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Available in 5 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-5" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">5 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/MPZ" title="MPZ – Bosnian" lang="bs" hreflang="bs" data-title="MPZ" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/MPZ" title="MPZ – Welsh" lang="cy" hreflang="cy" data-title="MPZ" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Myelinprotein_null" title="Myelinprotein null – Norwegian Nynorsk" lang="nn" hreflang="nn" data-title="Myelinprotein null" data-language-autonym="Norsk nynorsk" data-language-local-name="Norwegian Nynorsk" class="interlanguage-link-target"><span>Norsk nynorsk</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/MPZ" title="MPZ – Tatar" lang="tt" hreflang="tt" data-title="MPZ" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/MPZ" title="MPZ – Ukrainian" lang="uk" hreflang="uk" data-title="MPZ" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q14912888#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Myelin_protein_zero" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon 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vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">MPZ</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_MPZ_PDB_1neu.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Protein_MPZ_PDB_1neu.png/250px-Protein_MPZ_PDB_1neu.png" decoding="async" width="250" height="157" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Protein_MPZ_PDB_1neu.png/375px-Protein_MPZ_PDB_1neu.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/Protein_MPZ_PDB_1neu.png/500px-Protein_MPZ_PDB_1neu.png 2x" data-file-width="983" data-file-height="617" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P27573%20or%20P25189">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P27573,P25189">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3OAI">3OAI</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/7225">MPZ</a></span>, CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, P0, myelin protein zero, CHN2</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/159440">159440</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:103177">103177</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=445">445</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=MPZ">MPZ</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000158887">MPZ - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_1.svg" class="mw-file-description" title="Chromosome 1 (human)"><img alt="Chromosome 1 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/450px-Ideogram_human_chromosome_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/600px-Ideogram_human_chromosome_1.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_1_(human)" class="mw-redirect" title="Chromosome 1 (human)">Chromosome 1 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_1_ideogram.svg" class="mw-file-description" title="Chromosome 1 (human)"><img alt="Chromosome 1 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/300px-Human_chromosome_1_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/450px-Human_chromosome_1_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/600px-Human_chromosome_1_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 185.17892581787px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for MPZ"><img alt="Genomic location for MPZ" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 191.2px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for MPZ"><img alt="Genomic location for MPZ" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">1q23.3</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">161,304,735 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">161,309,968 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_1.svg" class="mw-file-description" title="Chromosome 1 (mouse)"><img alt="Chromosome 1 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/260px-Ideogram_house_mouse_chromosome_1.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/390px-Ideogram_house_mouse_chromosome_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/520px-Ideogram_house_mouse_chromosome_1.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 1 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_1.svg" class="mw-file-description" title="Chromosome 1 (mouse)"><img alt="Chromosome 1 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Ideogram_of_house_mouse_chromosome_1.svg/300px-Ideogram_of_house_mouse_chromosome_1.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Ideogram_of_house_mouse_chromosome_1.svg/450px-Ideogram_of_house_mouse_chromosome_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Ideogram_of_house_mouse_chromosome_1.svg/600px-Ideogram_of_house_mouse_chromosome_1.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 251.88456441359px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for MPZ"><img alt="Genomic location for MPZ" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 257.9px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for MPZ"><img alt="Genomic location for MPZ" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">1 H3|1 79.05 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">170,978,280 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">170,988,699 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000158887">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">tibial nerve</li><br /><li style="line-height: 137%;">sural nerve</li><br /><li style="line-height: 137%;">olfactory bulb</li><br /><li style="line-height: 137%;">trigeminal ganglion</li><br /><li style="line-height: 137%;">spinal ganglia</li><br /><li style="line-height: 137%;">muscle layer of sigmoid colon</li><br /><li style="line-height: 137%;">left coronary artery</li><br /><li style="line-height: 137%;">right auricle</li><br /><li style="line-height: 137%;">testicle</li><br /><li style="line-height: 137%;">seminal vesicula</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000056569">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">somatic nerve plexus</li><br /><li style="line-height: 137%;">lumbosacral plexus</li><br /><li style="line-height: 137%;">sciatic nerve</li><br /><li style="line-height: 137%;">utricle</li><br /><li style="line-height: 137%;">ankle</li><br /><li style="line-height: 137%;">lip</li><br /><li style="line-height: 137%;">brachial plexus</li><br /><li style="line-height: 137%;">vestibular sensory epithelium</li><br /><li style="line-height: 137%;">esophagus</li><br /><li style="line-height: 137%;">external carotid