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id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Mucin 4</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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Ukrainian" lang="uk" hreflang="uk" data-title="MUC4" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q18029663#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Mucin_4" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" 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href="/w/index.php?title=MUC4&redirect=no" class="mw-redirect" title="MUC4">MUC4</a>)</span></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">MUC4</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/7514">MUC4</a></span>, ASGP, HSA276359, MUC-4, mucin 4, cell surface associated</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/158372">158372</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=MUC4">MUC4</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000278468">MUC4 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (human)"><img alt="Chromosome 3 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/300px-Ideogram_human_chromosome_3.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/450px-Ideogram_human_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/600px-Ideogram_human_chromosome_3.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_3_(human)" class="mw-redirect" title="Chromosome 3 (human)">Chromosome 3 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_3_ideogram.svg" class="mw-file-description" title="Chromosome 3 (human)"><img alt="Chromosome 3 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/300px-Human_chromosome_3_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/450px-Human_chromosome_3_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/600px-Human_chromosome_3_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 285.00091764209px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for MUC4"><img alt="Genomic location for MUC4" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 291px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for MUC4"><img alt="Genomic location for MUC4" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">3q29</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">195,746,765 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">195,811,973 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000278468">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">olfactory zone of nasal mucosa</li><br /><li style="line-height: 137%;">nasal epithelium</li><br /><li style="line-height: 137%;">mucosa of transverse colon</li><br /><li style="line-height: 137%;">palpebral conjunctiva</li><br /><li style="line-height: 137%;">epithelium of nasopharynx</li><br /><li style="line-height: 137%;">bronchial epithelial cell</li><br /><li style="line-height: 137%;">mucosa of sigmoid colon</li><br /><li style="line-height: 137%;">mucosa of pharynx</li><br /><li style="line-height: 137%;">urethra</li><br /><li style="line-height: 137%;">rectum</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px">n/a</ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000278468">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_MUC4_217110_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e5/PBB_GE_MUC4_217110_s_at_fs.png/250px-PBB_GE_MUC4_217110_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e5/PBB_GE_MUC4_217110_s_at_fs.png/375px-PBB_GE_MUC4_217110_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e5/PBB_GE_MUC4_217110_s_at_fs.png/500px-PBB_GE_MUC4_217110_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_MUC4_217109_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/PBB_GE_MUC4_217109_at_fs.png/250px-PBB_GE_MUC4_217109_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/PBB_GE_MUC4_217109_at_fs.png/375px-PBB_GE_MUC4_217109_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/13/PBB_GE_MUC4_217109_at_fs.png/500px-PBB_GE_MUC4_217109_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_MUC4_204895_x_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/PBB_GE_MUC4_204895_x_at_fs.png/250px-PBB_GE_MUC4_204895_x_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/PBB_GE_MUC4_204895_x_at_fs.png/375px-PBB_GE_MUC4_204895_x_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/61/PBB_GE_MUC4_204895_x_at_fs.png/500px-PBB_GE_MUC4_204895_x_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/4585/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030197">extracellular matrix constituent, lubricant activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005176">ErbB-2 class receptor binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005796">Golgi lumen</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031982">vesicle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070062">extracellular exosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">extracellular space</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031012">extracellular matrix</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007160">cell-matrix adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007155">cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030277">maintenance of gastrointestinal epithelium</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016266">O-glycan processing</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002223">stimulatory C-type lectin receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010469">regulation of signaling receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010669">epithelial structure maintenance</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=4585&rn=1">4585</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks">n/a</p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000278468;db=core">ENSG00000278468</a><br /><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000145113;db=core">ENSG00000145113</a><br /><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000273822;db=core">ENSG00000273822</a><br /><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000278303;db=core">ENSG00000278303</a><br /><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000273984;db=core">ENSG00000273984</a><br /></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000276613;db=core">ENSG00000276613</a><br /><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000277585;db=core">ENSG00000277585</a><br /><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000275164;db=core">ENSG00000275164</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks">n/a</p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q99102">Q99102</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks">n/a</p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_138299">NM_138299</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_004532">NM_004532</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_018406">NM_018406</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_138297">NM_138297</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_138298">NM_138298</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001322468">NM_001322468</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks">n/a</span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001309397">NP_001309397</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_004523">NP_004523</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_060876">NP_060876</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_612154">NP_612154</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks">n/a</span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr3:195746765-195811973">Chr 3: 195.75 – 195.81 Mb</a></span></td><td><span class="plainlinks">n/a</span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks">n/a</span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="4" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18029663" class="extiw" title="d:Q18029663">View/Edit Human</a></td><td colspan="0" style="background-color:#eee;text-align:center"></td></tr></tbody></table></td></tr></tbody></table> <p><b>Mucin-4</b> (MUC-4) is a <a href="/wiki/Mucin" title="Mucin">mucin</a> <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>MUC4</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid1673336_3-0" class="reference"><a href="#cite_note-pmid1673336-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Like other mucins, MUC-4 is a high-molecular weight <a href="/wiki/Glycoprotein" title="Glycoprotein">glycoprotein</a>.<sup id="cite_ref-Srivastava_2011_4-0" class="reference"><a href="#cite_note-Srivastava_2011-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>The major constituents of <a href="/wiki/Mucus" title="Mucus">mucus</a>, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane <a href="/wiki/Glycoprotein" title="Glycoprotein">glycoprotein</a> found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues.<sup id="cite_ref-entrez_5-0" class="reference"><a href="#cite_note-entrez-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>MUC-4 has been found to play various roles in the progression of <a href="/wiki/Cancer" title="Cancer">cancer</a>, particularly due to its signaling and anti-adhesive properties which contribute to tumor development and metastasis. It is also found to play roles in other diseases such as <a href="/wiki/Endometriosis" title="Endometriosis">endometriosis</a> and <a href="/wiki/Inflammatory_bowel_disease" title="Inflammatory bowel disease">inflammatory bowel disease</a>. MUC-4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930 <a href="/wiki/Atomic_mass_unit" class="mw-redirect" title="Atomic mass unit">kDa</a> for the actual protein, and up to 4,650 kDa with <a href="/wiki/Glycosylation" title="Glycosylation">glycosylation</a>.<sup id="cite_ref-url_AtlasGeneticsOncology_MUC-4_6-0" class="reference"><a href="#cite_note-url_AtlasGeneticsOncology_MUC-4-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mucin_4&action=edit&section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>MUC4 is an O-glycoprotein that can reach up to 2 <a href="/wiki/Micrometre" title="Micrometre">micrometers</a> outside the cell.<sup id="cite_ref-url_AtlasGeneticsOncology_MUC-4_6-1" class="reference"><a href="#cite_note-url_AtlasGeneticsOncology_MUC-4-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> MUC4 mucin consists of a large extracellular alpha subunit that is heavily glycosylated and a beta subunit that is anchored in the cell membrane and extends into the cytosol.<sup id="cite_ref-Albrecht_2011_7-0" class="reference"><a href="#cite_note-Albrecht_2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> This beta subunit is considered an <a href="/wiki/Oncogene" title="Oncogene">oncogene</a>, whose role in cancer is increasingly being recognized particularly due to its involvement in signalling pathways, particularly with <a href="/wiki/ErbB2" class="mw-redirect" title="ErbB2">ErbB2</a> (Her2).<sup id="cite_ref-Albrecht_2011_7-1" class="reference"><a href="#cite_note-Albrecht_2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> This subunit serves as a ligand for <a href="/wiki/ErbB2" class="mw-redirect" title="ErbB2">ErbB2</a>, which is suggested to cause the repression of apoptosis found in many cancer cells.<sup id="cite_ref-pmid12102554_8-0" class="reference"><a href="#cite_note-pmid12102554-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>The large alpha subunit that is glycosylated likely confers the anti-adhesive properties to the cell, allowing for cell–cell and cell–matrix detachment in normal as well as cancerous cells.<sup id="cite_ref-url_AtlasGeneticsOncology_MUC-4_6-2" class="reference"><a href="#cite_note-url_AtlasGeneticsOncology_MUC-4-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The heavy glycosylation may also serve as a reservoir for growth factors, which may become released upon degradation.<sup id="cite_ref-Chaturvedi_2008_9-0" class="reference"><a href="#cite_note-Chaturvedi_2008-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>The two subunits of MUC4 are transcribed from a single gene<sup id="cite_ref-pmid12102554_8-1" class="reference"><a href="#cite_note-pmid12102554-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> made of 25 exons and with its exon/intron structure identical to that of the mouse gene.<sup id="cite_ref-Desseyn_2002_10-0" class="reference"><a href="#cite_note-Desseyn_2002-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Over 24 splice variants have been found for MUC4 using commercial mRNAs or total RNAs extracted from cancer cell lines.<sup id="cite_ref-url_AtlasGeneticsOncology_MUC-4_6-3" class="reference"><a href="#cite_note-url_AtlasGeneticsOncology_MUC-4-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12153560_11-0" class="reference"><a href="#cite_note-pmid12153560-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Some predicted forms are soluble, while others are membrane bound. However, most of these splice variants are likely artefactual. <sup id="cite_ref-Desseyn_2008_12-0" class="reference"><a href="#cite_note-Desseyn_2008-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Many polymorphisms are observed in the tandem repeat region of the alpha subunit, which has a variable number of repeats.<sup id="cite_ref-pmid1351710_13-0" class="reference"><a href="#cite_note-pmid1351710-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid1219535_14-0" class="reference"><a href="#cite_note-pmid1219535-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mucin_4&action=edit&section=2" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Normal">Normal</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mucin_4&action=edit&section=3" title="Edit section: Normal"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In normal functioning, MUC-4 is known to play anti-adhesive roles in the body, such as in lubricating the reproductive lining.