li><li style="background-color:white;margin-left:47.0pt;">Hu X, Gattis C, Olroyd AG, Friera AM, White K, Young C, Basco R, Lamba M, Wells F, Ankala R, Dowdle WE, Lin A, Egenberger K, Rukstalis JM, Millman JR, Connolly AJ, Deuse T, <strong>Schrepfer S.</strong> Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice. Sci Transl Med. 2023 Apr 12;15(691):eadg5794. doi: 10.1126/scitranslmed.adg5794.</li><li style="background-color:white;margin-left:47.0pt;">Hu X, Manner K, DeJesus R, White K, Gattis C, Ngo P, Bandoro C, Tham E, Chu EY, Young C, Wells F, Basco R, Friera A, Kangeyan D, Beauchesne P, Dowdle WE, Deuse T, Fry TJ, Foster AE, <strong>Schrepfer S.</strong> Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice. Nat Commun. 2023 Apr 10;14(1):2020. doi: 10.1038/s41467-023-37785-2.<o:p></o:p><o:p></o:p><o:p></o:p></li><li style="background-color:white;margin-left:47.0pt;">Gravina A, Tediashvili G, Rajalingam R, Quandt Z, Deisenroth C, <strong>Schrepfer S</strong>, Deuse T. CD64 expression protects cell therapeutics from antibody-mediated rejection. Nat Biotechnol 2023 Jan 2. doi: 10.1038/s41587-022-01540-7.</li><li style="background-color:white;margin-left:47.0pt;">Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi A, Lanier LL, <strong>Schrepfer S.</strong> Hypoimmune iPSC-derived cell products treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice. PNAS 2021;118(28):e2022091118.</li><li style="background-color:white;margin-left:47.0pt;">Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, <strong>Schrepfer S.</strong> The SIRP伪-CD47 immune checkpoint in NK cells. J Exp Med. 2021;218(3):e20200839.<o:p></o:p> <o:p></o:p></li><li style="background-color:white;margin-left:47.0pt;">Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, WO. T, Wahl A, Garcia J, Davis MM, Lanier LL, <strong>Schrepfer S.</strong> Hypo-immunogenic iPSC-derivatives show long-term survival in fully immunocompetent allogeneic recipients. Nat Biotechnol. 2019;37(3):252-258.  doi: 10.1038/s41587-019-0016-3.<o:p></o:p></li></ol> </div> </div> </div></div> </div> </div> </div> </div> </div> </div> <div><style> .paragraph--type--small-cta .field--name-field-title h2 { font-size: 2rem; } .highlite-area { background-color:#fefdee; border:gray 1px solid; padding:14px; } @media (min-width: 64em) { .text-block__title > h2::after { content: ""; width: 100%; display: inline-block; height: 2px; border-bottom: 2px solid #feb80a; margin-left: 1.5rem; margin-right: -100%; } } @media (min-width: 64em) { .text-block__title > h2 { overflow: hidden; width:100% !important; max-width:100% !important; } .node--view-mode-featured .featured-news-text-wrapper { padding: 0 30px 10px 10px !important; max-width: 92% !important; } } .text-block__title > h2 { text-align: left; margin-bottom: 3rem !important; line-height: 1.25; letter-spacing: -0.04rem; } .field__item { margin-top: 0.05rem !important; } .homepage-featured-bio-pic p br {margin-bottom:8px;} .field__item:nth-child(n + 2) h2 { margin-top: 10px; } .less-height { margin-top: 10px !important; margin-bottom: 6px !important; } .column-tippi-pic h3 {margin-bottom:15px;} .featured-news-text-wrapper p { margin: 7px; } .featured-news-text-wrapper { padding: 0 14px 10px !important; max-width: 89% !important; } .item-list.pubs-outerlist { max-height: 660px; } .columns-set-bottom figure.media--type-image.media--view-mode-inline-image { margin-bottom: 1.25rem; max-width: 33rem; width: 70%; margin: auto; } .the-pubs li {margin-bottom:10px;} </style></div> </div> </article> </div> <div id="block-dos-allsitescss" class="block block-block-content block-block-contenta4909052-afa3-4391-af88-9e84f68a8e60"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style> .zoom-1-025:hover { transform: scale(1.025); } .zoom-1-05:hover { transform: scale(1.05); } .zoom-1-1:hover { transform: scale(1.1); } .zoom-1-2:hover { transform: scale(1.2); } .zoom-1-5:hover { transform: scale(1.5); } .zoom, .zoom-1-05, .zoom-1-1, .zoom-1-5, .zoom-1-2, .zoom-1-025 {transition: 1s; z-index:10;} @media (max-width: 54em) { .h1, h1, h1 span.field--name-title { font-size: 2.6rem; letter-spacing: -0.1125rem; } } </style></div> </div> </div> </div> </div> </div> </div> </main> <footer class="footer"> <div class="footer__container"> <div class="footer__wrap"> <div class="footer__inner"> <div class="footer__first"> <figure class="footer__logo"> <a class="footer__logo-link" href="/" title="Home UCSF Department of Surgery"> <picture class="footer__logo-image"> <img class="footer-logo__img" src="/themes/custom/dos/dist/icon/svg/footer-logo.svg" alt="UCSF Footer Logo" width="160" height="79"> </picture> </a> </figure> </div> <div class="footer__second"> <nav role="navigation" aria-labelledby="Footer Menu" id="block-typefooterresearch" class="block block-menu navigation menu--type-footer--research menu--footer"> <h2 class="visually-hidden" id="block-typefooterresearch-menu">Type Footer - 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