artery</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000158887">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_MPZ_210280_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b2/PBB_GE_MPZ_210280_at_fs.png/250px-PBB_GE_MPZ_210280_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b2/PBB_GE_MPZ_210280_at_fs.png/375px-PBB_GE_MPZ_210280_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b2/PBB_GE_MPZ_210280_at_fs.png/500px-PBB_GE_MPZ_210280_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/4359/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005198">structural molecule activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043209">myelin sheath</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005791">rough endoplasmic reticulum</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005764">lysosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016323">basolateral plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043066">negative regulation of apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007268">chemical synaptic transmission</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042552">myelination</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098742">cell-cell adhesion via plasma-membrane adhesion molecules</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098743">cell aggregation</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=4359&rn=1">4359</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=17528&rn=1">17528</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000158887;db=core">ENSG00000158887</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000056569;db=core">ENSMUSG00000056569</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P25189">P25189</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P27573">P27573</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000530">NM_000530</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001315491">NM_001315491</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_008623">NM_008623</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001315499">NM_001315499</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001315500">NM_001315500</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000521">NP_000521</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001302420">NP_001302420</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001302428">NP_001302428</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001302429">NP_001302429</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_032649">NP_032649</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr1:161304735-161309968">Chr 1: 161.3 – 161.31 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr1:170978280-170988699">Chr 1: 170.98 – 170.99 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14912888" class="extiw" title="d:Q14912888">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14912889" class="extiw" title="d:Q14912889">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Myelin protein zero</b> (<b>P0</b>, <b>MPZ</b>) is a single membrane <a href="/wiki/Glycoprotein" title="Glycoprotein">glycoprotein</a><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> which in humans is encoded by the <i>MPZ</i> gene. P0 is a major structural component of the <a href="/wiki/Myelin_sheath" class="mw-redirect" title="Myelin sheath">myelin sheath</a> in the <a href="/wiki/Peripheral_nervous_system" title="Peripheral nervous system">peripheral nervous system (PNS)</a>.<sup id="cite_ref-Shy_2006_6-0" class="reference"><a href="#cite_note-Shy_2006-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Myelin protein zero is expressed by <a href="/wiki/Schwann_cell" title="Schwann cell">Schwann cells</a> and accounts for over 50% of all proteins in the peripheral nervous system, making it the most common protein expressed in the PNS.<sup id="cite_ref-Shy_2006_6-1" class="reference"><a href="#cite_note-Shy_2006-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Mutations in myelin protein zero can cause myelin deficiency and are associated with <a href="/wiki/Peripheral_neuropathy" title="Peripheral neuropathy">neuropathies</a> like <a href="/wiki/Charcot%E2%80%93Marie%E2%80%93Tooth_disease" title="Charcot–Marie–Tooth disease">Charcot–Marie–Tooth disease</a> and <a href="/wiki/Dejerine%E2%80%93Sottas_disease" title="Dejerine–Sottas disease">Dejerine–Sottas disease</a>.<sup id="cite_ref-Shy_2004_7-0" class="reference"><a href="#cite_note-Shy_2004-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Myelin_protein_zero&action=edit&section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="float:left; clear:left; margin: 0.5em 1em 0.5em 0;"><tbody><tr><th colspan="2" class="infobox-above">Myelin-PO_C</th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Structure_of_Extracellular_domain_of_Myelin_Protein_Zero_with_Labelled_BetaSheets_.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ab/Structure_of_Extracellular_domain_of_Myelin_Protein_Zero_with_Labelled_BetaSheets_.png/220px-Structure_of_Extracellular_domain_of_Myelin_Protein_Zero_with_Labelled_BetaSheets_.png" decoding="async" width="220" height="301" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ab/Structure_of_Extracellular_domain_of_Myelin_Protein_Zero_with_Labelled_BetaSheets_.png/330px-Structure_of_Extracellular_domain_of_Myelin_Protein_Zero_with_Labelled_BetaSheets_.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ab/Structure_of_Extracellular_domain_of_Myelin_Protein_Zero_with_Labelled_BetaSheets_.png/440px-Structure_of_Extracellular_domain_of_Myelin_Protein_Zero_with_Labelled_BetaSheets_.png 2x" data-file-width="869" data-file-height="1188" /></a></span><div class="infobox-caption">Structure of myelin protein zero's extracellular domain with labelled beta strands. Strands D, E, B, and A make up one beta sheet, Strands A', G, F, C, C', C'' make up the other beta sheet.</div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">Myelin-PO_C</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a></th><td class="infobox-data pfam" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF10570">PF10570</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/InterPro" title="InterPro">InterPro</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR019566">IPR019566</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Orientations_of_Proteins_in_Membranes_database" title="Orientations of Proteins in Membranes database">OPM superfamily</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://opm.phar.umich.edu/protein_superfamilies/193">193</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Orientations_of_Proteins_in_Membranes_database" title="Orientations of Proteins in Membranes database">OPM protein</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://opm.phar.umich.edu/proteins?search=3oai">3oai</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Membranome_database" title="Membranome