<sup id="cite_ref-pmid21349170_15-0" class="reference"><a href="#cite_note-pmid21349170-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> It is also found in the <a href="/wiki/Respiratory_tract" title="Respiratory tract">respiratory tract</a> - particularly in the <a href="/wiki/Vertebrate_trachea" class="mw-redirect" title="Vertebrate trachea">trachea</a> and <a href="/wiki/Lung" title="Lung">lung</a> - and the <a href="/wiki/Digestive_tract" class="mw-redirect" title="Digestive tract">digestive tract</a> - in the <a href="/wiki/Esophagus" title="Esophagus">esophagus</a> and <a href="/wiki/Colon_(anatomy)" class="mw-redirect" title="Colon (anatomy)">colon</a> - as well as in the visual and auditory systems.<sup id="cite_ref-url_AtlasGeneticsOncology_MUC-4_6-4" class="reference"><a href="#cite_note-url_AtlasGeneticsOncology_MUC-4-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> In these roles, MUC-4 serves to protect and lubricate the epithelium, which facilitates transport and traps foreign particles. One example of its function in the reproductive lining relates to blastocyst implantation resulting from MUC4 downregulation.<sup id="cite_ref-pmid12102554_8-2" class="reference"><a href="#cite_note-pmid12102554-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> It is found to be overexpressed during the luteal phase of <a href="/wiki/Menstruation" title="Menstruation">menstruation</a>.<sup id="cite_ref-pmid7745080_16-0" class="reference"><a href="#cite_note-pmid7745080-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> MUC-4 may also have a role in fetal morphogenic development.<sup id="cite_ref-url_AtlasGeneticsOncology_MUC-4_6-5" class="reference"><a href="#cite_note-url_AtlasGeneticsOncology_MUC-4-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> MUC-4 is not found in the <a href="/wiki/Gallbladder" title="Gallbladder">gallbladder</a>, <a href="/wiki/Pancreas" title="Pancreas">pancreas</a>, or liver except in abnormal conditions such as cancer. MUC-4, however, may normally be found in bodily fluids like saliva, tears, and milk.<sup id="cite_ref-Chaturvedi_2008_9-1" class="reference"><a href="#cite_note-Chaturvedi_2008-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> In the soluble form, MUC-4 appears to lubricate the epithelial mucosa.<sup id="cite_ref-pmid12102554_8-3" class="reference"><a href="#cite_note-pmid12102554-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Disease">Disease</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mucin_4&action=edit&section=4" title="Edit section: Disease"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>MUC-4 is thought to play a role in cancer progression by repressing <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a> and consequently increasing tumor cell proliferation.<sup id="cite_ref-url_GeneCards_MUC-4_17-0" class="reference"><a href="#cite_note-url_GeneCards_MUC-4-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> The molecular mechanism is thought to be through a MUC-4 complex with <a href="/wiki/ERBB2" class="mw-redirect" title="ERBB2">ERBB2</a> receptors, which alters downstream signaling and down regulates <a href="/wiki/CDKN1B" title="CDKN1B">CDKN1B</a>.<sup id="cite_ref-url_GeneCards_MUC-4_17-1" class="reference"><a href="#cite_note-url_GeneCards_MUC-4-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> The beta subunit of MUC-4 appears to serve as a ligand that causes the phosphorylation of <a href="/wiki/ErbB2" class="mw-redirect" title="ErbB2">ErbB2</a>, but does not activate the <a href="/wiki/MAPK" class="mw-redirect" title="MAPK">MAPK</a> or <a href="/wiki/AKT" class="mw-redirect" title="AKT">AKT</a> pathways.<sup id="cite_ref-pmid12386815_18-0" class="reference"><a href="#cite_note-pmid12386815-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> MUC-4 may also affect <a href="/wiki/HER2" title="HER2">HER2</a> signaling, and result in its stabilization.