database">Membranome</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://membranome.org/protein_families/213">213</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Available protein structures:</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Pfam" title="Pfam">Pfam</a>  </th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="http://pfam.xfam.org/family/PF10570?tab=pdbBlock">structures</a> / <a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/search?kw=PF10570">ECOD</a>  </td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_annotation.annotation_id:PF10570%20AND%20rcsb_polymer_entity_annotation.type:Pfam">RCSB PDB</a>; <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?pfam_accession:PF10570">PDBe</a>; <a rel="nofollow" class="external text" href="https://pdbj.org/search/pdb?other_db_select=PFam&other_db_field=PF10570">PDBj</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PDBsum" title="PDBsum">PDBsum</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF10570">structure summary</a></td></tr></tbody></table></td></tr></tbody></table> <p>In humans, the gene that encodes myelin protein zero is located on <a href="/wiki/Chromosome_1" title="Chromosome 1">chromosome 1</a> near the <a href="/wiki/Duffy_antigen_system" title="Duffy antigen system">Duffy locus</a> or the Duffy antigen/chemokine receptor. The gene is about 7,000 bases long and is divided into 6 exons. In total, myelin protein zero is 219 amino acids long<sup id="cite_ref-Shy_2006_6-2" class="reference"><a href="#cite_note-Shy_2006-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> and has many basic amino acid residues.<sup id="cite_ref-Shapiro_1996_8-0" class="reference"><a href="#cite_note-Shapiro_1996-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>Myelin protein zero consists of an <a href="/wiki/Extracellular" class="mw-redirect" title="Extracellular">extracellular</a> N-terminal domain (amino acids 1–124), a single <a href="/wiki/Protein_kinase#Receptor_tyrosine_kinases" title="Protein kinase">transmembrane</a> region (125–150), and a smaller positively charged <a href="/wiki/Intracellular" class="mw-redirect" title="Intracellular">intracellular</a> region (151–219).<sup id="cite_ref-Shy_2006_6-3" class="reference"><a href="#cite_note-Shy_2006-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid2578885_9-0" class="reference"><a href="#cite_note-pmid2578885-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_10-0" class="reference"><a href="#cite_note-:4-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Its cytoplasmic domain is highly positively charged but presumably does not fold into a globular structure.<sup id="cite_ref-Jan_2013_11-0" class="reference"><a href="#cite_note-Jan_2013-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> The extracellular domain is structurally similar to the <a href="/wiki/Immunoglobin" class="mw-redirect" title="Immunoglobin">immunoglobulin</a> domain<sup id="cite_ref-Shapiro_1996_8-1" class="reference"><a href="#cite_note-Shapiro_1996-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> and therefore the protein is considered as belonging to <a href="/wiki/Immunoglobulin_superfamily" title="Immunoglobulin superfamily">immunoglobulin superfamily</a>.<sup id="cite_ref-Kamholz_2007_12-0" class="reference"><a href="#cite_note-Kamholz_2007-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p><p> Besides existing as a monomer, myelin protein zero is also known to form dimers and tetramers with other myelin protein zero molecules in vertebrates.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></p><div style="clear:left;" class=""></div> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Myelin_protein_zero&action=edit&section=2" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <a href="/wiki/Myelin_sheath" class="mw-redirect" title="Myelin sheath">myelin sheath</a> is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction. Myelin protein zero, absent in the central nervous system,<sup id="cite_ref-pmid2435734_14-0" class="reference"><a href="#cite_note-pmid2435734-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> is a major component of the <a href="/wiki/Myelin" title="Myelin">myelin</a> sheath in <a href="/wiki/Peripheral_nervous_system" title="Peripheral nervous system">peripheral</a> <a href="/wiki/Nerve" title="Nerve">nerves</a>. Mutations that disrupt the function of myelin protein zero can lead to less expression of myelin and degeneration of myelin sheath in the peripheral nervous system.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Currently, myelin protein zero expression is postulated to be produced by signals from the axon. However, more details about the regulation of myelin protein zero are unknown.<sup id="cite_ref-Shy_2006_6-4" class="reference"><a href="#cite_note-Shy_2006-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>It is postulated that myelin protein zero is a <a href="/wiki/Cis-regulatory_element" title="Cis-regulatory element">structural element</a> in the formation and stabilization of peripheral nerve myelin.<sup id="cite_ref-pmid2578885_9-1" class="reference"><a href="#cite_note-pmid2578885-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Myelin protein zero is also hypothesized to serve as a cell adhesion molecule, holding multiple layers of myelin together.<sup id="cite_ref-:4_10-1" class="reference"><a href="#cite_note-:4-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> When a myelinating cell wraps its membrane around an axon multiple times, generating multiple layers of myelin, myelin protein zero helps keep these sheets compact by serving as a "glue" that keeps the layers of myelin together.<sup id="cite_ref-Jan_2013_11-1" class="reference"><a href="#cite_note-Jan_2013-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> It does so by holding its characteristic coil <a href="/wiki/Secondary_structure" class="mw-redirect" title="Secondary structure">structure</a> together by the electrostatic interactions<sup id="cite_ref-Shapiro_1996_8-2" class="reference"><a href="#cite_note-Shapiro_1996-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> of its positively charged intracellular domain with <a href="/wiki/Acidic" class="mw-redirect" title="Acidic">acidic</a> <a href="/wiki/Lipids" class="mw-redirect" title="Lipids">lipids</a> in the <a href="/wiki/Cytoplasm" title="Cytoplasm">cytoplasmic</a> face of the opposite bilayer.<sup id="cite_ref-pmid2435734_14-1" class="reference"><a href="#cite_note-pmid2435734-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> and by interaction between <a href="/wiki/Hydrophobic" class="mw-redirect" title="Hydrophobic">hydrophobic</a> globular 'heads' of adjacent extracellular <a href="/wiki/Protein_domain" title="Protein domain">domains</a>.<sup id="cite_ref-pmid2435734_14-2" class="reference"><a href="#cite_note-pmid2435734-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p><p>Myelin protein zero's function is similar to the function of other proteins with immunoglobin domains like polyimmunoglobin and T4 protein. These proteins function as binding and adhesion molecules and participate in homotypic interactions, or interactions that involve two similar proteins.<sup id="cite_ref-pmid2578885_9-2" class="reference"><a href="#cite_note-pmid2578885-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Myelin protein zero holds together the myelin sheath by participating in homotypic interactions with other myelin protein zero proteins. Myelin protein zero's extracellular domain binds to the myelin <a href="/wiki/Sphingolipid" title="Sphingolipid">sphingolipid</a> membrane and holds together myelin layers using homotypic interactions with other myelin protein zero extracellular domains,<sup id="cite_ref-Shy_2004_7-1" class="reference"><a href="#cite_note-Shy_2004-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> and with extracellular tryptophan residues interacting with the membrane.<sup id="cite_ref-Shapiro_1996_8-3" class="reference"><a href="#cite_note-Shapiro_1996-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>Myelin protein zero has also been demonstrated to <a href="/wiki/Protein%E2%80%93protein_interaction" title="Protein–protein interaction">interact</a> with other proteins like <a href="/wiki/Peripheral_myelin_protein_22" title="Peripheral myelin protein 22">peripheral myelin protein 22</a>.<sup id="cite_ref-pmid10212299_16-0" class="reference"><a href="#cite_note-pmid10212299-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> However, at this point the purpose of these interactions has not yet been determined.<sup id="cite_ref-pmid10212299_16-1" class="reference"><a href="#cite_note-pmid10212299-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Associations_with_neuropathy">Associations with neuropathy</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Myelin_protein_zero&action=edit&section=3" title="Edit section: Associations with neuropathy"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Mutations in myelin protein zero are known to cause myelin degeneration and <a href="/wiki/Peripheral_neuropathy" title="Peripheral neuropathy">neuropathy</a>.<sup id="cite_ref-Shy_2004_7-2" class="reference"><a href="#cite_note-Shy_2004-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Mutations that reduce myelin protein zero's adhesion function or its ability to participate in homeotypic interactions with other myelin protein zero proteins are thought to cause neuropathy.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> Mutations to myelin protein zero can lead to issues with the development of myelin early on in life or myelin degeneration on the axon later on in life.<sup id="cite_ref-Kamholz_2007_12-1" class="reference"><a href="#cite_note-Kamholz_2007-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Some mutations can cause neuropathy in infancy like <a href="/wiki/Dejerine%E2%80%93Sottas_disease" title="Dejerine–Sottas disease">Derjerine-Sottas disease</a> while other mutations can cause neuropathy within the first two decades of life like <a href="/wiki/Charcot%E2%80%93Marie%E2%80%93Tooth_disease" title="Charcot–Marie–Tooth disease">Charcot-Marie-Tooth disease</a>.<sup id="cite_ref-Shy_2004_7-3" class="reference"><a href="#cite_note-Shy_2004-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Adding a charged amino acid or changing a cysteine residue in the extracellular membrane can lead to neuropathy onset early on. Truncating the cytoplasmic domain or changing the tertiary structure of myelin protein zero can also result in neuropathy<sup id="cite_ref-Shy_2004_7-4" class="reference"><a href="#cite_note-Shy_2004-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> because the cytoplasmic domain has been demonstrated to be necessary for homotypic interactions.<sup id="cite_ref-Kamholz_2007_12-2" class="reference"><a href="#cite_note-Kamholz_2007-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Myelin_protein_zero&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Structure&rft.atitle=Membrane+adhesion+in+peripheral+myelin%3A+good+and+bad+wraps+with+protein+P0&rft.volume=4&rft.issue=11&rft.pages=1239-44&rft.date=1996-11&rft_id=info%3Adoi%2F10.1016%2Fs0969-2126%2896%2900132-3&rft_id=info%3Apmid%2F8939762&rft.aulast=Kirschner&rft.aufirst=DA&rft.au=Inouye%2C+H&rft.au=Saavedra%2C+RA&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fs0969-2126%252896%252900132-3&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMyelin+protein+zero" class="Z3988"></span></span> </li> <li id="cite_note-pmid10212299-16"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid10212299_16-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid10212299_16-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFD'UrsoEhrhardtMüller1999" class="citation journal cs1">D'Urso D, Ehrhardt P, Müller HW (May 1999). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782240">"Peripheral myelin protein 22 and protein zero: a novel association in peripheral nervous system myelin"</a>. <i>The Journal of Neuroscience</i>. <b>19</b> (9): 3396–403. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.19-09-03396.1999">10.1523/JNEUROSCI.19-09-03396.1999</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782240">6782240</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10212299">10212299</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=Peripheral+myelin+protein+22+and+protein+zero%3A+a+novel+association+in+peripheral+nervous+system+myelin&rft.volume=19&rft.issue=9&rft.pages=3396-403&rft.date=1999-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6782240%23id-name%3DPMC&rft_id=info%3Apmid%2F10212299&rft_id=info%3Adoi%2F10.1523%2FJNEUROSCI.19-09-03396.1999&rft.aulast=D%27Urso&rft.aufirst=D&rft.au=Ehrhardt%2C+P&rft.au=M%C3%BCller%2C+HW&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6782240&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMyelin+protein+zero" class="Z3988"></span></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPareysonMarchesiSalsano2013" class="citation cs2">Pareyson D, Marchesi C, Salsano E (2013), "Dominant Charcot–Marie–Tooth syndrome and cognate disorders", <i>Peripheral Nerve Disorders</i>, Handbook of Clinical Neurology, vol. 115, Elsevier, pp. 817–845, <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fb978-0-444-52902-2.00047-3">10.1016/b978-0-444-52902-2.00047-3</a>, <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780444529022" title="Special:BookSources/9780444529022"><bdi>9780444529022</bdi></a>, <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23931817">23931817</a></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Dominant+Charcot%E2%80%93Marie%E2%80%93Tooth+syndrome+and+cognate+disorders&rft.btitle=Peripheral+Nerve+Disorders&rft.series=Handbook+of+Clinical+Neurology&rft.pages=817-845&rft.pub=Elsevier&rft.date=2013&rft_id=info%3Apmid%2F23931817&rft_id=info%3Adoi%2F10.1016%2Fb978-0-444-52902-2.00047-3&rft.isbn=9780444529022&rft.aulast=Pareyson&rft.aufirst=Davide&rft.au=Marchesi%2C+Chiara&rft.au=Salsano%2C+Ettore&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMyelin+protein+zero" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Myelin_protein_zero&action=edit&section=5" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPatelLupski1994" class="citation journal cs1">Patel PI, Lupski JR (April 1994). 