<sup id="cite_ref-url_AtlasGeneticsOncology_MUC-4_6-6" class="reference"><a href="#cite_note-url_AtlasGeneticsOncology_MUC-4-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid18381409_19-0" class="reference"><a href="#cite_note-pmid18381409-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> As a mucin, MUC-4 also alters adhesive properties of the cell. When overexpressed, the disorganization of mucins may reduce adhesion to other cells as well as the <a href="/wiki/Extracellular_matrix" title="Extracellular matrix">extracellular matrix</a>, promoting cancer cell migration and metastasis. </p> <div class="mw-heading mw-heading2"><h2 id="Role_in_cancer">Role in cancer</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mucin_4&action=edit&section=5" title="Edit section: Role in cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Pancreatic">Pancreatic</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mucin_4&action=edit&section=6" title="Edit section: Pancreatic"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>MUC4 is often overexpressed in pancreatic adenocarcinomas and has been shown to promote tumor growth and metastasis, though the mechanism by which it does so is not known.<sup id="cite_ref-Srivastava_2011_4-1" class="reference"><a href="#cite_note-Srivastava_2011-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> MUC4 detection is emerging as a method to diagnose pancreatic cancer, especially since MUC4 is not detectably expressed in normal pancreas and increased expression of MUC-4 suggests a greater progression of the disease.<sup id="cite_ref-Srivastava_2011_4-2" class="reference"><a href="#cite_note-Srivastava_2011-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Scientists have recently experimented with MUC4 inhibition in pancreatic cancer using drug delivery methods such as microRNAs.<sup id="cite_ref-pmid14744777_20-0" class="reference"><a href="#cite_note-pmid14744777-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> Such efforts have been successful at reducing <a href="/wiki/EGF_receptor" class="mw-redirect" title="EGF receptor">EGF receptor</a> expression, its downstream signaling, and consequently malignant behavior of the cancer cell such as migration, invasion, and cell detachment. </p><p><a href="/wiki/Bile_acid" title="Bile acid">Bile acids</a> have been found to stimulate <a href="/wiki/Carcinogenesis" title="Carcinogenesis">carcinogenesis</a> in <a href="/wiki/Pancreatic_cancer" title="Pancreatic cancer">pancreatic ductal adenocarcinoma</a> cells through increased expression of MUC4.<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Esophageal">Esophageal</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mucin_4&action=edit&section=7" title="Edit section: Esophageal"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>MUC4 expression in esophageal cancer often leads to increased tumor proliferation and migration. Like with prostate cancer, increased expression of MUC4 suggests greater development of esophageal cancer. <a href="/wiki/Bile_acids" class="mw-redirect" title="Bile acids">Bile acids</a> present in <a href="/wiki/Gastroesophageal_reflux_disease" title="Gastroesophageal reflux disease">gastroesophageal reflux disease</a> are thought to contribute to this over-expression of MUC4. By inhibiting MUC-4, scientists have been able to reduce cancer cell proliferation, migration, and tumor size as well as reduce protein S100A4 expression, presenting MUC-4 as a good therapeutic target for the treatment of esophageal cancer.<sup id="cite_ref-pmid21889495_22-0" class="reference"><a href="#cite_note-pmid21889495-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Breast">Breast</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mucin_4&action=edit&section=8" title="Edit section: Breast"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Unlike pancreatic and esophageal cancers, MUC4 expression is suppressed in the <a href="/wiki/Primary_tumor" title="Primary tumor">primary tumor</a> when compared to normal cells.<sup id="cite_ref-pmid19761616_23-0" class="reference"><a href="#cite_note-pmid19761616-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> It, however, is found to be overexpressed in lymph node metastases. The initial reduction in MUC-4 appears to promote the transition to the primary tumor, but its subsequent increase in expression facilitate metastasis and ultimately increased malignancy<sup id="cite_ref-pmid19761616_23-1" class="reference"><a href="#cite_note-pmid19761616-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Other">Other</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mucin_4&action=edit&section=9" title="Edit section: Other"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>MUC4 is found to be overexpressed in papillary thyroid carcinoma, and could serve as a potential marker of malignancy and prognosis.