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Human+Mutation&rft.atitle=Mutations+in+the+myelin+protein+zero+gene+associated+with+Charcot-Marie-Tooth+disease+type+1B&rft.volume=6&rft.issue=1&rft.pages=50-4&rft.date=1995&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A20852048%23id-name%3DS2CID&rft_id=info%3Apmid%2F7550231&rft_id=info%3Adoi%2F10.1002%2Fhumu.1380060110&rft.aulast=Latour&rft.aufirst=P&rft.au=Blanquet%2C+F&rft.au=Nelis%2C+E&rft.au=Bonnebouche%2C+C&rft.au=Chapon%2C+F&rft.au=Diraison%2C+P&rft.au=Ollagnon%2C+E&rft.au=Dautigny%2C+A&rft.au=Pham-Dinh%2C+D&rft.au=Chazot%2C+G&rft_id=https%3A%2F%2Fdoi.org%2F10.1002%252Fhumu.1380060110&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMyelin+protein+zero" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a 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.side-box-left{margin-right:1em}}</style><style data-mw-deduplicate="TemplateStyles:r1237033735">@media print{body.ns-0 .mw-parser-output .sistersitebox{display:none!important}}@media screen{html.skin-theme-clientpref-night .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}</style><div class="side-box side-box-right plainlinks sistersitebox"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style> <div class="side-box-flex"> <div class="side-box-image"><span class="noviewer" typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Wiktionary-logo-en-v2.svg/40px-Wiktionary-logo-en-v2.svg.png" decoding="async" width="40" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Wiktionary-logo-en-v2.svg/60px-Wiktionary-logo-en-v2.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/99/Wiktionary-logo-en-v2.svg/80px-Wiktionary-logo-en-v2.svg.png 2x" data-file-width="512" data-file-height="512" /></span></span></div> <div class="side-box-text plainlist">Look up <i><b><a href="https://en.wiktionary.org/wiki/myelin_protein_zero" class="extiw" title="wiktionary:myelin protein zero">myelin protein zero</a></b></i> in Wiktionary, the free dictionary.</div></div> </div> <ul><li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=cmt1">GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 1</a></li> <li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/books/NBK1285/">GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2</a></li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Myelin+protein+zero">Myelin+protein+zero</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P25189">P25189</a></i> (Myelin protein P0) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist 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class="mw-file-description" title="1neu: STRUCTURE OF MYELIN MEMBRANE ADHESION MOLECULE P0"><img alt="1neu: STRUCTURE OF MYELIN MEMBRANE ADHESION MOLECULE P0" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1c/PDB_1neu_EBI.jpg/180px-PDB_1neu_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1c/PDB_1neu_EBI.jpg/270px-PDB_1neu_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1c/PDB_1neu_EBI.jpg/360px-PDB_1neu_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1neu</b>: STRUCTURE OF MYELIN MEMBRANE ADHESION MOLECULE P0</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Protein,_glycoconjugate:_glycoproteins_and_glycopeptides" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Glycoproteins" title="Template:Glycoproteins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Glycoproteins" title="Template talk:Glycoproteins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Glycoproteins" title="Special:EditPage/Template:Glycoproteins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Protein,_glycoconjugate:_glycoproteins_and_glycopeptides" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Protein</a>, <a href="/wiki/Glycoconjugate" title="Glycoconjugate">glycoconjugate</a>: <a href="/wiki/Glycoprotein" title="Glycoprotein">glycoproteins</a> and <a href="/wiki/Glycopeptide" title="Glycopeptide">glycopeptides</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Mucoprotein" title="Mucoprotein">Mucoproteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Mucin" title="Mucin">Mucin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/CD164" title="CD164">CD164</a></li> <li><a href="/wiki/MUC1" class="mw-redirect" title="MUC1">MUC1</a></li> <li><a href="/wiki/MUC2" class="mw-redirect" title="MUC2">MUC2</a></li> <li><a href="/wiki/MUC3A" class="mw-redirect" title="MUC3A">MUC3A</a></li> <li><a href="/wiki/MUC3B" class="mw-redirect" title="MUC3B">MUC3B</a></li> <li><a href="/wiki/MUC4" class="mw-redirect" title="MUC4">MUC4</a></li> <li><a href="/wiki/MUC5AC" class="mw-redirect" title="MUC5AC">MUC5AC</a></li> <li><a href="/wiki/MUC5B" class="mw-redirect" title="MUC5B">MUC5B</a></li> <li><a href="/wiki/MUC6" class="mw-redirect" title="MUC6">MUC6</a></li> <li><a href="/wiki/MUC7" class="mw-redirect" title="MUC7">MUC7</a></li> <li><a href="/wiki/MUC8" class="mw-redirect" title="MUC8">MUC8</a></li> <li><a href="/wiki/Mucin" title="Mucin">MUC12</a></li> <li><a href="/wiki/MUC13" class="mw-redirect" title="MUC13">MUC13</a></li> <li><a href="/wiki/MUC15" class="mw-redirect" title="MUC15">MUC15</a></li> <li><a href="/wiki/CA-125" class="mw-redirect" title="CA-125">MUC16</a></li> <li><a href="/wiki/MUC17" class="mw-redirect" title="MUC17">MUC17</a></li> <li><a href="/wiki/MUC19" class="mw-redirect" title="MUC19">MUC19</a></li> <li><a href="/wiki/MUC20" class="mw-redirect" title="MUC20">MUC20</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Haptoglobin" title="Haptoglobin">Haptoglobin</a></li> <li><a href="/wiki/Intrinsic_factor" title="Intrinsic factor">Intrinsic factor</a></li> <li><a href="/wiki/Orosomucoid" title="Orosomucoid">Orosomucoid</a></li> <li><a href="/wiki/Peptidoglycan" title="Peptidoglycan">Peptidoglycan</a></li> <li><a href="/wiki/Phytohaemagglutinin" title="Phytohaemagglutinin">Phytohaemagglutinin</a></li> <li><a href="/wiki/Ovomucin" title="Ovomucin">Ovomucin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Proteoglycan" title="Proteoglycan">Proteoglycans</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a>/<a