<sup id="cite_ref-pmid21615302_24-0" class="reference"><a href="#cite_note-pmid21615302-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> MUC-4 is also found to be a very sensitive and specific marker in <a href="/wiki/Low-grade_fibromyxoid_sarcoma" title="Low-grade fibromyxoid sarcoma">low-grade fibromyxoid sarcoma</a>.<sup id="cite_ref-pmid21415703_25-0" class="reference"><a href="#cite_note-pmid21415703-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Role_in_other_diseases">Role in other diseases</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mucin_4&action=edit&section=10" title="Edit section: Role in other diseases"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>MUC-4 is also relevant to several other disease conditions. Polymorphisms in the MUC4 gene have been found to play a role in the progression of <a href="/wiki/Endometriosis" title="Endometriosis">endometriosis</a> and related infertility,<sup id="cite_ref-pmid21349170_15-1" class="reference"><a href="#cite_note-pmid21349170-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> as well as dysplastic cervical disorders.<sup id="cite_ref-pmid11727258_26-0" class="reference"><a href="#cite_note-pmid11727258-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> MUC-4 also has important roles in <a href="/wiki/Inflammatory_bowel_disease" title="Inflammatory bowel disease">inflammatory bowel disease</a> such as <a href="/wiki/Crohn%27s_disease" title="Crohn's disease">Crohn's disease</a> and is found to be overexpressed in <a href="/wiki/Ulcerative_colitis" title="Ulcerative colitis">ulcerative colitis</a>.<sup id="cite_ref-pmid10908374_27-0" class="reference"><a href="#cite_note-pmid10908374-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Mucin_4&action=edit&section=11" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns 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ENSG00000278303, ENSG00000273984, ENSG00000276613, ENSG00000277585, ENSG00000275164 GRCh38: Ensembl release 89: ENSG00000278468, ENSG00000145113, ENSG00000273822, ENSG00000278303, ENSG00000273984, ENSG00000276613, ENSG00000277585, ENSG00000275164</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output 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title="Glycoconjugate">glycoconjugate</a>: <a href="/wiki/Glycoprotein" title="Glycoprotein">glycoproteins</a> and <a href="/wiki/Glycopeptide" title="Glycopeptide">glycopeptides</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Mucoprotein" title="Mucoprotein">Mucoproteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Mucin" title="Mucin">Mucin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/CD164" title="CD164">CD164</a></li> <li><a href="/wiki/MUC1" class="mw-redirect" title="MUC1">MUC1</a></li> <li><a href="/wiki/MUC2" class="mw-redirect" title="MUC2">MUC2</a></li> <li><a href="/wiki/MUC3A" class="mw-redirect" title="MUC3A">MUC3A</a></li> <li><a href="/wiki/MUC3B" class="mw-redirect" title="MUC3B">MUC3B</a></li> <li><a href="/wiki/MUC4" class="mw-redirect" title="MUC4">MUC4</a></li> <li><a href="/wiki/MUC5AC" class="mw-redirect" title="MUC5AC">MUC5AC</a></li> <li><a href="/wiki/MUC5B" class="mw-redirect" title="MUC5B">MUC5B</a></li> <li><a href="/wiki/MUC6" class="mw-redirect" title="MUC6">MUC6</a></li> <li><a href="/wiki/MUC7" class="mw-redirect" title="MUC7">MUC7</a></li> <li><a href="/wiki/MUC8" class="mw-redirect" title="MUC8">MUC8</a></li> <li><a href="/wiki/Mucin" title="Mucin">MUC12</a></li> <li><a href="/wiki/MUC13" class="mw-redirect" title="MUC13">MUC13</a></li> <li><a href="/wiki/MUC15" class="mw-redirect" title="MUC15">MUC15</a></li> <li><a href="/wiki/CA-125" class="mw-redirect" title="CA-125">MUC16</a></li> <li><a href="/wiki/MUC17" class="mw-redirect" title="MUC17">MUC17</a></li> <li><a href="/wiki/MUC19" class="mw-redirect" title="MUC19">MUC19</a></li> <li><a href="/wiki/MUC20" class="mw-redirect" title="MUC20">MUC20</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Haptoglobin" title="Haptoglobin">Haptoglobin</a></li> <li><a href="/wiki/Intrinsic_factor" title="Intrinsic factor">Intrinsic factor</a></li> <li><a href="/wiki/Orosomucoid" title="Orosomucoid">Orosomucoid</a></li> <li><a href="/wiki/Peptidoglycan" title="Peptidoglycan">Peptidoglycan</a></li> <li><a href="/wiki/Phytohaemagglutinin" title="Phytohaemagglutinin">Phytohaemagglutinin</a></li> <li><a href="/wiki/Ovomucin" title="Ovomucin">Ovomucin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Proteoglycan" title="Proteoglycan">Proteoglycans</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a>/<a href="/wiki/Dermatan_sulfate" title="Dermatan