href="/wiki/Dermatan_sulfate" title="Dermatan sulfate">DS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Decorin" title="Decorin">Decorin</a></li> <li><a href="/wiki/Biglycan" title="Biglycan">Biglycan</a></li> <li><a href="/wiki/Versican" title="Versican">Versican</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Heparan_sulfate" title="Heparan sulfate">HS</a>/<a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Testican" title="Testican">Testican</a></li> <li><a href="/wiki/Perlecan" title="Perlecan">Perlecan</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chondroitin_sulfate_proteoglycan" title="Chondroitin sulfate proteoglycan">Chondroitin sulfate proteoglycans</a>: <a href="/wiki/Aggrecan" title="Aggrecan">Aggrecan</a></li> <li><a href="/wiki/Neurocan" title="Neurocan">Neurocan</a></li> <li><a href="/wiki/Brevican" title="Brevican">Brevican</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/CSPG4" title="CSPG4">CSPG4</a></li> <li><a href="/wiki/CSPG5" title="CSPG5">CSPG5</a></li> <li><a href="/wiki/Platelet_factor_4" title="Platelet factor 4">Platelet factor 4</a></li> <li><a href="/wiki/SMC3_(gene)" class="mw-redirect" title="SMC3 (gene)">Structural maintenance of chromosomes 3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Keratan_sulfate" title="Keratan sulfate">KS</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fibromodulin" title="Fibromodulin">Fibromodulin</a></li> <li><a href="/wiki/Lumican" title="Lumican">Lumican</a></li> <li><a href="/wiki/Keratocan" title="Keratocan">Keratocan</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Heparan_sulfate" title="Heparan sulfate">HS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Syndecan_1" title="Syndecan 1">Syndecan 1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activin_and_inhibin" title="Activin and inhibin">Activin and inhibin</a></li> <li><a href="/wiki/A_disintegrin_and_metalloproteinase" class="mw-redirect" title="A disintegrin and metalloproteinase">ADAM</a></li> <li><a href="/wiki/Alpha_1-antichymotrypsin" title="Alpha 1-antichymotrypsin">Alpha 1-antichymotrypsin</a></li> <li><a href="/wiki/Apolipoprotein_H" title="Apolipoprotein H">Apolipoprotein H</a></li> <li><a href="/wiki/CD70" title="CD70">CD70</a></li> <li><a href="/wiki/Asialoglycoprotein" title="Asialoglycoprotein">Asialoglycoprotein</a></li> <li><a href="/wiki/Avidin" title="Avidin">Avidin</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">B-cell activating factor</a></li> <li><a href="/wiki/4-1BB_ligand" class="mw-redirect" title="4-1BB ligand">4-1BB ligand</a></li> <li><a href="/wiki/Cholesterylester_transfer_protein" class="mw-redirect" title="Cholesterylester transfer protein">Cholesterylester transfer protein</a></li> <li><a href="/wiki/Clusterin" title="Clusterin">Clusterin</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factor</a></li> <li><a href="/wiki/Hemopexin" title="Hemopexin">Hemopexin</a></li> <li><a href="/wiki/Lactoferrin" title="Lactoferrin">Lactoferrin</a></li> <li><a href="/wiki/Membrane_glycoproteins" title="Membrane glycoproteins">Membrane glycoproteins</a></li> <li><a class="mw-selflink selflink">Myelin protein zero</a></li> <li><a href="/wiki/Osteonectin" title="Osteonectin">Osteonectin</a></li> <li><a href="/wiki/Protein_C" title="Protein C">Protein C</a></li> <li><a href="/wiki/Protein_S" title="Protein S">Protein S</a></li> <li><a href="/wiki/Serum_amyloid_P_component" title="Serum amyloid P component">Serum amyloid P component</a></li> <li><a href="/wiki/Sialoglycoprotein" title="Sialoglycoprotein">Sialoglycoprotein</a> <ul><li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/Glycophorin" title="Glycophorin">Glycophorin</a></li> <li><a href="/wiki/Glycophorin_C" title="Glycophorin C">Glycophorin C</a></li></ul></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin</a></li> <li><a href="/wiki/Thyroglobulin" title="Thyroglobulin">Thyroglobulin</a></li> <li><a href="/wiki/Thyroxine-binding_proteins" title="Thyroxine-binding proteins">Thyroxine-binding proteins</a></li> <li><a href="/wiki/Transcortin" title="Transcortin">Transcortin</a></li> <li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">Tumor necrosis factor alpha</a></li> <li><a href="/wiki/Uteroglobin" title="Uteroglobin">Uteroglobin</a></li> <li><a href="/wiki/Vitronectin" title="Vitronectin">Vitronectin</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Membrane_proteins:_cell_adhesion_molecules" style="padding:3px"><table class="nowraplinks hlist 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style="font-size:114%;margin:0 4em"><a href="/wiki/Membrane_protein" title="Membrane protein">Membrane proteins</a>: <a href="/wiki/Cell_adhesion_molecule" title="Cell adhesion molecule">cell adhesion molecules</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_adhesion_molecule#Calcium-independent" title="Cell adhesion molecule">Calcium-independent</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/IgSF_CAM" title="IgSF CAM">IgSF CAM</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Neural_cell_adhesion_molecule" title="Neural cell adhesion molecule">N-CAM</a> (<a class="mw-selflink selflink">Myelin protein zero</a>)</li> <li><a href="/wiki/Intercellular_adhesion_molecule" title="Intercellular adhesion molecule">ICAM</a> (<a href="/wiki/ICAM-1" title="ICAM-1">1</a>, <a href="/wiki/ICAM5" title="ICAM5">5</a>)</li> <li><a href="/wiki/VCAM-1" title="VCAM-1">VCAM-1</a></li> <li><a href="/wiki/CD31" title="CD31">PE-CAM</a></li> <li><a href="/wiki/L1_family" title="L1 family">L1 family</a> <ul><li><a href="/wiki/L1_(protein)" title="L1 (protein)">L1-CAM</a></li> <li><a href="/wiki/NRCAM" title="NRCAM">NRCAM</a></li> <li><a href="/wiki/NFASC" title="NFASC">NFASC</a></li> <li><a href="/wiki/CHL1" title="CHL1">CHL1</a></li></ul></li> <li><a href="/wiki/Nectin" title="Nectin">Nectin</a> <ul><li><a href="/wiki/PVRL1" class="mw-redirect" title="PVRL1">PVRL1</a></li> <li><a href="/wiki/PVRL2" class="mw-redirect" title="PVRL2">PVRL2</a></li> <li><a href="/wiki/PVRL3" class="mw-redirect" title="PVRL3">PVRL3</a></li> <li><a href="/wiki/CADM1" class="mw-redirect" title="CADM1">CADM1</a></li> <li><a href="/wiki/CADM3" title="CADM3">CADM3</a></li> <li><a href="/wiki/CD155" title="CD155">CD155</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Integrin" title="Integrin">Integrins</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lymphocyte_function-associated_antigen_1" title="Lymphocyte function-associated antigen 1">LFA-1</a> (<a href="/wiki/CD11a" class="mw-redirect" title="CD11a">CD11a</a>+<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a>)</li> <li><a href="/wiki/Integrin_alphaXbeta2" class="mw-redirect" title="Integrin