sulfate">DS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Decorin" title="Decorin">Decorin</a></li> <li><a href="/wiki/Biglycan" title="Biglycan">Biglycan</a></li> <li><a href="/wiki/Versican" title="Versican">Versican</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Heparan_sulfate" title="Heparan sulfate">HS</a>/<a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Testican" title="Testican">Testican</a></li> <li><a href="/wiki/Perlecan" title="Perlecan">Perlecan</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chondroitin_sulfate_proteoglycan" title="Chondroitin sulfate proteoglycan">Chondroitin sulfate proteoglycans</a>: <a href="/wiki/Aggrecan" title="Aggrecan">Aggrecan</a></li> <li><a href="/wiki/Neurocan" title="Neurocan">Neurocan</a></li> <li><a href="/wiki/Brevican" title="Brevican">Brevican</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/CSPG4" title="CSPG4">CSPG4</a></li> <li><a href="/wiki/CSPG5" title="CSPG5">CSPG5</a></li> <li><a href="/wiki/Platelet_factor_4" title="Platelet factor 4">Platelet factor 4</a></li> <li><a href="/wiki/SMC3_(gene)" class="mw-redirect" title="SMC3 (gene)">Structural maintenance of chromosomes 3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Keratan_sulfate" title="Keratan sulfate">KS</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fibromodulin" title="Fibromodulin">Fibromodulin</a></li> <li><a href="/wiki/Lumican" title="Lumican">Lumican</a></li> <li><a href="/wiki/Keratocan" title="Keratocan">Keratocan</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Heparan_sulfate" title="Heparan sulfate">HS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Syndecan_1" title="Syndecan 1">Syndecan 1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activin_and_inhibin" title="Activin and inhibin">Activin and inhibin</a></li> <li><a href="/wiki/A_disintegrin_and_metalloproteinase" class="mw-redirect" title="A disintegrin and metalloproteinase">ADAM</a></li> <li><a href="/wiki/Alpha_1-antichymotrypsin" title="Alpha 1-antichymotrypsin">Alpha 1-antichymotrypsin</a></li> <li><a href="/wiki/Apolipoprotein_H" title="Apolipoprotein H">Apolipoprotein H</a></li> <li><a href="/wiki/CD70" title="CD70">CD70</a></li> <li><a href="/wiki/Asialoglycoprotein" title="Asialoglycoprotein">Asialoglycoprotein</a></li> <li><a href="/wiki/Avidin" title="Avidin">Avidin</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">B-cell activating factor</a></li> <li><a href="/wiki/4-1BB_ligand" class="mw-redirect" title="4-1BB ligand">4-1BB ligand</a></li> <li><a href="/wiki/Cholesterylester_transfer_protein" class="mw-redirect" title="Cholesterylester transfer protein">Cholesterylester transfer protein</a></li> <li><a href="/wiki/Clusterin" title="Clusterin">Clusterin</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factor</a></li> <li><a href="/wiki/Hemopexin" title="Hemopexin">Hemopexin</a></li> <li><a href="/wiki/Lactoferrin" title="Lactoferrin">Lactoferrin</a></li> <li><a href="/wiki/Membrane_glycoproteins" title="Membrane glycoproteins">Membrane glycoproteins</a></li> <li><a href="/wiki/Myelin_protein_zero" title="Myelin protein zero">Myelin protein zero</a></li> <li><a href="/wiki/Osteonectin" title="Osteonectin">Osteonectin</a></li> <li><a href="/wiki/Protein_C" title="Protein C">Protein C</a></li> <li><a href="/wiki/Protein_S" title="Protein S">Protein S</a></li> <li><a href="/wiki/Serum_amyloid_P_component" title="Serum amyloid P component">Serum amyloid P component</a></li> <li><a href="/wiki/Sialoglycoprotein" title="Sialoglycoprotein">Sialoglycoprotein</a> <ul><li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/Glycophorin" title="Glycophorin">Glycophorin</a></li> <li><a href="/wiki/Glycophorin_C" title="Glycophorin C">Glycophorin C</a></li></ul></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin</a></li> <li><a href="/wiki/Thyroglobulin" title="Thyroglobulin">Thyroglobulin</a></li> <li><a href="/wiki/Thyroxine-binding_proteins" title="Thyroxine-binding proteins">Thyroxine-binding proteins</a></li> <li><a href="/wiki/Transcortin" title="Transcortin">Transcortin</a></li> <li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">Tumor necrosis factor alpha</a></li> <li><a href="/wiki/Uteroglobin" title="Uteroglobin">Uteroglobin</a></li> <li><a href="/wiki/Vitronectin" title="Vitronectin">Vitronectin</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Mucin_4&oldid=1215908667">https://en.wikipedia.org/w/index.php?title=Mucin_4&oldid=1215908667</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" 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