alphaXbeta2">Integrin alphaXbeta2</a> (<a href="/wiki/CD11c" class="mw-redirect" title="CD11c">CD11c</a>+<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a>)</li> <li><a href="/wiki/Macrophage-1_antigen" title="Macrophage-1 antigen">Macrophage-1 antigen</a> (<a href="/wiki/CD11b" class="mw-redirect" title="CD11b">CD11b</a>+<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a>)</li> <li><a href="/wiki/VLA-4" title="VLA-4">VLA-4</a> (<a href="/wiki/CD49d" class="mw-redirect" title="CD49d">CD49d</a>+<a href="/wiki/CD29" class="mw-redirect" title="CD29">CD29</a>)</li> <li><a href="/wiki/Glycoprotein_IIb/IIIa" title="Glycoprotein IIb/IIIa">Glycoprotein IIb/IIIa</a> (<a href="/wiki/ITGA2B" class="mw-redirect" title="ITGA2B">ITGA2B</a>+<a href="/wiki/ITGB3" class="mw-redirect" title="ITGB3">ITGB3</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_adhesion_molecule#Calcium-dependent" title="Cell adhesion molecule">Calcium-dependent</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cadherin" title="Cadherin">Cadherins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Classical</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CDH1_(gene)" class="mw-redirect" title="CDH1 (gene)">CDH1</a></li> <li><a href="/wiki/CDH2" class="mw-redirect" title="CDH2">CDH2</a></li> <li><a href="/wiki/CDH3_(gene)" title="CDH3 (gene)">CDH3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Desmosome" title="Desmosome">Desmosomal</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Desmoglein" title="Desmoglein">Desmoglein</a> (<a href="/wiki/Desmoglein-1" title="Desmoglein-1">DSG1</a>, <a href="/wiki/Desmoglein-2" title="Desmoglein-2">DSG2</a>, <a href="/wiki/Desmoglein-3" title="Desmoglein-3">DSG3</a>, <a href="/wiki/Desmoglein-4" title="Desmoglein-4">DSG4</a>)</li> <li><a href="/wiki/Desmocollin" title="Desmocollin">Desmocollin</a> (<a href="/wiki/DSC1" title="DSC1">DSC1</a>, <a href="/wiki/DSC2" title="DSC2">DSC2</a>, <a href="/wiki/DSC3" title="DSC3">DSC3</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Protocadherin" title="Protocadherin">Protocadherin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PCDH1" title="PCDH1">PCDH1</a></li> <li><a href="/wiki/PCDH15" title="PCDH15">PCDH15</a></li> <li><a href="/wiki/Protocadherin_19" title="Protocadherin 19">PCDH19</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Unconventional/ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/T-cadherin" title="T-cadherin">T-cadherin</a></li> <li><a href="/wiki/CDH4" title="CDH4">CDH4</a></li> <li><a href="/wiki/VE-cadherin" title="VE-cadherin">CDH5</a></li> <li><a href="/wiki/CDH6" title="CDH6">CDH6</a></li> <li><a href="/wiki/CDH8" title="CDH8">CDH8</a></li> <li><a href="/wiki/CDH11" title="CDH11">CDH11</a></li> <li><a href="/wiki/CDH12" title="CDH12">CDH12</a></li> <li><a href="/wiki/CDH15" title="CDH15">CDH15</a></li> <li><a href="/wiki/CDH16" title="CDH16">CDH16</a></li> <li><a href="/wiki/CDH17" title="CDH17">CDH17</a></li> <li><a href="/wiki/CDH9" title="CDH9">CDH9</a></li> <li><a href="/wiki/CDH10" title="CDH10">CDH10</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Selectin" title="Selectin">Selectins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/E-selectin" title="E-selectin">E-selectin</a></li> <li><a href="/wiki/L-selectin" title="L-selectin">L-selectin</a></li> <li><a href="/wiki/P-selectin" title="P-selectin">P-selectin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lymphocyte_homing_receptor" title="Lymphocyte homing receptor">Lymphocyte homing receptor</a>: <a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/L-selectin" title="L-selectin">L-selectin</a></li> <li><i><a href="/wiki/Integrin" title="Integrin">integrin</a></i> (<a href="/wiki/VLA-4" title="VLA-4">VLA-4</a>, <a href="/wiki/LFA-1" class="mw-redirect" title="LFA-1">LFA-1</a>)</li></ul> <ul><li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">Carcinoembryonic antigen</a></li> <li><a href="/wiki/CD24" title="CD24">CD24</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/CD146" title="CD146">CD146</a></li> <li><a href="/wiki/Epithelial_cell_adhesion_molecule" title="Epithelial cell adhesion molecule">EpCAM</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Protein:_cell_membrane_proteins_(other_than_Cell_surface_receptor,_enzymes,_and_cytoskeleton)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Other_cell_membrane_proteins" title="Template:Other cell membrane proteins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Other_cell_membrane_proteins" title="Template talk:Other cell membrane proteins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Other_cell_membrane_proteins" title="Special:EditPage/Template:Other cell membrane proteins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Protein:_cell_membrane_proteins_(other_than_Cell_surface_receptor,_enzymes,_and_cytoskeleton)" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Protein</a>: cell <a href="/wiki/Membrane_protein" title="Membrane protein">membrane proteins</a> (other than <a href="/wiki/Cell_surface_receptor" title="Cell surface receptor">Cell surface receptor</a>, <a href="/wiki/Enzyme" title="Enzyme">enzymes</a>, and <a href="/wiki/Cytoskeleton" title="Cytoskeleton">cytoskeleton</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Arrestin" title="Arrestin">Arrestin</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/SAG_(gene)" title="SAG (gene)">SAG</a></li> <li><a href="/wiki/Arrestin_beta_1" title="Arrestin beta 1">ARRB1</a></li> <li><a href="/wiki/Arrestin_beta_2" title="Arrestin beta 2">ARRB2</a></li> <li><a href="/wiki/ARR3" title="ARR3">ARR3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Membrane-spanning_4A" title="Membrane-spanning 4A">Membrane-spanning 4A</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD20" title="CD20">MS4A1</a></li> <li><a href="/wiki/MS4A2" title="MS4A2">MS4A2</a></li> <li><a href="/wiki/MS4A3" title="MS4A3">MS4A3</a></li> <li><a href="/w/index.php?title=MS4A4A&action=edit&redlink=1" class="new" title="MS4A4A (page does not exist)">MS4A4A</a></li> <li><a href="/w/index.php?title=MS4A4E&action=edit&redlink=1" class="new" title="MS4A4E (page does not exist)">MS4A4E</a></li> <li><a href="/w/index.php?title=MS4A5&action=edit&redlink=1" class="new" title="MS4A5 (page does not exist)">MS4A5</a></li> <li><a href="/w/index.php?title=MS4A6A&action=edit&redlink=1" class="new" title="MS4A6A (page does not exist)">MS4A6A</a></li> <li><a href="/w/index.php?title=MS4A6E&action=edit&redlink=1" class="new" title="MS4A6E (page does not exist)">MS4A6E</a></li> <li><a href="/wiki/MS4A7" title="MS4A7">MS4A7</a></li> <li><a href="/w/index.php?title=MS4A8B&action=edit&redlink=1" class="new" title="MS4A8B (page does not exist)">MS4A8B</a></li> <li><a href="/w/index.php?title=MS4A9&action=edit&redlink=1" class="new" title="MS4A9 (page does not exist)">MS4A9</a></li> <li><a href="/w/index.php?title=MS4A10&action=edit&redlink=1" class="new" title="MS4A10 (page does not exist)">MS4A10</a></li> <li><a href="/w/index.php?title=MS4A12&action=edit&redlink=1" class="new" title="MS4A12 (page does not exist)">MS4A12</a></li> <li><a href="/w/index.php?title=MS4A13&action=edit&redlink=1" class="new" title="MS4A13 (page does not exist)">MS4A13</a></li> <li><a href="/w/index.php?title=MS4A14&action=edit&redlink=1" class="new" title="MS4A14 (page does not exist)">MS4A14</a></li> <li><a href="/w/index.php?title=MS4A15&action=edit&redlink=1" class="new" title="MS4A15 (page does not exist)">MS4A15</a></li> <li><a href="/w/index.php?title=MS4A18&action=edit&redlink=1" class="new" title="MS4A18 (page does not exist)">MS4A18</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myelin" title="Myelin">Myelin</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Myelin_basic_protein" title="Myelin basic protein">Myelin basic protein</a> <ul><li><a href="/wiki/PMP2" title="PMP2">PMP2</a></li></ul></li> <li><a href="/wiki/Myelin_proteolipid_protein" title="Myelin proteolipid protein">Myelin proteolipid protein</a> <ul><li><a href="/wiki/Proteolipid_protein_1" title="Proteolipid protein 1">PLP1</a></li></ul></li> <li><a href="/wiki/Myelin_oligodendrocyte_glycoprotein" title="Myelin oligodendrocyte glycoprotein">Myelin oligodendrocyte glycoprotein</a></li> <li><a href="/wiki/Myelin-associated_glycoprotein" title="Myelin-associated glycoprotein">Myelin-associated glycoprotein</a></li> <li><a class="mw-selflink selflink">Myelin protein zero</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pulmonary_surfactant" title="Pulmonary surfactant">Pulmonary surfactant</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pulmonary_surfactant-associated_protein_B" class="mw-redirect" title="Pulmonary surfactant-associated protein B">Pulmonary surfactant-associated protein B</a></li> <li><a href="/wiki/Pulmonary_surfactant-associated_protein_C" class="mw-redirect" title="Pulmonary surfactant-associated protein C">Pulmonary surfactant-associated protein C</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tetraspanin" title="Tetraspanin">Tetraspanin</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=TSPAN1&action=edit&redlink=1" class="new" title="TSPAN1 (page does not exist)">TSPAN1</a></li> <li><a href="/wiki/TSPAN2" title="TSPAN2">TSPAN2</a></li> <li><a href="/wiki/TSPAN3" title="TSPAN3">TSPAN3</a></li> <li><a href="/wiki/TSPAN4" title="TSPAN4">TSPAN4</a></li> <li><a href="/w/index.php?title=TSPAN5&action=edit&redlink=1" class="new" title="TSPAN5 (page does not exist)">TSPAN5</a></li> <li><a href="/wiki/TSPAN6" title="TSPAN6">TSPAN6</a></li> <li><a href="/wiki/TSPAN7" title="TSPAN7">TSPAN7</a></li> <li><a href="/wiki/TSPAN8" title="TSPAN8">TSPAN8</a></li> <li><a href="/wiki/TSPAN9" class="mw-redirect" title="TSPAN9">TSPAN9</a></li> <li><a href="/wiki/TSPAN10" class="mw-redirect" title="TSPAN10">TSPAN10</a></li> <li><a href="/w/index.php?title=TSPAN11&action=edit&redlink=1" class="new" title="TSPAN11 (page does not exist)">TSPAN11</a></li> <li><a href="/wiki/TSPAN12" title="TSPAN12">TSPAN12</a></li> <li><a href="/wiki/TSPAN13" title="TSPAN13">TSPAN13</a></li> <li><a href="/wiki/TSPAN14" title="TSPAN14">TSPAN14</a></li> <li><a href="/w/index.php?title=TSPAN15&action=edit&redlink=1" class="new" title="TSPAN15 (page does not exist)">TSPAN15</a></li> <li><a href="/w/index.php?title=TSPAN16&action=edit&redlink=1" class="new" title="TSPAN16 (page does not exist)">TSPAN16</a></li> <li><a href="/w/index.php?title=TSPAN17&action=edit&redlink=1" class="new" title="TSPAN17 (page does not exist)">TSPAN17</a></li> <li><a href="/wiki/TSPAN18" class="mw-redirect" title="TSPAN18">TSPAN18</a></li> <li><a href="/w/index.php?title=TSPAN19&action=edit&redlink=1" class="new" title="TSPAN19 (page does not exist)">TSPAN19</a></li> <li><a href="/w/index.php?title=TSPAN20&action=edit&redlink=1" class="new" title="TSPAN20 (page does not exist)">TSPAN20</a></li> <li><a href="/wiki/TSPAN21" class="mw-redirect" title="TSPAN21">TSPAN21</a></li> <li><a href="/w/index.php?title=TSPAN22&action=edit&redlink=1" class="new" title="TSPAN22 (page does not exist)">TSPAN22</a></li> <li><a href="/wiki/TSPAN23" class="mw-redirect" title="TSPAN23">TSPAN23</a></li> <li><a href="/wiki/CD151" title="CD151">TSPAN24</a></li> <li><a href="/wiki/CD53" title="CD53">TSPAN25</a></li> <li><a href="/wiki/CD37" title="CD37">TSPAN26</a></li> <li><a href="/wiki/CD82_(gene)" title="CD82 (gene)">TSPAN27</a></li> <li><a href="/wiki/CD81" title="CD81">TSPAN28</a></li> <li><a href="/wiki/CD9" title="CD9">TSPAN29</a></li> <li><a href="/wiki/CD63" title="CD63">TSPAN30</a></li> <li><a href="/wiki/TSPAN31" title="TSPAN31">TSPAN31</a></li> <li><a href="/wiki/TSPAN32" title="TSPAN32">TSPAN32</a></li> <li><a href="/w/index.php?title=TSPAN33&action=edit&redlink=1" class="new" title="TSPAN33 (page does not exist)">TSPAN33</a></li> <li><a href="/w/index.php?title=TSPAN34&action=edit&redlink=1" class="new" title="TSPAN34 (page does not exist)">TSPAN34</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other/ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calnexin" title="Calnexin">Calnexin</a></li> <li><a href="/wiki/LDL-receptor-related_protein-associated_protein" title="LDL-receptor-related protein-associated protein">LDL-receptor-related protein-associated protein</a></li> <li><a href="/wiki/Merlin_(protein)" title="Merlin (protein)">Neurofibromin 2</a></li> <li><a href="/wiki/Presenilin" title="Presenilin">Presenilin</a> <ul><li><a href="/wiki/PSEN1" class="mw-redirect" title="PSEN1">PSEN1</a></li> <li><a href="/wiki/PSEN2" class="mw-redirect" title="PSEN2">PSEN2</a></li></ul></li> <li><a href="/wiki/HFE_(gene)" title="HFE (gene)">HFE</a></li> <li><a href="/wiki/Phospholipid_scramblase" title="Phospholipid scramblase">Phospholipid transfer proteins</a></li> <li><a href="/wiki/Dysferlin" title="Dysferlin">Dysferlin</a></li> <li><a href="/wiki/STRC" title="STRC">STRC</a></li> <li><a href="/wiki/OTOF" class="mw-redirect" title="OTOF">OTOF</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="padding:0;"><div><i>see also <a href="/wiki/Template:Other_cell_membrane_protein_disorders" title="Template:Other cell membrane protein disorders">other cell membrane protein disorders</a></i></div></td></tr></tbody></table></div> <div role="note" style="font-style: italic;">This article incorporates text from the public domain <a href="/wiki/Pfam" title="Pfam">Pfam</a> and <a href="/wiki/InterPro" title="InterPro">InterPro</a>: <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR019566">IPR019566</a></div>    </div><noscript><img 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